The Metabolite Veto
You want to know the family is larger than it looks. Succinate is named in the same list of signals that inhibit the messenger through their own receptors. It is included for completeness of the veto family, not as a target: nothing in this formula addresses it, and its physiological role in this specific braking is less studied than lactate or the fatty-acid receptors.
In depth
A receptor for succinate — a mitochondrial intermediate that also brakes fat release.
What drives it
TCA metabolite increases it.
Succinate is the endogenous ligand of the GPR91/SUCNR1 receptor. doi 10.1016/j.celrep.2021.109246
What it drives
It reduces The cell's go-signal.
'ligands of Gi-coupled receptors, such as succinate, short-chain fatty acids... GPR91' (doi 10.3389/fphys.2022.826314). Included for completeness of the veto family, not as a target — its specific role in this braking is less studied than lactate or the fatty-acid receptors, and nothing in this formula addresses it. doi 10.3389/fphys.2022.826314
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.