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Phosphatidylinositol 3 Kinase

  1. Phosphatidylinositol 3โ€kinase
  2. Activation of Phosphatidylinositol 3โ€“kinase by insulin.
  3. The activation of Phosphatidylinositol 3โ€“kinase by Ras
  4. Association of focal adhesion kinase with its potential substrate Phosphatidylinositol 3โ€“kinase.
  5. Phosphatidylinositol 3โ€“kinase related kinases
  6. Phosphatidylinositol 3โ€“kinase Encoded by Yeast VPS34 Gene Essential for Protein Sorting
  7. Phosphatidylinositol 3โ€“kinase: structure and expression of the 110 kd catalytic subunit
  8. Wortmannin is a potent Phosphatidylinositol 3โ€“kinase inhibitor: the role of Phosphatidylinositol 3, 4, 5-trisphosphate in neutrophil responses
  9. Requirement for Phosphatidylinositolโ€“3 kinase in the prevention of apoptosis by nerve growth factor
  10. Ras-dependent induction of cellular responses by constitutively active Phosphatidylinositolโ€“3 kinase
  11. Activation of Phosphatidylinositolโ€“3โ€ฒ kinase by Src-family kinase SH3 binding to the p85 subunit
  12. Phosphatidylinositol 3โ€ฒโ€kinase is activated by association with IRSโ€1 during insulin stimulation.
  13. A human Phosphatidylinositol 3โ€kinase complex related to the yeast Vps34pโ€Vps15p protein sorting system.
  14. Wortmannin, a potent and selective inhibitor of Phosphatidylinositolโ€“3โ€“kinase
  15. A specific inhibitor of Phosphatidylinositol 3โ€“kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).
  16. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated Phosphatidylinositol 3โ€“kinase
  17. Membrane localization of Phosphatidylinositol 3โ€“kinase is sufficient to activate multiple signal-transducing kinase pathways
  18. The Phosphatidylinositol 3โ€“kinase alpha is required for DNA synthesis induced by some, but not all, growth factors.
  19. Cloning of a novel, ubiquitously expressed human Phosphatidylinositol 3โ€“kinase and identification of its binding site on p85
  20. Inhibition of Phosphatidylinositol 3โ€“kinase activity by association with 14-3โ€“3 proteins in T cells.
  21. Phosphatidylinositol 3โ€˜kinase: one of the effectors of Ras
  22. Association of p21ras with Phosphatidylinositol 3โ€“kinase.
  23. Interaction of Phosphatidylinositol 3โ€“kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors
  24. ErbB3 is involved in activation of Phosphatidylinositol 3โ€“kinase by epidermal growth factor
  25. Phosphatidylinositolโ€“3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells
  26. Activation of the Eck receptor protein tyrosine kinase stimulates Phosphatidylinositol 3โ€“kinase activity.
  27. Phosphatidylinositol 3โ€“kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation
  28. The inhibition of Phosphatidylinositol 3โ€“kinase by quercetin and analogs
  29. Phosphatidylinositol 3โ€“kinase inhibitors block differentiation of skeletal muscle cells
  30. Studies on the mechanism of Phosphatidylinositol 3โ€“kinase inhibition by wortmannin and related analogs
  31. CD19 of B cells as a surrogate kinase insert region to bind Phosphatidylinositol 3โ€“kinase
  32. DNA-dependent protein kinase catalytic subunit: a relative of Phosphatidylinositol 3โ€“kinase and the ataxia telangiectasia gene product
  33. Involvement of Phosphatidylinositol 3โ€“kinase in Fc gamma receptor signaling.
  34. The interaction of small domains between the subunits of Phosphatidylinositol 3โ€“kinase determines enzyme activity
  35. Interkinase domain of kit contains the binding site for Phosphatidylinositol 3โ€˜kinase.
  36. Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, Phosphatidylinositol 3โ€˜-kinase, and protein kinase C.
  37. Mouse p170 is a novel Phosphatidylinositol 3โ€“kinase containing a C2 domain
  38. Inhibition of the Phosphatidylinositol 3โ€“kinase/p70S6-kinase pathway induces B16 melanoma cell differentiation
  39. Epidermal growth factor-dependent association of Phosphatidylinositol 3โ€“kinase with the erbB3 gene product.
  40. The structure and function of p55PIK reveal a new regulatory subunit for Phosphatidylinositol 3โ€“kinase
  41. Phosphatidylinositol 3โ€“kinase and its novel product, Phosphatidylinositol 3-phosphate, are present in Saccharomyces cerevisiae
  42. Phosphatidylinositol 3โ€“kinase Is an Early Intermediate in the Gฮฒฮณ-mediated Mitogen-activated Protein kinase Signaling Pathway (โˆ—)
  43. Phosphatidylinositol (3, 4, 5) P3 interacts with SH2 domains and modulates PI 3โ€“kinase association with tyrosine-phosphorylated proteins
  44. Rac GTPase interacts specifically with Phosphatidylinositol 3โ€“kinase
  45. The Phosphatidylinositol 3โ€“kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin.
  46. Insulin stimulation of Phosphatidylinositol 3โ€“kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat.
  47. A novel recognition motif for Phosphatidylinositol 3โ€“kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor
  48. In vitro and in vivo antitumor activity of the Phosphatidylinositolโ€“3โ€“kinase inhibitor, wortmannin.
  49. Essential role of Phosphatidylinositol 3โ€“kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor โ€ฆ
  50. Activation of Phosphatidylinositol 3โ€“kinase in cells expressing abl oncogene variants
  51. Regulation of Phosphatidylinositol 3โ€“kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus.
  52. EGF or PDGF receptors activate atypical PKClambda through Phosphatidylinositol 3โ€kinase.
  53. T-cell antigen CD28 interacts with the lipid kinase Phosphatidylinositol 3โ€“kinase by a cytoplasmic Tyr (P)-Met-Xaa-Met motif.
  54. Investigation of neutrophil signal transduction using a specific inhibitor of Phosphatidylinositol 3โ€“kinase.
  55. Evidence for Phosphatidylinositol 3โ€“kinase as a regulator of endocytosis via activation of Rab5.
  56. The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with Phosphatidylinositol 3โ€“kinase.
  57. Insulin activates a p21-activated kinase in muscle cells via Phosphatidylinositol 3โ€“kinase
  58. Phosphatidylinositol 3โ€“kinase signals activate a selective subset of Rac/Rho-dependent effector pathways
  59. Inhibition of histamine secretion by wortmannin through the blockade of Phosphatidylinositol 3โ€“kinase in RBL-2H3 cells.
  60. Phosphatidylinositol 3โ€“kinase binds to ฮฑ-actinin through the p85 subunit
  61. Phospholipase C-ฮณ1 and Phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptorโ€™s mitogenic signal
  62. Identification of cโ€erbBโ€3 binding sites for Phosphatidylinositol 3โ€ฒโ€kinase and SHC using an EGF receptor/cโ€erbBโ€3 chimera.
  63. Akt Is a Direct Target of the Phosphatidylinositol 3โ€“kinase: ACTIVATION BY GROWTH FACTORS, v-src and v-Ha-ras, IN Sf9 AND MAMMALIAN CELLS
  64. SH2 domains of the p85 alpha subunit of Phosphatidylinositol 3โ€“kinase regulate binding to growth factor receptors
  65. Role for Phosphatidylinositol 3โ€“kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells.
  66. Oligodendrocytes and their precursors require Phosphatidylinositol 3โ€“kinase signaling for survival
  67. Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the Phosphatidylinositol 3โ€“kinase inhibitor, wortmannin
  68. Identification of Trk binding sites for SHC and Phosphatidylinositol 3โ€˜-kinase and formation of a multimeric signaling complex.
  69. Phosphatidylinositol 3โ€“kinase activity is required for early endosome fusion
  70. CTLA-4 binding to the lipid kinase Phosphatidylinositol 3โ€“kinase in T cells.
  71. Wortmannin, a specific inhibitor of Phosphatidylinositolโ€“3 kinase, blocks osteoclastic bone resorption
  72. Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of Phosphatidylinositol 3โ€“kinase.
  73. Dominant missense mutations in a novel yeast protein related to mammalian Phosphatidylinositol 3โ€“kinase and VPS34 abrogate rapamycin cytotoxicity
  74. Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for Phosphatidylinositol 3โ€˜kinase.
  75. Molecular cloning, cDNA sequence, and chromosomal localization of the human Phosphatidylinositol 3โ€“kinase p110ฮฑ (PIK3CA) gene
  76. Phosphatidylinositol 3โ€“kinase Activity Is Required at a Postendocytic Step in Platelet-derived Growth Factor Receptor Traffickingโˆ—
  77. Requirement of Phosphatidylinositolโ€“3 kinase modification for its association with p60src
  78. Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of Phosphatidylinositol 3โ€“kinase.
  79. Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for Phosphatidylinositol 3 kinase.
  80. CD28 of T lymphocytes associates with Phosphatidylinositol 3โ€“kinase
  81. The v-Src SH3 domain binds Phosphatidylinositol 3โ€˜-kinase
  82. Signal transduction via CD40 involves activation of lyn kinase and Phosphatidylinositolโ€“3โ€“kinase, and phosphorylation of phospholipase C gamma 2.
  83. Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of Phosphatidylinositol 3โ€“kinase.
  84. Hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells requires Phosphatidylinositol 3โ€“kinase
  85. Role of Phosphatidylinositolโ€“3โ€“kinase in insulin receptor signaling: studies with inhibitor, LY294002
  86. Identification of two SH3-binding motifs in the regulatory subunit of Phosphatidylinositol 3โ€“kinase.
  87. Acute regulation by insulin of Phosphatidylinositolโ€“3โ€“kinase, Rad, Glut 4, and lipoprotein lipase mRNA levels in human muscle.
  88. Phosphatidylinositol 3โ€kinase regulation of fluid phase endocytosis
  89. Phosphatidylinositol 3โ€“kinase activation in normal human B lymphocytes.
  90. Wortmannin, a specific Phosphatidylinositol 3โ€“kinase inhibitor, inhibits adipocytic differentiation of 3T3-L1 cells
  91. A Phosphatidylinositolโ€“3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine
  92. Solution structure and ligand-binding site of the SH3 domain of the p85ฮฑ subunit of Phosphatidylinositol 3โ€“kinase
  93. Polyphosphoinositides produced by Phosphatidylinositol 3โ€“kinase are poor substrates for phospholipases C from rat liver and bovine brain
  94. Stimulation of CD28 triggers an association between CD28 and Phosphatidylinositol 3โ€“kinase in Jurkat T cells.
  95. A comparison of demethoxyviridin and wortmannin as inhibitors of Phosphatidylinositol 3โ€kinase
  96. Activated Phosphatidylinositol 3โ€“kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes
  97. Interactions of Cbl with Grb2 and Phosphatidylinositol 3โ€˜-kinase in activated Jurkat cells
  98. Membrane Ig cross-linking regulates Phosphatidylinositol 3โ€“kinase in B lymphocytes.
  99. Growth factor-dependent survival of rodent fibroblasts requires Phosphatidylinositol 3โ€“kinase but is independent of pp70S6K activity.
  100. Selective CD28pYMNM mutations implicate Phosphatidylinositol 3โ€“kinase in CD86-CD28-mediated costimulation
  101. Direct activation of the Phosphatidylinositol 3โ€˜-kinase by the insulin receptor.
  102. Nerve growth factor promotes the activation of Phosphatidylinositol 3โ€“kinase and its association with the trk tyrosine kinase.
  103. โ€ฆ factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or Phosphatidylinositol 3โ€“kinase.
  104. Phosphorylation of middle T by pp60c-src: a switch for binding of Phosphatidylinositol 3โ€“kinase and optimal tumorigenesis
  105. Activation of Src-like protein-tyrosine kinase Lyn and its association with Phosphatidylinositol 3โ€“kinase upon B-cell antigen receptor-mediated signaling.
  106. Direct Association of Grb2 with the p85 Subunit of Phosphatidylinositol 3โ€“kinase (โˆ—)
  107. Overexpression of a constitutively active form of Phosphatidylinositol 3โ€“kinase is sufficient to promote Glut 4 translocation in adipocytes
  108. Antagonists of Phosphatidylinositol 3โ€“kinase block activation of several novel protein kinases in neutrophils
  109. Interleukin-2 triggers a novel Phosphatidylinositol 3โ€“kinase-dependent MEK activation pathway
  110. GTPase-activating protein and Phosphatidylinositol 3โ€“kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit
  111. Defect in skeletal muscle Phosphatidylinositolโ€“3โ€“kinase in obese insulin-resistant mice.
  112. Protein kinase C ฮด specifically associates with Phosphatidylinositol 3โ€“kinase following cytokine stimulation
  113. p56Lck and p59Fyn regulate CD28 binding to Phosphatidylinositol 3โ€“kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase โ€ฆ
  114. Phosphatidylinositol 3โ€“kinase activation is mediated by high-affinity interactions between distinct domains within the p110 and p85 subunits
  115. AtVPS34, a Phosphatidylinositol 3โ€“kinase of Arabidopsis thaliana, is an essential protein with homology to a calcium-dependent lipid binding domain.
  116. Efficient coupling with Phosphatidylinositol 3โ€“kinase, but not phospholipase C gamma or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other โ€ฆ
  117. Requirement for Phosphatidylinositol 3โ€“kinase in epidermal growth factor-induced AP-1 transactivation and transformation in JB6 P+ cells
  118. Modulation of insulin receptor, insulin receptor substrate-1, and Phosphatidylinositol 3โ€“kinase in liver and muscle of dexamethasone-treated rats.
  119. Adrenergic Receptors Activate Phosphatidylinositol 3โ€“kinase in Human Vascular Smooth Muscle Cells: ROLE IN MITOGENESIS (โˆ—)
  120. Phosphatidylinositolโ€“3 kinase activation induced upon Fc gamma RIIIA-ligand interaction.
  121. Phosphatidylinositol 3โ€“kinase is activated by nerve growth factor and epidermal growth factor in PC12 cells.
  122. Insulin-stimulated Phosphatidylinositol 3โ€“kinase. Association with a 185-kDa tyrosine-phosphorylated protein (IRS-1) and localization in a low density โ€ฆ
  123. Regulation of Phosphatidylinositol 3โ€ฒ-kinase by tyrosyl phosphoproteins: full activation requires occupancy of Both SH2 domains in the 85-kDa regulatory โ€ฆ
  124. Wortmannin causes mistargeting of procathepsin D. evidence for the involvement of a Phosphatidylinositol 3โ€“kinase in vesicular transport to lysosomes.
  125. Phosphatidylinositol 3โ€“kinase associates, via its Src homology 2 domains, with the activated erythropoietin receptor
  126. Phosphatidylinositol 3โ€“kinase mediates the inhibitory effect of epidermal growth factor on calcium-dependent chloride secretion
  127. The Phosphatidylinositol 3โ€“kinase Inhibitor Wortmannin Sensitizes Murine Fibroblasts and Human Tumor Cells to Radiation and Blocks Induction of p53 following โ€ฆ
  128. 1-Phosphatidylinositol 3โ€“kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells.
  129. The inability of Phosphatidylinositol 3โ€“kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated โ€ฆ
  130. Insulin stimulation of Phosphatidylinositol 3โ€“kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation.
  131. Overexpression of catalytic subunit p110ฮฑ of Phosphatidylinositol 3โ€“kinase increases glucose transport activity with translocation of glucose transporters in โ€ฆ
  132. Platelet-derived growth factor-induced Phosphatidylinositol 3โ€“kinase activation mediates actin rearrangements in fibroblasts
  133. Regulated coupling of the Neu receptor to Phosphatidylinositol 3โ€˜-kinase and its release by oncogenic activation.
  134. Requirement for Phosphatidylinositol 3โ€˜-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor.
  135. The proto-oncogene product p120CBL and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR/ABL and p210BCR/ABL to the Phosphatidylinositolโ€“3โ€˜kinase โ€ฆ
  136. Internalization of activated platelet-derived growth factor receptor-Phosphatidylinositolโ€“3โ€˜kinase complexes: potential interactions with the microtubule cytoskeleton
  137. A regulatory role for cAMP in Phosphatidylinositol 3โ€“kinase/p70 ribosomal S6 kinase-mediated DNA synthesis in platelet-derived-growth-factor-stimulated bovine โ€ฆ
  138. Phosphatidylinositol 3โ€“kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation.
  139. Bacterial lipopolysaccharide induces the association and coordinate activation of p53/56lyn and Phosphatidylinositol 3โ€“kinase in human monocytes.
  140. Two types of Phosphatidylinositol 3โ€“kinase from bovine thymus. Monomer and heterodimer form
  141. Multiple roles of Phosphatidylinositol 3โ€“kinase in regulation of glucose transport, amino acid transport, and glucose transporters in L6 skeletal muscle cells
  142. Stimulation of Phosphatidylinositol 3โ€˜-kinase association with foca adhesion kinase by platelet-derived growth factor.
  143. Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and Phosphatidylinositol 3โ€“kinase activity are decreased in intact skeletal muscle strips โ€ฆ
  144. Association of Phosphatidylinositol 3โ€“kinase with SHC in chronic myelogeneous leukemia cells.
  145. Both Phosphatidylinositol 3โ€“kinase and Phosphatidylinositol 4-kinase products are increased by antigen receptor signaling in B cells.
  146. Profilin and gelsolin stimulate Phosphatidylinositol 3โ€“kinase activity
  147. Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding Phosphatidylinositol 3โ€“kinase
  148. โ€ฆ Inhibit Stimulated Phospholipase A2 Activity in Swiss 3T3 Cells: WORTMANNIN IS NOT A SPECIFIC INHIBITOR OF Phosphatidylinositol 3โ€“kinase (โˆ— โ€ฆ
  149. Insulin and insulinomimetic agents induce activation of Phosphatidylinositol 3โ€˜-kinase upon its association with pp185 (IRS-1) in intact rat livers.
  150. Multiple cytokines activate Phosphatidylinositol 3โ€“kinase in hemopoietic cells. Association of the enzyme with various tyrosine-phosphorylated proteins.
  151. IRS-1 activates Phosphatidylinositol 3โ€˜-kinase by associating with src homology 2 domains of p85.
  152. Requirement of Phosphatidylinositolโ€“3 kinase for epithelial cell migration activated by human macrophage stimulating protein.
  153. Effect of aging on insulin receptor, insulin receptor substrate-1, and Phosphatidylinositol 3โ€“kinase in liver and muscle of rats
  154. Biased combinatorial libraries: novel ligands for the SH3 domain of Phosphatidylinositol 3โ€“kinase
  155. IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the Phosphatidylinositol 3โ€˜-kinase
  156. Phosphatidylinositol 3โ€“kinase Recruitment by p185erbB-2 and erbB-3 Is Potently Induced by neu Differentiation Factor/Heregulin during Mitogenesis and Is โ€ฆ
  157. Genetic analysis of a Phosphatidylinositol 3โ€“kinase SH2 domain reveals determinants of specificity
  158. Interleukin-10 stimulation of Phosphatidylinositol 3โ€“kinase and p70 S6 kinase is required for the proliferative but not the antiinflammatory effects of the cytokine
  159. Heregulin Stimulates Mitogenesis and Phosphatidylinositol 3โ€“kinase in Mouse Fibroblasts Transfected with erbB2/neu and erbB3 (โˆ—)
  160. Phosphatidylinositolโ€“3โ€“kinase in isolated rat adipocytes. Activation by insulin and subcellular distribution.
  161. A Phosphatidylinositol 3โ€“kinase is induced during soybean nodule organogenesis and is associated with membrane proliferation.
  162. A role for Phosphatidylinositol 3โ€“kinase in the regulation of beta 1 integrin activity by the CD2 antigen.
  163. Association of Phosphatidylinositol 3โ€“kinase with a specific sequence of the T cell receptor zeta chain is dependent on T cell activation.
  164. Interferon-ฮฑ Engages the Insulin Receptor Substrate-1 to Associate with the Phosphatidylinositol 3โ€ฒ-kinase (โˆ—)
  165. Platelet-derived growth factor-dependent activation of Phosphatidylinositol 3โ€“kinase is regulated by receptor binding of SH2-domain-containing proteins which โ€ฆ
  166. Activation of Mitogen-activated Protein kinase and Phosphatidylinositol 3โ€ฒ-kinase Is Not Sufficient for the Hormonal Stimulation of Glucose Uptake โ€ฆ
  167. โ€ฆ through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/Phosphatidylinositol 3โ€“kinase complex in human B cell โ€ฆ
  168. Novel functions of Phosphatidylinositol 3โ€“kinase in terminally differentiated cells
  169. Phosphatidylinositol 3โ€“kinase p85 SH2 domain specificity defined by direct phosphopeptide/SH2 domain binding
  170. Activation of the zeta isozyme of protein kinase C by Phosphatidylinositol 3, 4, 5-trisphosphate.
  171. โ€ฆ Mitogen-activated Protein kinase Activation by Platelet-activating Factor through a Mechanism Independent of p85/p110-type Phosphatidylinositol 3โ€“kinase โ€ฆ
  172. Phosphatidylinositol 3โ€“kinase and p70 s6 kinase participate in the regulation of protein turnover in skeletal muscle by insulin and insulin-like growth factor I
  173. Specific association of the ฮฒ isoform of the p85 subunit of Phosphatidylinositolโ€“3 kinase with the proto-oncogene c-cbl
  174. Insulin-mediated Targeting of Phosphatidylinositol 3โ€“kinase to GLUT4-containing Vesicles (โˆ—)
  175. HGF-mediated chemotaxis and tubulogenesis require activation of the Phosphatidylinositol 3โ€“kinase
  176. CD28-mediated costimulation in the absence of Phosphatidylinositol 3โ€“kinase association and activation
  177. Phosphatidylinositol 3โ€“kinase functions upstream of Ras and Raf in mediating insulin stimulation of c-fos transcription
  178. Expression and characterization of the p85 subunit of the Phosphatidylinositol 3โ€“kinase complex and a related p85ฮฒ protein by using the baculovirus expression โ€ฆ
  179. Involvement of Phosphatidylinositol 3โ€“kinase in the activation of extracellular signal-regulated kinase by PDGF in hepatic stellate cells
  180. Two Distinct Intracytoplasmic Regions of the T-cell Adhesion Molecule CD28 Participate in Phosphatidylinositol 3โ€“kinase Association (โˆ—)
  181. Receptor tyrosine kinase stimulates cell-matrix adhesion by Phosphatidylinositol 3 kinase and phospholipase C-gamma 1 pathways
  182. CD28 delivers costimulatory signals independently of its association with Phosphatidylinositol 3โ€“kinase.
  183. Thrombin-dependent association of Phosphatidylinositolโ€“3 kinase with p60c-src and p59fyn in human platelets
  184. Polyoma virus middle T antigen-pp60c-src complex associates with purified Phosphatidylinositol 3โ€“kinase in vitro.
  185. ARIA/HRG regulates AChR epsilon subunit gene expression at the neuromuscular synapse via activation of Phosphatidylinositol 3โ€“kinase and Ras/MAPK pathway.
  186. Brush Border Phosphatidylinositol 3โ€“kinase Mediates Epidermal Growth Factor Stimulation of Intestinal NaCl Absorption and Na+/H+ Exchange (โˆ—)
  187. Interaction of the Flt-1 Tyrosine kinase Receptor with the p85 Subunit of Phosphatidylinositol 3โ€“kinase: MAPPING OF A NOVEL SITE INVOLVED IN BINDING โ€ฆ
  188. Activation of Phosphatidylinositolโ€“3 kinase by ligation of the interleukin-7 receptor is dependent on protein tyrosine kinase activity
  189. โ€ฆ receptor activation of Phosphatidylinositol 3โ€“kinase. von Willebrand factor stimulates the cytoskeletal association and activation of Phosphatidylinositol 3โ€“kinase and โ€ฆ
  190. Fc receptor stimulation of Phosphatidylinositol 3โ€“kinase in natural killer cells is associated with protein kinase C-independent granule release and cell-mediated โ€ฆ
  191. The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of Phosphatidylinositol 3โ€“kinase to phosphorylated platelet-derived โ€ฆ
  192. Interleukinโ€7 induces the association of Phosphatidylinositol 3โ€kinase with the ฮฑ chain of the interleukinโ€7 receptor
  193. A biosensor approach to probe the structure and function of the p85 alpha subunit of the Phosphatidylinositol 3โ€“kinase complex
  194. ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and Phosphatidylinositol 3โ€“kinase activation in cultured โ€ฆ
  195. Activation of Phosphatidylinositol 3โ€“kinase by epidermal growth factor, basic fibroblast growth factor, and nerve growth factor in PC12 pheochromocytoma cells.
  196. Insulin Stimulates Phosphatidylinositolโ€3โ€kinase activity in rat adipocytes
  197. Wortmannin binds specifically to 1-Phosphatidylinositol 3โ€“kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil โ€ฆ
  198. Erythropoietin-dependent association of Phosphatidylinositol 3โ€“kinase with tyrosine-phosphorylated erythropoietin receptor.
  199. The colony stimulating factor-1 receptor associates with and activates Phosphatidylinositolโ€“3 kinase
  200. Phosphatidylinositolโ€“3 kinase and growth regulation
  201. Divergent regulation of Phosphatidylinositol 3โ€“kinase P85 alpha and P85 beta isoforms upon T cell activation
  202. Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of Phosphatidylinositol 3โ€“kinase in muscle and brain
  203. Tumor Necrosis Factor Promotes Phosphorylation and Binding of Insulin Receptor Substrate 1 to Phosphatidylinositol 3โ€“kinase in 3T3-L1 Adipocytes (โˆ—)
  204. A region of the 85-kilodalton (kDa) subunit of Phosphatidylinositol 3โ€“kinase binds the 110-kDa catalytic subunit in vivo
  205. Phosphatidylinositol 3โ€“kinase acts at an intracellular membrane site to enhance GLUT4 exocytosis in 3T3-L1 cells
  206. Functional association of CD7 with Phosphatidylinositol 3โ€“kinase: interaction via a YEDM motif
  207. Roles of 1-Phosphatidylinositol 3โ€“kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cells
  208. โ€ฆ within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated Phosphatidylinositolโ€“3 kinase activity without affecting โ€ฆ
  209. Nuclear translocation of Phosphatidylinositol 3โ€“kinase in rat pheochromocytoma PC 12 cells after treatment with nerve growth factor.
  210. Association of phosphorylated insulin-like growth factor-I receptor with the SH2 domains of Phosphatidylinositol 3โ€“kinase p85.
  211. Phosphatidylinositol 3โ€“kinase activity is required for hepatocyte growth factor-induced mitogenic signals in epithelial cells
  212. The insulin and insulin-like growth factor-I receptor substrate IRS-1 associates with and activates Phosphatidylinositol 3โ€“kinase in vitro.
  213. An inhibitory role for Phosphatidylinositol 3โ€“kinase in insulin secretion from pancreatic B cell line MIN6
  214. Rapid turnover of Phosphatidylinositol 3-phosphate in the green alga Chlamydomonas eugametos: signs of a phosphatidylinositide 3โ€“kinase signalling pathway in โ€ฆ
  215. Ionizing Radiation Stimulates a Grb2-mediated Association of the Stress-activated Protein kinase with Phosphatidylinositol 3โ€“kinase (โˆ—)
  216. Essential role of Phosphatidylinositol 3โ€kinase in insulinโ€induced activation and phosphorylation of the cGMPโ€inhibited cAMP phosphodiesterase in rat adipocytes โ€ฆ
  217. Inhibition of Phosphatidylinositol 3โ€kinase blocks T cell antigen receptor/CD3โ€induced activation of the mitogenโ€activated kinase Erk2
  218. Insulin receptor substrate-1 mediates Phosphatidylinositol 3โ€˜-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation.
  219. Purification and characterization of a Phosphatidylinositol 3โ€“kinase complex from bovine brain by using phosphopeptide affinity columns
  220. Association of the p85 regulatory subunit of Phosphatidylinositol 3โ€“kinase with an essential erythropoietin receptor subdomain
  221. The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with Phosphatidylinositol 3โ€˜-kinase
  222. A Novel 55-kDa Regulatory Subunit for Phosphatidylinositol 3โ€“kinase Structurally Similar to p55PIK Is Generated by Alternative Splicing of the p85ฮฑ Gene (โˆ—)
  223. The Phosphatidylinositol 3โ€“kinase inhibitor wortmannin blocks mast cell exocytosis but not IL-6 production.
  224. In vivo binding properties of SH2 domains from GTPase-activating protein and Phosphatidylinositol 3โ€“kinase
  225. โ€ฆ . Rapid induction of tyrosine phosphorylation, activation of syk tyrosine kinase, and phosphorylation of phospholipase C-gamma and Phosphatidylinositol 3โ€“kinase.
  226. Wortmannin, a potent inhibitor of Phosphatidylinositol 3โ€“kinase, inhibits osteoclastic bone resorption in vitro
  227. Structure and function of Phosphatidylinositol 3โ€“kinase: a potential second messenger system involved in growth control
  228. Role of Phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in haemopoietic cells: Phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in โ€ฆ
  229. Biochemical and pharmacological studies with KT7692 and LY294002 on the role of Phosphatidylinositol 3โ€“kinase in FcฮตRI-mediated signal transduction
  230. The SH3 domain of p56lck is involved in binding to Phosphatidylinositol 3โ€˜-kinase from T lymphocytes
  231. Activation of Phosphatidylinositol 3โ€“kinase by prolactin in Nb2 cells
  232. Selective inhibition of p70 S6 kinase activation by Phosphatidylinositol 3โ€kinase inhibitors
  233. Expression of Dominant Negative Mutant SHPTP2 Attenuates Phosphatidylinositol 3โ€ฒ-kinase Activity via Modulation of Phosphorylation of Insulin Receptor โ€ฆ
  234. Src-homology 3 domain of protein kinase p59fyn mediates binding to Phosphatidylinositol 3โ€“kinase in T cells.
  235. Effect of the Activation of Phosphatidylinositol 3โ€“kinase by a Thiophosphotyrosine Peptide on Glucose Transport in 3T3-L1 Adipocytes (โˆ—)
  236. A mutational analysis of Phosphatidylinositolโ€“3โ€“kinase activation by human colony-stimulating factor-1 receptor
  237. Phosphatidylinositolโ€“3 kinase is activated in v-src, v-yes, and v-fps transformed chicken embryo fibroblasts.
  238. Insulin-mediated inhibition of apolipoprotein B secretion requires an intracellular trafficking event and Phosphatidylinositol 3โ€“kinase activation: studies with brefeldin A โ€ฆ
  239. Phosphatidylinositol 3โ€“kinase, but Not p70/p85 Ribosomal S6 Protein kinase, Is Required for the Regulation of Phosphoenolpyruvate Carboxykinase โ€ฆ
  240. Activation of Phosphatidylinositolโ€3โ€kinase in Jurkat T cells depends on the presence of the p56lck tyrosine kinase
  241. Embryonic mesoderm cells spread in response to platelet-derived growth factor and signaling by Phosphatidylinositol 3โ€“kinase.
  242. Inhibition of the signalling enzyme Phosphatidylinositolโ€“3โ€“kinase by antitumor ether lipid analogues
  243. Formation of c-Cblยท Phosphatidylinositol 3โ€“kinase Complexes on Lymphocyte Membranes by a p56lck-independent Mechanism
  244. Activation of protein kinase C by Phosphatidylinositol 3, 4, 5-trisphosphate
  245. Activation of Phosphatidylinositolโ€“3 kinase by ligation of the interleukin-7 receptor on human thymocytes.
  246. T Cell Activation-dependent Association between the p85 Subunit of the Phosphatidylinositol 3โ€“kinase and Grb2/Phospholipase C-ฮณ1-binding Phosphotyrosyl โ€ฆ
  247. Phosphatidylinositol 3โ€“kinase-independent signal transduction pathway for platelet-derived growth factor-induced chemotaxis
  248. Microinjection of the SH2 domain of the 85-kilodalton subunit of Phosphatidylinositol 3โ€“kinase inhibits insulin-induced DNA synthesis and c-fos expression
  249. Phosphatidylinositol 3โ€“kinase activity is important for progesterone-induced Xenopus oocyte maturation
  250. Phosphatidylinositol 3โ€“kinase is necessary and sufficient for insulin-stimulated stress fiber breakdown
  251. Interleukin-2 receptor regulates activation of Phosphatidylinositol 3โ€“kinase
  252. โ€ฆ interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and Phosphatidylinositol 3โ€“kinase
  253. The Src-family kinase, Fyn, regulates the activation of Phosphatidylinositol 3โ€“kinase in an interleukin 2-responsive T cell line.
  254. Insulin like growth factor-I induces limited association of Phosphatidylinositol 3โ€“kinase to its receptor.
  255. Requirement for Phosphatidylinositol 3โ€ฒ-kinase Activity in Platelet-derived Growth Factor-stimulated Tyrosine Phosphorylation of p125 Focal Adhesion โ€ฆ
  256. PDGF-mediated activation of Phosphatidylinositol 3 kinase in human mesangial cells
  257. Direct association of p110 beta Phosphatidylinositol 3โ€“kinase with p85 is mediated by an N-terminal fragment of p110 beta
  258. JAK3 protein tyrosine kinase mediates interleukin-7-induced activation of Phosphatidylinositolโ€“3โ€˜kinase
  259. Activation of Phosphatidylinositolโ€“3 kinase by nerve growth factor involves indirect coupling of the trk proto-oncogene with src homology 2 domains
  260. โ€ฆ Receptor Stimulation and Interacts in Vivo with Fyn and Syk Tyrosine kinases, Grb2 and Shc Adaptors, and the p85 Subunit of Phosphatidylinositol 3โ€“kinase โ€ฆ
  261. Signal transduction in neutrophil activation Phosphatidylinositol 3โ€kinase is stimulated without tyrosine phosphorylation
  262. Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of Phosphatidylinositol 3โ€“kinase
  263. Different Effects of Insulin and Plateletโ€Derived Growth Factor on Phosphatidylinositol 3โ€kinase at the Subcellular Level in 3T3โ€L1 Adipocytes: A Possible Explanation โ€ฆ
  264. โ€ฆ translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and Phosphatidylinositol 3โ€“kinase
  265. A multiwell assay for inhibitors of Phosphatidylinositolโ€“3โ€“kinase and the identification of natural product inhibitors.
  266. Physiologic Levels of ฮฒโ€Amyloid Activate Phosphatidylinositol 3โ€kinase with the Involvement of Tyrosine Phosphorylation
  267. Regulation of Phosphatidylinositol 3โ€“kinase by insulin in rat skeletal muscle
  268. โ€ฆ p120: demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and Phosphatidylinositol 3โ€“kinase
  269. Evidence for a role of Phosphatidylinositol 3โ€“kinase in the regulation of glucose transport in Xenopus oocytes.
  270. โ€ฆ Stimulates the Tyrosine Phosphorylation of the Insulin Receptor Substrate-1 and Its Association with Phosphatidylinositol 3โ€“kinase in Primary Adipocytes (โˆ—)
  271. Modification of the 85-kilodalton subunit of Phosphatidylinositolโ€“3 kinase in platelet-derived growth factor-stimulated cells
  272. Regulation of insulin receptor, insulin receptor substrate-1 and Phosphatidylinositol 3โ€“kinase in 3T3-F442A adipocytes. Effects of differentiation, insulin, and โ€ฆ
  273. IL-2 binding activates a tyrosine-phosphorylated Phosphatidylinositolโ€“3โ€“kinase.
  274. Phosphatidylinositol 3โ€“kinase and the actin network are not required for the stimulation of glucose transport caused by mitochondrial uncoupling: comparison with โ€ฆ
  275. Extracellular human immunodeficiency virus type-1 Tat protein activates Phosphatidylinositol 3โ€“kinase in PC12 neuronal cells
  276. Evidence that protein tyrosine kinase p56-Lck regulates the activity of Phosphatidylinositolโ€“3โ€˜-kinase in interleukin-2-dependent T-cells.
  277. Association of IRS-1 with the insulin receptor and the Phosphatidylinositol 3โ€˜-kinase. Formation of binary and ternary signaling complexes in intact cells.
  278. Differential effects of okadaic acid on insulin-stimulated glucose and amino acid uptake and Phosphatidylinositol 3โ€“kinase activity
  279. โ€ฆ a mitogen-activated protein kinase (ERK2) by the 5-hydroxytryptamine1A receptor is sensitive not only to inhibitors of Phosphatidylinositol 3โ€“kinase, but to an โ€ฆ
  280. Association of Phosphatidylinositol 3โ€“kinase, via the SH2 domains of p85, with focal adhesion kinase in polyoma middle t-transformed fibroblasts
  281. SH2-dependent association of Phosphatidylinositol 3โ€˜-kinase 85-kDa regulatory subunit with the interleukin-2 receptor beta chain.
  282. Association between Phosphatidylinositolโ€“3 kinase, Cbl and other tyrosine phosphorylated proteins in colony-stimulating factor-1-stimulated macrophages
  283. Phosphatidylinositolโ€“3โ€“kinase activity is required for the anti-Ig-mediated growth inhibition of a human B-lymphoma cell line
  284. Role of p85 subunit of Phosphatidylinositolโ€“3โ€“kinase as an adaptor molecule linking the insulin receptor, p62, and GTPase-activating protein.
  285. Interactions of polyomavirus middle T with the SH2 domains of the pp85 subunit of Phosphatidylinositolโ€“3โ€“kinase
  286. Association of activated Phosphatidylinositol 3โ€“kinase with p120cbl in antigen receptor-ligated B cells
  287. The alpha-type 85-kDa subunit of Phosphatidylinositol 3โ€“kinase is phosphorylated at tyrosines 368, 580, and 607 by the insulin receptor.
  288. Inhibition of Phosphatidylinositolโ€“3โ€ฒ-kinase Prevents Induction of Endotoxin Tolerancein Vitro
  289. Synthesis and in Vitro Evaluation of New Wortmannin Esters:โ€‰ Potent Inhibitors of Phosphatidylinositol 3โ€“kinase
  290. Schizosaccharomyces pombe Vps34p, a Phosphatidylinositol-specific PI 3โ€“kinase essential for normal cell growth and vacuole morphology
  291. Effects of growth factors on Phosphatidylinositolโ€3 kinase in astroglial cells
  292. โ€ฆ -like growth factor induces phosphorylation of immunoreactive insulin receptor substrate and its association with Phosphatidylinositolโ€“3 kinase in human thymocytes.
  293. Phosphatidylinositol 3โ€ฒโ€kinase associates with p145cโ€kit as part of a cell type characteristic multimeric signalling complex.
  294. The Phosphatidylinositol 3โ€“kinase inhibitor, wortmannin, inhibits insulin-induced activation of phosphatidylcholine hydrolysis and associated protein kinase C โ€ฆ
  295. Characterization of the bovine brain cytosolic Phosphatidylinositol 3โ€“kinase complex
  296. Phosphatidylinositol 3โ€“kinase activity is required for the activation process of focal adhesion kinase by platelet-derived growth factor
  297. Structure of a specific peptide complex of the carboxyโ€terminal SH2 domain from the p85 alpha subunit of Phosphatidylinositol 3โ€kinase.
  298. โ€ฆ characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase C gamma 1, Grb2, and Phosphatidylinositol 3โ€“kinase.
  299. Specific activity of Phosphatidylinositol 3โ€“kinase is increased by insulin stimulation
  300. Mutations in the juxtamembrane region of the insulin receptor impair activation of Phosphatidylinositol 3โ€“kinase by insulin
  301. CD38-mediated growth suppression of B-cell progenitors requires activation of Phosphatidylinositol 3โ€“kinase and involves its association with the protein product of โ€ฆ
  302. Signal transduction by the hepatocyte growth factor receptor, c-met. Activation of the Phosphatidylinositol 3โ€“kinase.
  303. Transformation-defective mutants of polyomavirus middle T antigen associate with Phosphatidylinositol 3โ€“kinase (PI 3โ€“kinase) but are unable to maintain wild-type โ€ฆ
  304. Structural features of the colonyโ€stimulating factor 1 receptor that affect its association with Phosphatidylinositol 3โ€kinase.
  305. Activation of Na+/H+ exchange by platelet-derived growth factor involves Phosphatidylinositol 3โ€˜-kinase and phospholipase C gamma.
  306. Disruption of GLUT1 glucose carrier trafficking in L6E9 and Sol8 myoblasts by the Phosphatidylinositol 3โ€“kinase inhibitor wortmannin
  307. Phosphatidylinositolโ€“3 kinase in fission yeast: a possible role in stress responses
  308. Insulin-dependent formation of a complex containing an 85-kDa subunit of Phosphatidylinositol 3โ€“kinase and tyrosine-phosphorylated insulin receptor โ€ฆ
  309. Regulation by insulin of Phosphatidylinositol 3โ€˜-kinase bound to alpha-and beta-isoforms of p85 regulatory subunit.
  310. Herbimycin A inhibits the association of p60v-src with the cytoskeletal structure and with Phosphatidylinositol 3โ€˜kinase.
  311. Novel quinone antiproliferative inhibitors of Phosphatidylinositolโ€“3โ€“kinase.
  312. โ€ฆ and insulin-like growth factor-I actions in the bovine luteal cell: regulation of receptor tyrosine kinase activity, Phosphatidylinositolโ€“3โ€“kinase, and deoxyribonucleic acid โ€ฆ
  313. Oncostatin M activates Phosphatidylinositolโ€“3โ€“kinase in Kaposiโ€™s sarcoma cells.
  314. Interleukin 2-and polyomavirus middle T antigen-induced modification of Phosphatidylinositol 3โ€“kinase activity in activated T lymphocytes
  315. Erythropoietin induces the association of Phosphatidylinositol 3โ€ฒโ€kinase with a tyrosineโ€phosphorylated protein complex containing the erythropoietin receptor
  316. Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by Phosphatidylinositol 3โ€“kinase and inhibited by cyclic AMP
  317. In vitro association of Phosphatidylinositol 3โ€“kinase activity with the activated insulin receptor tyrosine kinase.
  318. Phosphatidylinositol 3โ€kinase activity is not essential for CD28 costimulatory activity in Jurkat T cells: studies with a selective inhibitor, wortmannin
  319. Effect of epidermal growth factor on Phosphatidylinositol 3โ€“kinase activity in rabbit corneal epithelial cells
  320. Insulin-stimulated Phosphatidylinositol 3โ€“kinase activity and 2-deoxy-D-glucose uptake in rat skeletal muscles
  321. Activation and nuclear translocation of mitogen-activated protein kinases by polyomavirus middle-T or serum depend on Phosphatidylinositol 3โ€“kinase
  322. Localization of mRNA for Phosphatidylinositol 3โ€“kinase in brain of developing and mature rats
  323. Phosphatidylinositol 3โ€“kinase inhibitor, wortmannin, inhibits 5-hydroxytryptamine-mediated potentiation of platelet aggregation induced by epinephrine.
  324. The human gene encoding Phosphatidylinositolโ€“3 kinase associated p85ฮฑ is at chromosome region 5q12โ€“13
  325. Role of p85 subunit of Phosphatidylinositolโ€“3โ€“kinase as an adaptor molecule linking the insulin receptor to insulin receptor substrate 1.
  326. An 11-Amino Acid Sequence from c-met Initiates Epithelial Chemotaxis via Phosphatidylinositol 3โ€“kinase and Phospholipase C (โˆ—)
  327. Specific binding of Fyn and Phosphatidylinositol 3โ€kinase to the B cell surface glycoprotein CD19 through their src homology 2 domains
  328. โ€ฆ Interfere with Chemoattractant-induced Respiratory Burst in Neutrophils as a Result of the Inhibition of Phosphatidylinositol 3โ€“kinase Rather than Receptor โ€ฆ
  329. Differential effects of spermine on Phosphatidylinositol 3โ€“kinase and Phosphatidylinositol phosphate 5-kinase
  330. Angiotensin II induces tyrosine phosphorylation of insulin receptor substrate 1 and its association with Phosphatidylinositol 3โ€“kinase in rat heart
  331. Cooperation of Src homology domains in the regulated binding of Phosphatidylinositol 3โ€“kinase: a role for the Src homology 2 domain
  332. Evidence for a role of Phosphatidylinositol 3โ€“kinase in IL-4-induced germline Cฯต transcription
  333. Lovastatin inhibits platelet-derived growth factor (PDGF) stimulation of Phosphatidylinositol 3โ€“kinase activity as well as association of p85 subunit to tyrosine โ€ฆ
  334. Hepatocyte growth factor-induced proliferation of primary hepatocytes is mediated by activation of Phosphatidylinositol 3โ€“kinase
  335. Platelet-derived growth factor activates membrane-associated Phosphatidylinositol 3โ€“kinase and mediates its translocation from the cytosol. Detection of โ€ฆ
  336. Mutations in the SH3 domain of the src oncogene which decrease association of Phosphatidylinositol 3โ€˜-kinase activity with pp60v-src and alter cellular morphology
  337. T cell receptor-associated alpha-Phosphatidylinositol 3โ€“kinase becomes activated by T cell receptor cross-linking and requires pp56lck.
  338. โ€ฆ of the free catalytic p110 alpha and the complexed heterodimeric p110 alpha. p85 alpha forms of the mammalian Phosphatidylinositol 3โ€“kinase.
  339. Translocation, Activation and Association of Proteinโ€tyrosine kinase (p72syk) with Phosphatidylinositol 3โ€kinase are Early Events During Platelet Activation
  340. Molecular cloning of an amphibian insulin receptor substrate 1-like cDNA and involvement of Phosphatidylinositol 3โ€“kinase in insulin-induced Xenopus oocyte โ€ฆ
  341. โ€ฆ colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and Phosphatidylinositol 3โ€˜-kinase.
  342. Thrombin-stimulated immunoprecipitation of Phosphatidylinositol 3โ€“kinase from human platelets.
  343. Regulation of phosphoinositide kinases in T cells. Evidence that Phosphatidylinositol 3โ€“kinase is not a substrate for T cell antigen receptor-regulated tyrosine โ€ฆ
  344. Both CD28 ligands CD80 (B7-1) and CD86 (B7-2) activate Phosphatidylinositol 3โ€“kinase, and wortmannin reveals heterogeneity in the regulation of T cell IL-2 โ€ฆ
  345. Enhanced gene expression for Phosphatidylinositol 3โ€“kinase in the hypoglossal motoneurons following axonal crush
  346. Phosphatidylinositol 3โ€“kinase
  347. Agonist-induced association of the p21rasGTPase-activating protein with Phosphatidylinositol 3โ€“kinase
  348. Insulin induces a change in Rab5 subcellular localization in adipocytes independently of Phosphatidylinositol 3โ€“kinase activation
  349. Cytoplasmic and nuclear localization sites of Phosphatidylinositol 3โ€“kinase in human osteosarcoma sensitive and multidrug-resistant Saos-2 cells
  350. Functional interactions of Phosphatidylinositol 3โ€“kinase with GTPase-activating protein in 3T3-L1 adipocytes
  351. Phosphatidylinositolโ€“3โ€ฒ kinase is not required for mitogenesis or internalization of the Flt3/Flk2 receptor tyrosine kinase
  352. โ€ฆ a cysteine residue in polyomavirus middle T antigen abolishes interactions with protein phosphatase 2A, pp60c-src, and Phosphatidylinositolโ€“3 kinase, activation of c โ€ฆ
  353. Potent activation of Phosphatidylinositol 3โ€˜-kinase by simple phosphotyrosine peptides derived from insulin receptor substrate 1 containing two YMXM motifs for โ€ฆ
  354. The insulin-elicited 60-kDa phosphotyrosine protein in rat adipocytes is associated with Phosphatidylinositol 3โ€“kinase.
