Vessel constrictor
This is the step that decides whether the illness resolves or leaves a permanent deficit. An agent tested specifically on whether it prevents that progression worked through this route.
In depth
The signaling route along which inflammation becomes lasting structural damage.
What drives it
Heart muscle inflammation increases it.
The road from inflammation to a permanently enlarged heart. Quercetin 'offers cardioprotection against progression of experimental autoimmune myocarditis by suppression of oxidative and endoplasmic reticulum stress via ENDOTHELIN-1/MAPK signaling' — tested explicitly on whether it 'protects from the progression of EAM to dilated cardiomyopathy' (PMID 22145946 — Quercetin offers cardioprotection against progression of experimental autoimmune myocarditis by suppression of oxidative and endoplasmic reticulum stress via endothelin-1/MAPK signaling). ⇒ this is the step that decides whether the illness ends OR becomes permanent. PMID 22145946
What it drives
It increases Enlarged heart.
The road from inflammation to a permanently enlarged heart. Quercetin 'offers cardioprotection against progression of experimental autoimmune myocarditis by suppression of oxidative and endoplasmic reticulum stress via ENDOTHELIN-1/MAPK signaling' — tested explicitly on whether it 'protects from the progression of EAM to dilated cardiomyopathy' (PMID 22145946 — Quercetin offers cardioprotection against progression of experimental autoimmune myocarditis by suppression of oxidative and endoplasmic reticulum stress via endothelin-1/MAPK signaling). ⇒ this is the step that decides whether the illness ends OR becomes permanent. PMID 22145946
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.