Bacterial urease
Urea hydrolysis to ammonia↓
Also searched as Urea hydrolysis to ammonia.
It is the reason the stomach’s own defense does not finish the job. Block the shield and the acid the organism is sheltering from becomes its problem again — which is why urease is the most screened target in this entire literature.
In depth
H. pylori urease — the enzyme the organism uses to split urea into ammonia and neutralize the acid immediately around it, which is how it survives a compartment that kills almost everything else.
What it drives
It increases H. pylori.
The enzyme that lets the organism hold a compartment that kills almost everything else. Verbatim, J Ethnopharmacol 2024 S0378874124006950 (Phellodendron chinense; urease enzyme kinetics + RT-qPCR of virulence genes): it ‘induced alterations in bacterial morphology and structure, downregulated the expression of various virulence genes, and inhibited urease enzyme activity.’ independent group (KoreaMed RID 2256470, Korean red ginseng): protopanaxatriol ‘remarkably suppressed H. pylori urease and H+/K+ ATPase’. For scale, doi 10.1128/aac.43.7.1788: of 77 plant-derived foodstuffs screened, green tea extract was the strongest urease inhibitor, IC50 13 ug/mL, catechins the active principle. Scope stated before anyone asks: urease inhibition is a colonization mechanism, not eradication — the same AAC paper says ‘clinical trials with such an antibacterial agent alone have mostly failed to eradicate H. pylori.’ measured negative kept on the record: Saussurea lappa costunolide inhibits growth but ‘had NO inhibitory effect of H. pylori urease activity’. doi 10.1128/aac.43.7.1788:
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.