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STAT3

  1. A cell-permeable STAT3 SH2 domain mimetic inhibitor of STAT3 activation inhibits growth of human breast tumor xenografts
  2. A cell-permeable STAT3 SH2 domain mimetic inhibits STAT3 activation and induces antitumor cell effects in vitro
  3. A low-molecular-weight compound discovered through virtual database screening inhibits STAT3 function in breast cancer cells
  4. A membrane penetrating peptide aptamer inhibits STAT3 function and suppresses the growth of STAT3 addicted tumor cells
  5. A millet bran-derived peroxidase inhibits cell migration by antagonizing STAT3-mediated epithelial-mesenchymal transition in human colon cancer
  6. A natural compound derivative P-13 inhibits STAT3 signaling by covalently inhibiting Janus kinase 2
  7. A novel curcumin analog inhibits canonical and non-canonical functions of telomerase through STAT3 and NF-κB inactivation in colorectal cancer cells
  8. A novel imidazole derivate inhibits STAT3 activation via induction of SHP-1 hepatocellular carcinoma
  9. A novel non-phosphorylated potential antitumoral peptide inhibits STAT3 biological activity
  10. A novel platinum compound inhibits constitutive STAT3 signaling and induces cell cycle arrest and apoptosis of malignant cells
  11. A novel small molecular STAT3 inhibitor, LY5, inhibits cell viability, cell migration, and angiogenesis in medulloblastoma cells
  12. A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells
  13. A novel small molecule STAT3 inhibitor, LY5, inhibits cell viability, colony formation, and migration of colon and liver cancer cells
  14. A novel small molecule, LLL12, inhibits IL-6 induced STAT3 phosphorylation and nuclear translocation
  15. A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells
  16. A novel small molecule, LY5, selectively inhibits STAT3 phosphorylation and activities and exhibits potent growth suppressive activity in cancer cells.
  17. A novel synthetic Asiatic acid derivative induces apoptosis and inhibits proliferation and mobility of gastric cancer cells by suppressing STAT3 signaling …
  18. A phosphopeptide mimetic prodrug targeting the SH2 domain of STAT3 inhibits tumor growth and angiogenesis
  19. A serine protease extracted from Trichosanthes kirilowii inhibits epithelial-mesenchymal transition via antagonizing PKM2-mediated STAT3/Snail1 pathway in human …
  20. A small molecule compound targeting STAT3 DNA-binding domain inhibits cancer cell proliferation, migration, and invasion
  21. A small molecule, LLL12 inhibits constitutive STAT3 and IL‐6‐induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma …
  22. Abstract B95: A novel small molecule, LLL12 inhibits STAT3 phosphorylation and activities and exhibits potent growth suppressive activity in human hepatocellular …
  23. Abstract P6-14-13: A Flavone from Traditional East Asian Natural Extract Inhibits STAT3 and Tumor Growth in a Syngeneic Mouse Breast Cancer Model
  24. Abstract# 3693: Sorafenib inhibits STAT3-regulated expression of prosurvival Mcl-1 and Bcl-xL proteins to enhance TRAIL-mediated apoptosis in human pancreatic …
  25. Abstract# 5627: Sorafenib inhibits STAT3 signaling, cell proliferation and survival of human glioblastomas
  26. Allicin Inhibits Proliferation and Invasion in Vitro and in Vivo via SHP-1-Mediated STAT3 Signaling in Cholangiocarcinoma
  27. An ethanolic extract of ampelopsis radix exerts anti-colorectal cancer effects and potently inhibits STAT3 signaling in vitro
  28. APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1–STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival
