Topical capsaicin

Interstellar grade A

Human trial evidence: Randomized human trials, or a meta-analysis of them, measuring this pathway's own endpoint — either a clinical outcome or a validated biomarker.

Appears on 1 blend page, linked below.

Depletes substance P, the pain neuropeptide, from nerve endings.

Where it appears

One blend page carries this ingredient. Open it and you will find this ingredient in the list.

• Ascendance (Analgesic & Anti-Inflammatory)

Pathways it touches