Metal uptake
Intestinal metal transport
Also searched as Intestinal metal transport.
You want it low: the cheapest metal to remove is the one that never got in.
In depth
Gut metal uptake — how much of the metal in food and water crosses the intestinal wall instead of passing through.
What drives it
Gut barrier reduces it.
doi 10.1128/AEM.00695-16: Lactobacillus plantarum CCFM8610 'alleviated Cd-induced cytotoxicity in the human intestinal cell line HT-29 and protected the disruption of tight junctions in the cell monolayers. In a mouse model, probiotics with either good Cd-binding or antioxidative ability increased fecal Cd levels and decreased Cd accumulation in the tissue of Cd-exposed mice.' Converse direction: Hg 'significantly downregulated expression of intercellular junction proteins like claudin 1, occludin, ZO-1, and junctional adhesion molecule 1 (JAM1) in colon epithelial cells... thus, it promotes the uptake of other toxic metals in same conditions.'. Verbatim from the source for this edge — doi 10.1128/AEM.00695-16, PMC8289861. doi 10.1128/AEM.00695-16: · PMC8289861
What it drives
It increases Heavy metal burden.
PMID 12151624: 'The amount of Cd retained in the body was 10-fold higher in rats fed the FeD diet than in those fed the FeS diet. DMT1 mRNA was highly expressed in duodenum and was 15-fold higher in the FeD diet group' — raising intestinal uptake raised total body burden 10-fold. PMID 15105261: 'diets low in iron (Fe) result in increased absorption of Pb and Cd, suggesting common molecular mechanisms of Cd and Pb transport.'. Verbatim from the source for this edge — PMID 12151624, PMID 15105261. doi 10.1152/ajpcell.00184.2002 · PMID 12151624
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.