cGMP-making enzyme
Guanylate cyclase
Also searched as Guanylate cyclase.
There is a second road into fat release that shares none of the first road's parts — its own receptor, its own enzyme, its own messenger, its own kinase. It converges on the same lipases at the end. That independence is the point: it still works when the adrenaline road is blunted. It is also close to absent in mice, so animal work on it says little about people.
In depth
A completely separate signal-making enzyme, used by the heart-derived route rather than the adrenaline route.
What drives it
Natriuretic receptor increases it.
From a published diagram titled 'control DE LA LIPÓLISIS EN EL adipocito HUMANO' — a human-specific control map. Its legend enumerates the whole system: 'Receptores β- y α2A-Adrenérgicos (RA); Adenilato Ciclasa (AC); proteínas G heterotriméricas (Gs y Gi); Proteína Cinasa A (PKA); Lipasa Sensible a Hormona (LSH); Receptor de Insulina (IRS-1/2); Proteína Cinasa B (PKB); Cinasa (PI3-K); Fosfodiesterasa tipo 3B (PDE-3B); GUANILATO Ciclasa (GC); Receptor de Péptidos Natriuréticos (NPR-A); Proteína Cinasa G (PKG); Lipasa de Monoglicéridos (LMG); NEUROPÉPTIDO Y (NPY) Y PÉPTIDO YY (PYY); Proteínas que enlazan lípidos en adipocito (ALBP); Ácidos Grasos No Esterificados (AGNE)' (Revista de Educación Bioquímica, UNAM — 'Control de la lipólisis en el adipocito HUMANO' (ESPAÑOL)). The second, entirely separate road. The natriuretic route does not use the epinephrine messenger at all — it has its own receptor, its own enzyme, its own messenger and its own kinase, and they converge on the same lipases. That independence is why it matters: it still works when the epinephrine road is blunted. And it is human-specific — this road is effectively absent in mice, which voids rodent data on it entirely. Sources: PMID 12970365. PMID 12970365
What it drives
It increases Vasodilation signal.
10.3389/fphar.2024.1359939 — 10.1371/journal.pone.0015686 — from a published diagram titled 'control DE LA LIPÓLISIS EN EL adipocito HUMANO' — a human-specific control map. Its legend enumerates the whole system: 'Receptores β- y α2A-Adrenérgicos (RA); Adenilato Ciclasa (AC); proteínas G heterotriméricas (Gs y Gi); Proteína Cinasa A (PKA); Lipasa Sensible a Hormona (LSH); Receptor de Insulina (IRS-1/2); Proteína Cinasa B (PKB); Cinasa (PI3-K); Fosfodiesterasa tipo 3B (PDE-3B); GUANILATO Ciclasa (GC); Receptor de Péptidos Natriuréticos (NPR-A); Proteína Cinasa G (PKG); Lipasa de Monoglicéridos (LMG); NEUROPÉPTIDO Y (NPY) Y PÉPTIDO YY (PYY); Proteínas que enlazan lípidos en adipocito (ALBP); Ácidos Grasos No Esterificados (AGNE)' (Revista de Educación Bioquímica, UNAM — 'Control de la lipólisis en el adipocito HUMANO' (ESPAÑOL)). The second, entirely separate road. The natriuretic route does not use the epinephrine messenger at all — it has its own receptor, its own enzyme, its own messenger and its own kinase, and they converge on the same lipases. That independence is why it matters: it still works when the epinephrine road is blunted. And it is human-specific — this road is effectively absent in mice, which voids rodent data on it entirely. doi 10.3389/fphar.2024.1359939
Blends that modulate it
Each blend page names this pathway and carries the study behind its claim.
See it on the map
Open the causal map to follow this pathway upstream and downstream, arrow by arrow, each with its study.