SUPER TONIC HAIR
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SUPER TONIC HAIR(Hair & Scalp Health)

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$275.00

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Introducing

INTERSTELLAR BLEND™

SUPER TONIC HAIR

200:1 concentration (100 Grams)

Pairs perfectly with
APIGENIN

PINE POLLEN

SPICE

PEEL

INHIBITS GRAYING

PROMOTES HAIR GROWTH

Directions: Start 1-2 tsp a day for 2 weeks then maintain with 1/4-1/2 tsp daily.

Oxidative Stress in Ageing of Hair

Experimental evidence supports the hypothesis that oxidative stress plays a major role in the ageing process. Reactive oxygen species are generated by a multitude of endogenous and environmental challenges. Reactive oxygen species or free radicals are highly reactive molecules that can directly damage cellular structural membranes, lipids, proteins, and DNA. The body possesses endogenous defence mechanisms, such as antioxidative enzymes and non-enzymatic antioxidative molecules, protecting it from free radicals by reducing and neutralizing them. With age, the production of free radicals increases, while the endogenous defence mechanisms decrease. This imbalance leads to the progressive damage of cellular structures, presumably resulting in the ageing phenotype. Ageing of hair manifests as decrease of melanocyte function or graying, and decrease in hair production or alopecia. There is circumstantial evidence that oxidative stress may be a pivotal mechanism contributing to hair graying and hair loss. New insights into the role and prevention of oxidative stresscould open new strategies for intervention and reversal of the hair graying process and age-dependent alopecia.

Age-Induced Hair Graying and Oxidative Stress

Experimental evidence supports the hypothesis that oxidative stress plays a major role in the ageing process. Reactive oxygen species are generated by a multitude of endogenous and environmental challenges. Reactive oxygen species or free radicals are highly reactive molecules that can directly damage cellular structural membranes, lipids, proteins, and DNA. The body possesses endogenous defence mechanisms, such as antioxidative enzymes and non-enzymatic antioxidative molecules, protecting it from free radicals by reducing and neutralizing them. With age, the production of free radicals increases, while the endogenous defence mechanisms decrease. This imbalance leads to the progressive damage of cellular structures, presumably resulting in the ageing phenotype. Ageing of hair manifests as decrease of melanocyte function or graying, and decrease in hair production or alopecia. There is circumstantial evidence that oxidative stress may be a pivotal mechanism contributing to hair graying and hair loss. New insights into the role and prevention of oxidative stress could open new strategies for intervention and reversal of the hair graying process and age-dependent alopecia.

Age-Induced Hair Graying and Oxidative Stress

Age-inducedhairgraying (canities), or the age-induced loss of melanin synthesis and deposition within thehair shafts, is a noticeable and undesired sign of the aging process. Numerous mechanisms contribute to age-inducedhair graying, affecting both follicular and stem cell melanocytes and acting at different follicular locations. Many of these processes are induced, directly or indirectly, by oxidative insults and damage. Melanin-producing bulbar melanocytes express high levels of BCL-2 to survive reactive oxygen species (ROS) attacks, which are induced by the melanogenic process itself and by ultraviolet A (UVA) irradiation. With aging, the expression of BCL-2, and possibly of TRP-2, is reduced, and the endogenous, enzymatic antioxidant defense system declines, resulting in greateroxidative stress. In particular, catalase expression and activity are markedly reduced with aging, leading to millimolar accumulation of hydrogen peroxide within the hairfollicle and contributing to bulbar melanocyte failure and death. Additionally, exposure of melanocyte stem cells to cumulative oxidative damage, combined with reduced BCL-2 protective levels, results in apoptosis and therefore decreases the number of melanocytes that could repopulate the newly formed anagenfollicles. Altogether,oxidative stress may contribute to age-inducedhairgraying via multiple pathways. Better understanding of the different processes, sources, and types ofoxidative stress within the follicular environment, and the different susceptibilities of melanocytes tooxidative stress at the different follicular locations, might yield clues to possible interventions for prevention or reversal ofhair graying.

A Free radical theory of graying

Here we provide unique evidence foroxidative stress induced loss of melanocytes from the humanhairfollicle during aging. In detail, we show for the first time that:1)a decreased number of viable melanocytes in the aginghairfollicle bulge and bulb and an increased incidence ofhair bulb melanocyte apoptosis in aging individuals are associated withoxidative stress in the pigmentary unit;2)the aginghairfollicle is characterized by the absence ofoxidative stress-protectors, such as Bcl-2, and melanocytegrowth factors, such as c-Kit;3)a higher frequency ofoxidative stress associated mitochondrial DNA damage occurs ingrayinghairfollicles, while unpigmentedhairfollicles prove to be not “older” than pigmentedhairfollicles;4)melanocytes of the pigmentary unit are highly and selectively susceptible to exogenousoxidative stress damage.One major route, by whichoxidative stress leads to permanent melanocyte damage, appears to pass by the mitochondria, since their DNA is not so well protected as genomic DNA. The accumulation of mutations, therefore, correlates with age and is indicative of general exposure and generation ofoxidative stress, (39⤻, 40)⤻caused for example by psychoemotional stress,inflammation, UV-light, and others. In summary, our findings support the proposed hypothesis of a “free radical theory ofgraying” and suggest that melanocytes in thehairfollicle are highly susceptible to endogenousoxidative stress. Exogenousoxidative stress can trigger and hasten this process and provoke permanent damage selectively and prematurely inhair bulb melanocytes.

Age-related hair pigment loss

Humans are social animals that communicate disproportionately via potent genetic signals imbued in the skin andhair, including racial, ethnic, health, gender, and age status. For the vast majority of us, age-relatedhair pigment loss becomes the inescapable signal of our disappearing youth. Thehairfollicle (HF) pigmentary unit is a wonderful tissue for studying mechanisms generally regulating aging, often before this becomes evident elsewhere in the body. Given that follicular melanocytes (unlike those in the epidermis) are regulated by thehairgrowth cycle, this cycle is likely to impact the process of aging in the HF pigmentary unit. The formal identification of melanocyte stem cells in the mouse skin has spurred a flurry of reports on the potential involvement of melanocyte stem cell depletion inhair graying (i.e., canities). Caution is recommended, however, against simple extrapolation of murine data to humans. Regardless,hair graying in both species is likely to involve an age-related imbalance in the tissue’soxidative stress handling that will impact not only melanogenesis but also melanocyte stem cell and melanocyte homeostasis and survival. There is some emerging evidence that the HF pigmentary unit may have regenerative potential, even after it has begun to produce whitehair fibers. It may therefore be feasible to develop strategies to modulate some aging-associated changes to maintain melanin production for longer.

Chronic inflammation induces telomere dysfunction and accelerates ageing

Chronicinflammation is associated with normal and pathological ageing. Here we show that chronic, progressive low-gradeinflammation induced by knockout of the nfkb1subunit of the transcription factor NF-κB induces premature ageing in mice. We also show that these mice have reduced regeneration in liver and gut. nfkb1−/−fibroblasts exhibit aggravated cell senescence because of an enhanced autocrine and paracrine feedback through NF-κB, COX-2 and ROS, which stabilizes DNA damage. Preferential accumulation of telomere-dysfunctional senescent cells in nfkb1−/−tissues is blocked byanti-inflammatory or antioxidant treatment of mice, and this rescues tissue regenerative potential. Frequencies of senescent cells in liver and intestinal crypts quantitatively predict mean and maximum lifespan in both short- and long-lived mice cohorts. These data indicate that systemic chronicinflammation can accelerate ageing via ROS-mediated exacerbation of telomere dysfunction and cell senescence in the absence of any other genetic or environmental factor.

Repigmentation and new growth of hairs after anti–interleukin-17 therapy

Repigmentation ofhairs is a rare event that has been reported after inflammatory processes, exposure to X-irradiation and psoralen and ultraviolet A, electron beam therapy, and the intake of some drugs. We report on a patient with psoriasis who experienced darkening and noticeable increase in scalphair while he was receiving anti–interleukin (IL)-17 therapy.

Fibroblast growth factor signalling in the hair growth cycle

Using RNA in situ hybridization analysis, we have characterized the expression domains of the four known members of the FGF receptor-tyrosine kinase gene family in the murinehairfollicle at various stages of thehairgrowth cycle. During anagen, we detected Fgfr1 RNA in the dermal papilla, Fgfr2 RNA inhair matrix cells near the dermal papilla, Fgfr3 RNA in pre-cuticle cells in the periphery of thehair bulb, and Fgfr4 RNA in cells in the periphery of thehair bulb and also in the inner and outer root sheath in the lower half of the follicle neck. No RNA expression of these genes was detected during late catagen or telogen. We have previously shown that Fgf5 is expressed in the outer root sheath in the transient portion of thefollicle (Hébert et al. [1994] Cell 78:1017-1025). In the present study we have also assayed for the expression of six other members of the FGF ligand gene family, Fgf3, Fgf4, Fgf6, Fgf7, Fgf8, and Fgf9. Among these FGF genes, only Fgf7 was found to be expressed in thehairfollicle. Fgf7 RNA is localized to the dermal papilla during anagen, but expression is down-regulated by the late-anagen VI stage. We have also demonstrated that addition of FGF5 protein to the culture medium changes the behavior of dermal papilla cells in vitro, indicating that they are capable of responding to FGF5. Together with previously published data, these results provide a complete analysis of FGF ligand and FGF receptor-tyrosine kinase gene expression in thehairfollicle, and suggest that FGF signalling may have several functions in thehair

Hair shaft producing cells were proliferated only in the anagen. Many mediators were involved in starting, sustaining and terminating anagen. Among them, we focused on thegrowth factor FGF-7 and FGF-5. Our results reveal thehair growth enhancing effects of EP were related with the anagen regulatinggrowth factors.mTOR activating the potential of EP in HDPs was signifying that it exerts the positive role in the proliferation of follicular cells during anagen.

Oxidative stress management in the hair follicle: Targeting NRF2

Widespread expression of the transcription factor, nuclear factor (erythroid‐derived 2)‐like 2 (NRF2), which maintains redox homeostasis, has recently been identified in thehairfollicle (HF). Small molecule activators of NRF2 may therefore be useful in the management of HF pathologies associated with redox imbalance, ranging from HFgreying and HF ageing via androgenetic alopecia and alopecia areata to chemotherapy‐inducedhair loss. Indeed, NRF2 activation has been shown to prevent peroxide‐inducedhairgrowth inhibition. Multiple parameters can increase the levels of reactive oxygen species in the HF, for example melanogenesis, depilation‐induced trauma, neurogenic and autoimmuneinflammation, toxic drugs, environmental stressors such as UV irradiation, genetic defects and aging‐associated mitochondrial dysfunction. In this review, the potential mechanisms whereby NRF2 activation could prove beneficial in treatment of redox‐associated HF disorders are therefore discussed.

The impact of oxidative stress on hair

Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system’s ability to detoxify the reactive intermediates or to repair the resulting damage. Reactive oxygen species or free radicals are highly reactive molecules that can directly damage lipids, proteins, and DNA. They are generated by a multitude of endogenous and environmental challenges, while the body possesses endogenous defense mechanisms. With age, production of free radicals increases, while the endogenous defense mechanisms decrease. This imbalance leads to progressive damage of cellular structures, presumably resulting in the aging phenotype. While the role ofoxidative stress has been widely discussed in skin aging, little focus has been placed on its impact on hair condition. Moreover, most literature on age‐relatedhair changes focuses on alopecia, but it is equally important that thehair fibers that emerge from the scalp exhibit significant age‐related changes that have equal impact on the overall cosmetic properties ofhair. Sources ofoxidative stress with impact on the pre‐emerging fiber include: oxidative metabolism, smoking, UVR, andinflammation from microbial, pollutant, or irritant origins. Sources ofoxidative stress with impact on the post‐emerging fiber include: UVR (enhanced by copper), chemical insults, and oxidized scalp lipids. The role of the dermatologist is recognition and treatment of pre‐ and post‐emerging factors for lifetime scalp andhair health.

Repigmentation of hair following adalimumab therapy

Repigmentation of canities, or age-relatedgrey or whitehair, is a rare occurrence. Generalized repigmentation ofgrey-whitehair has been reported following inflammatory processes,[1] and heterochromia (localized patches ofhair repigmentation) is even more unusual, reported in association with medication use and malignancy.Tumor necrosis factor (TNF) inhibitors are increasingly utilized medications for inflammatory disorders, including psoriasis, rheumatoid arthritis, and inflammatory bowel disease.Hair loss, or alopecia, has been described among the side effects of these medications,[2] but changes inhair pigmentation in association with this class of drugs have not previously been reported. We describe a patient withhair repigmentation associated with adalimumab therapy.

A Comment on the Science of Hair Aging

In contrast to the skin, aging of thehair has seemingly only recently found the attention of dermatological meetings, mainly promoted by the cosmetic industry for marketing purposes. In fact, basic scientists interested in the biology ofhairgrowth and pigmentation have for some time already exposed thehairfollicle as a highly accessible model with unique opportunities for the study of age-related effects. As a result, the science ofhair aging focuses on two main streams of interest: the esthetic problem of aginghair and its management, in terms of age-related effects onhair color, quantity, and quality; and the biological problem of aginghair, in terms of microscopic, biochemical, and molecular changes underlying the aging process. Ultimately, the aim ofhair anti-aging is to delay, lessen, or reverse the effects of aging onhair. According to the complex nature of the aging process, the treatment for lifetime scalp andhair health has to be holistic to include the multitude of contributing factors in a polyhedral and patient-specific manner. It comprises both medical treatments andhair cosmetics. Accordingly, the discovery of pharmacological targets and the development of safe and effective drugs for treatment ofhair loss indicate strategies of the drug industry for maintenance ofhairgrowth and quantity, while thehair care industry has become capable of delivering active compounds directed toward meeting the consumer demand for maintenance ofhair cosmesis and quality. “Where there’s life, there’s hope” (Ecclesiastes 9:3-5).

Three Streams for the Mechanism of Hair Graying

Hair graying is an obvious sign of human aging. Althoughgraying has been investigated extensively, the mechanism remains unclear. Here, we reviewed previous studies on the mechanism ofgraying and seek to offer some new insights. The traditional view is thathairgraying is caused by exhaustion of the pigmentary potential of the melanocytes ofhair bulbs. Melanocyte dysfunction may be attributable to the effects of toxic reactive oxygen species on melanocyte nuclei and mitochondria. A recent study suggests that bulge melanocyte stem cells (MSCs) are the key cells in play.Graying may be caused by defective MSC self-maintenance, not by any deficiency in bulbar melanocytes. Our previous study suggested thatgraying may be principally attributable to activehairgrowth. Activehairgrowth may produce oxidative or genotoxic stress inhair bulge. These internal stress may cause eventually depletion of MSC in thehairfollicles. Taken together,hair graying may be caused by MSC depletion by genotoxic stress in thehair bulge.Hair graying may also be sometimes caused by dysfunction of the melanocytes byoxidative stress in thehair bulb. In addition,hair graying may be attributable to MSC depletion by activehairgrowth.

Pharmacologic interventions in aging hair

The appearance ofhair plays an important role in people’s overall physical appearance and self-perception. With today’s increasing life-expectations, the desire to look youthful plays a bigger role than ever. Thehair care industry has become aware of this and is delivering active products directed towards meeting this consumer demand. The discovery of pharmacological targets and the development of safe and effective drugs also indicate strategies of the drug industry for maintenance of healthy and beautifulhair.Hair aging comprises weathering of thehair shaft, decrease of melanocyte function, and decrease inhair production. The scalp is subject to intrinsic and extrinsic aging. Intrinsic factors are related to individual genetic and epigenetic mechanisms with interindividual variation: prototypes are familial prematuregraying, and androgenetic alopecia. Currently available pharmacologic treatment modalities with proven efficacy for treatment of androgenetic alopecia are topical minoxidil and oral finasteride. Extrinsic factors include ultraviolet radiation and air pollution. Experimental evidence supports the hypothesis thatoxidative stress also plays a role inhair aging. Topical anti-aging compounds include photoprotectors and antioxidants. In the absence of another way to reversehair graying,hair colorants remain the mainstay of recovering losthair color. Topical liposome targeting for melanins, genes, and proteins selectively tohairfollicles are currently under investigation.

Hair growth inhibition by psychoemotional stress

Stress has long been discussed controversially as a cause ofhair loss. However, solid proof of stress‐inducedhairgrowth inhibition had long been missing. If psychoemotional stress can affecthairgrowth, this must be mediated via definable neurorendocrine and/or neuroimmunological signaling pathways. Revisiting and up‐dating relevant background data on neural mechanisms ofhairgrowth control, we sketch essentials ofhairfollicle (HF) neurobiology and discuss the modulation of murinehairgrowth by neuropeptides, neurotransmitters, neurotrophins, and mast cells. Exploiting an established mouse model for stress, we summarize recent evidence that sonic stress triggers a cascade of molecular events including plasticity of the peptidergic peri‐ and interfollicular innervation and neuroimmune crosstalk. Substance P (SP) and NGF (nervegrowth factor) are recruited as key mediators of stress‐inducedhairgrowth‐inhibitory effects. These effects include perifollicular neurogenicinflammation, HF keratinocyte apoptosis, inhibition of proliferation within the HF epithelium, and premature HF regression (catagen induction). Intriguingly, most of these effects can be abrogated by treatment of stressed mice with SP‐receptor neurokinin‐1 receptor (NK‐1) antagonists or NGF‐neutralizing antibodies – as well as, surprisingly, by topical minoxidil. Thus there is now solid in vivo‐evidence for the existence of a defined brain‐ HF axis. This axis can be utilized by psychoemotional and other stressors to prematurely terminatehair growth. Stress‐inducedhair growth inhibition can therefore serve as a highly instructive model for exploring the brain‐skin connection and provides a unique experimental model for dissecting general principles of skin neuroendocrinology and neuroimmunology well beyond the HF.

Hair cycle and hair pigmentation ASSOCIATED WITH AGING

The tight coupling ofhairfollicle melanogenesis to thehairgrowth cycle dramatically distinguishes follicular melanogenesis from the continuous melanogenesis of the epidermis. Cyclic re-construction of an intacthairfollicle pigmentary unit occurs optimally in all scalphairfollicles during only the first 10hair cycles, i.e. by approximately 40 years of age. Thereafter there appears to be a genetically regulated exhaustion of the pigmentary potential of each individualhairfollicle leading to the formation of truegray and whitehair. Pigment dilution results primarily from a reduction in tyrosinase activity withinhair bulbar melanocytes. Thereafter, sub-optimal melanocyte–cortical keratinocyte interactions, and defective migration of melanocytes from a reservoir in the upper outer root sheath to the pigment-permitting microenvironment close to the follicular papilla of thehair bulb, will all disrupt normal function of the pigmentary unit. Evidence from studies on epidermal melanocyte aging suggest that reactive oxygen species-mediated damage to nuclear and mitochondrial DNA may lead to mutation accumulation in bulbar melanocytes. Parallel dysregulation of anti-oxidant mechanisms or pro/anti-apoptotic factors is also likely to occur within the cells. Pigment loss in canities may also affect keratinocyte proliferation and differentiation, providing the tantalizing suggestion that melanocytes in thehairfollicle contribute far more that packages of pigment alone. Here, we review the current state of knowledge of the development, regulation and control of the aging humanhairfollicle pigmentary system in relation withhair cycling. The exploitation of recently available methodologies to manipulatehairfollicle melanocytes in vitro, and the observations that melanocytes remain in senile whitehairfollicles that can be induced to pigment in culture, raises the possibility of someday reversing canities. The perspective of rejuvenation of the wholehairfollicle apparatus are still part of the dream but optimising its functional properties is clinically relevant and is close to reality. Finally ashair color influences its visibility when optical methods such as scalp photography are used to counthair fibers, the attention is drawn to possible interpretations of statistically significant changes in visiblehair. Such changes may not exclusively be related to improvedhairgrowth itself but also to changes in naturalhair color that makes thehair more visible with the method used to counthairs.

Human hair pigmentation – biological aspects

Skin and hair colour contribute significantly to our overall visual appearance and to social/sexual communication. Despite their shared origins in the embryologic neural crest, thehairfollicle and epidermal pigmentary units occupy distinct, although open, cutaneous compartments. They can be distinguished principally on the basis of the former’s stringent coupling to thehairgrowth cycle compared with the latter’s continuous melanogenesis. The biosynthesis of melanin and its subsequent transfer from melanocyte tohair bulb keratinocytes depend on the availability of melanin precursors and on a raft of signal transduction pathways that are both highly complex and commonly redundant. These signalling pathways can be both dependent and independent of receptors, act through auto‐, para‐ or intracrine mechanisms and can be modified by hormonal signals. Despite many shared features, follicular melanocytes appear to be more sensitive than epidermal melanocytes to ageing influences. This can be seen most dramatically inhair greying/canities and this is likely to reflect significant differences in the epidermal and follicular microenvironments. Thehairfollicle pigmentary unit may also serve as an important environmental sensor, wherebyhair pigment contributes to the rapid excretion of heavy metals, chemicals and toxins from the body by their selective binding to melanin; rendering thehair fibre a useful barometer of exposures. The recent availability of advanced cell culture methodologies for isolatedhairfollicle melanocytes and for intact anagenhairfollicle organ culture should provide the research tools necessary to elucidate the regulatory mechanisms ofhairfollicle pigmentation. In the longer term, it may be feasible to develophair colour modifiers of a biological nature to accompany those based on chemicals.

Histopathology of aging of the hair follicle

Hairfollicles experience several changes with aging, the most noticeable of which isgraying of thehair shaft due to loss of melanin. Additional changes in the diameter and length of thehair have contributed to the concept of senescent alopecia, which is different from androgenetic alopecia according to most.Graying happens in most individuals, although in different grades and starting at different ages. It is related to a decrease in the number and activity of the melanocytes of thehair bulb, which eventually completely disappear from the bulb of the whitehair. Residual non‐active melanocytes remain in the outer root sheath and in the bulge, which allows for repigmentation of thehair under certain stimuli or conditions.

the etiologies, clinical characteristics, and treatment of grey hair

Hair pigmentation is regulated by follicular melanogenesis, in which the process consists of melanin formation and transfer to keratinocytes in thehair shaft. Humanhairfollicles contain two types of melanin: the brown‐black eumelanin and yellow‐red pheomelanin. Eumelanin is commonly present in black and brownhair while pheomelanin is found in auburn and blondehair.Hairfollicle melanogenesis is under cyclical control and is concurrently coupled tohairgrowth. Many factors including intrinsic and extrinsic factors affect the follicular melanogenesis. Though many studies have been conducted to identify the pathogenesis and regulation ofhair pigmentation, the etiology of canities andhair pigmentation is still unclear. The pathogenesis of canities orgray hair is believed to occur either from insufficient melanin formation due to melanocyte degeneration or a defect in melanosomal transfer. Canities is an aging sign which often interferes with one’s socio‐cultural adjustment. On the other hand, premature canities correlate with diseases such as osteopenia and cardiovascular disease. Risk factors associated with canities are not only genetic but also external causes. For example, smoking, alcohol consumption, and stress are among the most common factors. Camouflage techniques are still used as the primary treatment of canities. Further treatments for canities are being developed to achieve the true reversal ofhair pigmentation.

Aging of the Hair Follicle Pigmentation System

Skin andhair phenotypes are powerful cues in human communication. They impart much information, not least about our racial, ethnic, health, gender and age status. In the case of the latter parameter, we experience significant change in pigmentation in our journey from birth to puberty and through to young adulthood, middle age and beyond. Thehairfollicle pigmentary unit is perhaps one of our most visible, accessible and potent aging sensors, with marked dilution of pigment intensity occurring long before even subtle changes are seen in the epidermis. This dichotomy is of interest as both skin compartments contain melanocyte subpopulations of similar embryologic (i.e., neural crest) origin. Research groups are actively pursuing the study of the differential aging of melanocytes in thehair bulb versus the epidermis and in particular are examining whether this is in part linked to the stringent coupling of follicular melanocytes to the hairgrowth cycle. Whether some follicular melanocyte subpopulations are affected, like epidermal melanocytes, by UV irradiation is not yet clear. A particular target of research intohair graying or canities is the nature of the melanocyte stem compartment and whether this is depleted due to reactive oxygen species-associated damage, coupled with an impaired antioxidant status, and a failure of melanocyte stem cell renewal. Over the last few years, we and others have developed advanced in vitro models and assay systems for isolatedhairfollicle melanocytes and for intact anagenhairfollicle organ culture which may provide research tools to elucidate the regulatory mechanisms ofhairfollicle pigmentation. Long term, it may be feasible to develop strategies to modulate some of these aging-associated changes in thehairfollicle that impinge particularly on the melanocyte populations.

Dihydrotestosterone-inducible IL-6 inhibits elongation of human hair shafts by suppressing matrix cell proliferation and promotes regression

Cytokines and Other Mediators in Alopecia Areata

Alopecia areata, a disease of the hair follicles with multifactorial etiology and a strong component of autoimmune origin, has been extensively studied as far as the role of several cytokines is concerned. So far, IFN-, interleukins, TNF-, are cytokines that are well known to play a major role in the pathogenesis of the disease, while several studies have shown that many more pathways exist. Among them, MIG, IP-10, BAFF, HLA antigens, MIG, as well as stress hormones are implicated in disease onset and activity. Within the scope of this paper, the authors attempt to shed light upon the complexity of alopecia areata underlying mechanisms and indicate pathways that may suggest future treatments.

INGREDIENTS & SCIENCE

  1. Antioxidant and Anti-InflammatoryActivitiesof the Plant Andrographis PaniculataNees
  2. Anti-inflammatoryActivityof New Compounds from Andrographis paniculataby NF-κB Transactivation Inhibition
  3. Inhibitory effect of andrographolidefrom Andrographis paniculataon PAF-induced platelet aggregation
  4. Study of anti-inflammatoryactivitiesof the pure compounds from Andrographis paniculata(burm.f.) Nees and their effects on gene expression
  5. Effect of an extract of Andrographis paniculataleaves on inflammatoryand allergic mediatorsin vitro
  6. AP-1/IRF-3 Targeted Anti-InflammatoryActivityof Andrographolide Isolated from Andrographis paniculata
  7. Antiangiogenic activity of Andrographis paniculataextract and andrographolide
  8. In vitro modulation of LPS/calcimycin induced inflammatoryand allergic mediatorsby pure compounds of Andrographis paniculata(King of bitters) extract
  9. Inhibitory Effects of Ethyl Acetate Extract of Andrographis paniculataon NF-κB Trans-Activation Activity and LPS-Induced Acute Inflammationin Mice
  10. Andrograpanin, a compound isolated from anti‐inflammatorytraditional Chinese medicine Andrographis paniculata, enhances chemokine SDF‐1α‐induced leukocytes chemotaxis
  11. An in vitro study of anti-inflammatoryactivityof standardised Andrographis paniculata extractsand pure andrographolide
  12. Andrograpanin, isolated from Andrographis paniculata,exhibits anti-inflammatorypropertyin lipopolysaccharide-induced macrophage cells through down-regulating the p38 MAPKs signaling pathways
  13. Review on Liver Inflammationand Antiinflammatory Activityof Andrographis paniculatafor Hepatoprotection
  14. Effect of noni (Morinda citrifolia ) and fahtalaijons (Andrographis paniculata) on pigmentationand phagocytosis in goldfish (Carasius auratus)
  15. 5α-reductase inhibition and hairgrowthpromotionof some Thai plantstraditionally used for hairtreatment
  16. The anti-inflammatoryeffect of Andrographis paniculata(Burm. f.) Nees on pelvic inflammatorydisease in rats through down-regulation of the NF-κB pathway
  17. Antioxidant, antinociceptive and anti-inflammatorypropertiesof the aqueous and ethanolic leaf extracts of Andrographis paniculatain some laboratory animals
  18. Green approach for synthesis of zinc oxide nanoparticles from Andrographis paniculata leaf extractand evaluation of their antioxidant, anti-diabetic, and anti-inflammatoryactivities
  19. Andrographolide, a potential cancer therapeutic agentisolated from Andrographis paniculata
  20. Antioxidant and gastroprotective activitiesof Andrographis paniculata(Hempedu Bumi) in Sprague Dawley rats
  21. In Vitro Comparative Evaluation of Non-Leaves and Leaves Extracts of Andrographis paniculataon Modulation of InflammatoryMediators
  22. Protective Effects of Andrographis paniculata Extractand Pure Andrographolide Against Chronic Stress-Triggered Pathologies in Rats
  23. Andrographispaniculata Downregulates Proinflammatory Cytokine Productionand Augments Cell Mediated Immune Response in Metastatic Tumor-Bearing Mice
  24. Rapid extraction of andrographolide from Andrographis paniculataNees by three phase partitioning and determination of its antioxidant activity
  25. Andrographis paniculata(Burm. f.) Wall. ex Nees (kalmegh), a traditional hepatoprotective drug from India
  26. ANDROGRAPHIS PANICULATAAND ITS BIOACTIVE PHYTOCHEMICAL CONSTITUENTS FOR OXIDATIVE DAMAGE: A SYSTEMIC REVIEW
  27. Andrographolide, a major component of Andrographis paniculata leaves, has the neuroprotective effectson glutamate-induced HT22 cell death
  28. Study on the pharmacokinetics of Andrographis paniculata Nees’s anti-inflammatoryeffect
  29. Hepatoprotective Effectof the Aqueous Leaf Extract of Andrographis paniculataNees Against Carbon Tetrachloride – Induced Hepatotoxicity in Rats
  30. Water Fraction Of Sambiloto (Andrographis Paniculata Nees) Ethanol Extract Efficacy In Inducing The Number Of Macrophage, Neutrophil, And The Level Of TNF-α On Wistar Rats
  31. Pengaruh ekstrak air herba sambiloto (andrographis paniculata) dan daun salam (syzygium polyanthum) terhadap jumlah tnf-α, makrofag dan neutrofil pada tikus yang diinduksi aloksan
  32. Effect of Andrographis Paniculata to the Expression of IL-6, IL-17, IL-10, TGFß, and the Ratio of Treg
  33. Effect of Andrographis Paniculata to the Expression of IL-6, IL-17, IL-10, TGFβ, and the Ratio of Treg/ Th17 in Sprague Dawley Rats with Atherosclerosis Diet an dCigarette Smoke

  1. Inhibitory Effect of Apigenin, a Plant Flavonoid, on Epidermal Ornithine Decarboxylase and Skin TumorPromotion in Mice
  2. Inhibition of ultraviolet light induced skincarcinogenesis in SKH-1 mice by apigenin, a plant flavonoid.
  3. Enhanced in vitro and in vivo skindeposition of apigenindelivered using ethosomes
  4. Skin anti-inflammatoryactivity of apigenin-7-glucoside in rats.
  5. Production and characterization of antioxidant apigeninnanocrystals as a novel UV skinprotective formulation
  6. Src kinase is a direct target of apigeninagainst UVB-induced skininflammation
  7. ApigeninReactivates Nrf2 Anti-oxidative StressSignaling in Mouse Skin Epidermal JB6 P + Cells Through Epigenetics Modifications
  8. In Vivo and In Vitro Percutaneous Absorption of Cancer Preventive Flavonoid Apigeninin Different Vehicles in Mouse Skin
  9. Inhibition of mTORby apigeninin UVB-irradiated keratinocytes: A new implication of skincancer prevention
  10. Efficacy of PLGA-loaded apigeninnanoparticles in Benzo[a]pyrene and ultraviolet-B induced skincancer of mice: Mitochondria mediated apoptotic signalling cascades
  11. Dietary apigeninattenuates the development of atopic dermatitis-like skinlesions in NC/Nga mice
  12. Strategic formulation of apigenin-loaded PLGA nanoparticles for intracellular trafficking, DNA targeting and improved therapeutic effects in skinmelanoma in vitro
  13. Influence of Vehicle, Distant Topical Delivery, and Biotransformation on the Chemopreventive Activity of Apigenin, a Plant Flavonoid, in Mouse Skin
  14. Anti-inflammatoryactivity of structurally related flavonoids, Apigenin, Luteolinand Fisetin
  15. Anti-InflammatoryEffects of Apigeninin Lipopolysaccharide-Induced Inflammatoryin Acute Lung Injury by Suppressing COX-2 and NF-kB Pathway
  16. Decreased pro-inflammatory cytokineproduction by LPS-stimulated PBMC upon in vitro incubation with the flavonoids apigenin, luteolin or chrysin, due to selective elimination of monocytes/macrophages
  17. Anti-inflammatorymechanisms of apigenin: inhibition of cyclooxygenase-2 expression, adhesion of monocytes to human umbilical vein endothelial cells, and expression of cellular adhesion molecules
  18. Apigenininhibits allergen-induced airway inflammationand switches immune response in a murine model of asthma
  19. Dietary phytophenols curcumin, naringenin and apigeninreduce infection-induced inflammatoryand contractile pathways in human placenta, foetal membranes and myometrium
  20. Apigenininhibits release of inflammatorymediators by blocking the NF-κB activation pathways in the HMC-1 cells
  21. ApigeninBlocks Lipopolysaccharide-Induced Lethality In Vivo and ProinflammatoryCytokines Expression by Inactivating NF-κB through the Suppression of p65 Phosphorylation
  22. Modulation of lipopolysaccharide-induced proinflammatory cytokineproduction in vitro and in vivo by the herbal constituents apigenin(chamomile), ginsenoside Rb1 (ginseng) and parthenolide (feverfew)
  23. Dietary ApigeninSuppresses IgE and InflammatoryCytokinesProduction in C57BL/6N Mice
  24. Apigenininhibits PMA-induced expression of pro-inflammatory cytokinesand AP-1 factors in A549 cells
  25. ApigeninAttenuates Experimental Autoimmune Myocarditis by Modulating Th1/Th2 CytokineBalance in Mice
  26. Effect of parsley (Petroselinum crispum) intake on urinary apigeninexcretion, blood antioxidant enzymes and biomarkers for oxidative stressin human subjects
  27. Apigeninprotects endothelium-dependent relaxation of rat aorta against oxidative stress
  28. Apigenininhibits oxidative stress‐induced macromolecular damage in N‐nitrosodiethylamine (NDEA)‐induced hepatocellular carcinogenesis in Wistar albino rats
  29. Oxidative stresstriggered by naturally occurring flavone apigeninresults in senescence and chemotherapeutic effect in human colorectal cancer cells
  30. Exposure of breast cancer cells to a subcytotoxic dose of apigenincauses growthinhibition, oxidative stress, and hypophosphorylation of Akt
  31. Apigenin, a non-mutagenic dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation for expansion of autoreactive Th1 and Th17cells
  32. Apigeninprotects ovalbumin-induced asthma through the regulation of Th17cells
  33. The IL-23/IL-17axisin inflammation
  34. Apigenin Suppresses the IL-1β-Induced Expression of the Urokinase-Type Plasminogen Activator Receptor by Inhibiting MAPK-Mediated AP-1 and NF-κB Signaling in Human Bladder Cancer T24 Cells
  35. Inhibitory effect of apigenin on nitric oxide production in chondrocytes induced by IL-1 and LPS
  36. Inhibition of IL-6/STAT3 axis and targeting Axl and Tyro3 receptor tyrosine kinases by apigenin circumvent taxol resistance in ovarian cancer cells
  37. Apigenin Inhibits the Expression of IL-6, IL-8, and ICAM-1 in DEHP-Stimulated Human Umbilical Vein Endothelial Cells and In Vivo
  38. Apige nin inh ib its indoxyl sul fate-inducedend opla smic reti culum stress andan ti -pro lif era tive pat hways, CHOP and IL -6/p 21, in hu man renal proxim al t ubu lar c
  39. Antitumor and Anti-Invasive Effect of Apigenin on Human Breast Carcinoma through Suppression of IL-6Expression
  40. Sa1794 Apigenin Attenuates Cerulein-Induced Parathyroid Hormone-Related Protein (PTHrP) and IL-6in a Model of Murine Pancreatitis
  41. 5,6-Dichloro-ribifuranosylbenzimidazole- and apigenin-induced sensitization of colon cancer cells to TNF-α-mediated apoptosis
  42. Effect of apigenin, kaempferol and resveratrol on the gene expression and protein secretion of tumor necrosis factor alpha (TNF-α) and interleukin-10 (IL-10) in RAW-264.7 macrophages
  43. Apigenin prevents TNF-α induced apoptosis of primary rat retinal ganglion cells.
  44. Differential response to apigenin in African American triple-negative breast cancer in reducing TNF-α mediated rise in CXCL1
  45. Apigenin Exerts Anti-inflammatory Effects in an Experimental Model of Acute Pancreatitis by Down-regulating TNF-α

  1. Cosmetic composition for skinwhitening comprising arctiin, arctigenin or the mixture thereof as active
  2. Anti-agingagent containing arctigenin derivative
  3. Arctigenin exerts anti-colitis efficacy through inhibiting the differentiation of Th1 and Th17cells via an mTORC1-dependent pathway
  4. Arctigenin Suppress Th17 Cellsand Ameliorates Experimental Autoimmune Encephalomyelitis Through AMPKand PPAR-γ/ROR-γt Signaling
  5. Arctigenin functions as a selective agonist of estrogen receptor β to restrict mTORC1 activation and consequent Th17differentiation
  6. Arctigenin attenuates imiquimod-induced psoriasis-like skinlesions via down-regulating keratin17
  7. Arctigenin regulates Th1 and Th17differentiation and ameliorates experimental autoimmune encephalomyelitis (THER7P.958)
  8. Arctigenin improves vascular tone and decreases inflammationin human saphenous vein
  9. Arctigenin inhibits lipopolysaccharide-induced iNOS expression in RAW264.7 cellsthrough suppressing JAK-STAT signal pathway
  10. Arctigenin , a phenylpropanoid dibenzylbutyrolactone lignan, inhibits type I–IV allergic inflammationand pro-inflammatoryenzymes
  11. Arctigenin Treatment Protects against Brain Damage through an Anti-Inflammatoryand Anti-Apoptotic Mechanism after Needle Insertion
  12. Arctigenin Protects against Lipopolysaccharide-Induced Pulmonary Oxidative Stressand Inflammationin a Mouse Model via Suppression of MAPK, HO-1, and iNOS Signaling
  13. Anti-inflammatoryactivity of arctigenin from Forsythiae Fructus
  14. Arctigenin ameliorates inflammationin vitro and in vivo by inhibiting the PI3K/AKT pathway and polarizing M1 macrophages to M2-like macrophages
  15. Arctigenin but not arctiin acts as the major effective constituent of Arctium lappa L. fruit for attenuating colonicinflammatoryresponse induced by dextran sulfate sodium in mice
  16. Arctigenin from Arctium lappa inhibits interleukin-2and interferon gene expression in primary human T lymphocytes
  17. Arctigenin improves vascular tone and decreases inflammationin human saphenous vein
  18. Anti-inflammatoryactivity of arctigenin from Forsythiae Fructus
  19. In vitro anti-inflammatoryeffects of arctigenin , a lignan from Arctium lappa L., through inhibition on iNOS pathway
  20. Arctigenin ameliorates inflammationin vitro and in vivo by inhibiting the PI3K/AKT pathway and polarizing M1 macrophages to M2-like macrophages
  21. Arctigenin , a phenylpropanoid dibenzylbutyrolactone lignan, inhibits type I–IV allergic inflammationand pro-inflammatory enzymes
  22. Arctigenin Protects against Lipopolysaccharide-Induced Pulmonary Oxidative Stressand Inflammationin a Mouse Model via Suppression of MAPK, HO-1, and iNOS Signaling
  23. Arctigenin protects focal cerebral ischemia-reperfusion rats through inhibiting neuroinflammation
  24. Arctigenin , a Natural Lignan Compound, Induces Apoptotic Death of Hepatocellular Carcinoma Cells via Suppression of PI3‐K/Akt Signaling
  25. β-Catenin Mediates Anti-adipogenicand Anticancer Effects of arctigenin in Preadipocytes and Breast Cancer Cells
  26. Protective Effects of arctigenin and Arctiin in H_2O_2-Treated SHSY_5Y Cells
  27. Arctigenin suppresses inflammationand plays a neuroprotective effect in mice with spinal cord injury
  28. Arctigenin exerts protective effects against myocardial infarction via regulation of iNOS, COX‑2, ERK1/2 and HO‑1in rats
  29. Arctigenin Ameliorates Inflammationby Regulating Accumulation and Functional Activity of MDSCs in Endotoxin Shock
  30. Overview of the anti-inflammatoryeffects, pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa L

  1. The hairgrowthpromoting effectof Asiasari radix extractand its molecular regulation
  2. KESHARAJA: HAIRVITALIZING HERBS
  3. Aqueous extract of Asiasari radix inhibits formalin-induced hyperalgesia via NMDA receptors
  4. Comparative HairRestorer Efficacyof Medicinal Herb on Nude (Foxn) Mice
  5. HairGrowth: Focus on Herbal Therapeutic Agent
  6. Plants used for hairgrowthpromotion:A review
  7. Regulatory Effect of InflammatoryReaction of Asiasari Radix
  8. Phytochemical, Toxicological and Pharmacological Studies of Asiasari Radixet Rhizoma: A Review
  9. HairLoss and the Applied Techniques for Identification of Novel HairGrowthPromoters for HairRe-Growth
  10. Medical Treatment of HairLoss
  11. HairGrowth-Promoting Effectsin C57BL/6 Mice
  12. Anti-oxidation and Anti-inflammatoryEffect of Asiasari Radixin RAW 264.7 Cells
  13. Partially purified Asiasari radix inhibits melanogenesisthrough extracellular signal-regulated kinase signaling in B16F10 cells
  14. Effect of Aqueous Extract from Asiasari Radixon α
    -melanocyte Stimulating Hormone InducedMelanogenesis in B16F10 Melanoma Cells
  15. Study on Advances of Medicine and Its Active Ingredient on the HairFollicleof Different Animals
  16. Studies on Antitussive Principles of Asiasari Radix
  17. Effects of Asiasari radixon the morphology and viability of mesenchymal stem cells derived from the gingiva
  18. Protection of brain cells against AMPA‐induced damage by Asiasari radix extracts
  19. Study of components in crude drugs by head space gas chromatography. I. Components of Asiasari radix
  20. Composition containing Asiasari Radix extractsfor protecting brain cells and improving memory
  21. Studies of Inhibitory Mechanism on Melanogenesis by Partially Purified Asiasari radixin α-MSH Stimulated B16F10 Melanoma Cells
  22. Asiasari radixwas demonstrated to stimulate hairgrowthin C57BL/6 and C3H mice by increasing the proliferation of HaCaT and human dermal papilla cells (DPCs) and inducing the expression of VEGF in human DPCs
  23. Studies of Inhibitory Mechanism on Melanogenesis by Partially Purified Asiasari radix in α-MSH
  24. Isolation of Five Compounds from Asiasari Radix
  25. Effects of aqueous extracts from Asiasari Radixon α-melnocyte stimulating hormone induced melanogenesis in B16F10 mouse melanoma cell
  26. Alternative Medicine for HairLoss
  27. Anticancer potential of an ethanol extract of Asiasari radixagainst HCT-116 human colon cancer cells in vitro
  28. Isolation of a cytotoxic agent from Asiasari Radix
  29. Insulin inhibits AMPA-induced neuronal damage via stimulation of protein kinase B (Akt)
  30. Immunopharmacological studies on the anti-allergic actions of traditional Chinese medicines and related components

