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Pathway

Mast cell enzyme

Mast cell activation marker

Raised When the Heart Is Failing

1 blend on this site modulates it.

Also searched as Mast cell activation marker.

The cell behind hay fever also lives in the heart, and the enzyme it releases contributes to remodeling. Its levels, and mast cell numbers, are measurably higher in failing hearts than in healthy ones.

In depth

Released by mast cells; higher in failing hearts than in healthy ones.

What drives it

Calms histamine response increases it.

The enzyme the mast cell releases, and it remodels the heart. Mast cell tryptase rises in the inflamed heart alongside stem cell factor, and both are suppressed by agents that help (doi 10.1186/1476-9255-7-39 (pmc2922108) — Matsumori a, Yamamoto k, Shimada m. Cetirizine a histamine H1 receptor antagonist improves viral myocarditis, j Inflamm 2010). 'myocardial histamine and tryptase content, and mast cell density ARE higher in heart failure due to idiopathic dilated or ischemic cardiomyopathy than in control hearts'. ⇒ the cell that causes hay fever also helps turn an inflamed heart into a stiff one. doi 10.1186/1476-9255-7-39

What it drives

It increases Supports heart function.

The enzyme the mast cell releases, and it remodels the heart. Mast cell tryptase rises in the inflamed heart alongside stem cell factor, and both are suppressed by agents that help (doi 10.1186/1476-9255-7-39 (pmc2922108) — Matsumori a, Yamamoto k, Shimada m. Cetirizine a histamine H1 receptor antagonist improves viral myocarditis, j Inflamm 2010). 'myocardial histamine and tryptase content, and mast cell density ARE higher in heart failure due to idiopathic dilated or ischemic cardiomyopathy than in control hearts'. ⇒ the cell that causes hay fever also helps turn an inflamed heart into a stiff one. doi 10.1186/1476-9255-7-39

Blends that modulate it

Each blend page names this pathway and carries the study behind its claim.

Myocarditis Antidote (Cardiac Inflammation Resolution) →

See it on the map

Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.

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