Dopamine clearance
COMT (catecholamine/estrogen)
Also searched as COMT (catecholamine/estrogen).
One entry in this formula works mainly by blocking this enzyme. That is worth understanding precisely, because it explains a condition on that ingredient: it does not create the release signal, it stops the signal being broken down. If there is no signal — fed, still, resting — there is nothing to preserve. The ingredient is not weak; it is conditional.
In depth
The enzyme that destroys the adrenaline signal — blocking it makes an existing signal last longer.
What drives it
Universal methyl donor increases it.
SAMe is the obligate methyl donor for COMT-catalyzed O-methylation of catecholamines. PMID 21095459
Estrogen balance reduces it.
Estrogen represses COMT transcription through an estrogen-response element in the COMT promoter. doi 10.1371/journal.pone.0074065
What it drives
It reduces Alertness chemical.
10.5455/cap.20131025120419 — Nbk540977 — the enzyme that shreds the signal — and the actual mechanism behind one of this formula's entries. 'Le plus important est l'inhibition de la CATÉCHOL-o-MÉTHYLE-TRANSFÉRASE (comt) par l'EGCG' = the most important action is the inhibition of catechol-o-methyltransferase by the green-tea catechin (Médecine & Nutrition — Les récepteurs adrénergiques de l'adipocyte — FRANÇAIS). ⇒ this explains the condition already on the green tea card: that it works 'in the presence, but not the absence, of noradrenaline'. It does not create the signal. It stops the signal being destroyed. NO signal, nothing to preserve — which is why the timing rule is not optional. doi 10.5455/cap.20131025120419
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.