  29. Aphanin, a triterpenoid from Amoora rohituka inhibits K-Ras mutant activity and STAT3 in pancreatic carcinoma cells
  30. Apigenin inhibits STAT3/CD36 signaling axis and reduces visceral obesity
  31. Arctigenin inhibits STAT3 and exhibits anticancer potential in human triple-negative breast cancer therapy
  32. Ascochlorin, an isoprenoid antibiotic inhibits growth and invasion of hepatocellular carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3
  33. Baohuoside I Inhibits Benzo (a) Pyrene-Induced Metastasis in A549 Lung Cancer Cells by Modulating STAT3 and EMT
  34. Bear Bile Powder Inhibits Growth of Hepatocellular Carcinoma via Suppressing STAT3 Signaling Pathway in Mice
  35. Berberine downregulates CDC6 and inhibits proliferation via targeting JAK-STAT3 signaling in keratinocytes
  36. Bigelovin inhibits STAT3 signaling by inactivating JAK2 and induces apoptosis in human cancer cells
  37. Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice …
  38. Brevilin A, a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells
  39. Butoxy Mansonone G Inhibits STAT3 and Akt Signaling Pathways in Non-Small Cell Lung Cancers: Combined Experimental and Theoretical Investigations
  40. Capillarisin inhibits constitutive and inducible STAT3 activation through induction of SHP-1 and SHP-2 tyrosine phosphatases
  41. Capsazepine inhibits JAK/STAT3 signaling, tumor growth, and cell survival in prostate cancer
  42. Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells
  43. Carnosol, a natural polyphenol, inhibits migration, metastasis and tumor growth of breast cancer via a ROS-dependent proteasome degradation of STAT3
  44. CD45 phosphatase inhibits STAT3 transcription factor activity in myeloid cells and promotes tumor-associated macrophage differentiation
  45. CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and STAT3 phosphorylation in multi-drug resistant ovarian cancer cells
  46. Celastrol inhibits proliferation and induces chemosensitization through down‐regulation of NF‐κB and STAT3 regulated gene products in multiple myeloma cells
  47. Celecoxib inhibits interleukin-6/Interleukin-6 receptor–induced JAK2/STAT3 phosphorylation in human hepatocellular carcinoma cells
  48. Celecoxib inhibits STAT3 phosphorylation and suppresses cell migration and colony forming ability in rhabdomyosarcoma cells
  49. Chalcone inhibits the activation of NF-κB and STAT3 in endothelial cells via endogenous electrophile
  50. Chikusetsusaponin IVa butyl ester (CS-IVa-Be), a novel IL6R antagonist, inhibits IL6/STAT3 signaling pathway and induces cancer cell apoptosis
  51. Chrysin induces cell growth arrest, apoptosis, and ER stress and inhibits the activation of STAT3 through the generation of ROS in bladder cancer cells
  52. Chrysin inhibits sphere formation in SMMC-7721 cells via modulation of SHP-1/STAT3 signaling pathway
  53. Constitutive activation of a slowly migrating isoform of STAT3 in mycosis fungoides: tyrphostin AG490 inhibits STAT3 activation and growth of mycosis fungoides tumor …
  54. Constitutive STAT3-activation in Sezary syndrome: tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic …
  55. Cosmomycin C inhibits signal transducer and activator of transcription 3 (STAT3) pathways in MDA-MB-468 breast cancer cell
  56. Costunolide inhibits osteosarcoma growth and metastasis via suppressing STAT3 signal pathway
  57. Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast cancer cells
  58. Cryptotanshinone inhibits esophageal squamous-cell carcinoma in vitro and in vivo through the suppression of STAT3 activation
