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(Sirt1 | Sirt 1) (Activator | Activators | Activation)

  1. SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages
  2. Sirt 1 activator inhibits the AGE-induced apoptosis and p53 acetylation in human vascular endothelial cells
  3. Cardiovascular effects of a novel SIRT 1 activator, SRT 2104, in otherwise healthy cigarette smokers
  4. The SIRT1 activator resveratrol protects SKโ€Nโ€BE cells from oxidative stress and against toxicity caused by ฮฑโ€synuclein or amyloidโ€ฮฒ (1โ€42) peptide
  5. Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase
  6. Nobiletin ameliorates hepatic ischemia and reperfusion injury through the activation of SIRT-1/FOXO3a-mediated autophagy and mitochondrial biogenesis
  7. SIRT 1โ€mediated epigenetic downregulation of plasminogen activator inhibitorโ€1 prevents vascular endothelial replicative senescence
  8. PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation
  9. Treadmill exercise decreases amyloid-ฮฒ burden possibly via activation of SIRT-1 signaling in a mouse model of Alzheimerโ€™s disease
  10. Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity
  11. A novel biological role of ฮฑโ€mangostin in modulating inflammatory response through the activation of SIRTโ€1 signaling pathway
  12. Two novel SIRT1 activators, SCIC2 and SCIC2. 1, enhance SIRT1-mediated effects in stress response and senescence
  13. Peroxisome proliferator-activated receptor ฮณ co-activator 1ฮฑ (PGC-1ฮฑ) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrialย โ€ฆ
  14. SIRT1/PGC-1 pathway activation triggers autophagy/mitophagy and attenuates oxidative damage in intestinal epithelial cells
  15. Probing the mechanism of SIRT1 activation by a 1, 4-dihydropyridine
  16. Melatonin attenuates acute kidney ischemia/reperfusion injury in diabetic rats by activation of the SIRT1/Nrf2/HO-1 signaling pathway
  17. Involvement of TACE in colon inflammation: a novel mechanism of regulation via SIRT-1 activation
  18. Nutraceutical activators of AMPK/Sirt1 axis inhibit viral production and protect neurons from neurodegenerative events triggered during HSV-1 infection
  19. Pharmacokinetics and tolerability of SRT 2104, a firstโ€inโ€class small molecule activator of SIRT 1, after single and repeated oral administration in man
  20. Sirtuin 1 (SIRT1) activation mediates sildenafil induced delayed cardioprotection against ischemia-reperfusion injury in mice
  21. PARP-1 inhibition protects the diabetic heart through activation of SIRT1-PGC-1ฮฑ axis
  22. SIRT1 silencing confers neuroprotection through IGFโ€1 pathway activation
  23. Induction of autophagy and activation of SIRTโ€1 deacetylation mechanisms mediate neuroprotection by the pomegranate metabolite urolithin A in BV2 microglia andย โ€ฆ
  24. SirT1 activator represses the transcription of TNFโ€‘ฮฑ in THPโ€‘1 cells of a sepsis model via deacetylation of H4K16
  25. Parthenolide Phytosomes Attenuated Gentamicin-Induced Nephrotoxicity in Rats via Activation of Sirt-1, Nrf2, OH-1, and NQO1 Axis
  26. SIRT 1 activator loaded inhaled antiangiogenic liposomal formulation development for pulmonary hypertension
  27. Oligo-fucoidan improves diabetes-induced renal fibrosis via activation of sirt-1, glp-1r, and nrf2/ho-1: An in vitro and in vivo study
  28. Inhibition of SIRT1 by HIV-1 viral protein Tat results in activation of p53 pathway
  29. ฮฑ-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase
  30. Sirt 1 activator attenuates the bleomycin-induced lung fibrosis in mice via inhibiting epithelial-to-mesenchymal transition (EMT).
