Protein synthesis hub
eIF4G translation initiation
Also searched as eIF4G translation initiation.
The virus cuts this so the cell stops making its own proteins and makes viral ones instead. Agents that work against this infection are measured partly by whether they prevent that cut.
In depth
The factor a cell needs to make its own proteins — cut by the virus.
What drives it
The Virus’s Own Scissors reduces it.
Proof of the hardest kind: put the virus's scissors in a heart with NO virus, and the heart fails. 'transgenic mice with cardiac-specific localization of protease 2A develop severe cardiac dysfunction and dilated cardiomyopathy. These findings suggest that inhibiting protease 2A activity might be an effective method to treat CVB3 infection' (pmc11125614 — Caboxamycin Inhibits Heart Inflammation in a Coxsackievirus b3-Induced Myocarditis Mouse Model). ⇒ NO infection. NO immune attack. Just the enzyme — and the heart enlarges and weakens anyway. It also cuts the cell's protein-making machinery: an agent that works here 'substantially decreased CVB3 VP1 production and cleavage of translation factor eIF4G1'.
What it drives
It increases Heart muscle cell.
Proof of the hardest kind: put the virus's scissors in a heart with NO virus, and the heart fails. 'transgenic mice with cardiac-specific localization of protease 2A develop severe cardiac dysfunction and dilated cardiomyopathy. These findings suggest that inhibiting protease 2A activity might be an effective method to treat CVB3 infection' (pmc11125614 — Caboxamycin Inhibits Heart Inflammation in a Coxsackievirus b3-Induced Myocarditis Mouse Model). ⇒ NO infection. NO immune attack. Just the enzyme — and the heart enlarges and weakens anyway. It also cuts the cell's protein-making machinery: an agent that works here 'substantially decreased CVB3 VP1 production and cleavage of translation factor eIF4G1'.
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.