Fullness hormone (CCK)
Cholecystokinin
Also searched as Cholecystokinin.
In depth
Cholecystokinin — released by the upper small intestine when fat and protein arrive, it slows the stomach and tells the brain the meal is done.
What drives it
Gut-brain signal increases it.
Bitter taste receptors (T2Rs) comprise a family of 25 G protein-coupled receptors that are expressed in multiple tissues, including enteroendocrine cells (EECs), of the GI tract. 10.1093/ajcn/nqab418. doi 10.1093/ajcn/nqab418
Gut barrier increases it.
10.14814/phy2.70373 — exposure of cultured enteroendocrine cells to promiscuous bitter tastants (e.g. quinine) is known to increase intracellular calcium signaling and stimulate release of hormones, including cholecystokinin (CCK). 10.1093/ajcn/nqab418. doi 10.14814/phy2.70373
What it drives
It increases Curbs appetite.
PMC1382399 — Gut hormones such as cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1) play a role as satiation factors. PMID 27875537 · PMC1382399
It reduces Stomach emptying.
PMC423501 — L-trp at the higher dose stimulates CCK release (p = 0.0018), and induces a significant retardation in gastric emptying (p = 0.0033) ... an effect that could be mediated by CCK. PMID 27875537 · PMC423501
It increases Pancreatic acinar cells.
CCK acts on acinar CCK-A receptors to trigger zymogen granule secretion; supramaximal CCK causes premature intracellular zymogen activation. PMID 40563241
Blends that modulate it
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See it on the map
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