The Gate the Immune Cells Come Through
Blocking this gate reduced activated T cells and macrophages inside the heart muscle and eased the injury. A second, independent way to stop the invasion — not by chasing the virus, but by shutting the door.
In depth
A surface protein that admits activated T cells and macrophages to heart tissue.
What drives it
Heart muscle inflammation increases it.
The gateway that lets T cells in. Blocking it 'alleviated cardiac pathological injury and downregulated the percentage of CD45+CD3+ T cells'; 'the infiltration of activated T cells (CD69+) and macrophages (F4/80+) in the myocardium also decreased' (PMC10221111 — Inhibitor of CD147 Suppresses T Cell Activation and Recruitment in CVB3-Induced Acute Viral Myocarditis). ⇒ A second, independent way to stop the invasion — not by chasing the virus, but by shutting the door the immune cells come through. PMC10221111
What it drives
It increases Heart muscle inflammation.
The gateway that lets T cells in. Blocking it 'alleviated cardiac pathological injury and downregulated the percentage of CD45+CD3+ T cells'; 'the infiltration of activated T cells (CD69+) and macrophages (F4/80+) in the myocardium also decreased' (PMC10221111 — Inhibitor of CD147 Suppresses T Cell Activation and Recruitment in CVB3-Induced Acute Viral Myocarditis). ⇒ A second, independent way to stop the invasion — not by chasing the virus, but by shutting the door the immune cells come through. PMC10221111
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.