  59. Cryptotanshinone inhibits human glioma cell proliferation in vitro and in vivo through SHP-2-dependent inhibition of STAT3 activation
  60. Cryptotanshinone Inhibits STAT3 Signaling to Alleviate Cardiac Fibrosis in Type 1‐like Diabetic Rats
  61. Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562
  62. Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2–STAT3 signaling pathway
  63. Cucurbitacin I inhibits STAT3 and induces apoptosis in Sezary cells
  64. Cucurbitacin I inhibits STAT3, but enhances STAT1 signaling in human cancer cells in vitro through disrupting actin filaments
  65. Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells
  66. Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast and pancreatic carcinomas
  67. Curcumin inhibits constitutive STAT3 phosphorylation in human pancreatic cancer cell lines and downregulation of survivin/BIRC5 gene expression
  68. Curcumin inhibits cystogenesis in autosomal dominant polycystic kidney disease cells via altering JAK2/STAT3 activity
  69. Curcumin inhibits STAT3 signaling in the colon of dextran sulfate sodium-treated mice
  70. CYTL1 inhibits tumor metastasis with decreasing STAT3 phosphorylation
  71. Debio 0617B inhibits growth of STAT3-driven solid tumors through combined inhibition of JAK, SRC, and class III/V receptor tyrosine kinases
  72. Differentiation-inducing factor-1 (DIF-1) inhibits STAT3 activity involved in gastric cancer cell proliferation via MEK-ERK-dependent pathway
  73. Dihydroartemisinin inhibits endothelial cell tube formation by suppression of the STAT3 signaling pathway
  74. Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma …
  75. Disruption of STAT3-DNMT1 interaction by SH-I-14 induces re-expression of tumor suppressor genes and inhibits growth of triple-negative breast tumor
  76. Docosahexaenoic acid (DHA) promotes immunogenic apoptosis in human multiple myeloma cells, induces autophagy and inhibits STAT3 in both tumor and …
  77. Docosahexaenoic Acid Inhibits Helicobacter pylori-induced STAT3 Phosphorylation through Activation of PPARγ.
  78. Docosahexaenoic acid inhibits Helicobacter pylori‐induced STAT3 phosphorylation through activation of PPARγ
  79. Dominant negative STAT3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction
  80. Down-regulation of STAT3 expression by vector-based small interfering RNA inhibits pancreatic cancer growth
  81. EF24 Suppresses Cholangiocellular Carcinoma Progression, Inhibits STAT3 Phosphorylation, and Induces Apoptosis via ROS-Mediated Oxidative Stress
  82. Endoplasmic reticulum stress inhibits STAT3-dependent suppression of hepatic gluconeogenesis via dephosphorylation and deacetylation
  83. Epigenomic characterization of a p53-regulated 3p22. 2 tumor suppressor that inhibits STAT3 phosphorylation via protein docking and is frequently …
  84. Eriocalyxin B inhibits STAT3 signaling by covalently targeting STAT3 and blocking phosphorylation and activation of STAT3
  85. Esculetin Inhibits Proliferation, Invasion, and Migration of Laryngeal Cancer In Vitro and In Vivo by Inhibiting Janus Kinas (JAK)-Signal Transducer and …
  86. Ethanol rapidly inhibits IL‐6‐activated STAT3 and C/EBP mRNA expression in freshly isolated rat hepatocytes
  87. Eupatilin inhibits gastric cancer cell growth by blocking STAT3-mediated VEGF expression
  88. Evodiamine inhibits STAT3 signaling by inducing phosphatase shatterproof 1 in hepatocellular carcinoma cells
  89. FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1
  90. FTY720 inhibits proliferation and epithelial-mesenchymal transition in cholangiocarcinoma by inactivating STAT3 signaling
