200:1 combo 200g $395 save $105
INTERSTELLAR PEEL BLEND FLAVONOID POWERHOUSE
Insulin Sensitivity Restorer/ Diabetes Destroyer
200:1 100g = 300 1/8 tsp servings
20:1 100g = 36 1 tsp servings
*200:1 means it takes 200kg to make 1kg
20:1 special (buy 3 get 4th free) $37.50 each!
Back in stock and shipping now!
Fix the oxidative stress and you fix the insulin resistance. Diabetes is a byproduct of free radical damage. Flavonoids are the most powerful free radical scavengers on the planet. The vast majority of flavonoids are in the PEELS— the part everyone THROWS AWAY! No wonder diabetes and insulin resistance is rampant! Don’t believe me??? Check your blood sugar now and eat some orange peels for a few days and check again and you will see a HUGE improvement.
Thousands of scientific studies here:
“We demonstrate that the pathways for reactive oxygen species (ROS) production and oxidative stress are coordinately up-regulated in both the liver and adipose tissue of mice fed an HFD before the onset of insulin resistance through discrete mechanism. “
FLAVONOIDS LOWER BLOOD PRESSURE
”Flavonoids from all 5 subgroups have been shown to attenuate a rise in or to reduce blood pressure during several pathological conditions (hypertension, metabolic syndrome, and diabetes mellitus). Flavones, flavonols, flavanones, and flavanols were able to modulate blood pressure by restoring endothelial function, either directly, by affecting nitric oxide levels, or indirectly, through other pathways.”
Oxidative stress shortens telomeres
“Telomeres in most human cells shorten with each round of DNA replication, because they lack the enzyme telomerase. This is not, however, the only determinant of the rate of loss of telomeric DNA. Oxidative damage is repaired less well in telomeric DNA than elsewhere in the chromosome, and oxidative stress accelerates telomere loss, whereas antioxidants decelerate it.”
“Co-occurrence of anxiety–depression like behaviors and memory deficits in rats correlates with elevated oxidative stress.”
Oxidative Stress and Anxiety: Relationship and Cellular Pathways
Anxiety is an alarm going off in your brain saying, “Yo!!! Yeah you!!! We got problems!!!”
“High O2 consumption, modest antioxidant defenses and a lipid-rich constitution make the brain highly vulnerable to redox imbalances. Oxidative damage in the brain causes nervous system impairment. Recently, oxidative stress has also been implicated in depression, anxiety disorders and high anxiety levels. The findings which establish a link between oxidative stress and pathological anxiety have inspired a number of other recent studies focusing on the link between oxidative status and normal anxiety and also on a possible causal relationship between cellular oxidative stress and emotional stress. This review examines the recent discoveries made on the link between oxidative status and normal anxiety levels and the putative role of oxidative stress in genesis of anxiety. We discuss the different opinions and questions that exist in the field and review the methodological approaches that are being used to determine a causal relationship between oxidative and emotional stress.”
Oxidative stress, cellular senescence and aging
“Almost a half century ago, the free radical theory of aging proposed that the reactive oxygen species (ROS) is a key component which contributes to the pathophysiology of aging in mammalian cells. Over the years, numerous studies have documented the role of oxidative stress caused by ROS in the aging process of higher organisms. In particular, several age-associated disease models suggest that ROS and oxidative stress modulate the incidence of age-related pathologies, and that it can strongly influence the aging process and possibly lifespan. The exact mechanism of ROS and oxidative stress-induced age-related pathologies is not yet very clear. Damage to biological macromolecules caused by ROS is thought to result in many age-related chronic diseases. At the cellular level, increased ROS leads to cellular senescence among other cellular fates including apoptosis, necrosis and autophagy. ”
Excessive caloric intake acutely causes oxidative stress
“These results suggest that the initial event caused by overnutrition may be oxidative stress, which produces insulin resistance, at least in part, via carbonylation and oxidation-induced inactivation of GLUT4.”
