Roundworm burden
You want it cleared: hookworm is paid for in hemoglobin, and the blood count came back up once it was gone.
In depth
Roundworms — unsegmented, cylindrical helminths, the group that includes hookworm. One of the three helminth groups counted into parasite burden, and the group its iron evidence is drawn from.
What it drives
It increases Parasite burden.
Taxonomic edge. Roundworms are one of the three main helminth groups infecting humans. Verbatim: “Helminths of three main groups—cestodes (tapeworms), trematodes (flatworms, or flukes), and roundworms (nematodes)—are human parasites responsible for an enormous burden of disease.”. PMC9155875
It reduces Micronutrient status.
Ascaris and hookworm burden produces protein-energy and micronutrient malnutrition in the host. doi 10.1371/journal.pntd.0004193
It increases Allergic signaling.
Nematode infection elicits the canonical IL-4/IL-13 type-2 expulsion response in the gut. doi 10.1038/s41598-024-65281-0
It increases Regulatory T cells.
Chronic nematode infection expands regulatory T cells that suppress bystander immune responses. doi 10.1038/s41467-017-01886-6
It reduces Gut barrier.
Trichuris syncytial tunnelling and Strongyloides invasion breach the intestinal epithelial barrier. doi 10.1371/journal.pntd.0001856
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.