The Enabler
You want to understand it rather than target it. It holds the signal-erasing enzyme stable, and without it insulin fails to suppress release — which shows this pathway runs on assembly, not on quantities. A real limit is on the record: the source that established this says the precise interaction mechanism remains unknown. It is here so the map is honest about where understanding stops.
In depth
The partner protein without which insulin cannot switch fat release off at all.
What drives it
Blocks new fat cells increases it.
ABHD15 is a direct PPARgamma target gene in adipocytes; the protein it encodes is required to stabilize PDE3B. PMID 24236098
What it drives
It increases Messenger-clearing enzyme.
'stabilization of PDE3B, resulting from ABHD15 binding, is necessary for insulin-stimulated suppression of lipolysis in WAT. Upon loss of ABHD15, insulin fails to activate PDE3B-mediated cAMP degradation... Leading to unsuppressed lipolysis' (doi 10.3389/fphys.2022.826314). 'However, the precise molecular mechanism underlying the interaction between ABHD15 and PDE3B remains elusive.'. doi 10.3389/fphys.2022.826314
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.