Oxidative stress and metabolic disorders
“Increased body weight and metabolic disorder including insulin resistance, type 2 diabetes and cardiovascular complications together constitute metabolic syndrome. The pathogenesis of metabolic syndrome involves multitude of factors. A number of studies however indicate, with some conformity, that oxidative stress along with chronic inflammatory condition pave the way for the development of metabolic diseases. Oxidative stress, a state of lost balance between the oxidative and anti-oxidative systems of the cells and tissues, results in the over production of oxidative free radicals and reactive oxygen species (ROS). Excessive ROS generated could attack the cellular proteins, lipids and nucleic acids leading to cellular dysfunction including loss of energy metabolism, altered cell signalling and cell cycle control, genetic mutations, altered cellular transport mechanisms and overall decreased biological activity, immune activation and inflammation. In addition, nutritional stress such as that caused by high fat high carbohydrate diet also promotes oxidative stress as evident by increased lipid peroxidation products, protein carbonylation, and decreased antioxidant system and reduced glutathione (GSH) levels. These changes lead to initiation of pathogenic milieu and development of several chronic diseases. Studies suggest that in obese person oxidative stress and chronic inflammation are the important underlying factors that lead to development of pathologies such as carcinogenesis, obesity, diabetes, and cardiovascular diseases through altered cellular and nuclear mechanisms, including impaired DNA damage repair and cell cycle regulation. Here we discuss the aspects of metabolic disorders-induced oxidative stress in major pathological conditions and strategies for their prevention and therapy.”
Acute oxidative stress and the ketogenic diet
“The mechanisms underlying the efficacy of the ketogenic diet (KD) remain unknown. Recently, we showed that the KD increased glutathione (GSH) biosynthesis. Since the NF E2-related factor 2 (Nrf2) transcription factor is a primary responder to cellular stress and can upregulate GSH biosynthesis, we asked whether the KD activates the Nrf2 pathway. Here we report that rats consuming a KD show acute production of H2O2 from hippocampal mitochondria, which decreases below control levels by 3 weeks, suggestive of an adaptive response. 4-Hydroxy-2-nonenal (4-HNE), an electrophilic lipid peroxidaytion end product known to activate the Nrf2 detoxification pathway, was also acutely increased by the KD. Nrf2 nuclear accumulation was evident in both the hippocampus and liver, and the Nrf2 target, NAD(P)H:quinone oxidoreductase (NQO1), exhibited increased activity in both the hippocampus and liver after 3 weeks. We also found chronic depletion of liver tissue GSH, while liver mitochondrial antioxidant capacity was preserved. These data suggest that the KD initially produces mild oxidative and electrophilic stress, which may systemically activate the Nrf2 pathway via redox signaling, leading to chronic cellular adaptation, induction of protective proteins, and improvement of the mitochondrial redox state.”
Autophagy as a Molecular Target of Flavonoids Underlying their Protective Effects in Human Disease.
“Autophagy is a cellular pathway with the ability to maintain cell homeostasis through the elimination of damaged or useless cellular components, and its deregulation may initiate or aggravate different human diseases. Flavonoids, a group of plant metabolites, are able to modulate different molecular and cellular processes including autophagy.
Analyzed publications indicated that imbalance between cell death and survival induced by changes in autophagy play an important role in the pathophysiology of a number of human diseases. The use of different flavonoids as autophagy modulators, alone or in combination with other molecules, might be a worthy strategy in the treatment of cancer, neurodegenerative disorders, cardiovascular diseases, hepatic diseases, leishmaniasis, influenza, gastric ulcers produced by Helicobacter pylori infection, diabetes, asthma, age-related macular degeneration or osteoporosis.”
When you turn off RLIP76 in mice they can’t get cancer, diabetes or become obese.
2-Hydroxyflavanone inhibits RLIP76 and can be found naturally in parsley, onion peels, berries, tea, and citrus fruit peels.