  1. Radix Astragaliinjection enhances recovery from acute acoustic trauma
  2. Inhibitory activities against testosterone 5α-reductase and its hairgrowthpromotion activities
  3. Review of Astragali Radix
  4. New Isoflavonoid Glycosides and Related Constituents from Astragali Radix(Astragalus membranaceus) and Their Inhibitory Activity on Nitric Oxide Production
  5. Comparative analysis of multiple representative components in the herb pair Astragali Radix-CurcumaeRhizoma and its single herbs by UPLC-QQQ-MS
  6. Astragali radix: could it be an adjuvant for oxaliplatin-induced neuropathy?
  7. Effects of Traditional Chinese Medicine Huangqi Injection (Radix astragali)on Random Skin Flap Survival in Rats
  8. Radix astragaliinjection enhances recovery from sudden deafness
  9. Herbal composition for the treatment of alopecia
  10. Hairgrowershaving actions of promoting proliferation of hairpapilla cells
  11. The Effects of Shi-Quan-Dai-Bu-Tang and Its Ingredients on the Survival of Jejunal Crypt Cells and Hematopoietic Cells in Irradiated Mice
  12. Hairgrowtheffectof traditional Chinese medicine BeauTop on androgenetic alopecia patients: A randomized double-blind placebo-controlled clinical trial
  13. Effect of Herbal Medicines Pharmacopuncture on HairGrowth,a Review of Animal Study Reports Published in Koreae
  14. Medical herb composition for promoting the growthof hairA mammal and the manufacturing method thereof
  15. Astragali Radix elicits anti-inflammationvia activation of MKP-1, concomitant with attenuation of p38 and Erk
  16. Pro-inflammatory cytokine gene expressionand nitric oxide regulation of aqueous extracted Astragali radixin RAW 264.7 macrophage cells
  17. Effect of Astragali Radix Extracton Lipopolysaccharide-Induced Inflammationin Human Amnion
  18. Synergistic interaction between Astragali Radixand Rehmanniae Radix in a Chinese herbal formula to promote diabetic wound healing
  19. Chinese medicinal herb Radix Astragalisuppresses cardiac contractile dysfunction and inflammationin a ratmodel of autoimmune myocarditis
  20. Protective effect of Astragali radix extracton interleukin 1β‐induced inflammationin human amnion
  21. Wound-healing activity of Astragali Radix in rats.
  22. Alleviation of osteoarthritis by calycosin-7-O-β-d-glucopyranoside (CG) isolated from Astragali radix (AR)in rabbit osteoarthritis (OA) model
  23. Isolation of Hyaluronidase Inhibitory Component from the Roots of Astraglus membranaceus Bunge (Astragali Radix)
  24. Anti-atherosclerotic function of Astragali Radix extract:downregulation of adhesion molecules in vitro and in vivo
  25. Inhibitory Effect of Astragali Radix on Matrix Degradation in Human Articular Cartilage
  26. Phenolic Derivatives from Radix Astragaliand their Anti-inflammatoryActivities
  27. Immune-enhancing effect of Danggwibohyeoltang, an extract from Astragali Radixand Angelicae gigantis Radix, in vitro and in vivo
  28. Immunomodulatory Effect of Astragali Radix Extracton Murine Th1/Th2 Cell Lineage Development
  29. Transcriptional profiling of human skin fibroblast cell lineHs27 induced by herbal formula Astragali Radixand Rehmanniae Radix
  30. Ethanolic Extract of Astragali Radixand Salviae Radix Prohibits Oxidative Brain Injury by Psycho-Emotional Stress in Whisker Removal Rat Model
  31. Effect on TNF-α,IL-1 and IL-6of Viral Myocarditis Treated by Radix Astragali Injection
  32. Effects of Radix astragali inoculation fluid on serum TNF-α and ET-1 levels in patients with acute cerebral infarction and significance.
  33. The effects of Radix astragali on TNF-α, IL-6in serum of infants with rotavirus enteritis
  34. Effect of Acupuncture and Radix Astragali aqua-acupuncture at Synsu(BL23) on transcriptional expression of mouse cytokine IL-6

  1. Baicalin inhibits IL-17-mediated joint inflammationin murine adjuvant-induced arthritis
  2. Identification of Baicalin as an Immunoregulatory Compound by Controlling TH17 Cell Differentiation
  3. Baicalin Alleviates Silica-Induced Lung Inflammationand Fibrosis by Inhibiting the Th17 Responsein C57BL/6 Mice
  4. Baicalin inhibits IgG production by regulating Treg/Th17 axisin a mouse model of red blood cell transfusion
  5. Identification of Baicalin as an Immunoregulatory Compound by Controlling TH17 Cell Differentiation
  6. Baicalin Attenuates IL-17-MediatedAcetaminophen-Induced Liver Injury in a Mouse Model
  7. Baicalin attenuates TNBS-induced colitis in rats by modulating the Th17/Treg paradigm
  8. Baicalin Alleviates Silica-Induced Lung Inflammationand Fibrosis by Inhibiting the Th17Response in C57BL/6 Mice
  9. Regulatory effect of Baicalin on the imbalance of Th17/Treg responsesin mice with allergic asthma
  10. Study on the inhibitory activity, in vitro, of baicalein and Baicalin against skin fungiand bacteria
  11. Baicalin protects human skin fibroblastsfrom ultraviolet A radiation-induced oxidative damageand apoptosis
  12. Baicalin modulates microRNA expression in UVB irradiated mouse skin
  13. Effect of low molecular weight chitosans on drug permeation through mouse skin: 1. Transdermal delivery of Baicalin
  14. Evaluation of efficacy and tolerance of a nighttime topical antioxidant containing resveratrol, Baicalin , and vitamin e for treatment of mild to moderately photodamaged skin.
  15. The Effects of Baicalin Against UVA-Induced Photoaging in Skin Fibroblasts
  16. Protective effect of Baicalin against multiple ultraviolet b exposure-mediated injuries in C57BL/6 mouse skin
  17. Baicalin attenuates global cerebral ischemia/reperfusion injury in gerbils via anti-oxidativeand anti-apoptotic pathways
  18. Effects of dietary Baicalin supplementation on iron overload-induced mouse liver oxidative injury
  19. The flavonoid Baicalin counteracts ischemic and oxidative insultsto retinal cells and lipid peroxidation to brain membranes
  20. Baicalin prevents the production of hydrogen peroxide and oxidative stressinduced by Aβ aggregation in SH-SY5Y cells
  21. Baicalin protects human skinfibroblasts from ultraviolet A radiation-induced oxidative damageand apoptosis
  22. Baicalin Attenuates Alcoholic Liver Injury through Modulation of Hepatic Oxidative Stress, Inflammation and Sonic Hedgehog Pathway in Rats
  23. Short-term feeding of Baicalin inhibits age-associated NF-κB activation
  24. Baicalin ameliorates isoproterenol-induced acute myocardial infarction through iNOS, inflammation, oxidative stressand P38MAPK pathway in rat
  25. Baicalin attenuates oxygen-glucose deprivation-induced injury by inhibiting oxidative stress-mediated 5-lipoxygenase activation in PC12 cells
  26. Baicalin protects PC-12 cells from oxidative stressinduced by hydrogen peroxide via anti-apoptotic effects
  27. Baicalin prevents cadmium induced hepatic cytotoxicity, oxidative stressand histomorphometric alterations
  28. Baicalin ameliorates isoproterenol-induced acute myocardial infarction through iNOS, inflammationand oxidative stressin rat
  29. Protective Effects of Baicalin on Aβ1–42-Induced Learning and Memory Deficit, Oxidative Stress, and Apoptosis in Rat
  30. The Protective Effect of Baicalin Against Lead-Induced Renal Oxidative Damagein Mice
  31. Study of the Effect of Baicalin and Its Natural Analogs on Neurons with Oxygen and Glucose Deprivation Involving Innate Immune Reaction of TLR2/TNF ?
  32. Baicalin Downregulates Porphyromonas gingivalis Lipopolysaccharide-Upregulated IL-6and IL-8 Expression in Human Oral Keratinocytes by Negative Regulation of TLR Signaling
  33. Baicalin and Baicalein Inhibit Src Tyrosine Kinase and Production of IL-6
  34. Baicalin Ameliorates Dysimmunoregulation in Pristane-Induced Lupus Mice: Production of IL-6and PGE2 and Activation of T cells
  35. Effects of baicalin on TNF-α, IL-6and IL-10 in rats with severe acute pancreatitis.
  36. A Study of Baicalin Inhibiting the Activation of NF-kB and Synthesise of IL-6in Systemic Inflammatory Response Syndrome
  37. Inhibitory effects of baicalin on IL-1β- induced MMP-1/TIMP-1 and its stimulated effect on Collagen-I production in human periodontal ligament cells
  38. The anti‐inflammatory effect of baicalin on hypoxia/reoxygenation and TNF‐α induced injury in cultural rat cardiomyocytes
  39. Effects of Baicalin and Octreotide on the Serum TNF-α Level and Apoptosis in Multiple Organs of Rats with Severe Acute Pancreatitis
  40. Influence of baicalin on TNF-α mRNA, caspase-3 and P-selectin expression in pancreatic tissue of rats with severe acute pancreatitis
  41. Analysis of Influence of Baicalin Joint Resveratrol Retention Enema on the TNF-α, SIgA, IL-2, IFN-γ of Rats with Respiratory Syncytial Virus Infection
  42. Baicalin protects against TNF-α-induced injury by down-regulating miR-191a that targets the tight junction protein ZO-1 in IEC-6 cells
  43. Effects of Baicalin on Apoptosis of Early Chorionic Trophoblast Cell Cultures Induced by Exosomatic TNF-α
  44. Effects of Baicalin on the expression of TNF-α, IL-1β in cerebraltissue after local cerebral ischemia-reperfusion in rats
  45. Baicalin suppresses NLRP3 inflammasome and nuclear factor-kappa B (NF-κB) signaling during Haemophilus parasuis infection
  46. Baicalin inhibitednuclear factor κB (NF-κB) activation and attenuatedsodium taurocholate of induced experimental pancreatitis in rats

  1. Suppression ofinterleukin 17production byBrazilian propolisin mice with collagen-induced arthritis
  2. Brazilian propolisinhibits the differentiation ofTh17 cellsby inhibition of interleukin-6-induced phosphorylation of signal transducer and activator of transcription 3
  3. Neovestitol, an isoflavonoid isolated fromBrazilian red propolis, reduces acute and chronic inflammation: involvement ofnitric oxide andIL-6
  4. Brazilian propolisameliorates trinitrobenzene sulfonic acid-induced colitis in mice by inhibitingTh1 differentiation
  5. Brazilian Green Propolis:Anti-InflammatoryPropertyby an Immunomodulatory Activity
  6. Antinociceptive andanti-inflammatoryeffectsofBrazilian red propolisextract and formononetin in rodents
  7. AntimicrobialBrazilian Propolis(EPP-AF) Containing Biocellulose Membranes as Promising Biomaterial forSkin Wound Healing
  8. Propolis effect on Th1/Th2 cytokinesproduction by acutely stressed mice
  9. Nitric Oxide and Brazilian PropolisCombined Accelerates Tissue Repair by Modulating Cell Migration, Cytokine Production and Collagen Deposition in Experimental Leishmaniasis
  10. Stimulatory Effect ofBrazilian PropolisonHairGrowththrough Proliferation of Keratinocytes in Mice
  11. Brazilian green propolisimproves immune function inaged mice
  12. Brazilian propolisprotects Saccharomyces cerevisiae cells against oxidative stress
  13. Evaluation of the Potential ofBrazilian Propolisagainst UV-Induced Oxidative Stress
  14. Green Brazilian propoliseffects on sperm count and epididymis morphology andoxidative stress
  15. Baccharis dracunculifolia, the main source ofgreen propolis, exhibits potent antioxidant activity and preventsoxidative mitochondrial damage
  16. Anti-Inflammatoryand Antimicrobial Evaluation of Neovestitol and Vestitol Isolated fromBrazilian Red Propolis
  17. Propolis: a review of its anti-inflammatoryand healing actions
  18. TopicalBrazilian propolisimproves corneal wound healing and inflammationin rats following alkali burns
  19. Aqueous Extract ofBrazilian Green Propolis: Primary Components, Evaluation of Inflammationand Wound Healing by Using Subcutaneous Implanted Sponges
  20. Chemical Composition and Anti-InflammatoryEffect of Ethanolic Extract ofBrazilian Green Propolison Activated J774A.1 Macrophages
  21. PropolisInduces Analgesic and Anti-inflammatoryEffects in Mice and Inhibits In Vitro Contraction of Airway Smooth Muscle
  22. Brazilian green propolismodulates inflammation, angiogenesis and fibrogenesis in intraperitoneal implant in mice
  23. Propolisimmunomodulatory action in vivo on Toll‐like receptors 2 and 4 expression and onpro‐inflammatory cytokinesproduction in mice
  24. Propolisand its constituent caffeic acid suppress LPS-stimulatedpro-inflammatoryresponse by blocking NF-κB and MAPK activation in macrophages
  25. Brazilian Red PropolisAttenuatesInflammatorySignaling Cascade in LPS-Activated Macrophages
  26. Molecular Mechanisms Underlying the In Vitro Anti-InflammatoryEffects of a Flavonoid-Rich Ethanol Extract from ChinesePropolis(Poplar Type)
  27. Chemical Characterization andAntioxidant, Antimicrobial,and Anti-InflammatoryActivities of South Brazilian Organic Propolis
  28. Chemical Constituents ofBrazilian Propolisand TheirCytotoxic Activities
  29. Two Novel Cytotoxic Benzofuran Derivatives fromBrazilian Propolis
  30. Correlation analysis between phenolic levels ofBrazilian propolisextracts and their antimicrobial andantioxidant activities
  31. Brazilian propolis-derived components inhibit TNF-α-mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes

  1. Capparis Spinosa L.promotes anti-inflammatoryresponse in vitro through the control of cytokine gene expressionin human peripheral blood mononuclear cells
  2. Anti-inflammatorypotential of Capparis spinosa L.in vivo in mice through inhibition of cell infiltration and cytokine gene expression
  3. Anti-inflammatoryEffects of Caper (Capparis spinosa L.)Fruit Aqueous Extract and the Isolation of Main Phytochemicals
  4. Capparisovata treatment suppresses inflammatorycytokine expressionand ameliorates experimental allergic encephalomyelitis model of multiple sclerosis in C57BL/6 mice
  5. Evaluation of anti-bacterial activity of Capparis spinosa(Al-Kabara ) and Aloe vera extracts against Isolates Bacterial Skin Wound Infectionsin -vitro and in-vivo
  6. Isolation and identification of an anti-inflammatoryprinciple from Capparis spinosa.
  7. Biflavonoids from Caper (Capparis spinosa L.)Fruits and Their Effects in Inhibiting NF-kappa B Activation
  8. Effect of flavonoids rich extract of Capparis spinosaoninflammatoryinvolved genes in amyloid-beta peptide injected rat model of Alzheimer’s disease
  9. Investigation for anti-inflammatoryand anti-thrombotic activities of methanol extract of Capparisovata buds and fruits
  10. Capparis spinosaprotects against oxidative stressin systemic sclerosis dermal fibroblasts
  11. In vitro antioxidant and in vivo photoprotective effectsof a lyophilized extract of Capparis spinosa L. buds
  12. Physiochemical and antioxidant responsesof the perennial xerophyte Capparisovata Desf. to drought
  13. Phenolic Compounds and Vitamin Antioxidantsof Caper (Capparis spinosa)
  14. Effect of Tunisian Capparis spinosa L. extract on melanogenesis in B16 murine melanoma cells
  15. ROLES OF DURATION AND CONCENTRATION OF PRIMING AGENTSON DORMANCY BREAKING AND GERMINATION OF CAPER (CAPPARIS SPINOSA L.) FOR THE PROTECTION OF ARID DEGRADED AREAS
  16. Biflavonoids from Caper (Capparis spinosa L.) Fruits and Their Effects in Inhibiting NF-kappa B Activation

  1. CarnosolModulates Th17 CellDifferentiation and Microglial Switch in Experimental Autoimmune Encephalomyelitis
  2. Inhibitory effect of Carnosolon UVB-induced inflammationvia inhibition of STAT3
  3. Inhibitory Effect of Carnosolon Phthalic Anhydride-Induced Atopic Dermatitisvia Inhibition of STAT3
  4. CarnosolInhibits Pro-Inflammatoryand Catabolic Mediators of Cartilage Breakdown in Human Osteoarthritic Chondrocytes and Mediates Cross-Talk between Subchondral Bone Osteoblasts and Chondrocytes
  5. Anti‐inflammatoryactivity of rosemary extracts obtained by supercritical carbon dioxide enriched in carnosic acid and carnosol
  6. Carnosolprotects against renal ischemia-reperfusioninjury in rats
  7. Carnosol: A promising anti-cancer and anti-inflammatoryagent
  8. Inhibition by rosemary and carnosolof 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesisand in vivo DMBA-DNA adduct formation
  9. Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthasethrough down-regulating nuclear factor-κB in mouse macrophages
  10. The Mechanisms of Carnosolin Chemoprevention of Ultraviolet B-Light-Induced Non-Melanoma Skin Cancer Formation
  11. Syk/Src Pathway-Targeted Inhibition of Skin InflammatoryResponses by CarnosicAcid
  12. Carnosoland Related Substances Modulate Chemokine and Cytokine Productionin Macrophages and Chondrocytes
  13. Carnosolinhibits cell adhesion molecules and chemokine expressionby tumor necrosis factor-α in human umbilical vein endothelial cells through the nuclear factor-κB and mitogen-activated protein kinase pathways
  14. Carnosicacid reduces cytokine-inducedadhesion molecules expression and monocyte adhesion to endothelial cells
  15. In vitro and in vivo anti-inflammatoryeffectsof rosmanol and carnosolisolated from rosemary
  16. Carnosolpromotes endothelial differentiation under H2O2-induced oxidative stress
  17. Anti‐inflammatoryand analgesic activity of carnosoland carnosic acid in vivo and in vitro and in silico analysis of their target interactions
  18. The Role of Nitric OxideSynthase and Carnosolin UVB-induced NF-κB Activity and Skin Damage
  19. Protective effects of carnosolagainst oxidative stressinduced brain damage by chronic stress in rats
  20. Upregulation of NF-E2-related factor-2-dependent glutathione by carnosolprovokes a cytoprotective responseand enhances cell survival

  1. Phenolic acid content and free radical-scavenging activityof two differently processed carob tree (Ceratonia siliqua L.) pod
  2. Structure and Development of Stomata on the Primary Root of Ceratonia siliqua L.
  3. Reduction of hairgrowth
  4. Protective effects of polyphenol-rich infusions from carob (Ceratonia siliqua)leaves and cladodes of Opuntia ficus-indica against inflammationassociated with diet-induced obesity and DSS-induced colitis in Swiss mice
  5. Screening of indigenous Palestinian medicinal plants for potential anti-inflammatoryand cytotoxic activity
  6. Extract from Ceratonia siliquaExhibits Depigmentation Properties
  7. Anti-inflammatoryand antioxidant effectof Ceratonia siliqua L. methanol barks extract
  8. Carob pods (Ceratonia siliqua L.)inhibit human neutrophils myeloperoxidase and in vitro ROS-scavenging activity
  9. Gastroprotective effect of carob (Ceratonia siliqua L.)against ethanol-induced oxidative stressin rat
  10. The Study of Antibacterial Activity of Plantago Major and Ceratonia Siliqua
  11. Anti-InflammatoryActivity of Natural Products
  12. Protective Effect of Ceratonia siliqua L.Against a Dextran Sulfate Sodium-Induced Alterations in Liver and Kidney in Rat
  13. In vitro antioxidant and inhibitory activityof water decoctions of carob tree (Ceratonia siliqua L.)on cholinesterases, α-amylase and α-glucosidase
  14. Effects of extraction conditions on the recovery of phenolic compounds and in vitro antioxidant activityof carob (Ceratonia siliqua L.) pulp
  15. Characterization of bioactive compounds and ameliorative effects of Ceratonia siliqua leaf extract against CCl4 induced hepatic oxidative damageand renal failure in rats
  16. Ceratonia siliquahoneys from Morocco: Physicochemical properties, mineral contents, and antioxidant activities
  17. Ceratonia siliqua L.(immature carob bean) inhibits intestinal glucose absorption, improves glucose tolerance and protects against alloxan‐induced diabetes in rat
  18. Effects of aqueous extracts from Ceratonia siliqua L. podson small intestinal motility in rats and jejunal permeability in mice
  19. Ceratonia siliqua pod extract ameliorates Schistosomamansoni-induced liver fibrosis and oxidative stress
  20. Bioactive metabolites involved in the antioxidant, anticancer and anticalpain activities of Ficus carica L., Ceratonia siliqua L.and Quercus ilex L. extracts

  1. In vivo hairgrowth-stimulating effectof medicinal plant extract on BALB/c nude mice
  2. Chrysanthemum zawadskii extractinduces hair growthby stimulating the proliferation and differentiation of hairmatrix
  3. Phylogenetic analysis of Korean native Chrysanthemum speciesbased on morphological characteristics
  4. Medicinal Plants for the Treatment of HairLossand the Suggested Mechanisms
  5. Hairgrowthpromoting effectand action mechanism of Chrysanthemum zawadskii extract
  6. Hairrestorer compositionusing oriental herbs
  7. Inhibitory Effects of Chromatographically Fractionated Extracts from Chrysanthemum zawadskii on Tyrosinase Activity and Melanogenesis
  8. The Functional Effects for the Prevention and Treatment on HairLossfrom Astringent Persimmon Fruit Extracts
  9. Growthand Morphological Characteristics of Wild Clones of Chrysanthemumboreale Mak
  10. Biological activities of the herb of Chrysanthemum zawadskii
  11. Inhibitors of Nitric Oxide in Raw 264.7 Macrophages treated with Linarin： The main compound of Chrysanthemum zawadskii
  12. Chrysanthemum zawadskii extractactivates peroxisome proliferator-activated receptor-α and has an anti-inflammatoryactivity: Potential interest for the skin barrier function
  13. Immuno-Modulatory Activities of Polysaccharides separated from Chrysanthemum zawadskiivar. latilobum in Macrophage Cells
  14. Effect of Chrysanthemum zawadskiiand Menthaarvensis on skin barrier functionvia keratinocytes differentiation
  15. Abstract 5666: Nrf2-mediated induction of phase 2 detoxifying enzymes by an active compound isolated from Chrysanthemum zawadskii
  16. Chrysanthemum zawadskiivar. latilobum extract inhibits the production of nitric oxide and PGE2 through inducible nitric oxide synthase (iNOS) and cyclooxygenase-2(COX-2) in RAW 264. 7 cells
  17. Anti-inflammatory/Anti-oxidative StressActivitiesand Differential Regulation of Nrf2-Mediated Genes by Non-Polar Fractions of Tea Chrysanthemum zawadskiiand Licorice Glycyrrhiza uralensis
  18. Anti-inflammatory activity of Chrysanthemum zawadskiivar. latilobum leaf extract through haem oxygenase-1 induction
  19. 6-Methoxyluteolin from Chrysanthemum zawadskii var.latilobum SuppressesHistamine Release and Calcium Influx via Down-Regulation of FcεRI αChain Expression
  20. Anti-inflammatoryeffectsof flavonoids in Korean Chrysanthemum speciesvia suppression of inducible nitric oxide synthase and cyclooxygenase-2 in LPS-induced RAW 264.7 macrophages
  21. Suppressive Effects of Chrysanthemum zawadskii var.latilobum Flower Extracts on Nitric Oxide Productionand Inducible Nitric Oxide Synthase Expression
  22. Inhibitory Effects of 150 Plant Extracts on Elastase Activity, and Their Anti‐inflammatory Effects
  23. Isolation and identification of flavonoids from Gujeolcho (Chrysanthemum zawadskiivar. latilobum) as inhibitor of histamine release
  24. A Study on Anti-oxidative, Anti-inflammatory,and Melanin Inhibitory Effects of Chrysanthemum Sibiricum Extract
  25. Articles : Analysis of Composition and Activity of Essential Oil from Chrysanthemum zawadskiivar. Latilobum and C. indicum against Antibiotic-Resistant Pathogenic Bacteria
  26. Linarin down-regulates phagocytosis, pro-inflammatory cytokine production, and activation marker expression in RAW264.7 macrophages
  27. The Extract of Chrysanthemum zawadskiivar. latilobum Ameliorates Collagen-Induced Arthritis in Mice
  28. Chrysanthemum zawadskiiextract protects osteoblastic cells from highly reducing sugar-induced oxidative damage
  29. Identification of secondary metabolites with antioxidant and antimicrobial activitiesfrom Artemisia iwayomogi and Chrysanthemum zawadskii
  30. Extracts of Chrysanthemum zawadskiiattenuate oxidative damage to vascular endothelial cells caused by a highly reducing sugar
  31. Chrysanthemum zawadskii var. latilobum Extracts Inhibits of TPA-induced Invasion by Reducing MMP-9 Expression Via the Suppression of NF-κB
    Activation in MCF-7 Human Breast Carcinoma Cells

The Effects of Cordycepinon Ovalbumin-Induced Allergic Inflammationby Strengthening Treg Response and Suppressing Th17 Responsesin Ovalbumin-Sensitized Mice

  1. Cordycepinand a preparation from Cordyceps militaris inhibit malignant transformation and proliferation by decreasing EGFR and IL-17RA signalingin a murine oral cancer model
  2. Cordycepin InhibitsDifferentiation of Th17 Cellsand Promotes Generation of CD4+ CD25+ FoxP3+ Tregs In Vitro : 1100
  3. Cordycepininduces apoptosis in SGC‑7901 cells through mitochondrial extrinsic phosphorylation of PI3K/Akt by generating ROS
  4. Cordycepssinensis may inhibit Th22 cellchemotaxis to improve kidney function in lgA nephropathy
  5. Effect of Cordycepinon the Expression of the InflammatoryCytokinesTNF-alpha, IL-6, and IL-17A in C57BL/6 Mice
  6. Cordycepininhibits IL-1β-inducedMMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts
  7. Cordycepinprevented IL-β-induced expressionof inflammatorymediators in human osteoarthritis chondrocytes
  8. Nucleotides. Part IL.† Synthesisand Characterization of Cordycepin‐Trimer‐Vitamin and ‐Lipid Conjugates Potential Inhibitors of HIV‐1 Replication
  9. Effect of CordycepinPurified from Cordyceps militaris on Th1 and Th2Cytokinesin Mouse Splenocytes
  10. CordycepinSuppresses Expression of Diabetes Regulating Genes by Inhibition of Lipopolysaccharide-induced Inflammationin Macrophages
  11. A Phytochemically Characterized Extract of Cordycepsmilitaris and Cordycepin Protect Hippocampal Neuronsfrom Ischemic Injury in Gerbils
  12. Role of Cordycepinand Adenosine on the Phenotypic Switch of Macrophages via Induced Anti-inflammatory Cytokines
  13. Cordycepinmodulates inflammatoryand catabolic gene expression in interleukin-1beta-induced human chondrocytesfrom advanced-stage osteoarthritis: an in vitro study
  14. Cordycepin-enriched Cordyceps militaris induces immunomodulation and tumor growthdelay in mouse-derived breast cancer
  15. Regulation of human cytokines by Cordyceps militaris
  16. Osteoarthritis, an inflammatorydisease: Potential implication for the selection of new therapeutic targets
  17. Cordycepininhibits LPS-induced acute lung injury by inhibiting inflammationand oxidative stress
  18. Effect of Long-term Administration of Cordycepinfrom Cordyceps militaris on Testicular Function in Middle-aged Rats
  19. Cordycepinalleviates airway hyperreactivity in a murine model of asthma by attenuating the inflammatoryprocess
  20. Anti-hepatocarcinoma effect of cordycepinagainst NDEA-induced hepatocellular carcinomas via the PI3K/Akt/mTORand Nrf2/HO-1/NF-κB pathway in mice
  21. Cordycepindiminishes thymic stromal lymphopoietin-induced interleukin-13 production
  22. CordycepinSuppresses Thymic Stromal Lymphopoietin Expression via Blocking Caspase-1and Receptor-Interacting Protein 2 Signaling Pathways in Mast Cells
  23. Cordycepinalleviates lipopolysaccharide-induced acute lung injury via Nrf2/HO-1 pathway
  24. Protective effects of cordycepinon the histopathological changes and oxidative stressinduced by hepatic ischemia/reperfusion in rats
  25. Cordycepininhibits LPS-induced inflammatoryresponsesby modulating NOD-Like Receptor Protein 3 inflammasome activation
  26. Cordycepin(3′-deoxyadenosine) attenuates age-related oxidative stressand ameliorates antioxidant capacity in rats
  27. The neuroprotective effectsof cordycepininhibit glutamate-induced oxidative and ER stress-associated apoptosis in hippocampal HT22 cells
  28. Cordycepinprevents oxidative stress-induced inhibition of osteogenesis
  29. Polysaccharides from Cordyceps sinensismycelium ameliorate exhaustive swimming exercise-induced oxidative stress
  30. Cordycepin suppresses TNF-α-induced NF-κB activation by reducing p65 transcriptional activity, inhibiting IκBα phosphorylation, and blocking IKKγ ubiquitination
  31. Cordycepin as a sensitizer to tumour necrosis factor (TNF)‐α‐induced apoptosis through eukaryotic translation initiation factor 2α (eIF2α)‐ and mammalian target of rapamycin complex 1 (mTORC1)‐mediated inhibition of nuclear factor (NF)‐κB
  32. Cordycepin protected against the TNF-α-induced inhibition of osteogenic differentiation of human adipose-derived mesenchymal stem cells
  33. Cordycepin inhibits vascular adhesion molecule expression in TNF‑α‑stimulated vascular muscle cells
  34. Cordycepin as a sensitizer to tumour necrosis factor (TNF)-α-induced apoptosis through eukaryotic translation initiation factor 2α (eIF2α)-and mammalian target of rapamycin complex 1 (mTORC1)-mediated inhibition of nuclear factor (NF)-κB

  1. Inhibition of interleukin‐17‐stimulated interleukin‐6 and ‐8 productionby cranberrycomponents in human gingival fibroblasts and epithelial cells
  2. Effects of cranberry componentson IL-1β-stimulated production of IL-6, IL-8and VEGF by human TMJ synovial fibroblasts
  3. Anti-Porphyromonas gingivalis and Anti-InflammatoryActivitiesof A-Type CranberryProanthocyanidins
  4. CranberryProanthocyanidins Improve Intestinal sIgA During Elemental Enteral Nutrition
  5. Cranberrycomponents inhibit interleukin‐6, interleukin‐8, and prostaglandin E2 production by lipopolysaccharide‐activated gingival fibroblasts
  6. Effect of glycated albumin and cranberrycomponents on interleukin‐6and matrix metalloproteinase‐3 production by human gingival fibroblasts
  7. Cranberryextract suppresses interleukin-8 secretionfrom stomach cells stimulated by Helicobacter pylori in every clinically separated strain but inhibits growthin part of the strains
  8. Inhibition of interleukin 1β–stimulated interleukin‐6 productionby cranberrycomponents in human gingival epithelial cells: effects on nuclear factor κB and activator protein 1 activation pathways
  9. Comparison of Urinary Cytokinesafter Ingestion of CranberryJuice Cocktail in Pregnant Subjects: A Pilot Study
  10. Anti-inflammatoryActivityof a High-molecular-weight CranberryFraction on Macrophages Stimulated by Lipopolysaccharides from Periodontopathogens
  11. Effects of freeze-dried cranberrypowder on serum lipids and inflammatorymarkersin lipopolysaccharide treated rats fed an atherogenic diet
  12. Effects of cranberryextracts and ursolic acid derivatives on P-fimbriated Escherichia coli, COX-2 activity, pro-inflammatory cytokine releaseand the NF-κβ transcriptional response in vitro
  13. Green tea polyphenol epigallocatechin-3-gallate and cranberryproanthocyanidins act in synergy with cathelicidin (LL-37)to reduce the LPS-induced inflammatoryresponse in a three-dimensional co-culture model of gingival epithelial cells and fibroblasts
  14. Effects of ginger and cranberryextracts on the physiological response to exercise and markers of inflammationin horses
  15. Prevention of oxidative stress, inflammationand mitochondrial dysfunction in the intestine by different cranberryphenolic fractions
  16. Diets enriched with cranberrybeans alter the microbiota and mitigate colitis severity and associated inflammation
  17. Anti-inflammatoryeffects of cranberry juicein lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophage cells.
  18. Cranberryextract attenuates hepatic inflammationin high-fat-fed obese mice
  19. Effects of cranberry(Vaccinum macrocarpon) supplementation on iron status and inflammatorymarkersin rowers
  20. Cytoprotective effectof Proanthocyanidin‐rich cranberryfraction against bacterial cell wall‐mediated toxicity in macrophages and epithelial cells
  21. CranberryExtract Modulate InflammationIn Irradiated Rats.
  22. Chapter 81 – CranberryPolyphenols: Effects on Cardiovascular Risk Factors
  23. Preventive effect of a pectic polysaccharideof the common cranberryVaccinium oxycoccos L. on acetic acid-induced colitis in mice
  24. Cranberryextract inhibits low density lipoprotein oxidation
  25. Reduced-energy cranberryjuice increases folic acid and adiponectin and reduces homocysteine and oxidative stressin patients with the metabolic syndrome
  26. Low-energy cranberry juicedecreases lipid oxidationand increases plasma antioxidant capacity in women with metabolic syndrome
  27. A polyphenol-rich cranberryextract protects from diet-induced obesity, insulin resistance and intestinal inflammationin association with increased Akkermansia spp. population in the gut microbiota of mice
  28. Biological Activity of CranberryProanthocyanidins: Effects on Oxidation, Microbial Adhesion, Inflammation, and Health
  29. Effects of cranberrypowder on serum lipid profiles and biomarkers of oxidative stressin rats fed an atherogenic diet
  30. Effects of cranberrypowder on biomarkers of oxidative stressand glucose control in db/db mice
  31. CRANBERRY POLYPHENOLS DOWN-REGULATE THE TOLL-LIKE RECEPTOR 4 PATHWAY AND NUCLEAR FACTOR-KAPPA B ACTIVATION, WHILE STILL ENHANCING TUMOR NECROSIS FACTOR ΑLPHA SECRETION IN HL-60 CELLS

  1. Curcumin, an antioxidantand anti-inflammatoryagent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress
  2. Curcumin, inflammation, ageing and age-related diseases
  3. Curcumin, Inflammation, and Chronic Diseases: How Are They Linked?
  4. Evaluation of anti-inflammatorypropertyof curcumin(diferuloyl methane) in patients with postoperative inflammation.
  5. Effects of curcuminon retinal oxidative stress and inflammationin diabetes
  6. Enhancing anti-inflammationactivity of curcuminthrough O/W nanoemulsions
  7. Dietary CurcuminSignificantly Improves Obesity-Associated Inflammationand Diabetes in Mouse Models of Diabesity
  8. Curcuminattenuates allergic airway inflammationby regulation of CD4+CD25+ regulatory T cells (Tregs)/Th17 balancein ovalbumin-sensitized mice
  9. CurcuminAttenuates Acute Graft-versus-Host Disease Severity via In Vivo Regulations on Th1, Th17and Regulatory T Cells
  10. Treatment of low doses curcumincould modulate Th17/Tregbalance specifically on CD4+ T cell cultures of systemic lupus erythematosus patients
  11. Curcumininhibiting Th17cell differentiation by regulating the metabotropic glutamate receptor-4 expression on dendritic cells
  12. Amelioration of experimental autoimmune encephalomyelitis by curcumintreatment through inhibition of IL-17production
  13. Curcuminprotects against acute liver damage in the rat by inhibiting NF-κB, proinflammatory cytokines production and oxidative stress
  14. Curcumindownregulates the inflammatorycytokinesCXCL1 and -2 in breast cancer cells via NFκB
  15. Curcuminameliorates macrophage infiltration by inhibiting NF-κB activation and proinflammatory cytokinesin streptozotocin induced-diabetic nephropathy
  16. Curcumininhibits prostate cancer metastasis in vivo by targeting the inflammatorycytokinesCXCL1 and -2
  17. Inhibition of NFκB Activation with CurcuminAttenuates Plasma InflammatoryCytokinesSurge and Cardiomyocytic Apoptosis Following Cardiac Ischemia/Reperfusion1
  18. Investigation of the Effects of Curcuminon Serum Cytokinesin Obese Individuals: A Randomized Controlled Trial
  19. Curcuminattenuates the release of pro‐inflammatory cytokinesin lipopolysaccharide‐stimulated BV2 microglia
  20. Differential Regulation of Cytokinesand Transcription Factors in Liver by CurcuminFollowing Hemorrhage/Resuscitation
  21. Amelioration of experimental autoimmune encephalomyelitis by curcumintreatment through inhibition of IL-17production
  22. [Effect of curcuminon IL-17-induced nitric oxide production and expression of iNOS in human keratinocytes].
  23. Imiquimod-induced psoriasis-like inflammationin differentiated Human keratinocytes: Its evaluation using curcumin
  24. Inhibition of interleukin 17production by curcuminin mice with collagen-induced arthritis
  25. Curcuminameliorates arterial dysfunction and oxidative stresswith aging
  26. Curcumin Extends Life Span, Improves Health Span, and Modulates the Expression of Age-Associated Aging Genes in Drosophila melanogaster
  27. Curcumin and aging
  28. Dietary CurcuminAmeliorates Aging-RelatedCerebrovascular Dysfunction through the AMPK/Uncoupling Protein 2 Pathway
  29. Curcumininduces heme oxygenase‐1 in normal human skin fibroblasts through redox signaling: Relevance for anti‐aging intervention
  30. Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging,cancer development, cancer stem cells and microRNAs
  31. Curcumin attenuates the expression of IL-1β, IL-6, and TNF-α as well as cyclin E in TNF-α-treated HaCaT cells; NF-κB and MAPKs as potential upstream targets
  32. Curcumin Attenuates Inflammatory Responses of TNF-α-Stimulated Human Endothelial Cells
  33. Curcumin Supplementation Lowers TNF-α, IL-6, IL-8, and MCP-1 Secretion in High Glucose-Treated Cultured Monocytes and Blood Levels of TNF-α, IL-6, MCP-1, Glucose, and Glycosylated Hemoglobin in Diabetic Rats
  34. The antihyperglycemic effect of curcumin in high fat diet fed rats. Role of TNF-α and free fatty acids
  35. Curcumin Attenuates Diabetic Neuropathic Pain by Downregulating TNF-α in a Rat Model
  36. Effects of TNF-α and curcumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells
  37. Curcumin ameliorates rabbits’s steatohepatitis via respiratory chain, oxidative stress, and TNF-α
  38. Aminoguanidine and curcumin attenuated tumor necrosis factor (TNF)-α-induced oxidative stress, colitis and hepatotoxicity in mice
  39. Curcumin Attenuates TNF‐α‐induced Expression of Intercellular Adhesion Molecule‐1, Vascular Cell Adhesion Molecule‐1 and Proinflammatory Cytokines in Human Endometriotic Stromal Cells
  40. Anti-inflammatory potential of curcumin and quercetin in rats: Role of oxidative stress, heme oxygenase-1 and TNF-α
  41. Curcumin Blocks Interleukin-1 (IL-1) Signaling by Inhibiting the Recruitment of the IL-1 Receptor–Associated Kinase IRAK in Murine Thymoma EL-4 Cells
  42. Curcumin attenuates carcinogenesis by down regulating proinflammatory cytokine interleukin-1 (IL-1α and IL-1β) via modulation of AP-1 and NF-IL6 in lymphoma bearing mice
  43. Curcumin alleviates IL‐17A‐mediated p53‐PAI‐1 expression in bleomycin‐induced alveolar basal epithelial cells
  44. Curcumin attenuates IL-1β-induced endothelial lipase expression via blocking NF-κB pathway
  45. Curcumin Attenuates Expression of Adhesion Molecules by IL-1 β in HUVECs
  46. Inhibition of curcumin on the expression of IL-1 β-induced nuclear factor-κB-dependent inflammatory gene in rabbit RPE cells
  47. Curcumin (Diferuloylmethane) Inhibits Constitutive and IL-6-Inducible STAT3 Phosphorylation in Human Multiple Myeloma Cells
  48. Curcumin Inhibits Imiquimod-Induced Psoriasis-Like Inflammation by Inhibiting IL-1beta and IL-6Production in Mice
  49. Curcumin, a Potential Inhibitor of Up-regulation of TNF-alpha and IL-6Induced by Palmitate in 3T3-L1 Adipocytes through NF-kappaB and JNK Pathway
  50. Anti-ulcer Activity of Curcumin on Experimental Gastric Ulcer in Rats and Its Effect on Oxidative Stress/Antioxidant, IL-6and Enzyme Activities
  51. Effect of curcumin on acidic pH-induced expression of IL-6and IL-8 in human esophageal epithelial cells (HET-1A): role of PKC, MAPKs, and NF-κB
  52. Curcumin Attenuates CFA Induced Thermal Hyperalgesia by Modulation of Antioxidant Enzymes and Down Regulation of TNF-α, IL-1β and IL-6
  53. [Reducing effect of curcumin on expressions of TNF-alpha, IL-6and IL-8 in rats with chronic nonbacterial prostatitis].
  54. Inhibition of IL-6Signaling Pathway by Curcumin in Uterine Decidual Cells
  55. TNF-α, IL-6and IL-10 expressions, responsible for disparity in action of curcumin against cisplatin-induced nephrotoxicity in rats
  56. The Effect of Curcumin on TNF-α, IL-6and CRP Expression in a Model of Polycystic Ovary Syndrome as an Inflammation State
  57. The functional protective effect and the mechanism of curcumin on IL-6induced neuronal damage in rat hippocampus
  58. The polyphenols curcumin and resveratrol effectively block IL-1β and PMA-induced IL-6, IL-8 and VEGF-A expression in human rheumatoid synovial fibroblasts
  59. Effects of Curcumin on NF-κB、TNF-α and IL-6in ALI/ARDS Rats Induced by Oleinic Acid
  60. Curcumin Suppression of IL-6and IL-8 in Head & Neck Cancer: R115
  61. Curcumin, both Histone Deacetylase and p300/CBP‐Specific Inhibitor, Represses the Activity of Nuclear Factor Kappa B and Notch 1 in Raji Cells
  62. Protective effect of curcumin in cisplatin-induced oxidative injury in rat testis: mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways
  63. Curcumin inhibits metastatic progression of breast cancer cell through suppression of urokinase-type plasminogen activator by NF-kappa B signaling pathways
  64. Curcumin Inhibits Cell Migration of Human Colon Cancer Colo 205 Cells through the Inhibition of Nuclear Factor kappa B /p65 and Down-regulates Cyclooxygenase-2 and Matrix Metalloproteinase-2 Expressions
  65. Ameliorative effects of curcumin against renal injuries mediated by inducible nitric oxide synthase and nuclear factor kappa B during gentamicin-induced toxicity in Wistar rats
  66. Liposome-encapsulated curcumin suppresses neuroblastoma growth through nuclear factor-kappa B inhibition
  67. Hydrogel based oil encapsulation for controlled release of curcumin by using a ternary system of chitosan, kappa-carrageenan, and carboxymethylcellulose sodium salt
  68. Curcumin prevents shock-wave lithotripsy-induced renal injury through inhibition of nuclear factor kappa-B and inducible nitric oxide synthase activity in rats
  69. The effect of the NF-kappa B inhibitors curcumin and lactacystin on myogenic differentiation of rhabdomyosarcoma cells
  70. Curcumin attenuates IL-1β-induced endothelial lipase expression via blocking NF-κB pathway
  71. Response to “Inhibition of p300 and nuclear factor-[kappa]B by curcumin and its role in diabetic nephropathy”
  72. Curcumin inhibits mitogen stimulated lymphocyte proliferation, NF-kappa-B activation and IL-2 signaling
  73. Cerebroprotective role of Tetrahydro Curcumin in hyperhomocysteinemic ischemic mice by regulating NF-kappa B
  74. Combinatorial effect of curcumin and tumor necrosis factor-α-related apoptosis-inducing ligand (TRAIL) in induction of apoptosis via inhibition of nuclear factor kappa activity and enhancement of caspase-3 activity in chronic myeloid cells: An In-vitro study
  75. Effect of curcumin on keloid fibroblasts cycle and nuclear factor-kappa B signaling pathways

