Executioner protease
Caspase-3 activation
Also searched as Caspase-3 activation.
Cell death is a chain of steps, and this is the last one — the blade itself. Studies measure its activated form directly, so a treatment that lowers it is stopping the cut rather than merely quieting the signals around it.
In depth
The enzyme that carries out programmed cell death once the decision is made.
What drives it
Cell turnover increases it.
The blade that actually cuts the cell. Apoptosis is a chain, and this enzyme is its final executioner. EAM studies measure it directly — 'the TUNEL assay, and Western blots for the expression of protein caspase-3 and cleaved-CASPASE3 were used to evaluate apoptosis' (Cell Physiol Biochem 2016;38(6):2219- — Effects of 1,25-Dihydroxyvitamin D3 on Experimental Autoimmune Myocarditis in Mice). Cleaved means activated. A treatment that lowers the cleaved form is stopping the cut, not just calming the noise around it.
What it drives
It reduces Heart muscle cell.
The blade that actually cuts the cell. Apoptosis is a chain, and this enzyme is its final executioner. EAM studies measure it directly — 'the TUNEL assay, and Western blots for the expression of protein caspase-3 and cleaved-CASPASE3 were used to evaluate apoptosis' (Cell Physiol Biochem 2016;38(6):2219- — Effects of 1,25-Dihydroxyvitamin D3 on Experimental Autoimmune Myocarditis in Mice). Cleaved means activated. A treatment that lowers the cleaved form is stopping the cut, not just calming the noise around it.
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.