RLIP76 inhibition (via FLAVONOIDS IN orange peel) prevents Obesity, Metabolic syndrome and cancer
“Feeding a Western high-fat diet (HFD) to C57BL/6 mice induces obesity, associated with a chronic inflammatory state, lipid transport, and metabolic derangements, and organ system effects that particularly prominent in the kidneys. Here, we report that RLIP76 homozygous knock-out (RLIP76−/−) mice are highly resistant to obesity as well as these other features of metabolic syndrome caused by HFD. The normal increase in pro-inflammatory and fibrotic markers associated with HFD induced obesity in wild-type C57B mice was broadly and nearly completely abrogated in RLIP76−/− mice. This is a particularly striking finding because chemical markers of oxidative stress including lipid hydroperoxides and alkenals were significantly higher in RLIP76−/− mice. Whereas HFD caused marked suppression of AMPK in wild-type C57B mice, RLIP76−/−. The baseline renal function was reduced in mice had baseline activation of AMP-activated protein kinase, which was not further affected by HFDRLIP76−/− mice as compared with wild-type, but was unaffected by HFD, in marked contrast to severe renal impairment and glomerulopathy in the wild-type mice given HFD. Our findings confirm a fundamental role of RLIP76 in regulating the function of obesity-promoting pro-inflammatory cytokines, and provide a novel mechanism for targeted therapy of obesity and metabolic syndrome.”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743508/
“When you get rid of this [RLIP76] gene in a mouse, it would appear that the mouse can’t get obese, it can’t get diabetes, it can’t get high cholesterol and it can’t get cancer,” explained Sanjay Awasthi, M.D., professor in the Division of Molecular Diabetes Research at City of Hope hospital.
RLIP76, a Glutathione-Conjugate Transporter, Plays a Major Role in the Pathogenesis of Metabolic Syndrome
Our recently published studies demonstrate that RLIP76−/− mice used for these studies were found to have marked insulin-sensitivity, and blood glucose was 46% lower than in RLIP76+/+animals (p<0.001). RLIP76−/− mice also had lower total serum cholesterol and triglycerides (43% and 40% of control, respectively; p<0.01) [1]. The hypoglycemia in RLIP76−/− mice is particularly remarkable because markers of oxidative-stress are remarkably increased in the tissues of the RLIP76−/− animals [1], [23]–[25]. Thus, in the absence of RLIP76, increases in these lipid-peroxidation products are insufficient by themselves to turn on any signaling pathway that can increase BG or lipids. Increased gluconeogenesis was particularly remarkable given that the activity of key gluconeogenic enzymes, G6Pase, F1,6-BPase, and PEPCK, in liver of RLIP76−/− mice was significantly inhibited.
Enhanced basal pAMPK levels in RLIP76−/− mice was another salient finding which strengthens the postulate that RLIP76 is a highly effective target for developing interventional strategies for MSy. Resveratrol, commonly used anti-oxidant, is known to activate AMPK which could contribute to its protective effects from high fat diet induced insulin-resistance [53], [54]. AMPK protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. AMPK is activated by phosphorylation by an upstream protein kinase known as AMPK kinase. Activated AMPK can phosphorylate and regulate in vivo HMG-CoA, which is key regulatory enzyme of sterol synthesis [43], [47]. HMG-CoA limits the rate of cholesterol synthesis in liver tissue. Lipitor, inhibitor of HMG-CoA, exerts anti-inflammatory effects by lowering plasma cholesterol. Activation of AMPK leads to the inhibition of cholesterol synthesis by the phosphorylation of HMG-CoA reductase [43]. Loss of RLIP76 significantly affects the activation of stress and apoptosis pathway proteins [1], [25], [35]. Activation of AMPK leads to the inhibition of cholesterol synthesis by the phosphorylation of HMGCR. AMPK activation would be a good approach to treat T2D. These medications generally function to increase the effectiveness of insulin-mediated postprandial inhibition of hepatic gluconeogenesis. These findings provide a new insight on the mechanisms of action of hypoglycemic and/or hypolipidemic drugs.
RLIP76 knock-out mice survive well and are active. In our extensive and previously published studies, RLIP76 inhibition specifically leads to targeting signaling of importance in diabetes mellitus and other oxidative stress related conditions like cancers where targeting RLIP76 leads to selective cancer cell death without affecting the survival of normal cells and tissues [1],[31]–[33]. Hence, both global and selectively targeted approaches can be reasonably pursued as required while targeting RLIP76. In conclusion, our results suggest that RLIP76 is a key effector controlled by multiple proteins known to regulate the metabolic abnormalities of diabetes and metabolic syndrome, and that in its absence drugs that target these proteins will fail to function. The specific events that regulate the transport-effector/clathrin-endocytosis activity of RLIP76 (i.e. phosphorylation of RLIP76 by JNK, Akt, AMPK) will be explored in the future studies.