  1. The flavonoid cyanidinblocks binding of the cytokine interleukin-17A to the IL-17RA subunit to alleviate inflammationin vivo
  2. Cyanidin-3-O-β-glucoside attenuates allergic airway inflammationby modulating the IL-4Rα-STAT6 signaling pathway in a murine asthma model
  3. Anthocyanin-Rich Black Currant Extract and Cyanidin-3-O-Glucoside Have Cytoprotective and Anti-InflammatoryProperties
  4. Anti-inflammatoryeffectsof black rice, cyanidin-3-O-β-d-glycoside, and its metabolites, cyanidinand protocatechuic acid
  5. Cyanidin-3-O-β-D-Glucopyranoside Concentrated Materials from Mulberry Fruit Have a Potency to Protect Erectile Function by Minimizing Oxidative Stressin a Rat Model of Diabetic Erectile Dysfunction
  6. Cyanidin-3-O-β-glucoside inhibits LPS-induced expression ofinflammatorymediators through decreasing IκBα phosphorylation in THP-1 cells
  7. Cyanidin-3-Glucoside Suppresses Cytokine-InducedInflammatoryResponse in Human Intestinal Cells: Comparison with 5-Aminosalicylic Acid
  8. Anti-inflammatoryprotection afforded by cyanidin-3-glucoside and resveratrol in human intestinal cells via Nrf2 and PPAR-γ: Comparison with 5-aminosalicylic acid
  9. Cyanidin-3-glucoside suppresses Th2 cytokinesand GATA-3 transcription factor in EL-4 T cells
  10. Cyanidin-3-O-β-glucoside inhibits lipopolysaccharide-inducedinflammatoryresponse in mouse mastitis model
  11. Cyanidin-3-O-Glucoside Ameliorates Lipopolysaccharide-Induced Injury Both In Vivo and In Vitro Suppression of NF-κB and MAPK Pathways
  12. Cyanidin-3-glucoside inhibits UVB-induced oxidative damage and inflammationby regulating MAP kinase and NF-κB signaling pathways in SKH-1 hairless mice skin
  13. Anti-aging Effectsof Cyanidinunder a Stress-Induced Premature Senescence Cellular System
  14. Effects of Cyanidin-3-glycoside on PMA/Ionomycin-induced Th2 Cytokine Productionsin RBL-2H3 Cells
  15. Inhibition of Carrageenan-Induced Acute Inflammationin Mice by Oral Administration of Anthocyanin Mixture from Wild Mulberry and Cyanidin-3-Glucoside
  16. [Antioxidant and anti-inflammatoryeffects of cyanidinfrom cherries on rat adjuvant-induced arthritis].
  17. Cyanidin-3-glucoside attenuates angiotensin II-induced oxidative stressand inflammationin vascular endothelial cells
  18. Synergistic effect of atorvastatin and Cyanidin-3-glucoside on angiotensin II-induced inflammationin vascular smooth muscle cells
  19. Protective Effects of Cyanidin‐3‐O‐β‐glucopyranoside Against UVA‐induced Oxidative Stressin Human Keratinocytes
  20. Protection of cyanidin-3-glucoside against oxidative stressinduced by acrylamide in human MDA-MB-231 cells
  21. Dietary cyanidin3‐O‐β‐d‐glucoside increases ex vivo oxidationresistance of serum in rats
  22. Cyanidin-3-glucoside isolated from mulberry fruit protects pancreatic β-cells against oxidative stress-induced apoptosis
  23. Synergistic Effect of Cyanidinand PPAR Agonist against Nonalcoholic Steatohepatitis-Mediated Oxidative Stress-Induced Cytotoxicity through MAPK and Nrf2 Transduction Pathways
  24. Effect of cyanidin3-O-β-glucopyranoside on hepatic stellate cell proliferation and collagen synthesis induced by oxidative stress
  25. Oxidationproducts of cyanidin3‐O‐β‐d‐glucoside with a free radical initiator
  26. Neuroprotective effects of cyanidinagainst Aβ-induced oxidativeand ER stress in SK-N-SH cells
  27. Cyanidin-3-O-Glucoside Modulates the In VitroInflammatoryCrosstalk between Intestinal Epithelial and Endothelial Cells
  28. Cyanidinand Cyanidin-3-O-β-D-glucoside Suppress the InflammatoryResponsesof Obese Adipose Tissue by Inhibiting the Release of Chemokines MCP-1 and MRP-2
  29. Cyanidinand delphinidin modulate inflammationand altered redox signaling improving insulin resistance in high fat-fed mice
  30. Antioxidant and anti-inflammatoryactivities of cyanidin-3-glucoside and cyanidin-3-rutinoside in hydrogen peroxide and lipopolysaccharide treated RAW264.7 cells (830.23)
  31. Cyanidin 3-glucoside protects 3T3-L1 adipocytes against H2O2- or TNF-α-induced insulin resistance by inhibiting c-Jun NH2-terminal kinase activation
  32. Cyanidin-3-O-glucoside Protection against TNF-α-Induced Endothelial Dysfunction: Involvement of Nuclear Factor-κB Signaling
  33. Cyanidin-3-O-glucoside inhibits NF-kB signalling in intestinal epithelial cells exposed to TNF-α and exerts protective effects via Nrf2 pathway activation
  34. Inhibitory effect of polyphenol cyanidin on TNF-α-induced apoptosis through multiple signaling pathways in endothelial cells
  35. Cyanidin-3-glucoside suppresses TNF-α-induced cell proliferation through the repression of Nox activator 1 in mouse vascular smooth muscle cells: involvement of the STAT3 signaling
  36. Cyanidin-3-glucoside Inhibits TNF-α-Induced Mouse Vascular Smooth Muscle Cells Proliferation through Suppression of STAT3 Activation

  1. Pharmacology and immune modulating properties of 5-androstene-3β,7β,17β-triol,a DHEAmetabolite in the human metabolome
  2. Serum Dehydroepiandrosterone (DHEA)and DHEA Sulfate Are Negatively Correlated with Serum Interleukin-6 (IL-6), and DHEA Inhibits IL-6Secretion from Mononuclear Cells in Man in Vitro: Possible Link between Endocrinosenescence and Immunosenescence
  3. Serum levels of insulin-like growthfactor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailty
  4. Plasma concentration of interleukin 6 (IL-6), and its relationship with circulating concentration of dehydroepiandrosterone sulfate (DHEA-S)in patients with chronic idiopathic urticaria
  5. Increased serum levels of dehydroepiandrosterone (DHEA) and interleukin-6 (IL-6)in women with mild to moderate Alzheimer’s disease
  6. Dehydroepiandrosteronesuppresses interleukin 10synthesis in women with systemic lupus erythematosus
  7. Regulation of Murine Interleukin-10Production by Dehydroepiandrosterone
  8. Activation of Immune Function by Dehydroepiandrosterone (DHEA)in Age-Advanced Men
  9. Adrenal Hormone Modulation of Type 1 and Type 2 Cytokine Production by Spleen Cells: Dexamethasone and DehydroepiandrosteroneSuppress Interleukin-2, Interleukin-4,and Interferon-γ Productionin Vitro
  10. Regulation of murine lymphokine production in vivo II. Dehydroepiandrosteroneis a natural enhancer of interleukin 2synthesis by helper T cells
  11. Changes in Dehydroepiandrosterone (DHEA) and DHEA-SulfatePlasma Levels during Experimental Endotoxinemiain Healthy Volunteers
  12. Biochemical changes in the cervical tissue of rabbit induced by interleukin-8, interleukin-1βdehydroepiandrosteronesulphate and prostaglandin E2: a comparative study
  13. Effect of dehydroepiandrosteroneon lipopolysaccharide-induced interleukin-6production in DH82 cultured canine macrophage cells
  14. DHEA-Slevels in hypopituitaric patients with severe GH deficiency are strongly reduced across lifespan.Comparison with IGF-I levels before and during rhGH replacement
  15. Effects of 2-deoxyglucose and dehydroepiandrosteroneon intracellular NAD+ level, SIRT1activity and replicative lifespanof human Hs68 cells
  16. Physiological Concentrations of DHEA in Human Hair
  17. Hydroxylation of dehydroepiandrosteronein human scalp hairfolhcles
  18. Metabolic alterations of DHEAand cholesterol sulphates in the hairof patientswith acne measured by liquid chromatography–mass spectrometry
  19. Diurnal and Seasonal Cortisol, Testosterone, and DHEARhythms in Boys and Girls during Puberty
  20. Role of Dehydroepiandrosteroneand Dehydroepiandrosterone Sulfate for the Maintenance of Axillary Hairin Women
  21. CytokineDysregulation and Increased Oxidation Is Prevented by Dehydroepiandrosteronein Mice Infected with Murine Leukemia Retrovirus
  22. Dehydroepiandrosterone (DHEA)replacement decreases insulin resistance and lowers inflammatorycytokinesin aging humans
  23. Modulation of Cytokine Production by Dehydroepiandrosterone (DHEA)Plus Melatonin (MLT) Supplementation of Old Mice
  24. The endotoxin-induced increase of cytokines is followed by anincrease of cortisol relative to dehydroepiandrosterone (DHEA)inhealthy male subjects
  25. The Effects of Dehydroepiandrosterone (DHEA)on In Vitro Spleen Cell Proliferation and CytokineProduction
  26. Altered Cortisol/DHEARatio in Tuberculosis Patients and its Relationship with Abnormalities in the Mycobacterial‐driven Cytokine Productionby Peripheral Blood Mononuclear Cells
  27. Dehydroepiandrosteronemay be one of the regulators of cytokineproduction in atopic dermatitis
  28. The effects of dexamethasone and dehydroepiandrosterone (DHEA)on cytokinesand receptor expression in a human osteoblastic cell line: Potential steroid-sparing role for DHEA
  29. Preliminary studies on the effect of dehydroepiandrosterone (DHEA)on both constitutive and phytohaemagglutinin (PHA)‐inducible IL‐6 and IL‐2mRNA expression and cytokine production in human spleen mononuclear cell suspensions in vitro
  30. Role of androgens in dhea-induced rack1 expression and cytokinemodulation in monocytes
  31. Low cortisol, high DHEA, and high levels of stimulated TNF‐α, and IL‐6 in women with PTSD
  32. The influence of age and gender on serum dehydroepiandrosterone sulphate (DHEA-S), IL-6, IL-6soluble receptor (IL-6sR) and transforming growth factor beta 1 (TGF-β1) levels in normal healthy blood donors
  33. IL-6, DHEA and the ageing process
  34. Activity of Lymphocyte Subpopulations in Polymicrobial Sepsis and DHEA Treatment in IL-6Knockout Mice
  35. Low levels of cortisol and sIgA, high levels of DHEA-S, and high stimulated levels of TNF-α and IL-6in women with PTSD
  36. DHEA Can Inhibit the Proliferation of Myeloma Cells and the IL-6Production of Bone Marrow Mononuclear Cells from the Myeloma Patients.
  37. DHEA MODULATES CYTOKINE EXPRESSION VIA IL-6IN A MULTIPLE
  38. 7018 POSTER Evaluation of serum IL-6, DHEA and DHEAS levels in comparison with two conventional metastatic markers in melanoma
  39. Dehydroepiandrosterone (DHEA) inhibits IL-6secretion from monocytes and peripheral blood mononuclear cells (PBL) in man
  40. DHEA-dependent and organ-specific regulation of TNF-αmRNA expression in a murine polymicrobial sepsis and trauma model
  41. Are alterations of lymphocyte subpopulations in polymicrobial sepsis and DHEA treatment mediated by the tumour necrosis factor (TNF)‐α receptor (TNF‐RI)? A study in TNF‐RI (TNF‐RI–/–) knock‐out rodents
  42. DHEA wirkt protektiv bei einer experimentellen polymikrobiellen Sepsis durch CLP — besteht eine pathogenetische Bedeutung des TNF-α?
  43. IL-6vermittelt protektive Effekte des DHEA bei einer polymikrobiellen Sepsis

  1. In vitro antifungal activity of dragon’s bloodfrom Croton urucurana against dermatophytes
  2. Observation of the Effect of Dragon’s Bloodin Treating Moist DermatitisResulted from Radioactive Treatment of Nasopharyngeal Carcinoma
  3. Dragon’s BloodInhibits ChronicInflammatoryand Neuropathic Pain Responses by Blocking the Synthesis and Release of Substance P in Rats
  4. Effect of Resina Draconison the Repair of SkinDefect Treated with Tissue Engineering Skin
  5. Dragon’s Bloodointment promoting acute skin woundhealing in rat
  6. Effect of Sanguis draconis (a dragon’s blood resin) on streptozotocin- and cytokine-inducedβ-cell damage, in vitro and in vivo
  7. Sanguis draconis, a Dragon’s Blood Resin, Attenuates High Glucose-Induced Oxidative Stressand Endothelial Dysfunction in Human Umbilical Vein Endothelial
  8. Suppression of lipopolysaccharide-induced of inducible nitric oxide synthaseand cyclooxygenase-2 by Sanguis Draconis, a dragon’s blood resin, in RAW 264.7 cells
  9. Dragon’s bloodand its extracts attenuate radiation-induced oxidative stressin mice
  10. Immunomodulatory Activity and Chemical Characterisation of Sangre de Drago (Dragon’s Blood)from Croton lechleri
  11. Ethylacetate extract from DraconisResinainhibits LPS-inducedinflammatoryresponses in vascular smooth muscle cells and macrophages via suppression of ROS production
  12. Mutagenic and antioxidant activitiesof Croton lechleri sap in biological systems
  13. Studies on anti-inflammationand analgesic effects of dragon’s blood
  14. Anti-inflammatoryFlavan-3-ol-dihydroretrochalcones from Daemonorops draco
  15. Anti-InflammatoryAnd Analgesic Effects Of Ethanol Extract Of DracaenaCinnabari Balf, As Endemic Plant In Yemen
  16. Dragon’s BloodMay Have Radioprotective Effects in Radiation-Induced Rat Brain Injury
  17. Dragon’s blooddropping pills have protective effects on focal cerebral ischemiarats model
  18. Review of Sangre de Drago (Croton lechleri)- A South American Tree Sap in the Treatment of Diarrhea, Inflammation, Insect Bites, Viral Infections, and Wounds: Traditional Uses to Clinical Research
  19. Effects of Sangre de Drago from Croton lechleri Muell.-Arg. on the production of active oxygen radicals
  20. Inhibition of Neurogenic Inflammationby the Amazonian Herbal Medicine Sangre de Grado
  21. The Effect of ProstaglandinF_(2a) (PGF_(2a)) in the Blood Plasma and Interleukin-1?(IL-1?) in the Blood Serum of Endometriosis in the Rats Treated with Complex Prescription Dragon’s Blood Plaster

  1. Antimicrobial activity and cytotoxicity of Eclipta prostrata
  2. Anti-inflammatoryactivityof methanolic extract of Eclipta prostrata L. (Astearaceae)
  3. Ethnopharmacological uses, phytochemistry, biological activities, and biotechnological applications of Eclipta prostrata
  4. Antidermatophytic activityof Eclipta prostrataL. against human infective Trichophyton and Microsporum spp.
  5. Three new olean-type triterpenoid saponinsfrom aerial parts of Eclipta prostrata (L.)
  6. Bioactive triterpenoids, antimicrobial, antioxidant and cytotoxic activitiesof Eclipta prostrata Linn
  7. Simultaneous extraction, identification and quantification of phenolic compounds in Eclipta prostrata using microwave-assisted extraction combined with HPLC–DAD–ESI–MS/MS
  8. Potent Antioxidativeand UVB Protective Effect of Water Extract of Eclipta prostrata L.
  9. Eclipta prostrata (L.) L. (Asteraceae)–an eco-friendly natural hairdye
  10. Use of Eclipta prostrataand other PPAR-gamma inhibitors in cosmeticsand compositions thereof
  11. IN VITROEVALUATION OF TOTAL PHENOLICS AND ANTIOXIDANT ACTIVITIESOF WITHANIA SOMNIFERA, ECLIPTA PROSTRATALAND GOSSYPIUM HERBASCEUML
  12. PHYTOCHEMICAL SCREENING AND ANTIOXIDANTPOTENTIAL OF ECLIPTA PROSTRATA (L)L-A VALUABLE HERB
  13. Selected PLants used as hairtonic
  14. Effects of Herbal Extracts on HairGrowthin an Animal Model of C3H/HeJ Mice
  15. In-Vitro Study of Anthelmintic Activity of Eclipta prostrata(L) y various Extracts
  16. Clinical Trials of Eclipta Prostrata(L.)L as Hepatoprotectiveand Their Market Formulations
  17. Echinocystic Acid Isolated from Eclipta prostrataSuppresses Lipopolysaccharide-Induced iNOS, TNF-α, and IL-6Expressions via NF-κB Inactivation in RAW 264.7 Macrophages
  18. Osteoprotective Effect of Echinocystic Acid, a Triterpone Component from Eclipta prostrata,in Ovariectomy-Induced Osteoporotic Rats
  19. Ecliptamines A–D, four new guanidine alkaloids from Eclipta prostrata L.
  20. Eclipta prostrataImproves DSS-Induced Colitis through Regulation of InflammatoryResponsein Intestinal Epithelial Cells
  21. Enhancement of Skin Anti-InflammatoryActivitiesof Eclipta prostrata L. from the Ultrasonic Extraction Process
  22. Effect of Eclipta prostrataon 11Beta-Hydroxysteroid Dehydrogenase in Rat Liver and Kidney
  23. The effects of Eclipta Prostrata L.(Ecliptae Herba)on periodontitis rats
  24. Wedelolactone from Vietnamese Eclipta prostrata (L)L. Protected Zymosan-induced shock in Mice
  25. A polysaccharide from Eclipta prostrataalleviates experimental autoimmune encephalomyelitis through inhibiting Th17 cells
  26. Eclipta prostratapromotes the induction of anagen, sustains the anagen phase through regulation of FGF-7 and FGF-5
  27. Screening of antibacterial and antioxidant activitiesof leaves of Eclipta prostrata (L)
  28. Composition and method for stimulating the synthesis of the melanotic pigment of the skin
  29. Surfactant-assisted Water Extraction of Flavonoids from Eclipta Prostrata L.
  30. Primary Discussion on the Hemostatic Activityof Aqueous Extracts from the Leaves of Eclipta prostrata L.

  1. EGCGAttenuates Autoimmune Arthritis by Inhibition of STAT3 and HIF-1α with Th17/Treg Control
  2. Potential benefits of green tea polyphenol EGCGin the prevention and treatment of vascular inflammationin rheumatoid arthritis
  3. Comparative effects of polyphenols from green tea (EGCG)and soybean (genistein) on VEGF and IL-8release from normal human keratinocytes stimulated with the proinflammatory cytokineTNFα
  4. Green tea EGCGsuppresses T cell proliferation through impairment of IL-2/IL-2 receptor signaling
  5. Combined administration of EGCGand IL-1 receptor antagonist efficiently downregulates IL-1-inducedtumorigenic factors in U-2 OS human osteosarcoma cells
  6. EGCGdownregulates IL-1RI expressionand suppresses IL-1-inducedtumorigenic factors in human pancreatic adenocarcinoma cells
  7. Green tea polyphenol (−)-epigallocatechin gallateblocks epithelial barrier dysfunction provoked by IFN-γ but not by IL-4
  8. (-)-Epigallocatechin-3-gallateinhibits VEGF expression induced by IL-6via Stat3in gastric cancer
  9. ArticleEpigallocatechin-3-gallateamelioratesautoimmune arthritis by reciprocal regulationof T helper-17 regulatory T cellsand inhibitionof osteoclastogenesis by inhibitingSTAT3 signaling
  10. Green tea polyphenol epigallocatechin-3-gallateinhibits the IL-1β-inducedactivity and expression of cyclooxygenase-2 and nitric oxide synthase-2 in human chondrocytes
  11. Epigallocatechin gallate, a constituent of green tea, suppresses cytokine-induced pancreatic β-cell damage
  12. Novel chemotherapeutic and renal protective effects for the green tea (EGCG): Role of oxidative stressand inflammatory-cytokinesignaling
  13. EGCGattenuates pro-inflammatory cytokinesand chemokinesproduction in LPS-stimulated L02 hepatocyte
  14. The tea flavonoid epigallocatechin-3-gallatereduces cytokine-inducedVCAM-1 expression and monocyte adhesion to endothelial cells
  15. Effects of Varied EGCG and (+)-CatechinConcentrations on Proinflammatory CytokinesmRNA Expression in ConA-Stimulated Primary White Blood Cell Cultures
  16. Novel immunoregulatory properties of EGCGon reducing inflammationin EAE
  17. Epigallocatechin-3-gallateprotects pro-inflammatory cytokineinduced injuries in insulin-producing cells through the mitochondrial pathway
  18. Targeting of histamine producing cells by EGCG: a green dart against inflammation?
  19. Legionella pneumophila Replication in Macrophages Inhibited by Selective Immunomodulatory Effects on CytokineFormation by Epigallocatechin Gallate, a Major Form of Tea Catechins
  20. Green Tea Polyphenol Epigallocatechin-3-gallate(EGCG) Differentially Inhibits Interleukin-1β-InducedExpression of Matrix Metalloproteinase-1 and -13 in Human Chondrocytes
  21. Epigallocatechin-3-O-gallatemodulates global microRNA expression in interleukin-1β-stimulatedhuman osteoarthritis chondrocytes: potential role of EGCGon negative co-regulation of microRNA-140-3p and ADAMTS5
  22. Epigallocatechin-3-gallateinhibits angiotensin II and interleukin-6-inducedC-reactive protein production in macrophages
  23. Stimulation of human monocyte and polymorphonuclear cell iodination and interleukin‐1production by epigallocatechin gallate
  24. Epigallocatechin-3-gallateinhibits interleukin-6-and angiotensin II-induced production of C-reactive protein in vascular smooth muscle cells
  25. (−)-Epigallocatechin-3-GallatePrevents Photocarcinogenesis in Mice through Interleukin-12–Dependent DNA Repair
  26. Epigallocatechin-3-gallatesuppresses the global interleukin-1beta-induced inflammatoryresponse in human chondrocytes
  27. Regulation of interleukin‐1β–induced chemokine production and matrix metalloproteinase 2 activation by epigallocatechin‐3‐gallatein rheumatoid arthritis synovial fibroblasts
  28. Prevention of Ultraviolet Radiation–Induced Immunosuppression by (−)-Epigallocatechin-3-Gallatein Mice Is Mediated through Interleukin 12–DependentDNA Repair
  29. Epigallocatechin‐3‐gallateselectively inhibits interleukin‐1 β‐inducedactivation of mitogen activated protein kinase subgroup c‐Jun N‐terminal kinase in human osteoarthritis chondrocytes
  30. Epigallocatechin GallateAttenuates Proliferation and Oxidative Stressin Human Vascular Smooth Muscle Cells Induced by Interleukin-1
    via Heme Oxygenase-1
  31. Regulation of Prostaglandin E2 (PGE2)-induced IL-6production by Epigallocatechin-3-gallate (EGCG) in rheumatoid arthritis synovial fibroblasts
  32. Epigallocatechin-3-gallate (EGCG) inhibits IL-6-induced CRP synthesis and ameliorates adiponectin expression in Hep3B cells
  33. Chronic administration of low dose EGCG inhibits TNF-α-induced IL-6and IL-8 production in rheumatoid arthritis synovial fibroblasts
  34. Epigallocatechin-3-gallate (EGCG) inhibits IL-1β-induced IL-6production and cyclooxygenase-2 (COX-2) expression in rheumatoid arthritis synovial fibroblasts in vitro
  35. Effect of the green tea polyphenol epigallocatechin gallate (EGCG) on growth and IL-6signalling pathways in malignant plasma cells
  36. 48th Annual Meeting of the Orthopaedic Research Society Poster No: 0423 EPIGALLOCATECHIN-3-GALLATE (EGCG) INHIBITS THE INFLAMMATORY EFFECTS OF IL-1BETA IN HUMAN CHONDROCYTES.
  37. Effects of EGCG from green tea on IL-1β -induced expression of MMP-1 and MMP-13, and production of PGE2 and NO on human IVD cells in vitro
  38. New TNF-α releasing inhibitors as cancer preventive agents from traditional herbal medicine and combination cancer prevention study with EGCG and sulindac or tamoxifen
  39. EGCG stimulates the recruitment of brite adipocytes, suppresses adipogenesis and counteracts TNF-α-triggered insulin resistance in adipocytes
  40. EGCG attenuates the inhibitory effect of high TNF-α level on the process of wound healing in dermal fibroblasts
  41. The roles of caveolin-1 and heme oxygenase-1 in EGCG-mediated protection against TNF-α-induced endothelial inflammation
  42. Effects of Green Tea and EGCG on IL-8 Inflammatory Responses in LPS and TNF-α-Induced, Differentiated HT-29 Human Colon Cancer Cells
  43. INHIBITION OF TNF-α-INDUCED CASPASE-3 ACTIVITY BY EPIGALLOCATECHIN-3-GALLATE (EGCG) IN HUMAN ARTICULAR CHONDROCYTES.

  1. Protective effect of ellagic acid, a natural polyphenolic compound, in a murine model of Crohn’s disease
  2. Ellagic acidalleviates adjuvant induced arthritis by modulation of pro- and anti-inflammatorycytokines
  3. Neuroprotective effects of ellagic acidon cuprizone-induced acute demyelination through limitation of microgliosis, adjustment of CXCL12/IL-17/IL-11 axisand restriction of mature oligodendrocytes apoptosis
  4. Ellagic acidreduces murine schistosomiasis mansoni immunopathology via up-regulation of IL-10 and down-modulation of pro-inflammatory cytokines production
  5. Ellagic acidprotects against carrageenan-induced acute inflammationthrough inhibition of nuclear factor kappa B, inducible cyclooxygenase and proinflammatory cytokines and enhancement of interleukin-10via an antioxidant mechanism
  6. Anti-inflammatoryeffectsof Lafoensia pacari and ellagic acidin a murine model of asthma
  7. Anti-inflammatoryand anti-coagulatory activities of caffeic acid and ellagic acidin cardiac tissue of diabetic mice
  8. Ellagic acidinhibits oxidized LDL-mediated LOX-1 expression, ROS generation, and inflammationin human endothelial cells
  9. Dietary compound ellagic acidalleviates skin wrinkle and inflammationinduced by UV‐B irradiation
  10. Anti-InflammatoryEffectsof Ellagic Acidon Acute Lung Injury Induced by Acid in Mice
  11. The Modulatory Effect of Ellagic Acidand Rosmarinic Acid on Ultraviolet-B-Induced Cytokine/ChemokineGene Expression in Skin Keratinocyte (HaCaT) Cells
  12. Anti‐glycative and anti‐inflammatory effectsof caffeic acid and ellagic acidin kidney of diabetic mice
  13. Differential Inhibitory Effects of the Polyphenol Ellagic Acidon InflammatoryMediators NF‐κB, iNOS, COX‐2, TNF‐α, and IL‐6in 1,2‐Dimethylhydrazine‐Induced Rat Colon Carcinogenesis
  14. A study of the mechanisms underlying the anti-inflammatoryeffect of ellagic acidin carrageenan-induced paw edema in rats
  15. Ellagic acidinhibits IL-1β-inducedcell adhesion molecule expression in human umbilical vein endothelial cells
  16. Pharmacodynamics of ellagic acidon cardiac troponin-T, lyosomal enzymes and membrane bound ATPases: Mechanistic clues from biochemical, cytokineand in vitro studies
  17. Ellagic acidand polyphenolics present in walnut kernels inhibit in vitro human peripheral blood mononuclear cell proliferation and alter cytokineproduction
  18. Anti-inflammatorypotential of ellagic acid, gallic acid and punicalagin A&B isolated from Punica granatum
  19. Molecular and biochemical evidence on the protective role of ellagic acidand silybin against oxidative stress-induced cellular aging
  20. NF-κB-dependent anti-inflammatoryactivity of urolithins, gut microbiota ellagic acid-derived metabolites, in human colonic fibroblasts
  21. Inhibitory Effect of an Ellagic Acid-Rich Pomegranate Extract on Tyrosinase Activity and Ultraviolet-Induced Pigmentation
  22. Effects of Oral Administration of Ellagic Acid-Rich Pomegranate Extract on Ultraviolet-Induced Pigmentation in the Human Skin
  23. Enhancement of radiation-induced oxidative stressand cytotoxicity in tumor cells by ellagic acid
  24. Reduction of oxidative stressand apoptosis in hyperlipidemic rabbits by ellagic acid
  25. Ellagic AcidPrevents Cisplatin‐Induced Oxidative Stressin Liver and Heart Tissue of Rats
  26. Role of Ellagic Acidagainst Cisplatin‐Induced Nephrotoxicity and Oxidative Stressin Rats
  27. Ellagic acidprotects human keratinocyte (HaCaT) cells against UVA-induced oxidative stressand apoptosis through the upregulation of the HO-1 and Nrf-2 antioxidant genes
  28. Ellagic acidattenuates oxidative stresson brain and sciatic nerve and improves histopathology of brain in streptozotocin-induced diabetic rats
  29. The modulatory effects of ellagic acidand vitamin E succinate on TCDD‐induced oxidative stressin different brain regions of rats after subchronic exposure
  30. Ellagic acidameliorates isoproterenol induced oxidative stress: Evidence from electrocardiological, biochemical and histological study
  31. Therapeutic effects of ellagic acid on memory, hippocampus electrophysiology deficits, and elevated TNF-αlevel in brain due to experimental traumatic brain injury
  32. ELLAGIC ACID IMPROVED COGNITIVE DEFICIT, BRAIN ELECTROPHYSIOLOGY DECAY AND BRAIN CONTENT OF TNF-α IN RAT WITH TRAUMATIC BRAIN INJURY
  33. Ellagic acid protects against carrageenan-induced acute inflammation through inhibition of nuclear factor kappa B, inducible cyclooxygenase and proinflammatory cytokines and enhancement of interleukin-10 via an antioxidant mechanism
  34. Ellagic acid protects against LPS-induced acute lung injury through inhibition of nuclear factor kappa B, proinflammatory cytokines and enhancement of interleukin-10

  1. [Effects of emodinon IL-23/IL-17inflammatoryaxis, Th17 cellsand viral replication in mice with viral myocarditis].
  2. Emodininhibits splenocyte proliferation and inflammationby modulating cytokine responsesin a mouse model system
  3. Emodininhibited ozone stress-induced airway hyperresponsiveness by regulating epithelial protection mechanisms against injury
  4. Regulation of cell proliferation, inflammatorycytokineproduction and calcium mobilization in primary human T lymphocytes by emodinfrom Polygonum hypoleucum Ohwi
  5. Aloe-emodinprevents cytokine-inducedtumor cell death: the inhibition of auto-toxic nitric oxide releaseas a potential mechanism
  6. Aloe-emodinAffects the Levels of Cytokinesand Functions of Leukocytes from Sprague-Dawley Rats
  7. The influence of emodinand danshensu on monocyte^s secretion of inflammatorycytokines
  8. The Effects of Emodinon the Expression of Cytokinesand Functions of Leukocytes from Sprague-Dawley Rats
  9. Aloe-emodinfrom rhubarb (Rheum rhabarbarum) inhibits lipopolysaccharide-inducedinflammatoryresponses in RAW264.7 macrophages
  10. EmodinInhibits Proinflammatory Responsesand Inactivates Histone Deacetylase 1 in Hypoxic Rheumatoid Synoviocytes
  11. Emodinsuppresses inflammatoryresponsesand joint destruction in collagen-induced arthritic mice
  12. Emodininhibits LPS-inducedinflammatoryresponse by activating PPAR-γ in mouse mammary epithelial cells
  13. Anti-InflammatoryEffectof Emodinvia Attenuation of NLRP3 Inflammasome Activation
  14. Protective effect of emodinagainst airway inflammationin the ovalbumin-induced mouse model
  15. EmodinIsolated from Polygoni cuspidati Radix Inhibits TNF-αand IL-6Releaseby Blockading NF-κB and MAP Kinase Pathways in Mast Cells Stimulated with PMA Plus A23187
  16. Emodininhibits ATP-induced IL-1β secretion, ROS production and phagocytosis attenuation in rat peritoneal macrophages via antagonizing P2X7 receptor
  17. Emodinameliorates lipopolysaccharides-induced corneal inflammationin rats
  18. Chemopreventive effects of emodinand cassiamin B in mouse skincarcinogenesis
  19. The Molecular Effects of Aloe-Emodin(AE)/Liposome-AE on Human Nonmelanoma Skin Cancer Cells and Skin Permeation
  20. Ethanol and aloe emodinalter the p53 mutational spectrum in ultraviolet radiation–induced murine skintumors
  21. Aloe-emodininhibits proliferation of adult human keratinocytesin vitro
  22. Emodinsuppresses interleukin-1β inducedmesangial cells proliferation and extracellular matrix production via inhibiting P38 MAPK
  23. [Interventional effects of emodinon transforming growthfactor-beta1/integrin-linked kinase signal way in interleukin-1beta-induced transdifferentiation of rat tubular epithelial-myofibroblasts].
  24. Emodinmitigates diesel exhaust particles-induced increase in airway resistance, inflammationand oxidative stressin mice
  25. Critical role of oxidative stressand sustained JNK activation in aloe-emodin-mediated apoptotic cell death in human hepatoma cells
  26. Protective effects of emodinagainst cisplatin‐induced oxidative stressin cultured human kidney (HEK 293) cells
  27. Emodin-Provoked Oxidative StressInduces Apoptosis in Human Colon Cancer HCT116 Cells through a p53-Mitochondrial Apoptotic Pathway
  28. Emodin, an anthraquinone derivative, protects against gamma radiation-induced toxicity by inhibiting DNA damage and oxidative stress
  29. Alteration of subcellular redox equilibrium and the consequent oxidative modificationof nuclear factor κB are critical for anticancer cytotoxicity by emodin, a reactive oxygen species-producing agent
  30. EmodinPrevents Intrahepatic Fat Accumulation, Inflammationand Redox Status Imbalance During Diet-Induced Hepatosteatosis in Rats
  31. Effect of Emodin on Serum Albumin and TNF-α、IL-6of Abdominal infection Rats
  32. Effect of Emodin on TNFα,IL-6and Apoptosis of Pancreatic Acinar Cells in Severe Acute Pancreatitis in Rats
  33. Effect of emodin on secretion of TNF_?, IL-1, IL-6, and level of intracellular Ca~(2+) by rat peritoneal macrophage
  34. Original Article : Emodin Isolated from Polygoni cuspidati Radix Inhibits TNF-α and IL-6Release by Blockading NF-kB and MAP Kinase Pathways in Mast Cells Stimulated with PMA Plus A23187
  35. Emodin inhibits TNF α-induced MMP-1 expression through suppression of activator protein-1 (AP-1)
  36. Emodin inhibits TNF‐α‐induced human aortic smooth‐muscle cell proliferation via caspase‐ and mitochondrial‐dependent apoptosis
  37. Emodin attenuates TNF-α-induced apoptosis and autophagy in mouse C2C12 myoblasts though the phosphorylation of Akt
  38. Emodin induced necroptosis in the glioma cell line U251 via the TNF-α/RIP1/RIP3 pathway
  39. Research on changes of interleukin-1β and TNF- α in acute edematous pancreatitis and the intervention of emodin

  1. Antinociceptive and anti-inflammatorypropertiesof the hydroalcoholic extract of stems from Equisetum arvense L. in mice
  2. Equisetum arvense (common horsetail)modulates the function of inflammatoryimmunocompetent cells
  3. Phytochemistry and pharmacological propertiesof Equisetum arvenseL.
  4. Antioxidative and Antiproliferative Activitiesof Different Horsetail (Equisetum arvense L.) Extracts
  5. Chemical fingerprinting of Equisetum arvenseL. using HPTLC densitometry and HPLC
  6. The Effect of Equisetum Arvense(Horse Tail) Ointment on Wound Healing and Pain Intensity After Episiotomy: A Randomized Placebo-Controlled Trial
  7. Antioxidative activitiesof water extract and ethanol extract from field horsetail (tsukushi) Equisetum arvense L
  8. Urinary metabolites of flavonoidsand hydroxycinnamic acids in humans after application of a crude extract from Equisetum arvense
  9. Evaluation of the Subchronic Toxicity of Dietary Administered Equisetum arvensein F344 Rats
  10. Growthin Vitro of Excised Roots of Equisetum arvenseas Modified by Indole-3-Acetic, Indole-3-Butyric, and α-Naphthaleneacetic Acids
  11. Some Experiments on the Polarity of Spores in Dryopteris erthrosora and Equisetum arvense
  12. Occurrence of Dermatitis in Rats Fed a Cholesterol Diet Containing Field Horsetail (Equisetum arvense L.)
  13. Complete plastome sequences of Equisetum arvenseand Isoetes flaccida: implications for phylogeny and plastid genome evolution of early land plant lineages
  14. Composition for treating hairand scalpand method for preparing same
  15. Cytological and proteomic analyses of horsetail (Equisetum arvense L.)spore germination
  16. Microwave-assisted extraction for the recovery of antioxidants from waste Equisetum arvense
  17. Silica deposition and ultrastructure in the cell wall of Equisetum arvense:the importance of cell wall structures and flow control in biosilicification?
  18. Equisetum arvense L. ExtractInduces Antibacterial Activity and Modulates Oxidative Stress, Inflammation, and Apoptosis in Endothelial Vascular Cells Exposed to Hyperosmotic Stress
  19. The Effects of Fermented Equisetum arvenseon Moisturizing Capabilities in HaCaT Keratinocytes
  20. Physiological Activities of Extracts from Vegetative Stems of Equisetum arvense
  21. In Vitro Anti-inflammatoryEffects of Equisetum arvenseAre Not Solely Mediated by Silica
  22. Composition and antimicrobial activity of Equisetum arvense L. essential oil
  23. Equisetum arvensehydromethanolic extracts in bone tissue regeneration: in vitro osteoblastic modulation and antibacterial activity
  24. Analysis of Phenolic Compounds Composition by HPLC andAssessment of Antioxidant Capacity in Equisetum arvense L. Extracts
  25. Evaluation of the efficacy of dietary supplements based on Equisetum arvense, Soy Isoflavones, Lactoferrin and vitamin D3 on the control of climacteric symptoms
  26. Radical scavengingand antimicrobial activity of horsetail (Equisetum arvense L.) extracts
  27. Consecutive Production of Hydroalcoholic Extracts, Carbohydrates Derivatives and Silica Nanoparticles from Equisetum arvense
  28. Three 2-oxoglutarate-dependent dioxygenase activities of Equisetum arvense L. forming flavone and flavonol from (2S)-naringenin
  29. The Saccharomyces cerevisiae transcriptome as a mirror of phytochemical variation in complex extracts of Equisetum arvensefrom America, China, Europe and India
  30. Study of acute hepatotoxicity of Equisetum arvense L. in rats
  31. Assessing the role of the transcription factor nuclear factor kappa B (NF-kB) in the anti-inflammatory activity of EQUISETUM ARVENSE (COMMON HORSETAIL) extracts

  1. Ferulic AcidInduces Th1 Responsesby Modulating the Function of Dendritic Cells and Ameliorates Th2-Mediated Allergic Airway Inflammationin Mice
  2. Ferulic acidsupresses Th2 immune responseand prevents remodeling in ovalbumin-induced pulmonary allergy associated with inhibition of epithelial-derived cytokines
  3. Ferulic acidinhibits interleukin 17‐dependentexpression of nodal pathogenic mediators in fibroblast‐like synoviocytes of rheumatoid arthritis
  4. Ferulic AcidStabilizes a Solution of Vitamins C and E and Doubles its Photoprotection of Skin
  5. FA15, a hydrophobic derivative of ferulic acid, suppressesinflammatoryresponses and skin tumorpromotion: comparison with ferulic acid
  6. A topical antioxidant solution containing vitamins C and E stabilized by ferulic acidprovides protection for human skin against damagecaused by ultraviolet irradiation
  7. Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet‐induced photodamage in human skin
  8. Protective effect of ferulic acidon 7,12-dimethylbenz[a]anthracene-induced skin carcinogenesisin Swiss albino mice
  9. Ferulic acid, a phenolic phytochemical, inhibits UVB-induced matrix metalloproteinases in mouse skinvia posttranslational mechanisms
  10. A comparison of skin deliveryof ferulic acidand its derivatives: Evaluation of their efficacy and safety
  11. Skin Deliveryof Ferulic Acidfrom Different Vesicular Systems
  12. Inhibitory effect of topical application of polymerized ferulic acid, a synthetic lignin, on tumor promotion in mouse skin two-stage tumorigenesis
  13. Inhibitory Effect of Ferulic Acidand Isoferulic Acid on Murine Interleukin-8 Productionin Response to Influenza Virus Infections in vitro and in vivo
  14. INHIBITORY EFFECT OF FERULIC ACIDON MACROPHAGEINFLAMMATORYPROTEIN-2 PRODUCTION IN A MURINE MACROPHAGE CELL LINE, RAW264.7
  15. Ferulic acidinhibits neuro-inflammationin mice exposed to chronic unpredictable mild stress
  16. Attenuation of chronic neuroinflammation by a nitric oxide‐releasingderivative of the antioxidant ferulic acid
  17. Promising role of ferulic acid, atorvastatin and their combination in ameliorating high fat diet-induced stressin mice
  18. Iron-induced oxidative damageand apoptosis in cerebellar granule cells: attenuation by tetramethylpyrazine and ferulic acid
  19. In vivo protective effects of ferulic acidethyl ester against amyloid‐beta peptide 1–42‐induced oxidative stress
  20. In vivo protection of synaptosomes by ferulic acidethyl ester (FAEE) from oxidative stressmediated by 2,2-azobis(2-amidino-propane)dihydrochloride (AAPH) or Fe2+/H2O2: Insight into mechanisms of neuroprotection and relevance to oxidative stress-related neurodegenerative disorders
  21. Ferulic acidinhibits oxidative stressand cell death induced by Ab oligomers: Improved delivery by solid lipid nanoparticles
  22. In vitro and in vivo antioxidant properties of ferulic acid: A comparative study with other natural oxidation inhibitors
  23. Ferulic acidinhibits UV-B–induced oxidative stressin human lymphocytes
  24. Influence of ferulic acidon γ-radiation induced DNA damage, lipid peroxidation and antioxidant statusin primary culture of isolated rat hepatocytes
  25. Ferulic AcidProtects Human Umbilical Vein Endothelial Cells from Radiation Induced Oxidative Stressby Phosphatidylinositol 3-Kinase and Extracellular Signal-Regulated Kinase Pathways
  26. Treatment with ferulic acidto rats with streptozotocin-induced diabetes: effects on oxidative stress, pro-inflammatory cytokines, and apoptosis in the pancreatic β cell
  27. Redox regulation of cellular stress response by ferulic acidethyl ester in human dermal fibroblasts: role of vitagenes
  28. Protective effect of ferulic acidethyl ester against oxidative stressmediated by UVB irradiation in human epidermal melanocytes
  29. Ferulic acidprotects lymphocytes from radiation-predisposed oxidative stressthrough extracellular regulated kinase
  30. Ferulic Acid: a Natural Antioxidant Against Oxidative StressInduced by Oligomeric A-beta on Sea Urchin Embryo
  31. Aqueous Extract of Tomato (Solanum lycopersicum L.) and Ferulic Acid Reduce the Expression of TNF-α and IL-1β in LPS-Activated Macrophages
  32. The molecular events behind ferulic acid mediated modulation of IL-6expression in LPS-activated Raw 264.7 cells
  33. Ferulic acid ameliorates radiation induced duodenal inflammation by modulating nuclear factor Kappa beta-nuclear factor-2 erythroid related factor-2 cross talk

  1. A Marine Carotenoid, Fucoxanthin, Induces Regulatory T Cells and Inhibits Th17 CellDifferentiation in Vitro
  2. Comparative effect of fucoxanthinand vitamin C on oxidativeand functional parameters of human lymphocytes
  3. The Suppressive Effect of a Marine Carotenoid, Fucoxanthin, on Mouse Ear Swelling through Regulation of Activities and mRNA Expression of Inflammation-associated Enzymes
  4. Protective Effect of Fucoxanthinagainst UVB-Induced SkinPhotoaging in Hairless Mice
  5. Anti‐pigmentary activity of fucoxanthinand its influence on skinmRNA expression of melanogenic molecules
  6. Protective and therapeutic effects of fucoxanthinagainst sunburn caused by UV irradiation
  7. Chemical Stability and Skin Permeationof Fucoxanthin-Loaded Microemulsions
  8. FucoxanthinElicits Epigenetic Modifications, Nrf2 Activation and Blocking Transformation in Mouse Skin JB6 P+ Cells
  9. FucoxanthinProtects Cultured Human Keratinocytes against Oxidative Stressby Blocking Free Radicals and Inhibiting Apoptosis
  10. Comparative effects of β-carotene and fucoxanthinon retinol deficiency induced oxidative stressin rats
  11. Evaluation of anti-inflammatoryeffectof fucoxanthinisolated from brown algae in lipopolysaccharide-stimulated RAW 264.7 macrophages
  12. First Evidence for the Anti-inflammatoryActivity of Fucoxanthinin High-Fat-Diet-Induced Obesity in Mice and the Antioxidant Functions in PC12 Cells
  13. Fucoxanthinol, Metabolite of Fucoxanthin, Improves Obesity-Induced Inflammationin Adipocyte Cells
  14. FucoxanthinAmeliorates Inflammationand OxidativeReponses in Microglia
  15. Anti-Neuroinflammatory Effectsof Fucoxanthinvia Inhibition of Akt/NF-κB and MAPKs/AP-1 Pathways and Activation of PKA/CREB Pathway in Lipopolysaccharide-Activated BV-2 Microglial Cells
  16. Anti-inflammatoryeffectof fucoxanthinderivatives isolated from Sargassum siliquastrum in lipopolysaccharide-stimulated RAW 264.7 macrophage
  17. FucoxanthinInhibits the InflammationResponse in Paw Edema Model through Suppressing MAPKs, Akt, and NFκB
  18. Protective effects of fucoxanthinagainst ferric nitrilotriacetate-induced oxidative stressin murine hepatic BNL CL.2 cells
  19. Fucoxanthinrestrains Oxidative stressinduced by Retinol Deficiency through Modulation of Na+Ka+-ATPase and Antioxidant Enzyme activities in Rats
  20. Fucoxanthinrestrains oxidative stressinduced by retinol deficiency through modulation of Na+Ka+-ATPase and antioxidant enzyme activities in rats
  21. Protective effect of fucoxanthinisolated from Ishige okamurae against high-glucose induced oxidative stressin human umbilical vein endothelial cells and zebrafish model
  22. Fucoxanthinrestrains oxidative stressinduced by retinol deficiency through modulation of Na+Ka+-ATPase and antioxidant enzyme activities in rats
  23. Fucoxanthin, a marine carotenoid protects cadmium-induced oxidativerenal dysfunction in rats
  24. Fucoxanthincontent of Cylindrotheca Closterium and its oxidative stressmediated enhancement
  25. Fucoxanthin, the constituent of Laminaria japonica, triggers AMPK-mediated cytoprotection and autophagyin hepatocytes under oxidative stress
  26. Enhancing colour and oxidative stabilitiesof reduced-nitrite turkey meat sausages during refrigerated storage using fucoxanthinpurified from the Tunisian seaweed Cystoseira barbata
  27. Effects of fucoxanthinon lipopolysaccharide-induced inflammationin vitro and in vivo
  28. Fucoxanthininhibits theinflammatoryresponse by suppressing the activation of NF-κB and MAPKs in lipopolysaccharide-induced RAW 264.7 macrophages
  29. Low-molecular-weight fucoidan and high-stability fucoxanthinfrom brown seaweed exert prebiotics and anti-inflammatoryactivities in Caco-2 cells
  30. Undaria pinnatifida and FucoxanthinAmeliorate Lipogenesis and Markers of Both Inflammationand Cardiovascular Dysfunction in an Animal Model of Diet-Induced Obesity
  31. Inhibition of Ultraviolet B-Induced Expression of the Proinflammatory Cytokines TNF-α and VEGF in the Cornea by Fucoxanthin Treatment in a Rat Model