  91. Functional graphene oxide as a plasmid-based STAT3 siRNA carrier inhibits mouse malignant melanoma growth in vivo
  92. Gambogic acid inhibits STAT3 phosphorylation through activation of protein tyrosine phosphatase SHP-1: potential role in proliferation and apoptosis
  93. Genistein inhibits angiogenesis developed during rheumatoid arthritis through the IL-6/JAK2/STAT3/VEGF signalling pathway
  94. Geranylnaringenin (CG902) inhibits constitutive and inducible STAT3 activation through the activation of SHP-2 tyrosine phosphatase
  95. Ginsenoside 20 (S)‑Rg3 inhibits the Warburg effect through STAT3 pathways in ovarian cancer cells
  96. GRIM-19 inhibits the STAT3 signaling pathway and sensitizes gastric cancer cells to radiation
  97. Hepatocyte IKKβ/NF-κB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation
  98. Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells
  99. Honokiol eliminates glioma/glioblastoma stem cell-like cells via JAK-STAT3 signaling and inhibits tumor progression by targeting epidermal growth factor …
  100. Honokiol inhibits constitutive and inducible STAT3 signaling via PU. 1-induced SHP1 expression in acute myeloid leukemia cells
  101. Honokiol inhibits lung cancer brain metastasis through inhibition of STAT3 signaling pathway
  102. I157172, a novel inhibitor of cystathionine γ-lyase, inhibits growth and migration of breast cancer cells via SIRT1-mediated deacetylation of STAT3
  103. Icaritin inhibits JAK/STAT3 signaling and growth of renal cell carcinoma
  104. IFN-λ inhibits miR-122 transcription through a STAT3-HNF4α inflammatory feedback loop in an IFN-α resistant HCV cell culture system
  105. IFNγ-dependent SOCS3 expression inhibits IL-6-induced STAT3 phosphorylation and differentially affects IL-6 mediated transcriptional responses in endothelial cells
  106. IL-32γ inhibits cancer cell growth through inactivation of NF-κB and STAT3 signals
  107. IL-32θ inhibits stemness and epithelial-mesenchymal transition of cancer stem cells via the STAT3 pathway in colon cancer
  108. IL-6, a risk factor for hepatocellular carcinoma: FLLL32 inhibits IL-6-induced STAT3 phosphorylation in human hepatocellular cancer cells
  109. Ilamycin C induces apoptosis and inhibits migration and invasion in triple-negative breast cancer by suppressing IL-6/STAT3 pathway
  110. Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity
  111. Interleukin 37 expression inhibits STAT3 to suppress the proliferation and invasion of human cervical cancer cells
  112. Isoharringtonine inhibits breast cancer stem-like properties and STAT3 signaling
  113. Isoliquiritigenin inhibits the proliferation of human renal carcinoma Caki cells through the ROS-mediated regulation of the Jak2/STAT3 pathway
  114. Janus kinase 2 inhibitor AG490 inhibits the STAT3 signaling pathway by suppressing protein translation of gp130
  115. Kaempferia parviflora Extract Inhibits STAT3 Activation and Interleukin-6 Production in HeLa Cervical Cancer Cells
  116. Knockdown of STAT3 expression by RNA interference inhibits the induction of breast tumors in immunocompetent mice
  117. Let-7a Inhibits T-Cell Proliferation and IFN-γ Secretion by Down-Regulating STAT3 Expression in Patients with Psoriasis
  118. LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model
  119. LLL12 inhibits endogenous and exogenous interleukin-6-induced STAT3 phosphorylation in human pancreatic cancer cells
  120. Long non-coding RNA TPTEP1 inhibits hepatocellular carcinoma progression by suppressing STAT3 phosphorylation
  121. LRIG1 inhibits STAT3-dependent inflammation to maintain corneal homeostasis
