The Handbrake the Virus Releases
This is the cruellest step on the map. Left alone, this protein restrains the machinery that makes cells burst and inflame their neighbors. Both viral blades are required to cut it — which means the bursting death is not an accident of infection. The virus actively unlocks it.
In depth
The protein that normally holds back inflammatory cell death.
What drives it
The Virus’s Own Scissors reduces it.
And this is the cruellest trick in the whole MAP: the virus releases the brake on the cell's self-destruct. 'both 2A and 3C are required for cleavage of CARD8, which normally functions to inhibit activation of CASP1 and pyroptosis' (pmc10178405 · PMID 37175422 — Role of Coxsackievirus b3-Induced Immune Responses in the Transition from Myocarditis to Dilated Cardiomyopathy and Heart Failure). ⇒ CARD8 is a handbrake. Cutting it lets the inflammatory cell-death machinery run. the bursting cell death is not an accident of the infection — the virus actively unlocks it. PMID 37175422
Viral protease 3C reduces it.
And this is the cruellest trick in the whole MAP: the virus releases the brake on the cell's self-destruct. 'both 2A and 3C are required for cleavage of CARD8, which normally functions to inhibit activation of CASP1 and pyroptosis' (pmc10178405 · PMID 37175422 — Role of Coxsackievirus b3-Induced Immune Responses in the Transition from Myocarditis to Dilated Cardiomyopathy and Heart Failure). ⇒ CARD8 is a handbrake. Cutting it lets the inflammatory cell-death machinery run. the bursting cell death is not an accident of the infection — the virus actively unlocks it. PMID 37175422
What it drives
It reduces Inflammatory protease.
And this is the cruellest trick in the whole MAP: the virus releases the brake on the cell's self-destruct. 'both 2A and 3C are required for cleavage of CARD8, which normally functions to inhibit activation of CASP1 and pyroptosis' (pmc10178405 · PMID 37175422 — Role of Coxsackievirus b3-Induced Immune Responses in the Transition from Myocarditis to Dilated Cardiomyopathy and Heart Failure). ⇒ CARD8 is a handbrake. Cutting it lets the inflammatory cell-death machinery run. the bursting cell death is not an accident of the infection — the virus actively unlocks it. PMID 37175422
It reduces Inflammatory cell rupture.
And this is the cruellest trick in the whole MAP: the virus releases the brake on the cell's self-destruct. 'both 2A and 3C are required for cleavage of CARD8, which normally functions to inhibit activation of CASP1 and pyroptosis' (pmc10178405 · PMID 37175422 — Role of Coxsackievirus b3-Induced Immune Responses in the Transition from Myocarditis to Dilated Cardiomyopathy and Heart Failure). ⇒ CARD8 is a handbrake. Cutting it lets the inflammatory cell-death machinery run. the bursting cell death is not an accident of the infection — the virus actively unlocks it. PMID 37175422
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.