2′-Hydroxyflavanone (a flavonoid in orange peel): A novel strategy for targeting breast cancer
Intake of citrus fruits is known to reduce the risk for incidence of breast cancer. Hence, we tested the efficacy of citrus flavonoid 2′-hydroxyflavanone (2HF) in breast cancer. 2HF inhibited survival, clonogenic ability, cell cycle progression and induced apoptosis in breast cancer cells. 2HF also decreased VEGF levels and inhibited migratory capacity of breast cancer cells. Administration of 2HF led to regression of triple-negative MDA-MB-231 tumors in the mice xenograft model. 2HF decreased the levels of RLIP76 both studies and MDA-MB-231 xenograft model of breast cancer. Western blot and histopathological analyses of resected tumors showed a decline in the levels of survival and proliferation markers Ki67, pAkt, survivin, and cell cycle proteins CDK4 and cyclin B1. 2HF treatment led to inhibition of angiogenesis as determined by decreased VEGF levels and angiogenesis marker CD31 . 2HF reversed the pro-/anti-apoptotic ratio of BAX/BCL-2 by decreasing anti-apoptotic protein BCL-2 and increasing pro-apoptotic proteins BAX and BIM . 2HF also decreased the mesenchymal markers vimentin and fibronectin along with causing a parallel increase in pro-differentiation protein E-cadherin. Collectively, the ability of 2HF to decrease RLIP76, VEGF and regulate critical proliferative, apoptotic and differentiation proteins together provides strong rationale to further develop 2HF based interventions for targeting breast cancer.
It takes about 16 oranges to get a good dose of 2HF. Get the INTERSTELLAR PEEL BLEND instead in either 20:1 or 200:1 concentrations which is like eating that many oranges in just a few small scoops!
AWESOME MADE CONVENIENT!
Rich Ryan –
My Dad has severe arthritis in his back. Could barely walk. 72 years old. History of severe arthritis in family. Had him do 3/4 tsp each of 200:1 Peel and Spice everyday. Made capsules for him so he’d take it. Heard back from him tonight after about a month of taking it, and the pain is gone! Pain Free for the first time in 20 years!
Berenice Kobu –
I’m so grateful for these blends. Not only for myself, but mostly for my mom. I had to take her to the ER on Christmas day because of severe pain. She has DDD, fibromyalgia, arthritis on both knees and has been living with chronic pain for several years. But this time, it was different. She couldn’t walk straight, climb the stairs or even move without crying like a kid. I got the blends for her (Spice, Peel, Trinity and pine pollen) and just after a week, she was already feeling better. She’s not pain free yet, but she looks and feel better; even her depression is under control. Thank you.
Craig Wilson –
From Chronic pain to Pain free, I honestly didn’t really think I’d get there even though I had great experiences with the other blends I just thought being pain free was beyond me. I just put my pain down to 20+ years of over use in the construction industry and that it was just irreversible and something I would have to live with. The best I could get was relative pain suppression with cortisone injections but they come with there own problems and damage further down the line.
My pain was so bad that even basic things like lifting my duvet off myself in the mornings was unbearable with acute stabbing pain in my elbow and wrist, lifting jars or tins out of cupboards, lifting pots and pans all brought the same acute stabbing pain…. fast forward 4 months and I’m now actually pain free and all I’ve done is follow 22/2 intermittent fasting along with peel, spice and I’ve also used Titanium and I can now do all activities without any pain.
Being pain free is something that can be taken for granted until you no longer have that luxury, our bodies can recover from anything if we treat them rite and using Gavin’s blends alongside 22/2 is absolutely the way to go to achieve maximum health and fitness.
Your mind and body deserves the best and Gavin’s blends are the best by far so treat yourself .
Giannina Winter –
These blends are absolutely changing my whole health conditions! I am suffering from psoriasis over years and the peel & spice combo. I would like to recommend the blends to everyone. It is your health and every cent is well invested. I have been hiding for a long time and now i can show my skin again, especially in the summer. I feel good and confident again. In combination with the fasting program you can notice a change in a short time. Many thanks at this point.