  1. Promotion of hairgrowthby ginseng radixon cultured mouse vibrissal hairfollicles
  2. Fructus panax ginseng extract promotes hairregenerationin C57BL/6 mice
  3. Simultaneous analysis of ginsenosides of various ginseng radix by HPLC
  4. Carbon dioxide extraction of ginseng root hairoiland ginsenosides
  5. Comparative HairRestorer Efficacyof Medicinal Herb on Nude (Foxn) Mice
  6. Protective effect of Korean Red Ginseng against chemotherapeutic drug-induced premature catagen development assessed with human hairfollicleorgan culture model
  7. Compositions and methods of inducing hairgrowthutilizing Continus coggygria
  8. Hair-GrowthPotential of Ginsengand Its Major Metabolites: A Review on Its Molecular Mechanisms
  9. Determinations of Trilinolein and 1,2– Dilinoleoyl-3-Oleoyl-Glycerol in Various Panax Ginseng by HPLC
  10. Panax ginseng extractantagonizes the effect of DKK‑1-induced catagen-like changes of hairfollicles
  11. Experimental Study on the Effects of the Extract of Ginseng Radixet Rhizoma on HairGrowthof C57BL/6J Mice
  12. Introduction of hemopoiesis by Saenghyuldan a mixture of Ginseng Radix, Paeoniae Radix Alba, and Hominis Placenta Extracts.
  13. The Effects of Ginseng RadixRubra on Human Vascular Endothelial Cells
  14. Effect of Radix Ginsengand Radix Trichosanthis on the Melanogenesis
  15. Effects of Red Ginseng extracton ultraviolet B‐irradiated skin change in C57BL mice
  16. Effects of EGb 761 and Korean Red Ginseng on Melanogenesisin B16F10 Melanoma Cells and Protection Against UVB Irradiationin Murine Skin
  17. Protective effects of Panax ginseng on muscle injury and inflammationafter eccentric exercise
  18. The chemopreventive potential and anti-inflammatoryactivitiesof Korean black ginsengin colon26-M3.1 carcinoma cells and macrophages
  19. Anti-inflammatorymechanism of ginsengsaponins in activated microglia
  20. COMBINATION EFFECTS OF SHOSAIKOTO (CHINESE TRADITIONAL MEDICINE) AND PREDNISOLONE ON THE ANTI-INFLAMMATORYACTION
  21. Panax notoginseng attenuates LPS-induced pro-inflammatorymediators in RAW264.7 cells
  22. TheEffectsofKoreanRedGinseng(GinsengRadixRubra)onLiverRegenerationafterPartialHepatectomyinDogs
  23. Pectinase-Processed Ginseng Radix (GINST) Ameliorates Hyperglycemia and Hyperlipidemiain High Fat Diet-Fed ICR Mice
  24. Hepatoprotective Effects of Chinese Medicinal Herbs: A Focus on Anti-Inflammatoryand Anti-Oxidative Activities
  25. A Natural Compound (Ginsenoside Re) Isolated from Panax ginseng as a Novel Angiogenic Agentfor Tissue Regeneration
  26. Effects of the Chinese Herbal Medicines Bupleuri radix, Ginseng radix,and Zingiberis rhizoma on Lymphatic Vessel Activity in Rats
  27. Screening for Anti-inflammatoryActivitiesin Extracts from Korean Herb Medicines
  28. Anti-Inflammatoryand Antimicrobial Effectsof a Novel Herbal Formulation (WSY-1075) in a Chronic Bacterial Prostatitis Rat Model
  29. Effect of Korean Red Ginseng on Testicular Tissue Injuryafter Torsion and Detorsion
  30. Neuroprotection in Diabetic Encephalopathy
  31. Ginseng radix induces apoptosis in HL-60 cells and its mechanism as little relation with TNF-α production

  1. Angiogenic and proliferative effects of the cytokineVEGF in Ehrlich ascites tumor cells is inhibited by Glycyrrhiza glabra
  2. Licocalchone-C Extracted from Glycyrrhiza GlabraInhibits Lipopolysaccharide-Interferon-γ Inflammationby Improving Antioxidant Conditions and Regulating Inducible Nitric Oxide SynthaseExpression
  3. Glycyrrhiza glabra L.Extract Inhibits LPS-Induced Inflammationin RAW Macrophages
  4. A Licorice ExtractReduces Lipopolysaccharide‐Induced Proinflammatory CytokineSecretion by Macrophages and Whole Blood
  5. HairGrowthPromotant Activity of Petroleum Ether Root Extract of Glycyrrhiza Glabra L(Fabaceae) in Female Rats
  6. HAIRGROWTHSTIMULATING EFFECT AND PHYTOCHEMICAL EVALUATION OF HYDRO-ALCOHOLIC EXTRACT OF GLYCYRRHIZA GLABRA
  7. GLYCYRRHIZA GLABRAEXTRACT CREAM: EFFECTS ON SKIN PIGMENT “MELANIN”
  8. Modulation of lipopolysaccharide-induced pro-inflammatorymediators by an extract of Glycyrrhiza glabraand its phytoconstituents
  9. Protection of Mitochondrial Functions against Oxidative Stressesby Isoflavans from Glycyrrhiza glabra
  10. Protective activity of Glycyrrhiza glabra Linn. on carbon tetrachloride-induced peroxidative damage
  11. Anti-convulsant action and amelioration of oxidative stressby Glycyrrhiza glabra rootextract in pentylenetetrazole- induced seizure in albino rats
  12. In vitro studies on protective effect of Glycyrrhiza glabraroot extracts against cadmium-induced genetic and oxidative damagein human lymphocytes
  13. Amelioration of oxidative stressinduced by oxidative mutagens and COX-2 inhibitory activity of umbelliferone isolated from Glycyrrhiza glabra L
  14. In vivoantioxidant and hepatoprotective potential of Glycyrrhiza glabraextracton carbon tetra chloride(CCl4)induced oxidative-stressmediated hepatotoxicity
  15. Modulation of genotoxicity of oxidative mutagensby glycyrrhizic acid from Glycyrrhiza glabra L.
  16. New insights into the antioxidant and apoptotic potential of Glycyrrhiza glabra L. during hydrogen peroxide mediated oxidative stress: An in vitro and in silico evaluation
  17. The Effects of Glycyrrhiza glabra L. extract use with aerobic training on inflammatoryfactorsand cognitive state in elderly with mild cognitive impairment
  18. Anti-InflammatoryEffectsof Glycyrrhiza glabra LinneExtract in a Dextran Sulfate Sodium-Induced Colitis Mouse Model

  1. Grape seed proanthocyanidin extract (GSPE)differentially regulates Foxp3+ regulatory and IL-17+ pathogenicT cell in autoimmune arthritis
  2. Proanthocyanidinsfrom the bark of Metasequoia glyptostroboides ameliorate allergic contact dermatitis through directly inhibiting T cells activation and Th1/Th17 responses
  3. Grape seed proanthocyanidinextract has potent anti-arthritic effects on collagen-induced arthritis by modifying the T cell balance
  4. Grape Seed Proanthocyanidin ExtractProtects Against Carrageenan-Induced Lung Inflammationin Mice Through Reduction of Pro-inflammatory Markers and Chemokine Expressions
  5. Proanthocyanidins: novel treatment for psoriasis that reduces oxidative stressand modulates Th17 and Treg cells
  6. Grape-Seed Proanthocyanidin Extractas Suppressors of Bone Destruction inInflammatoryAutoimmune Arthritis
  7. Anti-InflammatoryActivityof a Polymeric Proanthocyanidinfrom Serjania schiedeana
  8. Grape seed proanthocyanidin extractinhibits interleukin-17-induced interleukin-6 productionvia MAPK pathway in human pulmonary epithelial cells
  9. Effects of grape seed proanthocyanidinextract on airway inflammationand Treg/Th17 balancein asthmatic mice
  10. Anti-inflammatoryand Anti-melanogenic ProanthocyanidinOligomers from Peanut Skin
  11. Dietary grape-seed proanthocyanidininhibition of ultraviolet B-induced immune suppression is associated with induction of IL-12
  12. Grape Seed Proanthocyanidin ExtractAttenuates Allergic Inflammationin Murine Models of Asthma
  13. Protective Effects of Proanthocyanidinon Cerulein-induced Acute Pancreatic Inflammationin Rats
  14. Grape Seed Proanthocyanidin ExtractAttenuates Airway Inflammationand Hyperresponsiveness in a Murine Model of Asthma by Downregulating Inducible Nitric Oxide Synthase
  15. Cranberry proanthocyanidinsinhibit the adherence properties of Candida albicans and cytokine secretionby oral epithelial cells
  16. Proanthocyanidinprotects against cisplatin‐induced oxidative liver damagethrough inhibition of inflammationand NF‐κβ/TLR‐4 pathway
  17. Proanthocyanidin from grape seed extractinhibits airway inflammationand remodeling in a murine model of chronic asthma.
  18. Grape Seed Proanthocyanidin Extract–Mediated Regulation of STAT3 Proteins Contributes to Treg Differentiation and Attenuates Inflammationin a Murine Model of Obesity-Associated Arthritis
  19. Grape seed proanthocyanidin extractameliorates inflammationand adiposity by modulating gut microbiota in high‐fat diet mice
  20. Anti-inflammatoryeffectsof proanthocyanidin-richred rice extract via suppression of MAPK, AP-1 and NF-κB pathways in Raw 264.7 macrophages
  21. Gastroprotective Effects of Grape Seed Proanthocyanidin Extractsagainst Nonsteroid Anti-InflammatoryDrug-Induced Gastric Injury in Rats
  22. Comparison of the Anti-inflammatoryEffectsof Proanthocyanidin,Quercetin, and Damnacanthal on Benzo(a)pyrene Exposed A549 Alveolar Cell Line
  23. Protective effect of grape seed proanthocyanidin extractagainst oxidative stressinducedby cisplatin in rats
  24. Effects of Grape Seed Proanthocyanidin Extracton Oxidative StressInducedby Diabetes in Rat Kidney
  25. Back‐regulation of six oxidative stressproteins with grape seed proanthocyanidin extractsin rat diabetic nephropathy
  26. Protection of Primary Glial Cells by Grape Seed Proanthocyanidin Extractagainst Nitrosative/ Oxidative Stress
  27. Low molecular proanthocyanidindietary biofactor Oligonol: Its modulation of oxidative stress, bioefficacy, neuroprotection, food application and chemoprevention potentials
  28. Proanthocyanidinprevents methotrexate-induced intestinal damage and oxidative stress
  29. Activin, a Grape Seed-derived ProanthocyanidinExtract, Reduces Plasma Levels of Oxidative Stressand Adhesion Molecules (ICAM-1, VCAM-1 and E-selectin) in Systemic Sclerosis
  30. Acute and chronic stress-induced oxidativegastrointestinal injury in rats, and the protective ability of a novel grape seed proanthocyanidin extract
  31. Oral Administration of Grape Seed Proanthocyanidin Extracts Downregulate RAGE Dependant Nuclear Factor- Kappa BP65 Expression in the Hippocampus of Streptozotocin Induced Diabetic Rats
  32. Effect of Proanthocyanidin on Expression of Nuclear Factor kappa B and Interleukin-6 in Rats after Spinal Cord Injury

  1. Antiasthmatic Effects of Hesperidin,a Potential Th2 Cytokine Antagonist, in a Mouse Model of Allergic Asthma
  2. Hesperidinameliorates immunological outcome and reduces neuroinflammationin the mouse model of multiple sclerosis
  3. Hesperidinmethyl chalcone inhibits oxidative stressand inflammationin a mouse model of ultraviolet B irradiation-induced skin damage
  4. Experimental immunology
    Differential effect of hesperidin on Th1, Th2, Th17, and proinflammatory cytokinesproduction from splenocyte of Schistosoma mansoni-infected mice
  5. Hesperidinprotects gentamicin-induced nephrotoxicity via Nrf2/HO-1 signaling and inhibits inflammationmediated by NF-κB in rats
  6. Hesperidinand naringin attenuate hyperglycemia-mediated oxidative stressand proinflammatory cytokineproduction in high fat fed/streptozotocin-induced type 2 diabetic rats
  7. Hesperidininhibits expression of hypoxia inducible factor-1 alpha and inflammatorycytokine productionfrom mast cells
  8. Oral administration of hesperidin, a citrus flavonone, in ratscounteracts the oxidative stress, the inflammatorycytokineproduction,and the hepatotoxicity induced by the ingestion of2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
  9. Hesperidinreverses cognitive and depressive disturbances induced by olfactory bulbectomy in mice by modulating hippocampal neurotrophins and cytokine levelsand acetylcholinesterase activity
  10. HesperidinSuppresses Ovalbumin-Induced Airway Inflammationin a Mouse Allergic Asthma Model
  11. Hesperidinprotects against cyclophosphamide-induced hepatotoxicity by upregulation of PPARγ and abrogation of oxidative stressand inflammation
  12. HesperidinInhibits Inflammatory ResponseInduced by Aeromonas hydrophila Infection and Alters CD4+/CD8+ T Cell Ratio
  13. Antiinflammatory Effectsof Traditional Korean Medicine, JinPi‐tang and Its Active Ingredient, Hesperidinin HaCaT cells
  14. Antioxidant and anti-inflammatorypotentialof hesperidinagainst 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced experimental Parkinson’s disease in mice
  15. Exposure to Zinc Oxide Nanoparticles Induces Neurotoxicity and Proinflammatory Response: Amelioration by Hesperidin
  16. HesperidinAlleviates Lipopolysaccharide-Induced Neuroinflammationin Mice by Promoting the miRNA-132 Pathway
  17. Hesperidin ameliorates UV radiation-induced skin damage by abrogation of oxidative stressandinflammatoryin HaCaT cells
  18. Hesperidinalleviates rat postoperative ileus through anti-inflammationand stimulation of Ca2+-dependent myosin phosphorylation
  19. Evaluation of antioxidative and anti-inflammatorypotential of hesperidinand naringin on the rat air pouch model of inflammation
  20. Inhibitory effect of Hesperidinon tumour initiation and promotion in mouse skin
  21. Preventive effect of hesperidin against inflammationin CD-1 mouse skin caused by tumor promoter.
  22. Photoprotection by honeybush extracts, hesperidinand mangiferin against UVB-induced skin damagein SKH-1 mice
  23. Topical hesperidinimproves epidermal permeability barrier function and epidermal differentiation in normal murine skin
  24. Capillary resistance in the skinof rats fed flavone-free and atherogenic diets, and their response to hesperidin-methyl-chalcone.
  25. Topical formulation containing hesperidinmethyl chalcone inhibits skin oxidative stressand inflammationinduced by ultraviolet B irradiation
  26. Topical hesperidinprevents glucocorticoid‐induced abnormalities in epidermal barrier function in murine skin
  27. Detection of Hesperidinin Orange Skinby the UV-VIS Spectrophotometry
  28. HesperidinSuppresses MelanosomeTransport by Blocking the Interaction of Rab27A-Melanophilin
  29. Effect of topical application of hesperidin,aescin and tanshinone on finger nailfold skinmicrocirculation
  30. Articels : Hesperidin Improves the IL-6-Mediated Hepatic Insulin Resistance in Hepa-1c1c7 Cells
  31. Articels : Hesperidin Ameliorates TNF-α-Mediated Insulin Resistance in Differentiated 3T3-L1 Cells
  32. Effect of hesperidin on lipid peroxidation and TNF-α of alcoholic fatty liver disease in rats
  33. Effect Of Hesperidin In Bleomycin-Induced Pulmonary Fibrosis In Rats: Critical Role Of NRF-2, TNF-Α, AND IL-1Β
  34. Influence of Hesperidin Pretreatment on the Expression of TNF-α and IFN-γ in Concanavalin A-induced Acute Liver Injury in Mice
  35. Influence of Hesperidin on the Expression of TNF-α and IFN-γ in Concanavalin Ainduced Acute Liver Injury in Mice
  36. Kappa-opioid receptors mediate the antidepressant-like activity of hesperidin in the mouse forced swimming test

  1. Characterization of the mucilages extracted fromhibiscus rosa-sinensis linnand hibiscus mutabilis linn andtheir skin moisturizing effect
  2. Antidepressant-like activityof anthocyanidins fromHibiscus rosa-sinensis flowersin tail suspension test and forced swim test
  3. ANTI-INFLAMMATORYEFFECTS OFHIBISCUS ROSA-SINENSIS L.AND Hibiscus ROSA-SINENSIS VAR.ALBAETHANOL EXTRACTS
  4. Effect of hydroalcoholic extract ofHibiscus rosa sinensis Linn.leaves inexperimental colitis in rats
  5. A survey onHibiscus rosa—sinensis, Alcea rosea L. and Malva neglecta Wallr asantibacterial agents
  6. Antihyperlipidemic EffectofEthanolic Extract ofHibiscus rosa sinensisFlowersin Hyperlipidemic Rats
  7. Study on prevention of two-stage skin carcinogenesis byHibiscus rosa sinensis extractand the role of its chemical constituent, gentisic acid, in the inhibition of tumour promotion response andoxidative stress in mice
  8. Antioxidant and antibacterial activities of Hibiscus Rosa-sinensis Linn flower extracts
  9. Mechanisms Involved in Toxicity of Liver Caused by Piroxicam in Mice and Protective Effects of Leaf Extract ofHibiscus Rosa-Sinensis L.
  10. ANTI-PYRETIC ACTIONOF CAULERPA LENTILLIFERA,HIBISCUS ROSA-SINENSIS,AND PIPER SARMENTOSUM AQUEOUS EXTRACT IN MICE
  11. Evaluation ofAntioxidant,Toxicological and wound healing Properties ofHibiscus rosa-sinensisL.(Malvaceae) ethanolic leaves extract on different Experimental animal models
  12. Polyphenols richHibiscus rosa sinensis Linn.petals modulate diabetic stress signalling pathways in streptozotocin-induced experimental diabetic rats
  13. Gastroprotective effect of flower extracts ofHibiscus rosa sinensisagainstacute gastric lesion modelsin rodents
  14. Antibacterial, antioxidantand phytochemical screening ofHibiscus rosa sinensis,Acorus calamus, Cucurbita maxima and Moringa oliefera
  15. EVALUATION OFANTI INFLAMMATORYACTIVITYOFHIBISCUS ROSA SINENSIS Linn.FLOWER EXTRACT IN RATS.
  16. In-vitro antioxidant activityand phytochemical analysis in extracts ofHibiscus rosa-sinensisstem and leaves
  17. Hypoglycemic and hypolipidemic activity of Hibiscus rosa sinensis Linnon streptozotocin–induced diabetic rats
  18. In vivo and in vitro evaluation ofhairgrowthpotentialofHibiscus rosa-sinensis Linn.
  19. The Floral Nectaries ofHibiscus rosa-sinensis: 1. Development of theSecretory Hairs
  20. Traditional medicinal uses ofHibiscus rosa-sinensis
  21. Effect of ethanolic extract ofHibiscus rosa sinensis L.,flowers onhairgrowthin female wistar rats
  22. Preparation, evaluation andhairgrowthstimulating activity of herbal hairoil
  23. Hibiscus rosa sinensis Linn– ‘‘Rudrapuspa’’ : A Review
  24. Post-CoitalAntifertility Activity of Hibiscus rosa-sinensis Linn. Roots
  25. Comparative Screening of Immunomodulatory Activity of Hydro-alcoholic Extract ofHibiscus rosa sinensis Linn.and Ethanolic Extract of Cleome gynandra Linn
  26. Cytotoxicity ofHibiscus rosa-sinensis flower extract
  27. Evaluation of thewound-healing activityofHibiscus rosa sinensis L(Malvaceae) in Wistar albino rats
  28. Evaluation of comparative antioxidant potentialof four cultivars ofHibiscus rosa-sinensis L.by HPLC-DPPH method
  29. Effect ofHibiscus rosa sinensis Extracton Hyperproliferation andOxidative DamageCaused by Benzoyl Peroxide and Ultraviolet Radiations in Mouse Skin
  30. Preliminary phytochemical andantiulcer studies ofHibiscus rosa sinensis Linn. root extracts
  31. Functional Jelly Drink as Source of Dietary Fiber and Vitamin C Consisting of Kappa Carrageenan, Konjac Glucomannan and Hibiscus sabdariffa, Linn Extract

Effect of Herbal Complex Extract Including Houttuynia cordataThunb on Hair GrowthPromotionin C57BL/6 Mice

  1. Structures, Components and Functions of Secretory Tissues in Houttuynia cordata
  2. Antioxidative Effectsof Polyphenols in Leaves of Houttuynia cordataon Protein Fragmentation by Copper–Hydrogen Peroxide In Vitro
  3. Houttuynia cordataThunb: A Review of Phytochemistry and Pharmacology and Quality Control
  4. Screening of Some Crude Plant Extracts for Their Acaricidal and Insecticidal Efficacies
  5. Hair growthinhibitorsand compositions containing the same
  6. Determination of As,Hg and 666,DDT of different Houttuynia cordata Accessions
  7. Antiproliferative Activityand Induction of Apoptosis in Human Melanoma Cellsby Houttuynia cordataThunb Extract
  8. Antioxidants for Healthy Skin: The Emerging Role of Aryl Hydrocarbon Receptors and Nuclear Factor-Erythroid 2-Related Factor-2
  9. Decoction and Fermentation of Selected Medicinal Herbs Promote Hair Regrowthby Inducing Hair FollicleGrowthin Conjunction with Wnts Signaling
  10. An Asian traditional herbal complex containing Houttuynia cordata Thunb,Perilla frutescens Var. acuta and green tea stimulates hair growthin mice
  11. Anti-inflammatoryeffectsof a Houttuynia cordatasupercritical extract
  12. Flavonoids from the aerial parts of Houttuynia cordataattenuate lung inflammationin mice
  13. Protective effects from Houttuynia cordataaqueous extract against acetaminophen-induced liver injury
  14. Houttuynia cordata Thunbinhibits the production of pro‑inflammatory cytokines through inhibition of the NFκB signaling pathway in HMC‑1 human mast cells
  15. Anti-inflammatoryeffects of Houttuynia cordatasupercritical extract in carrageenan-air pouch inflammationmodel
  16. Anti-Neuroinflammatory Effects of Houttuynia cordataExtract on LPS-Stimulated BV-2 Microglia
  17. In vitro and Ex vivo Supplementation of Houttuynia cordataExtract and Immunomodulating Effect in Mice
  18. Protective effects of Houttuynia cordataaqueous extract in mice consuming a high saturated fat diet
  19. An ethyl acetate fraction derived from Houttuynia cordataextract inhibits the production of inflammatorymarkers by suppressing NF-кBand MAPK activation in lipopolysaccharide-stimulated RAW 264.7 macrophages
  20. Houttuynia cordataThunb reverses oxaliplatin-induced neuropathic pain in rat by regulating Th17/Treg balance
  21. Paeonia japonica, Houttuynia cordata, and Aster scaber Water Extracts Induce Nitric Oxide and Cytokine Production by Lipopolysaccharide-Activated Macrophages
  22. Houttuynia cordataaqueous extract attenuated glycative and oxidative stressin heart and kidney of diabetic mice
  23. Effect of Natural Extracts Mixture from Houttuynia cordataand Ulmus davidiana var. japonica in Mast Cell-Induced Allergic InflammatoryResponse
  24. Vaginal innate immune mediators are modulated by a water extract of Houttuynia cordata Thunb
  25. Houttuynia cordatasuppresses the Aggregatibacter actinomycetemcomitans-induced increase of inflammatory-related genes in cultured human gingival epithelial cells
  26. Houttuynia cordatawater extract suppresses anaphylactic reaction and IgE-mediated allergic response by inhibiting multiple steps of FcεRI signaling in mast cells
  27. Therapeutic potentials of Houttuynia cordataThunb. against inflammationand oxidative stress: A review
  28. Anti-InflammatoryActivity of Houttuynia cordataagainst Lipoteichoic Acid-Induced Inflammation in Human Dermal Fibroblasts
  29. Pharmaceutical Impact of Houttuynia Cordataand Metformin Combination on High-Fat-Diet-Induced Metabolic Disorders: Link to Intestinal Microbiota and Metabolic Endotoxemia
  30. Effects of Volatile Oil and 2-Undecanone from Houttuynia Cordata Thunb. on LPS-TLR4/MD-2-TNF-α Inflammation Signaling Pathway

  1. Use of hydroxytyrosolas anti-aging agent
  2. Peracetylated hydroxytyrosol, a new hydroxytyrosol derivate, attenuates LPS-inducedinflammatoryresponse in murine peritoneal macrophages via regulation of non-canonical inflammasome, Nrf2/HO1 and JAK/STAT signaling pathways
  3. Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammationand rheumatoid arthritis
  4. Skin deliveryof antioxidant surfactants based on gallic acid and hydroxytyrosol
  5. Inhibition of tyrosinase activity and melanine pigmentationby 2-hydroxytyrosol
  6. Hydroxytyrosolinhibits pro-inflammatory cytokines, iNOS, and COX-2 expression in human monocytic cells
  7. HydroxytyrosolIs the Major Anti-InflammatoryCompound in Aqueous Olive Extracts and Impairs Cytokine and Chemokine Productionin Macrophages
  8. Effects of hydroxytyrosol‐20on carrageenan‐induced acute inflammationand hyperalgesia in rats
  9. Suppressive Effects of Hydroxytyrosolon Oxidative Stressand Nuclear Factor-κB Activation in THP-1 Cells
  10. Hydroxytyrosolprevents metabolic impairment reducing hepatic inflammationand restoring duodenal integrity in a rat model of NAFLD
  11. Oleic acid, hydroxytyrosoland n-3 fatty acids collectively modulate colitis through reduction of oxidative stressand IL-8 synthesis;in vitro and in vivo studies
  12. Anti-inflammatoryactivityof hydroxytyrosol– Inhibition of cytokine productionin a parkinson’s model system of neuroinflammation
  13. Role of the inhibition of oxidative stressand inflammatorymediators in the neuroprotective effects of hydroxytyrosolin rat brain slices subjected to hypoxia reoxygenation
  14. Nutritionally relevant concentrations of resveratrol and hydroxytyrosolmitigate oxidative burst of human granulocytes and monocytes and the production of pro-inflammatory mediatorsin LPS-stimulated RAW 264.7 macrophages
  15. Quercetin and hydroxytyrosolattenuates xanthine/xanthine oxidase-induced toxicity in H9c2 cardiomyocytes by regulation of oxidative stressand stress-sensitive signaling pathways
  16. Anti-Inflammatoryand Antitumor Effects of Hydroxytyrosolbut Not Oleuropein on Experimental Glioma In Vivo. A Putative Role for the Renin-Angiotensin System
  17. Hydroxytyrosolexerts an anti-inflammatoryeffect by suppressing Toll-like receptor 2 and TLR 2 downstream pathways in Staphylococcus aureus-induced mastitis in mice
  18. Hydroxytyrosolinhibits the inflammatoryresponseof osteoarthritis chondrocytes via SIRT6-mediated autophagy
  19. Antiproliferative, Antioxidant and Anti-inflammatoryEffects of Hydroxytyrosolon Human Hepatoma HepG2 and Hep3B Cell Lines
  20. Influence of olive-derived hydroxytyrosolon the toll-like receptor 4-dependentinflammatoryresponse of mouse peritoneal macrophages
  21. Hydroxytyrosolmodulates the levels of microRNA-9 and its target sirtuin-1 thereby counteracting oxidative stress-inducedchondrocyte death
  22. Hydroxytyrosoland oleuropein from olive leaves: Potent anti-inflammatoryandanalgesic activities
  23. Olive Phenol HydroxytyrosolPrevents Passive Smoking–Induced Oxidative Stress
  24. Hydroxytyrosolprotects retinal pigment epithelial cells from acrolein‐induced oxidative stressand mitochondrial dysfunction
  25. Olive oil hydroxytyrosolprotects human erythrocytes against oxidative damages
  26. Stimulation of GSH synthesis to prevent oxidative stress-inducedapoptosis by hydroxytyrosolin human retinal pigment epithelial cells: activation of Nrf2 and JNK-p62/SQSTM1 pathways
  27. The olive oil antioxidant hydroxytyrosolefficiently protects against the oxidative stress-induced impairment of the NO• response of isolated rat aorta
  28. Protective effect of hydroxytyrosoland tyrosol against oxidative stressin kidney cells
  29. Olive oil hydroxytyrosolreduces toxicity evoked by acrylamide in human Caco-2 cells by preventing oxidative stress
  30. Protective Effects of Synthetic HydroxytyrosolAcetyl Derivatives against Oxidative Stressin Human Cells
  31. The hydroxytyrosol-dependent increase of TNF-α in LPS-activated human monocytes is mediated by PGE2 and adenylate cyclase activation
  32. Hydroxytyrosol, a natural molecule from olive oil, suppresses the growth of human hepatocellular carcinoma cells via inactivating AKT and nuclear factor-kappa B pathways

 

  1. Inhibition of Th1/Th17 responsesvia suppression of STAT1 and STAT3 activation contributes to the amelioration of murine experimental colitis by a natural flavonoid glucoside icariin
  2. Regulation of Th17/Treg functioncontributes to the attenuation of chronic airway inflammationby icariinin ovalbumin-induced murine asthma model
  3. A natural flavonoid glucoside icariininhibits Th1 and Th17 cell differentiationand ameliorates experimental autoimmune encephalomyelitis
  4. A Natural Flavonoid Glucoside, Icariin,Regulates Th17and Alleviates Rheumatoid Arthritis in a Murine Model
  5. Icariininhibits LPS-induced cell inflammatoryresponseby promoting GRα nuclear translocation and upregulating GRα expression
  6. Chondroprotective effects and multi-target mechanisms of Icariinin IL-1 beta-inducedhuman SW 1353 chondrosarcoma cells and a rat osteoarthritis model
  7. Icariinprevents cytokine‑inducedβ‑cell death by inhibiting NF‑κB signaling
  8. Icariininhibits TNF-α/IFN-γ inducedinflammatoryresponse via inhibition of the substance P and p38-MAPK signaling pathway in human keratinocytes
  9. Icariinpromotes mouse hair folliclegrowthby increasing insulin‐like growthfactor 1 expression in dermal papillary cells
  10. Icariininduces cell differentiation and cell cycle arrest in mouse melanoma B16 cellsvia Erk1/2-p38-JNK-dependent pathway
  11. Effects of Icariinon Hypothalamic-Pituitary-Adrenal Axis Action and Cytokine Levelsin Stressed Sprague-Dawley Rats
  12. IcariinRegulates Expression of Cytokinesin Osteoblasts
  13. Icariinprotects against titanium particle-induced osteolysis and inflammatoryresponsein a mouse calvarial model
  14. Effects of icariinon cytokine-inducedankylosing spondylitis with fibroblastic osteogenesis and its molecular mechanism
  15. Attenuation of LPS-induced inflammationby ICT, a derivate of icariin, via inhibition of the CD14/TLR4 signaling pathway in human monocytes
  16. IcariinAttenuates High-cholesterol Diet Induced Atherosclerosis in Rats by Inhibition of InflammatoryResponse and p38 MAPK Signaling Pathway
  17. Inhibitory effects of icariinon melanogenesisof human epidermal melanocytes
  18. Icariininhibits inflammationvia immunomodulation of the cutaneous hypothalamus–pituitary–adrenal axis in vitro
  19. IcariinAttenuates Interleukin-1β-InducedInflammatoryResponse in Human Nucleus Pulposus Cells
  20. [Effects of icariinon inflammationmodel stimulated by lipopolysaccharide in vitro and in vivo].
  21. Icariinattenuates LPS-induced acuteinflammatoryresponses: Involvement of PI3K/Akt and NF-κB signaling pathway
  22. Inhibitory effect of icariinon Ti-inducedinflammatoryosteoclastogenesis
  23. Icariinprotects murine chondrocytes from lipopolysaccharide-inducedinflammatoryresponses and extracellular matrix degradation
  24. Effects of icariincombined with Panax notoginseng saponins on ischemia reperfusion‐induced cognitive impairments related with oxidative stressand CA1 of hippocampal neurons in rat
  25. IcariinPromotes Angiogenic Differentiation andPrevents Oxidative Stress-Induced AutophagyinEndothelial Progenitor Cells
  26. Icariinattenuates hypoxia‐induced oxidative stressand apoptosis in osteoblasts and preserves their osteogenic differentiation potential in vitro
  27. [Icariinreduces mitochondrial oxidative stressinjury in diabetic rat hearts].
  28. Icariinexerts an antidepressant effect in an unpredictable chronic mild stress model of depression in rats and is associated with the regulation of hippocampal neuroinflammation
  29. Protective effect of icariinon DNA against radical‐induced oxidative damage
  30. Icariinattenuated oxidative stressinduced-cardiac apoptosis by mitochondria protection and ERK activation
  31. STUDY OF SYNERGISTIC EFFECTS OF ICARIIN ON INDUCING IL-2、3、 6
  32. Icariin inhibits MMP‑1, MMP‑3 and MMP‑13 expression through MAPK pathways in IL‑1β‑stimulated SW1353 chondrosarcoma cells
  33. Icariin Intervenes in Cardiac Inflammaging through Upregulation of SIRT6 Enzyme Activity and Inhibition of the NF-Kappa B Pathway
  34. Icariin ameliorates IgA nephropathy by inhibition of nuclear factor kappa b/Nlrp3 pathway
  35. Icariin improves Fanconi anemia hematopoietic stem cell function through SIRT6-mediated NF-kappa B inhibition

  1. Agent for hair deforming treatment
  2. Phytochemistry and Biological Activity Perspectives of Rheum Species
  3. Isorhapontigenin, a bioavailable dietary polyphenol, suppresses airway epithelial cell inflammationthrough a corticosteroid‐independent mechanism
  4. Cardioprotective effect of resveratrol analogue isorhapontigeninversus omega-3 fatty acids in isoproterenol-induced myocardial infarction in rats
  5. Effect of isorhapontigeninon respiratory burst of rat neutrophils
  6. Piceatannol and Its Metabolite, Isorhapontigenin,Induce SIRT1Expressionin THP-1 Human Monocytic Cell Line
  7. An IsorhapontigeninTetramer and a Novel Stilbene Dimer from Gnetum hainanense
  8. The Chinese Herb Isolate IsorhapontigeninInduces Apoptosis in Human Cancer Cells by Down-regulating Overexpression of Antiapoptotic Protein XIAP
  9. Studies on formic acid-catalyzed dimerization of isorhapontigeninand of resveratrol to tetralins
  10. Isorhapontigenin, a new resveratrol analog, attenuates cardiac hypertrophy via blocking signaling transduction pathways
  11. Administration of the Resveratrol Analogues Isorhapontigeninand Heyneanol-A Protects Mice Hematopoietic Cellsagainst Irradiation Injuries
  12. Quantum Chemical Study on the AntioxidationMechanism of Piceatannol and Isorhapontigenintoward Hydroxyl and Hydroperoxyl Radicals
  13. A Theoretical Study on the Antioxidant Activityof Piceatannol and IsorhapontigeninScavenging Nitric Oxide and Nitrogen Dioxide Radicals
  14. Pre-clinical Pharmacokinetic and Metabolomic Analyses of Isorhapontigenin, a Dietary Resveratrol Derivative
  15. [Transport mechanism of isorhapontigeninbased on human intestinal Caco-2 cells].
  16. Induction of miR-137 by Isorhapontigenin(ISO) Directly Targets Sp1 Protein Translation and Mediates Its Anticancer Activity Both In Vitro and In Vivo

  1. Dietary Flavonoids as Therapeutics for Preterm Birth: Luteolin and KaempferolSuppress Inflammationin Human Gestational Tissues In Vitro
  2. Protective Effects of Kaempferolon Lipopolysaccharide-Induced Mastitis in Mice
  3. [Inhibitory effect of kaempferol on inflammatoryresponseof lipopolysaccharide-stimulated human mast cells].
  4. Dietary Kaempferol Suppresses Inflammationof Dextran Sulfate Sodium-Induced Colitis in Mice
  5. Protective Effect of Kaempferolon LPS plus ATP-Induced InflammatoryResponsein Cardiac Fibroblasts
  6. Kaempferolpretreatment modulates systemic inflammationand oxidative stressfollowing hemorrhagic shock in mice
  7. KaempferolAttenuates Myocardial Ischemic Injury via Inhibition of MAPK Signaling Pathwayin Experimental Model of Myocardial Ischemia-Reperfusion Injury
  8. Kaempferol Promotes Transplant Toleranceby Sustaining CD4+FoxP3+ Regulatory T Cells in the Presence of Calcineurin Inhibitor
  9. KaempferolInhibits P. intermedia Lipopolysaccharide‐Induced Production of Nitric Oxide Through Translational Regulation in Murine Macrophages: Critical Role of Heme Oxygenase‐1‐Mediated ROS Reduction
  10. STAT3 and NF-κB are common targets for kaempferol-mediated attenuation of COX-2 expression in IL-6-induced macrophagesand carrageenan-induced mouse paw edema
  11. Inhibition of LPS induced iNOS, COX-2 and cytokines expression by kaempferol-3-O-β-D-sophoroside through the NF-κB inactivation in RAW 264.7 cells [2008]
  12. Protective effect of kaempferol,a flavonoid widely present in varieties of edible plants, on IL-1β-induced inflammatoryresponsevia inhibiting MAPK, Akt, and NF-κB signalling in SW982 cells
  13. Kaempferol alleviates LPS-induced neuroinflammationand BBB dysfunction in mice via inhibiting HMGB1 release and down-regulating TLR4/MyD88 pathway
  14. Kaempferol inhibits the production of ROSto modulate OPN–αvβ3 integrin pathway in HUVECs
  15. Kaempferol impedes IL-32-induced monocyte-macrophage differentiation
  16. Kaempferolslows intervertebral disc degeneration by modifying LPS-induced osteogenesis/adipogenesis imbalance and inflammationresponsein BMSCs
  17. Expression of the xenobiotic metabolizing enzyme cytochrome P450 1B1 alters anti-inflammatoryactivityof quercetin, kaempferoland taxifolin in macrophage and monocyte (830.25)
  18. Effect of Cudrania tricuspidata and Kaempferolin Endoplasmic Reticulum Stress-Induced Inflammationand Hepatic Insulin Resistance in HepG2 Cells
  19. Kaempferol7-O-β-D-glucoside isolated from the leaves of Cudrania tricuspidata inhibits LPS-induced expression of pro-inflammatory mediators through inactivation of NF-κB, AP-1, and JAK-STAT in RAW 264.7 macrophages
  20. Procyanidin Oligomers Selectively and Intensively Promote Proliferation of Mouse Hair Epithelial Cells In Vitro and Activate Hair FollicleGrowthIn Vivo
  21. Hair GrowthPromotingand Anticancer Effects of p21-activated kinase 1 (PAK1) Inhibitors Isolated from Different Parts of Alpinia zerumbet
  22. Inhibitory effectsof quercetin and Kaempferolas two propolis derived flavonoids on Tyrosinase enzyme
  23. Methods and compounds for reducing allergic reactions to hair dyes
  24. Mechanism of action of herbs and their active constituents used in hair loss treatment
  25. Protection of burn-induced skin injuriesby the flavonoid kaempferol
  26. Stimulating effect of kaempferoland six traditional Chinese medicines on activation of tyrosinase
  27. Method For Preparing Kaempferol-3-0-Rutinoside and Composition of Skin External ApplicationComprising Thereof
  28. KaempferolRegulates Collagen Induced Oxidationof SHP-2 in Platelet Activation
  29. Antioxidantand Neuroprotective Effects of Kaempferoland Tannic Acid against 6-Hydroxydopamine-induced Oxidative Stress
  30. Composition for preventing hair lossand stimulating hair growth
  31. Kaempferol attenuates COX-2 expression in IL-6-induced macrophages and carrageenan-induced mouse paw edema by targeting STAT3 and NF-kB
  32. Down-regulation of iNOS and TNF-α expression by kaempferol via NF-κB inactivation in aged rat gingival tissues
  33. Downregulation in the mRNA expression of nuclearhormone receptor liver-X-receptor alpha (LXR-ααααα) byTNF-ααααα is abolished by the antioxidant kaempferol, butnot ascorbic acid, in human hepatocarcinoma HepG2cells
  34. Nicotinic acid, lauric acid and kaempferol abolish ATP-binding cassette transporter subfamily A member 1 (ABCA1) down-regulation by TNF-αin hepatocarcinoma HepG2 cell line.
  35. Inhibition of LPS induced iNOS, COX-2 and cytokines expression by kaempferol-3-O-β
    -D-sophoroside through the NF−κB
    inactivation in RAW 264.7 cells

