Urolithin A

Urolithin A is a natural molecule that has been found to downregulate androgen receptor activation and suppress the growth of prostate cancer. It is a metabolite derived from ellagic acid, which is found in various fruits and nuts. Some of the top foods and herbs that contain ellagic acid and can potentially produce urolithin A include:

1. Pomegranates: Pomegranate juice and seeds are rich sources of ellagic acid, which can be metabolized into urolithin A in the gut.
2. Raspberries: Raspberries are another fruit that contains ellagic acid and can potentially produce urolithin A.
3. Walnuts: Walnuts are a type of nut that contains ellagic acid and can contribute to the production of urolithin A.
4. Strawberries: Strawberries are known to contain ellagic acid, which can be converted into urolithin A.
5. Blackberries: Blackberries are also a good source of ellagic acid and can potentially produce urolithin A.

The health benefits of urolithin A include:

1. Anti-cancer properties: Urolithin A has been shown to inhibit cell proliferation and induce apoptosis in various cancer cell lines, including prostate cancer cells. It targets the androgen receptor signaling axis, which is crucial for the growth and progression of prostate cancer.
2. Anti-inflammatory effects: Urolithin A has been found to possess anti-inflammatory properties, which can help reduce inflammation in the body and potentially protect against chronic diseases associated with inflammation.
3. Antioxidant activity: Urolithin A exhibits antioxidant activity, which can help neutralize harmful free radicals and protect cells from oxidative damage.
4. Gut health benefits: Urolithin A is produced by the gut microbiota through the metabolism of ellagic acid. It has been shown to have beneficial effects on gut health by promoting the growth of beneficial bacteria and reducing inflammation in the gut.

