Barrier integrity
Blood-brain barrier integrity
Also searched as Blood-brain barrier integrity.
Blood-Brain Barrier
In depth
The tight seal of cells that decides what in the bloodstream is allowed near a neuron. When it loosens, things reach the brain that were never meant to, and inflammation follows them in.
What drives it
Cortical spreading wave reduces it.
Cortical spreading depression raised MMP-9 activity in the affected cortex and caused plasma protein leakage, blood-brain barrier opening and brain edema, all of which were prevented by MMP inhibition and absent in MMP-9 knockout mice, showing that CSD degrades barrier integrity. doi 10.1172/JCI21227 · PMID 15146242
What it drives
It reduces Brain inflammation.
This comprehensive review shows that an intact blood-brain barrier excludes plasma proteins, peripheral immune cells and neurotoxins from brain parenchyma, and that when barrier integrity is lost those components enter and trigger glial activation and neuroinflammatory injury. doi 10.1152/physrev.00050.2017 · PMID 30280653
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.