  122. LTP-1, a novel antimitotic agent and STAT3 inhibitor, inhibits human pancreatic carcinomas in vitro and in vivo
  123. Lumbar puncture-administered resveratrol inhibits STAT3 activation, enhancing autophagy and apoptosis in orthotopic rat glioblastomas
  124. Lycorine inhibits the growth and metastasis of breast cancer through the blockage of STAT3 signaling pathway
  125. LYR71, a derivative of trimeric resveratrol, inhibits tumorigenesis by blocking STAT3-mediated matrix metalloproteinase 9 expression
  126. Manumycin inhibits STAT3, telomerase activity, and growth of glioma cells by elevating intracellular reactive oxygen species generation
  127. Metastasis suppressor Nm23-H1 inhibits STAT3 signaling via a negative feedback mechanism
  128. Methyllucidone inhibits STAT3 activity by regulating the expression of the protein tyrosine phosphatase MEG2 in DU145 prostate carcinoma cells
  129. Micheliolide inhibits gastric cancer growth in vitro and in vivo via blockade of the IL-6/STAT3 pathway
  130. MicroRNA in vivo precipitation identifies miR-151-3p as a computational unpredictable miRNA to target STAT3 and inhibits innate IL-6 production
  131. miR-1181 inhibits invasion and proliferation via STAT3 in pancreatic cancer
  132. miR-124 inhibits STAT3 signaling to enhance T cell-mediated immune clearance of
  133. MiR-124 inhibits STAT3 signaling to enhance T cell–mediated immune clearance of glioma
  134. Morin inhibits STAT3 tyrosine 705 phosphorylation in tumor cells through activation of protein tyrosine phosphatase SHP1
  135. Natural product pectolinarigenin inhibits osteosarcoma growth and metastasis via SHP-1-mediated STAT3 signaling inhibition
  136. Natural small molecule bigelovin suppresses orthotopic colorectal tumor growth and inhibits colorectal cancer metastasis via IL6/STAT3 pathway
  137. Niclosamide Inhibits Cell Growth and Enhances Drug Sensitivity of Hepatocellular Carcinoma Cells via STAT3 Signaling Pathway
  138. Nimbolide-induced oxidative stress abrogates STAT3 signaling cascade and inhibits tumor growth in transgenic adenocarcinoma of mouse prostate model
  139. Nobiletin inhibits angiogenesis by regulating Src/FAK/STAT3-mediated signaling through PXN in ER+ breast cancer cells
  140. Novel Carbazole Inhibits Phospho-STAT3 through Induction of Protein–Tyrosine Phosphatase PTPN6
  141. Novel small molecule, XZH‐5, inhibits constitutive and interleukin‐6‐induced STAT3 phosphorylation in human rhabdomyosarcoma cells
  142. Nuclear protein IκB-ζ inhibits the activity of STAT3
  143. Obatoclax analog SC-2001 inhibits STAT3 phosphorylation through enhancing SHP-1 expression and induces apoptosis in human breast cancer cells
  144. Obatoclax analogue SC-2001 inhibits STAT3 phosphorylation by enhancing protein tyrosine phosphatase SHP-1 expression and induces apoptosis in human breast …
  145. Oleanolic acid inhibits macrophage differentiation into the M2 phenotype and glioblastoma cell proliferation by suppressing the activation of STAT3
  146. Osthole inhibits triple negative breast cancer cells by suppressing STAT3
  147. Overexpressed HO-1 is associated with reduced STAT3 activation in preeclampsia placenta and inhibits STAT3 phosphorylation in placental JEG-3 cells …
  148. p14 ARF inhibits the growth of lung adenocarcinoma cells harbouring an EGFR L858R mutation by activating a STAT3-dependent pro-apoptotic signalling …
  149. Paeoniflorin inhibits human glioma cells via STAT3 degradation by the ubiquitin–proteasome pathway
  150. Parthenolide inhibits STAT3 signaling and attenuates angiotensin II-induced left ventricular hypertrophy via modulation of fibroblast activity