1. … emblica L.) Fruits Ameliorate Vascular Smooth Muscle Cell Dysfunction in Hyperglycemia: An Underlying Mechanism Involved in Ellagitannin Metabolite Urolithin A
2. A natural molecule, Urolithin A, downregulates androgen receptor activation and suppresses growth of prostate cancer
3. A Novel Candidate for Prevention and Treatment of Atherosclerosis: Urolithin B Decreases Lipid Plaque Deposition in apoE−/− Mice and Increases Early Stages of …
4. Activation of the miR-34a-Mediated SIRT1/mTOR Signalling Pathway by Urolithin A Attenuates D-Galactose-Induced Brain Aging in Mice
5. An increased autophagic flux contributes to the anti-inflammatory potential of Urolithin A in macrophages
6. Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism
7. Antiaging Effects of Urolithin A on Replicative Senescent Human Skin Fibroblasts
8. Antimelanogenic effect of Urolithin A and urolithin B, the colonic metabolites of ellagic acid, in B16 melanoma cells
9. Antiproliferative activity of the ellagic acid-derived gut microbiota isoUrolithin A and comparison with its Urolithin A isomer: the role of cell metabolism
10. Antiproliferative activity of the ellagic acid-derived gut microbiota isoUrolithin A and comparison with its Urolithin A isomer: the role of cell metabolism
11. Antiproliferative effect of Urolithin A, the ellagic acid-derived colonic metabolite, on hepatocellular carcinoma HepG2. 2.15 cells by targeting Lin28a/let-7a axis
12. Bioactivity screening for xylopic acid, geraniin and its gut metabolites, ellagic acid and Urolithin A, in cell based assays
13. Chemoprevention of endometrial cancer with Urolithin A, a metabolite of berry ellagitannins.
14. Clustering according to urolithin metabotype explains the interindividual variability in the improvement of cardiovascular risk biomarkers in overweight‐obese …
15. Compositions comprising nicotinamide riboside and a urolithin
16. Development and validation of a liquid chromatography-electrospray ionization-tandem mass spectrometry method for the determination of urolithin C in rat plasma …
17. Effects of fruit ellagitannin extracts, ellagic acid, and their colonic metabolite, Urolithin A, on Wnt signaling
18. Effects of Pomegranate Extract on High Fat/High Sucrose Diet induced Obesity are Dependent on the Intestinal Formation of Urolithin A
19. Ellagic acid and its metabolite Urolithin A induce prostate cancer cell death in p53 dependent and independent manner
20. Ellagic Acid and Its Microbial Metabolite Urolithin A Alleviate Diet-induced Insulin Resistance in Mice (OR24-03-19)
21. Ellagic Acid and Urolithin A Improve Insulin Sensitivity in Diet-Induced Insulin Resistant Mice and Reduce Detrimental Effects of Palmitate Administration in …
22. Ellagitannin metabolites, Urolithin A glucuronide and its aglycone Urolithin A, ameliorate TNF–induced inflammation and associated molecular markers in …
23. Ellagitannin metabolites, Urolithin A glucuronide and its aglycone Urolithin A, ameliorate TNF‐α‐induced inflammation and associated molecular markers in human …
24. Enhancement of gut barrier function by microbial metabolite, Urolithin A via AhR-Nrf2 dependent pathways in IBD
25. Genetic Polymorphisms, Adherence to Mediterranean Diet and Microbiota-Associated Urolithin Metabotypes: A Complex Cocktail to Predict the Obesity in Childhood …
26. Gordonibacter urolithinfaciens sp. nov., a urolithin-producing bacterium isolated from the human gut
27. Gut bacterial metabolite Urolithin A (UA) mitigates Ca2+ entry in T cells by regulating miR-10a-5p
28. Gut microbiota conversion of dietary ellagic acid into bioactive phytoceutical Urolithin A inhibits heme peroxidases
29. Identification of Novel Urolithin Metabolites in Human Feces and Urine after the Intake of a Pomegranate Extract
30. Identification of Urolithin A as a metabolite produced by human colon microflora from ellagic acid and related compounds
31. In vitro antiproliferative and antioxidant effects of Urolithin A, the colonic metabolite of ellagic acid, on hepatocellular carcinomas HepG2 cells
32. In vivo administration of Urolithin A and B prevents the occurrence of cardiac dysfunction in streptozotocin-induced diabetic rats
33. In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite Urolithin A
34. Induction of Autophagy and Activation of SIRT‐1 Deacetylation Mechanisms Mediate Neuroprotection by the Pomegranate Metabolite Urolithin A in BV2 Microglia and …
35. Metabolite of ellagitannins, Urolithin A induces autophagy and inhibits metastasis in human sw620 colorectal cancer cells
36. Methylated Urolithin A, the modified ellagitannin-derived metabolite, suppresses cell viability of DU145 human prostate cancer cells via targeting miR-21
37. MOLECULAR MECHANISM OF ELLAGIC ACID AND Urolithin A IN THE SUPPRESSION OF PROSTATE CANCER BY INFLUENCING THE p53-MDM2 PATHWAY
38. Neuroprotective Effects of Pomegranate Juice against Parkinson’s Disease and Presence of Ellagitannins-Derived Metabolite—Urolithin A—In the Brain
39. Neuroprotective effects of Urolithin A on H2O2-induced oxidative stress-mediated apoptosis in SK-N-MC cells
40. Oral delivery of nanoparticle Urolithin A normalizes cellular stress and improves survival in mouse model of cisplatin-induced AKI
41. Orally administered Urolithin A is safe and modulates muscle and mitochondrial biomarkers in elderly
42. Pancreas protective effects of Urolithin A on type 2 diabetic mice induced by high fat and streptozotocin via regulating autophagy and AKT/mTOR signaling pathway
43. Pharmacokinetics and tissue disposition of Urolithin A, an ellagitannin-derived metabolite, in mice
44. Plasma urolithin metabolites correlate with improvements in endothelial function after red raspberry consumption: A double-blind randomized controlled trial
45. Pomegranate ellagitannin metabolite, Urolithin A, inhibits prostate cancer cell proliferation via inhibition of IGF-1 signaling pathway