  355. Specific association of Phosphatidylinositol 3โ€kinase with the protooncogene product Cbl in Fcฮณ receptor signaling
  356. Insulin and dexamethasone regulate insulin receptors, insulin receptor substrate-1, and Phosphatidylinositol 3โ€“kinase in Fao hepatoma cells
  357. Phosphatidylinositol 3โ€“kinase activity in murine erythroleukemia cells during DMSO-induced differentiation
  358. Activation of Src-family protein tyrosine kinases and Phosphatidylinositol 3โ€“kinase in 3T3-L1 mouse preadipocytes by interleukin-11.
  359. The level of insulin receptor tyrosine kinase activity modulates the activities of Phosphatidylinositol 3โ€“kinase, microtubule-associated protein, and S6 kinases.
  360. Wortmannin inhibits insulin secretion in pancreatic islets and ฮฒ-TC3 cells independent of its inhibition of Phosphatidylinositol 3โ€“kinase
  361. โ€ฆ derived growth factor triggers translocation of the insulin-regulatable glucose transporter (type 4) predominantly through Phosphatidylinositol 3โ€“kinase binding sites on โ€ฆ
  362. Induction of activator protein (AP)-1 and nuclear factor-kappaB by CD28 stimulation involves both Phosphatidylinositol 3โ€“kinase and acidic sphingomyelinase signals.
  363. CD28-mediated up-regulation of beta 1-integrin adhesion involves Phosphatidylinositol 3โ€“kinase.
  364. The HIV-1 Nef Protein Interferes with Phosphatidylinositol 3โ€“kinase Activation 1 (โˆ—)
  365. Monocyte Colony-stimulating Factor Stimulates Binding of Phosphatidylinositol 3โ€“kinase to Grb2ยท Sos Complexes in Human Monocytes
  366. The protein product of the proto-oncogene c-cbl forms a complex with Phosphatidylinositol 3โ€“kinase p85 and CD19 in anti-IgM-stimulated human B-lymphoma โ€ฆ
  367. Potentiation of insulin stimulation of Phosphatidylinositol 3โ€“kinase by thiazolidinedione-derived antidiabetic agents in Chinese hamster ovary cells expressing human โ€ฆ
  368. Modulation of the substrate specificity of the mammalian Phosphatidylinositol 3โ€“kinase by cholesterol sulfate and sulfatide
  369. Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of Phosphatidylinositol 3โ€“kinase
  370. Involvement of Phosphatidylinositol 3โ€“kinase in stimulation of glucose transport by growth factors in 3T3-L1 adipocytes.
  371. 17ฮฒ-hydroxywortmannin: A potent inhibitor of bone resorption and Phosphatidylinositolโ€“3โ€“kinase
  372. Activation of Phosphatidylinositolโ€“3โ€“kinase by platelet-derived growth factor and insulin-like growth factor-1 is inhibited by a transmembrane phosphotyrosine โ€ฆ
  373. CD28-mediated cytotoxicity by the human leukemic NK cell line YT involves tyrosine phosphorylation, activation of Phosphatidylinositol 3โ€“kinase, and protein kinase C โ€ฆ
  374. Association of Phosphatidylinositol 3 kinase to protein kinase C ฮถ during interleukinโ€2 stimulation
  375. Interaction of the molecular weight 85K regulatory subunit of the Phosphatidylinositol 3โ€“kinase with the insulin receptor and the insulin-like growth factor-1 (IGF-I) โ€ฆ
  376. A tyrosine kinase signaling pathway accounts for the majority of Phosphatidylinositol 3, 4, 5-trisphosphate formation in chemoattractant-stimulated human โ€ฆ
  377. Phorbol ester treatment inhibits Phosphatidylinositol 3โ€“kinase activation by, and association with, CD28, a T-lymphocyte surface receptor.
  378. Chromosomal localization of human p85 alpha, a subunit of Phosphatidylinositol 3โ€“kinase, and its homologue p85 beta.
  379. Phosphatidylinositol 3โ€ฒ-kinase, but not p70 ribosomal S6 kinase, is involved in membrane protein recycling: wortmannin inhibits glucose transport and โ€ฆ
  380. Gastrin stimulates tyrosine phosphorylation of insulin receptor substrate 1 and its association with Grb2 and the Phosphatidylinositol 3โ€“kinase
  381. Identification of amino acid residues required for a specific interaction between Src-tyrosine kinase and proline-rich region of Phosphatidylinositolโ€“3โ€ฒ kinase
  382. Studies with wortmannin suggest a role for Phosphatidylinositol 3โ€“kinase in the activation of glycogen synthase and mitogen-activated protein kinase by insulin in rat โ€ฆ
  383. Insulin treatment stimulates the tyrosine phosphorylation of the alpha-type 85-kDa subunit of Phosphatidylinositol 3โ€“kinase in vivo.
  384. NMR Analysis of Interactions of a Phosphatidylinositol 3 โ€˜-kinase SH2 Domain with Phosphotyrosine Peptides Reveals Interdependence of Major Binding Sites
  385. Endotoxin tolerance alters phospholipase C-ฮณ1 and Phosphatidylinositolโ€“3โ€ฒ-kinase expression in peritoneal macrophages
  386. โ€ฆ cytoplasmic domain of the interleukin-2 receptor beta chain is essential for interleukin-2-dependent tyrosine protein kinase and Phosphatidylinositolโ€“3โ€“kinase โ€ฆ
  387. Phosphatidylinositolโ€“3โ€“kinase is a non-tyrosine phosphorylated member of the insulin receptor signalling complex
  388. Activation of Phosphatidylinositolโ€“3โ€“kinase by insulin is mediated by both A and B human insulin receptor types
  389. CD28 co-stimulatory regimes differ in their dependence on Phosphatidylinositol 3โ€“kinase: common co-signals induced by CD80 and CD86
  390. Naturally occurring etherโ€linked phosphatidylcholine activates Phosphatidylinositol 3โ€kinase and stimulates cell growth
  391. โ€ฆ colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with Phosphatidylinositol 3โ€“kinase, or induction of c โ€ฆ
  392. Interleukin-4 induces association of the c-fes proto-oncogene product with Phosphatidylinositolโ€“3 kinase
  393. Cyclic peptide inhibitors of Phosphatidylinositol 3โ€“kinase p85 SH2 domain binding
  394. Studies of partially transforming polyomavirus mutants establish a role for Phosphatidylinositol 3โ€“kinase in activation of pp70 S6 kinase
  395. Lysophosphatidic acid stimulates glucose transport in Xenopus oocytes via a Phosphatidylinositol 3โ€ฒ-kinase with distinct properties
  396. Phosphatidylinositol 3-OH kinase activity is not required for activation of mitogen-activated protein kinase by cytokines
  397. Growth factor-regulated Phosphatidylinositolโ€“3โ€“kinase in astrocytes. Involvement of pp60c-Src.
  398. Selective inhibition of Phosphatidylinositol 3โ€“kinase by phosphatidic acid and related lipids
  399. Evidence of the Involvement of Phosphatidylinositol 3โ€“kinase in the Migration, Actin Stress Fiber Formation, and ฮฑvฮฒ3-Integrinโ€“Mediated Adherence of Human โ€ฆ
  400. The effects of wortmannin, a potent inhibitor of Phosphatidylinositol 3โ€“kinase, on insulin-stimulated glucose transport, GLUT4 translocation, antilipolysis, and DNA โ€ฆ
  401. Phosphatidylinositol 3โ€“kinase binding to polyoma virus middle tumor antigen mediates elevation of glucose transport by increasing translocation of the GLUT1 โ€ฆ
  402. Phosphatidylinositol 3โ€“kinase participates in p56 (lck)/CD4-dependent down-regulation of LFA-1-mediated T cell adhesion.
  403. Wortmannin, a specific inhibitor of Phosphatidylinositolโ€“3โ€“kinase, inhibits erythropoietin-induced erythroid differentiation of K562 cells.
  404. Interleukin-4 (IL-4) induces protein tyrosine phosphorylation of the IL-4 receptor and association of Phosphatidylinositol 3โ€“kinase to the IL-4 receptor in a mouse T cell โ€ฆ
  405. Mammalian Phosphatidylinositol 3โ€ฒโ€kinase induces a lethal phenotype on expression in Schizosaccharomyces pombe; comparison with the VPS34 gene product
  406. A role for Phosphatidylinositol 3โ€“kinase in generating T cell help for B cell growth and differentiation.
  407. Insulin Stimulates Phosphatidylinositol 3โ€kinase Activity in Rat Neuronal Primary Cultures
  408. Comparison of CD28โ€B7. 1 and B7. 2 functional interaction in resting human T cells: Phosphatidylinositol 3โ€kinase association to CD28 and cytokine production
  409. Tyrosine 508 of the 85-kilodalton subunit of Phosphatidylinositol 3โ€“kinase is phosphorylated by the platelet-derived growth factor receptor
  410. Interleukin 7 receptor mediates the activation of Phosphatidylinositolโ€“3 kinase in human B-cell precursors
  411. Association of Phosphatidylinositol 3โ€kinase with the photoโ€oncogene product Cbl upon CD38 ligation by a specific monoclonal antibody in THPโ€1 cells
  412. Regulation of CD4-p561ck-associated Phosphatidylinositol 3โ€“kinase (PI 3โ€“kinase) and Phosphatidylinositol 4-kinase (PI 4-kinase)
  413. โ€ฆ in downstream signaling pathways of p185BCR-ABL in Ph+ ALL involve GTPase-activating protein, phospholipase C-gamma 1, and Phosphatidylinositol 3โ€˜-kinase.
  414. โ€ฆ That Signals DNA Synthesis in NIH 3T3 Cells Specifically Binds a Complex of Src and Janus Family Tyrosine kinases and Phosphatidylinositol 3โ€“kinase (โˆ—)
  415. Anti-phosphotyrosine immunoprecipitation of Phosphatidylinositol 3โ€ฒ kinase activity in different cell types after exposure to epidermal growth factor
  416. โ€ฆ B cell antigen receptor-related structure of pre-B cell lines induces tyrosine phosphorylation of p85 and p110 subunits and activation of Phosphatidylinositol 3โ€“kinase
  417. The Gene That Encodes the Phosphatidylinositolโ€“3 kinase Regulatory Subunit (p85ฮฑ) Maps to Chromosome 13 in the Mouse
  418. The catalytic subunit of Phosphatidylinositol 3โ€“kinase is a substrate for the activated platelet-derived growth factor receptor, but not for middle-T antigen-pp60c-src โ€ฆ
  419. Phosphatidylinositol 3 kinase activity is not essential for B7-1-mediated costimulation of proliferation or development of cytotoxicity in murine T cells.
  420. Effects of phorbol esters on insulinโ€induced activation of Phosphatidylinositol 3โ€kinase, glucose transport, and glycogen synthase in rat adipocytes
  421. The E5 gene product of rhesus papillomavirus is an activator of endogenous Ras and Phosphatidylinositolโ€“3โ€ฒ-kinase in NIH 3T3 cells
  422. โ€ฆ by mutation of the tyrosine residues in the insulin receptor substrate-1 affecting association with the tyrosine phosphatase 2C and Phosphatidylinositol 3โ€“kinase
  423. โ€ฆ site mutants in the murine colony-stimulating factor-1 receptor are unaffected in their ability to bind or phosphorylate Phosphatidylinositolโ€“3 kinase but show differential โ€ฆ
  424. Insulin-like growth factor-1 stimulation of cells induces formation of complexes containing Phosphatidylinositolโ€“3โ€“kinase, guanosine triphosphatase-activating protein โ€ฆ
  425. Phosphatidylinositol 3โ€“kinase
  426. Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and Phosphatidylinositol-specific PI 3โ€“kinase โ€ฆ
  427. Wortmannin-mediated inhibition of Phosphatidylinositol 3โ€“kinase activity triggers apoptosis in normal and neoplastic B lymphocytes which are in cell cycle
  428. โ€ฆ in 32D cells requires insulin receptor, Shc, and mitogen-activated protein kinase, but not insulin receptor substrate-1 and Phosphatidylinositol 3โ€“kinase โ€ฆ
  429. โ€ฆ exerts a full insulin-like effect on glucose transport and glucose transporter 4 translocation in human adipocytes: evidence for a Phosphatidylinositol 3โ€“kinase โ€ฆ
  430. Phosphatidylinositol 3โ€“kinase: inhibition of intrinsic protein-serine kinase activity by phosphoinositides, and of lipid kinase activity by Mn2+
  431. Alternative binding of p56lck and Phosphatidylinositol 3โ€“kinase in T cells by sulfhydryl oxidation: implication of aberrant signaling due to oxidative stress in T โ€ฆ
  432. Effect of IGF-I on Phosphatidylinositol 3โ€“kinase in soleus muscle of lean and insulin-resistant obese mice
  433. Activation of Phosphatidylinositol 3โ€“kinase and Phosphatidylinositol 4-kinase during rat parotid acinar cell proliferation
  434. A product of Phosphatidylinositolโ€“3 kinase is elevated in dividing HT29 colonic epithelial cells
  435. Phosphorylation in vitro of the 85 kDa subunit of Phosphatidylinositol 3โ€“kinase and its possible activation by insulin receptor tyrosine kinase
  436. Structure-activity studies of phosphorylated peptide inhibitors of the association of Phosphatidylinositol 3โ€“kinase with PDGF-ฮฒ receptor
  437. Mitogenic inhibition by phorbol esters is associated with decreased Phosphatidylinositolโ€“3 kinase activation
  438. Structure of 85 kDa subunit of human Phosphatidylinositol 3โ€kinase analyzed by using monoclonal antibodies
  439. Activation of Phosphatidylinositol 3โ€“kinase by concanavalin A through dual signaling pathways, G-protein-coupled and phosphotyrosine-related, and an essential role โ€ฆ
  440. Rapid and efficient purification of Src homology 2 domain-containing proteins: Fyn, Csk and Phosphatidylinositol 3โ€“kinase p85
  441. Activation of Akt by nerve growth factor via Phosphatidylinositolโ€“3 kinase in PC12 pheochromocytoma cells
  442. SH3 domain-mediated dimerization of an n-terminal fragment of the Phosphatidylinositol 3โ€“kinase p85 subunit
  443. EFFECT OF LOVASTATIN AND FLUOROMEVALONATE ON Phosphatidylinositol 3โ€kinase ACTIVITY STIMULATED WITH PDGF
  444. โ€ฆ factor induces the tyrosine phosphorylation and activation of phospholipase C-gamma 1, Fyn and Lyn kinases, and Phosphatidylinositol 3โ€“kinase in a human B cell โ€ฆ
  445. Protein kinase C-mediated formation of Phosphatidylinositol 3, 4-bisphosphate in human platelets
  446. EJ-Ras Inhibits Phospholipase Cฮณ1 but Not Actin Polymerization Induced by Platelet-Derived Growth Factor-BB via Phosphatidylinositol 3โ€“kinase
  447. Controlled overexpression of selected domains of the P85 subunit of Phosphatidylinositol 3โ€“kinase reverts v-Ha-Ras transformation
  448. Insulin-like growth factor-1-mediated association of p85 Phosphatidylinositol 3โ€“kinase with pp 185: requirement of SH2 domains for in vivo interaction.
  449. The differential activation of Phosphatidylinositolโ€“3 kinase and mitogen-activated protein kinases by PDGF-AA and IGF-I might explain the synergistic effect of the two โ€ฆ
  450. CD28โ€dependent killing by human YT cells requires Phosphatidylinositol 3โ€kinase activation
  451. Phosphoinositide 3-phosphatase segregates from Phosphatidylinositol 3โ€“kinase in EGF-stimulated A431 cells and fails to in vitro hydrolyse Phosphatidylinositol (3, 4 โ€ฆ
  452. โ€ฆ p21ras-mediated signaling is independent of platelet-derived growth factor receptor interaction with GTPase-activating protein or Phosphatidylinositolโ€“3โ€“kinase.
  453. Synthesis of Phosphatidylinositol 3, 4-bisphosphate is regulated by protein-tyrosine phosphorylation but the p85ฮฑ subunit of Phosphatidylinositol 3โ€“kinase may not be โ€ฆ
  454. Peptide antisera to human colony-stimulating factor 1 receptor detect ligand-induced conformational changes and a binding site for Phosphatidylinositol 3โ€“kinase
  455. Inhibition of IGF II-induced redistribution of mannose 6-phosphate receptors by the Phosphatidylinositol 3โ€“kinase inhibitor, wortmannin
  456. A novel pathway for the formation of Phosphatidylinositol 3, 4-bisphosphate. Phosphorylation of Phosphatidylinositol 3-monophosphate by โ€ฆ
  457. Novel protein kinase/Phosphatidylinositol 3โ€“kinase complex essential for receptor-mediated protein sorting to the vacuole in yeast
  458. Haematopoietic colony stimulating factors CSF-1 and GM-CSF increase Phosphatidylinositol 3โ€“kinase activity in murine bone marrow-derived macrophages
  459. Isolation of the active form of RACโ€protein kinase (PKB/Akt) from transfected COSโ€7 cells treated with heat shock stress and effects of Phosphatidylinositol 3, 4, 5 โ€ฆ
  460. Association of the insulin receptor and Phosphatidylinositol 3โ€“kinase requires a third component
  461. Interleukin-4 activates two distinct pathways of Phosphatidylinositolโ€“3 kinase in the same cells
  462. Dominant negative effect of the truncated p110 subunit of Phosphatidylinositolโ€3 kinase
  463. โ€ฆ FTI-244 decreases platelet-derived growth factor receptor tyrosine phosphorylation levels and inhibits stimulation of Phosphatidylinositol 3โ€“kinase but not mitogen โ€ฆ
  464. Inhibition of Neuroblastoma Cell Phosphatidylinositol 3โ€kinase by CDPโ€Diacylglycerol and Phosphatidate
  465. Regulation of Phosphatidylinositolโ€“3 kinase by tyrosyl phosphoproteins
  466. D-myo-Inositol 1, 4, 5-trisphosphate analogues modified at the 3-position inhibit Phosphatidylinositol 3โ€“kinase
  467. Detection of a 60 kDa tyrosine-phosphorylated protein in insulin-stimulated hepatoma cells that associates with the SH2 domain of Phosphatidylinositol 3โ€“kinase
  468. Serine-rich region of the IL-2 receptor ฮฒ-chain is required for activation of Phosphatidylinositol 3โ€“kinase
  469. In vitro association of the Phosphatidylinositol 3โ€kinase regulatory subunit (p85) with the human insulin receptor
  470. Phosphatidylinositol 3โ€“kinase is involved in TRE-dependent gene expression in response to arginine vasopressin
  471. Dissociation of Phosphatidylinositolโ€“3 kinase activity and mitogenic inhibition in vascular smooth muscle cells
  472. โ€ฆ H2O2 and vanadate enhances insulin receptor mediated tyrosine phosphorylation of IRSโ€1 leading to IRSโ€1 association with the Phosphatidylinositol 3โ€kinase
  473. Characterization of a Phosphatidylinositol-specific phosphoinositide 3โ€“kinase from mammalian cells
  474. Insulin-dependent Phosphatidylinositol 3โ€ฒ-kinase activity co-precipitates with insulin receptor in human circulating mononuclear cells
  475. Phosphatidylinositol (PI) 3โ€“kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3โ€“kinase but not PI 4-kinase
  476. O-17: Overexpression of a constitutively active form of Phosphatidylinositol 3 kinase is sufficient to Promote GLUT 4 translocation in transfected rat adipose cells
  477. Platelet-Derived Growth Factor Induces Phosphatidylinositol 3โ€“kinase Release from the Middle T-pp60c-src Complex and Association with the Platelet-Derived โ€ฆ
  478. Phosphatidylinositol 3โ€“kinase: A Novel Signal Transduction Pathway?
  479. Up-regulation of Expression of Phosphatidylinositol 3โ€“kinase in Psoriatic Lesions
  480. A Phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3โ€“kinase homologs โ€ฆ
  481. Differential roles of Phosphatidylinositol 3โ€“kinase in mitogen-activated prote in kinase activation by insulin and epidermal growth factor
  482. Production of monoclonal antibodies specific to the carboxyl terminal region of the 85 kDa subunit of Phosphatidylinositol 3โ€kinase: Use of the antibodies in โ€ฆ
  483. Phosphatidylinositol 3โ€“kinase is involved in the colony-stimulating factor-1-induced spreading of macrophages and osteoclasts.
  484. Purification of Phosphatidylinositol 3โ€“kinase by SDS-agarose gel electrophoresis and HPEC
  485. Does Phosphatidylinositol 3โ€kinase play a role in insulinโ€induced outgrowth of pseudopodial cables in cultured cells derived from micromeres of sea urchin embryos?
  486. Phosphatidylinositolโ€“3โ€“kinase Pathway is Stimulated by Fungal Lipid Containing Cocoa Butter Equivalents (CBE) in FMet-Leu-Phe (FMLP)-and Phorbolester (PMA) โ€ฆ
  487. A structural and functional analysis of the Phosphatidylinositol 3โ€“kinase
  488. Engagement of the osteoclast integrin alpha v beta 3 by osteopontin stimulates Phosphatidylinositol 3-hydroxyl kinase activity
  489. O-49: A prevalent amino acid polymorphism at codon 325Met-> IIe in the gene encoding the Phosphatidylinositol 3โ€“kinase p85ฮฑ regulatory subunit is associated with โ€ฆ
  490. Activation of PRK1 by Phosphatidylinositol 4, 5-Bisphosphate and Phosphatidylinositol 3, 4, 5-Trisphosphate: A COMPARISON WITH PROTEIN kinase C โ€ฆ
  491. Characterization of tyrosine kinase-associated Phosphatidylinositolโ€“3 kinase.
  492. The experimental study on Phosphatidylinositol 3โ€“kinase/Akt in neural stem cells in vitro
  493. Phosphatidylinositol 3โ€“kinase activation by IGF-I is independent of irs-1 in hl-60 cells
  494. Role of Phosphatidylinositol 3โ€“kinase in growth factor and oncogene signaling
  495. Purification and characterisation of Phosphatidylinositol 3โ€“kinase from bovine brain
  496. CD19 and Phosphatidylinositol 3โ€“kinase
  497. Activation of Phosphatidylinositol 3โ€“kinase in hepatocyte growth and hepatocellular transformation
  498. Phosphatidylinositol 3โ€“kinase (PI3k) is required for chemoattractant-stimulated homotypic aggregation of human neutropfflls
  499. Shear stress-induced signal transduction through Phosphatidylinositolโ€“3 kinase in endothelial cells
  500. Early events in insulin signaling: Tyrosine phosphorylation and Phosphatidylinositol 3โ€“kinase activation
  501. Profilin and gelsolin stimulate Phosphatidylinositol 3โ€“kinase activity
  502. Phosphatidylinositol 3โ€“kinase Activity in 3T3-L1 Adipocytes: Effects of Pioglitazone on Insulin-and IGF-1-Stimulated Cells
  503. Phosphatidylinositol 3โ€“kinase Activity Is Required for Hepatocyte Growth Factor-induced Mitogenic Signals in Epithelial Cells
  504. Role of Phosphatidylinositol 3โ€“kinase during the first cell cycles of the sea urchin embryo. Effect on map kinase and MPF activities.
  505. P-62: Role of Phosphatidylinositolโ€“3โ€“kinase and S6 kinase in insulin-stimulated glycogen synthesis
  506. The effects of fluid shear stress on the activity of protein kinase C, Phosphatidylinositol 3โ€“kinase and Rho in aortic endothelial cells
  507. Role of p38 and Phosphatidylinositol 3 kinase (PI3K) in the signal transduction of apoptosis of activated human?? T cells induced by restimulating with Mycobacterium โ€ฆ
  508. Phosphatidylinositol 3 kinase (PI 3 K) regulates glomerular mesangial cell chemotaxis and proliferation: Involvement of mitogen activated protein kinase (MAPK) โ€ฆ
  509. Phosphatidylinositol 3โ€“kinase regulates actin stress fiber formation and the avidity of the integrin-receptor ฮฑ, ฮฒ 3 in human melanoma cells.
  510. Regulation of early endosomal transport and fusion by ADP-ribosylation factors and Phosphatidylinositol 3โ€“kinase
  511. P-78: Role of p85 isoforms of Phosphatidylinositolโ€“3โ€“kinase in insulin receptor signaling
  512. Translocation of Phosphatidylinositolโ€“3 kinase (PI3โ€“kinase) and small GTPase Rho A to the cytoskeleton upon osteoclast attachment to bone.
  513. Phosphatidylinositol 3โ€“kinase regulates actin stress fiber formation and the avidity of the integrin-receptor ฮฑvฮฒ3 in human melanoma cells.
  514. Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of Phosphatidylinositol (PI) 3โ€“kinase and for c-kit-associated PI 3โ€“kinase activity in โ€ฆ
  515. โ€ฆ derived growth factor triggers translocation of the insulin-regulatable glucose transporter (type 4) predominantly through Phosphatidylinositol 3โ€“kinase binding sites on โ€ฆ
  516. P-77: Insulinomimetic agent, vanadyl sulfate (VS)-stimulated Phosphatidylinositol 3โ€“kinase (PI 3-K) and RAS/MAP kinase activation is independent of insulin receptor โ€ฆ
  517. Effect of phosphotyrosylโ€IRSโ€1 level and insulin receptor tyrosine kinase activity on insulinโ€stimulated Phosphatidylinositol 3, MAP, and S6 kinase activities
  518. Phosphorylation of Tyrosine 503 in the Erythropoietin Receptor (EpR) Is Essential for Binding the P85 Subunit of Phosphatidylinositol (PI) 3โ€“kinase and for โ€ฆ
  519. Protein kinase B (c-Akt): a multifunctional mediator of Phosphatidylinositol 3โ€“kinase activation
  520. A requirement for Phosphatidylinositol 3โ€“kinase in pseudopod extension
  521. Downstream signalling events regulated by Phosphatidylinositol 3โ€“kinase activity
  522. p110ฮด, a novel Phosphatidylinositol 3โ€“kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes
  523. A specific product of Phosphatidylinositol 3โ€“kinase directly activates the protein kinase Akt through its pleckstrin homology domain
  524. The role of Phosphatidylinositol 3โ€“kinase in vascular endothelial growth factor signaling
  525. Cyclin D expression is controlled post-transcriptionally via a Phosphatidylinositol 3โ€“kinase/Akt-dependent pathway
  526. Role of glycogen synthase kinaseโ€“3 in the Phosphatidylinositol 3โ€“kinase/Akt cell survival pathway
  527. Antiapoptotic signalling by the insulin-like growth factor I receptor, Phosphatidylinositol 3โ€“kinase, and Akt
  528. Calmodulin activates Phosphatidylinositol 3โ€“kinase
  529. Phosphatidylinositol 3โ€“kinase-dependent membrane association of the Brutonโ€™s tyrosine kinase pleckstrin homology domain visualized in single living cells
  530. Regulation of the p85/p110 Phosphatidylinositol 3โ€ฒ-kinase: stabilization and inhibition of the p110ฮฑ catalytic subunit by the p85 regulatory subunit
  531. Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and Phosphatidylinositol 3โ€“kinase
  532. Phosphatidylinositol 3โ€“kinase couples the interleukin-2 receptor to the cell cycle regulator E2F
  533. Ezrin, a plasma membraneโ€“microfilament linker, signals cell survival through the Phosphatidylinositol 3โ€“kinase/Akt pathway
  534. Suppression of transforming growth factor-ฮฒ-induced apoptosis through a Phosphatidylinositol 3โ€“kinase/Akt-dependent pathway
  535. Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the Phosphatidylinositol 3โ€“kinase/Akt pathway
  536. PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent Phosphatidylinositol 3โ€“kinase/Akt cell survival pathway
  537. Vascular endothelial growth factor regulates endothelial cell survival through the Phosphatidylinositol 3โ€ฒ-kinase/Akt signal transduction pathway โ€ฆ
  538. Depolarization and neurotrophins converge on the Phosphatidylinositol 3โ€“kinaseโ€“Akt pathway to synergistically regulate neuronal survival
  539. Relationship between flavonoid structure and inhibition of Phosphatidylinositol 3โ€“kinase: a comparison with tyrosine kinase and protein kinase C inhibition
  540. Myogenic signaling of Phosphatidylinositol 3โ€“kinase requires the serine-threonine kinase Akt/protein kinase B
  541. Requirement of Phosphatidylinositol 3โ€“kinase in focal adhesion kinase-promoted cell migration
  542. Identification of an early endosomal protein regulated by Phosphatidylinositol 3โ€“kinase
  543. Activation of the Phosphatidylinositol 3โ€“kinase serine kinase by IFN-alpha.
  544. The Phosphatidylinositol 3โ€kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes
  545. Constitutive activation of Phosphatidylinositol 3โ€“kinase by a naturally occurring mutant epidermal growth factor receptor
  546. Akt, a target of Phosphatidylinositol 3โ€“kinase, inhibits apoptosis in a differentiating neuronal cell line
  547. Regulation of the p85/p110ฮฑ Phosphatidylinositol 3โ€ฒ-kinase: distinct roles for the N-terminal and C-terminal SH2 domains
  548. Activated Phosphatidylinositol 3โ€“kinase and Akt kinase promote survival of superior cervical neurons
  549. Increased levels of Phosphatidylinositol 3โ€kinase activity in colorectal tumors
  550. Protein kinase C-ฮถ as a downstream effector of Phosphatidylinositol 3โ€“kinase during insulin stimulation in rat adipocytes: potential role in glucose transport
  551. Phosphatidylinositol 3โ€“kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons
  552. Phosphatidylinositol 3โ€kinaseโ€mediated regulation of neuronal apoptosis and necrosis by insulin and IGFโ€I
  553. Identification and analysis of PH domain-containing targets of Phosphatidylinositol 3โ€“kinase using a novel in vivo assay in yeast
  554. Phosphatidylinositol 3โ€“kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation
  555. Comparison of the roles of mitogen-activated protein kinase kinase and Phosphatidylinositol 3โ€“kinase signal transduction in neutrophil effector function
  556. Activation of Phosphatidylinositol 3โ€“kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-ฮบB p65/RelA subunit
  557. Induction of Vascular Endothelial Growth Factor by Hypoxia Is Modulated by a Phosphatidylinositol 3โ€“kinase/Akt Signaling Pathway in Ha-ras-Transformed Cells โ€ฆ
  558. Activation of Phosphatidylinositol 3โ€“kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation
  559. STAT3 as an adapter to couple Phosphatidylinositol 3โ€“kinase to the IFNAR1 chain of the type I interferon receptor
  560. Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires Phosphatidylinositol 3โ€“kinase
  561. Heregulin induces phosphorylation of BRCA1 through Phosphatidylinositol 3โ€“kinase/AKT in breast cancer cells
  562. Phosphatidylinositol 3โ€“kinase is required for platelet-derived growth factorโ€™s actions on hepatic stellate cells
  563. FAK is the upstream signal protein of the Phosphatidylinositol 3โ€“kinase-Akt survival pathway in hydrogen peroxide-induced apoptosis of a human โ€ฆ
  564. An essential role of Phosphatidylinositol 3โ€“kinase in myogenic differentiation
  565. Phosphatidylinositol 3โ€“kinase-ฮณ activates Brutonโ€™s tyrosine kinase in concert with Src family kinases
  566. Phosphatidylinositol 3โ€“kinase in interleukin 1 signaling: physical interaction with the interleukin 1 receptor and requirement in NFฮบB and AP-1 activation
  567. Insulin-like growth factor 1 inhibits apoptosis using the Phosphatidylinositol 3โ€ฒ-kinase and mitogen-activated protein kinase pathways
  568. The Phosphatidylinositol 3โ€ฒ-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells
  569. โ€ฆ the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions: evidence for the association of Phosphatidylinositol 3โ€“kinase with the E โ€ฆ
  570. Angiotensin II activates Phosphatidylinositol 3โ€“kinase in vascular smooth muscle cells
  571. p85ฮฑ gene generates three isoforms of regulatory subunit for Phosphatidylinositol 3โ€“kinase (PI 3โ€“kinase), p50ฮฑ, p55ฮฑ, and p85ฮฑ, with different PI 3โ€“kinase โ€ฆ
  572. Effects of free fatty acids on glucose transport and IRS-1โ€“associated Phosphatidylinositol 3โ€“kinase activity
  573. Nitric oxide stimulates skeletal muscle glucose transport through a calcium/contractionโ€“and Phosphatidylinositolโ€“3โ€“kinaseโ€“independent pathway
  574. Adenoviral gene transfer of activated Phosphatidylinositol 3โ€ฒ-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro
  575. Interleukin 8-stimulated Phosphatidylinositolโ€“3โ€“kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and โ€ฆ
  576. Differentiated phenotype of smooth muscle cells depends on signaling pathways through insulin-like growth factors and Phosphatidylinositol 3โ€“kinase
  577. The protein-tyrosine phosphatase TCPTP regulates epidermal growth factor receptor-mediated and Phosphatidylinositol 3โ€“kinase-dependent signaling
  578. Inhibition of adipose differentiation by Phosphatidylinositol 3โ€kinase inhibitors
  579. Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of Phosphatidylinositol 3โ€“kinase
  580. Midkine inhibits caspase-dependent apoptosis via the activation of mitogen-activated protein kinase and Phosphatidylinositol 3โ€“kinase in cultured neurons.
  581. Phosphatidylinositol 3โ€“kinase links the interleukin-2 receptor to protein kinase B and p70 S6 kinase
  582. Distinct roles of the Phosphatidylinositol 3โ€“kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors
  583. MAP kinases, Phosphatidylinositol 3โ€kinase, and p70 S6 kinase mediate the mitogenic response of human endothelial cells to vascular endothelial growth factor
  584. Requirement for both Shc and Phosphatidylinositol 3โ€ฒ kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis
  585. Negative regulation by Phosphatidylinositol 3โ€“kinase of inducible nitric oxide synthase expression in macrophages
  586. c-Src is required for stimulation of gelsolin-associated Phosphatidylinositol 3โ€“kinase
  587. Altered expression levels and impaired steps in the pathway to Phosphatidylinositol 3โ€“kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats
  588. Contribution of Phosphatidylinositol 3โ€kinase to radiation resistance in human melanoma cells
  589. Lysophosphatidic acid is a major serum noncytokine survival factor for murine macrophages which acts via the Phosphatidylinositol 3โ€“kinase signaling pathway.
  590. Increase in nuclear Phosphatidylinositol 3โ€kinase activity and Phosphatidylinositol (3, 4, 5) trisphosphate synthesis precede PKCโ€ฮถ translocation to the nucleus of NGF โ€ฆ
  591. Src-induced activation of inducible T cell kinase (ITK) requires Phosphatidylinositol 3โ€“kinase activity and the Pleckstrin homology domain of inducible T cell kinase
  592. Epidermal growth factor promotes MDA-MB-231 breast cancer cell migration through a Phosphatidylinositol 3โ€ฒ-kinase and phospholipase C-dependent mechanism
  593. โ€ฆ oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the Phosphatidylinositol 3โ€“kinase โ€ฆ
  594. Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cellโ€“cell adhesion or cell migration and is regulated by Phosphatidylinositol 3โ€“kinase
  595. Platelet-derived growth factor ฮฒ receptor regulates interstitial fluid homeostasis through Phosphatidylinositolโ€“3โ€ฒ kinase signaling
  596. Wortmannin, a specific inhibitor of Phosphatidylinositolโ€“3โ€“kinase, enhances LPS-induced NO production from murine peritoneal macrophages
  597. Antiapoptotic signaling in LNCaP prostate cancer cells: a survival signaling pathway independent of Phosphatidylinositol 3โ€ฒ-kinase and Akt/protein kinase B
  598. Extracellularโ€regulated kinases and Phosphatidylinositol 3โ€kinase are involved in brainโ€derived neurotrophic factorโ€mediated survival and neuritogenesis of the โ€ฆ
  599. Phosphatidylinositol 3โ€“kinase mediates mitogen-induced human airway smooth muscle cell proliferation
  600. Phosphatidylinositol 3โ€kinase is recruited to a specific site in the activated ILโ€1 receptor I
  601. Phosphatidylinositol 3โ€“kinase is a negative regulator of cellular differentiation
  602. Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of Phosphatidylinositol 3โ€ฒ-kinase and is involved in interleukin 6-induced โ€ฆ
  603. Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of Phosphatidylinositol 3โ€“kinase and Akt
  604. The Antiapoptotic Gene mcl-1 Is Up-Regulated by the Phosphatidylinositol 3โ€“kinase/Akt Signaling Pathway through a Transcription Factor Complex Containing โ€ฆ
  605. Cyclin D1 Expression Mediated by Phosphatidylinositol 3โ€“kinase through mTOR-p70S6K-Independent Signaling in Growth Factor-Stimulated NIH 3T3 Fibroblasts
  606. Regulation of vascular smooth muscle cell apoptosis: modulation of Bad by a Phosphatidylinositol 3โ€“kinaseโ€“dependent pathway
  607. Activated MEK stimulates expression of AP-1 components independently of Phosphatidylinositol 3โ€“kinase (PI3โ€“kinase) but requires a PI3โ€“kinase signal to stimulate โ€ฆ
  608. Phosphatidylinositol 3โ€“kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway
  609. Distinct Phosphatidylinositol 3โ€“kinase lipid products accumulate upon oxidative and osmotic stress and lead to different cellular responses
  610. Activation of Phosphatidylinositol 3โ€“kinase through glycoprotein 130 induces protein kinase B and p70 S6 kinase phosphorylation in cardiac myocytes
  611. Inhibition of Phosphatidylinositol 3โ€“kinase activity blocks depolarization-and insulin-like growth factor I-mediated survival of cerebellar granule cells
  612. Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via Phosphatidylinositolโ€“3 kinase
  613. p70s6k Integrates Phosphatidylinositol 3โ€“kinase and Rapamycin-Regulated Signals for E2F Regulation in T Lymphocytes
  614. Inhibition of Phosphatidylinositol 3โ€“kinase activity by adenovirus-mediated gene transfer and its effect on insulin action
  615. โ€ฆ -permeable AMPA receptors induce phosphorylation of cAMP response element-binding protein through a Phosphatidylinositol 3โ€“kinase-dependent stimulation of the โ€ฆ
  616. Insulin stimulation of the fatty acid synthase promoter is mediated by the Phosphatidylinositol 3โ€“kinase pathway: involvement of protein kinase B/Akt
  617. Phosphatidylinositol 3โ€“kinase ฮณ mediates shear stress-dependent activation of JNK in endothelial cells
  618. Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not Phosphatidylinositol 3โ€“kinase in rat skeletal muscle.
  619. ฮฑPIX nucleotide exchange factor is activated by interaction with Phosphatidylinositol 3โ€“kinase
  620. Insulin receptor substrate-1 phosphorylation and Phosphatidylinositol 3โ€“kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation
  621. Dedifferentiation of adenocarcinomas by activation of Phosphatidylinositol 3โ€“kinase
  622. Role of Phosphatidylinositol 3โ€“kinase activation in the hypertrophic growth of adult ventricular cardiomyocytes
  623. A redox-triggered ras-effector interaction: recruitment of Phosphatidylinositol 3โ€ฒ-kinase to Ras by redox stress
  624. Intermolecular interactions of the p85ฮฑ regulatory subunit of Phosphatidylinositol 3โ€“kinase
  625. Vac1p coordinates Rab and Phosphatidylinositol 3โ€“kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosome
  626. Requirement of Phosphatidylinositolโ€“3 kinase for activation of JNK/SAPKs by PDGF
  627. 1ฮฑ,25-Dihydroxyvitamin D3โ€“Induced Myeloid Cell Differentiation Is Regulated by a Vitamin D Receptorโ€“Phosphatidylinositol 3โ€“kinase Signaling Complex
  628. Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and Phosphatidylinositol 3โ€“kinase in 3T3-L1 adipocytes: a โ€ฆ
  629. โ€ฆ rescue cerebellar granule neurons from oxidative stressโ€mediated apoptotic death: selective involvement of Phosphatidylinositol 3โ€kinase and the mitogenโ€activated โ€ฆ
  630. Phosphatidylinositol 3โ€“kinase activation is required for insulin-stimulated sodium transport in A6 cells
  631. Requirement of Phosphatidylinositol 3โ€“kinase-dependent pathway and Src for Gas6-Axl mitogenic and survival activities in NIH 3T3 fibroblasts
  632. The p85 subunit of Phosphatidylinositol 3โ€“kinase associates with the Fc receptor ฮณ-chain and linker for activitor of T cells (LAT) in platelets stimulated by โ€ฆ
  633. Phosphatidylinositol 3โ€“kinase-dependent activation of protein kinase C-ฮถ in bacterial lipopolysaccharide-treated human monocytes
  634. Expression of a constitutively active Phosphatidylinositol 3โ€“kinase induces process formation in rat PC12 cells: use of Cre/loxP recombination system
  635. Inhibition of Phosphatidylinositol 3โ€“kinase induces nitric-oxide synthase in lipopolysaccharide-or cytokine-stimulated C6 glial cells
  636. Receptors of the glial cell line-derived neurotrophic factor family of neurotrophic factors signal cell survival through the Phosphatidylinositol 3โ€“kinase pathway in spinal โ€ฆ
  637. AKT2, a Member of the Protein kinase B Family, Is Activated by Growth Factors, v-Ha-ras, and v-src through Phosphatidylinositol 3โ€“kinase in Human Ovarian โ€ฆ
  638. Activation of protein kinase C-ฮถ and Phosphatidylinositol 3โ€ฒ-kinase and promotion of macrophage differentiation by insulin-like growth factor-I
  639. Phosphatidylinositol 3โ€“kinase contributes to Erk1/Erk2 MAP kinase activation associated with hepatocyte growth factor-induced cell scattering
  640. Downstream of Phosphatidylinositolโ€“3 kinase, a multifunctional signaling molecule, and its regulation in cell responses
  641. Human dopamine D3 receptors mediate mitogen-activated protein kinase activation via a Phosphatidylinositol 3โ€“kinase and an atypical protein kinase C-dependent โ€ฆ
  642. Phosphatidylinositolโ€3 kinase is involved in ruffled border formation in osteoclasts
  643. Membrane-targeted Phosphatidylinositol 3โ€“kinase mimics insulin actions and induces a state of cellular insulin resistance
  644. A function for Phosphatidylinositol 3โ€“kinase ฮฒ (p85ฮฑ-p110ฮฒ) in fibroblasts during mitogenesis: requirement for insulin-and lysophosphatidic acid-mediated signal โ€ฆ
  645. Phosphatidylinositol 3โ€kinase and Akt protein kinase mediate IGFโ€Iโ€and prosaptideโ€induced survival in Schwann cells
  646. Activation of Phosphatidylinositol 3โ€kinase, but not extracellularโ€regulated kinases, is necessary to mediate brainโ€derived neurotrophic factorโ€induced motoneuron โ€ฆ
  647. Phosphatidylinositol 3โ€“kinase contributes to cell volume regulation through effects on ATP release
  648. Phosphatidylinositol 3โ€“kinase is required for the formation of constitutive transport vesicles from the TGN
  649. Enhanced Phosphatidylinositol 3โ€“kinase activity and high phosphorylation state of its downstream signalling molecules mediated by ret with the MEN 2B mutation
  650. A collagen-related peptide regulates phospholipase Cฮณ2 via Phosphatidylinositol 3โ€“kinase in human platelets
  651. Phosphatidylinositol 3โ€kinase: increased activity and protein level in amyotrophic lateral sclerosis
  652. Enhanced insulin-stimulated activation of Phosphatidylinositol 3โ€“kinase in the liver of high-fat-fed rats.
  653. SHP-1 regulates Lck-induced Phosphatidylinositol 3โ€“kinase phosphorylation and activity
  654. Insulin-like growth factors require Phosphatidylinositol 3โ€“kinase to signal myogenesis: dominant negative p85 expression blocks differentiation of L6E9 muscle cells
  655. DHEA improves glucose uptake via activations of protein kinase C and Phosphatidylinositol 3โ€“kinase
  656. Insulin-like growth factor-II, Phosphatidylinositol 3โ€“kinase, nuclear factor-ฮบB and inducible nitric-oxide synthase define a common myogenic signaling pathway
  657. Phosphorylation of CD19 Y484 and Y515, and linked activation of Phosphatidylinositol 3โ€“kinase, are required for B cell antigen receptor-mediated activation of โ€ฆ
  658. The B cell antigen receptor activates the Akt (protein kinase B)/glycogen synthase kinaseโ€“3 signaling pathway via Phosphatidylinositol 3โ€“kinase
  659. Endosomal recycling of the Na+/H+ exchanger NHE3 isoform is regulated by the Phosphatidylinositol 3โ€“kinase pathway
  660. Differential effects of constitutively active Phosphatidylinositol 3โ€“kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes
  661. Interleukin-6 inhibits transforming growth factor-ฮฒ-induced apoptosis through the Phosphatidylinositol 3โ€“kinase/Akt and signal transducers and activators of โ€ฆ
  662. โ€ฆ in response to dexamethasone is associated with inhibition of insulin-like growth factor-I stimulated Phosphatidylinositol 3โ€“kinase activity in cultured muscle โ€ฆ
  663. Requirement for Phosphatidylinositolโ€“3โ€ฒ-kinase in cytokine-mediated germ cell survival during fetal oogenesis in the mouse
  664. Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for Phosphatidylinositol 3โ€“kinase in adipocytes from subjects with non-insulin โ€ฆ
  665. Defective regulation of Phosphatidylinositolโ€“3โ€“kinase gene expression in skeletal muscle and adipose tissue of non-insulin-dependent diabetes mellitus patients
  666. โ€ฆ transporter mRNAs in response to insulin: role of mammalian target of rapamycin, protein kinase b, and Phosphatidylinositol 3โ€“kinase in GLUT1 mRNA โ€ฆ
  667. Grb2-associated binder-1 mediates Phosphatidylinositol 3โ€“kinase activation and the promotion of cell survival by nerve growth factor
  668. Phosphorylationโ€“dependent interaction of the Nโ€methylโ€ dโ€aspartate receptor ฮต2 subunit with Phosphatidylinositol 3โ€kinase
  669. Differential regulation of insulin receptor substrates-1 and-2 (IRS-1 and IRS-2) and Phosphatidylinositol 3โ€“kinase isoforms in liver and muscle of the obese diabetic (ob โ€ฆ
  670. Phosphatidylinositol 3โ€“kinase-mediated Endocytosis of Renal Na+,K+-ATPase ฮฑ Subunit in Response to Dopamine
  671. Involvement of Phosphatidylinositol 3โ€“kinase in stromal cell-derived factor-1ฮฑ-induced lymphocyte polarization and chemotaxis
  672. Protein kinase B (c-Akt), Phosphatidylinositol 3โ€“kinase, and STAT5 are activated by erythropoietin (EPO) in HCD57 erythroid cells but are constitutively active in an โ€ฆ
  673. Hepatocyte growth factor promotes migration of human hepatocellular carcinoma via Phosphatidylinositol 3โ€“kinase
  674. Inhibition of Phosphatidylinositolโ€“3โ€“kinase blocks development of functional embryonic cardiomyocytes
  675. โ€ฆ prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1,-2, and-3, their association with p85 Phosphatidylinositol 3โ€“kinase (PI3โ€“kinase), and โ€ฆ
  676. Roles of Phosphatidylinositol 3โ€“kinase and mitogen-activated protein kinase pathways in stimulation of vascular smooth muscle cell migration and deoxyriboncleic โ€ฆ
  677. TGF-ฮฒ1 modulates EGF-stimulated Phosphatidylinositol 3โ€“kinase activity in human airway smooth muscle cells
  678. Phosphatidylinositol 3โ€“kinase is involved in the protection of primary cultured human erythroid precursor cells from apoptosis
  679. Phosphatidylinositol 3โ€“kinase is a target for protein tyrosine nitration
  680. Phosphatidylinositolโ€“3 kinase is necessary for 12-O-tetradecanoylphorbol-13-acetate-induced cell transformation and activated protein 1 activation
  681. p21 ras and Phosphatidylinositolโ€“3 kinase are required for survival of wild-type and NF1 mutant sensory neurons
  682. Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/Phosphatidylinositol 3โ€“kinase pathway
  683. โ€ฆ -activated protein kinase activation through Fcฮต receptor I and stem cell factor receptor is differentially regulated by Phosphatidylinositol 3โ€“kinase and calcineurin in โ€ฆ
  684. Microinjection of activated Phosphatidylinositolโ€“3 kinase induces process outgrowth in rat PC12 cells through the Rac-JNK signal transduction pathway
  685. Prolactin induced tyrosine phosphorylation of p59fyn may mediate Phosphatidylinositol 3โ€“kinase activation in Nb2 cells.