Tina –
Wow where do I start. I started taking interstellar blends at the end of 2021 and nothing in words can describe how they have levelled up my mind, body, spirit and changed my life more in more ways than I could ever imagine. Life is just amazing & I am thankful for Gavin everyday. I am completely off all medication & I just love life so much. Before blends, I was pretty much a walking zombie; constantly getting sick , health issues, on and off medication, I yearned to feel ‘normal’ and I can finally say I am at that point right now and more. Let me give you a summary of some of my favourite blends:
TRINITY : Before meeting Trinity I was a complete daily mess of anxiety & depression. I would have several panic / anxiety attacks a day & I still remember waking up with my heart feeling like it was off the charts and completely dreading the day. I didn’t want to do anything, I had such a negative outlook on life & was in constant victim mode. I’ve done a complete 180 on Trinity, she’s made the biggest impact on me & I could never live without it again. I don’t have anxiety anymore & I wake up so excited to welcome what the day holds for me. I am so full of gratitude for being alive, I love life so much! Everyone around me constantly describes me as a ray of sunshine. Trinity has helped me fix my relationship with myself, and of course that trickles into my relationships and daily life.
PLUSH : I am so thankful for Plush as the last medication for me to get off was the contraceptive pill. Like many girls , I was put on it when I was a teenager for acne, supposedly caused by ‘hormone issues’ and had been struggling to get off it for the better part of 10 years. Whenever I tried to get off it, the acne would come back full force , mood swings, my periods super irregular. In May this year, I started on Plush and that was the last time I was on the pill. My acne has NOT come back at all, my periods are regular now, I don’t have any PMS symptoms and I finally feel like my body is a part of me. In a sense I finally feel like myself , I love my body and self now and that’s the best I can describe it. ALSO, I have always looked younger all my life , I am currently 27 and would get mistaken for 20 – 23 all the time. But now new people I meet are shocked I am even over the age of 17- 18! I believe this is because Plush has cleared up old acne scars & sun damage/ pigmentation has also lightened up over the last few months. My face also seems more lifted then it did before Plush as if my skin is producing a lot of collagen again – before Plush I noticed my jowls had began to start drooping, in which I assumed the normal ageing process was starting , but now that’s gone too!
SPICE & PEEL : All my life I struggled with allergies, I felt like my body was allergic to everything that was part of the earth. I was constantly on a cycle of having hay fever, eczema and hives & one day I realised I had none of these… for months which had never happened before. I don’t remember the last time I touched an anti-histamine pill nor be covering myself in steroid cream. I don’t wake up sneezing or with a blocked nose, I don’t come back with rashes anymore when I go hiking or bush walking. Any cuts I get or bruises heals FAST within days. It’s also eliminated all inflammation I would experience from allergies as well.
REWIRE : This has to be my favourite blend on par with Trinity for eliminating distractions. Although never being professionally diagnosed due to my refusal to be on medication, I know I have what they call “ADHD”. Rewire, just shuts down the constant chatter in my mind and makes me get things done! I don’t procrastinate nor zone out anymore, and tasks don’t feel like heavy chores. It has stopped me from thinking about food all the time, kept me on strict 22/2 sometimes even longer, eliminated my shopping and nicotine addiction & I have even become the best performer in my team at work. People are sometimes baffled at how I am so efficient, whilst producing top quality work & how great my attention to detail is sometimes. Anything from time management to money management is great now. I understand new concepts so so easy now – currently undertaking a couple courses & it baffles me how I feel like I’m on the ‘limitless’ pill at times. Things just click!
STOMACH RESET COMBO : And lastly, a homage to Helico , Paraslayer & Purge. To sum it up before introducing this trio, for as long as I could remember, I was struggling with constant food intolerances, insane bloating , gut and digestion issues. Sometimes I would eat & I would automatically throw up, or be in digestion pain for the whole day / night. This trio cured it all. It did take 2 – 3 months or so to clear everything up as my issues were very much in the deep end , but just like my other past health issues, I can’t believe how i am ‘normal’ now. Food makes me so happy now & I am just so grateful I have a beautifully working digestive system now.