Fullness hormone (PYY)
This is a third separate way that eating shuts fat release down, alongside insulin and the short-chain fatty acids that fiber fermentation produces. It is released particularly in response to protein and fiber. Nothing here is a criticism of eating well — it is simply why the timing of a fat-release product is not a detail.
In depth
A hormone released by the gut after eating that binds the same brake receptor as the stress peptide.
What drives it
Gut barrier increases it.
Distal-gut enteroendocrine L cells secrete peptide YY in response to luminal nutrients. PMID 26258126
What it drives
It increases The Stress Veto.
10.1371/journal.pone.0040038 — from a published diagram titled 'control DE LA LIPÓLISIS EN EL adipocito HUMANO' — a human-specific control map. Its legend enumerates the whole system: 'Receptores β- y α2A-Adrenérgicos (RA); Adenilato Ciclasa (AC); proteínas G heterotriméricas (Gs y Gi); Proteína Cinasa A (PKA); Lipasa Sensible a Hormona (LSH); Receptor de Insulina (IRS-1/2); Proteína Cinasa B (PKB); Cinasa (PI3-K); Fosfodiesterasa tipo 3B (PDE-3B); GUANILATO Ciclasa (GC); Receptor de Péptidos Natriuréticos (NPR-A); Proteína Cinasa G (PKG); Lipasa de Monoglicéridos (LMG); NEUROPÉPTIDO Y (NPY) Y PÉPTIDO YY (PYY); Proteínas que enlazan lípidos en adipocito (ALBP); Ácidos Grasos No Esterificados (AGNE)' (Revista de Educación Bioquímica, UNAM — 'Control de la lipólisis en el adipocito HUMANO' (ESPAÑOL)). A seventh veto ligand, named alongside the sixth in the same legend. Peptide YY shares the same receptor family as neuropeptide Y, and it is a gut hormone released after eating — particularly in response to protein and fiber. That is the third separate mechanism by which eating shuts this system down, alongside insulin and the short-chain fatty acids that fiber fermentation produces. The fasted rule keeps earning itself. doi 10.1371/journal.pone.0040038
It reduces Releases stored fat.
10.1016/S0022-2275(20)39879-5 — 10.1172/JCI114425 — from a published diagram titled 'control DE LA LIPÓLISIS EN EL adipocito HUMANO' — a human-specific control map. Its legend enumerates the whole system: 'Receptores β- y α2A-Adrenérgicos (RA); Adenilato Ciclasa (AC); proteínas G heterotriméricas (Gs y Gi); Proteína Cinasa A (PKA); Lipasa Sensible a Hormona (LSH); Receptor de Insulina (IRS-1/2); Proteína Cinasa B (PKB); Cinasa (PI3-K); Fosfodiesterasa tipo 3B (PDE-3B); GUANILATO Ciclasa (GC); Receptor de Péptidos Natriuréticos (NPR-A); Proteína Cinasa G (PKG); Lipasa de Monoglicéridos (LMG); NEUROPÉPTIDO Y (NPY) Y PÉPTIDO YY (PYY); Proteínas que enlazan lípidos en adipocito (ALBP); Ácidos Grasos No Esterificados (AGNE)' (Revista de Educación Bioquímica, UNAM — 'Control de la lipólisis en el adipocito HUMANO' (ESPAÑOL)). A seventh veto ligand, named alongside the sixth in the same legend. Peptide YY shares the same receptor family as neuropeptide Y, and it is a gut hormone released after eating — particularly in response to protein and fiber. That is the third separate mechanism by which eating shuts this system down, alongside insulin and the short-chain fatty acids that fiber fermentation produces. The fasted rule keeps earning itself. doi 10.1016/S0022-2275(20
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.