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Ingredient

Piperlongumine

Piper longum

Piperlongumine (Piper longum)
Interstellar grade B

Preclinical: Mechanistic, cell or animal evidence. No single preclinical driver opens a pathway on its own.

Appears on 1 blend page, linked below.

Long pepper's alkaloid raises reactive oxygen inside the cell until it begins consuming its own damaged parts. Mop the oxygen up, or delete the gene that starts the clearing, and the effect vanishes.

What the evidence shows

Every line below is carried on the blend page that makes the claim. Follow it to the pathway and its sources.

Piperlongumine, a long-pepper alkaloid, showed senolytic activity in cultured senescent cells by raising reactive-oxygen species and destabilizing anti-apoptotic (BCL-2 family) proteins.

Senolytic (Senescent Zombie Cell Clearance) →

Where it appears

One blend page carries this ingredient. Open it and you will find this ingredient in the list.

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