  686. Glucagon-like peptide-1 promotes DNA synthesis, activates Phosphatidylinositol 3โ€“kinase and increases transcription factor pancreatic and duodenal homeobox gene โ€ฆ
  687. Phosphatidylinositol 3โ€“kinase is involved in the induction of macrophage growth by oxidized low density lipoprotein
  688. Phosphatidylinositol 3โ€“kinase Requirement in Activation of the ras/C-raf-1/MEK/ERK and p70s6k Signaling Cascade by the Insulinomimetic Agent Vanadyl Sulfate
  689. Ataxiaโ€telangiectasia without immunodeficiency: Novel point mutations within and adjacent to the Phosphatidylinositol 3โ€kinaseโ€like domain
  690. Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-Kit, Phosphatidylinositol 3โ€“kinase, and p120CBL
  691. Modification of Phosphatidylinositol 3โ€“kinase SH2 domain binding properties by Abl-or Lck-mediated tyrosine phosphorylation at Tyr-688
  692. Identification of a common amino acid polymorphism in the p85ฮฑ regulatory subunit of Phosphatidylinositol 3โ€“kinase: effects on glucose disappearance constant โ€ฆ
  693. Regionโ€specific mRNA expression of Phosphatidylinositol 3โ€kinase regulatory isoforms in the central nervous system of C57BL/6J mice
  694. Heat shock activates c-Src tyrosine kinases and Phosphatidylinositol 3โ€“kinase in NIH3T3 fibroblasts
  695. Evidence of a role for Phosphatidylinositol 3โ€“kinase activation in the blocking of apoptosis by polyomavirus middle T antigen
  696. Comparative Effects of GTPฮณS and Insulin on the Activation of Rho, Phosphatidylinositol 3โ€“kinase, and Protein kinase N in Rat Adipocytes: RELATIONSHIP โ€ฆ
  697. Nerve growth factor protects PC12 cells against peroxynitriteโ€induced apoptosis via a mechanism dependent on Phosphatidylinositol 3โ€kinase
  698. Activation of Phosphatidylinositol 3โ€“kinase, protein kinase B, and p70 S6 kinases in lipopolysaccharide-stimulated Raw 264.7 cells: differential effects of rapamycin โ€ฆ
  699. Phosphatidylinositol 3โ€“kinase association with the osteoclast cytoskeleton, and its involvement in osteoclast attachment and spreading
  700. โ€ฆ of the ADP-ribosylation factor-exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of Phosphatidylinositol 3โ€“kinase and the GRP1 โ€ฆ
  701. Thymocyte activation induces the association of Phosphatidylinositol 3โ€kinase and pp120 with CD5
  702. Heregulin ฮฒ1-activated Phosphatidylinositol 3โ€“kinase enhances aggregation of MCF-7 breast cancer cells independent of extracellular signal-regulated kinase
  703. Phosphatidylinositol 3โ€“kinase Is Required for Growth Factorโ€“Induced Amino Acid Uptake by Vascular Smooth Muscle Cells
  704. The proto-oncogene product p120cbl links c-Src and Phosphatidylinositol 3โ€ฒ-kinase to the integrin signaling pathway
  705. CD28 receptor endocytosis is targeted by mutations that disrupt Phosphatidylinositol 3โ€“kinase binding and costimulation
  706. Protein kinase B/Akt is activated by polyomavirus middle-T antigen via a Phosphatidylinositol 3โ€“kinase-dependent mechanism
  707. Assessment of the roles of mitogen-activated protein kinase, Phosphatidylinositol 3โ€“kinase, protein kinase B, and protein kinase C in insulin inhibition of cAMP โ€ฆ
  708. Thrombopoietin induces activation of the Phosphatidylinositolโ€3โ€ฒ kinase pathway and formation of a complex containing p85PI3K and the protooncoprotein p120CBL
  709. Signaling through CD5 activates a pathway involving Phosphatidylinositol 3โ€“kinase, Vav, and Rac1 in human mature T lymphocytes
  710. Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with Phosphatidylinositol 3โ€“kinase
  711. Erythropoietin induces the tyrosine phosphorylation of GAB1 and its association with SHC, SHP2, SHIP, and Phosphatidylinositol 3โ€“kinase
  712. Epidermal growth factor modulates tyrosine phosphorylation of p130Cas: involvement of Phosphatidylinositol 3โ€ฒ-kinase and actin cytoskeleton
  713. Phosphatidylinositol 3โ€ฒ-kinase and SH2-containing inositol phosphatase (SHIP) are recruited by distinct positive and negative growth-regulatory domains in the โ€ฆ
  714. Selective up-regulation of Phosphatidylinositol 3โ€ฒ-kinase activity in Th2 cells inhibits caspase-8 cleavage at the death-inducing complex: a mechanism for Th2 โ€ฆ
  715. Inhibition of Phosphatidylinositol 3โ€“kinase activity elevates c-Jun N-terminal kinase activity in apoptosis of cultured cerebellar granule neurons
  716. Vanadyl sulfate-stimulated glycogen synthesis is associated with activation of Phosphatidylinositol 3โ€“kinase and is independent of insulin receptor tyrosine โ€ฆ
  717. Phosphatidylinositol 3โ€“kinase-dependent and-independent cytolytic effector functions
  718. Activation of Phosphatidylinositol 3โ€“kinase by interleukin-13: an inhibitory signal for inducible nitric-oxide synthase expression in epithelial cell line HT-29
  719. G1 phase arrest by the Phosphatidylinositol 3โ€“kinase inhibitor LY 294002 is correlated to up-regulation of p27Kip1 and inhibition of G1 CDKs in choroidal โ€ฆ
  720. Phosphatidylinositol 3โ€ฒ-kinase-independent p70 S6 kinase activation by fibroblast growth factor receptor-1 is important for proliferation but not differentiation โ€ฆ
  721. โ€ฆ Tyrosine Phosphorylation of p130Cas, Focal Adhesion kinase, and Paxillin: ROLE OF Phosphatidylinositol 3โ€ฒ-kinase AND FORMATION OF A โ€ฆ
  722. Gastrin stimulates the formation of a p60Src/p125FAK complex upstream of the Phosphatidylinositol 3โ€“kinase signaling pathway
  723. A Phosphatidylinositol 3โ€“kinase inhibitor induces a senescent-like growth arrest in human diploid fibroblasts
  724. A Phosphatidylinositol 3โ€“kinase and Phosphatidylinositol transfer protein act synergistically in formation of constitutive transport vesicles from the trans-Golgi โ€ฆ
  725. Insulin-like growth factor (IGF)-I regulates IGF-binding protein-5 gene expression through the Phosphatidylinositol 3โ€“kinase, protein kinase B/Akt, and p70 S6 โ€ฆ
  726. ฮฑ-Adrenergic stimulation mediates glucose uptake through Phosphatidylinositol 3โ€“kinase in rat heart
  727. A Phosphatidylinositol 3โ€kinase inhibitor wortmannin induces radioresistant DNA synthesis and sensitizes cells to bleomycin and ionizing radiation
  728. Intracellular movement of green fluorescent proteinโ€“tagged Phosphatidylinositol 3โ€“kinase in response to growth factor receptor signaling
  729. Activation and translocation of Rho (and ADP ribosylation factor) by insulin in rat adipocytes: apparent involvement of Phosphatidylinositol 3โ€“kinase
  730. Intermediate affinity interleukin-2 receptor mediates survival via a Phosphatidylinositol 3โ€“kinase-dependent pathway
  731. The Phosphatidylinositol 3โ€“kinase inhibitor wortmannin markedly reduces chemotactic peptide-induced locomotion and increases in cytoskeletal actin in human โ€ฆ
  732. โ€ฆ pervanadate, stimulate glucose transport and GLUT translocation in muscle cells by a mechanism independent of Phosphatidylinositol 3โ€“kinase and protein kinase C.
  733. The Phosphatidylinositol 3โ€kinase inhibitor wortmannin alters the metabolism of the Alzheimerโ€™s amyloid precursor protein
  734. โ€ฆ tyrosine kinase inhibits inducible nitric oxide synthase (iNOS) expression by murine peritoneal exudate macrophages: Phosphatidylinositolโ€“3 kinase is required for โ€ฆ
  735. Involvement of Phosphatidylinositol 3โ€“kinase in NFAT activation in T cells
  736. Endothelin-1 modulates insulin signaling through Phosphatidylinositol 3โ€“kinase pathway in vascular smooth muscle cells.
  737. Phosphatidylinositol 3โ€“kinase in HL-60 nuclei is bound to the nuclear matrix and increases during granulocytic differentiation
  738. Multiple isoforms of the regulatory subunit for Phosphatidylinositol 3โ€“kinase (PI3โ€“kinase) are expressed in neurons in the rat brain
  739. The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 Phosphatidylinositol 3โ€“kinase and the class II PI3K-C2ฮฑ
  740. The p85 and p110 subunits of Phosphatidylinositol 3โ€“kinase-ฮฑ are substrates, in vitro, for a constitutively associated protein tyrosine kinase in platelets
  741. Phosphatidylinositol 3โ€“kinase translocation to the nucleus is induced by interleukin 1 and prevented by mutation of interleukin 1 receptor in human osteosarcoma โ€ฆ
  742. The epidermal growth factor receptor associates with and recruits Phosphatidylinositol 3โ€“kinase to the platelet-derived growth factor ฮฒ receptor
  743. The Phosphatidylinositol 3โ€ฒ kinase pathway is required for the survival signal of leukocyte tyrosine kinase
  744. Phosphatidylinositol 3โ€“kinase is a requirement for insulin-like growth factor I-induced differentiation, but not for mitogenesis, in fetal brown adipocytes
  745. Stimulation of IRS-1-associated Phosphatidylinositol 3โ€“kinase and Akt/protein kinase B but not glucose transport by ฮฒ1-integrin signaling in rat adipocytes
  746. โ€ฆ colony-stimulating factor-activated signaling pathways in human neutrophils: involvement of Jak2 in the stimulation of Phosphatidylinositol 3โ€“kinase
  747. CD38 ligation in human B cell progenitors triggers tyrosine phosphorylation of CD19 and association of CD19 with lyn and Phosphatidylinositol 3โ€“kinase.
  748. MAP kinase activation by mu opioid receptor involves Phosphatidylinositol 3โ€“kinase but not the cAMP/PKA pathway
  749. Platelet-derived growth factor-dependent cellular transformation requires either phospholipase Cฮณ or Phosphatidylinositol 3 kinase
  750. Sublytic C5b-9 induces proliferation of human aortic smooth muscle cells: role of mitogen activated protein kinase and Phosphatidylinositol 3โ€“kinase
  751. โ€ฆ novel pathway for tumor necrosis factor-ฮฑ and ceramide signaling involving sequential activation of tyrosine kinase, p21ras, and Phosphatidylinositol 3โ€“kinase
  752. Synergistic roles of neuregulin-1 and insulin-like growth factor-I in activation of the Phosphatidylinositol 3โ€“kinase pathway and cardiac chamber โ€ฆ
  753. Calmodulin is involved in membrane depolarization-mediated survival of motoneurons by Phosphatidylinositolโ€“3 kinase-and MAPK-independent pathways
  754. p70 S6 kinase is activated by sodium arsenite in adult rat cardiomyocytes: roles for Phosphatidylinositol 3โ€“kinase and p38 MAP kinase
  755. Phosphatidylinositol 3โ€“kinase and Ca2+ influx dependence for ligand-stimulated internalization of the c-Kit receptor
  756. Epidermal growth factor receptor-regulated human bladder cancer motility is in part a Phosphatidylinositol 3โ€“kinase-mediated process
  757. Involvement of Phosphatidylinositolโ€“3 kinase in prevention of low K+-induced apoptosis of cerebellar granule neurons
  758. PTEN modulates cell cycle progression and cell survival by regulating Phosphatidylinositol 3, 4, 5,-trisphosphate and Akt/protein kinase B signaling pathway
  759. โ€ฆ lipopolysaccharide stimulate extracellularly regulated kinase activation in macrophages by a mechanism involving Phosphatidylinositol 3โ€“kinase and phospholipase D โ€ฆ
  760. CD28 can promote T cell survival through a Phosphatidylinositol 3โ€kinaseโ€independent mechanism
  761. SIP/SHIP inhibits Xenopus oocyte maturation induced by insulin and Phosphatidylinositol 3โ€“kinase
  762. Insulin regulation of glucose-6-phosphate dehydrogenase gene expression is rapamycin-sensitive and requires Phosphatidylinositol 3โ€“kinase
  763. Lysophosphatidylcholine generates superoxide anions through activation of Phosphatidylinositol 3โ€“kinase in human neutrophils
  764. Insulin receptor substrate (IRS)-2 is dephosphorylated more rapidly than IRS-1 via its association with Phosphatidylinositol 3โ€“kinase in skeletal muscle cells
  765. The survival of sympathetic neurons promoted by potassium depolarization, but not by cyclic AMP, requires Phosphatidylinositol 3โ€kinase and Akt
  766. Nuclear translocation of PKCฮถ during ischemia and its inhibition by wortmannin, an inhibitor of Phosphatidylinositol 3โ€“kinase
  767. CD7-mediated regulation of integrin adhesiveness on human T cells involves tyrosine phosphorylation-dependent activation of Phosphatidylinositol 3โ€“kinase.
  768. LCK-phosphorylated human killer cell-inhibitory receptors recruit and activate Phosphatidylinositol 3โ€“kinase
  769. 14-3โ€“3ฮฒ protein associates with insulin receptor substrate 1 and decreases insulin-stimulated Phosphatidylinositol 3โ€ฒ-kinase activity in 3T3L1 adipocytes
  770. Evidence that Phosphatidylinositol 3โ€“kinase and p70S6K protein are involved in differentiation of HL-60 cells induced by calcitriol.
  771. Inhibition of Phosphatidylinositol 3โ€kinase activity blocks cellular differentiation mediated by glial cell lineโ€derived neurotrophic factor in dopaminergic neurons
  772. Roles of Phosphatidylinositol 3โ€“kinase and Rac in the nuclear signaling by tumor necrosis factor-ฮฑ in rat-2 fibroblasts
  773. Inositol hexaphosphate inhibits cell transformation and activator protein 1 activation by targeting Phosphatidylinositolโ€“3โ€ฒ kinase
  774. The role of Phosphatidylinositol 3โ€“kinase, Src kinase, and protein kinase A signaling pathways in insulin and glucagon regulation of CYP2E1 expression
  775. Mitogen-activated protein kinase and Phosphatidylinositol 3โ€“kinase pathways are not sufficient for insulin-like growth factor I-induced mitogenesis and tumorigenesis
  776. Fc receptor-mediated platelet activation is dependent on Phosphatidylinositol 3โ€“kinase activation and involves p120cbl
  777. Variant in the regulatory subunit of Phosphatidylinositol 3โ€“kinase (p85alpha): preliminary evidence indicates a potential role of this variant in the acute insulin โ€ฆ
  778. โ€ฆ 3โ€“kinase/p70 ribosomal S6 protein kinase pathway is required for the regulation by insulin of the p85ฮฑ regulatory subunit of Phosphatidylinositol 3โ€“kinase โ€ฆ
  779. The involvement of Phosphatidylinositol 3โ€“kinase in crystal induced human neutrophil activation.
  780. Wortmannin inhibits the growth of mammary tumors despite the existence of a novel wortmannin-insensitive Phosphatidylinositolโ€“3โ€“kinase
  781. โ€ฆ receptors gives rise to the selective modulation of intracellular signaling in B cells: regulation of the association of Phosphatidylinositol 3โ€“kinase and inositol 5 โ€ฆ
  782. Phosphatidylinositol 3โ€ฒ-kinase and tyrosine-phosphatase activation positively modulate Convulxin-induced platelet activation. Comparison with collagen
  783. Phosphorylation of cbl after Stimulation of Nb2 Cells with Prolactin and Its Association with Phosphatidylinositol 3โ€“kinase
  784. Phosphatidylinositol 3โ€“kinase translocates onto liver endoplasmic reticulum and may account for the inhibition of glucose-6-phosphatase during refeeding
  785. Regulation of endocytic-transcytotic pathways and bile secretion by Phosphatidylinositol 3โ€“kinase in rats
  786. Cripto-1 induces Phosphatidylinositol 3โ€ฒ-kinase-dependent phosphorylation of AKT and glycogen synthase kinase 3ฮฒ in human cervical carcinoma cells
  787. Epidermal growth factor stimulation of Phosphatidylinositol 3โ€“kinase during wound closure in rabbit corneal epithelial cells.
  788. โ€ฆ induces the tyrosine phosphorylation of insulin receptor substrate-2: an alternate pathway for erythropoietin-induced Phosphatidylinositol 3โ€“kinase activation
  789. Localization of a class II Phosphatidylinositol 3โ€“kinase, PI3KC2ฮฑ, to clathrin-coated vesicles
  790. Role of the vav proto-oncogene product (Vav) in erythropoietin-mediated cell proliferation and Phosphatidylinositol 3โ€“kinase activity
  791. Possible involvement of Phosphatidylinositol 3โ€kinase in regulated exocytosis: studies in chromaffin cells with inhibitor LY294002
  792. Src-family Tyrosine kinases in Activation of ERK-1 and p85/p110-Phosphatidylinositol 3โ€“kinase by G/CCKBReceptors
  793. Signaling through the EBV/C3d receptor (CR2, CD21) in human B lymphocytes: activation of Phosphatidylinositol 3โ€“kinase via a CD19-independent pathway
  794. Cloning of human p55ฮณ, a regulatory subunit of Phosphatidylinositol 3โ€“kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor
  795. Angiotensin II induces activation of Phosphatidylinositol 3โ€“kinase in cardiomyocytes
  796. Involvement of Phosphatidylinositol 3โ€ฒโ€kinase in stemโ€cellโ€factorโ€induced phospholipase D activation and arachidonic acid release
  797. CD45-induced tumor necrosis factor ฮฑ production in monocytes is Phosphatidylinositol 3โ€“kinase-dependent and nuclear factor-ฮบB-independent
  798. Wortmannin, a Phosphatidylinositol 3โ€“kinase inhibitor, blocks antigen-mediated, but not CD3 monoclonal antibody-induced, activation of murine CD4+ T cells.
  799. Phosphatidylinositol 3โ€“kinase is required for CD28 but not CD3 regulation of the TEC family tyrosine kinase EMT/ITK/TSK: functional and physical interaction of EMT โ€ฆ
  800. Endothelin-1-induced GLUT4 translocation is mediated via Gฮฑq/11 protein and Phosphatidylinositol 3โ€“kinase in 3T3-L1 adipocytes
  801. N-Methyl-D-aspartate inhibits apoptosis through activation of Phosphatidylinositol 3โ€“kinase in cerebellar granule neurons: a role for insulin receptor substrate โ€ฆ
  802. Phosphatidylinositol 3โ€kinase binds to profilin through the p85ฮฑ subunit and regulates cytoskeletal assembly
  803. HMG-CoA reductase inhibitor-induced L6 myoblast cell death: involvement of the Phosphatidylinositol 3โ€“kinase pathway
  804. Requirement for Ras and Phosphatidylinositol 3โ€“kinase signaling uncouples the glucocorticoid-induced junctional organization and transepithelial electrical โ€ฆ
  805. Cell Interactions with Collagen Matrices In Vivo and In Vitro Depend on Phosphatidylinositol 3โ€“kinase and Free Cytoplasmic Calcium
  806. Affinity modulation of very late antigen-5 through Phosphatidylinositol 3โ€“kinase in mast cells
  807. Tyrosine phosphorylation of the CD3-ฮต subunit of the T cell antigen receptor mediates enhanced association with Phosphatidylinositol 3โ€“kinase in Jurkat T โ€ฆ
  808. Platelet-derived growth factor inhibits insulin stimulation of insulin receptor substrate-1-associated Phosphatidylinositol 3โ€“kinase in 3T3-L1 adipocytes without โ€ฆ
  809. โ€ฆ choline phosphate-induced mitogenesis in fibroblasts involves activation of pp70 S6 kinase and Phosphatidylinositol 3โ€ฒ-kinase through an extracellular site โ€ฆ
  810. Functional cooperation of the interleukin-2 receptor ฮฒ chain and Jak1 in Phosphatidylinositol 3โ€“kinase recruitment and phosphorylation
  811. โ€ฆ Factorโ€“Activated Signaling Pathways in Human Neutrophils. I. Tyrosine Phosphorylation-Dependent Stimulation of Phosphatidylinositol 3โ€“kinase and Inhibition by โ€ฆ
  812. Insulin receptor substrate-1 and Phosphatidylinositol 3โ€“kinase regulate extracellular signal-regulated kinase-dependent and-independent signaling pathways during โ€ฆ
  813. Binding of receptor-recognized forms of ฮฑ2-macroglobulin to the ฮฑ2-macroglobulin signaling receptor activates Phosphatidylinositol 3โ€“kinase
  814. โ€ฆ HT-29 cells is independent of nitric oxide formation: evidence for an interleukin-13-driven Phosphatidylinositol 3โ€“kinase-dependent survival mechanism
  815. Involvement of protein tyrosine kinase p72syk and Phosphatidylinositol 3โ€“kinase in CD2-mediated granular exocytosis in the natural killer cell line, NK3. 3.
  816. Expression of Phosphatidylinositol 3โ€“kinase during EGF-Stimulated Wound Repair in Rabbit Corneal Epithelium
  817. Insulin-like growth factor-1 stimulates rat prolactin gene expression by a Ras, ETS and Phosphatidylinositol 3โ€“kinase dependent mechanism
  818. SHP-1 associates with both platelet-derived growth factor receptor and the p85 subunit of Phosphatidylinositol 3โ€“kinase
  819. CD72โ€mediated B cell activation involves recruitment of CD19 and activation of Phosphatidylinositol 3โ€kinase
  820. Action of insulin on the surface morphology of hepatocytes: role of Phosphatidylinositol 3โ€“kinase in insulin-induced shape change of microvilli
  821. Biphasic activation of p21ras by endothelin-1 sequentially activates the ERK cascade and Phosphatidylinositol 3โ€“kinase
  822. โ€ฆ factor of src-and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells: Phosphatidylinositol 3โ€ฒ-kinase is a critical โ€ฆ
  823. Identification and chromosome assignment of a human gene encoding a novel Phosphatidylinositolโ€“3 kinase
  824. Phosphatidylinositol 3โ€ฒ-kinase, but not S6-kinase, is required for insulin-like growth factor-I and IL-4 to maintain expression of Bcl-2 and promote survival of myeloid โ€ฆ
  825. Epidermal growth factor and insulin-induced deoxyribonucleic acid synthesis in primary rat hepatocytes is Phosphatidylinositol 3โ€“kinase dependent and dissociated โ€ฆ
  826. โ€ฆ (p125FAK) and paxillin in rat pancreatic acini by a phospholipase C-independent process that depends on Phosphatidylinositol 3โ€“kinase, the small GTP โ€ฆ
  827. Effects of Phosphatidylinositolโ€“3โ€“kinase inhibitors on degranulation and gene induction in allergically triggered mouse mast cells
  828. Activation of Phosphatidylinositol 3โ€˜-kinase by insulin-like growth factor-I rescues promyeloid cells from apoptosis and permits their differentiation into granulocytes.
  829. Epidermal growth factor stimulates phospholipase D independent of phospholipase C, protein kinase C or Phosphatidylinositolโ€“3 kinase activation in immortalized โ€ฆ
  830. โ€ฆ diphosphotyrosine-containing peptide that mimics activated platelet-derived growth factor receptor ฮฒ induces oligomerization of Phosphatidylinositol 3โ€“kinase
  831. Monocytic differentiation of HL-60 cells is characterized by the nuclear translocation of Phosphatidylinositol 3โ€“kinase and of definite Phosphatidylinositol-specific โ€ฆ
  832. Thapsigargin-induced secretion is dependent on activation of a cholera toxin-sensitive and Phosphatidylinositolโ€“3โ€“kinase-regulated phospholipase D in a mast cell โ€ฆ
  833. Changes in the mitogen-activated protein kinase and Phosphatidylinositol 3โ€“kinase/Akt signaling associated with the induction of apoptosis.
  834. IL-2 signaling controls actin organization through Rho-like protein family, Phosphatidylinositol 3โ€“kinase, and protein kinase C-zeta.
  835. A role for Phosphatidylinositol 3โ€“kinase in platelet aggregation in response to low, but not high, concentrations of PAF or thrombin
  836. Differential association of Phosphatidylinositol 3โ€“kinase with insulin receptor substrate (IRS)-1 and IRS-2 in human thymocytes in response to IL-7.
  837. Effect of wortmannin, an inhibitor of Phosphatidylinositol 3โ€“kinase, on the first mitotic divisions of the fertilized sea urchin egg
  838. Plateletโ€Derived Growth Factor Stimulates Sodiumโ€Dependent Pi Transport in Osteoblastic Cells via Phospholipase Cฮณ and Phosphatidylinositol 3โ€ฒโ€kinase
  839. Inhibition of human cardiac fibroblast mitogenesis by blockade of mitogenโ€activated protein kinase and Phosphatidylinositol 3โ€kinase
  840. Phosphatidylinositol 3โ€“kinase and dynamics of insulin resistance in denervated slow and fast muscles in vivo
  841. Phosphatidylinositol 4-kinase, but not Phosphatidylinositol 3โ€“kinase, is present in GLUT4-containing vesicles isolated from rat skeletal muscle
  842. Raf-1 kinase Activation by Angiotensin II in Adrenal Glomerulosa Cells: Roles of Gi, Phosphatidylinositol 3โ€“kinase, and Ca2+ Influx
  843. The inositol polyphosphate 4-phosphatase forms a complex with Phosphatidylinositol 3โ€“kinase in human platelet cytosol
  844. โ€ฆ chemokinesis in normal human neutrophils is dependent on Dโ€glucose concentration and sensitive to inhibitors of tyrosine kinase and Phosphatidylinositol 3โ€kinase
  845. Brainโ€derived neurotrophic factor stimulates interactions of Shp2 with Phosphatidylinositol 3โ€kinase and Grb2 in cultured cerebral cortical neurons
  846. Phosphatidylinositol 3โ€“kinase and focal adhesion kinase are early signals in the growth factorโ€“like responses to thrombospondin-1 seen in human vascular smooth โ€ฆ
  847. Insulin stimulation of K+ uptake in 3T3-L1 fibroblasts involves Phosphatidylinositol 3โ€“kinase and protein kinase C-zeta
  848. Phosphatidylinositol 3โ€ฒ-kinase and p70s6k are required for insulin but not bisperoxovanadium 1, 10-phenanthroline (bpV (phen)) inhibition of insulin-like โ€ฆ
  849. โ€ฆ secretagogues activate protein tyrosine phosphorylation and release of arachidonic acid in mast cells via a novel protein kinase C and Phosphatidylinositol 3โ€kinase โ€ฆ
  850. Possible role for Phosphatidylinositol 3โ€“kinase in regulating meiotic maturation of bovine oocytes in vitro
  851. Insulin receptor substrate (IRS)-1 and IRS-2 are tyrosine-phosphorylated and associated with Phosphatidylinositol 3โ€“kinase in response to brain-derived โ€ฆ
  852. โ€ฆ C-ฮณ1 renders platelet-derived growth factor ฮฒ-receptor-expressing cells independent of the Phosphatidylinositol 3โ€“kinase pathway for chemotaxis
  853. Activation of Phosphatidylinositol 3โ€“kinase is necessary for differentiation of FDC-P1 cells following stimulation of type III receptor tyrosine kinases
  854. Potentiation of Insulin-Induced Phosphatidylinositolโ€“3 kinase Activity by Phorbol Ester Is Mediated by Protein kinase Cฯต
  855. Phosphatidylinositol 3โ€“kinase and protein kinase C are required for the inhibition of caspase activity by epidermal growth factor
  856. Signalling-competent truncated forms of ErbB2 in breast cancer cells: differential regulation by protein kinase C and Phosphatidylinositol 3โ€“kinase
  857. Involvement of both the tyrosine kinase and the Phosphatidylinositolโ€“3โ€ฒ kinase signal transduction pathways in the regulation of lipoprotein lipase expression in J774 โ€ฆ
  858. Role of Phosphatidylinositol 3โ€“kinase in degranulation induced by IgE-dependent and-independent mechanisms in rat basophilic RBL-2H3 (ml) cells
  859. PDGF-induced glycosaminoglycan synthesis is mediated via Phosphatidylinositol 3โ€“kinase
  860. โ€ฆ new tyrosine-phosphorylated 97-kDa adaptor protein mediates interleukin-2-induced association of SHP-2 with p85-Phosphatidylinositol 3โ€“kinase in human T โ€ฆ
  861. Phosphatidylinositol 3โ€“kinase mediates heregulin-induced growth inhibition in human epithelial cells.
  862. Insulin activation of Phosphatidylinositol 3โ€“kinase in human skeletal muscle in vivo
  863. โ€ฆ is tyrosine-phosphorylated by interleukin-4 and enhances mitogenic and survival signals of interleukin-4 receptor by linking with the Phosphatidylinositol 3โ€ฒ-kinase โ€ฆ
  864. Phosphatidylinositol 3โ€“kinase inhibitors block aortic smooth muscle cell proliferation in mid-late G1 phase: effect on cyclin-dependent kinase 2 and the inhibitory โ€ฆ
  865. The Phosphatidylinositol 3โ€“kinase inhibitor wortmannin sensitizes quiescent but not proliferating MG-63 human osteosarcoma cells to radiation
  866. Contrasting Signaling Pathways of ฮฑ1A- and ฮฑ1B-Adrenergic Receptor Subtype Activation of Phosphatidylinositol 3โ€“kinase and Ras in Transfected NIH3T3 Cells
  867. Granulocyte-macrophage colony-stimulating factor and IL-5 activate mitogen-activated protein kinase through Jak2 kinase and Phosphatidylinositol 3โ€“kinase inhuman โ€ฆ
  868. Inositide signalling in Chlamydomonas: characterization of a Phosphatidylinositol 3โ€“kinase gene
  869. Suppression of insulin-stimulated Phosphatidylinositol 3โ€“kinase activity by the ฮฒ3-adrenoceptor agonist CL316243 in rat adipocytes
  870. Characterization of a novel tyrosine phosphorylated 100-kDa protein that binds to SHP-2 and Phosphatidylinositol 3โ€ฒ-kinase in myeloid cells
  871. Differential regulation of insulin receptor substrate-2 and mitogen-activated protein kinase tyrosine phosphorylation by Phosphatidylinositol 3โ€“kinase inhibitors in SH โ€ฆ
  872. โ€ฆ and protein kinase C in dibutyryl cAMP-differentiated U937 cells is dependent solely on the tyrosine-kinase activated form of Phosphatidylinositolโ€“3โ€“kinase
  873. โ€ฆ to membrane expansion during growth of cultured embryonic mouse hippocampal neurons: sensitivity to inhibitors of Phosphatidylinositol 3โ€“kinase and other protein โ€ฆ
  874. LY294002-mediated inhibition of Phosphatidylinositol 3โ€“kinase activity triggers growth inhibition and apoptosis in CD40-triggered Ramosโ€“Burkitt lymphoma B cells
  875. Oncogenic Ras-induced germinal vesicle breakdown is independent of Phosphatidylinositol 3โ€“kinase in Xenopus oocytes
  876. The structural requirement of Phosphatidylinositols as substrate of Phosphatidylinositol 3โ€“kinase
  877. Phosphatidylinositol 3โ€“kinase regulates differentiation of H9c2 cardiomyoblasts mainly through the protein kinase B/Akt-independent pathway
  878. H-ras induces glucose uptake in brown adipocytes in an insulin-and Phosphatidylinositol 3โ€“kinase-independent manner
  879. Interaction of Wild Type and Dominant-Negative p55PIK Regulatory Subunit of Phosphatidylinositol 3โ€“kinase with Insulin-Like Growth Factor-1 Signaling Proteins
  880. Activation of S6 kinase in human neutrophils by calcium pyrophosphate dihydrate crystals: protein kinase C-dependent and Phosphatidylinositolโ€“3โ€“kinase โ€ฆ
  881. EGF activates ErbB-2 and stimulates Phosphatidylinositol 3โ€“kinase in human airway smooth muscle cells
  882. CD16โ€mediated activation of Phosphatidylinositolโ€3 kinase (Plโ€3K) in human NK cells involves tyrosine phosphorylation of Cbl and its association with Grb2, Shc โ€ฆ
  883. Retinoic acid inhibits transformation by preventing Phosphatidylinositol 3โ€“kinase dependent activation of the c-fos promoter
  884. Binding of HIV-1 to its receptor induces tyrosine phosphorylation of several CD4-associated proteins, including the Phosphatidylinositol 3โ€“kinase
  885. โ€ฆ of bradykinin in the human colon carcinoma cell line SW-480 involves sequential activation of a Gq/11 protein, Phosphatidylinositol 3โ€“kinase ฮฒ, and protein โ€ฆ
  886. Insulin signalling in heart involves insulin receptor substrates-1 and-2, activation of Phosphatidylinositol 3โ€“kinase and the JAK 2-growth related pathway
  887. Wortmannin blocks goldfish retinal Phosphatidylinositol 3โ€“kinase and neurite outgrowth
  888. โ€ฆ transcription: involvement of the ligand-binding domain of the glucocorticoid receptor and independence from the Phosphatidylinositol 3โ€“kinase and mitogen-activated โ€ฆ
  889. Binding of CD4 ligands induces tyrosine phosphorylation of Phosphatidylinositolโ€“3 kinase p110 subunit.
  890. Involvement of Phosphatidylinositol 3โ€“kinase and mitogen-activated protein kinase pathways in AII-mediated enhanced expression of Gi proteins in vascular smooth โ€ฆ
  891. โ€ฆ -1โ€“induced cell-cycle progression: involvement of extracellular signal-regulated kinase, protein kinase C, and Phosphatidylinositol 3โ€“kinase at distinct points
  892. Phosphatidylinositol 3โ€“kinase in myogenesis
  893. Involvement of Phosphatidylinositol 3โ€“kinase in the mediation of erythropoietin-induced activation of p70S6k
  894. Liver microsomal glucose-6-phosphatase is competitively inhibited by the lipid products of Phosphatidylinositol 3โ€“kinase
  895. Interleukin-3 induces association of the protein-tyrosine phosphatase SHP2 and Phosphatidylinositol 3โ€“kinase with a 100-kDa tyrosine-phosphorylated โ€ฆ
  896. Structural and biochemical evaluation of the interaction of the Phosphatidylinositol 3โ€“kinase p85ฮฑ Src homology 2 domains with phosphoinositides and โ€ฆ
  897. Phosphatidylinositol 3โ€“kinase is required for the induction of ornithine decarboxylase in leukemia cells stimulated to growth
  898. Corneal epithelial wound healing increases the expression but not long lasting activation of the p85a subunit of Phosphatidylinositolโ€“3 kinase
  899. Wortmannin, a Phosphatidylinositol 3โ€“kinase inhibitor, blocks the assembly of peptide-MHC class II complexes.
  900. Design of peptidomimetics that inhibit the association of Phosphatidylinositol 3โ€“kinase with platelet-derived growth factor-ฮฒ receptor and possess cellular activity
  901. Monocyte adherence induced by lipopolysaccharide involves CD14, LFA-1, and cytohesin-1: regulation by Rho and Phosphatidylinositol 3โ€“kinase
  902. Inhibition of MGโ€63 cell proliferation and PDGFโ€stimulated cellular processes by inhibitors of Phosphatidylinositol 3โ€kinase
  903. Phosphorylation of Cbl following stimulation with interleukin-3 and its association with Grb2, Fyn, and Phosphatidylinositol 3โ€“kinase
  904. JNK/SAPK activation by platelet-derived growth factor in A431 cells requires both the phospholipase C-ฮณ and the Phosphatidylinositol 3โ€“kinase signaling pathways of โ€ฆ
  905. Evidence for Phosphatidylinositol 3โ€“kinase-dependent T cell antigen receptor (TCR) signal transduction
  906. Effects of Phosphatidylinositol 3โ€“kinase inhibitors, wortmannin and LY294002, on germinal vesicle breakdown (GVBD) in porcine oocytes
  907. Phosphatidylinositol 3โ€“kinase is not required for recycling of mannose 6-phosphate receptors from late endosomes to the trans-Golgi network.
  908. Islet transplantation restores normal levels of insulin receptor and substrate tyrosine phosphorylation and Phosphatidylinositol 3โ€“kinase activity in skeletal muscle and โ€ฆ
  909. Cripto-1 inhibits beta-casein expression in mammary epithelial cells through a p21ras-and Phosphatidylinositol 3โ€˜-kinase-dependent pathway.
  910. An Insulin-like Growth Factor-mediated, Phosphatidylinositol 3โ€ฒ kinase-independent Survival Signaling Pathway in ฮฒ Tumor Cells
  911. โ€ฆ a patient with severe insulin resistance: association of defective insulin-stimulated glucose transport with impaired Phosphatidylinositol 3โ€“kinase activity in fibroblasts
  912. Hydrogen peroxide-induced activation of SAPK/JNK regulated by Phosphatidylinositol 3โ€“kinase in Chinese hamster V79 cells
  913. Synergistic role of the Phosphatidylinositol 3โ€“kinase and mitogen-activated protein kinase cascade in the regulation of insulin receptor trafficking
  914. Evidence that thrombin-stimulated DNA synthesis in pulmonary arterial fibroblasts involves Phosphatidylinositol 3โ€“kinase-dependent p70 ribosomal S6 kinase โ€ฆ
  915. Phosphatidylinositol 3โ€ฒ-kinase associates with an insulin receptor substrate-1 serine kinase distinct from its intrinsic serine kinase
  916. Possibility of Distinct Insulin-Signaling Pathways Beyond Phosphatidylinositol 3โ€“kinaseโ€“Mediating Glucose Transport and Lipogenesis
  917. Insulinโ€stimulated cell growth in insulin receptor substrateโ€1โ€“deficient ZRโ€75โ€1 cells is mediated by a Phosphatidylinositolโ€3โ€kinaseโ€“independent pathway
  918. Down regulation of the expression of the p110, p85 and p55 subunits of Phosphatidylinositol 3โ€“kinase during colon cancer cell anchorage-independent growth.
  919. c-Src and Phosphatidylinositol 3โ€“kinase are involved in NGF-dependent tyrosine phosphorylation of Shc in PC12 cells
  920. Is stimulation of class-1 Phosphatidylinositol 3โ€“kinase activity by insulin sufficient to activate pathways involved in glucose metabolism.
  921. Phenylarsine oxide inhibits insulin activation of Phosphatidylinositol 3โ€ฒ-kinase
  922. Interaction of insulin receptor substrate-1 (IRS-1) with Phosphatidylinositol 3โ€“kinase: effect of substitution of serine for alanine in potential IRS-1 serine phosphorylation โ€ฆ
  923. Phosphorylation of the Grb2-and Phosphatidylinositol 3โ€“kinase p85โ€“binding p36/38 by Syk in Lck-Negative T Cells
  924. Tyrosine phosphorylation of Phosphatidylinositol 3โ€“kinase and of the thromboxane A2 (TXA2) receptor by the TXA2 mimetic I-BOP in A7r5 cells
  925. โ€ฆ in neonatal rat ventricular myocytes by Ras is mediated by Ral guanine nucleotide dissociation stimulator (Ral. GDS) and Phosphatidylinositol 3โ€“kinase in addition to โ€ฆ
  926. Effect of Ethanol on Intracellular Vesicular Transport from Golgi to the Apical Cell Membrane: Role of Phosphatidylinositol 3โ€kinase and Phospholipase A2 in Golgi โ€ฆ
  927. Evidence that a kinase distinct from protein kinase C and Phosphatidylinositol 3โ€“kinase mediates ligation-dependent serine/threonine phosphorylation of the T โ€ฆ
  928. Interleukin-4 (IL-4) induces Phosphatidylinositol 3โ€“kinase (p85) dephosphorylation: implications for the role of SHP-1 in the IL-4-induced signals in human B โ€ฆ
  929. Inhibition of Kit expression by IL-4 and IL-10 in murine mast cells: role of STAT6 and Phosphatidylinositol 3โ€ฒ-kinase
  930. Phosphatidylinositol 3โ€“kinase is required for the regulation of hepatitis B surface antigen production and mitogen-activated protein kinase activation by insulin but not โ€ฆ
  931. Formation of distinct signalling complexes involving Phosphatidylinositol 3โ€kinase activity with stimulation of epidermal growth factor or insulinโ€like growth factorโ€I in โ€ฆ
  932. Secretory IgA-mediated basophil activation: II. Roles of GTP-binding regulatory proteins and Phosphatidylinositol 3โ€“kinase
  933. Identification of protein kinase B (PKB) as a Phosphatidylinositol 3, 4, 5-trisphosphate binding protein in Dictyostelium discoideum
  934. Density dependent elevation of Phosphatidylinositolโ€“3 kinase level in rat 3Y1 cells
  935. CD40-triggered protein tyrosine phosphorylation on Vav and on Phosphatidylinositol 3โ€“kinase correlates with survival of the Ramosโ€“Burkitt lymphoma B cell line
  936. Phosphatidylinositol 3โ€“kinase translocation to the nucleus is an early event in the interleukin-1 signalling mechanism in human osteosarcoma Saos-2 cells.
  937. โ€ฆ and insensitive intracellular signalling pathways in undifferentiated 3T3โ€L1 cells stimulated by insulin converge with Phosphatidylinositol 3โ€kinase upstream of the โ€ฆ
  938. Phosphatidylinositol 3โ€ฒ-kinase is associated with a serine kinase that is activated by okadaic acid
  939. Phosphatidylinositol 3โ€“kinase in Cumulus Cells is Responsible for Meiotic Progression from MI to M II Stage in Porcine Follicular Oocytes
  940. IL-2, but not IL-4 and other cytokines, induces phosphorylation of a 98-kDa protein associated with SHP-2, Phosphatidylinositol 3โ€ฒ-kinase, and Grb2
  941. โ€ฆ Nucleotide Exchange Factor and Ha-Ras: EVIDENCES FOR A FUNCTION OF Raf-1 AND Phosphatidylinositol 3โ€“kinase UPSTREAM TO Ras
  942. โ€ฆ in tyrosine phosphorylation of insulin receptor and insulin receptor substrate-1 (IRS-1) and association of p85 subunit of Phosphatidylinositol 3โ€“kinase with IRS-1 after โ€ฆ
  943. Polymorphism and CHโ€ฆ O interaction of wortmannin, a Phosphatidylinositol 3โ€“kinase inhibitor
  944. โ€ฆ stimulation lowers the activation threshold and enhances the alloreactivity of cord blood T cells by activating the Phosphatidylinositol 3โ€“kinase pathway and inducing โ€ฆ
  945. โ€ฆ ) and activating protein 1 (AP-1) by oncogenic 70Z Cbl requires an intact phosphotyrosine binding domain but not Crk (L) or p85 Phosphatidylinositol 3โ€“kinase โ€ฆ
  946. Role of Phosphatidylinositol 3โ€“kinase in platelet aggregation
  947. Downโ€regulation of LFAโ€1โ€mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires Phosphatidylinositolโ€3โ€kinase activity
  948. Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing Phosphatidylinositol signaling molecules
  949. โ€ฆ -(Hexadecyloxy)-3 (5)-Methoxybutanephosphonate (C4-PI), Inhibits Epithelial Cell Proliferation and is a Substrate but not an Inhibitor of Phosphatidylinositol 3โ€“kinase
  950. Up-regulation of Phosphatidylinositol 3โ€“kinase in psoriatic lesions
  951. โ€ฆ of connexin-43, gap junctional protein, in cumulus cells is regulated by mitogen-activated protein kinase and Phosphatidylinositol 3โ€“kinase during in vitro meiotic โ€ฆ
  952. Inhibition of Phosphatidylinositol 3โ€“kinase
  953. 1 , 25-Dihydroxyvitamin D 3โ€“induced Myeloid Cell Differentiation Is Regulated by a Vitamin D Receptorโ€“Phosphatidylinositol 3โ€“kinase Signaling Complex
  954. Immunocytochemical detection of Phosphatidylinositol 3 kinase in Burkitt lymphoma cells
  955. Defect in long-term activation of Phosphatidylinositol 3โ€“kinase by insulin in vivo: studies in insulin-resistant hHTg rats
  956. Hexamethylenebisacetamide modulation of thyroglobulin and protein levels in thyroid cells is not mediated by Phosphatidylinositolโ€“3โ€“kinase: A study with wortmannin
  957. The regulation and function of Phosphatidylinositol 3โ€“kinase
  958. A role for Phosphatidylinositol 3โ€“kinase in platelet aggregation
  959. Activation of the Phosphatidylinositol 3โ€“kinase Serine kinase by 1FN-aโ€™
  960. Phosphatidylinositol 3โ€“kinase mediates interleukin-l-induced activation of NFB and AP-1 Shrikanth
  961. Regulation of the p85/p110 Phosphatidylinositol 3โ€“kinase
  962. Through Phosphatidylinositol 3โ€“kinase in Rat Heart
  963. Cloning and characterisation of novel isoforms of Phosphatidylinositol 3โ€“kinase
  964. REGULATION OF CHOLANGIOCYTE CL SECRETION BY Phosphatidylinositol 3โ€“kinase
  965. Bidirectional Effect of Regulatory Subunits of Phosphatidylinositol 3โ€“kinase Dependent Signalling Pathway
  966. Role of Phosphatidylinositol 3โ€“kinase as an effector of Ras
  967. Mechanism of radiation sensitization by wortmannin, a Phosphatidylinositolโ€“3 kinase inhibitor
  968. Up-regulation of Phosphatidylinositol 3โ€“kinase in psoriatic lesions
  969. Activation of Phosphatidylinositol 3โ€“kinase via epidermal growth factor receptor in isolated rat hepatocytes
  970. Studies of a Phosphatidylinositol 3โ€“kinase complex linked to vesicular trafficking in human cells
  971. Comparison of insulin and platelet-derived growth factor signaling: focusing on Phosphatidylinositol 3โ€“kinase
  972. Activation of p70S6K and ERK as well as Akt by Heat Shock and Hyperosmorality Stress is Phosphatidylinositol 3โ€“kinase Dependent
  973. Inhibition of proliferation by wortmannin through the blokade of Phosphatidylinositol 3โ€“kinase in mast cell line P815
  974. Antagonists of Phosphatidylinositol 3โ€“kinase block phosphorylation-dependent activation of the leukocyte NADPH oxidase in a cell-free system
  975. Phosphatidylinositol 3โ€“kinase AND cAMP INVOLVEMENT IN THE GROWTH HORMONE REGULATION OF ION TRANSPORT IN CACO-2 CELLS
  976. Serendipitous studies in cell signaling: The role of Phosphatidylinositol 3โ€“kinase (PI3K) in signal transduction, identification of new PI3K targets, and the โ€ฆ
  977. Activation of Phosphatidylinositol 3โ€“kinase by interleukin-13 in colonic epithelial cells: regulation of nitric oxide and apoptosis
  978. Phosphatidylinositolโ€“3 kinase dependent pathways: the role in control of cell growth, survival, and malignant transformation.