  31. Homocysteine facilitates LOX-1 activation and endothelial death through the PKCฮฒ and SIRT1/HSF1 mechanism: relevance to human hyperhomocysteinaemia
  32. โ€ฆย Effect of DiDang Tang Against AlCl3-Induced Oxidative Stress and Apoptosis in PC12 Cells Through the Activation of SIRT1-Mediated Akt/Nrf2/HO-1ย โ€ฆ
  33. AMPK inhibits MTDH expression via GSK 3ฮฒ and SIRT 1 activation: potential role in triple negative breast cancer cell proliferation
  34. Occludin controls HIV transcription in brain pericytes via regulation of SIRT-1 activation
  35. A pharmacological review on SIRT 1 and SIRT 2 proteins, activators, and inhibitors: Call for further research
  36. โ€ฆย dysfunction by cantleyoside confines inflammatory response and promotes apoptosis of human HFLS-RA cell line via AMPK/Sirt 1/NF-ฮบB pathway activation
  37. Low-frequency electroacupuncture improves insulin sensitivity in obese diabetic mice through activation of SIRT1/PGC-1 in skeletal muscle
  38. Activating SIRT-1 Signalling with the Mitochondrial-CoQ10 Activator Solanesol Improves Neurobehavioral and Neurochemical Defects in Ouabain-Inducedย โ€ฆ
  39. Endothelial LOX-1 activation differentially regulates arterial thrombus formation depending on oxLDL levels: role of the Oct-1/SIRT1 and ERK1/2 pathways
  40. Activation of SIRT-1 Signalling in the Prevention of Bipolar Disorder and Related Neurocomplications: Target Activators and Influences on Neurological Dysfunctions
  41. Thymoquinone ameliorates diabetic phenotype in Diet-Induced Obesity mice via activation of SIRT-1-dependent pathways
  42. N1-Methylnicotinamide Improves Hepatic Insulin Sensitivity via Activation of SIRT1 and Inhibition of FOXO1 Acetylation
  43. Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-ฮบB ligand (RANKL) activation of NF-ฮบB signaling and inhibitย โ€ฆ
  44. Resveratrol inhibits the hydrogen dioxide-induced apoptosis via Sirt 1 activation in osteoblast cells
  45. โ€ฆย IIA sulfonate protects against hyperhomocysteine-induced vascular endothelial injury via activation of NNMT/SIRT1-mediated NRF2/HO-1 and AKT/MAPKsย โ€ฆ
  46. โ€ฆย ischemiaโ€“reperfusion injury by reducing oxidative stress and endoplasmic reticulum stress-mediated apoptosis in type 1 diabetic rats: role of SIRT1 activation
  47. Aloin reduces HMGB1-mediated septic responses and improves survival in septic mice by activation of the SIRT1 and PI3K/Nrf2/HO-1 signaling axis
  48. โ€ฆย ethanolic extract attenuates chronic restraint stress aggravated DSS-induced ulcerative colitis in mice via inhibition of NF-ฮบB/STAT3 and activation of HO-1/Nrf2/SIRT1ย โ€ฆ
  49. Activation of AMPK-dependent SIRT-1 by astragalus polysaccharide protects against ochratoxin A-induced immune stress in vitro and in vivo
  50. โ€ฆย confers neuroprotection against hypoxia-ischemia induced brain damage in neonatal rats via autophagy and silent information regulator 1 (SIRT1) activation
  51. Tetrandrine alleviates cerebral ischemia/reperfusion injury by suppressing NLRP3 inflammasome activation via Sirt-1
  52. โ€ฆย M is an anti-aging reagent that eliminates hyperglycemia-accelerated premature senescence in dermal fibroblasts by direct activation of Nrf2 and SIRT-1
  53. 1, 25-Dihydroxyvitamin D decreases tertiary butyl-hydrogen peroxide-induced oxidative stress and increases AMPK/SIRT1 activation in C2C12 muscle cells
  54. Grape seed proanthocyanidins prevent H2O2โ€induced mitochondrial dysfunction and apoptosis via SIRT 1 activation in embryonic kidney cells
  55. Activation of SIRT-1 Pathway by Nanoceria Sheds Light on Its Ameliorative Effect on Doxorubicin-Induced Cognitive Impairment (Chemobrain): Restraining Itsย โ€ฆ
  56. SIRT1 protects against aortic dissection by regulating AP-1/decorin signaling-mediated PDCD4 activation
  57. โ€ฆย the expression of adiponectin in 3T3-L1 adipocytes via the activation of silent mating type information regulation 2 homologue 1 (SIRT1)-deacetylase and peroxisomeย โ€ฆ
  58. Avasimibe and Sirt 1 Activators Reverse NAFLD and Obesity.
  59. โ€ฆย sulfate promotes arterial thrombosis in rat model via increased levels of complex TF/VII, PAI-1, platelet activation as well as decreased contents of SIRT1 andย โ€ฆ
  60. Corylin reduces obesity and insulin resistance and promotes adipose tissue browning through SIRT-1 and ฮฒ3-AR activation
  61. Sirt1 regulates microglial activation and inflammation following oxygen-glucose deprivation/reoxygenation injury by targeting the Shh/Gli-1 signaling pathway
  62. โ€ฆย inhibits hypoxiaโ€inducible factorโ€1 alpha and carbonic anhydrase expression through activation of AMPโ€activated protein kinase/HOโ€1/Sirt1 pathway in glioblastomaย โ€ฆ
