Inositol
The Strongest Evidence is in one Place: myo-inositol improves insulin sensitivity and ovulatory function in polycystic ovary syndrome, where it acts as an insulin second messenger. Outside that indication the case is much thinner.
In depth
Myo-inositol and D-chiro-inositol — the backbone of phosphoinositide signaling.
What drives it
Micronutrient status increases it.
Dietary and endogenous synthesis from glucose. Carried by the intermediary-metabolism, micronutrient and clinical reviews. doi 10.3390/nu18132141 · PMC9967593
What it drives
It increases Insulin sensitivity.
Myo-inositol acts as an insulin second messenger. Carried by the intermediary-metabolism, micronutrient and clinical reviews (PMC9967593; doi 10.3390/nu18132141; PMC12673670; doi 10.1016/j.molmet.2023.101755). Verbatim: “Myo-inositol is an upcoming insulin-sensitizing agent, which is a second messenger responsible for insulin-mediated intracellular glucose transport”. doi 10.3390/nu18132141 · PMC9967593
It reduces PCOS.
The strongest evidence is in one place - improving insulin sensitivity and ovulatory function in PCOS. Outside that indication the case is much thinner. Carried by the intermediary-metabolism, micronutrient and clinical reviews (PMC9967593; doi 10.3390/nu18132141; PMC12673670; doi 10.1016/j.molmet.2023.101755). Verbatim: “Inositol is an effective and safe treatment in PCOS”. doi 10.3390/nu18132141 · PMC9967593
It increases Female fertility.
Via the ovulatory arm in PCOS. Carried by the intermediary-metabolism, micronutrient and clinical reviews. doi 10.3390/nu18132141 · PMC9967593
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.