  979. Beclinโ€“Phosphatidylinositol 3โ€“kinase complex functions at the trans-Golgi network
  980. Phosphatidylinositol 3โ€“kinase signaling controls levels of hypoxia-inducible factor
  981. New role for Shc in activation of the Phosphatidylinositol 3โ€“kinase/Akt pathway
  982. Regulation of B-cell activation and differentiation by the Phosphatidylinositol 3โ€“kinase and phospholipase Cgamma pathway.
  983. Phosphatidylinositol 3โ€“kinase/AKT-mediated activation of estrogen receptor ฮฑ: a new model for anti-estrogen resistance
  984. Phosphatidylinositol 3โ€“kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells
  985. Tyrosine phosphorylation of p85 relieves its inhibitory activity on Phosphatidylinositol 3โ€“kinase
  986. A Phosphatidylinositol 3โ€“kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
  987. The Phosphatidylinositol 3โ€ฒ-kinase p85ฮฑ gene is an oncogene in human ovarian and colon tumors
  988. Two Distinct Vps34 Phosphatidylinositol 3โ€“kinase Complexes Function in Autophagy and Carboxypeptidase Y Sorting inSaccharomyces cerevisiae
  989. Regulation of neutrophil apoptosis: a role for protein kinase C and Phosphatidylinositolโ€“3โ€“kinase
  990. Ischemic preconditioning activates Phosphatidylinositolโ€“3โ€“kinase upstream of protein kinase C
  991. Role of Phosphatidylinositol 3โ€“kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesis
  992. Phosphatidylinositol 3โ€“kinase signaling inhibits DAF-16 DNA binding and function via 14-3โ€“3-dependent and 14-3โ€“3-independent pathways
  993. Phosphatidylinositol 3โ€“kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis
  994. Phosphatidylinositol 3โ€kinase mediates neuroprotection by estrogen in cultured cortical neurons
  995. Anti-apoptotic signaling by hepatocyte growth factor/Met via the Phosphatidylinositol 3โ€“kinase/Akt and mitogen-activated protein kinase pathways
  996. Phosphatidylinositol 3โ€“kinase regulates Raf1 through Pak phosphorylation of serine 338
  997. Transforming ability of MEN2A-RET requires activation of the Phosphatidylinositol 3โ€“kinase/AKT signaling pathway
  998. Phosphatidylinositol 3โ€“kinase as a mediator of TNF-induced NF-ฮบB activation
  999. Expression of constitutively active Phosphatidylinositol 3โ€“kinase inhibits activation of caspase 3 and apoptosis of cardiac muscle cells
  1000. In Vivo and in Vitro Ovarian Carcinoma Growth Inhibition by a Phosphatidylinositol 3โ€“kinase Inhibitor (LY294002)
  1001. Opposing actions of Phosphatidylinositol 3โ€kinase and glycogen synthase kinaseโ€3ฮฒ in the regulation of HSFโ€1 activity
  1002. Phosphatidylinositol 3โ€“kinase function is required for transforming growth factor ฮฒ-mediated epithelial to mesenchymal transition and cell migration
  1003. Substrate specificity of ฮฑvฮฒ3integrin-mediated cell migration and Phosphatidylinositol 3โ€“kinase/AKT pathway activation
  1004. Role of reactive oxygen species and Phosphatidylinositol 3โ€“kinase in cardiomyocyte differentiation of embryonic stem cells
  1005. Phosphatidylinositol 3โ€“kinase/Akt activity regulates c-FLIP expression in tumor cells
  1006. The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the Phosphatidylinositol 3โ€“kinase/protein kinase B pathway
  1007. The Phosphatidylinositol 3โ€“kinase/AKT kinase pathway in multiple myeloma plasma cells: roles in cytokine-dependent survival and proliferative responses
  1008. Myotubularin, a phosphatase deficient in myotubular myopathy, acts on Phosphatidylinositol 3โ€“kinase and Phosphatidylinositol 3-phosphate pathway
  1009. Insulin-like growth factor-mediated muscle differentiation: collaboration between Phosphatidylinositol 3โ€“kinase-Akt-signaling pathways and myogenin
  1010. The ฮฒ2-Adrenergic Receptor Delivers an Antiapoptotic Signal to Cardiac Myocytes Through Gi-Dependent Coupling to Phosphatidylinositol 3โ€ฒ-kinase
  1011. Phosphatidylinositol 3โ€“kinase activity in epidermal growth factor-stimulated matrix metalloproteinase-9 production and cell surface association
  1012. The osteopontin-CD44 survival signal involves activation of the Phosphatidylinositol 3โ€“kinase/Akt signaling pathway
  1013. Latent membrane protein 2A-mediated effects on the Phosphatidylinositol 3โ€“kinase/Akt pathway
  1014. The p75 neurotrophin receptor activates Akt (protein kinase B) through a Phosphatidylinositol 3โ€“kinase-dependent pathway
  1015. Pancreatic cancer cell proliferation is Phosphatidylinositol 3โ€“kinase dependent
  1016. Lipoarabinomannan from Mycobacterium tuberculosis promotes macrophage survival by phosphorylating Bad through a Phosphatidylinositol 3โ€“kinase/Akt โ€ฆ
  1017. Kit/stem cell factor receptor-induced activation of Phosphatidylinositol 3โ€ฒ-kinase is essential for male fertility
  1018. Hypoxia activates a platelet-derived growth factor receptor/Phosphatidylinositol 3โ€“kinase/Akt pathway that results in glycogen synthase kinaseโ€“3 inactivation
  1019. Insulin rescues retinal neurons from apoptosis by a Phosphatidylinositol 3โ€“kinase/Akt-mediated mechanism that reduces the activation of caspase-3
  1020. Regulation of the protein kinase Raf-1 by oncogenic Ras through Phosphatidylinositol 3โ€“kinase, Cdc42/Rac and Pak
  1021. BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the Phosphatidylinositol 3โ€“kinase/AKT pathway
  1022. A novel role for Phosphatidylinositol 3โ€“kinase ฮฒ in signaling from G protein-coupled receptors to Akt
  1023. Platelet-derived growth factor-induced H2O2 production requires the activation of Phosphatidylinositol 3โ€“kinase
  1024. Modulation of hypoxia-inducible factor 1ฮฑ expression by the epidermal growth factor/Phosphatidylinositol 3โ€“kinase/PTEN/AKT/FRAP pathway in human prostate โ€ฆ
  1025. Regulation of melanogenesis through Phosphatidylinositol 3โ€“kinase-Akt pathway in human G361 melanoma cells
  1026. Hypoxia induces the activation of the Phosphatidylinositol 3โ€“kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis
  1027. Cytokines promote motoneuron survival through the Janus kinase-dependent activation of the Phosphatidylinositol 3โ€“kinase pathway
  1028. Nucleophosminโ€“anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the Phosphatidylinositol 3โ€“kinase/Akt antiapoptotic signaling โ€ฆ
  1029. A Phosphatidylinositol 3โ€“kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor โ€ฆ
  1030. Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant
  1031. ฮฑ7 nicotinic receptor transduces signals to Phosphatidylinositol 3โ€“kinase to block A ฮฒ-amyloid-induced neurotoxicity
  1032. The bile acid taurochenodeoxycholate activates a Phosphatidylinositol 3โ€“kinase-dependent survival signaling cascade
  1033. The hepatitis B virus-X protein activates a Phosphatidylinositol 3โ€“kinase-dependent survival signaling cascade
  1034. Phosphorylation of PDE3B by Phosphatidylinositol 3โ€“kinase associated with the insulin receptor
  1035. Phosphatidylinositol 3โ€“kinase, not extracellular signal-regulated kinase, regulates activation of the antioxidant-responsive element in IMR-32 human โ€ฆ
  1036. A specific function for Phosphatidylinositol 3โ€“kinase ฮฑ (p85ฮฑ-p110ฮฑ) in cell survival and for Phosphatidylinositol 3โ€“kinase ฮฒ (p85ฮฑ-p110ฮฒ) in de novo DNA synthesis of โ€ฆ
  1037. Stimulation of Phosphatidylinositol 3โ€“kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins
  1038. Overexpression of Phosphatidylinositol 3โ€“kinase in human lung cancer
  1039. Angiopoietin-1 regulates endothelial cell survival through the Phosphatidylinositol 3โ€ฒ-kinase/Akt signal transduction pathway
  1040. Restricted accumulation of Phosphatidylinositol 3โ€“kinase products in a plasmalemmal subdomain during Fcฮณ receptor-mediated phagocytosis
  1041. Inhibition of mitogen-activated protein kinase and Phosphatidylinositol 3โ€“kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis
  1042. Role of Phosphatidylinositol 3โ€“kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest
  1043. Roles of Phosphatidylinositol 3โ€“kinase in interferon-ฮณ-dependent phosphorylation of STAT1 on serine 727 and activation of gene expression
  1044. Phosphatidylinositol 3โ€“kinase is required for insulin-like growth factor-Iโ€“induced vascular smooth muscle cell proliferation and migration
  1045. Association of Phosphatidylinositol 3โ€“kinase with nuclear transcription sites in higher plants
  1046. A novel positive feedback loop mediated by the docking protein Gab1 and Phosphatidylinositol 3โ€“kinase in epidermal growth factor receptor signaling
  1047. Human cytomegalovirus up-regulates the Phosphatidylinositol 3โ€“kinase (PI3-K) pathway: inhibition of PI3-K activity inhibits viral replication and virus-induced signaling
  1048. โ€ฆ endothelial growth factor induces expression of connective tissue growth factor via KDR, Flt1, and Phosphatidylinositol 3โ€“kinase-akt-dependent pathways in โ€ฆ
  1049. Signaling complexes and protein-protein interactions involved in the activation of the Ras and Phosphatidylinositol 3โ€“kinase pathways by the c-Ret receptor โ€ฆ
  1050. Hepatitis B virus X protein inhibits transforming growth factor-ฮฒ-induced apoptosis through the activation of Phosphatidylinositol 3โ€“kinase pathway
  1051. Haptotactic migration induced by midkine: involvement of protein-tyrosine phosphatase ฮถ, mitogen-activated protein kinase, and Phosphatidylinositol 3โ€“kinase
  1052. The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and-independent pathways: roles for Phosphatidylinositol 3โ€“kinase and Raf
  1053. Interferon ฮฑ/ฮฒ promotes cell survival by activating nuclear factor ฮบB through Phosphatidylinositol 3โ€“kinase and Akt
  1054. Angiopoietin-2 at high concentration can enhance endothelial cell survival through the Phosphatidylinositol 3โ€ฒ-kinase/Akt signal transduction pathway
  1055. A Phosphatidylinositol 3โ€“kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFฮบB in human โ€ฆ
  1056. Induction of vascular endothelial growth factor receptors and Phosphatidylinositol 3โ€ฒ-kinase/Akt signaling by global cerebral ischemia in the rat
  1057. โ€ฆ life span of skeletal muscle satellite cells by enhancing g1/s cell cycle progression via the activation of Phosphatidylinositol 3โ€ฒ-kinase/akt signaling pathway
  1058. Phosphatidylinositol 3โ€“kinase, Cdc42, and Rac1 act downstream of Ras in integrin-dependent neurite outgrowth in N1E-115 neuroblastoma cells
  1059. Adrenomedullin induces endothelium-dependent vasorelaxation via the Phosphatidylinositol 3โ€“kinase/Aktโ€“dependent pathway in rat aorta
  1060. Association of increased Phosphatidylinositol 3โ€“kinase signaling with increased invasiveness and gelatinase activity in malignant gliomas
  1061. Glycogen synthase kinaseโ€“3ฮฒ activity is critical for neuronal death caused by inhibiting Phosphatidylinositol 3โ€“kinase or Akt but not for death caused by nerve โ€ฆ
  1062. The insulin-like growth factor-Phosphatidylinositol 3โ€“kinase-Akt signaling pathway regulates myogenin expression in normal myogenic cells but not in โ€ฆ
  1063. Phosphatidylinositol 3โ€“kinase/Akt signaling controls endothelial cell sensitivity to Fas-mediated apoptosis via regulation of FLICE-inhibitory protein (FLIP)
  1064. Inhibition of the Phosphatidylinositol 3โ€“kinase pathway contributes to HT29 and Caco-2 intestinal cell differentiation
  1065. A member of Forkhead family transcription factor, FKHRL1, is one of the downstream molecules of Phosphatidylinositol 3โ€“kinase-Akt activation pathway in โ€ฆ
  1066. Human SMG-1, a novel Phosphatidylinositol 3โ€“kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the โ€ฆ
  1067. Redistribution of Brutonโ€™s tyrosine kinase by activation of Phosphatidylinositol 3โ€kinase and Rhoโ€family GTPases
  1068. Parallel and independent regulation of interleukin-3 mRNA turnover by Phosphatidylinositol 3โ€“kinase and p38 mitogen-activated protein kinase
  1069. Phosphatidylinositol 3โ€“kinase C2ฮฑ contains a nuclear localization sequence and associates with nuclear speckles
  1070. The Phosphatidylinositol 3โ€“kinase/AKT Signal Transduction Pathway Plays a Critical Role in the Expression of p21WAF1/CIP1/SDI1 Induced by Cisplatin and โ€ฆ
  1071. Amino acid-induced translation of TOP mRNAs is fully dependent on Phosphatidylinositol 3โ€“kinase-mediated signaling, is partially inhibited by rapamycin, and is โ€ฆ
  1072. Nerve growth factor functions as a chemoattractant for mast cells through both mitogen-activated protein kinase and Phosphatidylinositol 3โ€“kinase signaling pathways
  1073. Role of Phosphatidylinositol 3โ€ฒ kinase and a Downstream Pleckstrin Homology Domainโ€“Containing Protein in Controlling Chemotaxis inDictyostelium
  1074. Prevention of Phosphatidylinositol 3โ€ฒ-kinase-Akt survival signaling pathway during topotecan-induced apoptosis
  1075. Signal transduction by the chemokine receptor CXCR3: activation of Ras/ERK, Src, and Phosphatidylinositol 3โ€“kinase/Akt controls cell migration and โ€ฆ
  1076. Oleate activates Phosphatidylinositol 3โ€“kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite โ€ฆ
  1077. Myogenic differentiation requires signalling through both Phosphatidylinositol 3โ€“kinase and p38 MAP kinase
  1078. Insulin-induced actin filament remodeling colocalizes actin with Phosphatidylinositol 3โ€“kinase and GLUT4 in L6 myotubes
  1079. โ€ฆ up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving Phosphatidylinositol 3โ€ฒ-kinase and distinct from that โ€ฆ
  1080. Insulin Activates ATP-Sensitive K+ Channels in Pancreatic ฮฒ-Cells Through a Phosphatidylinositol 3โ€“kinaseโ€“Dependent Pathway
  1081. Interferon-ฮฑ promotes survival of human primary B-lymphocytes via Phosphatidylinositol 3โ€“kinase
  1082. โ€ฆ acetate induces neutrophil NADPHโ€oxidase activity by two separate signal transduction pathways: dependent or independent of Phosphatidylinositol 3โ€kinase
  1083. The role of genetic abnormalities of PTEN and the Phosphatidylinositol 3โ€“kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy
  1084. Phosphatidylinositol 3โ€“kinase inhibition enhances human sperm motility
  1085. Extracellular zinc activates p70 S6 kinase through the Phosphatidylinositol 3โ€“kinase signaling pathway
  1086. Cooperative signaling between ฮฑ6ฮฒ4integrin and ErbB-2 receptor is required to promote Phosphatidylinositol 3โ€“kinase-dependent invasion
  1087. โ€ฆ -inducible factor (HIF)-1ฮฑ, HIF-2ฮฑ, and vascular endothelial growth factor expression and their regulation by the Phosphatidylinositol 3โ€ฒ-kinase/Akt signaling pathway
  1088. ฮฑ5ฮฒ1 integrin protects intestinal epithelial cells from apoptosis through a Phosphatidylinositol 3โ€“kinase and protein kinase Bโ€“dependent pathway
  1089. Protein kinase C-ฮถ phosphorylates insulin receptor substrate-1 and impairs its ability to activate Phosphatidylinositol 3โ€“kinase in response to insulin
  1090. Cell cycle protein expression in vascular smooth muscle cells in vitro and in vivo is regulated through Phosphatidylinositol 3โ€“kinase and mammalian target of โ€ฆ
  1091. The EphA8 receptor regulates integrin activity through p110ฮณ Phosphatidylinositolโ€“3 kinase in a tyrosine kinase activity-independent manner
  1092. The tyrosine phosphatase SHP-2 is required for mediating Phosphatidylinositol 3โ€“kinase/Akt activation by growth factors
  1093. Growth hormone induces cellular insulin resistance by uncoupling Phosphatidylinositol 3โ€“kinase and its downstream signals in 3T3-L1 adipocytes
  1094. โ€ฆ : Neuroprotection mediated by glial groupโ€II metabotropic glutamate receptors requires the activation of the MAP kinase and the Phosphatidylinositolโ€3โ€kinase โ€ฆ
  1095. Scatter factor/hepatocyte growth factor protects against cytotoxic death in human glioblastoma via Phosphatidylinositol 3โ€“kinase-and AKT-dependent pathways
  1096. Cyclic AMP inhibits extracellular signal-regulated kinase and Phosphatidylinositol 3โ€“kinase/Akt pathways by inhibiting Rap1
  1097. The classical progesterone receptor associates with p42 MAPK and is involved in Phosphatidylinositol 3โ€“kinase signaling inXenopus oocytes
  1098. Cbl-b, a RING-type E3 ubiquitin ligase, targets Phosphatidylinositol 3โ€“kinase for ubiquitination in T cells
  1099. The inhibition of Phosphatidylinositolโ€3โ€kinase induces neurite retraction and activates GSK3
  1100. Inhibitory mechanisms of tea polyphenols on the ultraviolet B-activated Phosphatidylinositol 3โ€“kinase-dependent pathway
  1101. Preconditioning enhanced glucose uptake is mediated by p38 MAP kinase not by Phosphatidylinositol 3โ€“kinase
  1102. Tec kinase signaling in T cells is regulated by Phosphatidylinositol 3โ€“kinase and the Tec pleckstrin homology domain
  1103. Trypanosoma cruzi: Phosphatidylinositol 3โ€“kinase and protein kinase B activation is associated with parasite invasion
  1104. A Phosphatidylinositol 3โ€“kinase docking site in the cytoplasmic tail of the Jaagsiekte sheep retrovirus transmembrane protein is essential for envelope-induced โ€ฆ
  1105. Phosphatidylinositol 3โ€kinase and mTOR mediate lipopolysaccharideโ€stimulated nitric oxide production in macrophages via interferonโ€ฮฒ
  1106. Epstein-Barr virus immediate-early protein BRLF1 induces the lytic form of viral replication through a mechanism involving Phosphatidylinositolโ€“3 kinase activation
  1107. L-leucine availability regulates Phosphatidylinositol 3โ€“kinase, p70 S6 kinase and glycogen synthase kinaseโ€“3 activity in L6 muscle cells: evidence for the involvement โ€ฆ
  1108. Glycoprotein 130 regulates cardiac myocyte survival in doxorubicin-induced apoptosis through Phosphatidylinositol 3โ€“kinase/Akt phosphorylation and Bcl-xL/caspase โ€ฆ
  1109. Role of extracellular signal-regulated kinase and Phosphatidylinositolโ€“3 kinase in chemoattractant and LPS delay of constitutive neutrophil apoptosis
  1110. TNF-ฮฑ-induced sphingosine 1-phosphate inhibits apoptosis through a Phosphatidylinositol 3โ€“kinase/Akt pathway in human hepatocytes
  1111. Activation of Phosphatidylinositol 3โ€“kinase and Akt bytert-butylhydroquinone is responsible for antioxidant response element-mediated rGSTA2 induction in H4IIE cells
  1112. Erythropoietin regulates vascular smooth muscle cell apoptosis by a Phosphatidylinositol 3 kinase-dependent pathway
  1113. S338 phosphorylation of Raf-1 is independent of Phosphatidylinositol 3โ€“kinase and Pak3
  1114. โ€ฆ factor rapidly increases activity and cell surface expression of the EAAC1 subtype of glutamate transporter through activation of Phosphatidylinositol 3โ€“kinase
  1115. Oncogenic Ras blocks anoikis by activation of a novel effector pathway independent of Phosphatidylinositol 3โ€“kinase
  1116. Up-regulation of urokinase-type plasminogen activator by insulin-like growth factor-I depends upon Phosphatidylinositolโ€“3 kinase and mitogen-activated protein โ€ฆ
  1117. TEL-JAK2 mediates constitutive activation of the Phosphatidylinositol 3โ€ฒ-kinase/protein kinase B signaling pathway
  1118. An inhibitory role of the Phosphatidylinositol 3โ€“kinase-signaling pathway in vascular endothelial growth factor-induced tissue factor expression
  1119. โ€ฆ fructose absorption by the extracellular signal-regulated kinase, p38 mitogen-activated kinase and Phosphatidylinositol 3โ€“kinase intracellular signalling pathways โ€ฆ
  1120. c-Src is required for glial cell line-derived neurotrophic factor (GDNF) family ligand-mediated neuronal survival via a Phosphatidylinositolโ€“3 kinase (PI-3K)-dependent โ€ฆ
  1121. โ€ฆ neurotrophic factor (BDNF) induces dendritic targeting of BDNF and tyrosine kinase B mRNAs in hippocampal neurons through a Phosphatidylinositolโ€“3 kinase โ€ฆ
  1122. Urokinase stimulates human vascular smooth muscle cell migration via a Phosphatidylinositol 3โ€“kinase-Tyk2 interaction
  1123. Phosphatidylinositol 3โ€kinase and ERK are required for NFโ€ฮบB activation but not for phagocytosis
  1124. Phosphatidylinositol 3โ€“kinase potentiates, but does not trigger, T cell proliferation mediated by the IL-2 receptor
  1125. Quercetin inhibits Shc-and Phosphatidylinositol 3โ€“kinase-mediated c-Jun N-terminal kinase activation by angiotensin II in cultured rat aortic smooth muscle cells
  1126. Differential effects of Phosphatidylinositol 3โ€“kinase inhibition on intracellular signals regulating GLUT4 translocation and glucose transport
  1127. Regulation of gene expression by glucose in pancreatic ฮฒ-cells (MIN6) via insulin secretion and activation of Phosphatidylinositol 3โ€ฒ-kinase
  1128. The essential role of Phosphatidylinositol 3โ€“kinase and of p38 mitogen-activated protein kinase activation in the antioxidant response element-mediated rGSTA2 โ€ฆ
  1129. Phosphatidylinositol 3โ€“kinase signaling is important for smooth muscle cell replication after arterial injury
  1130. Trypanosoma cruzi trans-sialidase: A potent and specific survival factor for human Schwann cells by means of Phosphatidylinositol 3โ€“kinase/Akt signaling
  1131. C5b-9 terminal complement complex protects oligodendrocytes from death by regulating Bad through Phosphatidylinositol 3โ€“kinase/Akt pathway
  1132. Putative role of the Phosphatidylinositol 3โ€“kinaseโ€”Akt signaling pathway in the survival of granulosa cells
  1133. Activation of Phosphatidylinositolโ€“3 kinase (PI-3K) and extracellular regulated kinases (Erk1/2) is involved in muscarinic receptor-mediated DNA synthesis in neural โ€ฆ
  1134. Insulin accelerates inter-endosomal GLUT4 traffic via Phosphatidylinositol 3โ€“kinase and protein kinase B
  1135. The Ras/Phosphatidylinositol 3โ€“kinase and Ras/ERK pathways function as independent survival modules each of which inhibits a distinct apoptotic signaling โ€ฆ
  1136. A Novel B Lymphocyteโ€“associated Adaptor Protein, Bam32, Regulates Antigen Receptor Signaling Downstream of Phosphatidylinositol 3โ€“kinase
  1137. Involvement of the pathway Phosphatidylinositolโ€“3โ€“kinase/AKT-1 in the establishment of the survival response to ionizing radiation
  1138. Reduction of potassium currents and Phosphatidylinositol 3โ€“kinase-dependent AKT phosphorylation by tumor necrosis factor-ฮฑ rescues axotomized retinal ganglion โ€ฆ
  1139. Novel role of Phosphatidylinositol 3โ€“kinase in CD28-mediated costimulation
  1140. Hepatocyte growth factor protects cultured rat cerebellar granule neurons from apoptosis via the Phosphatidylinositolโ€3 kinase/Akt pathway
  1141. Halenaquinone, a novel Phosphatidylinositol 3โ€“kinase inhibitor from a marine sponge, induces apoptosis in PC12 cells
  1142. Stem cell factor induces Phosphatidylinositol 3โ€ฒ-kinaseโ€“dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells
  1143. X-linked inhibitor of apoptosis protein activates the Phosphatidylinositol 3โ€“kinase/Akt pathway in rat granulosa cells during follicular development
  1144. Phosphatidylinositolโ€“3 kinase and extracellular signal-regulated kinase mediate the chemotactic and mitogenic effects of insulin-like growth factor-I in human hepatic โ€ฆ
  1145. Thapsigargin-induced degranulation of mast cells is dependent on transient activation of Phosphatidylinositolโ€“3 kinase
  1146. Phosphatidylinositol 3โ€“kinase is necessary but not sufficient for thrombopoietin-induced proliferation in engineered Mpl-bearing cell lines as well as in primary โ€ฆ
  1147. Specific requirement for the p85-p110ฮฑ Phosphatidylinositol 3โ€“kinase during epidermal growth factor-stimulated actin nucleation in breast cancer cells
  1148. Cooperative regulation of Mcl-1 by Janus kinase/stat and Phosphatidylinositol 3โ€“kinase contribute to granulocyte-macrophage colony-stimulating factor-delayed โ€ฆ
  1149. Phosphatidylinositolโ€“3 kinase acts in parallel to the ERK MAP kinase in the FGF pathway during Xenopus mesoderm induction
  1150. Phosphatidylinositol 3โ€ฒ kinase signaling in mammary tumorigenesis
  1151. Neuregulin rescues PC12-ErbB4 cells from cell death induced by H2O2: regulation of reactive oxygen species levels by Phosphatidylinositol 3โ€“kinase
  1152. Apoptosis suppression by Raf-1 and MEK1 requires MEK-and Phosphatidylinositol 3โ€“kinase-dependent signals
  1153. Insulin regulates alternative splicing of protein kinase C ฮฒII through a Phosphatidylinositol 3โ€“kinase-dependent pathway involving the nuclear serine/arginine โ€ฆ
  1154. fMet-Leu-Phe stimulates proinflammatory cytokine gene expression in human peripheral blood monocytes: the role of Phosphatidylinositol 3โ€“kinase
  1155. Retention of PDGFR-ฮฒ function in mice in the absence of Phosphatidylinositol 3โ€ฒ-kinase and phospholipase Cฮณ signaling pathways
  1156. Activation of the Ral and Phosphatidylinositol 3โ€ฒ kinase signaling pathways by the ras-related protein TC21
  1157. The SH3 domain directs acto-myosin-dependent targeting of v-Src to focal adhesions via Phosphatidylinositol 3โ€“kinase
  1158. Caveolin 1-mediated regulation of receptor tyrosine kinase-associated Phosphatidylinositol 3โ€“kinase activity by ceramide
  1159. Phosphatidylinositol 3โ€“kinase activation and interaction with focal adhesion kinase in Escherichia coli K1 invasion of human brain microvascular endothelial โ€ฆ
  1160. Targets of B-cell antigen receptor signaling: the Phosphatidylinositol 3โ€“kinase/Akt/glycogen synthase kinaseโ€“3 signaling pathway and the Rap1 GTPase.
  1161. Regulation of Cyclin D1 Expression and DNA Synthesis by Phosphatidylinositol 3โ€“kinase in Airway Smooth Muscle Cells
  1162. Interleukinโ€6 activates Phosphatidylinositolโ€3 kinase, which inhibits apoptosis in human prostate cancer cell lines
  1163. Cooperation between STAT5 and Phosphatidylinositol 3โ€“kinase in the IL-3-dependent survival of a bone marrow derived cell line
  1164. Endocytosis and nuclear trafficking of adeno-associated virus type 2 are controlled by rac1 and Phosphatidylinositolโ€“3 kinase activation
  1165. Phosphatidylinositol 3โ€“kinase-dependent stabilization of ฮฑ1(I) collagen mRNA in human lung fibroblasts
  1166. GTPases and Phosphatidylinositol 3โ€“kinase are critical for insulin-like growth factor-I-mediated Schwann cell motility
  1167. The role of Phosphatidylinositol 3โ€“kinase and the mitogen-activated protein kinases in insulin-like growth factor-I-mediated effects in vascular endothelial cells
  1168. Thrombopoietin potentiates collagen receptor signaling in platelets through a Phosphatidylinositol 3โ€“kinaseโ€“dependent pathway
  1169. Regulation of intracellular trafficking of the EGF receptor by Rab5 in the absence of Phosphatidylinositol 3โ€“kinase activity
  1170. NK cellโ€mediated lysis of autologous antigenโ€presenting cells is triggered by the engagement of the Phosphatidylinositol 3โ€kinase upon ligation of the natural โ€ฆ
  1171. Role of Gab proteins in Phosphatidylinositol 3โ€“kinase activation by thrombopoietin (Tpo)
  1172. Phosphatidylinositol 3โ€“kinase and NF-ฮบB/Rel are at the divergence of CD40-mediated proliferation and survival pathways
  1173. Distinct roles for extracellular-signal-regulated protein kinase (ERK) mitogen-activated protein kinases and Phosphatidylinositol 3โ€“kinase in the regulation of Mcl-1 โ€ฆ
  1174. โ€ฆ vascular endothelial cells by a phosphatase inhibitor: possible involvement of extracellular signal-regulated kinase and Phosphatidylinositol 3โ€“kinase
  1175. Growth hormone exerts antiapoptotic and proliferative effects through two different pathways involving nuclear factor-ฮบB and Phosphatidylinositol 3โ€“kinase
  1176. Factor VIIa/tissue factor-induced signaling via activation of Src-like kinases, Phosphatidylinositol 3โ€“kinase, and Rac
  1177. โ€ฆ agonists increase expression of glutamate transporter GLT-1 in astrocytes through pathways dependent on Phosphatidylinositol 3โ€“kinase and transcription factor NF โ€ฆ
  1178. Both src-dependent and-independent mechanisms mediate Phosphatidylinositol 3โ€“kinase regulation of colony-stimulating factor 1-activated mitogen-activated protein โ€ฆ
  1179. Regulation of nuclear factor ฮบB transactivation: implication of Phosphatidylinositol 3โ€“kinase and protein kinase C ฮถ in c-Rel activation by tumor necrosis factor ฮฑ
  1180. Phosphatidylinositol 3โ€kinase and the control of endosome dynamics: new players defined by structural motifs
  1181. โ€ฆ of tyrosine residues in vascular endothelial growth factor receptor-2/FLK-1 involved in activation of Phosphatidylinositol 3โ€“kinase and cell proliferation
  1182. Tyr612 and Tyr632 in human insulin receptor substrate-1 are important for full activation of insulin-stimulated Phosphatidylinositol 3โ€“kinase activity and translocation of โ€ฆ
  1183. โ€ฆ of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and Phosphatidylinositol 3โ€“kinase activation
  1184. 1ฮฑ, 25-Dihydroxyvitamin D3-induced monocyte antimycobacterial activity is regulated by Phosphatidylinositol 3โ€“kinase and mediated by the NADPH โ€ฆ
  1185. โ€ฆ effects of morphine in peroxynitrite-induced apoptosis of primary rat neonatal astrocytes: potential involvement of G protein and Phosphatidylinositol 3โ€“kinase (PI3 โ€ฆ
  1186. Phosphatidylinositol 3โ€“kinaseโ€“dependent translocation of phospholipase Cฮณ2 in mouse megakaryocytes is independent of Bruton tyrosine kinase translocation
  1187. Phosphatidylinositol 3โ€“kinase-dependent extracellular calcium influx is essential for CX3CR1-mediated activation of the mitogen-activated protein kinase โ€ฆ
  1188. Up-regulation of endothelial nitric-oxide synthase promoter by the Phosphatidylinositol 3โ€“kinase ฮณ/Janus kinase 2/MEK-1-dependent pathway
  1189. โ€ฆ domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent Phosphatidylinositol 3โ€ฒ-kinase activation and endothelial cell โ€ฆ
  1190. ErbB2-overexpressing human mammary carcinoma cells display an increased requirement for the Phosphatidylinositol 3โ€“kinase signaling pathway in anchorage โ€ฆ
  1191. Regulatory role of Phosphatidylinositol 3โ€“kinase on TNF-ฮฑโ€“Induced cyclooxygenase 2 expression in colonic epithelial cells
  1192. Cytokines prevent dexamethasone-induced apoptosis via the activation of mitogen-activated protein kinase and Phosphatidylinositol 3โ€“kinase pathways in a new โ€ฆ
  1193. The Gab1 docking protein links the b cell antigen receptor to the Phosphatidylinositol 3โ€“kinase/Akt signaling pathway and to the SHP2 tyrosine phosphatase
  1194. Phosphatidylinositol 3โ€“kinase mediates integrin-dependent NF-(ฮบ) B and MAPK activation through separate signaling pathways
  1195. Diversification of cardiac insulin signaling involves the p85ฮฑ/ฮฒ subunits of Phosphatidylinositol 3โ€“kinase
  1196. The expression of the p85ฮฑ subunit of Phosphatidylinositol 3โ€“kinase is induced by activation of the peroxisome proliferator-activated receptor ฮณ in human adipocytes
  1197. Stimulation of human neutrophils by chemotactic factors is associated with the activation of Phosphatidylinositol 3โ€“kinase ฮณ
  1198. Roles of insulin receptor substrate-1, Phosphatidylinositol 3โ€“kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in ฮฒ-cells
  1199. Differential regulation of the Phosphatidylinositol 3โ€“kinase/Akt and p70 S6 kinase pathways by the ฮฑ1A-adrenergic receptor in rat-1 fibroblasts
  1200. Phosphatidylinositol 3โ€“kinase, protein kinase B and ribosomal S6 kinases in the stimulation of thyroid epithelial cell proliferation by cAMP and growth factors in the โ€ฆ
  1201. Src transduces erythropoietin-induced differentiation signals through Phosphatidylinositol 3โ€“kinase
  1202. Glial cell line-derived neurotrophic factor-stimulated Phosphatidylinositol 3โ€“kinase and Akt activities exert opposing effects on the ERK pathway: importance โ€ฆ
  1203. The bile acidโ€“activated Phosphatidylinositol 3โ€“kinase pathway inhibits Fas apoptosis upstream of bid in rodent hepatocytes
  1204. Cross-talk between Phosphatidylinositol 3โ€“kinase and sphingomyelinase pathways as a mechanism for cell survival/death decisions
  1205. Reciprocal regulation of glycogen phosphorylase and glycogen synthase by insulin involving Phosphatidylinositolโ€“3 kinase and protein phosphatase-1 in HepG2 cells
  1206. Stimulation of tetrahydrobiopterin synthesis induced by insulin: possible involvement of Phosphatidylinositol 3โ€“kinase
  1207. Insulin-like growth factor (IGF) binding protein-3 potentiation of IGF action is mediated through the Phosphatidylinositolโ€“3โ€“kinase pathway and is associated with โ€ฆ
  1208. Glut-1 Translocation in FRTL-5 Thyroid Cells: Role of Phosphatidylinositol 3โ€“kinase and N-Glycosylation
  1209. Persistent activation of Phosphatidylinositol 3โ€“kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 โ€ฆ
  1210. Five isoforms of the Phosphatidylinositol 3โ€kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations
  1211. Phosphatidylinositolโ€“3 kinase regulates p21ras activation during IgE-mediated stimulation of human basophils
  1212. Ceramide regulates lipopolysaccharide-induced Phosphatidylinositol 3โ€“kinase and Akt activity in human alveolar macrophages
  1213. Insulin stimulates NHE1 activity by sequential activation of Phosphatidylinositol 3โ€kinase and protein kinase C ฮถ in human erythrocytes
  1214. Evidence for a Functional Association between Phosphatidylinositol 3โ€“kinase and c-src in the Spreading Response of Osteoclasts to Colony-Stimulating Factor-1
  1215. A Specific Role of Phosphatidylinositol 3โ€“kinase ฮณ: A Regulation of Autonomic Ca2+ Oscillations in Cardiac Cells
  1216. Stabilization of cyclin D1 mRNA via the Phosphatidylinositol 3โ€“kinase pathway in MCF-7 human breast cancer cells
  1217. Protein phosphatase 2A and Phosphatidylinositol 3โ€“kinase regulate the activity of Sp1-responsive promoters
  1218. Tyrosine phosphorylation of the p85 subunit of Phosphatidylinositol 3โ€“kinase correlates with high proliferation rates in sublines derived from the Jurkat leukemia
  1219. Constitutively active Phosphatidylinositol 3โ€“kinase and AKT are sufficient to stimulate the epithelial Na+/H+ exchanger 3
  1220. Insulin-like growth factor-1 protects H9c2 cardiac myoblasts from oxidative stress-induced apoptosis via Phosphatidylinositol 3โ€“kinase and extracellular signal โ€ฆ
  1221. โ€ฆ protein phosphatase by insulin in vascular smooth muscle cells: evaluation of the role of Rho kinase and Phosphatidylinositolโ€“3โ€“kinase-dependent signaling pathways
  1222. Phosphatidylinositol 3โ€ฒ-kinase blocks CD95 aggregation and caspase-8 cleavage at the death-inducing signaling complex by modulating lateral diffusion of CD95
  1223. Platelet-derived growth factor activates porcine thecal cell Phosphatidylinositolโ€“3โ€“kinase-Akt/PKB and Ras-extracellular signal-regulated kinase-1/2 kinase signaling โ€ฆ
  1224. Insulin-like growth factor I-induced degradation of insulin receptor substrate 1 is mediated by the 26S proteasome and blocked by Phosphatidylinositol 3โ€ฒ-kinase โ€ฆ
  1225. 15-Deoxy-ฮ”12, 14-prostaglandin J2 and thiazolidinediones activate the MEK/ERK pathway through Phosphatidylinositol 3โ€“kinase in vascular smooth muscle โ€ฆ
  1226. Association of Phosphatidylinositol 3โ€“kinase composed of p110ฮฒ-catalytic and p85-regulatory subunits with the small GTPase Rab5
  1227. Interleukins 4 and 13 increase intestinal epithelial permeability by a Phosphatidylinositol 3โ€“kinase pathway: lack of evidence for STAT 6 involvement
  1228. ERK regulates the hepatocyte growth factor-mediated interaction of Gab1 and the Phosphatidylinositol 3โ€“kinase
  1229. Intracellular signals that control cell proliferation in mammalian balance epithelia: key roles for Phosphatidylinositolโ€“3 kinase, mammalian target of rapamycin, and S6 โ€ฆ