  63. Dysregulation of SIRT-1 signaling in multiple sclerosis and neuroimmune disorders: a systematic review of sirtuin activators as potential immunomodulators and theirย โ€ฆ
  64. Discovery of Imidazo[1,2-b]thiazole Derivatives as Novel SIRT1 Activators
  65. A series of novel indazole derivatives of Sirt 1 activator as osteogenic regulators
  66. Fucoidan inhibits apoptosis and improves cardiac remodeling by inhibiting p53 transcriptional activation through USP22/Sirt 1
  67. โ€ฆย Mellitus by Activating Monophosphate-Activated Protein Kinase (AMPK)/Sirtuin 1 (SIRT1) Axis and Inhibiting Nuclear Factor-kappa B (NF-ฮบB) Activation
  68. โ€ฆย acid inhibits insulin-induced activation of sterol regulatory-element binding protein 1 and cyclooxygenase-2 expression through upregulation of SIRT1 in human colonย โ€ฆ
  69. Alpha-lipoic acid attenuates cardiac hypertrophy via downregulation of PARP-2 and subsequent activation of SIRT-1
  70. SIRT-1 ACTIVATORSโ€“IN DIABETIC NEPHROPATHY
  71. Amelioration of high-fat diet (HFD)+ CCl4 induced NASH/NAFLD in CF-1 mice by activation of SIRT-1 using cinnamoyl sulfonamide hydroxamate derivativesย โ€ฆ
  72. Activation of the cannabinoid receptor 1 by ACEA suppresses senescence in human primary chondrocytes through sirt1 activation
  73. HIC2, a new transcription activator of SIRT1
  74. Synthesis of four SIRT1 activators based on an imidazo [1, 2-b] thiazole structure, in vitro derived metabolites and deuterated analogs
  75. Integrated ligand and structure-based investigation of structural requirements for silent information regulator 1 (SIRT1) activation
  76. Solanesol Mediated SIRT-1 Activation Prevents Neurobehavioral and Neurochemical Defects in Ouabain-Induced Experimental Model of Bipolar Disorder in Rats
  77. Solanesol Mediated SIRT-1 Signaling Activation Prevents Neurobehavioral and Neurochemical Defects in Ouabain-induced Experimental Model of Bipolar Disorderย โ€ฆ
  78. Activation of Sirtuin 1 (SIRT1) Signaling by Resveratrol Increases Human Betaโ€Defensinsโ€2 andโ€3 (HBD2, HBD3) Production in Response to Lipopolysaccharideย โ€ฆ
  79. Silent Information Regulator 1 (SIRT1) Promotes Pancreatic ฮฒ-Cell Mitochondrial Autophagy and Pyrin Domains-Containing Protein 3 (NLRP3) Activation Under Highย โ€ฆ
  80. Identification and molecular modeling of novel endogenous activator proteins of Sirt-1: an in silico study.
  81. SIRT-1 ACTIVATOR RESVERATROL PROTECTS HUVECs FROM HIGH GLUCOSE-DEPENDENT REDOX AND GLYCATIVE IMBALANCES
  82. INVESTIGATION OF SIRT-1 ACTIVATOR IN INTRACEREBROPEDUNCLE ETHIDIUM BROMIDE INDUCED EXPERIMENTAL MODEL OF MULTIPLE SCLEROSIS INย โ€ฆ
  83. Cardiovascular Effects of a Novel SIRT 1 Activator, SRT2104, in Otherwise Healthy Cigarette Smokers
  84. Cardiovascular effects of the treatments for diabetes mellitus: the effect of SIRT-1 activation on markers of endothelial function, arterial stiffness and thrombosis; andย โ€ฆ
  85. โ€ฆย OF NOVEL 4-THIAZOLIDINONE DERIVATIVES BEARING 1, 3, 4-OXADIAZOLE MOIETY AS SIRT-3 ACTIVATORS TARGETING PARKINSONโ€™S DISEASE
  86. SirT1 blocks apoptosis in human chondrocytes via activation of the IGF-1 Receptor/Akt pathway
  87. GW25-e1524 SIRT1-Mediated Epigenetic Downregulation of Plasminogen Activator Inhibitor-1 Prevents Vascular Endothelial Replicative Senescence
  88. Ligand docking suggests isomer specific catechin induced SIRTโ€1 activation
  89. โ€ฆย modeling, Molecular Dynamic Simulation and in silico screening of Activator for the Intensification of human sirtuin type 1 (SIRT1) by novel 1, 3, 4-thiadiazoleย โ€ฆ
  90. Treadmill exercise upregulates the non-amyloidogenic pathway and inhibits amyloid-b production via activation of SIRT-1 signaling in a mouse model of Alzheimerโ€™sย โ€ฆ
  91. Activation of a class-III histone deacetylase, SIRT1, prevents the oxidative-stress mediated cell-death by suppressing the activity of poly (ADP) ribose polymerase-1
  92. Sirt-1 Induces Vascular Endothelial Growth Factor Through The Activation of HIF-2ฮฑ In Hypoxia
  93. Endothelial LOX-1 Protects Against Arterial Thrombosis via Activation of the Oct-1/SIRT1 Pathway
  94. Hsp90 inhibition suppresses NF-kB transcriptional activation via Sirt-2 in human 1 lung microvascular endothelial cells. 2
  95. Activation of the AKT Pathway Mediates Upregulation of Hif-1ฮฑ and Sirt1 via Downregulation of miR-199a and is Neutralized by Beta-adrenergic Stimulation
  96. Paeonol attenuates high glucose-induced expression of FN and ICAM-1 by promoting the activation of Nrf2/ARE pathway via upregulation of Sirt1 in GMCs
  97. Synthesis and Yeast-based Screening of 1, 3-benzodioxole Derivatives for SIRT1 Activators
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