Erectile tissue scarring
Erectile tissue integrity
Also searched as Erectile tissue integrity.
The Point at Which Function Becomes Structure. Smooth muscle lost to fibrosis cannot be signaled back — veno-occlusive failure follows from tissue composition, not from signaling.
In depth
Scar deposition in erectile tissue, replacing compliant smooth muscle with stiff collagen. It is the structural endpoint that makes vascular erectile dysfunction progressively less reversible.
What drives it
Reduces scarring increases it.
TGF-beta drives the collagen deposition that replaces cavernosal smooth muscle. Carried by the vascular and erectile physiology reviews. doi 10.21037/tau-2025-419 · PMC11988752
Calms body-wide inflammation increases it.
Chronic inflammation promotes fibrotic remodeling. Carried by the vascular and erectile physiology reviews. doi 10.21037/tau-2025-419 · PMC11988752
Vascular tone signal increases it.
Sustained RhoA/ROCK signaling is profibrotic as well as contractile. Carried by the vascular and erectile physiology reviews. doi 10.21037/tau-2025-419 · PMC11988752
What it drives
It reduces Sexual function.
Smooth muscle lost to fibrosis cannot be signaled back - veno-occlusive failure follows from tissue composition, not signaling. Carried by the vascular and erectile physiology reviews. doi 10.21037/tau-2025-419 · PMC11988752
It reduces Vessel wall muscle.
Fibrosis is the structural replacement of the contractile tissue. Carried by the vascular and erectile physiology reviews. doi 10.21037/tau-2025-419 · PMC11988752
Blends that modulate it
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