  151. Parthenolide inhibits STAT3 signaling by covalently targeting Janus kinases
  152. PDLIM2 inhibits T helper 17 cell development and granulomatous inflammation through degradation of STAT3
  153. Penta-1, 2, 3, 4, 6-O-galloyl-β-d-glucose induces p53 and inhibits STAT3 in prostate cancer cells in vitro and suppresses prostate xenograft tumor growth in vivo
  154. Pentagalloylglucose inhibits the replication of rabies virus via mediating the miR-455/SOCS3/STAT3/IL-6 pathway
  155. Pentoxifylline inhibits melanoma tumor growth and angiogenesis by targeting STAT3 signaling pathway
  156. Periplocin of cortex periplocae inhibits STAT3 signaling and induces apoptosis in human hepatocellular carcinoma cell line SMMC-7721
  157. Phenethyl isothiocyanate inhibits STAT3 activation in prostate cancer cells
  158. Piperine inhibits IL-1β-induced IL-6 expression by suppressing p38 MAPK and STAT3 activation in gastric cancer cells
  159. Piperlongumine derivative, CG-06, inhibits STAT3 activity by direct binding to STAT3 and regulating the reactive oxygen species in DU145 prostate carcinoma cells
  160. Platelet factor 4 inhibits IL-17/STAT3 pathway via upregulation of SOCS3 expression in melanoma
  161. Plumbagin inhibits prostate cancer development in TRAMP mice via targeting PKCε, STAT3 and neuroendocrine markers
  162. Plumbagin inhibits prostate carcinogenesis in intact and castrated PTEN knockout mice via targeting PKCε, STAT3, and epithelial-to-mesenchymal transition markers
  163. Plumericin inhibits proliferation of vascular smooth muscle cells by blocking STAT3 signaling via S-glutathionylation
  164. Ponatinib inhibits STAT3 activity and reduces colorectal cancer growth
  165. Prolonged insulin treatment inhibits GH signaling via STAT3 and STAT1
  166. Proscillaridin A induces apoptosis, inhibits STAT3 activation and augments doxorubicin toxicity in prostate cancer cells
  167. Proscillaridin A promotes oxidative stress and ER stress, inhibits STAT3 activation, and induces apoptosis in A549 lung adenocarcinoma cells
  168. Protopanaxadiol inhibits epithelial–mesenchymal transition of hepatocellular carcinoma by targeting STAT3 pathway
  169. PTPMeg2 inhibits STAT3 transcriptional activity in NIH3 T3/STAT3 CA cell model
  170. Puupehenol natural product inhibits STAT3 signaling and induces antitumor cell effects in vitro against human glioblastoma cells
  171. Pyrrolidine dithiocarbamate inhibits interleukin-6 signaling through impaired STAT3 activation and association with transcriptional coactivators in hepatocytes
  172. Pyrvinium pamoate inhibits proliferation of myeloma/erythroleukemia cells by suppressing mitochondrial respiratory complex I and STAT3
  173. Quercetin abrogates IL-6/STAT3 signaling and inhibits glioblastoma cell line growth and migration
  174. Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling
  175. Resveratrol inhibits hypoxia-induced glioma cell migration and invasion by the p-STAT3/miR-34a axis
  176. Resveratrol inhibits Src and STAT3 signaling and induces the apoptosis of malignant cells containing activated STAT3 protein
  177. Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: Role in apoptosis induction and radiosensitization in head and neck tumor cells
  178. RFX-1-dependent activation of SHP-1 inhibits STAT3 signaling in hepatocellular carcinoma cells
  179. RIP4 inhibits STAT3 signaling to sustain lung adenocarcinoma differentiation
  180. RNA interference targeting STAT3 inhibits growth and induces apoptosis of human prostate cancer cells
  181. RNAi-mediated silencing of Anxa2 inhibits breast cancer cell proliferation by downregulating cyclin D1 in STAT3-dependent pathway