  1. Effects of Kolaviron, the Major Constituent of Garciniakola, on the Histology of the Hypothalamus, Pituitary, and Testes Using Adult Male WistarRats as a Model Organism
  2. Hair growthcompositionsand methods of use
  3. Oral phenytoin protects against experimental cyclophosphamide-chemotherapy induced hair loss
  4. Kolaviron-Induced Inhibition of Lung Adencarcinoma (H1299) Cell Growthand Survival via PKA/PI3K Pathway
  5. Kolaviron, a natural flavonoid from the seeds of Garcinia kola, reduces LPS-induced inflammationin macrophagesby combined inhibition of IL-6secretion, and inflammatorytranscription factors, ERK1/2, NF-κB, p38, Akt, p-c-JUN and JNK
  6. Kolaviron, a Garcinia biflavonoid complex ameliorates hyperglycemia-mediated hepatic injury in rats via suppression of inflammatoryresponses
  7. Inhibition of neuroinflammationin BV2 microglia by the biflavonoid kolavironis dependent on the Nrf2/ARE antioxidant protective mechanism
  8. Kolavironprotects against benzo[a]pyrene-induced functional alterationsalong the brain-pituitary-gonadal axis in male rats
  9. Anti-inflammatoryeffects of kolavironmodulate the expressions of inflammatorymarker genes, inhibit transcription factors ERK1/2, p-JNK, NF-κB, and activate Akt expressions in the 93RS2 Sertoli cell lines
  10. Kolavironand selenium reduce hydrogen peroxide-induced alterations of the inflammatoryresponse
  11. The effects of Kolaviron, a Natural Flavonoid from the Seeds of Garcinia Kola on LPS-induced Inflammationin Macrophages
  12. Kolaviron Reduces Cadmium-induced Cytotoxicity and Production of Reactive Oxygen Species by Suppressing InflammatoryResponse
  13. Neuroprotective role of kolaviron in striatal redo-inflammationassociated with rotenone model of Parkinson’s disease
  14. Effects of kolaviron–a Garcinia kola biflavonoid on biochemical and histological parameters in streptozotocin – induced diabetes and diabetic complications (nephrotoxicity and hepatotoxicity)in male Wistar rats
  15. Renoprotection of Kolavironagainst benzo (A) pyrene-induced renal toxicity in rats
  16. Kolaviron, a Natural Antioxidant and Anti‐InflammatoryPhytochemical Prevents Dextran Sulphate Sodium‐Induced Colitis in Rats
  17. Analgesic and anti-inflammatoryeffects of kaviiron(a Garcinia kola seed extract)
  18. Kolaviron, a biflavonoid complex of Garcinia kola seeds modulates apoptosis by suppressing oxidative stressand inflammationin diabetes-induced nephrotoxic rats
  19. Kolaviron Improved Resistance to Oxidative Stressand Inflammationin the Blood (Erythrocyte, Serum, and Plasma) of Streptozotocin-Induced Diabetic Rats
  20. Anti-inflammatoryactivities of a kolaviron-inhibition of nitric oxide, prostaglandin E2 and tumor necrosis factor-alpha production in activated macrophage-like cell line.
  21. Kolaviron Improves Morbidityand Suppresses Mortality by Mitigating Oxido-Inflammationin BALB/c Mice Infected with Influenza Virus
  22. ANTI‐OXIDANT MECHANISMS OF KOLAVIRON:STUDIES ON SERUM LIPOPROTEIN OXIDATION, METAL CHELATION AND OXIDATIVE MEMBRANE DAMAGE IN RATS
  23. The Garcinia kola biflavonoid kolaviron attenuatesexperimental hepatotoxicity induced by diclofenac
  24. Kolavironwas protective against sodium azide (NaN3) induced oxidative stressin the prefrontal cortex
  25. Antinociceptive and anti-inflammatorypotentials of kolaviron: mechanisms of action
  26. Garcinia kola seed biflavonoid fraction (Kolaviron),increases longevityand attenuates rotenone-induced toxicity in Drosophila melanogaster
  27. Chemoprevention of aflatoxin B1-induced genotoxicity and hepatic oxidative damagein rats by kolaviron, a natural biflavonoid of Garcinia kola seeds
  28. Possible Protective Effectof Kolavironon CCl4-Induced Erythrocyte Damage in Rats
  29. KolavironModulates cellular redox status and impairment of membrane proteinactivities induced by potassium bromate (KBrO3) in rats
  30. Antioxidantand Scavenging Activities of Flavonoid Extract (Kolaviron)of Garcinia kola Seeds

  1. Prophylactic effects of Lonicera japonica extracton dextran sulphate sodium-induced colitis in a mouse model by the inhibition of the Th1/Th17 responsea>
  2. P01.12. Prophylactic effects of Lonicera japonica extracton dextran sulfate sodium-induced colitis in a mouse model by inhibition of the Th1/Th17 responsea>
  3. Luteolin Isolated from the Flowers of Lonicera japonicaSuppresses InflammatoryMediatorRelease by Blocking NF-κB and MAPKs Activation Pathways in HMC-1 Cells
  4. Wound repair and anti-inflammatorypotentialof Lonicera japonicain excision wound-induced rats
  5. Anti-inflammatoryeffectof the aqueous extract from Lonicera japonica floweris related to inhibition of NF-kappaB activation through reducing I-kappaBalpha degradation in rat liver.
  6. Inhibition of Experimental Systemic Inflammation(Septic Inflammation) and Chronic Bronchitis by New Phytoformula BL Containing Broussonetia papyrifera and Lonicera japonicaa>
  7. Anti-inflammatoryeffectof Lonicera japonicain proteinase-activated receptor 2-mediated paw edema
  8. Inhibitory Effect of Aqueous Extract from Lonicera japonica Floweron LPS-inducedInflammatoryMediators in RAW 264.7 Macrophages.
  9. Flavonoids Isolated from Flowers of Lonicera japonicaThunb. Inhibit InflammatoryResponsesin BV2 Microglial Cells by Suppressing TNF‐α and IL‐β Through PI3K/Akt/NF‐kb Signaling Pathways
  10. Loniceroside C, an AntiinflammatorySaponin from Lonicera japonicaa>
  11. Antiinflammatoryactivity of Lonicera japonicaa>
  12. Lonicera Japonica Inhibits Atopy Dermatitis in NC/Nga Mouse through Regulation of iNOS by NF-κB
    Suppression

  1. Anti-inflammatoryeffectsof luteolinon experimental autoimmune thyroiditis in mice
  2. Luteolin reduces inflammationin Staphylococcus aureus-induced mastitis by inhibiting NF-κB activation and MMPs expression
  3. Brain “fog,” inflammationand obesity: key aspects of neuropsychiatric disorders improved by luteolin
  4. Luteolinalleviates melanogenesis through regulation of oxidativeinsults
  5. Luteolinprotects mice from severe acute pancreatitis by exerting HO-1-mediated anti-inflammatoryand antioxidant effects
  6. Luteolin-7-glucoside inhibits IL-22/STAT3 pathway,reducing proliferation, acanthosis, and inflammationin keratinocytes and in mouse psoriatic model
  7. Luteolinattenuates airway inflammationby inducing the transition of CD4+CD25– to CD4+CD25+ regulatory T cells
  8. LuteolinPrevents Solar Radiation-Induced Matrix Metalloproteinase-1 Activation in Human Fibroblasts: A Role for p38 Mitogen-Activated Protein Kinase and Interleukin-20Released from Keratinocytes
  9. LuteolinSuppresses Cisplatin-Induced Apoptosis in Auditory Cells: Possible Mediation Through Induction of Heme Oxygenase-1 Expression
  10. LuteolinInhibits an Endotoxin-Stimulated Phosphorylation Cascade and Proinflammatory Cytokine Productionin Macrophages
  11. Luteolin inhibits cytokine expressionin endotoxin/cytokine-stimulated microglia
  12. Luteolin suppresses IL-1β-induced cytokinesand MMPs production via p38 MAPK, JNK, NF-kappaB and AP-1 activation in human synovial sarcoma cell line, SW982
  13. LuteolinReduces Lipopolysaccharide-induced Lethal Toxicity and Expression of Proinflammatory Moleculesin Mice
  14. LuteolinInhibits Hyperglycemia‐Induced Proinflammatory Cytokine Productionand Its Epigenetic Mechanism in Human Monocytes
  15. Antiasthmatic Activity of Luteolin-7-O-glucoside from Ailanthus altissima through the Downregulation of T Helper 2 Cytokine Expressionand Inhibition of Prostaglandin E2 Production in an Ovalbumin-Induced Asthma Model
  16. Luteolin suppresses inflammation-associated gene expression by blocking NF-κB and AP-1 activation pathway in mouse alveolar macrophages
  17. Anti-Inflammatoryand Antipruritic Effects of Luteolinfrom Perilla (P. frutescens L.) Leaves
  18. Inhibitory Effect of Perilla Leaf Extract and Luteolinon Mouse Skin TumorPromotion
  19. Luteolininhibits myelin basic protein‐induced human mast cell activation and mast cell‐dependentstimulation of Jurkat T cells
  20. Flavonoids such as Luteolin, Fisetin and Apigenin Are Inhibitors of Interleukin-4 and Interleukin-13Production by ActivatedHuman Basophils
  21. Modulatory effects of luteolinon osteoblastic function andinflammatorymediators in osteoblastic MC3T3‐E1 cells
  22. Luteolininhibits mast cell-mediated allergic inflammation.
  23. Chemical characterization and anti-inflammatoryactivity of luteolin glycosidesisolated from lemongrass
  24. Children with autism spectrum disorders, who improved with a luteolin-containing dietary formulation, show reduced serum levels of TNF and IL-6
  25. Inhibitory Effect of Luteolin4′-O-Glucoside from Kummerowia striata and Other Flavonoids on Interleukin-5 Bioactivity
  26. Biphasic effects of luteolinon interleukin-1β-inducedcyclooxygenase-2 expression in glioblastoma cells
  27. Luteolindecreases invasiveness, deactivates STAT3 signaling, and reverses interleukin-6induced epithelial–mesenchymal transition and matrix metalloproteinase secretion of pancreatic cancer cells
  28. Stimulated human melanocytes express and release interleukin‐8, which is inhibited by luteolin: relevance to early vitiligo
  29. Effects of Luteolinon the Release of Nitric Oxide and Interleukin‐6by Macrophages Stimulated With Lipopolysaccharide From Prevotella Intermedia
  30. Chlorogenic acid and luteolinsynergistically inhibit the proliferation of interleukin-1β-induced fibroblast-like synoviocytes through regulating the activation of NF-κB and JAK/STAT-signaling pathways
  31. Luteolin suppresses IL-1β-induced cytokines and MMPs production via p38 MAPK, JNK, NF-kappaB and AP-1 activation in human synovial sarcoma cell line, SW982
  32. Luteolin inhibited the gene expression, production and secretion of MUC5AC mucin via regulation of nuclear factor kappa B signaling pathway in human airway epithelial cells
  33. Luteolinattenuates adipocyte-derived inflammatory responses viasuppression ofNF-κB/MAPK pathway
  34. Luteolin attenuates TGF-beta 1-induced epithelial-mesenchymal transition of lung cancer cells by interfering in the PI3K/Akt-NF-kappa B-Snail pathway

  1. Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine
  2. The anthocyanin reduced Tomato Mutant Demonstrates the Role of Flavonols in Tomato Lateral Root and Root Hair Development
  3. Hair wavingnatural product: Dillenia indica seed sap
  4. Myricetin suppresses UVB-induced wrinkle formationand MMP-9 expression by inhibiting Raf
  5. Antioxidant activity of myricetinp resence of taurine
  6. Active combinations, compositions and methods for enhancing hair growth
  7. Effects of Myricetin on the Bioavaiiabilityand Pharmacokinetics of Tamoxifen and its Main Metabolite, 4-Hydroxytamoxifen in Rats
  8. Chemopreventive effect of Myricetin, a natural occurring compound, on colonic chronic inflammationand inflammation-driven tumorigenesis in mice
  9. Effects of Myricetin, an Antioxidant, CYP2C9, 2D6 and P-gp Inhibitor in vitro,on the Pharmacokinetics of Carvedilol in Rats
  10. Anti-inflammatoryactivityof myricetin-3-O-β-D-glucuronide and related compounds
  11. Myricetin inhibits IL-1β-induced inflammatorymediators in SW982 human synovial sarcoma cells
  12. Protective effect of myricetinin dextran sulphate sodium-induced murine ulcerative colitis
  13. Anti-inflammatoryactivity of myricetinfrom Diospyros lotus through suppression of NF-κB and STAT1 activation and Nrf2-mediated HO-1 induction in lipopolysaccharide-stimulated RAW264.7 macrophages
  14. Ameliorative effect of myricetinon insulin resistance in mice fed a high-fat, high-sucrose diet
  15. Myricetin: A Dietary Molecule with Diverse Biological Activities
  16. Dual Action of Myricetinon Porphyromonas gingivalis and the InflammatoryResponse of Host Cells: A Promising Therapeutic Molecule for Periodontal Diseases
  17. Antinociceptive and anti-inflammatoryeffects of myricetin3-O-β-galactoside isolated from Davilla elliptica: involvement of the nitrergic system
  18. Effect of Trimeric MyricetinRhamnoside (TMR) in Carrageenan‐induced Inflammationand Caecal Ligation and Puncture‐induced Lung Oxidative Stressin Mice
  19. Myricetin suppresses LPS-induced MMP expressionin human gingival fibroblasts and inhibits osteoclastogenesis by downregulating NFATc1 in RANKL-induced RAW 264.7 cells
  20. MKK4 is a novel target for the inhibition of tumor necrosis factor-α-induced vascular endothelial growthfactor expression by myricetin
  21. Protective effects of apigenin and myricetin against cisplatin-induced nephrotoxicityin mice
  22. Quercetin and its principalmetabolites, but notmyricetin, opposelipopolysaccharide-inducedhyporesponsivenessofthe porcine isolatedcoronary artery
  23. Myricetinprevents titanium particle-induced osteolysisin vivo and inhibits RANKL-induced osteoclastogenesis in vitro
  24. Myricetin Protects Against Cytokine-Induced Cell Deathin RIN-m5f β Cells
  25. Myricetin:biological activity related to human health
  26. Myricetin suppresses lipoteichoic acid‐induced interleukin‐1βand cyclooxygenase‐2 expression in human gingival fibroblasts
  27. Myricetin blocks lipoteichoic acid-induced COX-2 expression in human gingival fibroblasts
  28. Myricetinand quercetin are naturally occurring co-substrates of cyclooxygenases in vivo
  29. The dietary flavonoid myricetin regulates iron homeostasisby suppressing hepcidin expression
  30. Systems Pharmacology Dissection of the Protective Effect of Myricetin Against Acute Ischemia/Reperfusion-Induced Myocardial Injury in Isolated Rat Heart
  31. Research Article Myricetin Exerts Anti-osteoarthritic Effects in IL-1β Stimulated SW1353 Cells via Regulating Matrix Metalloproteinases and Modulating JNK
  32. Myricetin Down-Regulates Phorbol Ester-Induced Cyclooxygenase-2 Expression in Mouse Epidermal Cells by Blocking Activation of Nuclear Factor Kappa B

  1. Supplemental Naringenin Prevents Intestinal Barrier Defects and Inflammationin Colitic Mice
  2. Dietary naringeninsupplementation attenuates experimental autoimmune encephalomyelitis by modulating autoimmuneinflammatoryresponses in mice
  3. NaringeninInhibits UVB Irradiation-Induced Inflammationand Oxidative Stressin the Skinof Hairless Mice
  4. Naringeninis an inhibitor of T cell effectorfunctions
  5. Naringenininhibits osteoclastogenesis through modulation of helper T cells‐secreted IL‐4
  6. Regulation of InflammatoryCytokinesin Lipopolysaccharide-Stimulated RAW 264.7 Murine Macrophage by 7-O-Methyl-naringenin
  7. NaringeninSuppresses NeuroinflammatoryResponses Through Inducing Suppressor of CytokineSignaling 3 Expression
  8. Naringeninhas anti‐inflammatoryproperties in macrophage and ex vivo human whole‐blood models
  9. NaringeninInhibits Superoxide Anion-Induced InflammatoryPain: Role of Oxidative Stress,Cytokines,Nrf-2 and the NO−cGMP−PKG−KATPChannel Signaling Pathway
  10. Naringenininhibits allergen-induced airway inflammationand airway responsiveness and inhibits NF-κB activity in a murine model of asthma
  11. Flavonoid Naringenin: A Potential Immunomodulator for Chlamydia trachomatis Inflammation
  12. Naringeninreducesinflammatorypain in mice
  13. Anti-inflammatoryrole of naringeninin rats with ethanol induced liver injury
  14. An Eco‐Friendly Enantioselective Access to (R)‐Naringeninas Inhibitor of Proinflammatory CytokineRelease
  15. The citrus flavanone naringenininhibitsinflammatorysignalling in glial cells and protects against neuroinflammatory injury
  16. The citrus flavonone naringeninreduces lipopolysaccharide-induced inflammatorypainand leukocyte recruitment by inhibiting NF-κB activation
  17. NaringeninAmeliorates Acute Inflammationby Regulating Intracellular Cytokine Degradation
  18. Naringeninimproves the healing process of thermally-induced skin damagein rats
  19. In vitroHair GrowthPromotingEffects of Naringeninand Hesperetin on Human Dermal Papilla Cells and Keratinocytes
  20. Citrus flavanone naringeninenhances melanogenesisthrough the activation of Wnt/β-catenin signalling in mouse melanoma cells
  21. Anti-allergic Activity of NaringeninChalcone from a Tomato Skin Extract
  22. Skin carecompositions containing naringeninand/or quercetin and a retinoid
  23. Topical Formulation Containing Naringenin: Efficacy against Ultraviolet B Irradiation-Induced SkinInflammationand Oxidative Stressin Mice
  24. The inhibitory effect of naringeninon atopic dermatitisinduced by DNFB in NC/Nga mice
  25. Naringeninameliorates skin inflammationand accelerates phenotypic reprogramming from M1 to M2 macrophage polarization in atopic dermatitisNC/Nga mouse model.
  26. Effects of Naringeninon Inflammationin Complete Freund’s Adjuvant-Induced Arthritis by Regulating Bax/Bcl-2 Balance
  27. Naringeninprevents cholesterol-induced systemic inflammation, metabolic dysregulation, and atherosclerosis in Ldlr−/− mice
  28. Naringeninreduces cholesterol-induced hepatic inflammationin rats by modulating matrix metalloproteinases-2, 9 via inhibition of nuclear factor κB pathway
  29. Naringeninneutralises oxidative stressand nerve growthfactor discrepancy in experimental diabetic neuropathy
  30. Protective Effect of NaringeninAgainst Lead-Induced Oxidative Stressin Rats
  31. The citrus flavonoids hesperetin and naringenin block the lipolytic actions of TNF-α in mouse adipocytes
  32. Naringenin inhibits TNF-α induced VSMC proliferation and migration via induction of HO-1
  33. TNF-α Blocker Effect of Naringenin-Loaded Sericin Microparticles that Are Potentially Useful in the Treatment of Psoriasis
  34. Anti-inflammatory effect of naringin and naringenin on TNF-α secretion in cultured cortical astrocytes after stimulation with LPS
  35. Naringenin promotes recovery from colonic damage through suppression of epithelial TNF-αproduction and induction of M2-type macrophages in colitic mice [2019]
  36. Naringenin ameliorates streptozotocin-induced diabetic rat renal impairment by downregulation of TGF-β1 and IL-1 via modulation of oxidative stress correlates with decreased apoptotic events
  37. Naringenin: an immunomodulator of Interleukin (IL)-6, IL-8, and Tumor Necrosis Factor secretion from Chlamydia trachomatis-infected macrophages and epithelial cells (110.28)
  38. INHIBITORY EFFECT OF NARINGENIN AND NARINGIN ON IL-6AND IL-8 RELEASE: 60

  1. Protective Effect of NaringeninAgainst Lead-Induced Oxidative Stressin Rats
  2. Therapeutic Potential of Naringinfor Intervertebral Disc Degeneration: Involvement of AutophagyAgainst Oxidative Stress-Induced Apoptosis in Nucleus Pulposus Cells
  3. Mice pancreatic islets protection from oxidative stressinduced by single-walled carbon nanotubes through naringin
  4. Amelioration of autoimmune arthritis by naringinthrough modulation of T regulatory cells and Th1/Th2 cytokines
  5. NaringinAttenuates the Development of Carrageenan-Induced Acute Lung InflammationThrough Inhibition of NF-κb, STAT3 and Pro-Inflammatory Mediators and Enhancement of IκBα and Anti-InflammatoryCytokines
  6. Naringinprotects ultraviolet B-induced skin damageby regulating p38 MAPK signal pathway
  7. Naringin,a flavanone glycoside, promotes angiogenesis and inhibits endothelial apoptosis through modulation ofinflammatoryand growthfactor expression in diabetic foot ulcer in rats
  8. Naringinimproves random skin flapsurvival in rats
  9. NaringinProtects against Kainic Acid-Induced Status Epilepticus in Rats: Evidence for an Antioxidant, Anti-inflammatoryand NeuroprotectiveIntervention
  10. A novel ultradeformable liposomes of Naringinfor anti-inflammatorytherapy
  11. Study on the antiinflammationand analgesia of naringin
  12. Analysis of ionizing radiation‐induced DNA damageand repair in three‐dimensional human skin modelsystem
  13. Naringinameliorates pentylenetetrazol-induced seizures and associated oxidative stress,inflammation,and cognitive impairment in rats: Possible mechanisms of neuroprotection
  14. Naringinprevents ultraviolet‐B radiation‐induced oxidative damage and inflammationthrough activation of peroxisome proliferator‐activated receptor γ in mouse embryonic fibroblast (NIH‐3T3) cells
  15. NARINGINREVEALS AMELIORATIVE PROPERTY OVER ELEVATED OXIDATIVE STRESSLEVELS IN ANIMAL MODELS
  16. Wound healing potential of naringinointment formulation via regulating the expression of inflammatory,apoptotic and growthmediators in experimental rats
  17. NaringinInhibits Tumor Growthand Reduces Interleukin-6and Tumor Necrosis Factor α Levels in Rats with Walker 256 Carcinosarcoma
  18. Anti-InflammatoryEffectsof Naringinin Chronic Pulmonary Neutrophilic Inflammationin Cigarette Smoke-Exposed Rats
  19. Therapeutic effects of silymarin and naringinon methotrexate‐induced nephrotoxicity in rats: Biochemical evaluation of anti‐inflammatory,antiapoptotic, and antiautophagic properties
  20. NaringinProtects Ovalbumin-Induced Airway Inflammationin a Mouse Model of Asthma
  21. Naringinattenuates diabetic retinopathy by inhibiting inflammation, oxidative stressand NF-κB activation in vivo and in vitro
  22. Naringinprotects against cyclophosphamide-induced hepatotoxicity and nephrotoxicity through modulation of oxidative stress, inflammation,apoptosis, autophagy, and DNA damage
  23. NARINGINAND RUTIN PREVENT D-GALACTOSAMINE-INDUCED HEPATIC INJURY IN RATS VIA ATTENUATION OF THE INFLAMMATORYCASCADE AND OXIDATIVE STRESS
  24. Effect of naringinenzymatic hydrolysis towards naringenin on the anti-inflammatoryactivity of both compounds
  25. Naringinmodulates oxidative stressand inflammationin 3-nitropropionic acid-induced neurodegeneration through the activation of nuclear factor-erythroid 2-related factor-2 signalling pathway
  26. Naringinameliorates gentamicin-induced nephrotoxicity and associated mitochondrial dysfunction, apoptosis and inflammationin rats: Possible mechanism of nephroprotection
  27. Anti-inflammatoryactivity of naringinand the biosynthesised naringeninby naringinase immobilized in microstructured materials in a model of DSS-induced colitis in mice
  28. Naringinattenuates enhanced cough, airway hyperresponsiveness and airway inflammationin a guinea pig model of chronic bronchitis induced by cigarette smoke
  29. Protective role of naringinagainst cisplatin induced oxidative stress, inflammatoryresponseand apoptosis in rat striatum via suppressing ROS-mediated NF-κB and P53 signaling pathways
  30. NaringinAlleviates Diabetic Kidney Disease through Inhibiting Oxidative Stressand InflammatoryReaction
  31. Naringin ameliorates sodium arsenite-induced renal and hepatic toxicity in rats: decisive role of KIM-1, Caspase-3, TGF-β, and TNF-α
  32. Naringin rescued the TNF-α-induced inhibition of osteogenesis of bone marrow-derived mesenchymal stem cells by depressing the activation of NF-кB signaling pathway
  33. Naringin Decreases TNF-α and HMGB1 Release from LPS-Stimulated Macrophages and Improves Survival in a CLP-Induced Sepsis Mice
  34. Naringin Inhibits TNF-α Induced Oxidative Stress and Inflammatory Response in HUVECs via Nox4/NF-Κ B and PI3K/Akt Pathways
  35. Inhibition of TNF-α/IFN-γ induced RANTES expression in HaCaT cell by naringin

  1. Oleuropeinan Olive Oil Compound in Acute and Chronic InflammationModels: Facts and Perspectives
  2. Topical Application of OleuropeinInduces Anagen Hair Growthin Telogen Mouse Skin
  3. Pre-Initiation Effect of Oleuropeintowards Apoptotic and Oxidative StressLevelson the Early Development of Two-Stage Skin Carcinogenesis
  4. Olive Leaf Extract and Its Main Component OleuropeinPrevent Chronic Ultraviolet B Radiation-Induced Skin Damageand Carcinogenesis in Hairless Mice
  5. Evaluation of Effect of Oleuropeinon Skin WoundHealing in Aged Male Balb/c Mice
  6. Therapeutic Effects of Oleuropeinon Wounded Skinin Young Male Balb/c Mice
  7. OleuropeinDecreases Cyclooxygenase-2 and Interleukin-17 Expressionand AttenuatesInflammatoryDamage in Colonic Samples from Ulcerative Colitis Patients
  8. Oleuropeininhibited Th17 responseand reduced intestinal IL-17and IFN-γ release in dextran sulfate sodium (DSS)-induced acute colitis in C57BL/6 mice
  9. Oleuropeinalleviates malathion-induced oxidative stressand DNA damage in rats
  10. OC.14.4: Oleuropein Decreases Interleukin (IL)-17and Attenuates InflammatoryDamagein Colonic Mucosa from Ulcerative Colitis Patients
  11. Oleuropein Suppresses LPS-Induced InflammatoryResponses in RAW 264.7 Cell and Zebrafish
  12. Anti-InflammatoryEffectof Oleuropeinin Experimental Rat Spinal Cord Trauma
  13. Olive oil and its main phenolic micronutrient (oleuropein) prevent inflammation-induced bone loss in the ovariectomised rat
  14. Effects of oleuropeinon serum inflammatorycytokinesand histopathological changes in rats with pancreatitis.
  15. Oleuropeindown-regulated IL-1β-inducedinflammation and oxidative stressin human synovial fibroblast cell line SW982
  16. Effect of oleuropeinon cognitive deficits and changes in hippocampal brain-derived neurotrophic factor and cytokine expressionin a rat model of post-traumatic stress disorder
  17. Dose–response study of effect of oleuropein, an olive oil polyphenol, in an ovariectomy/inflammationexperimental model of bone loss in the rat
  18. Anti-inflammatoryeffectof oleuropeinon microglia through regulation of Drp1-dependent mitochondrial fission
  19. Oleuropeininhibits the IL-1β-induced expression ofinflammatorymediators by suppressing the activation of NF-κB and MAPKs in human osteoarthritis chondrocytes
  20. Oleuropeinprevents oxidativemyocardial injury induced by ischemia and reperfusion
  21. Antioxidant Status and Anti-inflammatoryEffectsofOleuropeinin Streptozotocin-induced Diabetic Nephropathy in Rats
  22. OleuropeinCurtails Pulmonary Inflammationand Tissue Destruction in Models of Experimental Asthma and Emphysema
  23. The leishmanicidal activity of oleuropeinis selectively regulated through inflammation- and oxidative stress-related genes
  24. Acute doxorubicin cardiotoxicity is successfully treated with the phytochemical oleuropeinthrough suppression of oxidative and nitrosative stress
  25. Association of genotypes affecting the expression of interleukin‐1βor interleukin‐1receptor antagonist with osteoarthritis
  26. Oleuropeinprotects against ethanol-induced oxidative stressand modulates sperm quality in the rat testis
  27. Oleuropeinimproves mitochondrial function to attenuate oxidative stressby activating the Nrf2 pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats
  28. Antioxidant effects of oleuropeinversus oxidative stressinduced by ethanol in the rat intestine
  29. Oleuropeinameliorates arsenic induced oxidative stressin mice
  30. Effect of oleuropeinagainst chemotherapy drug-induced histological changes, oxidative stress,and DNA damages in rat kidney injury

  1. Paeoniflorininhibitsinflammatoryresponses in mice with allergic contact dermatitis by regulating the balance between inflammatoryand anti-inflammatorycytokines
  2. Paeoniflorinprotects against lipopolysaccharide-induced acute lung injury in mice by alleviatinginflammatorycell infiltration and microvascular permeability
  3. PaeoniflorinInhibits Systemic Inflammationand Improves Survival in Experimental Sepsis
  4. Paeoniflorinattenuates allergic inflammationin asthmatic mice
  5. Paeoniflorininhibits skin lesions in imiquimod-induced psoriasis-like mice by downregulating inflammation
  6. Immunoregulatory Effects of PaeoniflorinExerts Anti-asthmatic Effects via Modulation of the Th1/Th2Equilibrium
  7. Oral administration of paeoniflorinattenuates allergic contact dermatitis by inhibiting dendritic cell migration and Th1 and Th17 differentiationin a mouse model
  8. Paeoniflorinsuppressesinflammatoryresponse in imiquimod-induced psoriasis-like mice and peripheral blood mononuclear cells (PBMCs) from psoriasis patients
  9. Comparative studies of paeoniflorinand albiflorin from Paeonia lactiflora on anti-inflammatoryactivities
  10. Paeoniflorininhibits function and down-regulates HLA-DR and CD80 expression of human peripheral blood monocytesstimulated by RhIL-1β
  11. Paeoniflorindown-regulates ATP-induced inflammatorycytokine productionand P2X7R expression on peripheral blood mononuclear cells from patients with primary Sjögren’s syndrome
  12. PaeoniflorinProtects against Ischemia-Induced Brain Damages in Rats via Inhibiting MAPKs/NF-κB-Mediated InflammatoryResponses
  13. PaeoniflorinAtttenuates Amyloidogenesis and the InflammatoryResponsesin a Transgenic Mouse Model of Alzheimer’s Disease
  14. PaeoniflorinAmeliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation
  15. Paeoniflorinsuppresses IL-6/Stat3 pathwayvia upregulation of Socs3 in dendritic cells in response to 1-chloro-2,4-dinitrobenze
  16. Paeoniflorindiminishes ConA-induced IL-8 productionin primary human hepatic sinusoidal endothelial cells in the involvement of ERK1/2 and Akt phosphorylation
  17. Paeoniflorinaugments systemic Candida albicans infection through inhibiting Th1 and Th17 cellexpression in a mouse model
  18. Paeoniflorinreduces neomycin-induced ototoxicity in hair cellsby suppression of reactive oxygen species generation and extracellularly regulated kinase signalization
  19. The Anti-InflammatoryEffectof Paeoniflorinon Cerebral Infarction Induced by Ischemia-Reperfusion Injury in Sprague-Dawley Rats
  20. Paeoniflorinprevents TLR2/4-mediated inflammationin type 2 diabetic nephropathy
  21. Partially purified paeoniflorinexerts protective effects on UV-induced DNA damage and reduces facial wrinkles in human skin.
  22. The skin‐depigmenting potential of Paeonia lactiflora root extract and paeoniflorin: in vitro evaluation using reconstructed pigmentedhuman epidermis
  23. BIOLOGICALLY ACTIVE PRINCIPLES OF CRUDE DRUGS. II. ANTI-ALLERGIC PRINCIPLES IN “SHOSEIRYU-TO” ANTI-INFLAMMATORYPROPERTIES OF PAEONIFLORINAND ITS DERIVATIVES
  24. Paeoniflorinimproves survival in LPS-challenged mice through the suppression of TNF-α and IL-1βrelease and augmentation of IL-10 production
  25. Effects of recombinant human interleukin-1βon functions of peripheral blood mononuclear cells from healthy adults and the role of paeoniflorin
  26. Paeoniflorinattenuates amyloid-beta peptide-induced neurotoxicity by ameliorating oxidative stressand regulating the NGF-mediated signaling in rats
  27. Protective effect of paeoniflorinagainst oxidative stressin human retinal pigment epithelium in vitro
  28. Paeoniflorinprotects against ANIT-induced cholestasis by ameliorating oxidative stressin rats
  29. Paeoniflorinameliorates rheumatoid arthritis in rat models through oxidative stress, inflammationand cyclooxygenase 2
  30. Inhibitory effect of paeoniflorinon methylglyoxal-mediated oxidative stressin osteoblastic MC3T3-E1 cells
  31. Effects of Paeoniflorin on Serum Levels of TNF-α、IL-6、IL-10 in Rat Hepatic Fibrosis Model
  32. Study of Blood Nourishing Effects of Albiflorin and Paeoniflorin on Blood Deficiency Mouse Model Induced by Irradiation of and Effect on Levels of IL-3,GM-CSF,IL-6and TNF-α
  33. Pharmacological effects of Paeoniflorin and Albiflorin on IL-3, GM-CSF, IL-6and TNF-α in the rats of syndrome of stagnation of liver qi and blood deficiency
  34. Paeoniflorin protects cells from GalN/TNF-α-induced apoptosis via ER stress and mitochondria-dependent pathways in human L02 hepatocytes
  35. [Comparative study on effects of blood enriching on mouse model of blood deficiency syndrome induced by cyclophosphamide of albiflorin, paeoniflorin on levels of GM-CSF, IL-3 and TNF-α].
  36. Paeoniflorin Antagonizes TNF-α-Induced L929 Fibroblastoma Cells Apoptosis by Inhibiting NF-κBp65 Activation
  37. Paeoniflorin alleviates TNF-αinduced intestinal barrier dysfunction by inhibition of MLCK
  38. [Inhibition of Paeoniflorin on TNF-α-induced TNF-α Receptor Type I /Nuclear Factor-κB Signal Transduction in Endothelial Cells].
  39. Influence of Paeoniflorin on Contents of Interleukin – 1β,Interleukin – 4 and TNF – α in Rats with Ulcerative Colitis
  40. Paeoniflorin induces the apoptosis of human gastric carcinoma cells by inhibiting activation of NF-κB
  41. Neuroprotection by Paeoniflorin against Nuclear Factor Kappa B-Induced Neuroinflammation on Spinal Cord Injury

  1. A WD-repeat-containing putative regulatory proteinin anthocyanin biosynthesis inPerilla frutescens
  2. Plant regeneration in vitro directly from cotyledon and hypocotyl explants ofPerilla frutescens and their morphological aspects
  3. STUDIES ON THE MORPHOLOGY,STRUCTURE AND DEVELOPMENT OF THE GLANDULAR HAIRS INPERILLA FRUTESCENS (L. )BRITTON
  4. MORPHOGENESIS OF GLANDULARHAIRSON THE LEAVES OFPERILLA FRUTESCENS (L. )BRITTON
  5. The promotion ofhair regrowthby topical application of a Perilla frutescens extractthrough increased cell viability and antagonism of testosterone and dihydrotestosterone
  6. Active Volatile Constituents inPerilla frutescensEssential Oils and Improvement ofAntimicrobial and Anti-InflammatoryBioactivityby Fractionation
  7. Identification and quantification of essential oil content and composition, total polyphenols andantioxidant capacityofPerilla frutescens (L.)Britt
  8. Purification and identification of two novelantioxidantpeptides from perilla (Perilla frutescens L.Britton) seed protein hydrolysates
  9. In Vitro and in VivoEffects of Macrophage-Stimulatory Polysaccharide fromLeaves of Perilla frutescensvar. crispa
  10. Effect ofPerilla frutescens var.acuta Kudo and rosmarinic acid on allergicinflammatoryreactions
  11. Biological evaluation of isoegomaketone isolated fromPerilla frutescensand its synthetic derivatives asanti-inflammatoryagents
  12. Anti-inflammatoryEffect of Perilla frutescens(L.) Britton var. frutescens Extract in LPS-stimulated RAW 264.7 Macrophages
  13. Anti‑inflammatory effects of Perilla frutescensleaf extract on lipopolysaccharide‑stimulated RAW264.7 cells
  14. Inhibition ofProinflammatory Cytokine Generationin Lung Inflammationby the Leaves ofPerilla frutescensand Its Constituents
  15. Perilla frutescens extractameliorates DSS-induced colitis bysuppressing proinflammatory cytokinesand inducing anti-inflammatorycytokines
  16. Phytochemical profiles and in vitro anti-inflammatoryproperties ofPerilla frutescenscv. Chookyoupjaso mutants induced by mutagenesis with γ-ray
  17. Perilla frutescens Leaf ExtractInhibits Mite Major Allergen Der p 2-induced Gene Expression of Pro-Allergic and Pro-Inflammatory Cytokinesin Human Bronchial Epithelial Cell BEAS-2B
  18. Anti-inflammatoryconstituents from Perilla frutescenson lipopolysaccharide-stimulated RAW264.7 cells
  19. Perilla frutescensExtracts Protects against Dextran Sulfate Sodium-Induced Murine Colitis: NF-κB, STAT3, and Nrf2 as Putative Targets
  20. Comparison ofanti-inflammatoryactivityof extracts with supercritical carbon dioxide from radiation mutant perilla frutescens(L.) Britton and wild-type
  21. Comparison of theAnti-Inflammatory Activitiesof Supercritical Carbon Dioxide versus Ethanol Extracts from Leaves ofPerilla frutescensBritt. Radiation Mutant
  22. Anti-inflammatoryActivity of Perilla frutescensBritton Seed in RAW 264.7 Macrophages and an Ulcerative Colitis Mouse Model
  23. Triterpene Acids from the Leaves ofPerilla frutescensand TheirAnti-inflammatoryand Antitumor-promoting Effects
  24. Rosmarinic acid inhibits epidermalinflammatory responses:anticarcinogenic effect ofPerilla frutescensextract in the murine two-stage skin model
  25. β-secretase (BACE1) inhibitors from Perilla frutescensvar. acuta
  26. Protective effect of aqueous extract ofPerilla frutescenson tert-butyl hydroperoxide-induced oxidative hepatotoxicity in rats
  27. The hepatoprotection of caffeic acid and rosmarinic acid, major compounds ofPerilla frutescens,against t-BHP-induced oxidative liver damage
  28. Ethanol Extract ofPerilla frutescens Suppresses Allergen-Specific Th2 Responsesand Alleviates Airway Inflammationand Hyperreactivity in Ovalbumin-Sensitized Murine Model of Asthma
  29. Anti-inflammatoryeffects of Perilla frutescensin activated human neutrophils through two independent pathways: Src family kinases and Calcium
  30. Hypolipidemic and antioxidant effects of total flavonoids ofPerilla Frutescens leaves in hyperlipidemiarats induced by high-fat diet
  31. Perilla Frutescens targets intestinal permeability
    In vitro study onTNF-α stress-induced barrier dysfunction in intestinal epithelial cells

  1. Pinocembrin attenuates gentamicin-induced nephrotoxicityin rats
  2. Pinocembrin attenuates blood–brain barrier injury induced by global cerebral ischemia–reperfusion in rats
  3. The characteristics of therapeutic effect of pinocembrin in transient global brain ischemia/reperfusion rats
  4. Use of racemates of pinocembrin in preparing medicaments for treating stroke
  5. In vitro and in vivo protection provided by pinocembrinagainst lipopolysaccharide-induced inflammatoryresponses
  6. Pinocembrin attenuates hippocampal inflammation, oxidative perturbations and apoptosis in a rat model of global cerebral ischemia reperfusion
  7. Pinocembrin protects hemorrhagic brainprimarily by inhibiting toll-like receptor 4 and reducing M1 phenotype microglia
  8. Protection of mice against lipopolysaccharide-induced endotoxic shock by pinocembrinis correlated with regulation of cytokine secretion
  9. Pinocembrin Protects Human BrainMicrovascular Endothelial Cells against Fibrillar Amyloid- β1−40 Injury by Suppressing the MAPK/NF- κ B InflammatoryPathways
  10. Pinocembrin Inhibits Matrix MetalloproteinaseExpression in Chondrocytes
  11. Pinocembrin attenuates lipopolysaccharide-induced inflammatoryresponsesin Labeo rohita macrophages via the suppression of the NF-κB signalling pathway
  12. Pinocembrin,a novel histidine decarboxylase inhibitor with anti-allergic potentialin in vitro
  13. Pinocembrin inhibits lipopolysaccharide-induced inflammatorymediatorsproduction in BV2 microglial cells through suppression of PI3K/Akt/NF-κB pathway
  14. Pinocembrin– flavonoid component of domestic propolis with delaying effect of the development of Alzheimer’s disease
  15. Pinocembrin improves cognitionand protects the neurovascular unit in Alzheimer related deficits
  16. THERAPEUTIC EFFECTS OF PINOCEMBRINON INDOMETHACIN-INDUCED GASTRIC ULCER MODEL IN RATS
  17. Pinocembrin protects brain against ischemia/reperfusion injury by attenuating endoplasmic reticulum stress induced apoptosis
  18. Protections of pinocembrin on brain mitochondriacontribute to cognitive improvement in chronic cerebral hypoperfused rats
  19. Pinocembrin Attenuates 6-OHDA-induced Neuronal CellDeath Through Nrf2/ARE Pathway in SH-SY5Y Cells
  20. Inhibition of beta-amyloid-induced neurotoxicity by pinocembrin through Nrf2/HO-1 pathwayin SH-SY5Y cells
  21. Pinocembrin protects rat brain against oxidationand apoptosis induced by ischemia–reperfusion both in vivo and in vitro
  22. Pinocembrin Protects SH-SY5Y Cells Against MPP+-Induced Neurotoxicity Through the Mitochondrial Apoptotic Pathway
  23. Pinocembrin reduces cardiac arrhythmiaand infarct size in rats subjected to acute myocardial ischemia/reperfusion
  24. Pinocembrin protects against β-amyloid-induced toxicityin neurons through inhibiting receptor for advanced glycation end products (RAGE)-independent signaling pathways and regulating mitochondrion-mediated apoptosis
  25. Pinocembrin attenuates MPP+-induced neurotoxicityby the induction of heme oxygenase-1 through ERK1/2 pathway
  26. Galangin and Pinocembrin from Propolis Ameliorate Insulin Resistancein HepG2 Cells via Regulating Akt/mTORSignaling
  27. Neuroprotective effects of pinocembrinon ischemia/reperfusion-induced brain injury by inhibiting autophagy
  28. Pinocembrin induces ER stress mediated apoptosisand suppresses autophagyin melanoma cells
  29. Pinocembrin Protects the Brain against Ischemia-Reperfusion Injuryand Reverses the AutophagyDysfunction in the Penumbra Area
  30. Antiproliferative and apoptotic effects of pinocembrinin human prostate cancer cells

  1. Leishmanicidal Activity of Piper nigrumBioactive Fractions is Interceded via Apoptosis In Vitro and Substantiated by Th1 Immunostimulatory PotentialIn Vivo
  2. Piper nigrum extractameliorated allergic inflammationthrough inhibiting Th2/Th17 responsesand mast cells activation
  3. Anti-inflammatoryactivityand chemical composition of dichloromethane extract from Piper nigrumand P. longum on permanent focal cerebral ischemia injury in rats
  4. Piperineinhibits cytokine productionby human peripheral blood mononuclear cells
  5. Piperineis a potent inhibitor of nuclear factor-κB (NF-κB), c-Fos, CREB, ATF-2 and proinflammatory cytokinegene expression in B16F-10 melanoma cells
  6. Alkaloids from Piper nigrumExhibit AntiinflammatoryActivity via Activating the Nrf2/HO­1 Pathway
  7. Piperine inhibits IL-β inducedexpression of inflammatorymediators in human osteoarthritis chondrocyte
  8. Piper nigrumFruit Extract Prevents TMA-Induced Allergic Contact Dermatitis by Regulating Th2 CytokineProduction
  9. Melanogenesis Stimulation in Murine B16 Melanoma Cellsby Piper nigrumLeaf Extract and Its Lignan Constituents
  10. Alkamides from Piper longum and Piper nigrumas Inhibitors of IL-6action
  11. Antioxidant efficacy of black pepper (Piper nigrum L.)and piperine in rats with high fat diet induced oxidative stress
  12. Methanolic Extract of Piper nigrumFruits Improves Memory Impairment by Decreasing Brain Oxidative Stressin Amyloid Beta(1–42) Rat Model of Alzheimer’s Disease
  13. Piper nigrumethanolic extract rich in piperamides causes ROS overproduction, oxidative damagein DNA leading to cell cycle arrest and apoptosis in cancer cells
  14. γ-Aminobutyric acid (GABA) priming enhances the osmotic stresstolerance in Piper nigrum Linn.plants subjected to PEG-induced stress
  15. Antioxidant, Anti-inflammatoryand Antinociceptive Properties of Black Pepper Essential Oil (Piper nigrum Linn)
  16. Polyphenolic extract of Piper nigrum inhibitssodium oxalate induced oxidative stressin rat kidney
  17. Analgesic and anti-inflammatoryactivities of Piper nigrum L.
  18. Piperineand quercetin enhances antioxidant and hepatoprotective effect of curcumin in paracetamol induced oxidative stress
  19. Piperinemodulation of carcinogen induced oxidative stressin intestinal mucosa
  20. Modulation of cadmium induced alterations in murine thymocytes by piperine: Oxidative stress,apoptosis, phenotyping and blastogenesis
  21. Piperineameliorates oxidative stress, inflammationand histological outcome in collagen induced arthritis
  22. Piperinepotentiates the protective effects of curcumin against chronic unpredictable stress-induced cognitive impairment and oxidative damagein mice
  23. Attenuation of beryllium induced hepatorenal dysfunction and oxidative stressin rodents by combined effect of gallic acid and piperine
  24. Quercetin along with piperineprevents cognitive dysfunction, oxidative stressand neuro-inflammationassociated with mouse model of chronic unpredictable stress
  25. The use of nitroxide radical-containing nanoparticles coupled with piperineto protect neuroblastoma SH-SY5Y cells from Aβ-induced oxidative stress
  26. Piperineinhibits eosinophil infiltration and airway hyperresponsiveness by suppressing T cell activity and Th2 cytokine productionin the ovalbumin‐induced asthma model
  27. Caloric restriction favorably impacts metabolic and immune/inflammatory profilesin obese mice but curcumin/piperineconsumption adds no further benefit
  28. Piperinesuppresses cerebral ischemia–reperfusion-induced inflammationthrough the repression of COX-2, NOS-2, and NF-κB in middle cerebral artery occlusion rat model
  29. Anti-apoptotic and Anti-inflammatoryeffect of Piperineon 6-OHDA induced Parkinson’s Rat model
  30. Anti‐Inflammatory Effectsof Capsaicin and Piperineon Helicobacter pylori‐Induced Chronic Gastritis in Mongolian Gerbils
  31. Inhibitory Effects of Black Pepper (Piper Nigrum) Extracts and Compounds on Human Tumor Cell Proliferation, Cyclooxygenase Enzymes, Lipid Peroxidation and Nuclear Transcription Factor-kappa-B

