The Chaperone
You want it low when releasing. It does not inhibit the lipase itself — it makes the inhibition by activated fat stronger, and that inhibition already depends on whether the lipase is phosphorylated. Recorded because the brake it deepens is one this formula cannot otherwise see, not because anything here addresses it.
In depth
A binding protein that deepens the block the activated fat already places on the lipase.
What drives it
Blocks new fat cells increases it.
ACBP/DBI is a PPAR-responsive adipocyte gene induced together with the lipogenic differentiation program. doi 10.1038/s41419-022-04834-5
What it drives
It reduces Fat-releasing enzyme (HSL).
'the inhibitory effect of LC-CoA on HSL activity is dependent on the phosphorylation state of HSL and further enhanced by interactions with acyl-CoA-binding protein (ACBP)' (doi 10.3389/fphys.2022.826314). It deepens an existing brake rather than applying its own. doi 10.3389/fphys.2022.826314
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.