Lysosomal protease
Cathepsin B release↓
Also searched as Cathepsin B release.
Normally kept sealed inside a compartment of the cell, it sets off the alarm complex when it escapes. In the viral model of this disease it is named as the step that leads to bursting cell death.
In depth
The enzyme identified as the mediator of inflammatory cell death in this illness.
What drives it
Oxidative stress increases it.
Oxidant-driven lysosomal membrane permeabilisation releases cathepsin B from the lysosome into the cytosol. PMID 37741453
What it drives
It increases Inflammatory alarm.
PMID 32328491 — A different kind of dying. Ordinary programmed cell death is quiet and tidy — the cell folds itself away. This one bursts, spilling its contents and inflaming everything around it. And the trigger is named: 'in experimental CVB3-induced myocarditis, inflammasome activation and subsequent pyroptosis seem to be mediated by cathepsin B' (ScienceDirect Topics — Coxsackievirus B3 overview (citing Toldo et al. 2014; Wang, Gao & Xiong 2014; Wang et al. 2018)). ⇒ that is why this illness amplifies itself: every cell that dies this way recruits more inflammation to kill the next one. PMID 32328491
It increases Inflammatory cell rupture.
PMC5809100 — A different kind of dying. Ordinary programmed cell death is quiet and tidy — the cell folds itself away. This one bursts, spilling its contents and inflaming everything around it. And the trigger is named: 'in experimental CVB3-induced myocarditis, inflammasome activation and subsequent pyroptosis seem to be mediated by cathepsin B' (ScienceDirect Topics — Coxsackievirus B3 overview (citing Toldo et al. 2014; Wang, Gao & Xiong 2014; Wang et al. 2018)). ⇒ that is why this illness amplifies itself: every cell that dies this way recruits more inflammation to kill the next one. PMC5809100
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.