Heavy metal excretion
Metal Excretion
Also searched as Metal Excretion.
You want it high: this is the only endpoint that means the metal is gone. Everything else is redistribution.
In depth
Metal excretion — metal actually leaving the body in urine or stool, not merely moved from one tissue to another.
What drives it
Master antioxidant increases it.
Glutathione is the tag that gets metal exported. Verbatim: the transporter 'sequesters glutathione and glutathione heavy metal conjugates to the vacuole to detoxify reactive oxygen species and heavy metals (Cd, Se, Hg, As)', and 'cadmium conjugation requires only two GSH, arsenic requires three conjugated GSH' (PMC10862839). Yeast transporter — the conjugation chemistry is the citation, not a human excretion result. PMC10862839
What it drives
It reduces Heavy metal burden.
PMC7370001: 'Compared to baseline, post-edetate lead decreased by 36% (p = 0.0004)... Pre-edetate lead decreased by 60% (p = 0.003). Pre-edetate lead excretion became undetectable in nearly 40% of patients. This study suggests that edetate disodium-based infusions may decrease the total body burden of lead.' Converse direction, PMID 7590665: when biliary excretion was blocked to <2% of control, the whole-body methylmercury half-life rose to '46 to 54 days versus 18 to 22 days'. Verbatim from the source for this edge — PMC7370001. PMID 7590665 · PMC7370001
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.