  182. S3I-201, a novel STAT3 inhibitor, inhibits growth of human soft tissue sarcoma cell lines
  183. Santamarine Inhibits NF-кB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress.
  184. Saw palmetto extract inhibits metastasis and antiangiogenesis through STAT3 signal pathway in glioma cell
  185. Scavenging reactive oxygen species selectively inhibits M2 macrophage polarization and their pro-tumorigenic function in part, via STAT3 suppression
  186. Silibinin inhibits constitutive activation of STAT3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells
  187. SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma
  188. Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3
  189. Sorafenib inhibits STAT3 activation to enhance TRAIL-mediated apoptosis in human pancreatic cancer cells
  190. SR16388 inhibits STAT3 activation and angiogenesis in lung cancer model
  191. STAT1 inhibits STAT3 activation in esophageal squamous cell carcinoma
  192. STAT3 oligonucleotide inhibits tumor angiogenesis in preclinical models of squamous cell carcinoma
  193. STAT3 silencing with lentivirus inhibits growth and induces apoptosis and differentiation of U251 cells
  194. STAT3/STAT5 blockade by WP1066 inhibits ovarian cancer cell proliferation and induces cell death
  195. Stattic inhibits RANKL-mediated osteoclastogenesis by suppressing activation of STAT3 and NF-κB pathways
  196. Sugiol inhibits STAT3 activity via regulation of transketolase and ROS-mediated ERK activation in DU145 prostate carcinoma cells
  197. Sulphoraphane inhibits STAT3 and its related genes in Du 145 cancer cells
  198. Systemic administration of a cyclic signal transducer and activator of transcription 3 (STAT3) decoy oligonucleotide inhibits tumor growth without inducing …
  199. Tanshinone I inhibits tumor angiogenesis by reducing STAT3 phosphorylation at Tyr705 and hypoxia-induced HIF-1α accumulation in both endothelial and …
  200. Tanshinone IIA inhibits cell proliferation and tumor growth by downregulating STAT3 in human gastric cancer
  201. Tanshinone IIA inhibits epithelial-mesenchymal transition in bladder cancer cells via modulation of STAT3-CCL2 signaling
  202. Targeted blockade of JAK/STAT3 signaling inhibits ovarian carcinoma growth
  203. Targeted Disruption of STAT3 Signaling Inhibits Tumor Growth and Brain Metastases by Caveolin-1 Upregulation
  204. Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice
  205. Targeting STAT3 inhibits growth and enhances radiosensitivity in head and neck squamous cell carcinoma
  206. The Antioxidant Alpha-Lipoic Acid Inhibits Proliferation and Invasion of Human Gastric Cancer Cells via Suppression of STAT3-Mediated MUC4 Gene Expression
  207. The fruits of Gleditsia sinensis Lam. inhibits adipogenesis through modulation of mitotic clonal expansion and STAT3 activation in 3T3-L1 cells
  208. The histone deacetylase inhibitor valproic acid inhibits NKG2D expression in natural killer cells through suppression of STAT3 and HDAC3
  209. The Interaction of Specific Peptide Aptamers With the DNA Binding Domain and the Dimerization Domain of the Transcription Factor STAT3 Inhibits Transactivation and …
  210. The intracellular delivery of a recombinant peptide derived from the acidic domain of PIAS3 inhibits STAT3 transactivation and induces tumor cell death
  211. The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway
  212. The JAK2/STAT3 inhibitor pacritinib effectively inhibits patient-derived GBM brain tumor initiating cells in vitro and when used in combination with …
  213. The knock-down of Caveolin-1 inhibits STAT3 signaling in human metastatic lung cancer in vitro
  214. The novel triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid inhibits metastatic murine breast tumor growth through inactivation of STAT3 …
  215. THE PHARMACOLOGICAL IGF1R-IRS1/2 INHIBITOR OSI-906 REDUCES ERYTHROID PROGENITORS AND INHIBITS STAT3 IN JAK2V617F KNOCKIN …
  216. The rabies virus interferon antagonist P protein interacts with activated STAT3 and inhibits Gp130 receptor signaling
  217. The rGel/BLyS fusion toxin inhibits STAT3 signaling via down-regulation of interleukin-6 receptor in diffuse large B-cell lymphoma
  218. The S52F FOXF1 mutation inhibits STAT3 signaling and causes alveolar capillary dysplasia