  1. Studies of the Active Substances in Herbs Used for Hair Treatment. II.Isolation of Hair RegrowthSubstances,Acetosyringone and Polyporusterone A and B, from Polyporus umbellatusFries
  2. Studies on Active Substances in Herbs Used for Hair Treatment.I. Effects of Herb Extracts on Hair Growthand Isolation of an Active Substance from Polyporus umbellatus F.
  3. Traditional uses, phytochemistry, pharmacology, pharmacokinetics and quality control of Polyporus umbellatus (Pers.)Fries: A review
  4. Studies of Active Substances in Herbs Used for Hair Treatment. IV. The Structure of the Hair RegrowthSubstance, Polyporusterone A, from Polyporus umbellatus F.
  5. Diuretic activityand kidney medulla AQP1, AQP2, AQP3, V2R expression of the aqueous extract of sclerotia of Polyporus umbellatusFRIES in normal rats
  6. Inhibitory Effects of Triterpenes Isolated from Chuling (Polyporus umbellatus FRIES)on Free Radical-Induced Lysisof Red Blood Cells
  7. Polyporus umbellatus,an Edible-Medicinal Cultivated Mushroom with Multiple Developed Health-Care Products as Food, Medicine and Cosmetics: A Review
  8. Fungal species residing in the sclerotia of Polyporus umbellatus
  9. Renoprotective effectand mechanism of polysaccharide from Polyporus umbellatussclerotia on renal fibrosis
  10. TLR4-mediated activation of macrophagesby the polysaccharide fraction from Polyporus umbellatus(pers.)Fries
  11. Polysaccharide purified from Polyporus umbellatus(Per) Fr induces the activation and maturation of murine bone-derived dendritic cells via toll-like receptor 4
  12. Polyporus umbellatus,an Edible-Medicinal Cultivated Mushroom with Multiple Developed Health-Care Products as Food,Medicine and Cosmetics: A Review
  13. Nutritional factors determining sclerotial formation of Polyporus umbellatus
  14. Determination of optimal carbon source and pH value for sclerotial formation of Polyporus umbellatusunder artificial conditions
  15. GrowthPromoting Effectsof Water Extract of Armillaria mellea Rhizomorph on Myceliaof Polyporus umbellatus
  16. Nox Gene Expression and Cytochemical Localization of Hydrogen Peroxide in Polyporus umbellatusSclerotial Formation
  17. Induction of apoptosisin MCF‑7 human breast cancer cells by Khz (fusion of Ganoderma lucidum and Polyporus umbellatus mycelium)
  18. New anti-inflammatoryergostane-type ecdysteroids from the sclerotium of Polyporus umbellatus
  19. Cytotoxic Steroids from Polyporus umbellatus
  20. Polyporus umbellatuspolysaccharidesameliorates carbon tetrachloride-induced hepatic injury in mice
  21. Structure and chain conformation of a neutral polysaccharide from sclerotia of Polyporus umbellatus
  22. Bioactivity-directed isolation, identification of diuretic compounds from Polyporus umbellatus
  23. Ergosta‐4,6,8(14),22‐tetraen‐3‐one isolated from Polyporus umbellatusprevents early renal injury in aristolochic acid‐induced nephropathy rats
  24. Polyporus umbellatus inhibited tumor cellproliferation and promoted tumor cell apoptosis by down-regulating AKT in breast cancer
  25. Genetic Diversity and Evolution of Chinese Traditional Medicinal Fungus Polyporus umbellatus(Polyporales, Basidiomycota)
  26. Khz (Fusion Product of Ganoderma lucidum and Polyporus umbellatus Mycelia)Induces Apoptosis in Human Colon CarcinomaHCT116 Cells, Accompanied by an Increase in Reactive Oxygen Species, Activation of Caspase 3, and Increased Intracellular Ca2+
  27. Simultaneous determination of eight major steroids from Polyporus umbellatusby high‐performance liquidchromatography coupled with mass spectrometry detections
  28. DETERMINATION OF MUSHROOM MONOSACCHARIDES BY LIQUID CHROMATOGRAPHY MASS-SPECTROMETRY (LCMS) AND MACROPHAGE ACTIVATIONBY POLYSACCHARIDES FROM Polyporus umbellatus,Fuscoporia obliqua, Cordyceps militaris AND Pleurotus ostreatus
  29. GPP (Composition of Ganoderma Lucidum Poly-saccharides and Polyporus UmbellatusPoly-saccharides) Enhances Innate Immune Function in Mice
  30. Transcriptome analysis of genes involved in defence response in Polyporus umbellatuswith Armillaria mellea infection
  31. The Study of Polyporus Umbellatus Polysaccharide Effecting on Expressions of Mouse HepA Tumor Cell P16? Rb Gene and TNF-α [J]
  32. Study of Effect of Polyporus Umbellatus and Alisma Orientalis on TGF-β_1 and TNF-α in Serum of Pulmonary Fibrosis Rat Model

  1. Polyphenol-rich extract of pomegranatepeel alleviates tissue inflammationand hypercholesterolaemia in high-fat diet-induced obese mice: potential implication of the gut microbiota
  2. Polyphenol-rich pomegranate fruitextract (POMx) suppresses PMACI-induced expression of pro-inflammatory cytokinesby inhibiting the activation of MAP Kinases and NF-κB in human KU812 cells
  3. Effects of pomegranatejuice in circulating parameters, cytokines, and oxidative stressmarkers in endurance-based athletes: A randomized controlled trial
  4. Potential Anti-InflammatoryEffectsof the Hydrophilic Fraction of Pomegranate(Punica granatum L.) Seed Oil on Breast Cancer Cell Lines
  5. Effects of pomegranatejuice consumption oninflammatorymarkers in patients with type 2 diabetes: A randomized, placebo-controlled trial
  6. Dietary supplementation of an ellagic acid-enriched pomegranateextract attenuates chronic colonic inflammationin rats
  7. The Effects of Pomegranate Juiceon ProinflammatoryCytokines and Physical Function in Patients With Knee Osteoarthritis
  8. Pomegranateextract alleviates disease activity and some blood biomarkers of inflammationand oxidative stressin Rheumatoid Arthritis patients
  9. Potential Effects of Pomegranateon Lipid Peroxidation and Pro-inflammatoryChanges in Daunorubicin-induced Cardiotoxicity in Rats
  10. Anti-InflammatoryMechanism Involved in Pomegranate-Mediated Prevention of Breast Cancer: the Role of NF-κB and Nrf2 Signaling Pathways
  11. Polyphenolics from Mango (Mangifera indica L.) and Pomegranate(Punica granatum L.) Suppress Inflammationin in vivo and in vitro Models for Colitis
  12. Does Short Term Usage of Fresh PomegranateJuice (FPJ) Protect Cochlear Hair Cellsafter Cisplatin-Based Chemo-Irradiation?
  13. Hair-dyeing by using Pomegranate Hull Extract
  14. Pomegranateseed oil nanoemulsions improve the photostability and in vivo antinociceptive effect of a non-steroidal anti-inflammatorydrug
  15. Anthocyanin‐ and hydrolyzable tannin‐rich pomegranatefruit extract modulates MAPK and NF‐κB pathways and inhibits skin tumorigenesisin CD‐1 mice
  16. Protective effect of pomegranate‐derived products on UVB‐mediated damage in human reconstituted skin
  17. Protective Effects of Standardized Pomegranate(Punica granatum L.) Polyphenolic Extract in Ultraviolet-Irradiated Human SkinFibroblasts
  18. Phenolic Compounds of PomegranateByproducts (Outer Skin, Mesocarp, Divider Membrane) and Their Antioxidant Activities
  19. Pomegranate FruitExtract Inhibits UVB‐induced Inflammationand Proliferation by Modulating NF‐κB and MAPK Signaling Pathways in Mouse Skin
  20. Thermal characteristics of a water soluble extract obtained from pomegranateskin: Developing a state diagram for determining stability
  21. Synergistic growthinhibition of mouse skin tumorsby pomegranatefruit extract and diallyl sulfide: Evidence for inhibition of activated MAPKs/NF-κB and reduced cell proliferation
  22. Pomegranatejuice consumption reduces oxidative stress,atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E–deficient mice
  23. Beneficial effects of pomegranatejuice on oxidation-sensitivegenes and endothelial nitric oxide synthase activity at sites of perturbed shear stress
  24. Anti-oxidative effectsof pomegranatejuice (PJ) consumption by diabetic patients on serum and on macrophages
  25. Pomegranatereverses methotrexate-induced oxidative stressand apoptosis in hepatocytes by modulating Nrf2-NF-κB pathways
  26. PomegranateByproduct Administration to Apolipoprotein E-Deficient Mice Attenuates Atherosclerosis Development as a Result of Decreased Macrophage Oxidative Stressand Reduced Cellular Uptake of Oxidized Low-Density Lipoprotein
  27. One year of pomegranatejuice intake decreases oxidative stress, inflammation,and incidence of infections in hemodialysis patients: A randomized placebo-controlled trial
  28. Pomegranatejuice exacerbates oxidative stressand nigrostriatal degeneration in Parkinson’s disease
  29. Pomegranatejuice and punicalagin attenuate oxidative stressand apoptosis in human placenta and in human placental trophoblasts
  30. Effects of a Pomegranate Fruit Extract rich in punicalagin on oxidation-sensitive genesand eNOS activity at sites of perturbed shear stress and atherogenesis
  31. Effect of pomegranate seed oil on serum TNF-α level in dyslipidemic patients
  32. Pomegranate extract prevents skeletal muscle of mice against wasting induced by acute TNF‐α injection
  33. The effects of pomegranate seed oil supplementation on the PPAR gamma and GLUT4 genes expression and the serum levels of IL-6, TNF-α and hs-CRP inflammatory factors and Glycemic indexes in obese type 2 diabetic patients: randomized controlled clinical trial
  34. A Polyphenol‐rich Pomegranate Fruit Extract Suppresses NF‐κB and IL‐6 Expression by Blocking the Activation of IKKβ and NIK in Primary Human Chondrocytes
  35. THE EFFECT OF SIX WEEKS AEROBIC EXERCISE AND POMEGRANATE JUICE CONSUMPTION ON IL-6IN WOMEN WHIT TYPE 2 DIABETIC
  36. Pomegranate Fruit Extract Modulates UV‐B–mediated Phosphorylation of Mitogen‐activated Protein Kinases and Activation of Nuclear Factor Kappa B in Normal Human Epidermal Keratinocytes
  37. Pomegranate fruit extract modulates UVB-induced activation of nuclear factor kappa B and phosphorylation of mitogen activated protein kinases in normal human epidermal keratinocytes
  38. 137: Evaluation of Pomegranate Polyphenol-Mediated Suppression of Nuclear Factor Kappa b (NF-KB) Activity in Prostate Cancer Cell Lines

  1. Oral administration of apple condensed tanninsdelays rheumatoid arthritis development in mice via downregulation of T helper 17 (Th17) cell responses
  2. Oligomeric ProcyanidinsInterfere with Glycolysis of Activated T Cells. A Novel Mechanism for Inhibition of T Cell Function
  3. Grape-seed procyanidinsprevent low-grade inflammationby modulating cytokine expressionin rats fed a high-fat diet
  4. Cocoa Procyanidinsand Human CytokineTranscription and Secretion
  5. Effect of Cocoa Procyanidinson the Secretion of Interleukin-4in Peripheral Blood Mononuclear Cells
  6. The in vitro evaluation of isolated procyanidinsas modulators of cytokine-inducedeotaxin production in human alveolar epithelial cells
  7. Oral Administration of Apple ProcyanidinsAmeliorates Insulin Resistance via Suppression of Pro-InflammatoryCytokine Expression in Liver of Diabetic ob/ob Mice
  8. Anti-InflammatoryProcyanidinsand Triterpenes in 109 Apple Varieties
  9. Dietary Grape-Seed ProcyanidinsDecreased Postweaning Diarrhea by Modulating Intestinal Permeability and Suppressing Oxidative Stressin Rats
  10. Grape-Seed ProcyanidinsAct as AntiinflammatoryAgents in Endotoxin-Stimulated RAW 264.7 Macrophages by Inhibiting NFkB Signaling Pathway
  11. Effects of Grape Seed Procyanidinson Cytokines,Nitric Oxide Synthaseand Blood-Brain Barrier After Cerebral Ischemia-Reperfusion in Mice
  12. Procyanidin B2gallates inhibit IFN-γ and IL-17productionin T cells by suppressing T-bet and RORγt expression
  13. Multiple Cytokine Inhibitionthrough Specific Procyanidin–EnrichedPlant Extracts: Implicationsfor the Treatment of Psoriasis, Eczema and Dermatitis
  14. Contribution of transcript stability to a conserved procyanidin-inducedcytokine responsein γδ T cells
  15. Chemical Characterization of a Procyanidin-Rich Extract from Sorghum Bran and Its Effect on Oxidative Stressand Tumor Inhibition in Vivo
  16. ProcyanidinB2 Protects Neurons from Oxidative, Nitrosative, and Excitotoxic Stress
  17. Antigenotoxic Effect of Grape Seed ProcyanidinExtract in Fao Cells Submitted to Oxidative Stress
  18. Protective effects of grape seed procyanidin extractagainst nickel sulfate-induced apoptosis and oxidative stressin rat testes
  19. Protective effects of oligomeric and polymeric procyanidinfractions from defatted grape seeds on tert-butyl hydroperoxide-induced oxidative damagein HepG2 cells
  20. Cocoa procyanidinchain length does not determine ability to protect LDL from oxidationwhen monomer units are controlled
  21. Critical Role of FoxO1 in Granulosa Cell Apoptosis Caused by Oxidative Stressand Protective Effects of Grape Seed ProcyanidinB2
  22. The protective effect of grape seed procyanidin extractagainst cadmium-induced renal oxidative damagein mice
  23. Grape seed procyanidinextract attenuates hypoxic pulmonary hypertension by inhibiting oxidative stressand pulmonary arterial smooth muscle cells proliferation
  24. The Antioxidant ProcyanidinReduces Reactive Oxygen Species Signaling in Macrophages and Ameliorates Experimental Colitis in Mice
  25. ProcyanidinB2 3,3″‐di‐O‐gallate induces oxidative stress‐mediated cell death in prostate cancer cells via inhibiting MAP kinase phosphatase activity and activating ERK1/2 and AMPK
  26. Procyanidinsfrom Vitis vinifera Seeds:  In Vivo Effects on Oxidative Stress
  27. Procyanidindimer B1 and trimer C1 impair inflammatoryresponsesignalling in human monocytes
  28. Anti-inflammatoryeffectsof grape seed procyanidinB2 on a diabetic pancreas
  29. Synthesis of ProcyanidinB3 and Its Anti-inflammatoryActivity. The Effect of 4-Alkoxy Group of Catechin Electrophile in the Yb(OTf)3-Catalyzed Condensation with Catechin Nucleophile
  30. Anti-inflammatoryeffectof procyanidinB1 on LPS-treated THP1 cells via interaction with the TLR4–MD-2 heterodimer and p38 MAPK and NF-κB signaling
  31. Effect of Procyanidins on DOMS and Blood Plasma IL-6in College Athletes
  32. Modulation of TNF-α Secretion in Peripheral Blood Mononuclear Cells by Cocoa Flavanols and Procyanidins
  33. Effects of Hawthorn Leaf Procyanidins on Over Expressions of ICAM-1 and E-selectin in Human Umbilical Vein Endothelial Cells Induced by TNF-α

  1. Diverse role of fast growing rhizobia in growthpromotionand enhancement of psoralen content in Psoralea corylifolia L
  2. Phytopharmacological assessment of medicinal properties of Psoralea corylifolia
  3. ANTIMICROBIAL ACTIVITYOF LEAF EXTRACT OF PSORALEA CORYLIFOLIA L
  4. Polyphenols Displaying Tyrosinase Inhibition from the Seed of Psoralea corylifolia
  5. Mechanism of Cytotoxicity by Psoralea corylifolia Extractin Human Breast Carcinoma Cells
  6. In vitro enhancement of psoralen as an important anticancer compoundin Psoralea corylifoliathrough precursor feeding
  7. Psoralea corylifolia l. an endangered medicinal plant with broad spectrum properties
  8. Preliminary Phytochemical Studies and Evaluation of Antibacterial Activity of Psoralea corylifoliaSeed Extract
  9. Phytochemical Screening and Antibacterial Potentialityof Essential Oil from Psoralea corylifoliaLinn
  10. ANTIMICROBIAL AND ANTIOXIDANT SYNERGY OF PSORALEA CORYLIFOLIALINNANDPLUMBAGOZEYLANICALINN.
  11. Dietary Total Prenylflavonoids from the Fruits of Psoralea corylifolia L. Prevents Age-Related Cognitive Deficits and Down-Regulates Alzheimer’s Markersin SAMP8 Mice
  12. Antimicrobial activity in fruit extract of Psoralea corylifoliaL. on pathogenic organisms
  13. Phenolic Compounds Isolated from Psoralea corylifolia Inhibit IL-6-induced STAT3 Activation
  14. Bavachin from Psoralea corylifolia Improves Insulin-Dependent Glucose Uptake through Insulin Signaling and AMPKActivation in 3T3-L1 Adipocytes
  15. The ethanol extraction of prepared Psoralea corylifolia induces apoptosisand autophagyand alteres genes expression assayed by cDNA microarray in human prostate cancer PC‐3 cells
  16. Compounds isolated from Psoralea corylifoliaseeds inhibit protein kinase activity and induce apoptotic celldeath in mammalian cells
  17. Characterization of Compounds in Psoralea corylifoliaUsing High-Performance Liquid Chromatography Diode Array Detection, Time-of-Flight Mass Spectrometry and Quadrupole Ion Trap Mass Spectrometry
  18. Psoralea corylifolia LAttenuates Nonalcoholic Steatohepatitisin Juvenile Mouse
  19. Prenylated flavonoid‐standardized extract from seeds of Psoralea corylifolia Lactivated fat browning in high‐fatdiet–induced obese mice
  20. Psoralea corylifolia extracts stimulate cholinergic-like psoralen receptors of tadpole-tail melanophores, leading to skin darkening
  21. Fabrication of anti-vitiligo ointmentcontaining Psoralea corylifolia: in vitro and in vivo characterization
  22. Protective effects of the compounds isolated from the seed of Psoralea corylifolia on oxidative stress-induced retinal damage
  23. Psoralea corylifolia LSeed Extract Ameliorates Streptozotocin-Induced Diabetes in Miceby Inhibition of Oxidative Stress
  24. Anti-oxidant modulation in response to gamma radiation induced oxidative stressin developing seedlings of Psoralea corylifolia L
  25. Protective Role of Psoralea corylifolia LSeed Extract against Hepatic Mitochondrial Dysfunction Induced by Oxidative Stress or Aging
  26. In Vivo Anti-diabetic and Anti-oxidant Potential of Psoralea corylifoliaSeeds in Streptozotocin Induced Type-2 Diabetic Rats
  27. Neuroprotective effects of Psoralea corylifolia Linnseed extracts on mitochondrial dysfunction induced by 3-nitropropionic acid
  28. Prenylflavones from Psoralea corylifolia Inhibit Nitric Oxide Synthase Expressionthrough the Inhibition of I-κB-α Degradation in Activated Microglial Cells
  29. Protective Effect of Psoralea corylifolia LSeed Extract against Palmitate-Induced Neuronal Apoptosisin PC12 Cells
  30. Quantitative Analysis of Psoralea corylifolia Linneand its Neuroprotective and Anti-Neuroinflammatory Effectsin HT22 Hippocampal Cells and BV-2 Microglia

    1. Pterostilbenesurpassed resveratrol for anti-inflammatoryapplication: Potency consideration and pharmacokinetics perspective
    2. Anti-inflammatoryAction of PterostilbeneIs Mediated through the p38 Mitogen-Activated Protein Kinase Pathway in Colon Cancer Cells
    3. Effects of polyphenols including curcuminoids, resveratrol, quercetin, pterostilbene, and hydroxypterostilbene on lymphocyte pro-inflammatory cytokine productionof senior horses in vitro
    4. Pterostilbeneexerts an anti-inflammatoryeffectvia regulating endoplasmic reticulum stress in endothelial cells
    5. Effect of resveratrol and pterostilbeneon aging and longevity
    6. Pterostilbeneattenuates theinflammatoryreaction induced by ischemia/reperfusion in rat heart
    7. The Inhibitory Effect of Pterostilbeneon InflammatoryResponsesduring the Interaction of 3T3-L1 Adipocytes and RAW 264.7 Macrophages
    8. Pterostilbeneinhibits inflammationand ROS production in chondrocytes by activating Nrf2 pathway
    9. Pharmacometrics of pterostilbene: preclinical pharmacokinetics and metabolism, anticancer, antiinflammatory, antioxidant and analgesic activity
    10. Pterostilbeneand allopurinol reduce fructose-induced podocyte oxidative stressand inflammationvia microRNA-377
    11. SIRT1activation by pterostilbeneattenuates the skeletal muscle oxidative stressinjury and mitochondrial dysfunction induced by ischemia reperfusion injury
    12. Blueberry Component PterostilbeneProtects Corneal Epithelial Cells from Inflammationvia Anti-oxidative Pathway
    13. Protective effect of Pterostilbeneagainst free radical mediated oxidative damage
    14. Pterostilbeneprotects against myocardial ischemia/reperfusion injury via suppressing oxidative/nitrative stress and inflammatoryresponse
    15. Pterostilbenereduces oxidative stress,prevents hypertrophy and preserves systolic function of right ventricle in cor pulmonale model
    16. Topical treatment with pterostilbene, a natural phytoalexin, effectively protects hairless mice against UVB radiation-induced skin damageand carcinogenesis
  1. Pterostilbeneameliorates insulin sensitivity, glycemic control and oxidative stressin fructose-fed diabetic rats
  2. Pterostilbeneattenuates high glucose-induced oxidative injuryin hippocampal neuronal cells by activating nuclear factor erythroid 2-related factor 2
  3. Evidence for oxidative detoxicationof pterostilbeneand resveratrol by a laccase-like stilbene oxidase produced by Botrytis cinerea
  4. Pterostilbene, a natural dimethylated analog of resveratrol, inhibits rat aortic vascular smooth muscle cell proliferation by blocking Akt-dependent pathway
  5. Pterostilbene suppresses vascular adhesion molecule expression in TNF-α-stimulated vascular muscle cells
  6. Resveratrol and pterostilbene inhibit TNF-α stimulated activation of NF-kB and its upstream TAK1 in macrophages via modulation of sphingolipids

  1. Quercetinsuppresses proinflammatory cytokinesproduction through MAP kinases and NF-κB pathway in lipopolysaccharide-stimulated macrophage
  2. Effects of the wine polyphenolics quercetinand resveratrol on pro-inflammatory cytokine expressionin RAW 264.7 macrophages
  3. The Flavonoid QuercetinInhibits Proinflammatory Cytokine(Tumor Necrosis Factor Alpha) Gene Expression in Normal Peripheral Blood Mononuclear Cells via Modulation of the NF-κβ System
  4. Quercetininhibits expression of inflammatorycytokinesthrough attenuation of NF-κB and p38 MAPK in HMC-1 human mast cell line
  5. Quercetin Reduces Inflammatory Pain: Inhibition of Oxidative Stressand Cytokine Production
  6. QuercetinIngestion Does Not Alter Cytokine Changesin Athletes Competing in the Western States Endurance Run
  7. A comparison of the effects of kaempferol and quercetinon cytokine-induced pro-inflammatorystatus of cultured human endothelial cells
  8. The flavonoid, quercetin, differentially regulates Th-1 (IFNγ) and Th-2 (IL4) cytokinegene expression by normal peripheral blood mononuclear cells
  9. Quercetininhibits UV irradiation-induced inflammatory cytokine productionin primary human keratinocytes by suppressing NF-κB pathway
  10. QuercetinIs More Effective than Cromolyn in Blocking Human Mast Cell Cytokine Releaseand Inhibits Contact Dermatitis and Photosensitivity in Humans
  11. Quercetinattenuates collagen-induced arthritis by restoration of Th17/Treg balanceand activation of Heme Oxygenase 1-mediated anti-inflammatoryeffect
  12. Quercetinprotects mouse liver against triptolide-induced hepatic injury by restoring Th17/Treg balancethrough Tim-3 and TLR4-MyD88-NF-κB pathway
  13. Quercetin Inhibits InflammatoryBone Resorption in a Mouse Periodontitis Model
  14. Tannic acid and quercetindisplay a therapeutic effect on atopic dermatitisvia suppression of angiogenesis and Th2 polarization. (97.7)
  15. Protective role of quercetinagainst cisplatin-induced hair cell damagein zebrafish embryos
  16. INHIBITION BY QUERCETINOF THE PROMOTING EFFECT OF TELEOCIDIN ON SKIN PAPILLOMA FORMATION IN MICE INITIATED WITH 7, 12-DIMETHYLBENZ[a]ANTHRACENE
  17. Quercetinprotects against hair cell lossin the zebrafish lateral line and guinea pig cochlea
  18. Quercetin, Inflammationand Immunity
  19. The Inhibitory Effect of Quercetin on IL-6Productionby LPS- Stimulated Neutrophils
  20. Quercetinameliorates imiquimod-induced psoriasis-like skin inflammationin mice via the NF-κB pathway
  21. Quercetin abrogates IL-6/STAT3signaling and inhibits glioblastoma cell line growthand migration
  22. Quercetin inhibits IL-1 beta-induced ICAM-1 expression in pulmonary epithelial cell line A549 through the MAPK pathways
  23. Quercetin regulates Th1/Th2 balancein a murine model of asthma
  24. In vivo quercitrin anti‐inflammatory effectinvolves release of quercetin, which inhibits inflammationthrough down‐regulation of the NF‐κB pathway
  25. Quercetin Inhibits IL-1β-InducedProliferation and Production of MMPs, COX-2, and PGE2 by Rheumatoid Synovial Fibroblast
  26. Anti-inflammatoryactivityof quercetinand isoquercitrin in experimental murine allergic asthma
  27. Quercetin3-O-β-(2″-galloyl)-glucopyranoside inhibits endotoxin LPS-induced IL-6expressionand NF-κB activation in macrophages
  28. Regulation of IL‐1‐induced selective IL‐6 releasefrom human mast cells and inhibition by quercetin
  29. QuercetinDown-regulates IL-6/STAT-3Signals to Induce Mitochondrial-mediated Apoptosis in a Nonsmall- cell Lung-cancer Cell Line, A549
  30. Regulatory mechanisms of IL-2and IFNγ suppression by quercetinin T helper cells
  31. Quercetin, a bioflavonoid, accelerates TNF-α-induced growth inhibition and apoptosis in MC3T3-E1 osteoblastic cells
  32. Quercetin accelerates TNF-α-induced apoptosis of MC3T3-E1 osteoblastic cells through caspase-dependent and JNK-mediated pathways
  33. Effect of apoE genotype and dietary quercetin on blood lipids and TNF-α levels in apoE3 and apoE4 targeted gene replacement mice
  34. Quercetin-3-O-(2″-galloyl)-α-l-rhamnopyranoside inhibits TNF-α-activated NF-κB-induced inflammatory mediator production by suppressing ERK activation
  35. Human Quercetin Conjugated Metabolites Attenuate TNF-α-induced Changes in Vasomodulatory Molecules in an HUASMCs/HUVECs Co-culture Model
  36. Effects of Quercetin in IL-6and TNF-αLevels in Diabetic Rats
  37. Anti-inflammatory property of quercetin through downregulation of ICAM-1 and MMP-9 in TNF-α-activated retinal pigment epithelial cells
  38. The inhibitory effects of the flavonoid quercetin on endotoxin (LPS)-stimulated production of tumor necrosis factor-α (TNF-α) by normal human peripheral blood mononuclear cells (PBMC)
  39. Regulation of IL‐1‐induced selective IL‐6 release from human mast cells and inhibition by quercetin
  40. Quercetin inhibits the poly(dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-γ-primed human keratinocytes
  41. Quercetin inhibits IL-1β induced ICAM-1 expression in human alveolar epithelial cells.
  42. PENGARUH QUERCETIN TERHADAP KADAR INTERLEUKIN-1 (IL-1) TIKUS YANG DIINDUKSI OBAT ANTI TUBERKULOSI
  43. Quercetin inhibits epithelial–mesenchymal transition, decreases invasiveness and metastasis, and reverses IL-6induced epithelial–mesenchymal transition, expression of MMP by inhibiting STAT3 signaling in pancreatic cancer cells
  44. Inhibitory effects of quercetin on LPS–stimulated IL–6 production by neutrophils
  45. Effects of Quercetin on Muscle Function during IL-6-induced Cancer Cachexia
  46. EFFECT OF QUERCETIN ON STRESS INDUCED CHANGES IN INTERLEUKIN 6 (IL-6) LEVELS IN ALBINO RATS.
  47. QUERCETIN INHIBITS IL-6/JAK/STAT3 SIGNALLING PATHWAY IN LIVER OF RATS WITH CIRRHOSIS INDUCED BY COMMON BILE DUCT LIGATION
  48. Inhibitory mechanism of quercetin 3-0-beta -(2 “-galloyI )-glucopyranoside on IL-6expression in LPS -stimulated macrophages RAW 264 .7
  49. Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IκB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia
  50. Quercetin suppresses inflammation by reducing ERK1/2 phosphorylation and NF kappa B activation in Leptin-induced Human Umbilical Vein Endothelial Cells (HUVECs)
  51. Quercetin induces human colon cancer cells apoptosis by inhibiting the nuclear factor-kappa B Pathway
  52. Quercetin Suppresses the Migration and Invasion in Human Colon Cancer Caco-2 Cells Through Regulating Toll-like Receptor 4/Nuclear Factor-kappa B Pathway
  53. Quercetin Protects Mice from ConA-Induced Hepatitis by Inhibiting HMGB1-TLR Expression and Down-Regulating the Nuclear Factor Kappa B Pathway
  54. Hepatoprotective Effect of Quercetin on Endoplasmic Reticulum Stress and Inflammation after Intense Exercise in Mice through Phosphoinositide 3-Kinase and Nuclear Factor-Kappa B
  55. Quercetin ameliorates peripheral nerve ischemia–reperfusion injury through the NF-kappa B pathway
  56. Induction of apoptosis and NF-$kappa$B by quercetin in growing murine L1210 lymphocytic leukaemic cells potentiated by TNF
  57. Quercetin Mitigates Inflammatory Responses Induced by Vascular Endothelial Growth Factor in Mouse Retinal Photoreceptor Cells through Suppression of Nuclear Factor Kappa B
  58. Quercetin and Vitamin C Mitigate Cobalt Chloride-Induced Hypertension through Reduction in Oxidative Stress and Nuclear Factor Kappa Beta (NF-Kb) Expression in Experimental Rat Model
  59. Impact of Quercetin, Diallyl Disulfide and Nimbolide on the Regulation of Nuclear Factor Kappa B Expression in Prostate and Breast Cancer Cell Lines
  60. Quercetin Ameliorates NO Production via Down-regulation of iNOS Expression, NFκB
    Activation and Oxidative Stress in LPS-Stimulated Macrophages
  61. EFFECT OF QUERCETIN AND GLIBENCLAMIDE COMBINATION ON CARDIAC MUSCLE NUCLEAR FACTOR KAPPA B (NF-KB) EXPRESSION IN TYPE 2 DIABETIC RATS
  62. Effects of Quercetin and Omega-3 Combination on Nuclear Factor Kappa B (NFκB) Expression Level in Pancreatic Tissue of Rats with Type-2 Diabetes Mellitus

  1. Data Analysis for Different Proportions in Clinic Application of Radix Angelicae sinensisand Radix Astragali
  2. An herbal decoction of Radix astragali and Radix angelicae sinensis promotes hematopoiesisand thrombopoiesis
  3. A Chinese Herbal Decoction, Danggui Buxue Tang, Prepared from Radix Astragali and Radix Angelicae Sinensis Stimulates the Immune Responses
  4. Hematopoietic effect of Radix angelicae sinensisin a hemodialysis patient
  5. Chemical and Biological Assessment of a Traditional Chinese Herbal Decoction Prepared from Radix Astragali and Radix Angelicae Sinensis: Orthogonal Array Design to Optimize the Extraction of Chemical Constituents
  6. Identification of Antioxidants in Essential Oilof Radix Angelicae Sinensis Using HPLC Coupled with DAD-MS and ABTS-Based Assay
  7. Protective effect of Danggui (Radix Angelicae Sinensis) on angiotensin II-induced apoptosis in H9c2 cardiomyoblast cells
  8. Differentiation of human adipose-derived stem cells into neuron-like cellsby Radix Angelicae Sinensis
  9. Radix Angelicae Sinensisand Radix Hedysari enhance radiosensitivity of 12C6+ radiation in human liver cancercells by modulating apoptosis protein
  10. Anti-inflammatoryeffectof radix Angelicae sinensis
  11. Z-ligustilide isolated from Radix Angelicae sinensis ameliorates the memory impairmentinduced by scopolamine in mice
  12. Two glutathione S‐transferase inhibitors from Radix Angelicae sinensis
  13. Anti-inflammatoryEffect of Radix Angelicae Sinensis
  14. Effect of Propranolol on Attenuation of Rat Hypoxic Pulmonary Hypertension due to Radix Angelicae Sinensis
  15. Component Analysis of SFE-CO_2 Extracts of Radix Angelicae sinensis,Rhizoma Chuanxiong and Their Drug Partnership by GC-MS
  16. Correlation between Antioxidant Activitiesand Phenolic Contents of Radix Angelicae Sinensis (Danggui)
  17. Chemical and Biological Assessment of a Chinese Herbal Decoction Containing Radix Astragali and Radix Angelicae Sinensis:  Determination of Drug Ratio in Having Optimized Properties
  18. Perimenopause Amelioration of a TCM Recipe Composed of Radix Astragali, Radix Angelicae Sinensis, and Folium Epimedii: An In Vivo Study on Natural Aging Rat Model
  19. Effects of radix Angelicae sinensison hemorrheology in patients with acute ischemic stroke.
  20. [Effects of Radix angelicae sinensison systemic and portal hemodynamics in cirrhotics with portal hypertension].
  21. [Effect of radix Angelicae sinensison serum gastrin levels in patients with cirrhosis].
  22. Effects of Radix Angelicae Sinensis, Radix Astragali and their compatiblities on Platelet aggregationand changes of cAMP and cGMP in platelet
  23. A Chinese Herbal Decoction, Dang Gui Bu Xue Tang, Prepared from Radix Astragali and Radix Angelicae sinensis,Ameliorates Insulin ResistanceInduced by A High-Fructose Diet in Rats
  24. A Chinese Herbal Decoction Prepared from Radix Astragali and Radix Angelicae Sinensis Induces the Expression of Erythropoietinin Cultured Hep3B Cells
  25. Effects of Radix Angelicae sinensisand shuanghuanglian on a rat model of chronic Pseudomonasaeruginosa pneumonia.
  26. Effects of Radix Angelicae Sinensisand Rhizoma Chuanxiong on Mouse Uterine Contractions in Vitro
  27. [Adjustment effect of Radix Astragalus and Radix Angelicae sinensison TNF-alpha and bFGF on renal injury induced by ischemia reperfusion in rabbit].
  28. Effect of Volatile Oil of Radix Angelicae Sinensison Percutaneous Absorption of Ferulic Acid
  29. [Study on the dynamic variations of Z-ligustilide and n-butylidenephthalide content in essential oil of radix angelicae sinensisfrom different growthperiod].
  30. Effect of Ultrasonic Extractionon Chemical Compositions in Fluid Extract of Radix Angelicae Sinensis
  31. Effects of Radix Angelicae Sinensis on changes of IL-6, TNF-? and bFGF in renal ischemia/reperfusion injury in rabbits

  1. Rehmannia glutinosa Activates Intracellular AntioxidantEnzyme Systems in Mouse Auditory Cells
  2. Protective effect of Rehmannia glutinosa on the cisplatin-induced damageof HEI-OC1 auditory cells through scavenging free radicals
  3. [Cloning and expression analysis of a tyrosine decarboxylase gene from Rehmannia glutinosa].
  4. Rehmannia glutinosa:Tissue Culture and Its Potential for Improvement
  5. Simultaneous Analysis of Bioactive Metabolites from Rehmannia glutinosaby HPLC-DAD-MS/MS
  6. QUALITY ASSURANCE OF CHINESEHERBAL DRUGS CONSIDERING ASEXAMPLE REHMANNIA GLUTINOSAAND STEPHANIA TETRANDRA
  7. Sorting and identification of Rehmannia glutinosagermplasm resources based on EST-SSR, scanning electron microscopy micromorphology, and quantitative taxonomy
  8. Rehmannia glutinosa exhibits anti‐aging effectthrough maintaining the quiescence and decreasing the senescence of hematopoietic stem cells
  9. Composition containing composite extract of rehmannia glutinosaand pueraria lobata for preventing or treating menopausal symptoms
  10. The enhanced immune responseof PCV-2 vaccine using Rehmannia glutinosapolysaccharide liposome as an adjuvant
  11. Rehmannia glutinosapolysaccharide promoted activation of human dendritic cells
  12. Rehmannia GlutinosaPharmacopuncture Solution Regulates Functional Activation, FcεRI Expression, and Signaling Events in Mast Cells
  13. Puffing of Rehmannia glutinosa enhances anti-oxidantcapacity and down-regulates IL-6production in RAW 264.7 cells
  14. Rehmannia glutinosapolysaccharide functions as a mucosal adjuvant to induce dendritic cell activationin mediastinal lymph node
  15. Anti-inflammatoryActivitiesof Ethylacetate Extract of Rehmannia glutinosain LPS-induced RAW 264.7 Cells
  16. Effect of Rehmannia glutinosaon immediate type allergic reaction
  17. Rehmannia glutinosa Suppresses Inflammatory ResponsesElicited by Advanced Glycation End Products
  18. Rehmannia glutinosa(Gaertn.) DC. polysaccharide ameliorates hyperglycemia, hyperlipemia and vascular inflammationin streptozotocin-induced diabetic mice
  19. Immunoenhancement effect of rehmannia glutinosapolysaccharide on lymphocyte proliferation and dendritic cell
  20. Hot Water Extracted Lycium Barbarum and Rehmannia Glutinosa Inhibit Liver Inflammationand Fibrosis in Rats
  21. Bioassay-guided isolation of anti-inflammatory components from the root of Rehmannia glutinosaand its underlying mechanism via inhibition of iNOS pathway
  22. Rehmannia glutinosaameliorates scopolamine-induced learning and memory impairment in rats.
  23. Topical application of Rehmannia glutinosa extract inhibits mite allergen-induced atopic dermatitisin NC/Nga mice
  24. Plasma Glucose Lowering Mechanisms of Catalpol, an Active Principle from Roots of Rehmannia glutinosa, in Streptozotocin-Induced Diabetic Rats
  25. Rehmannia glutinosa ameliorates the progressive renal failureinduced by 5/6 nephrectomy
  26. Characterization of the Anti-Diabetic and Antioxidant Effectsof Rehmannia Glutinosain Streptozotocin-Induced Diabetic Wistar Rats
  27. Antidiabetic and antioxidant effects of catalpol extracted from Rehmannia glutinosa (Di Huang) on rat diabetesinduced by streptozotocin and high-fat, high-sugar feed
  28. The Effects of Rehmannia glutinosaon the Protein Expression Related to the Angiogenesis, Cell Survival and Inflammation
  29. Treatment of Primary Chronic Glomerulonephritis with Rehmannia GlutinosaActeosides in Combination with the Angiotensin Receptor Blocker Irbesartan: A Randomized Controlled Trial
  30. Protective effect of Rehmannia glutinosaon the cisplatin-induced damage of HEI-OC1 auditory cells through scavenging free radicals

