Stress cascade trigger
Corticotropin-releasing hormone (CRH)
Also searched as Corticotropin-releasing hormone (CRH).
The hpa node models the axis; crh is its first step. Vagal stimulation suppresses crf-induced acth release, which is the mechanistic route from vagal tone to cortisol.
In depth
The opening instruction of the stress axis. It does not stay in charge: under chronic stress the drive shifts from crh-dominant to vasopressin-dominant, so the crh arrow stops applying exactly when stress becomes chronic.
What drives it
Body clock increases it.
10.1038/s41467-021-25959-9 — Drawn from the reviews of this outcome. doi 10.1038/s41467-021-25959-9
Gut-brain signal increases it.
Drawn from the reviews of this outcome.
Stress & cortisol increases it.
10.3390/brainsci13111595 — Drawn from the reviews of this outcome. doi 10.3390/brainsci13111595
What it drives
It reduces Stress resilience.
10.3389/fnins.2019.00986 — The aging outcome lists the thirteen hallmarks themselves, each mapped to its pathway and labeled with its hallmark number. (from the reviews of this outcome). doi 10.3389/fnins.2019.00986
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.