46. Pomegranate juice metabolites, ellagic acid and Urolithin A, synergistically inhibit androgen-independent prostate cancer cell growth via distinct effects on cell cycle …
47. Pomegranate polyphenols and Urolithin A inhibit α-glucosidase, dipeptidyl peptidase-4, lipase, triglyceride accumulation and adipogenesis related genes in 3T3-L1 …
48. Process-scale synthesis of Urolithin A
49. Protective effect of Urolithin A on cisplatin-induced nephrotoxicity in mice via modulation of inflammation and oxidative stress
50. Role of TFEB in autophagic modulation of ischemia reperfusion injury in mice kidney and protection by Urolithin A
51. Safety assessment of Urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid
52. Targeted delivery of microbial metabolite, Urolithin A protects from chemically (DSS or TNBS) induced colitis in pre-clinical models
53. The Activity of Urolithin A and M4 Valerolactone, Colonic Microbiota Metabolites of Polyphenols, in a Prostate Cancer In Vitro Model
54. The Activity of Urolithin A and M4 Valerolactone, Colonic Microbiota Metabolites of Polyphenols, in a Prostate Cancer In Vitro Model
55. The ellagic acid-derived gut microbiota metabolite, Urolithin A, potentiates the anticancer effects of 5-fluorouracil chemotherapy on human colon cancer cells
56. The ellagitannin metabolite urolithin C is a glucose‐dependent regulator of insulin secretion through activation of L‐type calcium channels
57. The gut microbiota ellagic acid-derived metabolite Urolithin A and its sulfate conjugate are substrates for the drug efflux transporter breast cancer resistance protein …
58. The Microbiome Product Urolithin A Abolishes TGFβ-Dependent Stimulation of PAI-1 in Renal Epithelial Cells
59. The Microbiome Product Urolithin A Abrogates the Tgf-β Egfr Pai-1 Pathway by Inhibiting Egfr Activation and Expression
60. The mitophagy activator Urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans
61. Tissue deconjugation of Urolithin A glucuronide to free Urolithin A in systemic inflammation
62. TRANSLATING Urolithin A BENEFITS ON MUSCLE MITOCHONDRIA TO HUMANS
63. Urolithin A (UA) inhibits both androgen receptor and AKT signaling and prevents the progression of castration resistant prostate cancer
64. Urolithin A alleviates myocardial ischemia/reperfusion injury via PI3K/Akt pathway
65. Urolithin A and B Derivatives as ON-OFF Selective Fluorescent Sensors for Iron (III)
66. Urolithin A and Ellagic Acid Inhibit Prostate Cancer Through Different Molecular Mechanisms: Implications of Gut Microbiome Metabolism for Cancer Prevention
67. Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice
68. Urolithin A attenuates ox‐LDL‐induced endothelial dysfunction partly by modulating microRNA‐27 and ERK/PPAR‐γ pathway
69. Urolithin A attenuates oxâ LDLâ induced endothelial dysfunction partly by modulating microRNAâ 27 and ERK/PPARâ γ pathway
70. Urolithin A attenuates pro-inflammatory mediator production by suppressing PI3-K/Akt/NF-κB and JNK/AP-1 signaling pathways in lipopolysaccharide-stimulated …
71. Urolithin A causes p21 up-regulation in prostate cancer cells
72. Urolithin A causes p21 up-regulation in prostate cancer cells
73. Urolithin A gains in antiproliferative capacity by reducing the glycolytic potential via the p53/TIGAR axis in colon cancer cells
74. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents
75. Urolithin A induces prostate cancer cell death in p53-dependent and in p53-independent manner
76. Urolithin A induces prostate cancer cell death in p53-dependent and in p53-independent manner.
77. Urolithin A inhibits the catabolic effect of TNFα on nucleus pulposus cell and alleviates intervertebral disc degeneration in vivo
78. Urolithin A Is a Dietary Microbiota-Derived Human Aryl Hydrocarbon Receptor Antagonist
79. Urolithin A mitigates cisplatin-induced nephrotoxicity by inhibiting renal inflammation and apoptosis in an experimental rat model
80. Urolithin A prevents pancreatic tumor growth and increases survival by inhibiting PI3K/PDK1 and STAT3 signaling
81. Urolithin A shows anti-atherosclerotic activity via activation of class b scavenger receptor and activation of nef2 signaling pathway
82. Urolithin A Suppress Cardiac Fibrosis via Autophagy Pathway in the Diabetic Cardiomyopathy
83. Urolithin A suppresses the proliferation of endometrial cancer cells by mediating estrogen receptor‐α‐dependent gene expression
84. Urolithin A targets the PI3K/Akt/NF-κB pathways and prevents IL-1β-induced inflammatory response in human osteoarthritis: in vitro and in vivo studies
85. Urolithin A‐activated autophagy but not mitophagy protects against ischemic neuronal injury by inhibiting ER stress in vitro and in vivo
86. Urolithin A, a Gut Metabolite, Improves Insulin Sensitivity Through Augmentation of Mitochondrial Function and Biogenesis
87. Urolithin A, a Gut Metabolite, Induces Metabolic Reprogramming of Adipose Tissue by Promoting M2 Macrophage Polarization and Mitochondrial Function (OR12-02 …
88. Urolithin A, a Gut Microbiome Derived Metabolite Improves Mitochondrial and Cellular Health: Results from a Randomized, Placebo-controlled, Double-blind Clinical …
89. Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer
90. Urolithin A, C, and D, but not iso‐Urolithin A and urolithin B, attenuate triglyceride accumulation in human cultures of adipocytes and hepatocytes
91. Urolithin A, Walnut Polyphenol Metabolite, Causes Cell Cycle Arrest and Apoptosis in Prostate and Breast Cancer Cells
92. Urolithin As a converging scaffold linking ellagic acid and coumarin analogues: design of potent protein kinase CK2 inhibitors
93. Urolithin B as a Simple, Selective, Fluorescent Probe for Sensing Iron (III) in Semi-Aqueous Solution
94. Urolithin B, a newly identified regulator of skeletal muscle mass
95. Urolithin C, a gut metabolite of ellagic acid, induces apoptosis in PC12 cells through a mitochondria-mediated pathway
96. V. CHAPTER IV: Urolithin A, C and D, but not iso-Urolithin A and Urolithin B, attenuate triglyceride accumulation in primary cultures of human adipocytes