  1. Anti-inflammatoryEffect of Resveratroland Polydatin by In Vitro IL-17Modulation
  2. Decreased severity of experimental autoimmune encephalomyelitis during resveratroladministration is associated with increased IL-17+IL-10+ T cells, CD4− IFN-γ+ cells, and decreased macrophage IL-6expression
  3. Resveratrolinhibits high glucose-induced PI3K/Akt/ERK-dependent interleukin-17 expressionin primary mouse cardiac fibroblasts
  4. Resveratrolmodulates murine collagen-induced arthritis by inhibiting Th17 and B-cell function
  5. Anti-inflammatoryeffect of resveratrolin old mice liver
  6. Resveratrolameliorates diabetes-induced renal damage through regulating the expression of TGF-β1, collagen IV and Th17/Treg-related cytokinesin rats
  7. Anti-InflammatoryEffects of Resveratrol, Curcumin and Simvastatin in Acute Small Intestinal Inflammation
  8. Resveratrol-Mediated Gamma Interferon Reduction Prevents Airway Inflammationand Airway Hyperresponsiveness in Respiratory Syncytial Virus-Infected Immunocompromised Mice
  9. Effect of resveratrolon Treg/Th17 signalingand ulcerative colitis treatment in mice
  10. Regulatory role of resveratrolon Th17in autoimmune disease
  11. ResveratrolAmeliorates Imiquimod-Induced Psoriasis-Like Skin Inflammationin Mice
  12. Alteration of Hepatic Proinflammatory Cytokinesis Involved in the Resveratrol-Mediated Chemoprevention of Chemically-Induced Hepatocarcinogenesis
  13. Dietary supplementation of resveratrolattenuates chronic colonic inflammationin mice
  14. Resveratrolprotects diabetic kidney by attenuating hyperglycemia-mediated oxidative stressand renal inflammatory cytokinesvia Nrf2–Keap1 signaling
  15. Ameliorative potential of resveratrolon proinflammatory cytokines, hyperglycemia mediated oxidative stress, and pancreatic β‐cell dysfunction in streptozotocin‐nicotinamide‐induced diabetic rats
  16. Resveratrolretards progression of diabetic nephropathy through modulations of oxidative stress, proinflammatory cytokines, and AMP-activated protein kinase
  17. One-year supplementation with a grape extract containing resveratrolmodulates inflammatory-related microRNAs and cytokines expressionin peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease
  18. Inhibition of nitric oxide and inflammatory cytokinesin LPS-stimulated murine macrophages by resveratrol, a potent proteasome inhibitor
  19. Resveratrolattenuates hyperglycemia-mediated oxidative stress, proinflammatory cytokinesand protects hepatocytes ultrastructure in streptozotocin–nicotinamide-induced experimental diabetic rats
  20. Resveratrolincreases antioxidant defenses and decreases proinflammatory cytokinesin hippocampal astrocyte cultures from newborn, adult and aged Wistar rats
  21. ResveratrolAttenuates CoCl2-Induced Cochlear Hair Cell Damagethrough Upregulation of Sirtuin1 and NF-κB Deacetylation
  22. Inhibitory Effects of Resveratrolon Melanin Synthesis in Ultraviolet B-Induced Pigmentation in Guinea Pig Skin
  23. ResveratrolAmeliorates Dysregulation of Th1, Th2, Th17, and T Regulatory Cell-RelatedTranscription Factor Signaling in a BTBR T + tf/J Mouse Model of Autism
  24. Resveratrolprevents suppression of regulatory T-cell production, oxidative stress, and inflammationof mice prone or resistant to high-fat diet–induced obesity
  25. Anti-inflammatoryEffectsof Resveratroland Its Potential Use in Therapy of Immune-mediated Diseases
  26. Amelioration of oxidative stressby antioxidants and resveratrolin PC12 cells
  27. Resveratrolincreases vascular oxidative stressresistance
  28. Protective effect of resveratrolagainst oxidative stressin middle cerebral artery occlusion model of stroke in rats
  29. Resveratrolattenuates mitochondrial oxidative stressin coronary arterial endothelial cells
  30. Resveratrolinduces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stressin human lung epithelial cells
  31. Resveratrol suppresses IL-6-induced ICAM-1 gene expression in endothelial cells: Effects on the inhibition of STAT3 phosphorylation
  32. Resveratrol induces apoptosis, influences IL-6and exerts immunomodulatory effect on mouse lymphocytic leukemia both in vitro and in vivo
  33. Resveratrol Inhibits Respiratory Syncytial Virus-Induced IL-6Production, Decreases Viral Replication, and Downregulates TRIF Expression in Airway Epithelial Cells
  34. Resveratrol inhibits IL‐6‐induced ovarian cancer cell migration through epigenetic up‐regulation of autophagy
  35. Resveratrol, a sirtuin 1 activator, increases IL-6production by peripheral blood mononuclear cells of patients with knee osteoarthritis
  36. Resveratrol Inhibits IL-6-Induced Transcriptional Activity of AR and STAT3 in Human Prostate Cancer LNCaP-FGC Cells
  37. Trans-Resveratrol Attenuates High Fatty Acid-Induced P2X7 Receptor Expression and IL-6Release in PC12 Cells: Possible Role of P38 MAPK Pathway
  38. Resveratrol reduces IL-6and VEGF secretion from co-cultured A549 lung cancer cells and adipose-derived mesenchymal stem cells
  39. Inhibitory effects of resveratrol on MCP-1, IL-6, and IL-8 production in human coronary artery smooth muscle cells
  40. Resveratrol inhibits the IL-1β-induced expression of MMP-13 and IL-6in human articular chondrocytes via TLR4/MyD88-dependent and -independent signaling cascades
  41. Function of sustained released resveratrol on IL-1β-induced hBMSC MMP13 secretion inhibition and chondrogenic differentiation promotion
  42. Resveratrol inhibition of TNF-αand IL-1 for treatment of rheumatoid arthritis: from In-Silico to In-vitro elucidation
  43. Resveratrol Protects against Sepsis-Associated Encephalopathyand Inhibits the NLRP3/IL-1?Axis in Microglia
  44. RESVERATROL, THE ANTIOXIDANT OF RED WINE,PREVENTS IL-1 MEDIATED MITOCHONDRIALDYSFUNCTION AND ATP DEPLETION: ROLE OF PGE2AS A CAUSE OF CELLULAR ENERGY DEPLETION
  45. Effect of resveratrol on the expression of TNF-αand IL-1 in dorsal root ganglion neuron after auto-transplantation of nucleus pulposus in rat model
  46. PENGARUH RESVERATROL TERHADAP KADAR IL-5, EOSINOFIL DARAH, %VEP 1 DAN SKOR ACT PENDERITA ASMA
  47. Resveratrol inhibits nitric oxide and TNF-αproduction by lipopolysaccharide-activated microglia
  48. Resveratrol attenuates TNF-α-induced activation of coronary arterial endothelial cells: role of NF-κB inhibition
  49. Anti-inflammatory effect of resveratrol on TNF-α-induced MCP-1 expression in adipocytes
  50. Resveratrol inhibits TNF-α-induced changes of adipokines in 3T3-L1 adipocytes
  51. Resveratrol Inhibits TNF-α–Induced Proliferation and Matrix Metalloproteinase Expression in Human Vascular Smooth Muscle Cells
  52. Resveratrol prevents TNF-α-induced muscle atrophy via regulation of Akt/mTOR/FoxO1 signaling in C2C12 myotubes
  53. Resveratrol inhibits TNF-α-induced IL-1β, MMP-3 production in human rheumatoid arthritis fibroblast-like synoviocytes via modulation of PI3kinase/Akt pathway
  54. RV09, a novel resveratrol analogue, inhibits NO and TNF-αproduction by LPS-activated microglia
  55. Resveratrol is an effective inducer of CArG-driven TNF-αgene therapy
  56. Resveratrol enhances TNF-αproduction in human monocytes upon bacterial stimulation
  57. The anti-inflammatory activity of the polyphenol resveratrol may be partially related to inhibition of tumour necrosis factor-α (TNF-α) pre-mRNA splicing
  58. Inhibition of TNF‐α‐mediated endothelial cell–monocyte cell adhesion and adhesion molecules expression by the resveratrol derivative, trans‐3,5,4′‐trimethoxystilbene
  59. Resveratrol Protects against TNF-α-Induced Injury in Human Umbilical Endothelial Cells through Promoting Sirtuin-1-Induced Repression of NF-KB and p38 MAPK
  60. Resveratrol Reduces TNF-α-induced U373MG Human Glioma Cell Invasion through Regulating NF-κB Activation and uPA/uPAR Expression
  61. Effect of cis-resveratrol on genes involved in nuclear factor kappa B signaling
  62. Resveratrol inhibits VEGF expression of human hepatocellular carcinoma cells through a NF-kappa B-mediated mechanism.
  63. Effect of resveratrol on activation of nuclear factor kappa-B and inflammatory factors in rat model of acute pancreatitis
  64. Resveratrol Enhances Radiosensitivity of Human Non-Small Cell Lung Cancer NCI-H838 Cells Accompanied by Inhibition of Nuclear Factor-Kappa B Activation
  65. Resveratrol Inhibits Nitric Oxide-Induced Apoptosis via the NF-Kappa B Pathway in Rabbit Articular Chondrocytes
  66. Protective effects of chronic resveratrol treatment on vascular inflammatory injury in streptozotocin-induced type 2 diabetic rats: Role of NF-kappa B signaling
  67. Resveratrol Attenuates Oxidative Stress Induced by Balloon Injury in the Rat Carotid Artery Through Actions on the ERK1/2 and NF-Kappa B Pathway
  68. The effects of resveratrol on cyclooxygenase-1 and -2, nuclear factor kappa beta, matrix metalloproteinase-9, and sirtuin 1 mRNA expression in hearts of streptozotocin-induced diabetic rats
  69. Resveratrol mitigates hepatic injury in rats by regulating oxidative stress, nuclear factor-kappa B, and apoptosis
  70. Genetically Engineered Resveratrol-Enriched Rice Inhibits Neuroinflammation in Lipopolysaccharide-Activated BV2 Microglia Via Downregulating Mitogen-Activated Protein Kinase-Nuclear Factor Kappa B Signaling Pathway
  71. Effects of resveratrol on NF Kappa B modulation and squamous cell proliferation
  72. Abstract 1025: Resveratrol Attenuates Oxidative/Nitrative Stress in Diabetes Mellitus by inhibiting TNF alpha induced NF kappa B activation
  73. Inhibition of the Expression of Matrix Metalloproteinases in Articular Chondrocytes by Resveratrol through Affecting Nuclear Factor-Kappa B Signaling Pathway

  1. Sanguisorba Officinalis Root ExtractHas FGF-5 Inhibitory Activity and Reduces Hair Lossby Causing Prolongation of the Anagen Period
  2. Use of at least one extract of a rosacea of the genus Sanguisorba officinalisfor promoting pigmentation of the skin and/or the body hair and/or the cranial hair
  3. The Inhibitory Effect of an Extract of Sanguisorba officinalis L.on Ultraviolet B-Induced Pigmentationvia the Suppression of Endothelin-Converting Enzyme-1α
  4. Synergistic topical application of salt-processed Phellodendron amurense and Sanguisorba officinalis Linnealleviates atopic dermatitis symptoms by reducing levels of immunoglobulin E and pro-inflammatory cytokines in NC/Nga mice
  5. Burn wound healing potentialof a polysaccharide from Sanguisorba officinalis L.in mice
  6. Promotion of anagen, increased hair densityand reduction of hair fall in a clinical setting following identification of FGF5-inhibiting compoundsvia a novel 2-stage process
  7. Healing effect of Sanguisorba officinalis Lextract on second-degree burns in rats
  8. Sanguisorba officinalis extract, ziyuglycoside I, and II exhibit antiviral effectsagainst hepatitis B virus
  9. Inhibitory Effect of Sanguisorba officinalis Extracton Lipopolysaccharide-induced Pro-inflammatoryEvents in Macrophages
  10. In vivo antiviral activitiy of Sanguisorba officinalis rootsagainst viral hemorrhagic septicemia virus in olive flounder Paralichthys olivaceus
  11. Chemical constituents from Sanguisorba officinalis L. and their inhibitory effects on LPS-stimulated pro-inflammatory cytokine productionin bone marrow-derived dendritic cells
  12. ANTI-ALLERGIC EFFECTS OF SANGUISORBA OFFICINALISON ANIMAL MODELS OF ALLERGIC REACTIONS
  13. Anti-allergic inflammatorycomponents from Sanguisorba officinalis L
  14. Ethanol extracts of Sanguisorba officinalis L.suppress TNF-α/IFN-γ-induced pro-inflammatory chemokineproduction in HaCaT cells
  15. A hot‐water extract of Sanguisorba officinalis ameliorates endotoxin‐induced septic shockby inhibiting inflammasome activation
  16. Inhibitory effect of Sanguisorba officinalisethanol extract on NO and PGE2 production is mediated by suppressionof NF-κB and AP-1 activation signaling cascade
  17. Anti-asthmatic effect of Sanguisorba officinalis L.and potential role of heme oxygenase-1 in an ovalbumin-induced murine asthma model
  18. Anti-Wrinkle Activity of Ziyuglycoside I Isolated from a Sanguisorba officinalis Root Extractand Its Application as a Cosmeceutical Ingredient
  19. Methanol extract of Sanguisorba officinalis L.with cytotoxic activity against PC3 human prostate cancer cells
  20. The Inhibitory Effect of Triterpenoid GlycosidesOriginating from Sanguisorba officinalison Tissue Factor Activity and the Production of TNF-α
  21. Chemical Composition, Antioxidant and Antimicrobial Activitiesof Sanguisorba officinalis L. Extracts
  22. Triterpenoid saponins of Sanguisorba officinalisand their anti-inflammatoryactivity
  23. Sanguisorba officinalis L. ExtractsExert Antiobesity Effectsin 3T3-L1 Adipocytes and C57BL/6J Mice Fed High-Fat Diets
  24. Ethanol extract of Sanguisorba officinalis L. inhibits biofilm formationof methicillin-resistant Staphylococcus aureus in an ica-dependent manner
  25. Apoptotic effectof hot water extract of Sanguisorba officinalis L. in human oral cancer cells
  26. Determination of free and bounded phenolic acids in the rhizomes and herb of Sanguisorba officinalis L.
  27. Extracts of the medicinal herb Sanguisorba officinalisinhibit the entry of human immunodeficiency virus-1
  28. Saponins from Sanguisorba officinalis Improve Hematopoiesisby Promoting Survival through FAK and Erk1/2 Activation and Modulating Cytokine Production in Bone Marrow
  29. Sanguisorba officinalis Lsynergistically enhanced 5-fluorouracil cytotoxicity in colorectal cancer cells by promoting a reactive oxygen species-mediated, mitochondria-caspase-dependent apoptotic pathway
  30. Antioxidant Activity and Antimicrobial Effectfor Foodborne Pathogens from Extract and Fractions of Sanguisorba officinalis L.

  1. Silibinininhibits cytokine-inducedsignaling cascades and down-regulates inducible nitric oxide synthase in human lung carcinoma A549 cells
  2. GrowthInhibition and Regression of Lung Tumors by Silibinin: Modulation of Angiogenesis by Macrophage-Associated Cytokinesand Nuclear Factor-κB and Signal Transducers and Activators of Transcription 3
  3. Silibininmodulates the NF-κb pathway and pro-inflammatory cytokine productionby mononuclear cells from preeclamptic women
  4. Hesperidin and Silibinin Ameliorate Aluminum-Induced Neurotoxicity: Modulation of Antioxidants and InflammatoryCytokines Levelin Mice Hippocampus
  5. Silibinininhibits the production of pro-inflammatory cytokinesthrough inhibition of NF-κB signaling pathway in HMC-1 human mast cells
  6. Silibininattenuates oxidativemetabolism and cytokine production by monocytes from preeclamptic women
  7. Silibininattenuates allergic airway inflammationin mice
  8. Silibinin Inhibits Inflammatoryand Angiogenic Attributes in Photocarcinogenesis in SKH-1 Hairless Mice
  9. Silibinin alleviates inflammationand induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes and has a therapeutic effect on arthritis in rats
  10. Effects of Silibininon Hair FollicleStem CellsDifferentiation to Neural-like Cells
  11. Oxaliplatin-Induced Neuropathy: Oxidative Stressas Pathological Mechanism. Protective Effect of Silibinin
  12. Hydrogel containing silibinin-loaded pomegranate oil based nanocapsules exhibits anti-inflammatoryeffectson skin damage UVBradiation-induced in mice
  13. SilibininInhibits Tumor Promotional Triggers and Tumorigenesis Against Chemically Induced Two-Stage Skin Carcinogenesis in Swiss Albino Mice: Possible Role of Oxidative Stressand Inflammation
  14. Role of p53 in silibinin-mediated inhibition of ultraviolet B radiation-induced DNA damage, inflammationand skin carcinogenesis
  15. Neurotrophic Effects of Silibininon Differentiation of Hair FollicleStem Cellsto Neurons
  16. Neurotrophic Effects of Silibininon Differentiation of Hair FollicleStem Cellsto Neurons
  17. Flavonoid Silibinin Increases Hair-Inductive PropertyVia Akt and Wnt/β-Catenin Signaling Activation in 3-Dimensional-Spheroid Cultured Human Dermal Papilla Cells
  18. Silibinininhibits ultraviolet B radiation‐induced mast cells recruitment and bone morphogenetic protein 2 expression in the skin at early stagesin Ptch(+/−) mouse model of basal cell carcinoma
  19. Behavioral and neurochemical deficits in aging ratswith increased neonatal iron intake: silibinin’sneuroprotection by maintaining redox balance
  20. Silibininprevents amyloidbpeptide-inducedmemory impairment and oxidative stressin mice
  21. SilibininPrevents Autophagic Cell Death upon Oxidative Stressin Cortical Neurons and Cerebral Ischemia-Reperfusion Injury
  22. SilibininAttenuates Amyloid β25–35 Peptide-Induced Memory Impairments: Implication of Inducible Nitric-OxideSynthase and Tumor Necrosis Factor-α in Mice
  23. Silibinininhibits ultraviolet B radiation‐induced DNA‐damage and apoptosis by enhancing interleukin‐12 expression in JB6 cells and SKH‐1 hairless mouse skin
  24. Silibininstrongly inhibits the growthkinetics of colon cancer stem cell-enriched spheroids by modulating interleukin 4/6-mediatedsurvival signals
  25. Silymarininhibits UV radiation-induced immunosuppression through augmentation of interleukin-12 in mice
  26. Silibininameliorates arsenic induced nephrotoxicity by abrogation of oxidative stress, inflammationand apoptosis in rats
  27. SilibininAttenuates Sulfur Mustard Analog-Induced Skin Injury by Targeting Multiple Pathways Connecting Oxidative Stressand Inflammation
  28. Silibininpotentially attenuates arsenic-induced oxidative stressmediated cardiotoxicity and dyslipidemia in rats
  29. SilibininIs a Potent Sensitizer of UVA Radiation‐induced Oxidative Stressand Apoptosis in Human Keratinocyte HaCaT Cells
  30. Silibininameliorates oxidative stressinduced aberrant crypt foci and lipid peroxidation in 1, 2 dimethylhydrazine inducedrat colon cancer
  31. Silibinin Inhibits the Invasion of IL-6-Stimulated Colon Cancer Cells via Selective JNK/AP-1/MMP-2 Modulation in Vitro
  32. Chemopreventive Effects of Silibinin on Colitis-Associated Tumorigenesis by Inhibiting IL-6/STAT3 Signaling Pathway
  33. Silibinin protects OTA‐mediated TNF‐α release from perfused rat livers and isolated rat Kupffer cells
  34. Silibinin Suppresses TNF-α-Induced MMP-9 Expression in Gastric Cancer Cells through Inhibition of the MAPK Pathway
  35. Silibinin modulates TNF‐α and IFN‐γ mediated signaling to regulate COX2 and iNOS expression in tumorigenic mouse lung epithelial LM2 cells
  36. Apoptosis Induction by OTA and TNF-αin Cultured Primary Rat Hepatocytes and Prevention by Silibinin
  37. Silibinin down-regulates FAT10 and modulate TNF-α/IFN-γ-induced chromosomal instability and apoptosis sensitivity
  38. Silibinin Improves TNF-αand M30 Expression and Histological Parameters in Rat Kidneys After Hepatic Ischemia/Reperfusion
  39. Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis
  40. Downregulation of nuclear factor-kappa B (NF-κB) pathway by silibinin in human monocytes challenged with Paracoccidioides brasiliensis
  41. Silibinin inhibits invasive properties of human glioblastoma U87MG cells through suppression of cathepsin B and nuclear factor kappa B-mediated induction of matrix metalloproteinase 9
  42. Silibinin Induces Apoptosis and Inhibits Proliferation of Estrogen Receptor (ER)-Negative Breast Carcinoma Cells through Suppression of Nuclear Factor Kappa B Activation

  1. The hair growthpromoting effectof Sophora flavescensextract and its molecular regulation
  2. Rhizobial Diversity and Nodulation Characteristics of the Extremely Promiscuous Legume Sophora flavescens
  3. Improvement of androgenetic alopeciawith topical Sophora flavescens Aiton extract,and identification of the two active compounds in the extract that stimulate proliferation of human hair keratinocytes
  4. Studies on the effect of Sophora flavescens extracton the hair growthstimulationand acne inhibition
  5. Ultrasound-assisted extraction of oxymatrine from Sophora flavescens
  6. Study on the Induction and Culture Condition of Hairy Roots of Sophora flavescensAit
  7. Effect of Sophora flavescensalkaloid on aerobic vaginitis in gel form for local treatment
  8. A New Lavandulylated Flavonoid from Sophora flavescensRoots
  9. Induction of Hairy Rootsand Determination of Oxymatrine in Sophora flavescens Ait.
  10. Preventive and Therapeutic Effectsof Traditional Medicines on Diabetic Complications: Sophora flavescens,Pueraria lobata, Coptis chinensis, Cirsium maackii, and Artemisia capillaries
  11. Anti-inflammatoryActivityof Trifolirhizin isolated from Methanol Extractof Sophora Flavescens Ait(the Sophorae Radix) in Experimental Animals
  12. Prenylated Flavonoids from the Roots of Sophora flavescens Promote Vascular Relaxationvia Endothelium-Dependent Mechansims
  13. Sophora flavescens Seedas a promising high potential by-product: Phytochemical characterization and bioactivity evaluation
  14. Sophoraflavanone G from Sophora flavescensinduces apoptosis in triple-negative breast cancer cells
  15. Efficiency of Sophora flavescens-Fructus Ligustri Lucidi Drug Pairs in the Treatment of Liver Fibrosis Based on the Response Surface Method
  16. Anti-inflammatoryand anti-arthritic activityof total flavonoids of the roots of Sophora flavescens
  17. Anti-Inflammatoryand Antiproliferative Activitiesof Trifolirhizin, a Flavonoid from Sophora flavescens Roots
  18. Attenuation of ERK/RSK2-Driven NFκB Gene Expression and Cancer Cell Proliferationby Kurarinone, a Lavandulyl Flavanone Isolated from Sophora flavescens Ait. Roots
  19. Sophora flavescens Aitoninhibits the production of pro-inflammatory cytokines through inhibition of the NF κB/IκB signal pathway in human mast cell line (HMC-1)
  20. Anti-inflammatoryeffect of sophoraflavanoneG isolated from Sophora flavescens in lipopolysaccharide-stimulated mouse macrophages
  21. Anti-inflammatoryand Anti-oxidant Effects of Sophora flavescens Root Extractionin Lipopolysaccharide-activated Raw 264.7 Cells.
  22. Hepatoprotective and inhibiting HBV effectsof polysaccharides from roots of Sophora flavescens
  23. In vivo and in vitro anti-inflammatoryeffects of Sophora flavescens residues
  24. Simultaneous quantification of multiple alkaloids in Sophora FlavescensAit and human urine by HPLC
  25. The Effect of Allergic Inflamation by Sophora FlavescensAiton Extract Ion Through Inhibition of the NFκB, JNK and p38 Pathway
  26. Sophora flavescens protects against mycobacterialTrehalose Dimycolate-induced lung granuloma by inhibiting inflammationand infiltration of macrophages
  27. Antibacterial and Anti-inflammatoryActivityof Traditional Chinese Herb Pairs, Angelica sinensis and Sophora flavescens
  28. Anti-inflammatoryeffectsof fermented and non-fermented Sophora flavescens: a comparative study
  29. Effect of Sophora flavescensAiton extract on degranulation of mast cells and contact dermatitis induced by dinitrofluorobenzene in mice
  30. Anti‐Inflammatoryand PPAR Transactivational Properties of Flavonoids from the Roots of Sophora flavescens
  31. The Effect of Allergic Inflamation by Sophora Flavescens Aiton Extract Ion Through Inhibition of the NFκB
    , JNK and p38 Pathway
  32. Sophora Flavescens Suppresses Degranulation and Pro-inflammatory Cytokines Production through the Inhibition of NF-κB
    (p65) Activation in the RBL-2H3 cells


Reduction in human hair graying by sterubin, an active flavonoid of Eriodictyon angustifolium
Hair pigmentation could be improved by altering melanocyte number and gene activity. Cytokines such as Kitl and Endothelins are known to promote the proliferation of melanocytes and upregulate their pigmentation genes.  Recently, the WNT/β catenin produced by the follicular keratinocytes was found to function as an attractant of follicular melanocytes and activate microphthalmia-associated transcription factor (MITF), the master regulator of pigmentation genes of melanocytes.  Based on these notions, many synthetic or natural compounds, including plant extracts, that can upregulate pigmentation genes have been screened.  Depletion of follicular MSCs causes persistent loss of functional melanocytes from the hair matrix leading to graying, with no recovery expected. Gray hair-containing follicles that are depleted of MSCs increase along with the cumulative progression of the hair cycle with age.
Loss of proliferative ability of follicular keratinocytes, rather than MSCs, has also been reported in radiation-induced hair graying suggesting the involvement of keratinocytes in hair graying and their potential as a practical target for its prevention. Thus, owing to the complexity of the mechanisms underlying hair graying, a combination of in vitro and in vivoevaluation methods is necessary for screening effective molecules for the prevention and reduction of hair graying.

Sterubin is an active anti-inflammatory component of Yerba Santa (Eriodictyon angustifolium) Yerba Santa is a plant that grows on the west coast of North America and has been used for several years as a traditional medicine by the indigenous population. To investigate its ability to stimulate melanogenesis, we treated the human melanoma cell line HMVII with 5–10 μM of synthetic sterubin. The sterubin-treated cells showed 1.47- to 1.65-fold concentration-dependent increase (**p < 0.01) in melanin content after 7 days of exposure (Fig. 1A). Immunohistochemistry revealed nuclear translocation of β-catenin, which is indicative of WNT signaling activation, and nearly 1.4-fold increase in nuclear MITF expression (**p < 0.01) and 4.6-fold increase in cytoplasmic TYR expression (***p < 0.001) were observed in the treated cells (Fig. 1B-E).

In vitro effects of sterubin in the prevention of hair graying. (A) Melanin content of the HMVII melanoma cell line increased in a concentration-dependent manner following sterubin treatment. (B, C, D, E) Nuclear translocation of β-catenin and increased intensity of nuclear MITF and TYR staining after exposure to sterubin revealed by the immunocytochemistry. (F) NHEKs pretreated with the sterubin were exposed to 20 Gy X-ray and cell viability was determined. (G and H) γH2AX foci was measured in X-ray exposed NHEKs pretreated with sterubin.

Age-associated hair graying and radiation-induced hair graying have been suggested to share common cellular mechanisms [

Next, using the 2′,7′-dichlorofluorescein diacetate (DCF-DA) assay, we investigated whether sterubin could scavenge radiation-induced intracellular ROS. After exposure to 20 Gy of X-ray, increased fluorescence intensity of DCF was observed in NHEKs (DMSO-treated cells in Fig. 2A). As shown in Fig. 2A and B, 100 μM of synthetic sterubin significantly suppressed the radiation-induced generation of ROS from 33.4 to nearly the level observed in non-irradiated control cells (Sterubin + 20 Gy: 13.7, ***p < 0.001). ROS attack mitochondrial DNA and membrane proteins, thereby impairing mitochondrial function. Mito-tracker staining revealed that 100 μM of synthetic sterubin treatment for 1 h before irradiation significantly prevented severe deformation of the mitochondrial mass of NHEKs (DMSO + 20 Gy: 46.3, Sterubin + 20 Gy : 71.8, **p < 0.01) (Fig. 2C, D). These data suggest that sterubin contains active components that could effectively prevent hair graying by protecting follicular keratinocytes from age- and radiation-induced damage.

  1. Hair growth-promoting activity of hot water extract of Thuja orientalis
  2. Free radical scavenging and antielastase activities of flavonoids from the fruits of Thuja orientalis
  3. Isoquercitrin is the most effective antioxidant in the plant Thuja orientalis and able to counteract oxidative-induced damage to a transformed cell line (RGC-5 cells)
  4. Chemical Composition and Fungitoxic Activity of Essential Oil of Thuja orientalis L. Grown in the North-Western Himalaya
  5. Biosorption of Reactive Blue 49 dye under batch and continuous mode using a mixed biosorbent of macro-fungus Agaricus bisporus and Thuja orientalis cones
  6. Biflavonyl pigments from [the foliage of] Thuja orientalis
  7. Molluscicidal activity of Saraca asoca and Thuja orientalis against the fresh water snail Lymnaea acuminata
  8. Inhibitory effect of Thuja orientalis on TNF‐α‐induced vascular inflammation
  9. The mating system in natural populations of Thujaorientalis
  10. Protective effects of standardized Thuja orientalis leaves against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells
  11. GC analysis of essential oils in the rumen fluid after incubation of Thuja orientalis twigs in the Rusitec system
  12. A new labdane diterpenoid with anti-inflammatory activity from Thuja orientalis
  13. Antiviral Activity of the Plant Extracts from Thuja orientalis, Asterspathulifolius, and Pinus thunbergii Against Influenza Virus A/PR/8/34
  14. Response of vegetative growth and chemical constituents of Thuja orientalis L. plant to foliar application of different amino acids at Nubaria.
  15. Improved biosorption potential of Thuja orientalis cone powder for the biosorptive removal of Basic Blue 9
  16. Effects of Flooding of Soll on Growth, Stem Anatomy, and Ethylene Production of Thuja Orientalis Seedlings·
  17. Antibacterial, antioxidant andphytochemical investigation of Thuja orientalisleaves
  18. Anti-allergic effect of lambertianic acid from Thuja orientalis in mouse bone marrow-derived mast cells
  19. Larvicidal Activity of Chamaecyparis obtusa and Thuja orientalis Leaf Oils against Two Mosquito Species
  20. Flavonoids from the leaves of Thuja orientalis inhibit the aldose reductase and the formation of advanced glycation endproducts
  21. ANTIOXIDANT POTENTIAL OF VARIOUS EXTRACTS OF STEM OF THUJA ORIENTALIS: IN VITRO STUDY
  22. Three New Diterpenoids from the Leaves of Thuja orientalis
  23. ANTIMICROBIAL ACTIVITY OF THE ESSENTIAL OIL OF THUJA ORIENTALIS L
  24. Methylene chloride fraction of the leaves of Thuja orientalis inhibits in vitro inflammatory biomarkers by blocking NF-κB and p38 MAPK signaling and protects mice from lethal endotoxemia
  25. Efficiency of Thuja orientalis and Artimisia campestris extracts to control of Potato leaf roll virus (PLRV) in potato plants.
  26. Effect of the Semen Extract of Thuja orientalis on Inflammatory Responses in Transient Focal Cerebral Ischemia Rat Model and LPS-Stimulated BV-2 Microglia
  27. Batch and Dynamic Flow Biosorption Potential of Agaricus bisporus/Thuja orientalis Biomass Mixture for Decolorization of RR45 Dye
  28. Histopathology of Thuja orientalis and Juniperus horizontalis plumosa Infected with Meloidogyne incognita
  29. Chemical composition of Thuja orientalis L. essential oils and study of their allelopathic potential on germination and seedling growth of weeds
  30. Thuja orientalis reduces airway inflammation in ovalbumin-induced allergic asthma
  31. Inhibitory activity of Thuja orientalis on TNF-α-induced vascular cell adhesion in HUVECs

  1. Celastrolinhibits pro-inflammatory cytokinesecretion in Crohn’s disease biopsies
  2. Celastrolinhibits production of nitric oxide and proinflammatory cytokinesthrough MAPK signal transduction and NF-κB in LPS-stimulated BV-2 microglial cells
  3. CELASTROL, A POTENT ANTIOXIDANT AND ANTI-INFLAMMATORYDRUG, AS A POSSIBLE TREATMENT FOR ALZHEIMER’S DISEASE
  4. Celastrolameliorates murine colitis via modulating oxidative stress, inflammatorycytokinesand intestinal homeostasis
  5. Celastrolameliorates cytokine toxicity and pro-inflammatory immuneresponses by suppressing NF-κB activation in RINm5F beta cells
  6. Suppression ofinflammatoryresponses by celastrol, a quinone methide triterpenoid isolated from Celastrus regelii
  7. Modulation ofinflammatorysignaling and cytokinerelease from microglia by celastrol incorporated into dendrimer nanocarriers
  8. Celastrolsuppresses allergen-induced airway inflammationin a mouse allergic asthma model
  9. Celastrus-derived CelastrolSuppresses Autoimmune Arthritis by Modulating Antigen-induced Cellular and Humoral Effector Responses
  10. Suppression of autoimmune arthritis by Celastrus-derived Celastrolthrough modulation of pro-inflammatory chemokines
  11. Modulatory effect of celastrolon Th1/Th2 cytokinesprofile, TLR2 and CD3+ T-lymphocyte expression in a relapsing–remitting model of multiple sclerosis in rats
  12. CelastrolAttenuates Hypertension-Induced Inflammationand Oxidative Stressin Vascular Smooth Muscle Cells via Induction of Heme Oxygenase-1
  13. Celastrolnanomicelles attenuate cytokine secretionin macrophages and inhibit macrophage-induced corneal neovascularization in rats
  14. CelastrolAlleviates Airway Hyperresponsiveness and Inhibits Th17 Responsesin Obese Asthmatic Mice
  15. Control of autoimmune inflammationby celastrol, a natural triterpenoid
  16. Celastrol mediates Th17 and Treg cellgeneration via metabolic signaling
  17. Celastrolalleviates arthritis by modulating the inflammatoryactivitiesof neutrophils
  18. CelastrolLimits Autoimmune Arthritis by Reducing Th17 and Promoting Treg Cellsin Inflamed Joints
  19. CelastrolAlleviates Airway Hyperresponsiveness by Downregulating Th17in Obese Asthmatic Mice
  20. Celastrolattenuates oxidative stressin the skeletal muscle of diabetic rats by regulating the AMPK-PGC1α-SIRT3 signaling pathway
  21. Celastrol reduces IL-1β inducedmatrix catabolism, oxidative stressand inflammationin human nucleus pulposus cells and attenuates rat intervertebral disc degeneration in vivo
  22. CelastrolBlocks Interleukin-6 GeneExpression via Downregulation of NF-κB in Prostate Carcinoma Cells
  23. Celastrolinhibits interleukin-17A-stimulatedrheumatoid fibroblast-like synoviocyte migration and invasion through suppression of NF-κB-mediated matrix metalloproteinase-9 expression
  24. Therapeutic potential of interleukin-17 in inflammationand autoimmune diseases
  25. Celastrolameliorates experimental colitis in IL-10 deficientmice via the up-regulation of autophagy
  26. Celastrol inhibits IL-1β-induced inflammationin orbital fibroblasts through the suppression of NF-κB activity
  27. Celastroltreatment protects against acute ischemic stroke-induced brain injury by promoting an IL-33/ST2 axis-mediatedmicroglia/macrophage M2 polarization
  28. CelastrolPrevents Atherosclerosis via Inhibiting LOX-1 and Oxidative Stress
  29. Celastrolprotects mouse retinas from bright light-induced degeneration through inhibition of oxidative stressand inflammation
  30. Celastrolattenuates mitochondrial dysfunction and inflammationin palmitate-mediated insulin resistance in C3A hepatocytes
  31. Clinical evaluation of tripterygium wilfordii polyglycosidium combined with methotrexate in treating rheumatoid arthritis and its effect on TNF-αand IL-6.
  32. Inhibition of IL-1 release from human monocytes and suppression of streptococcal cell wall and adjuvant-induced arthritis in rats by an extract of Tripterygium wilfordii Hook
  33. Inhibitory effects of monomer T4 from Tripterygium wilfordii hook on cultured mesangial cells proliferation and IL-1 production
  34. Effects of Tripterygium wilfordii on the Production and Activities of IL－ 1 and IL－ 2 in vitro
  35. Effect of Tripterygium Wilfordii Hook f. on the Serum IL-6and TNF Levels in Patients with Chronic Nephritis
  36. The effects of cyclosporin A(CyA) and Tripterygium wilfordii on the expressions of IL 6 and IL 8 mRNA of human peripheral blood mononuclear cells(PBMCs) induced by recombinant human IL 1α(rhIL 1α)
  37. Effect of Tripterygium wilfordii combined with methotrexate on short-term effect of rheumatoid arthritis and the levels of IL-6, IL-10 and TNF- in peripheral blood
  38. EFFECTS OF CELASTROL ON IL-1 AND lL-2 PRODUCTION
  39. Celastrol Inhibits Lung Infiltration in Differential Syndrome Animal Models by Reducing TNF-αand ICAM-1 Levels while Preserving Differentiation in ATRA-Induced Acute Promyelocytic Leukemia Cells
  40. The effect of Celastrol on the expressions of RANKL,OPG,IL-6,TNF-αand IL-8 in human rheumatoid synoviocyte MH7A
  41. The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma
  42. NF-Kappa B Modulation Is Involved in Celastrol Induced Human Multiple Myeloma Cell Apoptosis
  43. Celastrol Inhibits Lipopolysaccharide-Induced Angiogenesis by Suppressing TLR4-Triggered Nuclear Factor-Kappa B Activation
  44. Synergism between NF-kappa B inhibitor, celastrol, and XIAP inhibitor, embelin, in an acute myeloid leukemia cell line, HL-60

    1. TriptolideInhibits the Differentiation of Th17 cellsand Suppresses Collagen‐induced Arthritis
    2. Th17/Treg imbalancein triptolide-induced liver injury
    3. [Triptolide inhibites Th17 cell differentiationvia regulating cyclooxygenase-2/ prostaglandin E2 axis in synovial fibroblasts from rheumatoid arthritis].
    4. Triptolideameliorates IL-10-deficientmice colitis by mechanisms involving suppression of IL-6/STAT3 signaling pathway and down-regulation of IL-17
    5. Quercetin protects mouse liver against triptolide-induced hepatic injury by restoring Th17/Treg balancethrough Tim-3 and TLR4-MyD88-NF-κB pathway
    6. Interleukin-17 mediatestriptolide-induced liver injury in mice
    7. Triptolideprotects mice from ischemia/reperfusion injury by inhibition of IL-17production
    8. Triptolideameliorates ileocolonic anastomosis inflammationin IL-10 deficientmice by mechanism involving suppression of miR-155/SHIP-1 signaling pathway
    9. Epigallocatechin-3-gallate Prevents Triptolide-Induced Hepatic Injury by Restoring the Th17/Treg Balance in Mice
    10. [Modulatory effect of triptolideon differentiation of human Th17 cells].
    11. Triptolideattenuates idiopathic pneumonia syndrome in a mouse bone marrow transplantation model by down-regulation of IL-17
    12. Triptolidesuppresses proinflammatory cytokine-inducedmatrix metalloproteinase and aggrecanase-1 gene expression in chondrocytes
    13. TriptolideInhibits Proliferation and Migration of Colon Cancer Cells by Inhibition of Cell Cycle Regulators and Cytokine Receptors
    14. TriptolideAttenuates Endotoxin- and Staphylococcal Exotoxin-Induced T-Cell Proliferation and Production of Cytokines and Chemokines
    15. Inhibition by Triptolideof Chemokine, Proinflammatory Cytokine, and Adhesion Molecule Expression Induced by Lipopolysaccharide in Corneal Fibroblasts
    16. Triptolideattenuates oxidative stress, NF-κB activation and multiple cytokine gene expressionin murine peritoneal macrophage
    17. Inhibitory Effect of Triptolideon Chemokine Expression Induced by Proinflammatory Cytokinesin Human Corneal Fibroblasts
    18. Triptolide induces anti-inflammatorycellular responses
    19. Triptolide,A Novel Immunosuppressive and Anti-InflammatoryAgent Purified from a Chinese Herb Tripterygium Wilfordii Hook F
    20. Preparation and anti-inflammatoryactivityof triptolideethosomes in an erythema model
    21. Therapeutic effects of triptolidevia the inhibition of IL-1β expressionin a mouse model of ulcerative colitis
    22. Acute and subacute toxicity studies on triptolideand triptolide-loadedpolymeric micellesfollowing intravenous administration in rodents
    23. Interleukin 6 inhibitionby triptolideprevents inflammationin a mouse model of ulcerative colitis
    24. Immunosuppressant PG490 (Triptolide)Inhibits T-cell Interleukin-2 Expressionat the Level of Purine-box/Nuclear Factor of Activated T-cells and NF-κB Transcriptional Activation
    25. Triptolidesuppresses T-lymphocyte proliferation by inhibiting interleukin-2 receptorexpression, but spares interleukin-2 productionand mRNA expression
    26. The suppressive effect of triptolideon chronic colitis and TNF-α/TNFR2 signal pathway in interleukin-10deficient mice
    27. Inhibitory effect of triptolideon interleukin-18and its receptor in rheumatoid arthritis synovial fibroblasts
    28. Therapeutic effects of triptolide on interleukin-10 gene-deficient mice with colitis
    29. Triptolidesuppresses interleukin-1β-inducedhuman β-defensin-2 mRNA expression through inhibition of transcriptional activation of NF-κB in A549 cells
    30. Interleukin-6-independent expressionof glucocorticoid receptor is upregulated by triptolidein multiple myeloma
    31. Triptolide inhibits TNF-α, IL-1β and NO production in primary microglial cultures
    32. Triptolide inhibits amyloid-β1-42-induced TNF-αand IL-1β production in cultured rat microglia
    33. Triptolide inhibits COX-2 expression by regulating mRNA stability in TNF-α-treated A549 cells
  1. Effect of triptolide on secretion of inflammatory cellular factors TNF-αand IL-8 in peritoneal macrophages of mice activated by lipopolysaccharide
  2. Relationship between single nucleotide polymorphism in TNF-αgene promoter region and inibitory effects of triptolide on TNF-αproduction in peripheral blood mononuclear cells of healthy humans
  3. Triptolide inhibits the function of TNF‑α in osteoblast differentiation by inhibiting the NF‑κB signaling pathway
  4. The Studies on Triptolide and TNF-αRegulating the Expression of Notch1 in Raji Cells


Mandatory FDA Disclaimer:

As with any supplement, consult your medical practitioner prior to using this product if you are pregnant, may become pregnant, breastfeeding, taking medication, other dietary supplements or have a medical condition.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.  *Daily Value has not been established.

27 reviews for SUPER TONIC HAIR

  1. Shelly –

    Wow! I am truly amazed at how quickly my scalp stopped itching only a few days of using this product! Gavin and his crew are stellar in what they do, I am a lifetime customer. This new Super HairTonic will not leave you disappointed! Once again, Interstellar crushed it!!!! Thank you for always providing quality top notch products!

  2. Chad –

    I ordered Super tonic hair as soon as it became available. First off, the taste when mixed into coffee makes the coffee taste better. This product is one you will look forward to buying again and again. After using for a week not only did my energy levels increase, but also my hair seems to be shiny, thicker and generally easier to work with. I wish that I had this product a year ago. Would’ve saved me a lot of money buying other hair products that didn’t work well. What an extraordinary product! Thank you Interstellar!! For the quality products and customer service!!!!

  3. Rich Ryan –

    I’ve always had thin hair and after about age 40 I started getting more and more hair in my combs and brushes. I wasn’t going bald, but my hair was breaking very easily. Haircuts became optional as my hair would only grow to shoulder length before breaking off. My hair and beard felt brittle and dry, and the skin underneath my beard dried out and itched constantly unless treated with something. Also most of my beard is grey now. I can see SuperHair slowly improving all these things. There’s less hair in my comb, my hair and beard feels softer and less brittle, and my scalp and facial skin under the beard feels healthier and itches considerably less. The grey hasn’t reversed yet, but I’ve only been on the blend for a couple weeks. I’ll post an update in a year or so when the blend has had a chance to work. Once again, an incredible product from Interstellar Blends!

  4. Tanya –

    I’ve been waiting a little to post a review on this product as I try to provide as much honest and authentic detail as possible. I have never been that girl with amazing hair. I’m not saying it’s bad but it’s fine and lacks volume. Combine that with thyroid issues and it had been dry and broken in the past. I’ve been on this blend about a month and this past week I’ve started to have great hair days. (Previously I may have had one great hair day per year! My hair is fuller, has more volume and shine. I’m totally sold on this blend. This one does take a little time I think – so give it an honest go

  5. Soma Felfoldi –

    First of all, I would just like to say that Im extremely grateful to Gavin! I have been in this health field for almost half a decade and tried numerous supplements on the market but I barely got any reaction to them sadly. I already started experimenting with the dry fast thank to this site and since my Peel, Super hair and pine pollen arrived the whole dry fasting became just so easy that I feel like I never want to go back to eating. And its only 9-10 days that I have been using them! What will happen after spending some months on the protocol? Holy Moly Im excited!! After I take the blends my brain just clears out, and I am able to use the brain just like when I was in my high school years- sharp, quick math calculations, more talkative and more convincing which is very important at my work! Since mentally Im working better it seems I can do much better at my hobby which is DIY little works for homes and carpentering. I totally believe that hands skills are coordinated by the brain and my improved performance is thanks to the mental clarity.

    The main reason why I got into the blends and protocol is that I have hair and skin issues since the age of 17. Now Im 27 and I dont want to shout too early but the nasty dermatitis seems to fade away finally from my face. I cant pinpoint exactly which herb does help with that but I dont even have to. I trust Gavin and the combo blends are created to work synergestically so they cannot not work! I always knew fruits and fruits skins are healthy but were never able to eat enough of them due to getting bloating. Now finally I can take the active substance from the fruits without getting bloated and this removed a huge mental burden from me that I finally get my anti oxidants. Since stressing used to increase my dermatitis and I havent had a flare up since the last 10 days!

    I still have way to go on this health journey as my body temperature is lower than it should be and Im very interested in the Thermo blend and 1-2 others suggested by some members of the dry fasting group. I know my protocol is not complete yet but if its working already this well, I cant wait what will happen once I could get my hands on some more blends! Gavin, thank you for setting up such a supportive community which gives people hope and finally something which is rarely achieved: success and results!

  6. Paula DeNote Zering –

    I am a hairstylist. I have my own salon and have been doing hair for over 25 years. My hair is semi fine, breaks easy and of course I want it longer. I have been on the blends for other reason as well. I take several but added Super Tonic Hair for the sole purpose of it not falling out when I lose weight. Today my daughter was applying my color and asked me what was going on with the front of my hair. It is usually all white. I told her I was taking the blends and it’s supposed to help with grey. She laughed and said I now have dark hairs growing where there was all white a few months ago. She couldn’t believe it. Neither could I. While this is great for some, we need to keep this on the down low! Lol! I make my living on coloring white hair back. Just kidding. This stuff is amazing!

