Droplet-fusion protein
FSP27 lipase sequestration
Also searched as FSP27 lipase sequestration.
You want it low. It is the third of three proteins that clamp the same lipase by direct contact. Three separate PADLOCKS on one enzyme is the point: the cell does not trust a single brake on the step that empties its energy store, and no botanical is known to reach any of the three.
In depth
A fat-specific protein that binds the rate-limiting lipase directly to hold it shut.
What drives it
Blocks new fat cells increases it.
PPARgamma directly induces FSP27/CIDEC transcription in adipocytes. doi 10.3389/fnut.2022.917801
What it drives
It reduces Fat-releasing enzyme (ATGL).
'Other accessory proteins can further inhibit ATGL activity through their direct protein-protein interaction with ATGL, including G0/S2 switch protein 2 (g0s2), hypoxia-induced lipid droplet-associated protein (HILPDA), and fat specific protein 27 (FSP27)' (doi 10.3389/fphys.2022.826314). Three separate PADLOCKS on one enzyme. doi 10.3389/fphys.2022.826314
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.