  1230. Cutting edge: gab2 mediates an inhibitory Phosphatidylinositol 3โ€ฒ-kinase pathway in T cell antigen receptor signaling
  1231. Brainโ€derived neurotrophic factor induces excitotoxic sensitivity in cultured embryonic rat spinal motor neurons through activation of the Phosphatidylinositol 3โ€kinase โ€ฆ
  1232. Phosphatidylinositol 3โ€“kinase signaling to Akt mediates survival in isolated canine islets of Langerhans
  1233. โ€ฆ (VEGF) receptor-1 down-modulates VPF/VEGF receptor-2-mediated endothelial cell proliferation, but not migration, through Phosphatidylinositol 3โ€“kinase โ€ฆ
  1234. Involvement of a Phosphatidylinositol 3โ€“kinaseโ€“p38 mitogen activated protein kinase pathway in antigen-induced IL-4 production in mast cells
  1235. โ€ฆ growth factor/scatter factor stimulates migration of rat mammary fibroblasts through both mitogenโ€activated protein kinase and Phosphatidylinositol 3โ€kinase/Akt โ€ฆ
  1236. Nerve Growth Factor Uses Ras/ERK and Phosphatidylinositol 3โ€“kinase Cascades to Up-regulate theN-Methyl-d-aspartate Receptor 1 Promoter
  1237. Glial cell line-derived neurotrophic factor promotes survival and induces differentiation through the Phosphatidylinositol 3โ€“kinase and mitogen-activated protein kinase โ€ฆ
  1238. A Phosphatidylinositol 3โ€“kinase of Candida albicans influences adhesion, filamentous growth and virulence
  1239. A link between insulin resistance and hyperinsulinemia: inhibitors of Phosphatidylinositol 3โ€“kinase augment glucose-induced insulin secretion from islets of lean, but โ€ฆ
  1240. Requirement of Phosphatidylinositol 3โ€“kinase activity for translocation of exogenous aFGF to the cytosol and nucleus
  1241. In vitro hormone induction of final oocyte maturation in striped bass (Morone saxatilis) follicles is inhibited by blockers of Phosphatidylinositol 3โ€“kinase activity
  1242. Tyrosine kinase-dependent, Phosphatidylinositol 3โ€ฒ-kinase, and mitogen-activated protein kinase-independent signaling pathways prevent lung adenocarcinoma โ€ฆ
  1243. โ€ฆ preproinsulin gene expression and nucleartrans-location of pancreatic duodenum homeobox-1 require activation of Phosphatidylinositol 3โ€“kinase but not p38 โ€ฆ
  1244. Activation of Phosphatidylinositol 3โ€kinase by a complex of p59fyn and the receptor tyrosine kinase Xmrk is involved in malignant transformation of pigment cells
  1245. โ€ฆ protein-5 helps accelerate progression to androgen-independence in the human prostate LNCaP tumor model through activation of Phosphatidylinositol 3โ€ฒ-kinase โ€ฆ
  1246. Dual Signaling via Protein kinase C and Phosphatidylinositol 3โ€ฒ-kinase/Akt Contributes to Bradykinin B2Receptor-induced Cardioprotection in Guinea Pig Hearts
  1247. Insulin-like growth factor I potentiates kainate receptors through a Phosphatidylinositol 3โ€“kinase dependent pathway
  1248. Regulation of Id2 gene expression by the insulin-like growth factor I receptor requires signaling by Phosphatidylinositol 3โ€“kinase
  1249. Basic fibroblast growth factor stimulates surface expression and activity of Na+/H+ exchanger NHE3 via mechanism involving Phosphatidylinositol 3โ€“kinase
  1250. Aggretin, a C-type lectin protein, induces platelet aggregation via integrin ฮฑ2ฮฒ1 and GPIb in a Phosphatidylinositol 3โ€“kinase independent pathway
  1251. A molecular basis for T cell suppression by ILโ€10: CD28โ€associated ILโ€10 receptor inhibits CD28 tyrosine phosphorylation and Phosphatidylinositol 3โ€kinase binding
  1252. Regulation of oxidative stress-induced calcium release by Phosphatidylinositol 3โ€“kinase and Brutonโ€™s tyrosine kinase in B cells
  1253. Cyclooxygenase-2 inducing Mcl-1-dependent survival mechanism in human lung adenocarcinoma CL1. 0 cells: involvement of Phosphatidylinositol 3โ€“kinase โ€ฆ
  1254. Impaired muscle glycogen synthase in type 2 diabetes is associated with diminished Phosphatidylinositol 3โ€“kinase activation
  1255. โ€ฆ and luteinizing hormone in cultured porcine granulosa-luteal cells: possible convergence of protein kinase a, Phosphatidylinositol 3โ€“kinase, and mitogen-activated โ€ฆ
  1256. Role of Phosphatidylinositol 3โ€“kinase and specific protein kinase B isoforms in the suppression of apoptosis mediated by the Abelson protein-tyrosine kinase
  1257. The expression of the ฮณ subunit of Na-K-ATPase is regulated by osmolality via C-terminal Jun kinase and Phosphatidylinositol 3โ€“kinase-dependent mechanisms
  1258. Ras activation of Phosphatidylinositol 3โ€“kinase and Akt
  1259. Involvement of Phosphatidylinositol 3โ€“kinase and mitogen-activated protein kinases in glycine-extended gastrin-induced dissociation and migration of gastric โ€ฆ
  1260. Direct interaction between the cytoplasmic tail of ADAM 12 and the Src homology 3 domain of p85ฮฑ activates Phosphatidylinositol 3โ€“kinase in C2C12 cells
  1261. Regulation of epidermal growth factor receptor endocytosis by wortmannin through activation of Rab5 rather than inhibition of Phosphatidylinositol 3โ€“kinase
  1262. The insulin receptor substrate (IRS)-1 recruits Phosphatidylinositol 3โ€“kinase to Ret: evidence for a competition between Shc and IRS-1 for the binding to Ret
  1263. Activation of the Phosphatidylinositol 3โ€“kinase-Akt/protein kinase B signaling pathway in arachidonic acid-stimulated human myeloid and endothelial cells โ€ฆ
  1264. An SH2-domain-containing kinase negatively regulates the Phosphatidylinositolโ€“3 kinase pathway
  1265. The Phosphatidylinositol 3โ€“kinase pathway selectively controls sIL-1RA not interleukin-1ฮฒ production in the septic leukocytes
  1266. T cell activation induces direct binding of the Crk adapter protein to the regulatory subunit of Phosphatidylinositol 3โ€“kinase (p85) via a complex mechanism โ€ฆ
  1267. Involvement of phospholipase D in sphingosine 1-phosphate-induced activation of Phosphatidylinositol 3โ€“kinase and Akt in Chinese hamster ovary cells โ€ฆ
  1268. The T cell antigen receptor activates Phosphatidylinositol 3โ€kinaseโ€regulated serine kinases protein kinase B and ribosomal S6 kinase 1
  1269. Rac and Phosphatidylinositol 3โ€“kinase regulate the protein kinase B in FcฮตRI signaling in RBL 2H3 mast cells
  1270. Activation of Phosphatidylinositol 3 kinase by muscarinic receptors in astrocytoma cells
  1271. โ€ฆ with Thyrotropin-induced G1-S Transition Mediated by cAMP-dependent Protein kinase and Phosphatidylinositol 3โ€“kinase: INVOLVEMENT OF RhoA AND โ€ฆ
  1272. Expression of a constitutively active form of Phosphatidylinositol 3โ€“kinase inhibits the induction of nitric oxide synthase in human astrocytes
  1273. Role of Phosphatidylinositol 3โ€“kinase in anti-IgM-and anti-IgD-induced apoptosis in B cell lymphomas
  1274. Insulin-mediated cell proliferation and survival involve inhibition of c-Jun N-terminal kinases through a Phosphatidylinositol 3โ€“kinase-and mitogen-activated protein โ€ฆ
  1275. Enteric neuroblasts require the Phosphatidylinositol 3โ€kinase pathway for GDNFโ€stimulated proliferation
  1276. The CK2 phosphorylation of vitronectin: Promotion of cell adhesion via the ฮฑvฮฒ3โ€“Phosphatidylinositol 3โ€“kinase pathway
  1277. ฮฒ-Adrenergic stimulation of rat cardiac fibroblasts promotes protein synthesis via the activation of Phosphatidylinositol 3โ€“kinase
  1278. โ€ฆ 1 fusion protein of the t (6; 8) translocation induces cell survival mediated by mitogen-activated protein kinase and Phosphatidylinositol 3โ€“kinase/Akt/mTOR pathways
  1279. Ca2+-and Phosphatidylinositol 3โ€“kinase-dependent nitric oxide generation in lung endothelial cells in situ with ischemia
  1280. Compartmentalization and insulin-induced translocations of insulin receptor substrates, Phosphatidylinositol 3โ€“kinase, and protein kinase B in rat liver
  1281. Sites of action of protein kinase C and Phosphatidylinositol 3โ€“kinase are distinct in oxidized low density lipoprotein-induced macrophage proliferation
  1282. Role of Phosphatidylinositolโ€“3 kinase and its association with Gab1 in thrombopoietin-mediated up-regulation of platelet function
  1283. Heregulinโ€ฮฒ is especially potent in activating Phosphatidylinositol 3โ€kinase in nontransformed human mammary epithelial cells
  1284. Interaction of the insulin receptor ฮฒ-subunit with Phosphatidylinositol 3โ€“kinase in bovine ROS
  1285. ILโ€12 selectively regulates STAT4 via Phosphatidylinositol 3โ€kinase and Rasโ€independent signal transduction pathways
  1286. Phosphatidylinositol 3โ€“kinase stimulates muscle differentiation by activating p38 mitogen-activated protein kinase
  1287. โ€ฆ rendered erythropoietin independent by infection with Friend spleen focus-forming virus show constitutive activation of Phosphatidylinositol 3โ€“kinase and Akt kinase โ€ฆ
  1288. Epidermal growth factor-induced Phosphatidylinositol 3โ€“kinase activation and DNA synthesis: identification of Grb2-associated binder 2 as the major mediator โ€ฆ
  1289. Plateletโ€activating factor activates mitogenโ€activated protein kinases through the activation of Phosphatidylinositol 3โ€kinase and tyrosine kinase in human eosinophils
  1290. Phosphatidylinositol 3โ€“kinase is required for the trophic, but not the survival-promoting, actions of NGF on sympathetic neurons
  1291. HIVโ€1 Tat protein downโ€regulates CREB transcription factor expression in PC12 neuronal cells through a Phosphatidylinositol 3โ€kinase/AKT/cyclic nucleoside โ€ฆ
  1292. LY 294002, an inhibitor of Phosphatidylinositol 3โ€“kinase, inhibits GH-mediated expression of the IGF-I gene in rat hepatocytes
  1293. Hck enhances the adherence of lipopolysaccharide-stimulated macrophages via Cbl and Phosphatidylinositol 3โ€“kinase
  1294. โ€ฆ apoptosis by crystals of calcium pyrophosphate dihydrate is mediated by the extracellular signal-regulated kinase and Phosphatidylinositol 3โ€“kinase/Akt pathways up โ€ฆ
  1295. Phosphatidylinositol 3โ€“kinase confers resistance to encephalomyocarditis and herpes simplex virus-induced cell death through the activation of distinct downstream โ€ฆ
  1296. Regulation of p85ฮฑ Phosphatidylinositolโ€“3โ€“kinase expression by peroxisome proliferator-activated receptors (PPARs) in human muscle cells
  1297. The Rho/Rhoโ€kinase and the Phosphatidylinositol 3โ€kinase pathways are essential for spontaneous locomotion of Walker 256 carcinosarcoma cells
  1298. Interactions between Phosphatidylinositol 3โ€“kinase and nitric oxide: explaining the paradox
  1299. The roles of Phosphatidylinositol 3โ€“kinase and protein kinase Cฮถ for thrombopoietin-induced mitogen-activated protein kinase activation in primary murine โ€ฆ
  1300. Inhibition of Phosphatidylinositolโ€“3 kinase/Akt or mitogen-activated protein kinase signaling sensitizes endothelial cells to TNF-ฮฑ cytotoxicity
  1301. Activation of the Phosphatidylinositol 3โ€“kinase/Akt pathway protects against interleukin-3 starvation but not DNA damage-induced apoptosis
  1302. Enhanced cell killing by overexpression of dominantโ€negative Phosphatidylinositol 3โ€kinase subunit, ฮ”p85, following genotoxic stresses
  1303. โ€ฆ is required for efficient induction of chronic myeloid leukemiaโ€“like disease in mice but not for lymphoid leukemogenesis or activation of Phosphatidylinositol 3โ€“kinase
  1304. Phosphatidylinositol 3โ€“kinase activity regulates ฮฑ-thrombin-stimulated G1 progression by its effect on cyclin D1 expression and cyclin-dependent kinase 4 โ€ฆ
  1305. โ€ฆ promotes the expression of peroxisome proliferator-activated receptor ฮณ in vascular smooth muscle cells by a Phosphatidylinositol 3โ€“kinase/Akt signaling pathway
  1306. Mechanism of Phosphatidylinositol 3โ€“kinase-dependent increases in BAC1. 2F5 macrophage-like cell density in response to M-CSF: Phosphatidylinositol 3โ€“kinase โ€ฆ
  1307. โ€ฆ effect of hepatocyte growth factor and fibronectin in anchorage-independent survival of mammary carcinoma cells: requirement for Phosphatidylinositol 3โ€“kinase โ€ฆ
  1308. Interleukin-6 protects rat PC12 cells from serum deprivation or chemotherapeutic agents through the Phosphatidylinositol 3โ€“kinase and STAT3 pathways
  1309. Phosphatidylinositol 3โ€“kinase and Ras/mitogen-activated protein kinase signaling pathways are required for the regulation of 5-aminolevulinate synthase gene โ€ฆ
  1310. Tyrosine kinase and Phosphatidylinositol 3โ€“kinase activation are required for cyclic adenosine 3โ€ฒ, 5โ€ฒ-monophosphate-dependent potentiation of deoxyribonucleic โ€ฆ
  1311. LFA-1-mediated costimulation of CD8+ T cell proliferation requires Phosphatidylinositol 3โ€“kinase activity
  1312. Phosphatidylinositolโ€“3โ€ฒ kinase-dependent vesicle formation in macrophages in response to macrophage colony stimulating factor
  1313. A Phosphatidylinositol 3โ€kinase of Candida albicans: molecular cloning and characterization
  1314. Tyrosine phosphorylation is involved in Phosphatidylinositol 3โ€“kinase activation in bovine rod outer segments
  1315. Phosphatidylinositol 3โ€“kinase-dependent pathways oppose fas-induced apoptosis and limit chloride secretion in human intestinal epithelial cells: implications โ€ฆ
  1316. Phosphatidylinositol 3โ€kinase activity is required for the expression of glial fibrillary acidic protein upon cAMPโ€dependent induction of differentiation in rat C6 glioma
  1317. Phosphatidylinositol 3โ€“kinase in cumulus cells and oocytes is responsible for activation of oocyte mitogen-activated protein kinase during meiotic progression beyond โ€ฆ
  1318. Neurotrophic factor protection against ethanol toxicity in rat cerebellar granule cell cultures requires Phosphatidylinositol 3โ€“kinase activation
  1319. Phosphatidylinositol 3โ€“kinase activity in murine motoneuron disease: the progressive motor neuropathy mouse
  1320. Phosphatidylinositol 3โ€kinase Translocates to the Nucleus of Osteoblastโ€Like MC3T3โ€E1 Cells in Response to Insulinโ€Like Growth Factor I and Plateletโ€Derived โ€ฆ
  1321. โ€ฆ a combined treatment with epidermal growth factor and transforming growth factor-ฮฒ in rat hepatocytes: role of Phosphatidylinositol 3โ€“kinase-induced AP-1 โ€ฆ
  1322. Phosphatidylinositol 3โ€“kinase is required for adherens junction-dependent mammary epithelial cell spheroid formation
  1323. Role of Phosphatidylinositol 3โ€“kinase in acetylcholine-induced dilatation of rat basilar artery
  1324. โ€ฆ growth factor receptor 1 expressed in Xenopus laevis oocytes after fibroblast growth factor 1 addition: Role of Grb2, Phosphatidylinositol 3โ€kinase, Src tyrosine kinase โ€ฆ
  1325. Effect of long-term caloric restriction on GLUT4, Phosphatidylinositolโ€“3 kinase p85 subunit, and insulin receptor substrate-1 protein levels in rhesus monkey skeletal โ€ฆ
  1326. Phosphatidylinositol 3โ€“kinase inhibitors, Wortmannin or LY294002, inhibited accumulation of p21 protein after ฮณ-irradiation by stabilization of the protein
  1327. Further evidence for the involvement of insulin receptor substrates in epidermal growth factorโ€induced activation of Phosphatidylinositol 3โ€kinase
  1328. Rosiglitazone (BRL 49653) enhances insulin secretory response via Phosphatidylinositol 3โ€“kinase pathway
  1329. Anchorage-independent activation of mitogen-activated protein kinase through Phosphatidylinositolโ€“3 kinase by insulin-like growth factor I
  1330. Regulation of gene expression during severe caloric restriction: lack of induction of p85alpha Phosphatidylinositol 3โ€“kinase mRNA in skeletal muscle of patients with โ€ฆ
  1331. Tyrosine phosphorylation of the catalytic subunit p110 of Phosphatidylinositolโ€“3 kinase induced by HMG-CoA reductase inhibitor inhibits its kinase activity in โ€ฆ
  1332. Hepatocyte growth factor-induced differential activation of phospholipase Cฮณ1 and Phosphatidylinositol 3โ€“kinase is regulated by tyrosine phosphatase SHP-1 โ€ฆ
  1333. MIP-1ฮฑ induces activation of Phosphatidylinositolโ€“3 kinase that associates with Pyk-2 and is necessary for B-cell migration
  1334. Phosphatidylinositolโ€“3โ€“kinase activation and atypical protein kinase C ฮถ phosphorylation characterize the DMSO signalling in erythroleukemia cells
  1335. Inhibition of Phosphatidylinositol 3โ€“kinase and protein kinase C attenuates extracellular matrix protein-induced vascular smooth muscle cell chemotaxis
  1336. Phosphatidylinositol 3โ€kinase inhibitors prevent mouse cytotoxic Tโ€cell development in vitro
  1337. Phosphatidylinositol 3โ€ฒ-kinase-mediated calcium mobilization regulates chemotaxis in phosphatidic acid-stimulated human neutrophils
  1338. Membrane depolarization-mediated survival of sympathetic neurons occurs through both Phosphatidylinositol 3โ€“kinase-and CaM kinase II-dependent pathways
  1339. Involvement of insulin receptor substrates in epidermal growth factor induced activation of Phosphatidylinositol 3โ€kinase in rat hepatocyte primary culture
  1340. Surfactant protein A regulates pulmonary surfactant secretion via activation of Phosphatidylinositol 3โ€“kinase in type II alveolar cells
  1341. Subcellular localization of insulin receptor substrate family proteins associated with Phosphatidylinositol 3โ€“kinase activity and alterations in lipolysis in primary mouse โ€ฆ
  1342. Phosphatidylinositol 3โ€“kinase in zymosan-and bacteria-induced signalling to mobilisation of arachidonic acid in macrophages
  1343. A human class II MHCโ€“derived peptide antagonizes Phosphatidylinositol 3โ€“kinase to block IL-2 signaling
  1344. Induction of Phosphatidylinositol 3โ€“kinase and serine-threonine kinase-like immunoreactivity in rabbit spinal cord after transient ischemia
  1345. Phosphorylation of unnatural Phosphatidylinositols with Phosphatidylinositol 3โ€“kinase
  1346. Hepatic glutamine transporter activation in burn injury: role of amino acids and Phosphatidylinositolโ€“3โ€“kinase
  1347. VCAM-1 activates Phosphatidylinositol 3โ€“kinase and induces p120Cbl phosphorylation in human airway smooth muscle cells
  1348. Inhibition of Phosphatidylinositol 3โ€“kinase or Mitogen-Activated Protein kinase kinase Leads to Suppression of p34cdc2 kinase Activity and Meiotic Progression โ€ฆ
  1349. DNA Damage-Induced G1 Arrest in Hematopoietic Cells Is Overridden following Phosphatidylinositol 3โ€“kinase-Dependent Activation of Cyclin-Dependent kinase 2
  1350. Phosphatidylinositol 3โ€“kinase and trypsin activation in pancreatitis
  1351. Expression of a prenylation-deficient Rab4 inhibits the GLUT4 translocation induced by active Phosphatidylinositol 3โ€“kinase and protein kinase B
  1352. โ€ฆ induction of tissue inhibitors of metalloproteinase-1 expression and secretion is mediated by mitogen-activated protein kinase and Phosphatidylinositol 3โ€“kinase โ€ฆ
  1353. Interaction of oestrogen receptor with the regulatory subunit of Phosphatidylinositolโ€“3-OH kinase
  1354. A direct interaction between oncogenic Ha-Ras and Phosphatidylinositol 3โ€“kinase is not required for Ha-Ras-dependent transformation of epithelial cells
  1355. โ€ฆ IV Collagen Interacts with a Novel Binding Site on the ฮฒ3Subunit of Integrin ฮฑvฮฒ3 and Stimulates Focal Adhesion kinase and Phosphatidylinositol 3โ€“kinase โ€ฆ
  1356. โ€ฆ 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated aryl hydrocarbon receptor transformation and CYP1A1 induction by the Phosphatidylinositol 3โ€“kinase inhibitor 2-(4 โ€ฆ
  1357. The protein-tyrosine kinase fer associates with signaling complexes containing insulin receptor substrate-1 and Phosphatidylinositol 3โ€“kinase
  1358. Regulation of human neutrophilโ€mediated cartilage proteoglycan degradation by Phosphatidylinositolโ€3โ€kinase
  1359. โ€ฆ of the C/EBP homologous protein (CHOP) by amino acid deprivation requires insulin-like growth factor I, Phosphatidylinositol 3โ€“kinase, and mammalian target of โ€ฆ
  1360. Modulation of the basal activity of Phosphatidylinositolโ€“3โ€“kinase/protein kinase B signaling pathway in human hepatocarcinoma cells.
  1361. Cytokine-stimulated T cells induce macrophage IL-10 production dependent on Phosphatidylinositol 3โ€“kinase and p70S6K: implications for rheumatoid โ€ฆ
  1362. Phosphatidylinositol 3โ€“kinase in bovine lens and its stimulation by insulin and IGF-1
  1363. Insulin activation of mitogen-activated protein (MAP) kinase and Akt is Phosphatidylinositol 3โ€“kinase-dependent in rat adipocytes
  1364. Inhibition of basophil histamine release by tyrosine kinase and Phosphatidylinositol 3โ€“kinase inhibitors
  1365. Stimulation of glycogen synthesis by insulin requires S6 kinase and Phosphatidylinositolโ€3โ€kinase in HTCโ€IR cells
  1366. Thrombinโ€stimulated Phosphatidylinositol 3โ€kinase activity in platelets is associated with activation of PYK2 tyrosine kinase: activation of both enzymes is aggregation โ€ฆ
  1367. HIV-Nef enhances interleukin-2 production and Phosphatidylinositol 3โ€“kinase activity in a human T cell line
  1368. Exercise training prevents maturation-induced decreases in insulin receptor substrate-1 and Phosphatidylinositol 3โ€“kinase in rat skeletal muscle
  1369. Involvement of both Phosphatidylinositol 3โ€“kinase and p44/p42 mitogen-activated protein kinase pathways in the short-term regulation of pyruvate kinase L by insulin
  1370. Induction of Akt phosphorylation in rat primary astrocytes by H2O2 occurs upstream of Phosphatidylinositol 3โ€“kinase: no evidence for oxidative inhibition of PTEN
  1371. Gene encoding the catalytic subunit p110beta of human Phosphatidylinositol 3โ€“kinase: cloning, genomic structure, and screening for variants in patients with type 2 โ€ฆ
  1372. CD19 signal transduction in normal human B cells: linkage to downstream pathways requires Phosphatidylinositol 3โ€kinase, protein kinase C and Ca2+
  1373. Activation of Phosphatidylinositol 3โ€“kinase by oxidative stress leads to the induction of microsomal epoxide hydrolase in H4IIE cells
  1374. Direct identification of a major autophosphorylation site on vascular endothelial growth factor receptor Flt-1 that mediates Phosphatidylinositol 3โ€ฒ-kinase binding
  1375. Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and Phosphatidylinositolโ€“3-OH kinase
  1376. Phosphatidylinositol 3โ€“kinase and protein kinase C contribute to the inhibition by interleukin 6 of phosphoenolpyruvate carboxykinase gene expression in cultured rat โ€ฆ
  1377. Protein tyrosine kinaseโ€dependent regulation of adenylate cyclase and Phosphatidylinositol 3โ€kinase activates the expression of glial fibrillary acidic protein upon โ€ฆ
  1378. Odor-stimulated Phosphatidylinositol 3โ€“kinase in lobster olfactory receptor cells
  1379. 3-Deoxy-3-substituted-D-myo-inositol imidazolyl ether lipid phosphates and carbonate as inhibitors of the Phosphatidylinositol 3โ€“kinase pathway and cancer cell โ€ฆ
  1380. IL-10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate-2 and Phosphatidylinositol 3โ€ฒ-kinase
  1381. Roles of Phosphatidylinositol 3โ€kinase and phospholipase D in temporal activation of superoxide production in FMLPโ€stimulated human neutrophils
  1382. Association of Phosphatidylinositol 3โ€“kinase with the insulin receptor: compartmentation in rat liver
  1383. Prolactin signaling to pim-1 expression: a role for Phosphatidylinositol 3โ€“kinase
  1384. IGF-I stimulates chemotaxis of human neuroblasts. Involvement of type 1 IGF receptor, IGF binding proteins, Phosphatidylinositolโ€“3 kinase pathway and plasmin โ€ฆ
  1385. Interleukinโ€10 and interleukinโ€13 inhibit proinflammatory cytokineโ€induced ceramide production through the activation of Phosphatidylinositol 3โ€kinase
  1386. Eicosanoid 12 (S)-HETE activates Phosphatidylinositol 3โ€“kinase
  1387. โ€ฆ receptor (CR2, CD21) on human B lymphocyte surface triggers tyrosine phosphorylation of the 95-kDa nucleolin and its interaction with Phosphatidylinositol 3 kinase
  1388. Expression of Phosphatidylinositolโ€“3 kinase in lung cancer
  1389. Ca2+-evoked serotonin secretion by parafollicular cells: roles in signal transduction of Phosphatidylinositol 3โ€ฒ-kinase, and the ฮณ and ฮถ isoforms of protein kinase C
  1390. Activation of Phosphatidylinositol 3โ€“kinase is required for transcriptional activity of F-type 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase: assessment of the โ€ฆ
  1391. Dynamin inhibits Phosphatidylinositol 3โ€“kinase in hematopoietic cells
  1392. Evidence for the involvement of Phosphatidylinositol 3โ€“kinase in fMLP-stimulated neutrophil adhesion to ICAM-1-transfected cells
  1393. CRKII participation in the cellular effects of growth hormone and insulin-like growth factor-1: Phosphatidylinositolโ€“3 kinase dependent and independent effects
  1394. โ€ฆ library to identify basic residues in A-Raf required to mediate binding to the Src homology 2 domains of the p85 subunit of Phosphatidylinositol 3โ€ฒ-kinase
  1395. Structural organization of the mouse Phosphatidylinositol 3โ€“kinase p110d gene
  1396. Involvement of tyrosine kinase and Phosphatidylinositol 3โ€“kinase in phagocytosis by ascidian hemocytes
  1397. Phosphatidylinositol 3โ€“kinase modulates IL-18-induced nuclear factor-kappa B activation.
  1398. โ€ฆ -induced glucose transport pathway in 3T3-L1 adipocytes is mediated by gab-1 and requires Gab-1-associated Phosphatidylinositol 3โ€“kinase activity for full โ€ฆ
  1399. Protein kinase C and Phosphatidylinositol 3โ€“kinase independently contribute to P-glycoprotein-mediated drug secretion in the mouse proximal tubule
  1400. Activation of NF-ฮบB binding in HT-29 colon cancer cells by inhibition of Phosphatidylinositol 3โ€“kinase
  1401. Involvement of sphingomyelinase in insulinโ€induced Phosphatidylinositol 3โ€kinase activation
  1402. Mitogenic signaling by cyclic adenosine monophosphate in chromaffin cells involves Phosphatidylinositol 3โ€kinase activation
  1403. โ€ฆ induces eukaryotic initiation factor 4E-binding protein 1 phosphorylation via a Ca2+-dependent pathway independent of Phosphatidylinositol 3โ€“kinase/Akt
  1404. โ€ฆ cascades initiated by fibroblast growth factor 1 on Xenopus oocytes expressing MDA-MB-231 mRNAs: role of Grb2, Phosphatidylinositol 3โ€“kinase, Src tyrosine kinase โ€ฆ
  1405. Activation of phospholipase D in porcine tracheal smooth muscle: role of Phosphatidylinositol 3โ€“kinase and RhoA activation
  1406. Role of the conserved acidic residue Asp21 in the structure of Phosphatidylinositol 3โ€“kinase Src homology 3 domain: circular dichroism and nuclear magnetic โ€ฆ
  1407. Inhibition of Phosphatidylinositol 3โ€“kinase does not alter forskolin-stimulated Clโˆ’ secretion by T84 cells
  1408. Modulation of the basal activity of N-acetylglucosaminyltransferase V by Phosphatidylinositolโ€“3โ€“kinase/protein kinase B signaling pathway in human hepatocarcinoma โ€ฆ
  1409. โ€ฆ of IGF-I on type 2 nitric oxide synthase expression in Ins-1 cells and protection against activation-dependent apoptosis: involvement of Phosphatidylinositol 3โ€“kinase.
  1410. Regulation of the very late antigenโ€4โ€mediated adhesive activity of normal and nonreleaser basophils: roles for Src, Syk, and Phosphatidylinositol 3โ€kinase
  1411. Phosphatidylinositol 3โ€“kinase and prostaglandylinositol cyclic phosphate (cyclic PIP), a mediator of insulin action, in the signal transduction of insulin
  1412. Association of impaired Phosphatidylinositol 3โ€“kinase activity in GLUT1-containing vesicles with malinsertion of glucose transporters into the plasma membrane of โ€ฆ
  1413. Interactions of Phosphatidylinositol 3โ€kinase Src homology 3 domain with its ligand peptide studied by absorption, circular dichroism, and UV resonance Raman โ€ฆ
  1414. Cardiac insulin resistance is associated with an impaired recruitment of Phosphatidylinositol 3โ€“kinase to GLUT4 vesicles.
  1415. Glucosamine enhances platelet-derived growth factor-induced DNA synthesis via Phosphatidylinositol 3โ€“kinase pathway in rat aortic smooth muscle cells
  1416. Phosphatidylinositolโ€3โ€OH kinase regulatory subunits are differentially expressed during development of the rat cerebellum
  1417. Grb-2-Associated Binder-1 Is Involved in Insulin-Induced egr-1 Gene Expression through its Phosphatidylinositol 3โ€ฒ-kinase Binding Site
  1418. Identification of tyrosine residues involved in ligand recognition by the Phosphatidylinositol 3โ€“kinase Src homology 3 domain: Circular dichroism and UV resonance โ€ฆ
  1419. Sensitizing effect of the Phosphatidylinositol 3โ€“kinase inhibitor wortmannin on thermal neutron irradiation with or without boron compound.
  1420. Interleukin-1ฮฒ Induced Synthesis of Protein kinase C-ฮด and Protein kinase C-ฮต in EL4 Thymoma Cells: Possible Involvement of Phosphatidylinositol 3โ€“kinase
  1421. In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires Phosphatidylinositolโ€“3-OH-kinase-dependent and mitogen-activated โ€ฆ
  1422. Ultrastructural modifications and Phosphatidylinositolโ€“3โ€“kinase expression and activity in myocardial tissue deriving from rats in different experimental conditions
  1423. Troglitazone Enhances Glucose Uptake Induced By ฮฑโ€Adrenoceptor Stimulation Via Phosphatidylinositol 3โ€kinase In Rat Heart
  1424. Involvement of regulating the Phosphatidylinositol 3โ€“kinase signaling pathway in the process of herbimycin A-induced erythroid cell differentiation in the K562 โ€ฆ
  1425. Phosphatidylinositol 3โ€“kinase regulates proliferation of RAW 264.7 macrophages
  1426. Regulation of cellular differentiation and cellular function by Phosphatidylinositol 3โ€“kinase
  1427. Up-regulation of Phosphatidylinositolโ€“3 kinase Signaling in plcg1 Gene Null Fibroblasts.
  1428. Tumor Necrosis Factor-ฮฑ, Sphingomyelinase and Ceramides Activate Tyrosine kinase, P21ras and Phosphatidylinositol 3โ€“kinase: Implications for Glucose Transport โ€ฆ
  1429. Arginine-specific ADP-ribosyltransferase on the surface of gizzard smooth muscle cells and the involvement of Phosphatidylinositol 3โ€“kinase in maintaining the activity โ€ฆ
  1430. Casein kinase I associates with members of the centaurin-ฮฑ family of Phosphatidylinositol 3, 4, 5-trisphosphate-binding proteins
  1431. Glucose-induced insulin resistance of Phosphatidylinositol 3โ€ฒ-OH kinase and AKT/PKB is mediated by the hexosamine biosynthesis pathway
  1432. TPO regulates Bcl-xL gene expression through Stat5 and Phosphatidylinositolโ€“3โ€“kinase activation pathways
  1433. Wortmannin, A Specific Phosphatidylinositol 3โ€“kinase Inhibitor, Blocks In Vitro Fertilization and Embryonic Development of Bovine Oocytes Matured In Vitro with โ€ฆ
  1434. Activation of Phosphatidylinositol 3โ€“kinase (PI3K) as a predictor of clinical outcome in breast cancer patients
  1435. Phosphatidylinositol 3โ€“kinase and NF
  1436. The cloning and functional characterisation of murine Phosphatidylinositol 3โ€“kinase gamma
  1437. Phosphatidylinositol 3โ€“kinase is involved in IL-18-stimulated AP-1 activation
  1438. Investigation of Phosphatidylinositolโ€“3โ€“kinase (PI3K) and extracellular signal-regulated kinase 1/2 (ERK1/2) activation
  1439. A novel mechanism of regulation of Phosphatidylinositol 3โ€“kinase: Tyrosine phosphorylation of p85 residue 688
  1440. A Role of Phosphatidylinositol 3โ€“kinase (PI3K) on H-ras-lnduced Invasive phenotype
  1441. The role and regulation of Phosphatidylinositolโ€“3 kinase, PTEN, and AKT in tumorigenesis
  1442. Rac and Phosphatidylinositol 3โ€“kinase
  1443. A Role of Phosphatidylinositol 3โ€“kinase (PI3K) on H-ras-Induced Invasive phenotype
  1444. The relationship of Met326Ile variant of p85? regulatory subunit of Phosphatidylinositol 3โ€“kinase (PI3-K) with type 2 diabetes
  1445. Phosphatidylinositol 3-OH kinaseโ€“Akt/protein kinase B pathway mediates Gas6 induction of scavenger receptor a in immortalized human vascular smooth muscle cell โ€ฆ
  1446. Activation of Phosphatidylinositol 3โ€“kinase (PI3K) is Required for Invasiveness and Motility in H-ras MCE10A Cells
  1447. The Role of Nuclear Factor kB and Phosphatidylinositol 3โ€“kinase in Trypsinogen Activation in Cerulein-Stimulated Rat Pancreatic Acini
  1448. Phosphatidylinositol 3โ€“kinase BUT NOT TUBERIN IS REQUIRED FOR PDGF-INDUCED CELL MIGRATION
  1449. THE ESSENTIAL ROLE OF Phosphatidylinositol 3โ€“kinase IN THE INDUCTION OF MICROSOMAL EPOXIDE HYDROLASE
  1450. Role of Conserved Acidic Residue Asp21 in the Structure of Phosphatidylinositol 3โ€“kinase Src Homology 3 Domain: Circular Dichroism and Nuclear Magnetic โ€ฆ
  1451. Retinoic acid inhibits transformation by modulating Phosphatidylinositol 3โ€“kinase signaling to the nucleus
  1452. Regulation of hematopoietic cell proliferation by cytokine-activated Phosphatidylinositol 3โ€“kinase
  1453. Involvement of Phosphatidylinositol 3โ€“kinase in the Insulin Signaling in Preimplantation Mouse Embryos
  1454. Regulation of FRTL-5 thyroid cell growth by Phosphatidylinositol (OH) 3 kinase-dependent Akt-mediated signaling
  1455. Expression of Phosphatidylinositol 3โ€“kinase during the proliferation of the hypoxic rat pulmonary arterial smooth muscle cells
  1456. Regulation of lysosomal pH in macrophages via Phosphatidylinositol 3โ€“kinase and protein kinase C
  1457. Activation of Phosphatidylinositol 3โ€“kinase-protein kinase B (PI3K-PKB) induced by 17?-estradiol in endometrial carcinoma cell (Ishikawa)
  1458. Cytokines Prevent Dexamethasone-induced Apoptosis via the Activation of Mitogen-activated Protein kinase and Phosphatidylinositol 3โ€“kinase Pathways in a โ€ฆ
  1459. An Inhibitory Role of the Phosphatidylinositol 3โ€“kinase-signaling Pathway in Vascular Endothelial Growth Factor-induced Tissue Factor Expression
  1460. c-CBL is the bridge molecule linking BCR/ABL to Phosphatidylinositolโ€“3 kinase
  1461. Fas and ceramide inhibition of the Phosphatidylinositolโ€“3โ€“kinase (PI3K) cell survival pathway in human granulosa luteal cells (hGLC).
  1462. The Link between Insulin Resistance and Hyperinsulinemia: Inhibition of Phosphatidylinositol 3โ€“kinase (PI3K) by Wortmannin Augments Glucose (G)-Induced Insulin โ€ฆ
  1463. Wortmannin, A Specific Phosphatidylinositol 3โ€“kinase Inhibitor, Blocks In Vitro Fertilization and Embryonic Development of Bovine Oocytes Matured In Vitro with โ€ฆ
  1464. Lysophosphatidylcholine generates superoxide anions through activation of Phosphatidylinositol 3โ€“kinase in human neutrophils
  1465. Coincident signaling of cAMP with Phosphatidylinositol 3โ€˜kinase and mitogen-activated protein kinase signal transduction cascades: A role in regulating gene โ€ฆ
  1466. The role of nucleoside diphosphate kinase and Phosphatidylinositol 3โ€“kinase in the expression and cellular localization of the glial fibrillary acidic protein โ€ฆ
  1467. Insulin Regulates Alternative Splicing of Protein kinase C รŸII through a Phosphatidylinositol 3โ€“kinase-dependent Pathway Involving the Nuclear Serine โ€ฆ
  1468. Evidence for Involvement of Gab-1 Associated Phosphatidylinositol 3โ€“kinase in Osmotic Shock Induced Glucose Transport in 3T3-L1 Adipocytes
  1469. Human SMG-1, a novel Phosphatidylinositol 3โ€“kinase-related protein kinase, associates with components of the mRNA surveillance complex and involved in the โ€ฆ
  1470. Aggretin, a C-Type Lectin Protein, Induces Platelet Aggregation Via Integrin 21 and Gpib in a Phosphatidylinositol 3โ€“kinase Independent Pathway
  1471. Interleukin-1 receptor associated kinase 1 and Phosphatidylinositol 3 kinase regulate the NF-kappaB activation induced by IL-1
  1472. AtPIP5K1, an Arabidopsis thaliana Phosphatidylinositol phosphate kinase, synthesizes PtdIns (3, 4) P2 and PtdIns (4, 5) P2 in vitro and is inhibited by phosphorylation
  1473. Role of the Phosphatidylinositol (PI) 3โ€“kinase/Akt protein kinase signaling pathway in the survival of rat sympathetic neurons