  7. Amelia Jara –

    I strongly believe that God is uncovering things like Interstellar blends to prepare our minds for the tough time we are facing. People are full of anxiety and fear that release toxins in the brain and damage it and consequently not able to think straight and make right choices. I have been practicing fasting for many years for the positive effect it does to my mind, and for weight lost . However, it was very hard to do and the pounds I lost would come back right after I resume my eating.. I started using interstellar blend in July 2019 and it’s been one of the most amazing thing I have done in my life. They are autophagy activating herbs. Auto means self and phagy means eating. Those herbs activate a system in the body that takes broken proteins ,cells that are weak and bacteria’s that are creating problems and metabolize them and feeds the body with them.. Even though you are not eating, your body is feeding you breakfast , lunch and dinner with the raw material it contains . I love all the blends but the ones that I am the most excited about are Autophagy, Super Hair, pine pollen and Niagara. Autophagy suppresses my hunger like crazy for the same reason I just stated. My body is feeding me. Isn’t that awesome. I am always calm and my stress level is very low .. Niagara’s is awesome. My libido was very low because of problems with my hormones. The first week after I started using Niagara , my intimacy with my husband increased tremendously ,sex libido and stamina increased and painful sex disappeared. Super hair combined with pine pollen are amazing. I have very dry and curly hair that never grow. Now my hair is growing and is more manageable . I also see some black hair coming out of my white hair. When I first called Gavin, he immediately sent me some samples of Thermo, nebula,trinity, peel, spice , Seven Sages ,Shilajit and matcha green tea. The first week using them revolutionized my entire body and soul. I was losing so much weight that my husband started to complain. I moved from size medium to small and extra small. My pants size are from youth 3 to 5 and that’s because I eat a lot when I eat because my husband doesn’t like it when I am too skinny. Almost a month after I started using the herbs I went to a resort at the beach eating 3 huge meals a day and snacking and drinking in between meals for 10 days and when I came back to my normal fasting routine with the blends , the first week my body looked like if I didn’t go on vacation. I am always with a strong sense of hope and good expectations for the future. I don’t get tired or sick. Praise God! I added ACB and Luteolin. My mind is so sharp that I can dream for a better future with the expectancy of living a long and happy life. Every week I either do 88/8 or 66/6 which means don’t eat food for 88 hours and just take the blends every 4 hours , then feed for 8 hours. Then the other 2 days I do intermitting fasting. This is life saving for me. I lose a lot of weight , my mind is sharp at work and I don’t have to go to the stress of preparing food to take to work. Now I am not worried
    about gaining weight. My body only craves for healthy food and I am never tempted to eat the unhealthy food. My body is free from pain and inflammation and I am always looking forward to fast with the interstellar blends because of the sense of strength and encouragement I experience during the fast. I feel the presence of God in a strong way and I feel that I am stronger than the problems I face. I am always waiting for the next day with joy and positive expectations . Your body is your best friend that will be with you for the rest of your life and it is the vehicle that takes you to the places that bring you satisfaction and fulfillment in life. Therefore give it the best. Give it Intersteller blends. Your body will thank you and rejoice with you.

  8. Rochelle Vitler –

    I started using Auto, Thermo, Trinity, Super Hair and Pine Pollen approximately six weeks ago to support my overall health, mood and weight loss journey whilst undertaking a combination of 48-72 hour dry and water fasts.

    I had already been fasting for approximately two months at this point but almost straightaway after introducing the blends the fasting became a breeze. I have the energy and inclination to exercise every day; I enjoy a big meal every two to three days and the desire to eat outside of these times is simply not there.

    I have played around with the timing and combination of blends that works best for me and now believe I’ve got it just right. The best way to describe my mental state at the moment is “joyful”. I honestly feel happy, hopeful and uplifted, regardless of what stressors may be present in my life, and definitely attribute this to the blends.

    Added bonus: I have new hair growth all around my hairline. I feel my hair overall is thicker and in much better condition but the hairline is particularly noticeable.

    I can’t wait to try the next batch of blends I have ordered and will gradually add others. These blends really have made a big difference to my life and after seeing the benefits I wouldn’t want to be without them.

  9. Claudia Gonzalez –

    I purchased Superhair Tonic back in December. I had been water fasting (without blends) since August and managed to lose 30 lbs. However, by December I noticed I had started to shed tons of hair. Taking a shower caused severe anxiety since its when I saw the most hair fall out. Hand fulls of my long 30 inch hair were falling out. I had just come across the Facebook group and saw this blend. I ordered immediately. I took this combined with the Pine Pollen and within two weeks all hair loss had stopped. I was so amazed and thrilled.

    I think the water fasting has also stunned my hair growth. I hadn’t seen much growth in the last couple of months. After a couple of weeks on the Superhair Tonic and Pine Pollen I noticed that my hair was growing again. I documented the growth and from the end of December to February my hair grew 3 inches! Not only that but I have tons of baby hair already growing in replacing all the hair I lost. I was afraid I would have to chop off my waist long hair with all the hair loss. But I am so happy to report that these wonderful blends have saved my hair and the 3 years that I have dedicated to growing and caring for it.

    I also wanted to talk about Niagra. I’m 34 years old and have always had issues with irregular menstrual cycles. Early on they diagnosed me with PCOS. However, recently, with blood work they couldn’t really determine if that was the cause. I could go even 6-8 months without a period. I also started taking Niagra early in January. I was amazed that shortly after this I had a menstrual cycle, and then 34 days later another! No cramping, no pain, just a minor discomfort which I appreciated to know it was coming. I am so wowed at how fast this acted on regulating my cycle. I’ve felt great and will continue to take this.

    I am taking other blends, like Trinity and Luteolin at nigh and my sleep has been wonderful. I truly recommend all the blends!

  10. Qaz –

    Ok finally I get to do a review! I discovered interstellar blends 3 months ago when I was searching about a certain herb. At first I thought this website was too good to be true but I looked at the hundreds of good reviews and also the reviews people have left on Facebook and I knew I had to give this a try. Now I am lucky to have great hair genetics in my family both sides of my family have a great head of hair and my dad who 52 still has a full head of hair. For me sadly I still have my full hair of hair but my scalp gets oily in one day which makes my hair brittle and fine. I’ve been taking the super hair tonic for only 3 weeks along with pine pollen and OMG, the greasy hair hasn’t gone completely yet but There’s a big improvement and it’s only been 3 weeks! Not to mention how much energy pine pollen gives me as its such a powerful super food. It’s best to take both of them together in warm water. Looking forward to trying your other blends Thank you so much a Gavin !!!

  11. Nick K –

    I’ve been taking the super hair blend as well as the spice & peel blends for about a month now.
    Im impressed with the ingredient list, first and foremost. I’ve tried everything from pills to masks for my hair, and nothing comes close to this ingredient profile.

    The flavor is amazing, similar to a herbal tea.
    Mixing it with the Spice and Peel makes it that much better. I make it with hot water and drink it first thing in the morning.

    Since taking it, I’ve noticed an increase in both thickness and shine. I’m in the process of growing my hair out, and this is one step I now realize I need to get my hair where I want it to be. I’m excited to see the progress continue over the next few months, pairing the blends with fasting and an antioxidant based diet.

  12. anil badhan –

    Amazing product, worth every penny! From the first tea I made, I felt amazing and gave me some goosebumps. The guys sent me sample of trinity also, which i combined both herbs together which made the experience way better and will be purchasing trinity next!

    After few days using the herbs, I noticed how shiny my hair got. Every time I had a shower, my hair used to fall out, during and drying it. I’ve tried so many shampoos, conditioners, hair masks and oils to prevent the hair loss. This product is the best by far that I have used for hair loss.

    I would recommend this to anyone with hair problems (one guy has already placed an order). Super happy how things are going and can’t wait to see the results at the end of the herbs. 100% returning back to buy more herbs! Thank you guys ! Cant wait to try new herbs! Life time customer !

    Enough Love

  13. Gloria Ho –

    I love this blend. It is so easy to take this with any of my drinks twice daily. As of today, I have used the product for two weeks and have noticed a change in my hair and scalp. I do hard labor, so I sweat often and at the end of the night, I feel that my scalp is dry and itchy. When it does, hair falls out. I have tried numerous products and nothing works as well as this blend.

    Since using the super hair formula, I’ve noticed my hair have stopped falling out. In addition, I’ve noticed that the necessity of my hair to be washed is less frequent because I do no experience scalp dryness or itchiness anymore. I know that washing my hair every day induces the falling out of hair, and since using this product, I can now wash my hair less frequently as well as seeing less hair fall out of my head. I really love that I can see the results right away and don’t have to take multiple pills a day in hopes that my hair would grow out. I’ve also noticed a bit of hair growth, and see baby hairs growing where there was an area in my hairline receding.

    This formula is super easy to take. Every morning I mix it with my coffee and drink it easily and it does not leave a bad aftertaste. It really blends well with coffee. I also take it later in the day with any drink and I like that after today, I can reduce the intake amount. I’m very happy I got this blend and that it’s actually working. You come so many products that advertise online and promise you hair growth and you purchase it for ridiculous amount of money and subscribe to them, taking them over the.months without seeing results. With this super hair formula, I was able to feel and see the results almost immediately and am speechless with the end result.

    I will definitely be a returning customer and continue to use this product alongside Pine Pollen which I also bought. This prevents hair loss and replaces so many products such as pills, shampoos, conditioners, and other home remedies I’ve tried. It is by far the best hair loss product I’ve ever used. Thank you to Interstellar for the research and effort that they have put into in order to create such a fantastic blend for hair. I can’t wait to try the other blends. I’ve also got the Triinity, Thermo, and Supernova blends, and they are fantastic as well and helps me with intermittent fasting! Thank you so much for creating this product and finding such a great blend of herbs! I’m excited to get my hair where I want it to be.

    Best Regards! You’ll be hearing from me soon with additional purchases! Fantastic work you’ve done here!

  14. Nirali –

    First thing First, Interstellar blends are a game changer. I ordered Super Hair Tonic and have been taking it for about 3 weeks now and I can already see the difference.I have Wavy curls, and my hair were pretty well until I moved to Canada. After moving to Canada, I started experiencing grey hair, Hair-Fall, low hair volume and my hair started to break very easily. I tried so many supplements and hair care products but all in vain. I was so frustrated and stopped caring about my hair at all.
    Then my friend introduced me to Interstellar Blends. I reached out to Gavin and he recommended Super Tonic Hair. I was very skeptical at first as everything i’ve tried until now had shown no result but I thought of giving it a try. The order came in just few days of ordering it. I have been taking the Super Tonic Hair for 3 weeks and I can literally see the difference in my hair. They are now getting longer, less hair-fall and I can also see new hairs growing. And its not just about the hair but after I started taking Super Tonic Hair, my whole body feels so different, Very light and always at ease. This blends are really life changing and I can’t thank Gavin enough for creating this blend. He is very knwoledgable and answers any question that I have right away. The Customer service is very SPOT-ON.
    Over-all I am very happy with the result and I am really glad that I gave interstellar blends a try. I can’t wait to explore other blends and reset my body.
    I have just become the lifetime customer of Interstellar Blends.

  15. jennifer –

    I have always had good hair, thick and wavy. but it doesn’t seem to grow much past shoulders. And despite having a good diet and pampering my hair with ‘good ” hair products, it would still get a bit dry and frizzy… after a month of using the Super Hair Tonic, my hair grew, I’m seeing new hair growth and its not dry. It looks thick and nourished. the best its ever looked and other people are noticing too… but its not just about my hair…. I feel better in general. This is the first blend bought. I’ve since bought Trinity, Nebula and have received samples of seven sages and super nova.. all amazing. I never want to be without these products. I love how I feel on them… sometimes I fast with them… but even when I don’t. I still feel the positive effects of the blends.

  16. S.R. –

    Where to begin…. I have fasted, both wet and dry, for years prior to coming across Interstellar Blends over a year ago. Like most, I lurked and read testimonial after testimonial wondering if there was actually truth to what I was reading. I am a great lover of science, so Gavin’s website was a treasure trove for me. There was article upon article convincing me that the testimonials I was reading could actually be true.

    I reached out to Gavin and he quickly responded to my inquiry. That alone spoke volumes about his integrity. I then placed an order and received it within a couple of days. The packaging was SUPERB! It was so beautiful that I didn’t even want to open it out of fear of messing it up, but boy am I glad I did.

    I was never a fan of coffee because it gave me the jitters, but I still followed the instructions. The blends tasted horrible so I quickly became grateful for the coffee that helped mask the taste. Within a few minutes, I started to feel different. There was something happening, but I wasn’t sure what or how to explain it. I was feeling an “opening” going on in my chest and head. Soon, my body began to crave the blends, nasty tasting and all!

    I have already tried most blends, but I want to focus on Super Tonic Hair and Pine Pollen. As I mentioned previously, I was no stranger to fasting; and as most would know, that usually means hairloss. My hair had become so thin and brittle that I felt it was a lost cause. I began taking Super Tonic Hair and Pine Pollen, and within a month, I began to get compliments on my hair’s fullness and shine. I no longer had to choose between fasting and my hair. With Interstellar Blends, I can have it all!!

    Thank you Gavin for sharing your wealth of knowledge and your products with the world. You and your whole team are positively impacting and changing lives worldwide!!!

  17. Kevin –

    After I noticed my hair thinned out really quick I decided to order super tonic hair, I was like: nothing to lose right, so why not try it out? After a week I immediately noticed my hair didn’t fall off easily anymore and I’m just a week in!

    Also I noticed that beside growing back thicker and less falling out that the quality became better. Also it tastes really good! Like a light version of coffee which makes it part of my morning routine.

    Can’t wait for what the coming months will bring, but I sure do now that I will order now right away another one.

  18. Bal Purewal –

    I feel very blessed and grateful that i started taking super hair tonic 4 weeks ago. To be honest – it was not my hair that was a priority for me as i have other issues to deal with. However , I purchased the combo pack of blends ( thought that was my best way forward to take all the blends as per Gavins 22:2 protocol . Like i said at the beginning – my hair was not really my main priority for now – main reason being i fell out with my hair 30 years ago when i got my first grey hair (i was 13 years old) – i knew this wa genetic as my family members also started going grey as children – by the time i was 27 years old i succumbed to dying my hair ( so next 24 years was a big commitment to dying my hair every 4 weeks) , in that time – i knew the hair dyes were no good – toxic and carcinogenic – i kept dying my hair as could not leave my house if i saw one white hair!!!! Then we had the first lockdown March 2020- and thats the ush i needed to stop dying my hair – however – i felt that the damage had already been done to my hair – it was thin – lacked lustre and i had over the years developed 2 very very thin (almost bald ) patches on my hairline (above my temples ) which i felt i had to accept as never grew back- Now back to the super tonic hair – started taking 4 weeks ago – one quarter teaspoon once a day only – and my hair seems to have thickened considerably – the bald patches do not look as bald anymore and I’m feeling so much confident with my hair and not afraid to go out . At this time of writing this review- i personally not sure if my grey hairs are reducing and my natural colour coming back ( it appears like it is) – i will write another update in couple months time . Needless to say i have now purchased a 100g bag – without batting an eyelid – i would advise anyone who cares about their hair – STOP GOING TO THE HAIR DRESSERS – DONT ALLOW CARCINIGENS IN HAIR DYES-AND HAIR PRODUCTS ANYWHERE NEAR YOUR SCALP AND HAIR – THE MONEY YOU SAVE NOT GOING TO HAIRDRESSERS WILL BE MORE THAN YOU NEED FOR THE SUPERTONIC HAIR – you will never go back – for the first time in my life – i love my hair – even the greys – i call myself the OCEAN PRINCESS

  19. Suzanne Kici –

    I have been using this product for approximately 12 months and I cannot believe how healthy my hair is. My stylist said that it is so much thicker and has more volume and is not dry like it used to be. I absolutely love this product!

  20. Valerie Cade –

    As a woman who is 53 with thinning hair due to menopause hormonal issues, Super Hair Tonic truly restored my thinning hair to the fullness I’d experienced before ~ and within on week. My mistake was only ordering the sample; I now realize ordering the full package is the key as this blend is a staple for me moving forward (along with peel and spice for every day muscle aches and pains; these are gone, trinity for focus and motivation and autophagy for controlling hunger as I continue to lose weight and not have any cravings). Super Hair Tonic exceeded my expectations!

  21. Harry Aplin –

    I’ve been using this product for the last two weeks and I’m very impressed.. it took about 5 days for me to notice a change, with the strands of my hair looking much thicker and healthy..after a couple of weeks I noticed my eye lashes got really long too! I’ve never seen them so long before!

    I used to suffer from an itchy scalp before using this product but now it feels so good to be free of that, super happy with the results and will be buying more for sure, also keen to try out some of the other products!
    Thankyou Gavin!

  22. Patricia –

    I’ve been taking the blends for over a year. LET ME TELL YOU, these are by far the BEST thing I stumbled upon. I have always been into alternative medicine and am never willing to take what big Pharma is pushing on me. I am a retired Registered Nurse and have pushed back against Pharma my entire career…weird right but my eyes were opened.

    I have suffered with arthritis, pain, low energy but feeling of impending doom, thinning hair, and high blood pressure. Let me tell you….I tried many supplements to try and reverse these symptoms and nothing worked. Again by the Grace of God, I came across Gavin and his life saving blends. What a game changer!!

    Here’s my results. By taking Peel and Spice for Arthritis, I have function back in my wrists and pain is under control. Low Energy and impending doom? GONE with NEBULA and TRINITY…I have never felt so calm and let things pass in my entire life! I use to be high strung and everything effected me. After having what I think was COVID..(never got tested) I started loosing my hair. How disturbing to me. I have been taking the hair blend and is thankfully growing back. Last but not least, EKG has brought my blood pressure into normal range. At every annual physical, my blood pressure was so high sometimes they didn’t want me to leave the clinic. This is a game changer for me. So happy I’m not in the critical zone anymore.

    I could go on and on about the blends. Purge, Glucose Blocker, Anti Adipogenic, Thermo, and Autophagy for loosing weight…OFF THE CHARTS. I lost 10 pounds and have kept it off for over a year.

    This is getting long so just try them….you’ll never go back! Thank You Gavin so much for your life saving and beautiful blends. They are filled with Love.

  23. Kristina –

    I have been taking super hair formula for 2 months now. I bought it to mainly help with gray hairs. I am 33 but started getting grays in my late 20’s. My hair has also been thinning and not growing past a particular length. I did not notice results the first 2 weeks, but kept taking the blend since I had it I figured I might as well finish it off. In the 3rd week, I noticed this bump/wart I had at the nape of my hairline disappeared. It had been there for as long as I can remember. I was shocked to run my finger where it used to be and feel smooth skin. I felt encouraged.

    I have been wearing tape-in extensions for about 2 years to give myself the appearance of longer, thicker hair. 6 weeks in of taking the blend, I had a routine hair appointment to remove, clean my extensions, re-install them, and get my roots colored. As my hair stylist was removing them, she commented on how much new growth she was seeing. When she finally removed them all, we were both shocked to see my actual hair had grown as long as the extensions!!!! This has never happened before! My hair was also so much thicker. She only installed half as many as I used to get, and for my next appointment in a couple weeks, I am going to remove them altogether.

    I have not yet noticed an improvement with the grays, but I think I will be able to analyze results better once I take my extensions out and take a break from hair coloring. I think it may just take longer to see that change, but I feel encouraged because of the amazing results in length and thickness. I will update after a few more months on the improvement of grays! This is a wonderful blend but it takes a few weeks to see the results. Do not be discouraged if you don’t see a change right away! Stick with it and be consistent.

  24. Diana Ricco –

    Super Tonic Hair is a life saver!!! I was starting to lose my hair in clumps after I had covid. Not a single remedy worked to stop the hair loss, let alone grow it back. I was super thinned out and I couldnt even pass a comb through my hair without losing a bunch of it. Enter this blend!

    Within a month of taking it, i was sprouting fresh new hairs all over my head. My existing hair felt stronger and less brittle, AND i havent seen any random strands of grey hair since I started taking this blend. I am a repeat customer already and its been about a year now. My hair is thicker than before. It is stronger than before. It feels and looks way healthier than before.

    Even my hairdressers are shocked by the drastic change in thickness and hair growth that theyve all been asking me for the name of this blend. They tell me they have NEVER seen anything like the results theyve seen on me, and they see people’s hair every day. It is truly life changing. It brought me from being stressed and depressed to being confident agian. I dont think I will ever not buy this blend for as long as I live. Thank you, Gavin.

  25. Konstantin K –

    One month ago I placed my first order and boy was I not disappointed! First of all, I can feel all of them, each has a very pronounced effect. Supernova makes me super focused and alert, gainz significantly increases my muscle mass and strength, the rest just make me feel better in general. I’ve been experimenting with all sorts of different supplements and practices over the last 2-3 years but I have never felt such prominent effects.

    Although, in this review I’d like to particularly highlight Super Hair. I’ve been dealing with slowly receding hairline since I was 20. I started fighting it right when it started, doing all sorts of things from natural toos like microneedling and rosemary oil to more kind of pahrma things like minoxidil. Last few years even though I’ve been doing a lot, the receding hairline started to win the battle. I’ve been seriously thinking about doing hair transplant in the next couple of months.

    Hard to put in words how amazed I was with the results I got from Super Hair. Never have I ever seen such a FAST and PRONOUNCED effect. One week in I could see new hairs growing and old ones getting thicker. No other hair solution or compound works that fast. Minoxidil takes around 8 weeks to see the first tiny results. Hats off to Gavin for creating such a powerful and natural solution. 👏👏👏

  26. Lori Cramer –

    I have been using this blend a little over a month, so I can’t give a full review as yet but I am liking what I see. Fuller thicker hair ..i definitely see a difference from before. So im pretty excited to keep using and see more results. I am definitely excited to try other blends.

  27. Jennifer W –

    It’s funny how you get used to feeling a certain way so that’s just what you accept of yourself. Or you aren’t aware that something is wrong with you until you feel better. I didn’t realize how exhausted I get during the day. I didn’t realize how low energy I am. I just go through my day and anxiously await a proper time to go to bed. Or…. what’s it feel like not to have a headache? I don’t get migraine headaches, it’s just from not sleeping. I can expect a headache at least four times a week. Stomach aches from poor digestion are awful too. Just overall feeling good… really? Yes!!! Yes!!! Yesssss!!!!

    Interstellar Blends to the rescue. So I have several of the blends in sample size. I’ve actually had them quite a while and I would take some here, take some there. I really got serious about it this past week and I have taken them at least twice daily and sometimes three times daily. WOW is all I can say. The blends certainly have a way of pointing out just how poorly I felt by making me feel amazing!!

    I have been taking a concoction of plush, nebula, super hair, spice, niagra, super nova, and several more. The first thing I noticed was that I can actually breathe through my nose. I have absolutely no congestion. I suffer with seasonal allergies and allergens from indoors. I work in an over 100 year old building and there’s stuff everywhere in there. I have zero congestion and zero allergy symptoms.

    Energy? Ha!!! I’m freaking annoying because I have so much energy. Sleep and blends!! No more headaches. Not a single one this week. An overall mellow mood and I’m nice. I’m so, so nice now!!! LOL Digestion issues gone!! When I take steps to feel better I don’t want to put the crap in my body so I’m eating a better diet too. I’m fasting and taking the blends with coffee or tea.

    The blends go above and beyond what they’re intended to help you with. All this and I haven’t even tried the blends for sleep. Since I’m headed into the weekend I will give that a shot…just so I can adjust the amount so I will get up in the morning for work when Monday rolls around.

    The Interstellar Blend website is so amazing. I love the updated “choose your own symptom” scrolling technology provided. It makes choosing blends so convenient.

    Thank you Gavin and Interstellar Blends. I haven’t felt this good in a very long time…. Possibly ever!!

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See What Others Have To Say

“Gavin…you are Truly one AMAZING MAN!! You have a heart of gold and the fact that you just want to help people without any bullshit selling tactics and stupid lies about your products just to get money from people is even more of a reason to know what you’re selling is the real deal as it sells itself!! You are a man of your word and people like you are hard to find these days!! I love that old fashioned bit in you…a good solid handshake means just as much to you as a 300 page contract!! Rock on Gavin…you’re a SUPERSTAR!! You mean what you say and you say what you mean! You’re a straight shooter and people (including myself) love that!!”

Sandra Hale

5.0
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“Mixing my blends up for the morning, got me reminiscing about the first time I took my blends. Man, I was going through Rough Times and, while I always know the reason for these thoughts is that I’m ready to die to who I’ve been being, I was going through some Really Rough suicidal ideation and for the first time felt comfortable with the way it would have happened. It had been going on for several months since I visited family and picked up whatever entity is attached to my brother. Thank God that Gavin was put in my life. From the first mug of blends, It was like that fog got lifted off me and I was thinking, feeling, seeing, knowing, breathing, clearly again. It brought my bliss on almost immediately.

After my first order I knew I had to put in another order to fill in some gaps. At the time I had money to invest and knew I had to invest into myself. I’m glad I did. Over two orders I put in around 2 grand. This was back in August. Between me and my cousin, since then, there is still an abundance of blends. I’m only now starting to run out of a few key blends samples, with strategic dosing. Blends hands down saved my life.

Thank you Gavin and family.”

Carson F

5.0
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We’ve experimented with nearly every product available at this store. Thermo has become a must-have for both my partner and me, serving as our go-to fat burner. What sets Thermo apart is its ability to achieve the effects of fat burners, but with enhanced effectiveness and without any jittery sensations.

The warming sensation it provides is quite noticeable. Thermo truly lives up to its name, seemingly melting away excess weight, especially around our midsections. After taking a break for a few months and noticing some return of fat due to dietary choices, we resumed Thermo use. The results were swift – within about two weeks, combined with Seven Sages and Trinity, our clothes fit more comfortably. Even a month into the routine, we continue to see positive changes, steadily slimming down.

One aspect we appreciate about Thermo is the comforting warmth it imparts, making cold weather more enjoyable. I’ve found myself skipping the morning jacket routine for work, thanks to the cozy warmth Thermo provides. Remarkably, it doesn’t become uncomfortably hot, even in warmer weather. During a recent family trip to Florida, we continued our Thermo regimen, enjoying the sun and beach without missing a beat.

My partner and I have grown to truly relish the warming effects of this blend, which stands out even when combined with other blends. Thank you, Gavin, for a product that has genuinely made a positive impact on our well-being!

Nikita Petko

5.0
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“It’s funny how you get used to feeling a certain way so that’s just what you accept of yourself. Or you aren’t aware that something is wrong with you until you feel better. I didn’t realize how exhausted I get during the day. I didn’t realize how low energy I am. I just go through my day and anxiously await a proper time to go to bed. Or…. what’s it feel like not to have a headache? I don’t get migraine headaches, it’s just from not sleeping. I can expect a headache at least four times a week. Stomach aches from poor digestion are awful too. Just overall feeling good… really? Yes!!! Yes!!! Yesssss!!!!

Interstellar Blends to the rescue. So I have several of the blends in sample size. I’ve actually had them quite a while and I would take some here, take some there. I really got serious about it this past week and I have taken them at least twice daily and sometimes three times daily. WOW is all I can say. The blends certainly have a way of pointing out just how poorly I felt by making me feel amazing!!

I have been taking a concoction of plush, nebula, super hair, spice, niagra, super nova, and several more. The first thing I noticed was that I can actually breathe through my nose. I have absolutely no congestion. I suffer with seasonal allergies and allergens from indoors. I work in an over 100 year old building and there’s stuff everywhere in there. I have zero congestion and zero allergy symptoms.

Energy? Ha!!! I’m freaking annoying because I have so much energy. Sleep and blends!! No more headaches. Not a single one this week. An overall mellow mood and I’m nice. I’m so, so nice now!!! LOL Digestion issues gone!! When I take steps to feel better I don’t want to put the crap in my body so I’m eating a better diet too. I’m fasting and taking the blends with coffee or tea.

The blends go above and beyond what they’re intended to help you with. All this and I haven’t even tried the blends for sleep. Since I’m headed into the weekend I will give that a shot…just so I can adjust the amount so I will get up in the morning for work when Monday rolls around.

The Interstellar Blend website is so amazing. I love the updated “choose your own symptom” scrolling technology provided. It makes choosing blends so convenient.

Thank you Gavin and Interstellar Blends. I haven’t felt this good in a very long time…. Possibly ever!!”

Jennifer W

5.0
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Where do I even start? One of the most…actually YES the most trustworthy, beautiful companies EVER! If you want to improve your life, check out interstellarplan.com. I’ve been through many blend samples before and will soon be placing as big an order as possible of the full size blends.

Samples I have tried are AUTONOMOUS, NEBULA, REWIRE, VICTORIOUS (haven’t been sick all winter and I always get sick), TRINITY, and one I just received a few days ago, HYPNOTIC, all wonderful blends. AUTONOMOUS, REWIRE, and NEBULA have helped me excel and have the confidence to excel exponentially, which I never really had. TRINITY, and NEBULA or SUPERNOVA just makes you feel naturally confident and comfortable. VICTORIOUS instantly gets rid of any sickness I feel coming on, not one stuffy nose or cough this whole winter. HYPNOTIC is great because you wake up with ZERO grogginess.

Love these amazing blends and I wouldn’t ever regret buying a single one. Thank you Gavin and Thank you Interstellar team!!

TONY F

5.0
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“I’ve been using the blends from Interstellar for a month now, and the results have been truly astounding. Previously, I struggled with allergies, migraines, poor circulation, and some anxiety. Since incorporating this blends into my routine, I am almost 100% better. The transformation is nothing short of incredible. It’s amazing how something so simple can make such a profound impact on one’s well-being. This blends has truly been a game-changer for me, alleviating multiple health issues I’ve battled for a long time.”

“What sets Interstellar apart is not just their fantastic blends, but the exceptional individual behind the brand, Gavin. His unique way of being and expressing himself adds an extra layer of value to the entire experience. His dedication and passion are evident in the quality of the product and the level of care and attention given to customers. It’s a testament to the fact that in this fast-paced world, people like Gavin are still making a significant difference by offering solutions that truly enhance people’s lives.”

“I am immensely grateful for stumbling upon this incredible work. Interstellar’s blends has not only brought a significant improvement to my health but has also restored my faith in products that genuinely make a difference. This is a brand that doesn’t just provide a product but offers a transformative experience. It’s rare and refreshing to encounter something that not only works wonders but is supported by a team that genuinely cares. I couldn’t recommend Interstellar’s blends enough!”

Elsa Silva

5.0
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“Interstellar Blends has brought to the world the closest thing to a limitless pill that there is. My experience with the blends has been life-changing. I already work out, meditate, practice gratitude, and am generally health conscious and aware, but the blends have unlocked a whole new level. They correct the energy/focus dips that inevitably arise as part of our natural human experience. Simply put, i feel amazing every day. This sampler is a great intro to the blends. It’s lasted me 2 months now, and I’m about to order some more trinity, seven sages, and probably try new ones. Most of the blends are still going to last me another few months at least, so although it seems like a huge investment at first, it’s truly a bargain. I’ve told all of my close friends and family about the blends, as they have truly enhanced my life experience. I would recommend them to absolutely anyone.”

Emilio C

5.0
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“I purchased a sampler pack of Interstellar Blends, and have been enjoying them all and feeling so much better in general. I wanted to write about Nebula in particular, however, because in just a few short weeks of use, it has totally turned my life around. I have suffered from depression for many years, and while I have tried just about every prescription anti-depressant on the market, I have such severe side effects when taking them that none have been successful or sustainable. From wanting to kill myself to hallucinations to terrible physical symptoms, life with the drugs was worse than without them. On my own, I have days where I can function somewhat normally, but more frequent days when I just lie in bed and cry, stare at the ceiling, and wish I could go to sleep and never wake. NEBULA HAS CHANGED ALL THAT. Within a very short window of taking this amazing blend, I feel a rush of calm, focus, and purpose. I have mental and physical energy to take on my day. I am eager to begin my tasks; and in fact look for additional tasks to complete. I feel a sense of positivity towards my life in general as well as specific challenges that previously would have crippled me with stress and worry. I often think to myself “I got this!”, when in the past the negative voice would have whispered, “OMG this will be a disaster”. Peel and spice are doing wonders for my skin issues and joint pain, Autophagy is helping me control my appetite. But Nebula makes me feel human again, and that makes it my MVP!”

Allison W

5.0
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I’m excited to finally be sharing my experience with the blends! Thank you Gavin!!! I’ve always taken a proactive approach to my health, organic eating, gf beef, supplements, etc. I avoid prescription drugs and most over the counter ones when possible, and mostly healthy until this… Summer 2022 started with a bad fall (I face-planted on concrete) in MAY. Thankfully no concussion, broken tones or teeth. In July I got a spasm in my hip that gave me pain more intense than anything I ever experienced. I had no relief sitting, standing or laying I took aspirin and ibuprofen with no relief. I had three acupuncture treatments. I went to a walk in clinic and was given two shots for pain, a few days later an ER visit. They took ex-rays, more tests, another pain shot and prescribed hydrocodone and two other meds. Again no relief so I stopped all the meds by the third day. A GP prescribed gabapentin, which made me dizzy and disoriented. My gut was pretty messed up and I started having a queasy stomach which made me not want to eat.

Chiropractor visits in AUG and SEP started giving some relief. In OCT I had an endoscopy and given another pill, this time for gastritis, which I took for a couple days. I lost about 16 lbs. that I didn’t need to lose. I ordered my first blends in SEP but it was NOV before I began using them. I had so much confusion, stress, and chronic fatigue, feeling washed out and used up before I began my day. For example, after I put a blend in their coffee cup (I was doling out blends to my husband, daughter and myself) I couldn’t remember if I put it in. Did I or didn’t I? Did I do that one already? Plus I was trying to inculcate all of the blends ASAP into coffee, tea, juice, and a smoothie! Between the three of us! Who was I kidding!!! I wasn’t giving us time to test and experience each one or two or even three at a time. I needed to learn the ‘less ir more’ approach! Fast forward to present time. Every morning we all get Trinity, Autonomous, Rewire, and Supernova. Let me start with my husband. He had become very forgetful in the last few months and I was getting frustrated answering the same things over and over. Well let me tell you with these blends he has clarity, focus, he’s relaxed and retains info. I also ordered ALZ and with these four blends, his memory seems to be just fine. How do I know? Because just the other day he said he wanted his coffee black with no blends. I thought okay – no big deal – one day won’t make any difference. The rest of that day he kept asking me the same things over and over – especially regarding times and dates of upcoming appt or what day is it. So… now each day he drinks his first cup of coffee w/o blends and his second cup of coffee with the blends. My daughter started a new job this fall that entails lots of training and a huge manual about 4″ thick. She is learning things super fast and her attitude towards everything regarding this new job and all the training is so positive! She credits the blends with making a difference! I realized another huge AHA moment this past week.

My husband bought me a piano eight years ago for a wedding gift. That piano has been just sitting unplayed ever since I was diagnosed with PMR in 2018. It was a struggle to play because my fingers and my brain were not coordinating or cooperating with the notes on the page. Yea for Trinity, Autonomous, Rewire and Supernova!!! They are also helping me to relax, have more energy and give more heed to mindfulness! I am able to play songs today that I hadn’t played in years and my fingers are hitting the right keys on the sheet music – not perfectly – but better!

Ardis R M

5.0
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“Trinity, ACB, Thermo, Nebula, Luteolin, Anti-Adipogenic, Seven Sages, Super Hair, Autophagy, Senolytic, Shilajit, Peel, Spice, Matcha, Pine Pollen
I ordered the huge combo batch of blends and have been using them for about 2 weeks. In the short amount of time I have been on the blends, I have noticed some pretty amazing changes that has got me excited and looking forward to continued improvements.

I have been interested in fasting for weight loss and other health benefits for some time and have attempted (and often failed) to complete fasts in the past. Two things I am pretty much guaranteed whenever I embark on a fast is extreme hunger/cravings especially in the initial days, and reduced energy. But to my absolute amazement, I have not experienced any of these effects in the last couple weeks since starting the blends. Fasting with the blends is soooo much easier than without. I have experienced zero hunger/cravings or desire to eat, even when surrounded by people eating all the foods I’m not usually able to resist. It’s incredible! This really excites me because for the first time in a long time, I feel confident that with the help of the blends, I will be able to lose the excess weight and finally achieve my weight loss goals once and for all.

The past several months of adjusting to life in a pandemic has been quite the challenge. For the better part of a year, my energy level has been such that I require a midday nap in order to power through the day. But in the last couple weeks since starting on the blends, this has not been necessary at all. On first day I took the blends, it dawned on me at the end of the day I didn’t take a nap. I thought that maybe it was a fluke, but when the same thing happened next day and the next and pretty much every single day I have taken the blends, I knew without a doubt these blends are legit!

I have suffered with bouts of plantar fasciitis over the years. In the last several months, I noticed the pain on the bottom of my right foot begin to worsen, usually when I stood up after being in a seated or lying position for an extended period. Those first steps were so excruciating I would be forced to limp about until it subsided. Well, I’m happy to report that a few days ago it suddenly hit me when I stood up that the pain had vanished! 100% gone in a matter of days! I’m still in shock.
I’m taking a lot of the blends namely Trinity, ACB, Thermo, Nebula, Luteolin, Anti-Adipogenic, Seven Sages, Super Hair, Autophagy, Senolytic, Shilajit, Peel, Spice, Matcha, Pine Pollen. My plan is to load my system for the first few weeks before adjusting as needed. I can’t say with certainty which blend is having which effect, but I am feel confident they are doing my body good overall. I literally haven’t felt this great in ages. I feel grateful and blessed to have access to these life-changing blends – my heartfelt thanks to the Interstellar team.”

Amarachi Olukoga

5.0
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“Gavin i just wanna send you a message and say Thankyou. I’m in the best place mentally and physically that I’ve ever been in, I had a turbulent year at the start splitting up with my girlfriend of 10 years and my parents losing the family business, and car’s due to covid. I’ve been a customer for a long time but I fell off with the fasting and herbs due to all these events happening around me but right now I honestly couldn’t be in a better place. The herbs are 100% what I needed and are why I’ve changed, they are what have sent me on a spiritual path and allowing me to connect deep to my soul and inner child like you preach. I’m so happy and excited to continue this path of enlightenment and growth. Gavin your a real special kind of human being, a genuine real person who cares about others, and I can only wish you happiness, once again I can’t thank you enough! ❤️ By the way I won £827 in casino with the interstellar strategy it does work! 😂🤣👊🏻“

T

5.0
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“I purchased my first Interstellar blends around 2 months ago: Rewire and Nebula.

I have struggled with chronic fatigue and fibromyalgia, lingering symptoms left after dealing with autoimmune issues.

I was intently looking for alternative supplements to help with energy. I didn’t realize that I needed to address the cognitive and physical systems, namely, my nervous system. Plus, my doctor suggested I return to my healthier weight as a way of lessening the stress to my overall health.

My good friend suggested I try Interstellar. I researched the different blends on their site and was so impressed!! As a result of the conditions I have endured, I am extremely sensitive to anything I take in or apply. From the MINUTE I started using Rewire and Nebula, I noticed cravings went away, I was calmer but energized at the same time, I noticed something else — my mind snapped back to attention!! Imagine being in a busy room trying to focus on what one person is saying, to then the room becoming perfectly still, and being able to hear that conversation fully.

I look forward to getting more blends and experiencing the feeling that I have my life back. I am truly enjoying my mental clarity and better yet, I started to lose weight again! Thank you, Interstellar!!!”

Damaris S

5.0
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“I’ve been using Interstellar Blends regularly for almost 6 years now (I bought my first bag of Original blend in 2016!), and have been so consistently impressed by the very noticeable results that I have not gone back! As a little background, I have been heavily into health study and herbalism for about 20 years, and have experimented with herb extracts (especially from the Chinese and Ayurvedic systems) from many companies, always with small to moderate favorable results… however, Interstellar blends blow everything else I’ve had out of the water! I don’t want to wonder if something I’m taking is working… I want to feel it immediately, and see long term results happen in no uncertain terms.

For the first few years I mainly enjoyed Original, Trinity, Seven Sages, Peel and Spice. This year I added in a lot of blends I had not previously tried (or extensively used), including Rewire, Niagra, Plush, Super Tonic Hair, Hypnotic, Nebula (which I had some previous experience with), and Victorious anti viral blend. All of these have been noticeable, but I feel like for my personal needs, the blends that have changed my life the most dramatically in the past several months have been Rewire and Nebula. I have a two year old who is still breastfeeding, and have had sleep issues for the past few years due to pregnancy and then being woken up by a baby/toddler several times per night. Even when she started sleeping better, it was like my nervous system was still wired to jolt awake in the night, and not be able to get back to sleep. I tried many supplements, herbs and food strategies for this, and nothing really made much difference, until I started taking Rewire, especially when I upped my dose from 1/8 tsp once daily to 1/8 tsp twice daily. I started sleeping so deeply and fully, like my nervous system unwound its previous pattern of waking up and feeling wired during the night. I am now regularly having the best sleeps I’ve had in years. The Hypnotic blend is also excellent, and I take it almost every night, but it was Rewire that really changed this pattern for me.

All the blends I’m taking have really improved my mental clarity, energy levels, and “feel good” neurotransmitters. I am not at all overweight, but I have lost a few pounds just because I feel more satiated and functional on less food than before, and am able to fast for longer periods even though I’m still breastfeeding. My body just feels a lot better overall. To elaborate more on the combination of Rewire and Nebula, and why they’ve had such a profound impact on me: overall, I am a very confident person in almost every way. However, I’ve lacked confidence in one specific area — driving a car, especially on highways — for many many years, due to traumatic experiences of having random panic attacks in those situations, which made me lose trust in myself and my body. It has affected me to the point where I lost the ability and desire to drive myself anywhere for many years, which has restricted my freedom/opportunities, social connections, and personal happiness. Once I started taking Rewire and Nebula consistently, I have been retraining myself, ‘rewiring’ my own mental and emotional capability to drive (my physical ability to do it is already great), and have done more driving in the past couple months that I had in the prior ten years! I’m not all the way there yet, but I am making steady progress!

I love these herbs, and feel like they’re my secret weapon!!”

Courtney T

5.0
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“First of all, before this review begins, I need to thank Gavin for creating this company and this community of like-minded souls who are ever searching to better themselves. My journey with interstellar started in 2018; I was skeptical, as I always am with new products with grand promises, but I took the leap with some samples, and I haven’t stopped purchasing these products since that first month of using the blends. I did not have any weight loss or physical needs from the beginning, but I suffered from mild anxiety, which was sometimes debilitating. I was smoking a lot of marijuana, thinking that this was the answer to my anxiousness, but I was wrong. The first blends I went for were Trinity and Seven Sages, and to say they were life-changing is an understatement. After the first week of use, I immediately noticed a shift. I was calm, collected, and just felt how I should have felt all along. It was around the same time I began to reanalyze my life and focus on what I wanted.

I became so laser focused, so confident and so at peace with everything that I could notice peoples auras around me. What I noticed was 95% of the people I interacted with were just in a low vibrating state of being and the contrast between how I felt just blew my mind. I tried pushing the blends on most of them and to no avail; they mostly kept on the same path, so with that said, you need to want to change, and you need to want to better yourself, and then with the power of the blends, you will see the magic happen. Later around 2019, I finally started the 22/2 lifestyle with solid commitment, which was challenging in the first month but worth it, not only for the longevity reasons but for the amount of time-saving I have daily, not worrying about breakfast or lunch. I get to enjoy dinner with my full focus and appreciate it. I’m never tired and I never crash. I can stay for 72 hours straight before I get fatigued.. 3 years later, I am still using the blends and Gavins protocols. I have tried them all, and I currently stack Trinity, Seven Sages, Autonomous, Peel, Spice, Rewire, Leutolin, Super Hair, Shilajit, and Pine Pollen. I have tried all of the others, too, and will probably incorporate them in as well shortly. Stop sitting and waiting around, this stuff is indeed the next level, and if you want to take back your life and be the best you that you can be, then it’s time to jump on the Interstellar Plan and stop wasting more time! However, if you “think” you are happy where you are, don’t even bother because, like anything in life, change takes commitment. I’m glad I leaped; I’ll never look back.”

Dylan E

5.0
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“After experiencing depression, brain fog, lack of motivation, and a broken toe, I realized I needed a change. When I learned about Interstellar Blends, I was shocked to read all the amazing reviews. That plus all the research and support from Gavin and the group, I knew that this was something I needed to invest in if I wanted a change. Then when my husband experienced a persistent cough and knee pain, and my old dog’s legs were going out on her, that clarified even more that we needed to do something fast.

So I decided to invest in our health and get the monthly special because of the value and the variety of blends it has. That works great for me since I’m mixing up different blends for my whole family. Since doing that, we’ve all seen so much improvement. My dog is walking normally again without expensive vet bills. My husband is no longer coughing and has no more knee pain and didn’t even take ANY of the medication from his doctor. And for me, it’s a 180-degree flip on how I’m feeling!

I have ADHD and never liked taking medication, and I feel much better taking blends to combat the symptoms. Doing the protocol has helped me focus like never before, and the brain fog, procrastination, and lack of motivation are all gone- in just 2 weeks! I even got back to working out after being too depressed to even care for my body. I’ve never fasted before, and for someone who loves food (and dare I say was addicted), I believe it’s the blends that helped me focus on my goals and start 22/2 with so much ease. I’ve tried to stick to goals before, but now, it’s like a switch was flicked on!

As an added bonus, I shed some weight that I picked up in this past year of depression. Now, I love the way my pants fit! Even though we got so much healing already from this, I’m not stopping there. I’ll continue to incorporate blends into my lifestyle because this change is too good to ever go back to how it was!”

Tiffany C

5.0
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