  219. The small molecule, LLL12, inhibits STAT3 phosphorylation and induces apoptosis in medulloblastoma and glioblastoma cells
  220. The synthetic triterpenoid (CDDO-Im) inhibits STAT3, as well as IL-17, and improves DSS-induced colitis in mice
  221. The tumor suppressor miR-124 inhibits cell proliferation by targeting STAT3 and functions as a prognostic marker for postoperative NSCLC patients
  222. Therapeutic ablation of gain-of-function mutant p53 in colorectal cancer inhibits STAT3-mediated tumor growth and invasion
  223. Therapeutic targeting of STAT3 (signal transducers and activators of transcription 3) pathway inhibits experimental autoimmune uveitis
  224. Thymoquinone inhibits proliferation in gastric cancer via the STAT3 pathway in vivo and in vitro
  225. TIS21/BTG2/PC3 inhibits interleukin-6 expression via downregulation of STAT3 pathway
  226. Tocilizumab inhibits neuronal cell apoptosis and activates STAT3 in cerebral infarction rat model
  227. Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)→ signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition …
  228. Ultrasound targeted microbubble destruction-mediated delivery of a transcription factor decoy inhibits STAT3 signaling and tumor growth
  229. Ursolic acid derivative FZU-03,010 inhibits STAT3 and induces cell cycle arrest and apoptosis in renal and breast cancer cells
  230. Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells
  231. Ursolic acid inhibits the growth of colon cancer-initiating cells by targeting STAT3
  232. Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumours
  233. Withaferin A inhibits JAK/STAT3 signaling and induces apoptosis of human renal carcinoma Caki cells
  234. Withaferin A inhibits STAT3 and induces tumor cell death in neuroblastoma and multiple myeloma
  235. Withaferin-A inhibits colon cancer cell growth by blocking STAT3 transcriptional activity
  236. WP1130, a small molecular weight compound, inhibits JAK2-STAT3 signaling through a unique degradation mechansim
  237. Xanthatin inhibits STAT3 and NF‐κB signalling by covalently binding to JAK and IKK kinases
  238. Xanthohumol inhibits STAT3 activation pathway leading to growth suppression and apoptosis induction in human cholangiocarcinoma cells
  239. XZH-5 inhibits STAT3 phosphorylation and causes apoptosis in human hepatocellular carcinoma cells
  240. XZH-5 inhibits STAT3 phosphorylation and enhances the cytotoxicity of chemotherapeutic drugs in human breast and pancreatic cancer cells
  241. YL064 directly inhibits STAT3 activity to induce apoptosis of multiple myeloma cells
  242. YY1 inhibits the migration and invasion of pancreatic ductal adenocarcinoma by downregulating the FER/STAT3/MMP2 signaling pathway
  243. Zerumbone inhibits growth of hormone refractory prostate cancer cells by inhibiting JAK2/STAT3 pathway and increases paclitaxel sensitivity
  244. β‐caryophyllene oxide inhibits constitutive and inducible STAT3 signaling pathway through induction of the SHP‐1 protein tyrosine phosphatase
  245. (-)-Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 via STAT3 in gastric cancer
  246. (-)-Oleocanthal exerts anti-melanoma activities and inhibits STAT3 signaling pathway
  247. (−)-Oleocanthal inhibits growth and metastasis by blocking activation of STAT3 in human hepatocellular carcinoma
  248. 15-Keto prostaglandin E2 inhibits STAT3 signaling in H-Ras transformed mammary epithelial cells
  249. 15-Keto prostaglandin E2 suppresses STAT3 signaling and inhibits breast cancer cell growth and progression
  250. 19-nor-1α-25-dihydroxyvitamin D2 induces gastric cancer cell apoptosis and cell cycle arrest and inhibits STAT3 mediated inflammation
  251. 2-Ethoxystypandrone, a novel small-molecule STAT3 signaling inhibitor from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of HCC cells …
  252. 2-Pyridyl Cyclohexanone Inhibits Activated STAT3 and Promotes Apoptosis of Human Esophageal Squamous Cell Carcinoma Cells
  253. 2′-Hydroxyflavanone inhibits prostate tumor growth through inactivation of AKT/STAT3 signaling and induction of cell apoptosis
  254. 3-Deoxy-2β, 16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the …
  255. 6-Bromoindirubin-3′-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells
  256. 782 SANGUINARINE INHIBITS STAT3 ACTIVATION AND TUMOR GROWTH IN PROSTATE CANCER CELLS
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