  1474. The Phosphatidylinositol 3โ€“kinaseโ€“AKT pathway in human cancer
  1475. Leading the way: directional sensing through Phosphatidylinositol 3โ€“kinase and other signaling pathways
  1476. Prostanoid receptors and Phosphatidylinositol 3โ€“kinase: a pathway to cancer?
  1477. Analysis of the Phosphatidylinositol 3โ€ฒ-kinase Signaling Pathway in Glioblastoma Patients in Vivo
  1478. A crucial role for the p110ฮด subunit of Phosphatidylinositol 3โ€“kinase in B cell development and activation
  1479. Phosphatidylinositolโ€“3 kinase inhibitors enhance the anti-leukemia effect of STI571
  1480. The Phosphatidylinositol 3โ€“kinase, p38, and extracellular signal-regulated kinase pathways are involved in osteoclast differentiation
  1481. Rapid accumulation of Akt in mitochondria following Phosphatidylinositol 3โ€kinase activation
  1482. Inhibition of Phosphatidylinositol 3โ€“kinase enhances mitogenic actions of insulin in endothelial cells
  1483. The Phosphatidylinositol 3โ€“kinase (PI3K)-Akt pathway suppresses Bax translocation to mitochondria
  1484. Role of the Phosphatidylinositol 3โ€“kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma
  1485. Role of the Phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharide
  1486. Anti-cancer alkyl-lysophospholipids inhibit the Phosphatidylinositol 3โ€“kinaseโ€“Akt/PKB survival pathway
  1487. The Phosphatidylinositol 3โ€“kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human โ€ฆ
  1488. Inhibition of Phosphatidylinositol 3โ€ฒ-kinase Increases Efficacy of Paclitaxel in in Vitro and in Vivo Ovarian Cancer Models
  1489. Phosphatidylinositol 3โ€“kinase/Akt signaling in the response of vascular endothelium to ionizing radiation
  1490. Role of the Phosphatidylinositol 3โ€ฒ-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells
  1491. Receptor-specific regulation of Phosphatidylinositol 3โ€ฒ-kinase activation by the protein tyrosine phosphatase Shp2
  1492. A Phosphatidylinositol 3โ€“kinaseโ€“phosphodiesterase 3Bโ€“cyclic AMP pathway in hypothalamic action of leptin on feeding
  1493. Phosphatidylinositol 3โ€kinase is involved in Tollโ€like receptor 4โ€mediated cytokine expression in mouse macrophages
  1494. Src kinase mediates Phosphatidylinositol 3โ€“kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen
  1495. The role of focal adhesion kinaseโ€“Phosphatidylinositol 3โ€“kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression
  1496. Inhibition of the Phosphatidylinositol 3โ€ฒ-kinase-AKT Pathway Induces Apoptosis in Pancreatic Carcinoma Cells in Vitro and in Vivo
  1497. Phosphatidylinositol 3โ€“kinase mediates proliferative signals in intestinal epithelial cells
  1498. Phosphatidylinositol 3โ€“kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin
  1499. Role of Phosphatidylinositol 3โ€“kinase in oxidative stress-induced disruption of tight junctions
  1500. Targeting the Phosphatidylinositol 3โ€“kinase/Akt pathway for enhancing breast cancer cells to radiotherapy
  1501. Phosphorylation of glycogen synthase kinaseโ€“3ฮฒ during preconditioning through a Phosphatidylinositolโ€“3โ€“kinaseโ€“dependent pathway is cardioprotective
  1502. Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and Phosphatidylinositol 3โ€“kinase
  1503. Human mammary epithelial cell transformation through the activation of Phosphatidylinositol 3โ€“kinase
  1504. Phosphatidylinositol 3โ€“kinase regulates the induction of long-term potentiation through extracellular signal-related kinase-independent mechanisms
  1505. Regulation of hypoxia-inducible factor-1ฮฑ protein level during hypoxic conditions by the Phosphatidylinositol 3โ€“kinase/Akt/glycogen synthase kinase 3ฮฒ โ€ฆ
  1506. Role of translation initiation factor 2B in control of cell survival by the Phosphatidylinositol 3โ€“kinase/Akt/glycogen synthase kinase 3ฮฒ signaling pathway
  1507. Constitutively activated Phosphatidylinositolโ€“3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cฮด
  1508. Activation of the Phosphatidylinositol 3โ€“kinase/protein kinase Akt pathway mediates nitric oxide-induced endothelial cell migration and angiogenesis
  1509. Involvement of protein kinase C and Phosphatidylinositol 3โ€“kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells
  1510. Phosphatidylinositol 3โ€“kinase/Akt stimulates androgen pathway through GSK3ฮฒ inhibition and nuclear ฮฒ-catenin accumulation
  1511. Suppression versus induction of androgen receptor functions by the Phosphatidylinositol 3โ€“kinase/Akt pathway in prostate cancer LNCaP cells with different โ€ฆ
  1512. Mutant epidermal growth factor receptor signaling down-regulates p27 through activation of the Phosphatidylinositol 3โ€“kinase/Akt pathway in glioblastomas
  1513. Normoxic induction of the hypoxia-inducible factor 1ฮฑ by insulin and interleukin-1ฮฒ involves the Phosphatidylinositol 3โ€“kinase pathway
  1514. Effects of deguelin on the Phosphatidylinositol 3โ€“kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells
  1515. Native groupโ€III metabotropic glutamate receptors are coupled to the mitogenโ€activated protein kinase/Phosphatidylinositolโ€3โ€kinase pathways
  1516. โ€ฆ factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and Phosphatidylinositol 3โ€“kinase signaling in colon โ€ฆ
  1517. Phosphatidylinositol 3โ€“kinase Functionally Compartmentalizes the Concurrent Gs Signaling During ฮฒ2-Adrenergic Stimulation
  1518. Modulation of Rab5 and Rab7 recruitment to phagosomes by Phosphatidylinositol 3โ€“kinase
  1519. Immunocytochemical detection of Phosphatidylinositol 3โ€“kinase activation by insulin and leptin
  1520. Activation of Phosphatidylinositol 3โ€“kinase/Akt pathway by androgen through interaction of p85ฮฑ, androgen receptor, and Src
  1521. The endothelial receptor tyrosine kinase Tie1 activates Phosphatidylinositol 3โ€“kinase and Akt to inhibit apoptosis
  1522. Phosphatidylinositol 3โ€“kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination
  1523. Phosphatidylinositol 3โ€“kinase: a molecule mediating BDNF-dependent spatial memory formation
  1524. Phosphatidylinositol 3โ€“kinase regulates nuclear translocation of NF-E2-related factor 2 through actin rearrangement in response to oxidative stress
  1525. Endurance training improves responsiveness to insulin and modulates insulin signal transduction through the Phosphatidylinositol 3โ€“kinase/Akt-1 pathway
  1526. Activation of the Phosphatidylinositol 3โ€“kinase/Akt signaling pathway by retinoic acid is required for neural differentiation of SH-SY5Y human neuroblastoma โ€ฆ
  1527. Inhibition of Phosphatidylinositol 3โ€“kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy
  1528. Src family protein-tyrosine kinases alter the function of PTEN to regulate Phosphatidylinositol 3โ€“kinase/AKT cascades
  1529. Herceptin-induced inhibition of Phosphatidylinositolโ€“3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action
  1530. Microphthalmia associated transcription factor is a target of the Phosphatidylinositolโ€“3โ€“kinase pathway
  1531. Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and Phosphatidylinositolโ€“3 kinase/Akt signaling
  1532. E-cadherin homophilic ligation directly signals through Rac and Phosphatidylinositol 3โ€“kinase to regulate adhesive contacts
  1533. Phosphatidylinositol 3โ€“kinase is required for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CA1 region
  1534. Early expression of myocardial HIF-1ฮฑ in response to mechanical stresses: regulation by stretch-activated channels and the Phosphatidylinositol 3โ€“kinase signaling โ€ฆ
  1535. Phosphatidylinositol 3โ€“kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1ฮฑ nor sufficient for HIF-1-dependent target gene transcription
  1536. Phosphatidylinositol 3โ€“kinase redistribution is associated with skeletal muscle insulin resistance in gestational diabetes mellitus
  1537. Phosphatidylinositol 3โ€kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones
  1538. Genomic copy number analysis of non-small cell lung cancer using array comparative genomic hybridization: implications of the Phosphatidylinositol 3โ€“kinase โ€ฆ
  1539. Requirement of BMP-2-induced Phosphatidylinositol 3โ€“kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene โ€ฆ
  1540. Phosphatidylinositol 3โ€“kinase regulates the CD4/CD8 T cell differentiation ratio
  1541. Endocytosed transferrin receptors recycle via distinct dynamin and Phosphatidylinositol 3โ€“kinase-dependent pathways
  1542. Insulin activation of Phosphatidylinositol 3โ€“kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia
  1543. Regulation of TRAIL expression by the Phosphatidylinositol 3โ€“kinase/Akt/GSK-3 pathway in human colon cancer cells
  1544. RANKL regulates endothelial cell survival through the Phosphatidylinositol 3โ€ฒโ€kinase/Akt signal transduction pathway
  1545. Characterization of the Met326Ile variant of Phosphatidylinositol 3โ€“kinase p85ฮฑ
  1546. Caveolin-induced activation of the Phosphatidylinositol 3โ€“kinase/Akt pathway increases arsenite cytotoxicity
  1547. Protective effect of dopamine D2 agonists in cortical neurons via the Phosphatidylinositol 3 kinase cascade
  1548. Regulation of rat Sertoli cell function by FSH: possible role of Phosphatidylinositol 3โ€“kinase/protein kinase B pathway
  1549. Protective effects of docosahexaenoic acid in staurosporineโ€induced apoptosis: involvement of Phosphatidylinositolโ€3 kinase pathway
  1550. Respiratory syncytial virus inhibits apoptosis and induces NF-ฮบB activity through a Phosphatidylinositol 3โ€“kinase-dependent pathway
  1551. Role of the Phosphatidylinositol 3โ€ฒ-kinase/PTEN/Akt kinase pathway in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in non-small cell โ€ฆ
  1552. Aldosterone regulates vascular reactivity: short-term effects mediated by Phosphatidylinositol 3โ€“kinaseโ€“dependent nitric oxide synthase activation
  1553. ERK negatively regulates the epidermal growth factor-mediated interaction of Gab1 and the Phosphatidylinositol 3โ€“kinase
  1554. Vanadate-induced expression of hypoxia-inducible factor 1ฮฑ and vascular endothelial growth factor through Phosphatidylinositol 3โ€“kinase/Akt pathway and โ€ฆ
  1555. Eph B4 receptor signaling mediates endothelial cell migration and proliferation via the Phosphatidylinositol 3โ€“kinase pathway
  1556. Critical involvement of the Phosphatidylinositol 3โ€“kinase/Akt pathway in anchorage-independent growth and hematogeneous intrahepatic metastasis of liver cancer
  1557. Cannabinoids protect astrocytes from ceramide-induced apoptosis through the Phosphatidylinositol 3โ€“kinase/protein kinase B pathway
  1558. Molecular basis of cell membrane estrogen receptor interaction with Phosphatidylinositol 3โ€“kinase in endothelial cells
  1559. โ€ฆ lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a Phosphatidylinositol 3โ€“kinase/Akt-dependent process
  1560. Kaposiโ€™s sarcoma-associated herpesvirus induces the Phosphatidylinositol 3โ€“kinase-PKC-ฮถ-MEK-ERK signaling pathway in target cells early during infection โ€ฆ
  1561. C5a delays apoptosis of human neutrophils by a Phosphatidylinositol 3โ€“kinase-signaling pathway
  1562. Phosphatidylinositol 3โ€“kinase activity negatively regulates stability of cyclooxygenase 2 mRNA
  1563. CD40 induces human multiple myeloma cell migration via Phosphatidylinositol 3โ€“kinase/AKT/NF-ฮบB signaling
  1564. Ras mediates radioresistance through both Phosphatidylinositol 3โ€“kinase-dependent and Raf-dependent but mitogen-activated protein kinase/extracellular signal โ€ฆ
  1565. ฮฒ1 integrin regulates fibroblast viability during collagen matrix contraction through a Phosphatidylinositol 3โ€“kinase/Akt/protein kinase B signaling pathway
  1566. โ€ฆ growth factor-induced migration of multiple myeloma cells is associated with ฮฒ1 integrin-and Phosphatidylinositol 3โ€“kinase-dependent PKCฮฑ activation
  1567. Activated Gฮฑq inhibits p110ฮฑ Phosphatidylinositol 3โ€“kinase and Akt
  1568. Regulation of Fas expression by STAT3 and c-Jun is mediated by Phosphatidylinositol 3โ€“kinase-AKT signaling
  1569. Ureteric bud outgrowth in response to RET activation is mediated by Phosphatidylinositol 3โ€“kinase
  1570. โ€ฆ tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive Phosphatidylinositol 3โ€ฒ-kinase/Akt pathway signaling
  1571. The role of Phosphatidylinositol 3โ€kinase in neural cell adhesion moleculeโ€mediated neuronal differentiation and survival
  1572. Reduced activation of Phosphatidylinositolโ€“3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle โ€ฆ
  1573. IL-12 provides proliferation and survival signals to murine CD4+ T cells through Phosphatidylinositol 3โ€“kinase/Akt signaling pathway
  1574. Regulation of Phosphatidylinositol 3โ€“kinase activity and Phosphatidylinositol 3, 4, 5-trisphosphate accumulation by neutrophil priming agents
  1575. Implication of Phosphatidylinositol 3โ€“kinase membrane recruitment in hydrogen peroxide-induced activation of PI3K and Akt
  1576. Phosphatidylinositol 3โ€“kinase controls human intestinal epithelial cell differentiation by promoting adherens junction assembly and p38 MAPK activation
  1577. Phosphatidylinositol 3โ€“kinase Regulates Human Immunodeficiency Virus Type 1 Replication following Viral Entry in Primary CD4+ T Lymphocytes and Macrophages
  1578. CD40-dependent activation of Phosphatidylinositol 3โ€“kinase/Akt pathway mediates endothelial cell survival and in vitro angiogenesis
  1579. The phospholipase Cฮณ1-dependent pathway of FcฯตRI-mediated mast cell activation is regulated independently of Phosphatidylinositol 3โ€“kinase
  1580. Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 Phosphatidylinositol 3โ€“kinase
  1581. IKKฮฒ and Phosphatidylinositol 3โ€“kinase/Akt participate in non-pathogenic Gram-negative enteric bacteria-induced RelA phosphorylation and NF-ฮบB activation โ€ฆ
  1582. The Phosphatidylinositol 3โ€kinase inhibitor LY294002 potently blocks Kv currents via a direct mechanism
  1583. Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the Phosphatidylinositol 3โ€“kinase-mediated pathway but โ€ฆ
  1584. โ€ฆ cell motility and nuclear factor ฮบB-mediated secretion of urokinase type plasminogen activator through Phosphatidylinositol 3โ€“kinase/Akt signaling pathways โ€ฆ
  1585. Expression of a mutated form of the p85ฮฑ regulatory subunit of Phosphatidylinositol 3โ€“kinase in a Hodgkinโ€™s lymphoma-derived cell line (CO)
  1586. Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via Phosphatidylinositol 3โ€ฒ-kinase pathway
  1587. โ€ฆ of HER2 by ansamycins induces growth arrest and apoptosis in cells with HER2 overexpression via a HER3, Phosphatidylinositol 3โ€ฒ-kinase-AKT-dependent pathway
  1588. โ€ฆ gene inactivation in mantle cell lymphoma mainly occurs by truncating mutations and missense mutations involving the Phosphatidylinositolโ€“3 kinase domain and is โ€ฆ
  1589. Inactivation of the antiapoptotic Phosphatidylinositol 3โ€“kinase-Akt pathway by the combined treatment of taxol and mitogen-activated protein kinase kinase inhibition
  1590. โ€ฆ -1 protects human breast epithelial cells against intrinsic apoptotic cell death via the focal adhesion kinase/Phosphatidylinositol 3โ€“kinase and MAPK signaling โ€ฆ
  1591. Phosphatidylinositol 3โ€kinase coordinately activates the MEK/ERK and AKT/NFฮบB pathways to maintain osteoclast survival
  1592. Negative regulation of Phosphatidylinositol 3โ€“kinase and Akt signalling pathway by PKC
  1593. The role of Phosphatidylinositol 3โ€“kinase, rho family GTPases, and STAT3 in Ros-induced cell transformation
  1594. Dysregulation of Phosphatidylinositol 3โ€kinase and downstream effectors in human breast cancer
  1595. Insulin down-regulates insulin receptor substrate-2 expression through the Phosphatidylinositol 3โ€“kinase/Akt pathway
  1596. Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and Phosphatidylinositol 3โ€“kinase/AKT by saturated and polyunsaturated โ€ฆ
  1597. Estrogen receptor alpha forms estrogen-dependent multimolecular complexes with insulin-like growth factor receptor and Phosphatidylinositol 3โ€“kinase in the adult rat โ€ฆ
  1598. Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/Phosphatidylinositol 3โ€ฒ-kinase/protein kinase B in prostate โ€ฆ
  1599. A Phosphatidylinositol 3โ€“kinase-independent insulin signaling pathway to N-WASP/Arp2/3/F-actin required for GLUT4 glucose transporter recycling
  1600. Hepatocyte growth factor induced human trophoblast motility involves Phosphatidylinositolโ€“3โ€“kinase, mitogen-activated protein kinase, and inducible nitric oxide โ€ฆ
  1601. Evidence that SHIP-1 contributes to Phosphatidylinositol 3, 4, 5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3โ€“kinase โ€ฆ
  1602. Insulin-like growth factor-I inhibits progesterone receptor expression in breast cancer cells via the Phosphatidylinositol 3โ€“kinase/Akt/mammalian target of rapamycin โ€ฆ
  1603. โ€ฆ hormone-treated astrocytes is mediated by epidermal growth factor/mitogen-activated protein kinaseโ€“Phosphatidylinositol 3โ€“kinase pathways and involves โ€ฆ
  1604. Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of Phosphatidylinositol 3โ€“kinase and Akt activity mediating neuronal survival
  1605. Interaction between Nef and Phosphatidylinositolโ€“3โ€“kinase leads to activation of p21-activated kinase and increased production of HIV
  1606. Potential role of Phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNAโ€“induced immune activation
  1607. p38 Mitogenโ€activated protein kinase and Phosphatidylinositol 3โ€kinase activities have opposite effects on human neutrophil apoptosis
  1608. Activation of Phosphatidylinositol 3โ€“kinase is important for erythropoietin-induced erythropoiesis from CD34+ hematopoietic progenitor cells
  1609. PTEN and Phosphatidylinositol 3โ€ฒ-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: evidence for an effect on the tumor and endothelial โ€ฆ
  1610. Phosphatidylinositol 3โ€“kinase and NF-ฮบB regulate motility of invasive MDA-MB-231 human breast cancer cells by the secretion of urokinase-type plasminogen โ€ฆ
  1611. The Role of Novel Oncogenes Squamous Cell Carcinoma-related Oncogene and Phosphatidylinositol 3โ€“kinase p110ฮฑ in Squamous Cell Carcinoma of the Oral โ€ฆ
  1612. Signal transduction from N-cadherin increases Bcl-2: regulation of the Phosphatidylinositol 3โ€“kinase/Akt pathway by homophilic adhesion and actin โ€ฆ
  1613. Thrombopoietin regulates Bcl-xL gene expression through Stat5 and Phosphatidylinositol 3โ€“kinase activation pathways
  1614. Parallel Phosphatidylinositolโ€“3 kinase and p42/44 mitogen-activated protein kinase signaling pathways subserve the mitogenic and antiapoptotic actions of insulin-like โ€ฆ
  1615. CD28 and inducible costimulatory protein Src homology 2 binding domains show distinct regulation of Phosphatidylinositol 3โ€“kinase, Bcl-xL, and IL-2 expression in โ€ฆ
  1616. TAPP1 and TAPP2 are targets of Phosphatidylinositol 3โ€“kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor
  1617. Evidence that rheumatoid arthritis synovial T cells are similar to cytokineโ€activated T cells: involvement of Phosphatidylinositol 3โ€kinase and nuclear factor ฮบB โ€ฆ
  1618. Epstein-Barr virus latent membrane protein 1 (LMP1) activates the Phosphatidylinositol 3โ€“kinase/Akt pathway to promote cell survival and induce actin filament โ€ฆ
  1619. Ephrin-B2 induces migration of endothelial cells through the Phosphatidylinositolโ€“3 kinase pathway and promotes angiogenesis in adult vasculature
  1620. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated Phosphatidylinositol 3โ€“kinase activity in muscle
  1621. Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of ฮฒ1-integrin and Phosphatidylinositol 3โ€ฒ-kinase/AKT โ€ฆ
  1622. Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-Phosphatidylinositol 3โ€“kinase/Akt signaling pathway by disrupting the association of IRS-1 โ€ฆ
  1623. Synchronous activation of ERK and Phosphatidylinositol 3โ€“kinase pathways is required for collagen and extracellular matrix production in keloids
  1624. EGF receptor mediates adhesion-dependent activation of the Rac GTPase: a role for Phosphatidylinositol 3โ€“kinase and Vav2
  1625. Epidermal growth factor receptor-dependent, NF-ฮบB-independent activation of the Phosphatidylinositol 3โ€“kinase/Akt pathway inhibits ultraviolet irradiation โ€ฆ
  1626. Sustained Production of H2O2Activates Pro-matrix Metalloproteinase-2 through Receptor Tyrosine kinases/Phosphatidylinositol 3โ€“kinase/NF-ฮบB Pathway
  1627. Insulin stimulates hypoxia-inducible factor 1 through a Phosphatidylinositol 3โ€“kinase/target of rapamycin-dependent signaling pathway
  1628. Insulin-like growth factor-I inhibits transcriptional responses of transforming growth factor-ฮฒ by Phosphatidylinositol 3โ€“kinase/Akt-dependent suppression of the โ€ฆ
  1629. โ€ฆ lucidum inhibits spontaneous and Fasโ€mediated apoptosis in human neutrophils through activation of the Phosphatidylinositol 3 kinase/Akt signaling pathway
  1630. Phosphatidylinositol 3 kinase regulates synapse specificity of hippocampal long-term depression
  1631. Phosphatidylinositolโ€“3โ€“kinaseโ€“Akt kinase and p42/p44 mitogen-activated protein kinases mediate neurotrophic and excitoprotective actions of a secreted form of โ€ฆ
  1632. โ€ฆ induces an autocrineโ€paracrine survival pathway via plateletโ€derived growth factor (PDGF)โ€B/PDGFโ€ฮฒ receptor/Phosphatidylinositol 3โ€kinase/Akt signaling in RN46A โ€ฆ
  1633. Characterization of Phosphatidylinositol 3โ€“kinase-dependent phosphorylation of the hydrophobic motif site Thr389 in p70 S6 kinase 1
  1634. Insulin-Like Growth Factor-1โ€“Induced Phosphorylation of Transcription Factor FKHRL1 Is Mediated by Phosphatidylinositol 3โ€“kinase/Akt kinase and Role of This โ€ฆ
  1635. Selective PDZ protein-dependent stimulation of Phosphatidylinositol 3โ€“kinase by the adenovirus E4-ORF1 oncoprotein
  1636. โ€ฆ endothelial growth factor induces protein kinase C (PKC)-dependent Akt/PKB activation and Phosphatidylinositol 3โ€ฒ-kinase-mediated PKCฮด phosphorylation: role of โ€ฆ
  1637. Augmentation of sodium butyrate-induced apoptosis by Phosphatidylinositol 3โ€ฒ-kinase inhibition in the KM20 human colon cancer cell line
  1638. Phosphatidylinositol 3โ€“kinase regulates PMA-induced differentiation and superoxide production in HL-60 cells
  1639. โ€ฆ of FcฯตRIโ€and FcฮณRIโ€mediated degranulation and TNFโ€ฮฑ synthesis in human mast cells: selective utilization of Phosphatidylinositolโ€3โ€kinase for FcฮณRIโ€induced โ€ฆ
  1640. The oncogene Phosphatidylinositol 3โ€ฒ-kinase catalytic subunit ฮฑ promotes angiogenesis via vascular endothelial growth factor in ovarian carcinoma
  1641. Tauroursodeoxycholic acid prevents amyloid-ฮฒ peptide-induced neuronal death via a Phosphatidylinositol 3โ€“kinase-dependent signaling pathway
  1642. Functional cooperation among Ras, STAT5, and Phosphatidylinositol 3โ€“kinase is required for full oncogenic activities of BCR/ABL in K562 cells
  1643. โ€ฆ expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1ฮฑ stabilization: a role for Phosphatidylinositol 3โ€ฒ-kinase
  1644. Involvement of Phosphatidylinositol 3โ€“kinase ฮณ in neutrophil apoptosis
  1645. Activation of Phosphatidylinositol 3โ€“kinase contributes to insulin-like growth factor I-mediated inhibition of pancreatic ฮฒ-cell death
  1646. Inhibition of net HepG2 cell apolipoprotein B secretion by the citrus flavonoid naringenin involves activation of Phosphatidylinositol 3โ€“kinase, independent of insulin โ€ฆ
  1647. The Phosphatidylinositol 3โ€“kinase/Akt signaling pathway modulates the endocrine differentiation of trophoblast cells
  1648. Src and Phosphatidylinositol 3โ€“kinase mediate soluble E-selectinโ€“induced angiogenesis
  1649. Dietary cod protein restores insulin-induced activation of Phosphatidylinositol 3โ€“kinase/Akt and GLUT4 translocation to the T-tubules in skeletal muscle of high-fat-fed โ€ฆ
  1650. Phosphatidylinositol 3โ€“kinase but not tuberin is required for PDGF-induced cell migration
  1651. Inhibition of Phosphatidylinositol 3โ€“kinase sensitizes vascular endothelial cells to cytokine-initiated cathepsin-dependent apoptosis
  1652. The growth arrest-specific gene product Gas6 promotes the survival of human oligodendrocytes via a Phosphatidylinositol 3โ€“kinase-dependent pathway
  1653. Macrophage-colony-stimulating factor-induced activation of extracellular-regulated kinase involves Phosphatidylinositol 3โ€“kinase and reactive oxygen species in โ€ฆ
  1654. The in Vitro and in Vivo Effects of 2-(4-Morpholinyl)-8-phenyl-chromone (LY294002), a Specific Inhibitor of Phosphatidylinositol 3โ€ฒ-kinase, in Human Colon Cancer โ€ฆ
  1655. Essential Role of Phosphatidylinositol 3โ€“kinase-Dependent CCAAT/Enhancer Binding Protein ฮฒ Activation in the Induction of Glutathione S-Transferase by Oltipraz
  1656. Betacellulin induces angiogenesis through activation of mitogenโ€activated protein kinase and Phosphatidylinositol 3โ€˜โ€kinase in endothelial cells
  1657. Oncogenic H-Ras Enhances DNA Repair through the Ras/Phosphatidylinositol 3โ€“kinase/Rac1 Pathway in NIH3T3 Cells: Evidence for association with โ€ฆ
  1658. Evidence for Phosphatidylinositol 3โ€“kinaseโ€”Aktโ€”p70S6K pathway activation and transduction of mitogenic signals by platelet-derived growth factor in human โ€ฆ
  1659. Laminin-10/11 and fibronectin differentially prevent apoptosis induced by serum removal via Phosphatidylinositol 3โ€“kinase/Akt-and MEK1/ERK-dependent โ€ฆ
  1660. The Neuron-Specific Rai (ShcC) Adaptor Protein Inhibits Apoptosis by Coupling Ret to the Phosphatidylinositol 3โ€“kinase/Akt Signaling Pathway
  1661. โ€ฆ expression of early growth response factor-1 by EP4, but not EP2, prostanoid receptors via the Phosphatidylinositol 3โ€“kinase and extracellular signal โ€ฆ
  1662. Phosphatidylinositol 3โ€“kinase Suppresses Glucose-Stimulated Insulin Secretion by Affecting Post-Cytosolic [Ca2+] Elevation Signals
  1663. Requirement for Phosphatidylinositolโ€“3 kinase activity during progression through S-phase and entry into mitosis
  1664. Bile acid depletion and repletion regulate cholangiocyte growth and secretion by a Phosphatidylinositol 3โ€“kinaseโ€“dependent pathway in rats
  1665. The effects of lidocaine on the activity of glutamate transporter EAAT3: the role of protein kinase C and Phosphatidylinositol 3โ€“kinase
  1666. ฮฒ-Arrestin1 mediates insulin-like growth factor 1 (IGF-1) activation of Phosphatidylinositol 3โ€“kinase (PI3K) and anti-apoptosis
  1667. Phosphatidylinositol 3โ€“kinase, protein kinase C, and MEK1/2 kinase regulation of dopamine transporters (DAT) require N-terminal DAT phosphoacceptor sites
  1668. Tumor necrosis factor alpha-induced interleukin-8 production via NF-ฮบB and Phosphatidylinositol 3โ€“kinase/Akt pathways inhibits cell apoptosis in human hepatocytes
  1669. IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and Phosphatidylinositol 3โ€“kinase regulation
  1670. โ€ฆ -cytokine cross-talk: the ELR+ CXC chemokine LIX (CXCl5) amplifies a proinflammatory cytokine response via a Phosphatidylinositol 3โ€“kinase-NF-ฮบB pathway
  1671. Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the Phosphatidylinositol 3โ€“kinase pathway in endothelial โ€ฆ
  1672. Nerve growth factor signals through TrkA, Phosphatidylinositol 3โ€“kinase, and Rac1 to inactivate RhoA during the initiation of neuronal differentiation of PC12 โ€ฆ
  1673. Semaphorin 3F antagonizes neurotrophin-induced Phosphatidylinositol 3โ€“kinase and mitogen-activated protein kinase kinase signaling: a mechanism for growth cone โ€ฆ
  1674. Phosphatidylinositol 3โ€“kinase: a key regulator of vascular tone?
  1675. Estrogen regulation of c-fos gene expression through Phosphatidylinositolโ€“3โ€“kinase-dependent activation of serum response factor in MCF-7 breast cancer cells
  1676. Synapsin I-associated Phosphatidylinositol 3โ€“kinase mediates synaptic vesicle delivery to the readily releasable pool
  1677. Putative Phosphatidylinositol 3โ€“kinase (PI3K) binding motifs in ovine betaretrovirus Env proteins are not essential for rodent fibroblast transformation and PI3K/Akt โ€ฆ
  1678. Phosphatidylinositol 3โ€“kinase is essential for the proliferation of lymphoblastoid cells
  1679. Taurolithocholic acid exerts cholestatic effects via Phosphatidylinositol 3โ€“kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets
  1680. The Phosphatidylinositolโ€3 kinase (PI3K)โ€Akt pathway suppresses neurite branch formation in NGFโ€treated PC12 cells
  1681. Involvement of Phosphatidylinositol 3โ€“kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation
  1682. Interferon beta promotes survival in primary astrocytes through Phosphatidylinositol 3โ€“kinase
  1683. Role of Phosphatidylinositol 3โ€“kinase/Akt pathway in angiotensin II and insulin-like growth factor-1 modulation of nitric oxide synthase in vascular smooth muscle cells
  1684. Acetylcholine leads to free radical production dependent on KATP channels, Gi proteins, Phosphatidylinositol 3โ€“kinase and tyrosine kinase
  1685. Hepatitis B virus X protein activates a survival signaling by linking SRC to Phosphatidylinositol 3โ€“kinase
  1686. โ€ฆ sugar absorption is regulated by phosphorylation and turnover of protein kinase C ฮฒII mediated by Phosphatidylinositol 3โ€“kinase-and mammalian target of โ€ฆ
  1687. The ฮฑ5ฮฒ1 integrin selectively enhances epidermal growth factor signaling to the Phosphatidylinositolโ€“3โ€“kinase/Akt pathway in intestinal epithelial cells
  1688. Src mediates prolactin-dependent proliferation of T47D and MCF7 cells via the activation of focal adhesion kinase/Erk1/2 and Phosphatidylinositol 3โ€“kinase pathways
  1689. Phosphatidylinositol 3โ€“kinase and calcium-activated transcription pathways are required for VLDL-induced smooth muscle cell proliferation
  1690. Estrogen enhances depolarization-induced glutamate release through activation of Phosphatidylinositol 3โ€“kinase and mitogen-activated protein kinase in cultured โ€ฆ
  1691. Regulatory role for SRC and Phosphatidylinositol 3โ€“kinase in initiation of fibronectin matrix assembly
  1692. TC21 mediates transformation and cell survival via activation of Phosphatidylinositol 3โ€“kinase/Akt and NF-ฮบB signaling pathway
  1693. โ€ฆ CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and Phosphatidylinositol 3โ€“kinase signaling leading to โ€ฆ
  1694. Necessary role of Phosphatidylinositol 3โ€kinase in transforming growth factor ฮฒโ€“mediated activation of Akt in normal and rheumatoid arthritis synovial fibroblasts
  1695. โ€ฆ motility and nuclear factor ฮบB-mediated secretion of urokinase type plasminogen activator by inhibiting the Phosphatidylinositol 3โ€ฒ-kinase activity in breast โ€ฆ
  1696. Attenuated 5โ€HT1A receptor signaling in brains of suicide victims: involvement of adenylyl cyclase, Phosphatidylinositol 3โ€kinase, Akt and mitogenโ€activated protein โ€ฆ
  1697. โ€ฆ nitric-oxide synthase by tumor necrosis factor-ฮฑ: a novel pathway involving sequential activation of neutral sphingomyelinase, Phosphatidylinositolโ€“3โ€ฒ kinase, and โ€ฆ
  1698. โ€ฆ cell line via a novel nongenomic mechanism involving the glucocorticoid receptor, protein kinase C, Phosphatidylinositol 3โ€“kinase, and mitogen-activated protein โ€ฆ
  1699. Phosphatidylinositol 3โ€“kinase is a key regulator of early phase differentiation in keratinocytes
  1700. Activation of Protein kinase C-ฮถ by Insulin and Phosphatidylinositolโ€“3,4,5-(PO4)3 Is Defective in Muscle in Type 2 Diabetes and Impaired Glucose Tolerance โ€ฆ
  1701. Evidence that Phosphatidylinositol 3โ€“kinase-and mitogen-activated protein kinase kinase-4/c-Jun NH2-terminal kinase-dependent pathways cooperate to โ€ฆ
  1702. Interleukin-3-mediated cell survival signals include Phosphatidylinositol 3โ€“kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface
  1703. โ€ฆ growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and Phosphatidylinositol 3โ€ฒ-kinase-Akt signaling pathways
  1704. Requirement of Phosphatidylinositol 3โ€“kinase activation and calcium influx for leukotriene B4-induced enzyme release
  1705. Studies of the mitogen-activated protein kinases and Phosphatidylinositolโ€“3 kinase in the lens. 1. The mitogenic and stress responses
  1706. The cross-talk between angiotensin and insulin differentially affects Phosphatidylinositol 3โ€“kinase-and mitogen-activated protein kinase-mediated signaling in rat heart โ€ฆ
  1707. Impaired insulin action on Phosphatidylinositol 3โ€“kinase activity and glucose transport in skeletal muscle of pancreatic cancer patients
  1708. Etk/Bmx transactivates vascular endothelial growth factor 2 and recruits Phosphatidylinositol 3โ€“kinase to mediate the tumor necrosis factor-induced angiogenic โ€ฆ
  1709. Phosphatidylinositol 3โ€ฒ-kinase is required for growth of mast cells expressing the kit catalytic domain mutant
  1710. Cell cycle activation in lung adenocarcinoma cells by the ErbB3/Phosphatidylinositol 3โ€“kinase/Akt pathway
  1711. HIV-1-Tat protein activates Phosphatidylinositol 3โ€“kinase/AKT-dependent survival pathways in Kaposiโ€™s sarcoma cells
  1712. Activation of CR3โ€mediated phagocytosis by MSP requires the RON receptor, tyrosine kinase activity, Phosphatidylinositol 3โ€kinase, and protein kinase C ฮถ
  1713. Insulin activates CCAAT/enhancer binding proteins and proinflammatory gene expression through the Phosphatidylinositol 3โ€“kinase pathway in vascular โ€ฆ
  1714. Insulin inhibits apoptosis of macrophage cell line, THP-1 cells, via Phosphatidylinositolโ€“3โ€“kinaseโ€“dependent pathway
  1715. 1ฮฑ,25-Dihydroxyvitamin D3 Induces Vascular Smooth Muscle Cell Migration via Activation of Phosphatidylinositol 3โ€“kinase
  1716. Phosphatidylinositol 3โ€ฒ-kinase-dependent activation of renal mesangial cell Ki-Ras and ERK by advanced glycation end products
  1717. โ€ฆ -like growth factor-1 receptor activation inhibits oxidized LDL-induced cytochrome C release and apoptosis via the Phosphatidylinositol 3 kinase/Akt signaling pathway
  1718. Phosphatidylinositol 3โ€“kinase controls antineutrophil cytoplasmic antibodiesโ€”induced respiratory burst in human neutrophils
  1719. Follicle-stimulating hormone promotes nuclear exclusion of the forkhead transcription factor FoxO1a via Phosphatidylinositol 3โ€“kinase in porcine granulosa cells
  1720. Role of Phosphatidylinositol 3โ€kinase in neuronal survival and axonal outgrowth of adult mouse dorsal root ganglia explants
  1721. ฮผ-opioid receptor activation prevents apoptosis following serum withdrawal in differentiated SH-SY5Y cells and cortical neurons via Phosphatidylinositol 3โ€“kinase
  1722. Minimal mutation of the cytoplasmic tail inhibits the ability of E-cadherin to activate Rac but not Phosphatidylinositol 3โ€“kinase: direct evidence of a role for โ€ฆ
  1723. Dexamethasone impairs insulin signalling and glucose transport by depletion of insulin receptor substrate-1, Phosphatidylinositol 3โ€“kinase and protein kinase B in โ€ฆ
  1724. Regulation of the Phosphatidylinositol 3โ€“kinase, Akt/protein kinase B, FRAP/mammalian target of rapamycin, and ribosomal S6 kinase 1 signaling pathways โ€ฆ
  1725. The role of Phosphatidylinositol 3โ€ฒ-kinase and its downstream signals in erbB-2-mediated transformation
  1726. Distinct role of Phosphatidylinositol 3โ€“kinase and Rho family GTPases in Vav3-induced cell transformation, cell motility, and morphological changes
  1727. โ€ฆ -like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5โ€ฒ-adenosine monophosphate-dependent protein kinase A-and a Phosphatidylinositol 3โ€“kinase โ€ฆ
  1728. Phosphatidylinositol 3โ€“kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling
  1729. Early stage-specific inhibitions of cardiomyocyte differentiation and expression of Csx/Nkx-2.5 and GATA-4 by Phosphatidylinositol 3โ€“kinase inhibitor LY294002
  1730. Role of the insulin receptor substrate 1 and Phosphatidylinositol 3โ€“kinase signaling pathway in insulin-induced expression of sterol regulatory element binding protein โ€ฆ
  1731. High-fat diet and leptin treatment alter skeletal muscle insulin-stimulated Phosphatidylinositol 3โ€“kinase activity and glucose transport
  1732. โ€ฆ of interferon-ฮณ-inducible GTPase inhibits coxsackievirus B3-induced apoptosis through the activation of the Phosphatidylinositol 3โ€“kinase/Akt pathway and โ€ฆ
  1733. Transformation of mouse fibroblasts by Jaagsiekte sheep retrovirus envelope does not require Phosphatidylinositol 3โ€“kinase
  1734. Y box-binding protein 1 induces resistance to oncogenic transformation by the Phosphatidylinositol 3โ€“kinase pathway
  1735. โ€ฆ growth factor protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a Phosphatidylinositol 3โ€“kinase โ€ฆ
  1736. Phosphatidylinositol 3โ€kinase is essential for kit ligandโ€mediated survival, whereas interleukinโ€3 and flt3 ligand induce expression of antiapoptotic Bclโ€2 family โ€ฆ
  1737. Insulin Resistance, Defective Insulin Receptor Substrate 2โ€”Associated Phosphatidylinositolโ€“3โ€ฒ kinase Activation, and Impaired Atypical Protein kinase C (ฮถ/ฮป) โ€ฆ
  1738. Phosphatidylinositol 3โ€“kinase may mediate isoproterenol-induced vascular relaxation in part through nitric oxide production
  1739. Inhibition of activator protein-1 binding activity and Phosphatidylinositol 3โ€“kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue โ€ฆ
  1740. B cell receptor-mediated Syk-independent activation of Phosphatidylinositol 3โ€“kinase, Ras, and mitogen-activated protein kinase pathways
  1741. High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to Phosphatidylinositol (3, 4, 5)-trisphosphate
  1742. Phosphatidylinositol 3โ€“kinase activity is required for epidermal growth factor to suppress proteolysis
  1743. A new role for the p85-Phosphatidylinositol 3โ€“kinase regulatory subunit linking FRAP to p70 S6 kinase activation
  1744. Phosphatidylinositol 3โ€kinase and extracellular signalโ€regulated kinase are recruited for Fc receptorโ€mediated phagocytosis during monocyteโ€toโ€macrophage โ€ฆ
  1745. Phosphatidylinositol 3โ€“kinase in cumulus cells is responsible for both suppression of spontaneous maturation and induction of gonadotropin-stimulated โ€ฆ
  1746. Inhibition of Phosphatidylinositol 3โ€kinase and p70S6 kinase blocks osteogenic proteinโ€1 induction of alkaline phosphatase activity in fetal rat calvaria cells
  1747. Neuroprotection by scatter factor/hepatocyte growth factor and FGFโ€1 in cerebellar granule neurons is Phosphatidylinositol 3โ€kinase/aktโ€dependent and MAPK/CREB โ€ฆ
  1748. Down-regulation of the Phosphatidylinositol 3โ€“kinase/Akt pathway is involved in retinoic acid-induced phosphorylation, degradation, and transcriptional โ€ฆ
  1749. โ€ฆ -mediated endocytosis and recycling of the neuron-specific Na+/H+ exchanger NHE5 isoform: regulation by Phosphatidylinositol 3โ€ฒ-kinase and the actin โ€ฆ
  1750. Stretch-induced retinal vascular endothelial growth factor expression is mediated by Phosphatidylinositol 3โ€“kinase and protein kinase C (PKC)-ฮถ but not by โ€ฆ
  1751. Antagonism of rat ฮฒ-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and Phosphatidylinositol 3โ€“kinase โ€ฆ
  1752. Inhibition of Phosphatidylinositol 3โ€kinase signaling negates the growth advantage imparted by a mutant epidermal growth factor receptor on human glioblastoma โ€ฆ
  1753. Up-regulation of Phosphatidylinositol 3โ€“kinase and glucose transporter 4 in muscle of rats subjected to maternal undernutrition
  1754. AKT and the Phosphatidylinositol 3โ€“kinase/AKT pathway: important molecular targets for lung cancer prevention and treatment
  1755. Insulin inhibits extracellular regulated kinase 1/2 phosphorylation in a Phosphatidylinositol 3โ€kinase (PI3) kinaseโ€dependent manner in Neuro2a cells
  1756. Vascular endothelial growth factor causes pulmonary vasodilation through activation of the Phosphatidylinositolโ€“3โ€“kinase-nitric oxide pathway in the late โ€ฆ
  1757. Src-Dependent Association of Cas and p85 Phosphatidylinositol 3โ€ฒ-kinase in v-crk-Transformed Cells
  1758. Differential activation of Phosphatidylinositol 3โ€“kinase signaling during proliferation and differentiation of lens epithelial cells
  1759. โ€ฆ -1-Phosphate and Lysophosphatidic Acid Prevent Apoptosis in Osteoblastic Cells via a Signaling Pathway Involving Gi Proteins and Phosphatidylinositolโ€“3 kinase
  1760. Sphingosine-1-phosphate stimulates human glioma cell proliferation through Gi-coupled receptors: Role of ERK MAP kinase and Phosphatidylinositol 3โ€“kinase ฮฒ
  1761. Purinergic P2Y12 receptor blockade inhibits shear-induced platelet Phosphatidylinositol 3โ€“kinase activation
  1762. Adrenomedullin reduces VEGF-induced endothelial adhesion molecules and adhesiveness through a Phosphatidylinositol 3โ€ฒ-kinase pathway
  1763. Fibronectin enhances viability and alters cytoskeletal functions (with effects on the Phosphatidylinositol 3โ€kinase pathway) in small cell lung cancer
  1764. Phosphatidylinositol 3โ€“kinase-dependent, MEK-independent proliferation in response to CaR activation
  1765. Studies of the mitogen-activated protein kinases and Phosphatidylinositolโ€“3 kinase in the lens. 2. The intercommunications
  1766. Lipid rafts as the signaling scaffold for NK cell activation: tyrosine phosphorylation and association of LAT with Phosphatidylinositol 3โ€kinase and phospholipase Cโ€ฮณ โ€ฆ
  1767. Noncatalytic domain of uPA stimulates human extravillous trophoblast migration by using phospholipase C, Phosphatidylinositol 3โ€“kinase and mitogen-activated โ€ฆ
  1768. Co-activation of the Phosphatidylinositolโ€“3โ€“kinase/Akt signaling pathway by N-methyl-D-aspartate and TrkB receptors in cerebellar granule cell neurons
  1769. 1ฮฑ, 25-dihydroxyvitamin D3 stimulates activator protein 1 DNA-binding activity by a Phosphatidylinositol 3โ€“kinase/Ras/MEK/extracellular signal regulated โ€ฆ
  1770. Selenite-induced survival of HuH7 hepatoma cells involves activation of focal adhesion kinaseโ€“Phosphatidylinositol 3โ€“kinase-Akt pathway and Rac1
  1771. Glucose-induced Phosphatidylinositol 3โ€“kinase and mitogen-activated protein kinase-dependent upregulation of the platelet-derived growth factor-ฮฒ receptor โ€ฆ
  1772. Synthetic studies of the Phosphatidylinositol 3โ€“kinase inhibitor LY294002 and related analogues
  1773. โ€ฆ from PC12 Cells by Increasing Ca2+-Responsible Secretory Vesicles through the Activation of Mitogen-Activated Protein kinase and Phosphatidylinositol 3โ€“kinase
  1774. Phosphatidylinositol 3โ€“kinase regulates bone morphogenetic protein-2 (BMP-2)-induced myocyte enhancer factor 2A-dependent transcription of BMP-2 gene โ€ฆ
  1775. โ€ฆ TCRฮณฮด+ and Vฮด2+ TCRฮณฮด+ T lymphocytes from healthy donors and multiple sclerosis patients: Involvement of Phosphatidylinositol 3 kinase and calcium calmodulin โ€ฆ
  1776. Phosphatidylinositol 3โ€“kinase and mek1/2 are necessary for insulin-like growth factor-I-induced vascular endothelial growth factor synthesis in prostate epithelial cells โ€ฆ
  1777. โ€ฆ up-regulated uncoupling protein-1 expression is mediated by insulin receptor substrate 1 through the Phosphatidylinositol 3โ€“kinase/Akt signaling pathway in โ€ฆ
  1778. Pathogenic T cells in murine lupus exhibit spontaneous signaling activity through Phosphatidylinositol 3โ€kinase and mitogenโ€activated protein kinase pathways
  1779. Growth factor receptor-binding protein 10 (Grb10) as a partner of Phosphatidylinositol 3โ€“kinase in metabolic insulin action
  1780. Phosphatidylinositol 3โ€“kinase p85 adaptor function in T-cells: co-stimulation and regulation of cytokine transcription independent of associated p110
  1781. Peroxynitrite activates NF-E2-related factor 2/antioxidant response element through the pathway of Phosphatidylinositol 3โ€“kinase: the role of nitric oxide synthase in rat โ€ฆ
  1782. BMPโ€2 regulates cardiomyocyte contractility in a Phosphatidylinositol 3 kinaseโ€dependent manner
  1783. Phosphatidylinositol 3โ€“kinase in angiotensin II-induced hypertrophy of vascular smooth muscle cells
  1784. Granulocyte-macrophage colony-stimulating factor signals for increased glucose transport via Phosphatidylinositol 3โ€“kinase-and hydrogen peroxide โ€ฆ
  1785. Autocrine signaling through Ras regulates cell survival activity in human glioma cells: potential cross-talk between Ras and the Phosphatidylinositol 3โ€“kinase-Akt โ€ฆ
  1786. Inhibition of the Phosphatidylinositol 3โ€˜-kinase signaling pathway increases the responsiveness of pancreatic carcinoma cells to sulindac
  1787. โ€ฆ factor/scatter factor inhibits UVB-induced apoptosis of human keratinocytes but not of keratinocyte-derived cell lines via the Phosphatidylinositol 3โ€“kinase/AKT โ€ฆ
  1788. Phosphatidylinositol 3โ€˜-kinase and MAPK/ERK kinase 1/2 differentially regulate expression of vascular endothelial growth factor in human malignant astrocytoma cells
  1789. The Phosphatidylinositol 3โ€“kinase inhibitor LY294002 binds the estrogen receptor and inhibits 17ฮฒ-estradiol-induced transcriptional activity of an estrogen sensitive โ€ฆ
  1790. Inhibition of lymphocyte kinase Lck and Phosphatidylinositol 3โ€“kinase by a novel immunosuppressant, lymphostin
  1791. Role of Phosphatidylinositol 3โ€kinase in the binding of Bordetella pertussis to human monocytes
  1792. Human neutrophil-expressed CD28 interacts with macrophage B7 to induce Phosphatidylinositol 3โ€“kinase-dependent IFN-ฮณ secretion and restriction of Leishmania โ€ฆ
  1793. โ€ฆ of a signature of interferon-ฮณ-induced polypeptides that includes manganese-superoxide dismutase and the p85ฮฒ subunit of Phosphatidylinositol 3โ€“kinase
  1794. Decayโ€accelerating factor induction by tumour necrosis factorโ€ฮฑ, through a Phosphatidylinositolโ€3 kinase and protein kinase Cโ€dependent pathway, protects murine โ€ฆ
  1795. Platelet factor 4 inhibits FGF2-induced endothelial cell proliferation via the extracellular signalโ€“regulated kinase pathway but not by the Phosphatidylinositol 3โ€“kinase โ€ฆ
  1796. Targeting of Mitogen-Activated Protein kinases and Phosphatidylinositol 3 kinase Inhibits Hepatocyte Growth Factor/Scatter Factorโ€“Induced Angiogenesis
  1797. Preferential binding of Grb2 or Phosphatidylinositol 3โ€“kinase to the met receptor has opposite effects on HGF-induced myoblast proliferation
  1798. Hypoxia protects human lung microvascular endothelial and epithelial-like cells against oxygen toxicity: role of Phosphatidylinositol 3โ€“kinase
  1799. โ€ฆ in human basophils by p38 mitogenโ€activated protein kinase: phosphorylation is sensitive to the effects of Phosphatidylinositol 3โ€kinase inhibitors and calcium โ€ฆ
  1800. Inhibition of nuclear factor ฮบB and Phosphatidylinositol 3โ€kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor ฮฑ in mice
  1801. โ€ฆ induces intracellular accumulation of multivesicular bodies and major histocompatibility complex class II complexes: potential role of Phosphatidylinositol 3โ€“kinase
  1802. Regulatory role of cAMP on expression of Cdk4 and p27Kip1 by inhibiting Phosphatidylinositol 3โ€“kinase in corneal endothelial cells
  1803. โ€ฆ ) tyrosine kinase phosphorylates and activates phosphoinositide-dependent kinase 1 (PDK1): an alternative Phosphatidylinositol 3โ€“kinase-independent pathway to โ€ฆ
  1804. โ€ฆ acid stimulates DNA synthesis in human microvascular endothelial cells via activation of Jak/STAT and Phosphatidylinositol 3โ€“kinase/Akt signaling, leading to โ€ฆ
  1805. Necessity of tyrosine 719 and Phosphatidylinositol 3โ€ฒ-kinaseโ€“mediated signal pathway in constitutive activation and oncogenic potential of c-kit receptor tyrosine โ€ฆ
  1806. Recruitment of Phosphatidylinositol 3โ€“kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism
  1807. Calcium receptor-induced serotonin secretion by parafollicular cells: role of Phosphatidylinositol 3โ€“kinase-dependent signal transduction pathways
  1808. Motility enhancement by tumor-derived mutant E-cadherin is sensitive to treatment with epidermal growth factor receptor and Phosphatidylinositol 3โ€“kinase inhibitors
  1809. Phosphatidylinositol 3โ€“kinase regulates glycosylPhosphatidylinositol hydrolysis through PLC-ฮณ2 activation in erythropoietin-stimulated cells
  1810. A new class of mutations reveals a novel function for the original Phosphatidylinositol 3โ€“kinase binding site
  1811. Involvement of Phosphatidylinositol 3โ€“kinase in nuclear translocation of protein kinase C ฮถ induced by C2-ceramide in rat hepatocytes
  1812. Enhancement of ischemiaโ€induced tyrosine phosphorylation of Kv1. 2 by vascular endothelial growth factor via activation of Phosphatidylinositol 3โ€kinase
  1813. Involvement of the Src kinase Lyn in phospholipase C-ฮณ2 phosphorylation and Phosphatidylinositol 3โ€“kinase activation in Epo signalling
  1814. โ€ฆ granulocyteโ€“macrophage colonyโ€stimulating factor and interleukinโ€5, inhibits apoptosis of human basophils through Phosphatidylinositol 3โ€kinase: requirement of NF โ€ฆ
  1815. Insulin promotes formation of polymerized microtubules by a Phosphatidylinositol 3โ€“kinase-independent, actin-dependent pathway in 3T3-L1 adipocytes
  1816. โ€ฆ (EPO)-induced erythroid differentiation of K562 cells is accompanied by the nuclear translocation of Phosphatidylinositol 3โ€“kinase and intranuclear generation of โ€ฆ
  1817. Leptin constrains phospholipase C-protein kinase C-induced insulin secretion via a Phosphatidylinositol 3โ€“kinase-dependent pathway
  1818. ฮฒโ€Adrenergic receptorโ€mediated DNA synthesis in neonatal rat cardiac fibroblasts proceeds via a Phosphatidylinositol 3โ€kinase dependent pathway refractory to the โ€ฆ
  1819. Regulation of phospholipase C-ฮณ2 via Phosphatidylinositol 3โ€“kinase in macrophages
  1820. Degradation of IฮบBฮฑ in activated RAW264. 7 cells is blocked by the Phosphatidylinositol 3โ€“kinase inhibitor LY294002
  1821. LY294002, an inhibitor of Phosphatidylinositolโ€“3โ€“kinase, causes preferential induction of apoptosis in human multidrug resistant cells
  1822. Involvement of Phosphatidylinositolโ€“3โ€“kinase in membrane ruffling induced by P-glycoprotein substrates in multidrug-resistant carcinoma cells
  1823. Aspirin protects Caco-2 cells from apoptosis after serum deprivation through the activation of a Phosphatidylinositol 3โ€“kinase/AKT/p21Cip/WAF1pathway
  1824. Lactate-induced translocation of GLUT1 and GLUT4 is not mediated by the Phosphatidylinositolโ€“3โ€“kinase pathway in the rat heart
  1825. Insulinโ€like growth factorโ€1 rescues the mutated FGF receptor 3 (G380R) expressing ATDC5 cells from apoptosis through Phosphatidylinositol 3โ€kinase and MAPK
  1826. Insulin stimulates spreading of skeletal muscle cells involving the activation of focal adhesion kinase, Phosphatidylinositol 3โ€kinase and extracellular signal regulated โ€ฆ
  1827. Binding of Phosphatidylinositol 3, 4, 5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change
  1828. โ€ฆ -regulates the transcription of mouse lon homology ATP-dependent protease through extracellular signal-regulated protein kinase-and Phosphatidylinositolโ€“3โ€“kinase โ€ฆ
  1829. Phosphatidylinositol 3โ€“kinase-like activity in Tetrahymena. Effects of wortmannin and LY 294002
  1830. Involvement of Phosphatidylinositol 3 kinase in the progesterone-induced oocyte maturation in Rana dybowskii
  1831. Growth arrest of PC12 cells by nerve growth factor is dependent on the Phosphatidylinositol 3โ€kinase/Akt pathway via p75 neurotrophin receptor
  1832. โ€ฆ bad and glycogen synthase kinaseโ€“3 in a protein kinase A-dependent manner and prevents apoptosis following inhibition of Phosphatidylinositol 3โ€“kinase
  1833. Wortmannin, a specific inhibitor of Phosphatidylinositolโ€“3โ€“kinase influences neurotrophin-induced spiral ganglion neurite growth
  1834. โ€ฆ -activated receptor gamma impedes Porphyromonas gingivalis lipopolysaccharide interference with salivary mucin synthesis through Phosphatidylinositol 3โ€“kinase โ€ฆ
  1835. External Qi of Yan Xin life science technology can revive or suppress enzyme activity of Phosphatidylinositol 3โ€“kinase
  1836. Matrix-independent activation of Phosphatidylinositol 3โ€“kinase, Stat3, and cyclin A-associated Cdk2 Is essential for anchorage-independent growth of v-Ros โ€ฆ
  1837. Phosphatidylinositol 3โ€“kinase is required for insulin-stimulated tyrosine phosphorylation of Shc in 3T3-L1 adipocytes
  1838. Transient ischemia enhances tyrosine phosphorylation and binding of the NMDA receptor to the Src homology 2 domain of Phosphatidylinositol 3โ€kinase in the rat โ€ฆ
  1839. Kit/stem cell factor receptorโ€induced Phosphatidylinositol 3โ€ฒโ€kinase signalling is not required for normal development and function of interstitial cells of Cajal in โ€ฆ
  1840. Cytoskeletal reorganization induced by insulin: involvement of Grb2/Ash, Ras and Phosphatidylinositol 3โ€kinase signalling
  1841. Selective pharmacological inhibitors reveal the role of Syk tyrosine kinase, phospholipase C, Phosphatidylinositolโ€“3โ€ฒ-kinase, and p38 mitogen-activated protein โ€ฆ
  1842. Phospholipase C and Phosphatidylinositol 3โ€kinase signaling are involved in the exogenous arachidonic acidโ€stimulated respiratory burst in human neutrophils
  1843. Control of proteolysis by norepinephrine and insulin in brown adipocytes: role of ATP, Phosphatidylinositol 3โ€“kinase, and p70 S6K
  1844. โ€ฆ papillomavirus type 1 nucleotide 3225 3โ€ฒ splice site can be rescued in a cell lacking splicing factor ASF/SF2 through activation of the Phosphatidylinositol 3โ€“kinase โ€ฆ
  1845. Gene expression of the p85ฮฑ regulatory subunit of Phosphatidylinositol 3โ€“kinase in skeletal muscle from type 2 diabetic subjects
  1846. Detection of the p110 beta subunit of Phosphatidylinositol 3โ€“kinase complexed with neutral endopeptidase.
  1847. Phosphatidylinositol 3โ€“kinase mediates inhibitory effect of angiotensin II on sodium/glucose cotransporter in renal epithelial cells
  1848. Involvement of signaling through protein kinase C and Phosphatidylinositol 3โ€“kinase in the excystation and metacystic development of Entamoeba invadens
  1849. โ€ฆ of glial cellโ€derived neurotrophic factor and cardiotrophinโ€1 protects PC12 cells from injury: Involvement of the Phosphatidylinositol 3โ€kinase and mitogenโ€activated โ€ฆ
  1850. ฮฑ4 integrin signaling activates Phosphatidylinositol 3โ€“kinase and stimulates T cell adhesion to intercellular adhesion molecule-1 to a similar extent as CD3, but โ€ฆ
  1851. Prolongation of insulin-induced activation of mitogen-activated protein kinases ERK 1/2 and Phosphatidylinositol 3โ€“kinase by vanadyl sulfate, a protein tyrosine โ€ฆ
  1852. Cbl PYXXM motifs activate the P85 subunit of Phosphatidylinositol 3โ€“kinase, Crk, atypical protein kinase C, and glucose transport during thiazolidinedione action in โ€ฆ
  1853. An E2F-binding site mediates the activation of the proliferative isoform of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase by Phosphatidylinositol 3โ€“kinase
  1854. Association between the Met326Ile Polymorphism of the p85ฮฑ Regulatory Subunit of Phosphatidylinositol 3โ€“kinase and Prostate Cancer Risk: A Prospective Study
  1855. โ€ฆ coli K-1 interaction with human brain micro-vascular endothelial cells triggers phospholipase C-ฮณ1 activation downstream of Phosphatidylinositol 3โ€“kinase
  1856. Exposure to asphalt fumes activates activator protein-1 through the Phosphatidylinositol 3โ€“kinase/Akt signaling pathway in mouse epidermal cells
  1857. โ€ฆ Ethanol on the Rat Glutamate Excitatory Amino Acid Transporter Type 3 Expressed in Xenopus Oocytes: Role of Protein kinase C and Phosphatidylinositol 3โ€kinase
  1858. Functional role of Phosphatidylinositol 3โ€“kinase in direct tumor lysis by human natural killer cells
  1859. Involvement of type I protein kinase A in the differentiation of L6 myoblast in conjunction with Phosphatidylinositol 3โ€“kinase.
  1860. โ€ฆ cell cycle progression through the synthesis of c-Myc protein by internal ribosome entry siteโ€“mediated translation via Phosphatidylinositol 3โ€“kinase pathway in human โ€ฆ
  1861. Src tyrosine kinase-induced loss of luteinizing hormone responsiveness is via a Ras-dependent, Phosphatidylinositolโ€“3โ€“kinase independent pathway
  1862. A positive role of Phosphatidylinositol 3โ€“kinase in aging phenotype expression in cultured human diploid fibroblasts
  1863. Interleukin-2 receptors and interleukin-2-mediated signaling in myelin: activation of diacylglycerol kinase and Phosphatidylinositol 3โ€“kinase
  1864. Phosphatidylinositol 3โ€“kinase Inhibitor Failed to Reduce Cerebral Vasospasm in Dog Model of Experimental Subarachnoid Hemorrhage
  1865. Roles of tyrosine kinaseโ€“, 1-Phosphatidylinositol 3โ€“kinaseโ€“, and mitogen-activated protein kinaseโ€“signaling pathways in ethanol-induced contractions of rat aortic โ€ฆ
  1866. Activation and Phosphatidylinositol 3โ€“kinase-dependent phosphorylation of protein kinase C-epsilon by the B cell antigen receptor
  1867. Two modes of secretion in pancreatic acinar cells: involvement of Phosphatidylinositol 3โ€“kinase and regulation by capacitative Ca2+ entry
  1868. Lipidomic processes in homeostatic and LPS-modified cell renewal cycle. Role of Phosphatidylinositol 3โ€“kinase pathway in biomembrane synthesis and restitution of โ€ฆ
  1869. โ€ฆ pylori Lipopolysaccharide Interference with Gastric Mucin Synthesis by Peroxisome Proliferatorโ€Activated Receptor ฮณ Activation Involves Phosphatidylinositol 3โ€kinase โ€ฆ
  1870. Defective Activation of Atypical Protein kinase C ฮถ and ฮป by Insulin and Phosphatidylinositolโ€“3,4,5-(PO4)3 in Skeletal Muscle of Rats Following High-Fat Feeding and โ€ฆ
  1871. Rosiglitazone reverses insulin secretion altered by chronic exposure to free fatty acid via IRS-2-associated Phosphatidylinositol 3โ€“kinase pathway.
  1872. ฮฑ2 Adrenoceptorโ€mediated vasoconstriction in porcine palmar lateral vein: role of Phosphatidylinositol 3โ€kinase and EGF receptor transactivation
  1873. โ€ฆ factor-beta mediated contraction of human dermal fibroblast populated lattices is inhibited by Rho/GTPase inhibitor but does not require Phosphatidylinositolโ€“3โ€˜kinase.
  1874. ATP-sensitive K+ channel-mediated glucose uptake is independent of IRS-1/Phosphatidylinositol 3โ€“kinase signaling
  1875. Phosphatidylinositolโ€3 kinase p85 enhances expression from the myelin basic protein promoter in oligodendrocytes
  1876. Differential ligand recognition by the Src and Phosphatidylinositol 3โ€“kinase Src homology 3 domains: circular dichroism and ultraviolet resonance Raman studies
  1877. The role of Phosphatidylinositol 3โ€“kinase (PI3K) in CO2 stimulation of the Na+/HCO3-cotransporter (NBC)
  1878. Growth-inhibitory effect of Phosphatidylinositol 3โ€“kinase inhibitor on human pancreatic cancer cells and expression of Bcl-2 family.
  1879. Growth and Molecular Profile of Lung Cancer Cells Expressing Ectopic LKB1 Down-Regulation of the Phosphatidylinositol 3โ€ฒ-Phosphate kinase/PTEN Pathway
  1880. ARNO but not cytohesinโ€1 translocation is Phosphatidylinositol 3โ€kinaseโ€dependent in HLโ€60 cells
  1881. Stimulated tyrosine phosphorylation of Phosphatidylinositol 3โ€“kinase causes acidic pH-induced contraction in spontaneously hypertensive rat aorta
  1882. Signal transducer and activator of transcription-3 and Phosphatidylinositolโ€“3 kinase as coordinate regulators of melanoma cell response to glucocorticoid hormones
  1883. Phosphatidylinositolโ€“3 kinase-dependent activation of Akt does not correlate with either high mitogenicity or cell migration induced by FGF-1.
  1884. The Phosphatidylinositolโ€“3 kinase pathway is not essential for insulin-like growth factor I receptor-mediated clonogenic radioresistance
  1885. PDGF stimulates DNA synthesis in human vascular smooth muscle cells via a novel wortmannin-insensitive Phosphatidylinositol 3โ€“kinase
  1886. Promoter polymorphismsโˆ’ 359T/C andโˆ’ 303A/G of the catalytic subunit p110ฮฒ gene of human Phosphatidylinositol 3โ€“kinase are not associated with insulin secretion โ€ฆ
  1887. Co-operation of Phosphatidylinositol transfer protein with phosphoinositide 3โ€“kinase g in vitro
  1888. Activation of Phosphatidylinositol 3โ€“kinase in human breast carcinoma
  1889. Cell adhesion induces the plasminogen activator inhibitor-1 gene expression through Phosphatidylinositol 3โ€“kinase/Akt activation in anchorage dependent cells
  1890. Choline phosphate potentiates sphingosine-1-phosphate-induced Raf-1 kinase activation dependent of Rasโ€“Phosphatidylinositolโ€“3โ€“kinase pathway
  1891. In the article โ€œPhosphatidylinositol 3โ€“kinase Is Required for the Expression But Not for the Induction or the Maintenance of Long-Term Potentiation in the Hippocampal โ€ฆ
  1892. โ€ฆ cultured with a fusion protein of insulinโ€like growth factor II (IGFโ€II) and interleukin 3 (ILโ€3) is associated with increases in Bclโ€xL and Phosphatidylinositolโ€3 kinase โ€ฆ
  1893. Search for a molecular determinant in Phosphatidylinositolโ€“3โ€“kinase molecules, involved in the interaction with the beta-gamma-G protein dimer
  1894. Expression of an active p110 catalytic subunit of Phosphatidylinositol 3โ€kinase alters the proliferative capacity of interleukinโ€2 receptor signals
  1895. CD40 induces human multiple myeloma cell migration via Phosphatidylinositol 3โ€“kinase/AKT/NF-B signaling
  1896. Novel non-transcriptional mechanisms for estrogen receptor signaling in the cardiovascular system: Interaction of estrogen receptor ฮฑ with Phosphatidylinositol 3-OH โ€ฆ
  1897. Role of the Phosphatidylinositol 3 kinase-Akt
  1898. TNF-alpha induced chondrocyte apoptosis in NF-ฮบB suppression is augmented by inhibition of p38 mitogen-activated protein kinase or Phosphatidylinositol 3โ€“kinase
  1899. Defective Hyphal Induction of a Candida albicans Phosphatidylinositol 3-Phosphate 5-kinase Null Mutant on Solid Media Does Not Lead to Decreased Virulence
  1900. The biological effect of the Phosphatidylinositol 3โ€“kinase wortmannin following thermal neutron irradiation
  1901. Acetylcholine-induced production of reactive oxygen species in adult rabbit ventricular myocytes is dependent on Phosphatidylinositol 3-and Src-kinase activation and โ€ฆ
  1902. A Role for the Phosphatidylinositolโ€“3โ€“kinase Pathway in Preconditioning
  1903. Roles of Phosphatidylinositol 3โ€“kinase (PI3K) and Rac1
  1904. Roles of Phosphatidylinositol 3โ€“kinase (PI3K) and Rac 1
  1905. Gene expression profile analysis of the Phosphatidylinositol 3โ€“kinase pathway in the developing small intestine
  1906. Defining the physiological role of Phosphatidylinositol 3โ€“kinase protein kinase activity
  1907. Characterisation of aggresome formation by the class III Phosphatidylinositol 3โ€“kinase and its adaptor protein, p150.
  1908. Class IA Phosphatidylinositol 3โ€“kinase involvement in cytoskeletal regulation
  1909. Novel age-associated induction of components of the Phosphatidylinositolโ€“3 kinase (PI3K)/Akt signaling in the intestine
  1910. TEL/platelet-derived growth factor receptor ฮฒ activates Phosphatidylinositol 3 (PI3) kinase and requires PI3 kinase to regulate the cell cycle
  1911. Negative regulation of transforming growth factorbeta/SMAD by Phosphatidylinositol 3โ€“kinase pathway in neuroblastomas
  1912. Investigating the effect of altered nutrition on signalling via Drosophila class 1A Phosphatidylinositolโ€“3 kinase (PI3K), and functional analysis of PI3K mutated โ€ฆ
  1913. Connective tissue growth factor inhibits apoptosis of human hypertrophic scar fibroblasts through Phosphatidylinositol 3โ€“kinase/protein kinase B signal pathway
  1914. Regulation of androgen receptor activity and degradation by the Phosphatidylinositolโ€“3โ€“kinase/Akt pathway, PTEN tumor suppressor, and Mdm2
  1915. Epidermal growth factor-induced DNA synthesis: key roles for Phosphatidylinositol 3โ€“kinase and the adaptor protein Gab2
  1916. Requirement of BMP-2-induced Phosphatidylinositol 3โ€“kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene โ€ฆ
  1917. In vivo administration of glucosamine inhibited Phosphatidylinositol 3โ€“kinase activity without affecting tyrosine phosphorylation of the insulin receptor or insulin โ€ฆ
  1918. Functional Cooperation among Ras, STAT5, and Phosphatidylinositol 3โ€“kinase Is Required for Full Oncogenic Activities of BCR/ABL in K562 Cells
  1919. Apoptosis of differentiated HL-60 cells induced by inhibitor of Phosphatidylinositol 3โ€“kinase
  1920. 1141. Insulin-Like Growth Factor-1 Enhances Plasmid Transgene Expression through a Phosphatidylinositol 3โ€“kinase-Dependent Pathway
  1921. Phosphatidylinositol (3, 4, 5) P3 is essential but not sufficient for protein kinase B (PKB) activation; Phosphatidylinositol (3, 4) P2 is required for PKB โ€ฆ
  1922. DEFECTS IN INTERMEDIATE INSULIN SIGNALING IN SKELETAL MUSCLE: Phosphatidylinositol (PI) 3โ€“kinase AND GLUCOSE TRANSPORT
  1923. โ€ฆ CANCER: ANTIMONY VERSUS TECHNETIUM-99 FILTERED SULFUR COLLOID52. THE INVOLVEMENT OF Phosphatidylinositol 3โ€“kinase (PI3-K)/AKT โ€ฆ
  1924. Insulin activates CCAAT/enhancer binding proteins and proinflammatory gene expression through the Phosphatidylinositol 3โ€“kinase pathway in vascular smooth โ€ฆ
  1925. Phosphatidylinositol kinase enzymes regulate the retrograde axonal transport of NTโ€3 and NTโ€4 in sympathetic and sensory neurons
  1926. The Role of Phosphatidylinositol 3โ€˜-OH kinase Signaling in Mammary Tumorigenesis
  1927. Epithelialโ€“mesenchymal transition in development and cancer: role of Phosphatidylinositol 3โ€ฒ kinase/AKT pathways
  1928. The pivotal role of Phosphatidylinositol 3โ€“kinaseโ€“Akt signal transduction in virus survival
  1929. Phosphatidylinositol 3โ€“kinase mutations identified in human cancer are oncogenic
  1930. Targeting the Phosphatidylinositolโ€“3 kinase/Akt pathway for the treatment of cancer.
  1931. Inhibition of Rho-kinase leads to rapid activation of Phosphatidylinositol 3โ€“kinase/protein kinase Akt and cardiovascular protection
  1932. The prognostic significance of Phosphatidylinositol 3โ€“kinase pathway activation in human gliomas
  1933. Exercise activates the Phosphatidylinositol 3โ€“kinase pathway
  1934. Early involvement of the Phosphatidylinositol 3โ€“kinase/Akt pathway in lung cancer progression
  1935. Postconditioning: a form of โ€œmodified reperfusionโ€ protects the myocardium by activating the Phosphatidylinositol 3โ€“kinase-Akt pathway
  1936. Cell type-specific expression of the IฮบB kinases determines the significance of Phosphatidylinositol 3โ€“kinase/Akt signaling to NF-ฮบB activation
  1937. Type I transforming growth factor ฮฒ receptor binds to and activates Phosphatidylinositol 3โ€“kinase
  1938. Phosphatidylinositol 3โ€“kinaseโ€“Akt pathway plays a critical role in early cardiomyogenesis by regulating canonical Wnt signaling
  1939. Regulation of Cu/Zn-superoxide dismutase expression via the Phosphatidylinositol 3 kinase/Akt pathway and nuclear factor-ฮบB
  1940. The Phosphatidylinositolโ€3 kinase pathway regulates bladder cancer cell invasion
  1941. Novel role for Na, K-ATPase in Phosphatidylinositol 3โ€“kinase signaling and suppression of cell motility
  1942. Inhibition of Phosphatidylinositol 3โ€“kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias.
  1943. โ€ฆ growth factor transcriptional activation is mediated by hypoxia-inducible factor 1ฮฑ, HDM2, and p70S6K1 in response to Phosphatidylinositol 3โ€“kinase/AKT โ€ฆ
  1944. โ€ฆ metabolites stimulate endothelial cell growth and angiogenesis via mitogen-activated protein kinase and Phosphatidylinositol 3โ€“kinase/Akt signaling pathways
  1945. Focal adhesion kinase is upstream of Phosphatidylinositol 3โ€“kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices โ€ฆ
  1946. Pancreatic stellate cell migration: role of the Phosphatidylinositol 3โ€“kinase (PI3โ€“kinase) pathway
  1947. Inhibition of the Phosphatidylinositol 3โ€“kinase/Akt pathway by inositol pentakisphosphate results in antiangiogenic and antitumor effects
  1948. Tobacco Carcinogen-Induced Cellular Transformation Increases Activation of the Phosphatidylinositol 3โ€ฒ-kinase/Akt Pathway in Vitro and in Vivo
  1949. Phosphatidylinositolโ€“3โ€“kinase signaling is required for erythropoietin-mediated acute protection against myocardial ischemia/reperfusion injury
  1950. Activation of the Phosphatidylinositol 3โ€“kinase/Akt pathway contributes to survival of primary epithelial cells infected with the periodontal pathogen Porphyromonas โ€ฆ
  1951. Cutting edge: T cell development requires the combined activities of the p110ฮณ and p110ฮด catalytic isoforms of Phosphatidylinositol 3โ€“kinase
  1952. Auxin-induced reactive oxygen species production requires the activation of Phosphatidylinositol 3โ€“kinase
  1953. Involvement of the Phosphatidylinositol 3โ€“kinase/rac1 and cdc42 pathways in radial migration of cortical neurons
  1954. Nongenomic androgen activation of Phosphatidylinositol 3โ€kinase/Akt signaling pathway in MC3T3โ€E1 osteoblasts
  1955. Flavivirus activates Phosphatidylinositol 3โ€“kinase signaling to block caspase-dependent apoptotic cell death at the early stage of virus infection
  1956. Activation of the pro-survival Phosphatidylinositol 3โ€“kinase/AKT pathway by transforming growth factor-ฮฒ1 in mesenchymal cells is mediated by p38 MAPK โ€ฆ
  1957. Phosphatidylinositol 3โ€“kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization
  1958. Interleukin-18 is a pro-hypertrophic cytokine that acts through a Phosphatidylinositol 3โ€“kinase-phosphoinositide-dependent kinase-1-Akt-GATA4 signaling โ€ฆ
  1959. The p85ฮฑ subunit of Phosphatidylinositol 3โ€ฒ-kinase binds to and stimulates the GTPase activity of Rab proteins
  1960. Knockdown of MTP18, a novel Phosphatidylinositol 3โ€“kinase-dependent protein, affects mitochondrial morphology and induces apoptosis
  1961. Cross-Talk between Phosphatidylinositol 3โ€“kinase/AKT and c-Jun NH2-Terminal kinase Mediates Survival of Isolated Human Islets
  1962. Endoplasmic reticulum stressโ€“induced apoptosis is partly mediated by reduced insulin signaling through Phosphatidylinositol 3โ€“kinase/Akt and increased glycogen โ€ฆ
  1963. Bisphenol a accelerates terminal differentiation of 3T3-L1 cells into adipocytes through the Phosphatidylinositol 3โ€“kinase pathway
  1964. Lithium activates the Wnt and Phosphatidylinositol 3โ€“kinase Akt signaling pathways to promote cell survival in the absence of soluble survival factors
  1965. Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by Phosphatidylinositol 3โ€“kinase/protein kinase B inhibitors
  1966. Adrenomedullin infusion attenuates myocardial ischemia/reperfusion injury through the Phosphatidylinositol 3โ€“kinase/Akt-dependent pathway
  1967. Activation of Phosphatidylinositol 3โ€“kinase by cellular prion protein and its role in cell survival
  1968. BDNF regulates the translation of a select group of mRNAs by a mammalian target of rapamycin-Phosphatidylinositol 3โ€“kinase-dependent pathway during neuronal โ€ฆ
  1969. Inhibition of Phosphatidylinositol 3โ€ฒ-kinase/AKT signaling promotes apoptosis of primary effusion lymphoma cells
  1970. The Phosphatidylinositol 3โ€“kinase/Akt pathway enhances Smad3-stimulated mesangial cell collagen I expression in response to transforming growth factor-ฮฒ1
  1971. Phosphatidylinositol 3โ€ฒ-kinase activation leads to multidrug resistance protein-1 expression and subsequent chemoresistance in advanced prostate cancer cells
  1972. Latent membrane protein 2A inhibits transforming growth factor-ฮฒ1-induced apoptosis through the Phosphatidylinositol 3โ€“kinase/Akt pathway
  1973. Microglia release activators of neuronal proliferation mediated by activation of mitogenโ€activated protein kinase, Phosphatidylinositolโ€3โ€kinase/Akt and deltaโ€“Notch โ€ฆ
  1974. Acanthamoeba castellanii Induces Host Cell Death via a Phosphatidylinositol 3โ€“kinase-Dependent Mechanism
  1975. Regulation of muscle protein degradation: coordinated control of apoptotic and ubiquitin-proteasome systems by Phosphatidylinositol 3 kinase
  1976. Both mitogen-activated protein kinase and Phosphatidylinositol 3โ€“kinase signalling are required in epidermal growth factor-induced human trophoblast migration
  1977. โ€ฆ protein regulation of early osteoblast genes in human marrow stromal cells is mediated by extracellular signal-regulated kinase and Phosphatidylinositol 3โ€“kinase โ€ฆ
  1978. Ceramide-1-phosphate promotes cell survival through activation of the Phosphatidylinositol 3โ€“kinase/protein kinase B pathway
  1979. โ€ฆ inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting Phosphatidylinositol 3โ€ฒ-kinase โ€ฆ
  1980. Gi-protein-dependent inhibition of IL-12 production is mediated by activation of the Phosphatidylinositol 3โ€“kinase-protein 3 kinase B/Akt pathway and JNK
  1981. โ€ฆ through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the Phosphatidylinositol 3โ€“kinase/Akt-dependent pathway
  1982. Emodin inhibits tumor cell migration through suppression of the Phosphatidylinositol 3โ€“kinase-Cdc42/Rac1 pathway
  1983. Inhibition of Phosphatidylinositol 3โ€“kinase sensitizes ovarian cancer cells to carboplatin and allows adjunct chemotherapy treatment
  1984. โ€ฆ Induces Rapid Activation of Akt/Protein kinase B-Mammalian Target of Rapamycin-p70S6K Cascade through Phosphatidylinositol 3โ€“kinase in Human Fibroblasts
  1985. REDD1 integrates hypoxia-mediated survival signaling downstream of Phosphatidylinositol 3โ€“kinase
  1986. Mechanisms of erythropoietinโ€mediated cardioprotection during ischemiaโ€reperfusion injury: role of protein kinase C and Phosphatidylinositol 3โ€kinase signaling
  1987. Sequential Activation of Phosphatidylinositol 3โ€“kinase, ฮฒPix, Rac1, and Nox1 in Growth Factor-Induced Production of H2O2
  1988. Production of matrix metalloproteinaseโ€9 by activated human monocytes involves a Phosphatidylinositolโ€3 kinase/Akt/IKKฮฑ/NFโ€ฮบB pathway
  1989. Isoflurane protects against myocardial infarction during early reperfusion by activation of Phosphatidylinositolโ€“3โ€“kinase signal transduction: evidence for anesthetic โ€ฆ
  1990. โ€ฆ progenitors and differentiated osteoblasts by ฮฒ-catenin-dependent and-independent signaling cascades involving Src/ERK and Phosphatidylinositol 3โ€“kinase โ€ฆ
  1991. Differential membrane localization of ERas and Rheb, two Ras-related proteins involved in the Phosphatidylinositol 3โ€“kinase/mTOR pathway
  1992. Human placental growth hormone increases expression of the p85 regulatory unit of Phosphatidylinositol 3โ€“kinase and triggers severe insulin resistance in skeletal โ€ฆ
  1993. Induction of androgen receptor expression by Phosphatidylinositol 3โ€“kinase/Akt downstream substrate, FOXO3a, and their roles in apoptosis of LNCaP โ€ฆ
  1994. Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and Phosphatidylinositol 3โ€“kinase/Akt signaling
  1995. WAVE3-mediated cell migration and lamellipodia formation are regulated downstream of Phosphatidylinositol 3โ€“kinase
  1996. Role of Phosphatidylinositol 3โ€“kinase in the development of hepatocyte preconditioning
  1997. Overexpression of NBS1 contributes to transformation through the activation of Phosphatidylinositol 3โ€“kinase/Akt
  1998. TGF-ฮฒ1 represses activation and resultant death of microglia via inhibition of Phosphatidylinositol 3โ€“kinase activity
  1999. Inhibition of Phosphatidylinositol 3โ€“kinase amplifies TEGDMA-induced apoptosis in primary human pulp cells
  2000. Mutant epidermal growth factor receptor displays increased signaling through the Phosphatidylinositolโ€“3 kinase/AKT pathway and promotes radioresistance in cells of โ€ฆ
  2001. Atypical protein kinase C (PKCฮถ/ฮป) is a convergent downstream target of the insulin-stimulated Phosphatidylinositol 3โ€“kinase and TC10 signaling pathways
  2002. Lipopolysaccharide-induced c-Jun NH2-terminal kinase activation in human neutrophils: role of Phosphatidylinositol 3โ€“kinase and Syk-mediated pathways
  2003. Modulation of Phosphatidylinositolโ€3โ€kinase/protein kinase Bโ€and mitogenโ€activated protein kinaseโ€pathways by tea polyphenols in human prostate cancer cells
  2004. Inhibition of Phosphatidylinositolโ€“3โ€“kinase causes increased sensitivity to radiation through a PKB-dependent mechanism
  2005. Statins prevent oxidized LDL-induced injury of glomerular podocytes by activating the Phosphatidylinositol 3โ€“kinase/AKT-signaling pathway
  2006. Akt2, a novel functional link between p38 mitogen-activated protein kinase and Phosphatidylinositol 3โ€“kinase pathways in myogenesis
  2007. Leptin increases cardiomyocyte hyperplasia via extracellular signal-regulated kinase-and Phosphatidylinositol 3โ€“kinase-dependent signaling pathways
  2008. Regulation of heme oxygenase-1 expression through the Phosphatidylinositol 3โ€“kinase/Akt pathway and the Nrf2 transcription factor in response to the โ€ฆ
  2009. Mammalian target of rapamycin positively regulates collagen type I production via a Phosphatidylinositol 3โ€“kinase-independent pathway
  2010. Alteration of Phosphatidylinositol 3โ€“kinase cascade in the multilobulated nuclear formation of adult T cell leukemia/lymphoma (ATLL)
  2011. Aging is associated with decreased pancreatic acinar cell regeneration and Phosphatidylinositol 3โ€“kinase/Akt activation
  2012. Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the Phosphatidylinositol 3โ€“kinase/Akt/mammalian target of rapamycin (PI3K โ€ฆ
  2013. PIKE (Phosphatidylinositol 3โ€“kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion
  2014. Se-methylselenocysteine inhibits Phosphatidylinositol 3โ€“kinase activity of mouse mammary epithelial tumor cells in vitro
  2015. CXCL16 signals via Gi, Phosphatidylinositol 3โ€“kinase, Akt, IฮบB kinase, and nuclear factor-ฮบB and induces cell-cell adhesion and aortic smooth muscle cell โ€ฆ
  2016. Dexamethasone induces apoptosis in proliferative chondrocytes through activation of caspases and suppression of the Akt-Phosphatidylinositol 3โ€ฒ-kinase signaling โ€ฆ
  2017. WNK1 activates SGK1 by a Phosphatidylinositol 3โ€“kinase-dependent and non-catalytic mechanism
  2018. Phosphatidylinositol 3โ€“kinase-Mediated Effects of Glucose on Vacuolar H+-ATPase Assembly, Translocation, and Acidification of Intracellular Compartments in Renal โ€ฆ
  2019. The Phosphatidylinositolโ€“3โ€“kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human nonโ€“small cell โ€ฆ
  2020. โ€ฆ protein Gab1 is an essential component of an indirect mechanism for fibroblast growth factor stimulation of the Phosphatidylinositol 3โ€“kinase/Akt antiapoptotic pathway
  2021. Transforming growth factor-ฮฒ activation of Phosphatidylinositol 3โ€“kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated โ€ฆ
  2022. Isoflurane-induced myocardial preconditioning is dependent on Phosphatidylinositolโ€“3โ€“kinase/Akt signalling
  2023. PTEN, but not SHIP2, suppresses insulin signaling through the Phosphatidylinositol 3โ€“kinase/Akt pathway in 3T3-L1 adipocytes
  2024. Retroinfusion of embryonic endothelial progenitor cells attenuates ischemia-reperfusion injury in pigs: role of Phosphatidylinositol 3โ€“kinase/AKT kinase
  2025. โ€ฆ stress induces insulin resistance by activating the nuclear factor-ฮบB pathway and disrupting normal subcellular distribution of Phosphatidylinositol 3โ€“kinase
  2026. Phosphatidylinositol 3โ€“kinase C2ฮฑ is essential for ATP-dependent priming of neurosecretory granule exocytosis
  2027. โ€ฆ -macrophage colony-stimulating factor signaling and microglial proliferation by anti-CD45RO: role of Hck tyrosine kinase and Phosphatidylinositol 3โ€“kinase/Akt
  2028. Phosphatidylinositol 3โ€“kinase and mTOR signaling pathways regulate RNA polymerase I transcription in response to IGF-1 and nutrients
  2029. Presenilins mediate Phosphatidylinositol 3โ€“kinase/AKT and ERK activation via select signaling receptors: selectivity of PS2 in platelet-derived growth factor โ€ฆ
  2030. Cross-talk between CD14 and complement receptor 3 promotes phagocytosis of mycobacteria: regulation by Phosphatidylinositol 3โ€“kinase and cytohesin-1
  2031. Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a Phosphatidylinositol 3โ€“kinase/Akt and p38 kinase-dependent STAT3 โ€ฆ
  2032. Phosphatidylinositol 3โ€kinase and Akt effectors mediate insulinโ€like growth factorโ€I neuroprotection in dorsal root ganglia neurons
  2033. Transformation potential of Ras isoforms correlates with activation of Phosphatidylinositol 3โ€“kinase but not ERK
  2034. Hypoxia-induced activation of p38 mitogen-activated protein kinase and Phosphatidylinositol 3โ€ฒ-kinase signaling pathways contributes to expression of interleukin 8 โ€ฆ
  2035. Participation of prolactin receptors and Phosphatidylinositol 3โ€“kinase and MAP kinase pathways in the increase in pancreatic islet mass and sensitivity to โ€ฆ
  2036. โ€ฆ ligand (TRAIL) induces rheumatoid arthritis synovial fibroblast proliferation through mitogen-activated protein kinases and Phosphatidylinositol 3โ€“kinase/Akt
  2037. A3 adenosine receptor activation inhibits cell proliferation via Phosphatidylinositol 3โ€“kinase/Akt-dependent inhibition of the extracellular signal-regulated โ€ฆ
  2038. โ€ฆ -I regulates proliferation and osteoblastic differentiation of calcifying vascular cells via extracellular signal-regulated protein kinase and Phosphatidylinositol 3โ€“kinase โ€ฆ
  2039. โ€ฆ affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through Phosphatidylinositol 3โ€“kinase โ€ฆ
  2040. Increased phosphorylation of AKAP by inhibition of Phosphatidylinositol 3โ€“kinase enhances human sperm motility through tail recruitment of protein kinase A
  2041. Vacuolar H+-ATPase binding to microfilaments: regulation in response to Phosphatidylinositol 3โ€“kinase activity and detailed characterization of the actin โ€ฆ
  2042. Inhibition of Phosphatidylinositol 3โ€“kinase modifies boar sperm motion parameters
  2043. Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the Phosphatidylinositol 3โ€“kinase-Akt pathway
  2044. Phosphatidylinositol 3โ€“kinase inhibition down-regulates survivin and facilitates TRAIL-mediated apoptosis in neuroblastomas
  2045. Phosphatidylinositol 3โ€“kinase/Akt regulates angiotensin IIโ€“induced inhibition of apoptosis in microvascular endothelial cells by governing survivin expression and โ€ฆ
  2046. Insulin-mediated down-regulation of apolipoprotein A5 gene expression through the Phosphatidylinositol 3โ€“kinase pathway: role of upstream stimulatory factor
  2047. Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: the Phosphatidylinositol 3โ€“kinase/Akt and Raf/ERK pathways transmit โ€ฆ
  2048. โ€ฆ induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the Phosphatidylinositol 3โ€“kinase/PTEN/AKT/mammalian โ€ฆ
  2049. Phosphatidylinositol 3โ€“kinase is required for rhinovirus-induced airway epithelial cell interleukin-8 expression
  2050. Zn2+ inhibits mitochondrial movement in neurons by Phosphatidylinositol 3โ€“kinase activation
  2051. โ€ฆ activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/Phosphatidylinositol 3โ€“kinase โ€ฆ
  2052. Activation of Phosphatidylinositol 3โ€“kinase and extracellular signal-regulated kinase is required for glial cell line-derived neurotrophic factor-induced migration and โ€ฆ
  2053. Platelet-derived growth factor stimulates membrane lipid synthesis through activation of Phosphatidylinositol 3โ€“kinase and sterol regulatory element-binding โ€ฆ
  2054. Phosphatidylinositol 3โ€“kinase is involved in ฮฑ2 (I) collagen gene expression in normal and scleroderma fibroblasts
  2055. IGF-I inhibits apoptosis through the activation of the Phosphatidylinositol 3โ€“kinase/Akt pathway in pituitary cells
  2056. Phosphatidylinositol 3โ€“kinase Offsets cAMP-Mediated Positive Inotropic Effect via Inhibiting Ca2+ Influx in Cardiomyocytes
  2057. Formation of E-cadherin-mediated cell-cell adhesion activates AKT and mitogen activated protein kinase via Phosphatidylinositol 3 kinase and ligand-independent โ€ฆ
  2058. Lipoteichoic acid induces nuclear factorโ€ฮบB activation and nitric oxide synthase expression via Phosphatidylinositol 3โ€kinase, Akt, and p38 MAPK in RAW 264.7 โ€ฆ
  2059. Glucocorticoid receptor counteracts tumorigenic activity of Akt in skin through interference with the Phosphatidylinositol 3โ€“kinase signaling pathway
  2060. Phosphatidylinositolโ€“3 kinase/Akt and GSK-3 mediated cytoprotective effect of epigallocatechin gallate on oxidative stress-injured neuronal-differentiated N18D3 cells
  2061. Identification of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) as a novel downstream target of Phosphatidylinositol 3โ€“kinase/AKT/GSK-3ฮฒ โ€ฆ
  2062. โ€ฆ -dependent insulinotropic polypeptide (GIP) stimulation of pancreatic ฮฒ-cell survival is dependent upon Phosphatidylinositol 3โ€“kinase (PI3K)/protein kinase B โ€ฆ
  2063. Role of the Phosphatidylinositol 3โ€ฒ-kinaseโ€“Akt signal pathway in the proliferation of human pancreatic ductal carcinoma cell lines
  2064. Signal regulatory protein ฮฑ ligation induces macrophage nitric oxide production through JAK/STAT-and Phosphatidylinositol 3โ€“kinase/Rac1/NAPDH oxidase/H2O2 โ€ฆ
  2065. Stable activation of Phosphatidylinositol 3โ€“kinase in the T cell immunological synapse stimulates Akt signaling to FoxO1 nuclear exclusion and cell growth control
  2066. Activation of the Phosphatidylinositol 3โ€“kinase/Akt pathway prevents radiation-induced apoptosis in breast cancer cells
  2067. Hyaluronic acid induces osteopontin via the Phosphatidylinositol 3โ€“kinase/Akt pathway to enhance the motility of human glioma cells
  2068. โ€ฆ regulated by coexpression of human epidermal growth factor receptor 2 and epidermal growth factor receptor via Phosphatidylinositol 3โ€“kinase/AKT signaling pathway โ€ฆ
  2069. CD28 regulates the translation of Bcl-xL via the Phosphatidylinositol 3โ€“kinase/mammalian target of rapamycin pathway
  2070. Impaired activation of Phosphatidylinositol 3โ€“kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity
  2071. Regulation of cholinergic gene expression by nerve growth factor depends on the Phosphatidylinositolโ€3โ€ฒโ€kinase pathway
  2072. Inhibition of Phosphatidylinositol 3โ€ฒ-kinase induces preferentially killing of PTEN-null T leukemias through AKT pathway
  2073. Nickel Compounds Act through Phosphatidylinositolโ€“3โ€“kinase/Akt-Dependent, p70S6k-Independent Pathway to Induce Hypoxia Inducible Factor Transactivation and โ€ฆ
  2074. Enteric neuroblasts require the Phosphatidylinositol 3โ€“kinase/Akt/Forkhead pathway for GDNF-stimulated survival
  2075. Differential activation of the Phosphatidylinositol 3โ€ฒ-kinase/Akt survival pathway by ionizing radiation in tumor and primary endothelial cells
  2076. Activation of Rac1 by Phosphatidylinositol 3โ€kinase in vivo: role in activation of mitogenโ€activated protein kinase (MAPK) pathways and retinoic acidโ€induced โ€ฆ
  2077. Induction of KLF2 by fluid shear stress requires a novel promoter element activated by a Phosphatidylinositol 3โ€“kinase-dependent chromatin-remodeling โ€ฆ
  2078. Insulin generates free radicals by an NAD (P) H, Phosphatidylinositol 3โ€ฒ-kinase-dependent mechanism in human skin fibroblasts ex vivo
  2079. Insulin-like growth factor-1 regulates endogenous RUNX2 activity in endothelial cells through a Phosphatidylinositol 3โ€“kinase/ERK-dependent and Akt โ€ฆ
  2080. Phosphatidylinositol 3โ€“kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42
  2081. โ€ฆ /human herpesvirus 8 envelope glycoprotein gB induces the integrin-dependent focal adhesion kinase-Src-Phosphatidylinositol 3โ€“kinase-rho GTPase signal pathways โ€ฆ
  2082. Nerve growth factor promotes the survival of sympathetic neurons through the cooperative function of the protein kinase C and Phosphatidylinositol 3โ€“kinase โ€ฆ
  2083. Roles of the Ras-MEK-mitogen-activated protein kinase and Phosphatidylinositol 3โ€“kinase-Akt-mTOR pathways in Jaagsiekte sheep retrovirus-induced transformation โ€ฆ
  2084. Inhibition of p38 mitogen-activated protein kinase and Phosphatidylinositol 3โ€“kinase decreases UVB-induced activator protein-1 and cyclooxygenase-2 in a SKH-1 โ€ฆ
  2085. โ€ฆ induces proliferation, migration, and TGF-ฮฒ1 expression in mouse glomerular endothelial cells via mitogen-activated protein kinase and Phosphatidylinositol 3โ€“kinase
  2086. p38 and EGF receptor kinase-mediated activation of the Phosphatidylinositol 3โ€“kinase/Akt pathway is required for Zn2+-induced cyclooxygenase-2 expression
  2087. Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the Phosphatidylinositol 3โ€“kinase/AKT/Ras homolog enriched in brain (Rheb) โ€ฆ
  2088. โ€ฆ line-derived neurotrophic factor increases intracellular calcium concentration: role of calcium/calmodulin in the activation of the Phosphatidylinositol 3โ€“kinase โ€ฆ
  2089. Reciprocal control of Forkhead box O 3a and c-Myc via the Phosphatidylinositol 3โ€“kinase pathway coordinately regulates p27Kip1 levels
  2090. Facilitation of conditioned fear extinction by d-cycloserine is mediated by mitogen-activated protein kinase and Phosphatidylinositol 3โ€“kinase cascades and requires โ€ฆ
  2091. โ€ฆ box transcription factor FOXO3a regulates estrogen receptor alpha expression and is repressed by the Her-2/neu/Phosphatidylinositol 3โ€“kinase/Akt signaling pathway
  2092. Medroxyprogesterone acetate induces cell proliferation through up-regulation of cyclin D1 expression via Phosphatidylinositol 3โ€“kinase/Akt/nuclear factor-ฮบB cascade โ€ฆ
  2093. โ€ฆ is enhanced by N-methyl-D-aspartate receptor activation: essential role of a TNF receptor 2-mediated Phosphatidylinositol 3โ€“kinase-dependent NF-ฮบB โ€ฆ
  2094. LY294002 inhibits LPS-induced NO production through a inhibition of NF-ฮบB activation: independent mechanism of Phosphatidylinositol 3โ€“kinase
  2095. Resistin promotes smooth muscle cell proliferation through activation of extracellular signalโ€“regulated kinase 1/2 and Phosphatidylinositol 3โ€“kinase pathways
  2096. A late, prolonged activation of the Phosphatidylinositol 3โ€“kinase pathway is required for T cell proliferation
  2097. Morphine enhances isoflurane-induced postconditioning against myocardial infarction: the role of Phosphatidylinositolโ€“3โ€“kinase and opioid receptors in rabbits
  2098. Calcium-induced Human Keratinocyte Differentiation Requires src- and fyn-mediated Phosphatidylinositol 3โ€“kinaseโ€“dependent Activation of Phospholipase C-ฮณ1
  2099. FGF-2 induced by interleukin-1ฮฒ through the action of Phosphatidylinositol 3โ€“kinase mediates endothelial mesenchymal transformation in corneal endothelial โ€ฆ
  2100. โ€ฆ of peroxisome proliferator-activated receptor-ฮณ by insulin and C-peptide in kidney proximal tubular cells: dependent on Phosphatidylinositol 3โ€“kinase activity
  2101. IL-18 induces monocyte chemotactic protein-1 production in macrophages through the Phosphatidylinositol 3โ€“kinase/Akt and MEK/ERK1/2 pathways
  2102. Erythropoietin just before reperfusion reduces both lethal arrhythmias and infarct size via the Phosphatidylinositolโ€“3 kinase-dependent pathway in canine hearts
  2103. FSH activates Phosphatidylinositol 3โ€“kinase/protein kinase B signaling pathway in 20-day-old Sertoli cells independently of IGF-I
  2104. Dexamethasone suppresses antigen-induced activation of Phosphatidylinositol 3โ€“kinase and downstream responses in mast cells
  2105. Inhibition of the Phosphatidylinositol 3โ€“kinase/Akt/mammalian target of rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung โ€ฆ
  2106. Apoptosis and inhibition of the Phosphatidylinositol 3โ€“kinase/Akt signaling pathway in the anti-proliferative actions of dehydroepiandrosterone
  2107. Identification of transcription factor binding sites upstream of human genes regulated by the Phosphatidylinositol 3โ€“kinase and MEK/ERK signaling pathways
  2108. Up-regulation of endothelial nitric oxide synthase via Phosphatidylinositol 3โ€“kinase pathway contributes to ischemic tolerance in the CA1 subfield of gerbil โ€ฆ
  2109. TRAIL-induced apoptosis in human vascular endothelium is regulated by Phosphatidylinositol 3โ€“kinase/Akt through the short form of cellular FLIP and Bcl-2
  2110. Topical treatment with inhibitors of the Phosphatidylinositol 3โ€ฒ-kinase/Akt and Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase โ€ฆ
  2111. Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and Phosphatidylinositol 3โ€“kinase signaling
  2112. A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by Phosphatidylinositolโ€“3 kinase/Akt in HER2 overexpressing cells
  2113. IL-2 increases human telomerase reverse transcriptase activity transcriptionally and posttranslationally through Phosphatidylinositol 3โ€ฒ-kinase/Akt, heat shock protein โ€ฆ
  2114. FasL (CD95L/APO-1L) resistance of neurons mediated by Phosphatidylinositol 3โ€“kinase-Akt/protein kinase B-dependent expression of lifeguard/neuronal membrane โ€ฆ
  2115. A role for Phosphatidylinositol 3โ€“kinase in TCR-stimulated ERK activation leading to paxillin phosphorylation and CTL degranulation
  2116. Systematic evaluation of anti-apoptotic growth factor signaling in vascular smooth muscle cells: only Phosphatidylinositol 3โ€ฒ-kinase is important
  2117. Neuroprotective effects of the synthetic cannabinoid HU-210 in primary cortical neurons are mediated by Phosphatidylinositol 3โ€“kinase/AKT signaling
  2118. Restoration of SHIP activity in a human leukemia cell line downregulates constitutively activated Phosphatidylinositol 3โ€“kinase/Akt/GSK-3ฮฒ signaling and leads to an โ€ฆ
  2119. Trophic signals acting via Phosphatidylinositolโ€“3 kinase are required for normal pre-implantation mouse embryo development
  2120. Human mesothelioma cells exhibit tumor cellโ€“specific differences in Phosphatidylinositol 3โ€“kinase/AKT activity that predict the efficacy of Onconase
  2121. โ€ฆ lipoprotein inhibits thrombin-induced endothelial tissue factor expression through inhibition of RhoA and stimulation of Phosphatidylinositol 3โ€“kinase but not Akt โ€ฆ
  2122. Inhibition of Phosphatidylinositol 3โ€“kinase-and ERK MAPK-regulated protein synthesis reveals the pro-apoptotic properties of CD40 ligation in carcinoma cells
  2123. HIVโ€1 gp120โ€induced TNFโ€ฮฑ production by primary human macrophages is mediated by Phosphatidylinositolโ€3 (PIโ€3) kinase and mitogenโ€activated protein (MAP) โ€ฆ
  2124. โ€ฆ proliferator-activated receptor-ฮณ by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a Phosphatidylinositol 3โ€ฒ-kinase โ€ฆ
  2125. A linear signal transduction pathway involving Phosphatidylinositol 3โ€“kinase, protein kinase Cฯต, and MAPK in mesangial cells regulates interferon-ฮณ-induced โ€ฆ
  2126. Inhibition of Phosphatidylinositol 3โ€“kinase/Akt and histone deacetylase activity induces apoptosis in nonโ€“small cell lung cancer in vitro and in vivo
  2127. Interaction and functional analyses of human VPS34/p150 Phosphatidylinositol 3โ€kinase complex with Rab7
  2128. The pro-inflammatory mediator leukotriene D4 induces Phosphatidylinositol 3โ€“kinase and Rac-dependent migration of intestinal epithelial cells
  2129. โ€ฆ -Induced Oocyte Maturation in Atlantic Croaker (Micropogonias undulatus) Is Dependent on Activation of the Phosphatidylinositol 3โ€“kinase/Akt Signal Transduction โ€ฆ
  2130. Inhibition of the Phosphatidylinositol 3โ€ฒ-kinase signaling pathway leads to decreased insulin-stimulated adiponectin secretion from 3T3-L1 adipocytes
  2131. Treating breast cancer through novel inhibitors of the Phosphatidylinositol 3โ€˜-kinase pathway
  2132. Phosphatidylinositol 3โ€kinase and Akt participate in the FSHโ€induced meiotic maturation of mouse oocytes
  2133. Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits Phosphatidylinositol 3โ€“kinase through binding to PIKE-L
  2134. Activation of Phosphatidylinositol 3โ€“kinase, Akt, and mammalian target of rapamycin is necessary for hypoxia-induced pulmonary artery adventitial fibroblast โ€ฆ
  2135. The magnitude of Akt/Phosphatidylinositol 3โ€ฒ-kinase proliferating signaling is related to CD45 expression in human myeloma cells
  2136. Response of Nonโ€“Small Cell Lung Cancer Cells to the Inhibitors of Phosphatidylinositol 3โ€“kinase/Akt- and MAPK kinase 4/c-Jun NH2-Terminal kinase Pathways โ€ฆ
  2137. RhoA activation mediates Phosphatidylinositol 3โ€“kinaseโ€“dependent proliferation of human vascular endothelial cells: an alloimmune mechanism of chronic allograft โ€ฆ
  2138. Insulin-like growth factor 1 inhibits extracellular signal-regulated kinase to promote neuronal survival via the Phosphatidylinositol 3โ€“kinase/protein kinase A/c-Raf โ€ฆ
  2139. โ€ฆ substrate metabolism of mouse cumulus-oocyte complexes: response to follicle-stimulating hormone is mediated by the Phosphatidylinositol 3โ€“kinase pathway and is โ€ฆ
  2140. A Rac1/Phosphatidylinositol 3โ€“kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide โ€ฆ
  2141. Protein phosphatase-2Cฮฑ as a positive regulator of insulin sensitivity through direct activation of Phosphatidylinositol 3โ€“kinase in 3T3-L1 adipocytes
  2142. Suppression of Phosphatidylinositol 3โ€“kinase/Akt signaling pathway is a determinant of the sensitivity to a novel histone deacetylase inhibitor, FK228, in lung โ€ฆ
  2143. Phosphatidylinositol 3โ€“kinase signaling is involved in neurogenesis during Xenopus embryonic development
  2144. Phosphatidylinositolโ€3 kinase is distinctively required for ยตโ€, but not ฮบโ€opioid receptorโ€induced activation of cโ€Jun Nโ€terminal kinase
  2145. AMPA protects cultured neurons against glutamate excitotoxicity through a Phosphatidylinositol 3โ€kinaseโ€dependent activation in extracellular signalโ€regulated โ€ฆ
  2146. N-WASP and WAVE2 acting downstream of Phosphatidylinositol 3โ€“kinase are required for myogenic cell migration induced by hepatocyte growth factor
  2147. Differential sensitivity of Phosphatidylinositol 3โ€“kinase p110ฮณ to isoforms of G protein ฮฒฮณ dimers
  2148. Epidermal growth factor stimulation of RPE cell survival: contribution of Phosphatidylinositol 3โ€“kinase and mitogen-activated protein kinase pathways
  2149. PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits Phosphatidylinositol 3โ€“kinase signaling and suppresses growth of solid tumors
  2150. Phosphatidylinositol 3โ€“kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation
  2151. Post-ischemic cardioprotection by A2A adenosine receptors: dependent of Phosphatidylinositol 3โ€“kinase pathway
  2152. Calorie restriction increases the ratio of Phosphatidylinositol 3โ€“kinase catalytic to regulatory subunits in rat skeletal muscle
  2153. nitric oxide triggers the Phosphatidylinositol 3โ€“kinase/Akt survival pathway in insulin-producing RINm5F cells by arousing Src to activate insulin receptor substrate-1
  2154. Phosphatidylinositol 3โ€“kinase regulates thymic exit
  2155. โ€ฆ Group A2 Potentiates Genotoxic Stress in Part through the Modulation of Basal and DNA Damageโ€“Dependent Phosphatidylinositol 3โ€“kinaseโ€“Related Protein kinase โ€ฆ
  2156. Dynamic reorganization of the astrocyte actin cytoskeleton elicited by cAMP and PACAP: a role for Phosphatidylinositol 3โ€kinase inhibition
  2157. Pulmonary surfactant protein A activates a Phosphatidylinositol 3โ€“kinase/calcium signal transduction pathway in human macrophages: participation in the up โ€ฆ
  2158. Novel mechanism of interaction of p85 subunit of Phosphatidylinositol 3โ€“kinase and ErbB3 receptor-derived phosphotyrosyl peptides
  2159. Role for the pleckstrin homology domain-containing protein CKIP-1 in Phosphatidylinositol 3โ€“kinase-regulated muscle differentiation
  2160. VEGF165 and angiopoietin-1 decreased myocardium infarct size through Phosphatidylinositolโ€“3 kinase and Bcl-2 pathways
  2161. Hypothalamic Phosphatidylinositol 3โ€kinaseโ€phosphodiesterase 3Bโ€cyclic AMP pathway of leptin signalling is impaired following chronic central leptin infusion
  2162. Akt2, Phosphatidylinositol 3โ€“kinase, and PTEN are in lipid rafts of intestinal cells: role in absorption and differentiation
  2163. CD40/CD40 homodimers are required for CD40-induced Phosphatidylinositol 3โ€“kinase-dependent expression of B7. 2 by human B lymphocytes
  2164. A permissive role for Phosphatidylinositol 3โ€“kinase in the Stat5-mediated expression of cyclin D2 by the interleukin-2 receptor
  2165. Epidermal growth factorโ€“induced cyclooxygenase-2 expression is mediated through Phosphatidylinositolโ€“3 kinase, not mitogen-activated protein/extracellular signal โ€ฆ
  2166. The Phosphatidylinositol 3โ€“kinase/protein kinase B signaling pathway is activated by lipoteichoic acid and plays a role in Kupffer cell production of interleukin-6 (IL-6) โ€ฆ
  2167. Differential regulation of Phosphatidylinositol 3โ€“kinase/Akt, mitogen-activated protein kinase, and AMP-activated protein kinase pathways during menadione-induced โ€ฆ
  2168. Mammary epithelial-mesenchymal interaction regulates fibronectin alternative splicing via Phosphatidylinositol 3โ€“kinase
  2169. Costimulation by CD137/4โ€“1BB inhibits Tโ€„cell apoptosis and induces Bclโ€xL and cโ€FLIPshort via Phosphatidylinositol 3โ€kinase and AKT/protein kinaseโ€„B
  2170. A specific antagonist of the p110ฮด catalytic component of Phosphatidylinositol 3โ€ฒ-kinase, IC486068, enhances radiation-induced tumor vascular destruction
  2171. The role of phospholipase C and Phosphatidylinositol 3โ€“kinase in vascular smooth muscle cell migration and proliferation
  2172. โ€ฆ hydroxy estradiol induces expression of hypoxia-inducible factor 1ฮฑ and vascular endothelial growth factor A through Phosphatidylinositol 3โ€“kinase/Akt/FRAP pathway โ€ฆ
  2173. โ€ฆ class I antibodies confers resistance to endothelial cells against antibody complementโ€mediated lysis by regulating Bad through the Phosphatidylinositol 3โ€kinase/Akt โ€ฆ
  2174. Calcium-sensing receptor induces proliferation through p38 mitogen-activated protein kinase and Phosphatidylinositol 3โ€“kinase but not extracellularly regulated โ€ฆ
  2175. SH2-B promotes insulin receptor substrate 1 (IRS1)-and IRS2-mediated activation of the Phosphatidylinositol 3โ€“kinase pathway in response to leptin
  2176. The mammalian target of rapamycin-p70 ribosomal S6 kinase but not Phosphatidylinositol 3โ€“kinase-Akt signaling is responsible for fibroblast growth factor-9 โ€ฆ
  2177. โ€ฆ -induced signaling pathway in endothelial cells resulting in the overexpression of vascular endothelial growth factor involves Ras and Phosphatidylinositol 3โ€“kinase
  2178. Low [Mg2+]e Enhances Arterial Spontaneous Tone via Phosphatidylinositol 3โ€“kinase in DOCA-Salt Hypertension
  2179. Inhibition of either Phosphatidylinositol 3โ€“kinase/Akt or the mitogen/extracellular-regulated kinase, MEK/ERK, signaling pathways suppress growth of breast cancer โ€ฆ
  2180. Phosphatidylinositol 3โ€“kinase (PI-3K)/Akt but not PI-3K/p70 S6 kinase signaling mediates IGF-1-promoted lens epithelial cell survival
  2181. โ€ฆ -ฮด12, 14-prostaglandin J2 inhibits the inflammatory response in primary rat astrocytes via down-regulating multiple steps in Phosphatidylinositol 3โ€“kinase-akt-NF-ฮบB โ€ฆ
  2182. The bile acid tauroursodeoxycholic acid modulates phosphorylation and translocation of bad via Phosphatidylinositol 3โ€“kinase in glutamate-induced apoptosis of rat โ€ฆ
  2183. Comparison of Phosphatidylinositolโ€“3โ€“kinase signalling within a panel of human colorectal cancer cell lines with mutant or wild-type PIK3CA
  2184. Gฮฑq inhibits cardiac L-type Ca2+ channels through Phosphatidylinositol 3โ€“kinase
  2185. The influence of Phosphatidylinositol 3โ€kinase/Akt pathway on the ischemic injury during rat liver graft preservation
  2186. โ€ฆ โ€stimulating factorโ€, or ILโ€3โ€dependent survival of macrophages, but not proliferation, requires the expression of p21Waf1 through the Phosphatidylinositol 3โ€kinase โ€ฆ
  2187. RhoA controls myoblast survival by inducing the Phosphatidylinositol 3โ€kinaseโ€Akt signaling pathway
  2188. Functional integrity of nuclear factor ฮบB, Phosphatidylinositol 3โ€ฒ-kinase, and mitogen-activated protein kinase signaling allows tumor necrosis factor ฮฑ-evoked Bcl-2 โ€ฆ
  2189. Phosphatidylinositol 3โ€“kinase, phosphoinositide-specific phospholipase-Cฮณ and protein kinase-C signal myelin phagocytosis mediated by complement receptor-3 โ€ฆ
  2190. M-CSF stimulated differentiation requires persistent MEK activity and MAPK phosphorylation independent of Grb2โ€“Sos association and Phosphatidylinositol 3โ€“kinase โ€ฆ
  2191. โ€ฆ Aminoimidazole-4-carboxamide riboside suppresses lipopolysaccharide-induced TNF-ฮฑ production through inhibition of Phosphatidylinositol 3โ€“kinase/Akt activation in โ€ฆ
  2192. Activation of nuclear factor kappa B by diesel exhaust particles in mouse epidermal cells through Phosphatidylinositol 3โ€“kinase/Akt signaling pathway
  2193. Phosphatidylinositol 3โ€“kinase is a determinant of responsiveness to B cell antigen receptor-mediated Epstein-Barr virus activation
  2194. Phosphatidylinositol 3โ€“kinase inhibitors reveal a unique mechanism of enhancing insulin secretion in 832/13 rat insulinoma cells
  2195. The integrin ฮฒ1 subunit transmembrane domain regulates Phosphatidylinositol 3โ€“kinase-dependent tyrosine phosphorylation of Crk-associated substrate
  2196. Integrin activation by bacterial fimbriae through a pathway involving CD14, Tollโ€like receptor 2, and Phosphatidylinositolโ€3โ€kinase
  2197. cAMP-stimulated Na+ transport in H441 distal lung epithelial cells: role of PKA, Phosphatidylinositol 3โ€“kinase, and sgk1
  2198. Roles of Phosphatidylinositol 3โ€ฒ-kinase and mammalian target of rapamycin/p70 ribosomal protein S6 kinase in K-Ras-mediated transformation of intestinal epithelial โ€ฆ
  2199. โ€ฆ regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the Phosphatidylinositol 3โ€“kinase โ€ฆ
  2200. โ€ฆ cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, Phosphatidylinositol 3โ€“kinase, Akt, c-Jun โ€ฆ
  2201. โ€ฆ Pathway Leads to Phosphorylation of Insulin Receptor Substrate-1 on Ser307 and Ser612 and Impairs the Phosphatidylinositol 3โ€“kinase/Akt/Mammalian Target of โ€ฆ
  2202. Phosphatidylinositol 3โ€“kinase inhibitors are a triple threat to ovarian cancer
  2203. Diosgenin induces hypoxia-inducible factor-1 activation and angiogenesis through estrogen receptor-related Phosphatidylinositol 3โ€“kinase/Akt and p38 mitogen โ€ฆ
  2204. Role of Phosphatidylinositol 3โ€“kinase-ฮณ in mediating lung neutrophil sequestration and vascular injury induced by E. coli sepsis
  2205. Aquaporin-2 is retrieved to the apical storage compartment via early endosomes and Phosphatidylinositol 3โ€“kinase-dependent pathway
  2206. Regulation of granulocyte apoptosis by Phosphatidylinositol 3โ€“kinase
  2207. โ€ฆ in human breast cancer cells does not rely on direct induction of mitogen-activated protein kinase/extracellularly regulated kinase or Phosphatidylinositol 3โ€“kinase
  2208. Phosphatidylinositol 3โ€“kinase-dependent signaling modulates taurochenodeoxycholic acid-induced liver injury and cholestasis in perfused rat livers
  2209. Control of cell size through phosphorylation of upstream binding factor 1 by nuclear Phosphatidylinositol 3โ€“kinase
  2210. Activation of Phosphatidylinositol 3โ€kinase and cโ€Junโ€Nโ€terminal kinase cascades enhances NFโ€ฮบBโ€dependent gene transcription in BCGโ€stimulated macrophages โ€ฆ
  2211. Mouse embryonic stem cells and preimplantation embryos require signaling through the Phosphatidylinositol 3โ€kinase pathway to suppress apoptosis
  2212. Opposing roles of endothelial and smooth muscle Phosphatidylinositol 3โ€“kinase in vasoconstriction: effects of rho-kinase and hypertension
  2213. โ€ฆ -independent activation of GABAergic neurotransmission and receptor-dependent nontranscriptional activation of Phosphatidylinositol 3โ€“kinase/protein kinase Akt โ€ฆ
  2214. Muscarinic M2 receptor stimulation of Cav1. 2b requires Phosphatidylinositol 3โ€“kinase, protein kinase C, and c-Src
  2215. Vav-dependent and vav-independent Phosphatidylinositol 3โ€“kinase activation in murine B cells determined by the nature of the stimulus
  2216. โ€ฆ of the heavy chain of tetanus toxin rescues cerebellar granule neurones from apoptotic death: involvement of Phosphatidylinositol 3โ€kinase and mitogenโ€activated โ€ฆ
  2217. Phosphatidylinositol 3โ€“kinase/Akt pathway mediates heme oxygenase-1 regulation by lipopolysaccharide.
  2218. Possible involvement of Phosphatidylinositol 3โ€“kinase/Akt pathway in insulin-like growth factor-I-induced alkaline phosphatase activity in osteoblasts
  2219. Deregulation of the Phosphatidylinositolโ€“3 kinase signaling cascade is associated with neurodegeneration in Npc1โˆ’/โˆ’ mouse brain
  2220. Hydrogen peroxide and epidermal growth factor activate Phosphatidylinositol 3โ€“kinase and increase sodium transport in A6 cell monolayers
  2221. Involvement of Phosphatidylinositol 3โ€“kinase and insulin-like growth factor-I in YXLST-mediated neuroprotection
  2222. Survivin contributes to the anti-apoptotic activities of transforming growth factor alpha in mouse blastocysts through Phosphatidylinositol 3โ€˜-kinase pathway
  2223. โ€ฆ inhibits ฮฒ-amyloid peptide (1-42)-mediated hippocampal neuronal apoptosis through activation of mitogen-activated protein kinase and Phosphatidylinositol 3โ€“kinase โ€ฆ
  2224. Phosphatidylinositol 3โ€kinase inhibition enhances human sperm motility and spermโ€“zona pellucida binding
  2225. Modulation of Phosphatidylinositol 3โ€“kinase signaling reduces intimal hyperplasia in aortocoronary saphenous vein grafts
  2226. ฮฑ1A-Adrenoceptors Activate Glucose Uptake in L6 Muscle Cells through a Phospholipase C-, Phosphatidylinositolโ€“3 kinase-, and Atypical Protein kinase C โ€ฆ
  2227. Differential effects of P2Y1 and P2Y12 nucleotide receptors on ERK1/ERK2 and Phosphatidylinositol 3โ€kinase signalling and cell proliferation in serumโ€deprived โ€ฆ
  2228. โ€ฆ via modulation of involucrin and transglutaminase expression through the integrin ฮฑ3ฮฒ1 and the Phosphatidylinositol 3โ€“kinase/Akt signaling pathway
  2229. Phosphatidylinositol 3โ€“kinase modulates vascular smooth muscle contraction by calcium and myosin light chain phosphorylation-independent and-dependent โ€ฆ
  2230. โ€ฆ -1 and HNF-4 and the coactivator p300 are involved in insulin-regulated glucokinase gene expression via the Phosphatidylinositol 3โ€“kinase/protein kinase B โ€ฆ
  2231. Mammalian target of rapamycin and 3โ€“Phosphatidylinositol 3โ€“kinase pathway inhibition enhances growth inhibition of transforming growth factor-ฮฒ1 in prostate cancer โ€ฆ
  2232. Fibroblast growth factor-2 induces osteoblast survival through a Phosphatidylinositol 3โ€“kinase-dependent,-ฮฒ-catenin-independent signaling pathway
  2233. Activation of MMP-2 in response to vascular injury is mediated by Phosphatidylinositol 3โ€“kinase-dependent expression of MT1-MMP
  2234. Adhesion-independent ฮฑ6ฮฒ4 integrin clustering is mediated by Phosphatidylinositol 3โ€“kinase
  2235. โ€ฆ -induced integrin affinity maturation promotes recruitment of ฮฑVฮฒ3 integrin to focal adhesions in endothelial cells: Evidence for a role of Phosphatidylinositol 3โ€“kinase โ€ฆ
  2236. NGF-induced Phosphatidylinositol 3โ€“kinase signaling pathway prevents thapsigargin-triggered ER stress-mediated apoptosis in PC12 cells
  2237. Optimal windows of statin use for immediate infarct limitation: 5โ€ฒ-nucleotidase as another downstream molecule of Phosphatidylinositol 3โ€“kinase
  2238. Complementation of human papillomavirus type 16 E6 and E7 by Jagged1-specific Notch1-Phosphatidylinositol 3โ€“kinase signaling involves pleiotropic oncogenic โ€ฆ
  2239. Phosphatidylinositol 3โ€“kinase activator reduces motor neuronal cell death induced by G93A or A4V mutant SOD1 gene
  2240. Transient Phosphatidylinositol 3โ€“kinase inhibition protects immature primary cortical neurons from oxidative toxicity via suppression of extracellular signal โ€ฆ
  2241. Exogenous tissue inhibitor of metalloproteinaseโ€1 promotes endothelial cell survival through activation of the Phosphatidylinositol 3โ€kinase/Akt pathway
  2242. Phosphatidylinositol 3โ€“kinase activation is required for sulfonylurea stimulation of glucose transport in rat skeletal muscle
  2243. Enhancement of osteopontin expression in HepG2 cells by epidermal growth factor via Phosphatidylinositol 3โ€“kinase signaling pathway
  2244. Cloning of Brassica napus phospholipase C2 (BnPLC2), Phosphatidylinositol 3โ€“kinase (BnVPS34) and Phosphatidylinositol synthase1 (BnPtdIns S1)โ€”comparative โ€ฆ
  2245. Biochemical and biological responses induced by coupling of Gab1 to Phosphatidylinositol 3โ€“kinase in RET-expressing cells
  2246. โ€ฆ receptor ฮฒ/ฮด (PPARฮฒ/ฮด) increases the expression of prostaglandin E2 receptor subtype EP4: the roles of Phosphatidylinositol 3โ€“kinase and CCAAT/enhancer โ€ฆ
  2247. Phosphatidylinositol 3โ€“kinase p85ฮฑ subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological โ€ฆ
  2248. ฮฑ-Thrombin-mediated Phosphatidylinositol 3โ€“kinase activation through release of Gฮฒฮณ dimers from Gฮฑq and Gฮฑi2
  2249. Angiotensin II Regulation of the Na+ Pump Involves the Phosphatidylinositolโ€“3 kinase and p42/44 Mitogen-Activated Protein kinase Signaling Pathways in Vascular โ€ฆ
  2250. Resensitization of P2Y Receptors by Growth Factorโ€“Mediated Activation of the Phosphatidylinositolโ€“3 kinase in Retinal Glial Cells
  2251. Upregulated function of Phosphatidylinositolโ€3โ€kinase in genetically hypertensive rats: a moderator of arterial hypercontractility
  2252. Adenosine A2A receptor facilitates calcium-dependent protein secretion through the activation of protein kinase A and Phosphatidylinositolโ€“3 kinase in PC12 cells
  2253. โ€ฆ , a diterpenoid triepoxide, induces antitumor proliferation via activation of c-Jun NH2-terminal kinase 1 by decreasing Phosphatidylinositol 3โ€“kinase activity in human โ€ฆ
  2254. Leptin decreases renal medullary Na (+), K (+)-ATPase activity through Phosphatidylinositol 3โ€“kinase dependent mechanism.
  2255. Differential involvement of Phosphatidylinositol 3โ€“kinase and p42/p44 mitogen activated protein kinase pathways in brain-derived neurotrophic factor-induced trophic โ€ฆ
  2256. โ€ฆ epidermal growth factorโ€like growth factor stimulates cell proliferation in cerebral cortical cultures through Phosphatidylinositol 3โ€ฒโ€kinase and mitogenโ€activated โ€ฆ
  2257. Two distinct regulatory mechanisms of neurotransmitter release by Phosphatidylinositol 3โ€kinase
  2258. AND-34 Activates Phosphatidylinositol 3โ€“kinase and Induces Anti-Estrogen Resistance in a SH2 and GDP Exchange Factorโ€“Like Domain-Dependent Manner
  2259. Calcium oscillation and Phosphatidylinositol 3โ€“kinase positively regulate integrin ฮฑIIbฮฒ3-mediated outside-in signaling
  2260. Overexpression of the N-terminal end of the p55ฮณ regulatory subunit of Phosphatidylinositol 3โ€“kinase blocks cell cycle progression in gastric carcinoma cells
  2261. Inhibition of Phosphatidylinositolโ€“3โ€“kinase synergizes with gemcitabine in low-passage tumor cell lines correlating with Bax translocation to the mitochondria
  2262. โ€ฆ neurones by brainโ€derived neurotrophic factor and Rafโ€1 protein kinase: role of extracellular signalโ€regulated protein kinase and Phosphatidylinositol 3โ€kinase
  2263. Phosphatidylinositolโ€“3โ€“kinase activation mediates proline-rich tyrosine kinase 2 phosphorylation and recruitment to ฮฒ1-integrins in human CD34+ cells
  2264. Angiopoietin-1 attenuates H2O2-induced SEK1/JNK phosphorylation through the Phosphatidylinositol 3โ€“kinase/Akt pathway in vascular endothelial cells
  2265. RNA interference, A potential strategy for isoform-specific Phosphatidylinositol 3โ€“kinase targeted therapy in ovarian cancer
  2266. Expression of insulin receptor substrates 1-3, glucose transporters GLUT-1-4, signal regulatory protein 1ฮฑ, Phosphatidylinositol 3โ€“kinase and protein kinase B at the โ€ฆ
  2267. Phosphatidylinositol 3โ€“kinase regulates Ca2+ signaling in pancreatic acinar cells through inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase
  2268. In vitro metabolism of the Phosphatidylinositol 3โ€“kinase inhibitor, wortmannin, by carbonyl reductase
  2269. Interleukin-2-induced survival of natural killer (NK) cells involving Phosphatidylinositolโ€“3 kinase-dependent reduction of ceramide through acid sphingomyelinase โ€ฆ
  2270. T cell leukemia-1 modulates TCR signal strength and IFN-ฮณ levels through Phosphatidylinositol 3โ€“kinase and protein kinase C pathway activation
  2271. Adenosine A3 receptor-mediated regulation of p38 and extracellular-regulated kinase ERK1/2 via Phosphatidylinositolโ€“3โ€ฒ-kinase
  2272. Negative Feedback Regulation of Phosphatidylinositol 3โ€kinase/Akt Pathway by Overโ€Expressed Cyclooxygenaseโ€2 in Human Epidermal Cancer Cells
  2273. Group IB secretory phospholipase A2 promotes matrix metalloproteinase-2-mediated cell migration via the Phosphatidylinositol 3โ€“kinase and Akt pathway
  2274. Phosphatidylinositol 3โ€“kinase/Akt-dependent and-independent protection against apoptosis in normal human melanocytes
  2275. Generation and functional in vivo characterization of a lipid kinase defective Phosphatidylinositol 3โ€“kinase Vps34p of Candida albicans
  2276. Phosphatidylinositolโ€3 kinase inhibitors reproduce the selective antiproliferative effects of imatinib on chronic myeloid leukaemia progenitor cells
  2277. โ€ฆ adhesion is controlled by src-kinases, whereas PF-4โ€“mediated exocytosis requires the additional activation of p38 MAP kinase and Phosphatidylinositol 3โ€“kinase
  2278. Prolactin and heregulin override DNA damage-induced growth arrest and promote Phosphatidylinositolโ€“3 kinase-dependent proliferation in breast cancer cells
  2279. Hemangiopoietin inhibits apoptosis of MO7e leukemia cells through Phosphatidylinositol 3โ€“kinaseโ€“AKT pathway
  2280. Intrinsic regulation of the interactions between the SH3 domain of p85 subunit of Phosphatidylinositolโ€“3 kinase and the protein network of BCR/ABL oncogenic โ€ฆ
  2281. Akt-dependent cell size regulation by the adhesion molecule on glia occurs independently of Phosphatidylinositol 3โ€“kinase and Rheb signaling
  2282. Phosphatidylinositol 3โ€“kinase regulates early differentiation in human laryngeal keratinocytes
  2283. Raloxifene improves coronary perfusion, cardiac contractility, and myocardial metabolism in the ischemic heart: role of Phosphatidylinositol 3โ€“kinase/Akt pathway
  2284. Arrest of human lung fibroblasts in G2 phase after irradiation is regulated by converging Phosphatidylinositolโ€“3 kinase and ฮฒ1-integrin signaling in vitro
  2285. โ€ฆ M stimulation of proliferation of prostate cancer 22Rv1 cells through the signaling pathways of p38 mitogenโ€activated protein kinase and Phosphatidylinositol 3โ€kinase
  2286. โ€ฆ of the insulin-like growth factor-I receptor by angiotensin II mediates downstream signaling from the angiotensin II type 1 receptor to Phosphatidylinositol 3โ€“kinase
  2287. Skeletal muscle insulin signaling defects downstream of Phosphatidylinositol 3โ€“kinase at the level of Akt are associated with impaired nonoxidative glucose disposal in โ€ฆ
  2288. โ€ฆ interleukin-1 receptor-associated kinase degradation in response to lipopolysaccharide: involvement of CD14/TLR4, CR3, and Phosphatidylinositol 3โ€“kinase
  2289. Constitutively activated Phosphatidylinositol 3โ€“kinase primes platelets from patients with chronic myelogenous leukemia for thrombopoietin-induced aggregation
  2290. Enhanced v-Src-induced oncogenic transformation in the absence of focal adhesion kinase is mediated by Phosphatidylinositol 3โ€“kinase
  2291. Phosphorylation of glycosyl-Phosphatidylinositol by Phosphatidylinositol 3โ€“kinase changes its properties as a substrate for phospholipases
  2292. Kainate mediates nuclear factor-kappa B activation in hippocampus via Phosphatidylinositolโ€“3 kinase and extracellular signal-regulated protein kinase
  2293. โ€ฆ apoptosis by GMโ€CSF as a result of temporary suppression of FADD recruitment in neutrophils: evidence implicating Phosphatidylinositol 3โ€kinase and MEK1โ€ERK1 โ€ฆ
  2294. Balamuthia mandrillaris stimulates interleukin-6 release in primary human brain microvascular endothelial cells via a Phosphatidylinositol 3โ€“kinase-dependent โ€ฆ
  2295. Suppression of a Phosphatidylinositol 3โ€“kinase signal by a specific spliced variant of Drosophila PTEN
  2296. Phosphatidylinositol 3โ€“kinase-dependent mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 and NF-ฮบB signaling pathways are required for B โ€ฆ
  2297. โ€ฆ by granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor ฮฑ: role of Phosphatidylinositol 3โ€“kinase
  2298. Direct activation of telomerase by GH via Phosphatidylinositol 3โ€ฒ-kinase
  2299. The production of IL-1 receptor antagonist in IFN-ฮฒ-stimulated human monocytes depends on the activation of Phosphatidylinositol 3โ€“kinase but not of STAT1
  2300. Defective Activation of Protein kinase Cz in Muscle by Insulin and Phosphatidylinositolโ€“3,4,5,-(PO4)3 in Obesity and Polycystic Ovary Syndrome
  2301. LY303511 (2-piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via Phosphatidylinositol 3โ€“kinase-independent pathways to inhibit cell proliferation via mammalian โ€ฆ
  2302. Carbamazepine enhances the activity of glutamate transporter type 3 via Phosphatidylinositol 3โ€“kinase
  2303. Inhibition of Phosphatidylinositol 3โ€“kinase/Protein kinase B Signaling Is Not Sufficient to Account for Indole-3-Carbinolโ€“Induced Apoptosis in Some Breast and โ€ฆ
  2304. Phosphatidylinositol 3โ€“kinase VPS34 of Candida albicans is involved in filamentous growth, secretion of aspartic proteases, and intracellular detoxification
  2305. โ€ฆ epidermal growth factor-like growth factor inhibits cytokine-induced NF-ฮบB activation and nitric oxide production via activation of the Phosphatidylinositol 3โ€“kinase โ€ฆ
  2306. โ€ฆ of ovarian insulin-like growth factor-binding protein-3 transcription requires a TATA box-binding protein and the protein kinase A and Phosphatidylinositolโ€“3 kinase โ€ฆ
  2307. CD4+ CD25+ regulatory T cells attenuate the Phosphatidylinositol 3โ€“kinase/Akt pathway in antigen-primed immature CD8+ CTLs during functional maturation
  2308. B cell receptor (BCR) cross-talk: IL-4 creates an alternate pathway for BCR-induced ERK activation that is Phosphatidylinositol 3โ€“kinase independent
  2309. Oxidized lowโ€density lipoproteinโ€induced apoptosis is attenuated by insulinโ€activated Phosphatidylinositol 3โ€kinase/Akt through p38 mitogenโ€activated protein kinase
  2310. โ€ฆ signaling by the novel compound 3-Cl-AHPC involves increased EGFR proteolysis and accompanying decreased Phosphatidylinositol 3โ€“kinase and AKT kinase โ€ฆ
  2311. Growth factors change nuclear distribution of estrogen receptor-ฮฑ via mitogen-activated protein kinase or Phosphatidylinositol 3โ€“kinase cascade in a human breast โ€ฆ
  2312. Protein kinase C modulates negatively the hepatocyte growth factor-induced migration, integrin expression and Phosphatidylinositol 3โ€“kinase activation
  2313. LY294002 inhibits monocyte chemoattractant protein-1 expression through a Phosphatidylinositol 3โ€“kinase-independent mechanism
  2314. Phosphatidylinositolโ€“3โ€“kinase regulates PKCฮธ activity in cytotoxic T cells
  2315. Assay and Stimulation of the Rab5 GTPase by the p85ฮฑ Subunit of Phosphatidylinositol 3โ€kinase
  2316. โ€ฆ -like growth factor (IGF) binding protein-3 synthesis by IGF-I and transforming growth factor-ฮฑ is mediated by both Phosphatidylinositolโ€“3 kinase and mitogen-activated โ€ฆ
  2317. โ€ฆ phospholipase D pathway stimulated by formyl-methionyl-leucyl-phenylalanine in human neutrophils. Involvement of EP2 receptors and Phosphatidylinositol 3โ€“kinase โ€ฆ
  2318. Integrated pharmacological preconditioning and memory of cardioprotection: role of protein kinase C and Phosphatidylinositol 3โ€“kinase
  2319. Requirements for pYXXM motifs in Cbl for binding to the p85 subunit of Phosphatidylinositol 3โ€“kinase and Crk, and activation of atypical protein kinase C and glucose โ€ฆ
  2320. Hedamycin, a DNA alkylator, induces ฮณH2AX and chromosome aberrations: Involvement of Phosphatidylinositol 3โ€“kinaseโ€“related kinases and DNA replication fork โ€ฆ
  2321. Insulin-like growth factor binding protein-3 stimulates Phosphatidylinositol 3โ€“kinase in MCF-7 breast carcinoma cells
  2322. Measurement of the Interaction of the p85ฮฑ Subunit of Phosphatidylinositol 3โ€kinase with Rab5
  2323. Role of the Phosphatidylinositol 3โ€“kinase and mitogen-activated protein kinase pathways in the secretion of tumor necrosis factor-ฮฑ and interleukin-10 by the PPD โ€ฆ
  2324. Possible involvement of Phosphatidylinositol 3โ€“kinase/Akt signal pathway in vasopressin-induced HSP27 phosphorylation in aortic smooth muscle A10 cells
  2325. Inhibition of Phosphatidylinositolโ€“3โ€“kinase causes cell death through a protein kinase B (PKB)-dependent mechanism and growth arrest through a PKB-independent โ€ฆ
  2326. Leptin regulates insulin sensitivity via Phosphatidylinositolโ€“3-OH kinase signaling in mediobasal hypothalamic neurons
  2327. CD40-dependent activation of Phosphatidylinositol 3โ€“kinase/AKT pathway inhibits apoptosis of human cultured mesangial cells induced by oxidized LDL
  2328. Differential regulation of the regulatory subunits for Phosphatidylinositol 3โ€“kinase in response to motor nerve injury
  2329. Nerve growth factor restores p53 function in pituitary tumor cell lines via trkA-mediated activation of Phosphatidylinositol 3โ€“kinase
  2330. Ethanol impairs insulinโ€™s actions through Phosphatidylinositol 3โ€“kinase
  2331. Alterations in lens protein tyrosine phosphorylation and Phosphatidylinositol 3โ€“kinase signaling during selenite cataract formation
  2332. Activation of Phosphatidylinositol 3โ€“kinase-protein kinase B (PI3K-PKB) induced by 17beta-estradiol in endometrial carcinoma cell (Ishikawa)
  2333. Phosphatidylinositol 3โ€kinase is required for the transcriptional activation of cyclin D2 in BCR activated primary mouse B lymphocytes
  2334. โ€ฆ factor mediates Porphyromonas gingivalis lipopolysaccharide interference with salivary mucin synthesis via Phosphatidylinositol 3โ€“kinase-dependent constitutive nitric โ€ฆ
  2335. โ€ฆ blue 2 inhibition of cyclic AMP-dependent differentiation of rat C6 glioma cells by purinergic receptor-independent inactivation of Phosphatidylinositol 3โ€“kinase
  2336. โ€ฆ -like protein tyrosine phosphatase ฮฑ, Src, and Rho to increase prolactin gene expression through a final Phosphatidylinositol 3โ€“kinase/cytoskeletal pathway that is โ€ฆ
  2337. Insulin-like growth factor I induces preferential degradation of insulin receptor substrate-2 through the Phosphatidylinositol 3โ€“kinase pathway in human neuroblastoma โ€ฆ
  2338. Inhibition of Phosphatidylinositolโ€“3โ€“kinase Enhances Insulin Stimulation of Insulin Receptor Substrate 1 Tyrosine Phosphorylation and Extracellular Signal-Regulated โ€ฆ
  2339. Angiopoietin-1 reduces iopromide-induced endothelial cell apoptosis through activation of Phosphatidylinositol 3โ€˜-kinase/p70 S6 kinase.
  2340. Insulin substrates 1 and 2 are corequired for activation of atypical protein kinase C and Cbl-dependent Phosphatidylinositol 3โ€“kinase during insulin action in โ€ฆ
  2341. The Phosphatidylinositol 3โ€“kinase Vps34p of the human pathogenic yeast Candida albicans is a multifunctional protein that interacts with the putative vacuolar H+ โ€ฆ
  2342. Phosphatidylinositol 3โ€kinase and ERK1/2 are not involved in adenosine A1, A2A or A3 receptorโ€mediated preconditioning in rat ventricle strips
  2343. โ€ฆ activated receptor/(PPAR/) increases the expression of prostaglandin E2 receptor subtype EP4: the roles of Phosphatidylinositol 3โ€“kinase and CCAAT/enhancer โ€ฆ
  2344. Impaired Activation of Protein kinase C-ฮถ by Insulin and Phosphatidylinositolโ€“3,4,5-(PO4)3 in Cultured Preadipocyte-Derived Adipocytes and Myotubes of Obese โ€ฆ
  2345. A constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a Phosphatidylinositolโ€“3-OH-kinase-, cAMP-dependent โ€ฆ
  2346. The role of Phosphatidylinositolโ€“3 kinase in vanadate-promoted S phase entry
  2347. Phosphatidylinositol 3โ€“kinase, phosphoinositides and apoptosis
  2348. ALCOHOLIC PANCREATIC FIBROSIS: ROLE OF THE Phosphatidylinositolโ€“3 kinase (PI3-K) AND PROTEIN kinase C (PKC) PATHWAYS IN PANCREATIC โ€ฆ
  2349. Role of Phosphatidylinositolโ€“3 kinase in regulation of differential sensitivity of melanoma cells to antitumor agents. A model for hormone resistance development in โ€ฆ
  2350. Differential Effects of Three Small Molecules Blocking Phosphatidylinositolโ€“3 kinase or AKT in Hodgkin Disease Cell Lines: Induction of Apoptosis and Cell Cycle โ€ฆ
  2351. Role of Phosphatidylinositolโ€“3โ€“kinase and protein kinase Cฮถ in the adenylate cyclase signal mechanism of action of relaxin in muscle tissues of rats and mollusks
  2352. Novel expression patterns of Phosphatidylinositol 3โ€hydroxy kinase in nodulated Medicago spp. plants
  2353. Adrenomedullin infusion attenuates myocardial ischemia/reperfusion injury through the Phosphatidylinositol 3โ€“kinase/Akt-dependent pathway
  2354. Activation of the hexosamine pathway leads to phosphorylation of IRS-1 on Ser307 and Ser612 and impairs the Phosphatidylinositol 3โ€“kinase/Akt/mTOR insulin โ€ฆ
  2355. Enhancement of susceptibility to Fas-mediated apoptosis in HL-60 cells through down-regulation of cellular FLICE-inhibitory protein by Phosphatidylinositol 3โ€“kinase โ€ฆ
  2356. Role of extracellular signalโ€regulated protein kinase and Phosphatidylinositol 3โ€kinase in neuronal cell death and survival
  2357. Inhibition of Phosphatidylinositol 3โ€“kinase activity blocks nuclear accumulation of protein kinase zetta during granulocytic differentiation of HL-60 cells
  2358. Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires Phosphatidylinositol 3-OH-kinase signaling
  2359. Physiological role of Vps34 Phosphatidylinositol 3โ€“kinase in mammalian cells
  2360. Inhibition of Phosphatidylinositol 3โ€“kinase causes apoptosis in retinoic acid-differentiated HL-60 leukemia cells
  2361. Phosphatidylinositol 3โ€“kinase (PI3K) cascade is a novel signaling pathway to mediate inflammatory pain
  2362. Activation of the Phosphatidylinositolโ€“3โ€˜kinase pathway and DNA synthesis by a mutant insulin-like growth factor I receptor lacking the NPXY motif
  2363. Estrogen receptor (ER) ฮฑ and ERฮฒ are both expressed in human ejaculated spermatozoa: evidence of their direct interaction with Phosphatidylinositolโ€“3-OH kinase/Akt โ€ฆ
  2364. A novel Phosphatidylinositol 3โ€“kinase inhibitor, ZSTK474 exerted antitumor activity against human tumor xenografts by oral administration
  2365. Roles of Akt2 and the molecular balance of Phosphatidylinositol 3โ€“kinase subunits in enhanced skeletal muscle insulin sensitivity with calorie restriction
  2366. Activation of Phosphatidylinositol 3โ€“kinase, Akt and Mammalian Target of Rapamycin (mTOR) Is Necessary for Hypoxia-Induced Pulmonary Artery Adventitial โ€ฆ
  2367. Role of Phosphatidylinositol 3โ€“kinase/AKT Pathway in Diffuse Large B-Cell Lymphoma Survival.
  2368. Research Capsule Phosphatidylinositol 3โ€“kinase: A Novel Effector
  2369. Role of Phosphatidylinositol 3โ€“kinase in platelet aggregation in type 1 diabetes mellitus
  2370. Role of Phosphatidylinositol 3โ€“kinase in oxidative stress-induced disruption of tight junctions. Vol. 278 (2003) 49239-49245
  2371. Phosphatidylinositol 3โ€“kinase p85 Subunit-Dependent Interaction with BCR/ABL: Molecular Mechanism and Biological Consequences.
  2372. Oxygen, hypoxia-inducible factors, and Phosphatidylinositol 3โ€“kinase/Akt signaling in tumor growth and gene expression.
  2373. Atypical Protein kinase C (PKCฮป/ฮถ) is a convergent downstream target of the insulin stimulated Phosphatidylinositol 3โ€“kinase and TC10 signalling pathways
  2374. Type I Transforming Growth Factor ูƒ Receptor Binds to and Activates Phosphatidylinositol 3โ€“kinase
  2375. Specific Inhibition of p110ฮด Catalytic Subunit of Phosphatidylinositol 3โ€˜-kinase With IC489666 Radiosensitizes Vascular Endothelium to Provide Improved Tumor โ€ฆ
  2376. Phosphatidylinositol 3โ€“kinase activator reduces motor neuronal cell death induced by G93A or A4V mutant SOD1 gene
  2377. Expression and significance of Phosphatidylinositol 3โ€“kinase in mammary atypical ductal hyperrlasia and cance
  2378. Augmentation in inhibitory effect of sodium butyrate by Phosphatidylinositol 3โ€“kinase inhibition in the human cervical cancer cells
  2379. Role of Phosphatidylinositol 3โ€“kinase in epinephrine and calcium ionophore, A 23187 induced platelet aggregation
  2380. THE ROLE OF Phosphatidylinositol 3 kinase IN THE INDUCTION OF LIPOPOLYSACCHARIDE TOLERANCE AND PRIMING TOSTAPHYLOCOCCUS โ€ฆ
  2381. UV-B Induced stimulation of Phosphatidylinositol 3โ€“kinase in human fetal hepatocytes
  2382. The Association of the Phosphatidylinositolโ€“3โ€“kinase Pathway to Gleason Score, Prostate-specific Antigen and Pathologic Stage in Prostate Cancer
  2383. Bacterial Endotoxin and Staphylococcus aureus induced Tolerance and Priming, Implication of the Phosphatidylinositolโ€“3 kinase Pathway: 262
  2384. Overexpression of the N-terminal end of the p55y regulatory subunit of Phosphatidylinositol 3โ€“kinase blocks cell cycle progression in gastric carcinoma cells
  2385. Phosphatidylinositol 3โ€“kinase and Protein kinase C as Molecular Determinants of Chemoresistance in Breast Cancer
  2386. Nicotinic Receptor Stimulation Blocks Neurotoxicity Induced by Amyloid-รŸ via the Phosphatidylinositolโ€“3โ€“kinase Cascade
  2387. โ€ฆ OF OOCYTES, SPERM-OOCYTE INTERACTIONS AND EARLY CLEAVAGE OF EMBRYOS IN MICE, ROLE OF Phosphatidylinositol 3โ€“kinase, MOS, FAS-FAS โ€ฆ
  2388. P-selectin activates leukocyte integrin alphaMbeta2 by recruiting Phosphatidylinositolโ€“3 kinase to p-selectin glycoprotein ligand-1 cytoplasmic domain through adaptor โ€ฆ
  2389. Mycobacteria-induced Interleukin-12 Expression by Human Monocyte-derived Macrophages Is Negatively Regulated by Phosphatidylinositol 3โ€“kinase and ERK 1/2 โ€ฆ
  2390. โ€ฆ โ€, or ILโ€3โ€dependent survival of macrophages, but not proliferation, requires the expression of p21Waf1 through the Phosphatidylinositol 3โ€kinase/Akt pathway (Vol โ€ฆ
  2391. Analysis of IRS-1-mediated Phosphatidylinositol 3โ€“kinase activation in the adipose tissue of polycystic ovary syndrome patients complicated with insulin resistance
  2392. Stretch-induced retinal vascular endothelial growth factor expression is mediated by Phosphatidylinositol 3โ€“kinase and protein kinase C (PKC)-ฮถ but not by stretch โ€ฆ
  2393. 459 EFFECT OF INSULIN ON ADIPONECTIN SECRETION FROM 3T3-L1 ADIPOCYTES IS Phosphatidylinositol 3โ€“kinase DEPENDENT
  2394. โ€ฆ apoptosis by GM-CSF as a result of temporary suppression of FADD recruitment in neutrophils: evidence implicating Phosphatidylinositol 3โ€“kinase and MEK1-ERK1/2 โ€ฆ
  2395. Relationship between neuroprotective effect of 17# beta#โ€“estradiol and activity of Phosphatidylinositolโ€”3โ€”kinase
  2396. โ€ฆ by GM-CSF as a result of temporary suppression of FADD recruitment in neutrophils: evidence implicating Phosphatidylinositol 3โ€“kinase and MEK1-ERK1/2 โ€ฆ
  2397. S 2-24: A protein kinase C superfamily member mediates invasive prostate cell growth downstream of activated Phosphatidylinositol 3โ€“kinase
  2398. โ€ฆ stress protection and increased cell proliferation induced by the protein p8 in INS-1 beta cells via activation of the Phosphatidylinositolโ€“3โ€˜-kinase and MAP kinase โ€ฆ
  2399. AND-34-induced Rac activation and antiestrogen resistance in breast cancer requires Phosphatidylinositol 3โ€“kinase
  2400. The inhibitory effect of dibutyryl cyclic AMP on docosahexaenoic acid-induced apoptosis in HL-60 cells through activation of the Phosphatidylinositolโ€“3 kinase pathway
  2401. Cripto-1 Inhibits-Casein Expression in Mammary Epithelial Cells through a p21โ€ฒ-and Phosphatidylinositol 3โ€˜-kinase-dependent Pathway1
  2402. โ€ฆ Factor 1 Induced Expression of Vascular Endothelial Growth Factor, Which Is Dependent on MAP kinase and Phosphatidylinositol 3โ€“kinase Signaling in Human โ€ฆ
  2403. โ€ฆ -Induced Vascular Endothelial Growth Factor in Human Bone Marrow Stromal Cells, Which Is Involved in MAP kinase and Phosphatidylinositol 3โ€“kinase โ€ฆ
  2404. Study of the regulation of Fab1p, a Phosphatidylinositol 3-phosphate 5 kinase in Saccharomyces cerevisiae
  2405. Characterisation of the Phosphatidylinositolโ€“3-phosphate 5-kinase, Fab1, in Drosophila melanogaster
  2406. Phosphatidylinositol 3โ€kinase inhibitors: promising drug candidates for cancer therapy
  2407. Cancer-specific mutations in Phosphatidylinositol 3โ€“kinase
  2408. Antitumor activity of ZSTK474, a new Phosphatidylinositol 3โ€“kinase inhibitor
  2409. Therapeutic potential of Phosphatidylinositol 3โ€“kinase inhibitors in inflammatory respiratory disease
  2410. Phosphatidylinositol 3โ€“kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/Phosphatidylinositol 3โ€“kinase inhibitor NVP-BEZ235
  2411. Genetic alterations and their relationship in the Phosphatidylinositol 3โ€“kinase/Akt pathway in thyroid cancer
  2412. ZSTK474 is an ATPโ€competitive inhibitor of class I Phosphatidylinositol 3 kinase isoforms
  2413. Helical domain and kinase domain mutations in p110ฮฑ of Phosphatidylinositol 3โ€“kinase induce gain of function by different mechanisms
  2414. Effect of the Phosphatidylinositol 3โ€“kinase/Akt pathway on influenza A virus propagation
  2415. Role of Phosphatidylinositol 3โ€ฒ-kinase/AKT pathway in diffuse large B-cell lymphoma survival
  2416. Beclin 1 forms two distinct Phosphatidylinositol 3โ€“kinase complexes with mammalian Atg14 and UVRAG
  2417. Assortment of Phosphatidylinositol 3โ€“kinase complexesโ€”Atg14p directs association of complex I to the pre-autophagosomal structure in Saccharomyces cerevisiae
  2418. Bivalent role of the Phosphatidylinositolโ€3โ€kinase (PI3K) during influenza virus infection and host cell defence
  2419. Roles of Phosphatidylinositol 3โ€“kinase in root hair growth
  2420. Role of Phosphatidylinositol 3โ€“kinase activation on insulin action and its alteration in diabetic conditions
  2421. The Arabidopsis Phosphatidylinositol 3โ€“kinase is important for pollen development
  2422. Artery/vein specification is governed by opposing Phosphatidylinositolโ€“3 kinase and MAP kinase/ERK signaling
  2423. Cross-talk between the androgen receptor and the Phosphatidylinositol 3โ€“kinase/Akt pathway in prostate cancer
  2424. Targeting the Phosphatidylinositol 3โ€“kinase pathway in multiple myeloma
  2425. Clusterin activates survival through the Phosphatidylinositol 3โ€“kinase/Akt pathway
  2426. Phosphatidylinositol 3โ€“kinase inhibition by LY294002 radiosensitizes human cervical cancer cell lines
  2427. Regulation of hepatitis B virus replication by the Phosphatidylinositol 3โ€“kinase-akt signal transduction pathway
  2428. Cytokine stimulation promotes glucose uptake via Phosphatidylinositolโ€“3 kinase/Akt regulation of Glut1 activity and trafficking
  2429. Nutrients suppress Phosphatidylinositol 3โ€“kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation
  2430. Activation of endothelial nitric oxide synthase by cilostazol via a cAMP/protein kinase A-and Phosphatidylinositol 3โ€“kinase/Akt-dependent mechanism
  2431. Regulation of class-switch recombination and plasma cell differentiation by Phosphatidylinositol 3โ€“kinase signaling
  2432. Differential association of Phosphatidylinositol 3โ€“kinase, SHIP-1, and PTEN with forming phagosomes
  2433. The Phosphatidylinositol 3โ€“kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures
  2434. Identification and characterization of NVP-BEZ235, a new orally available dual Phosphatidylinositol 3โ€“kinase/mammalian target of rapamycin inhibitor with potent in โ€ฆ
  2435. Dual regulatory roles of Phosphatidylinositol 3โ€“kinase in IFN signaling
  2436. High prevalence and mutual exclusivity of genetic alterations in the Phosphatidylinositolโ€“3โ€“kinase/akt pathway in thyroid tumors
  2437. Activation of Phosphatidylinositol 3โ€“kinase signaling by a mutant thyroid hormone ฮฒ receptor
  2438. Influenza A virus NS1 protein binds p85ฮฒ and activates Phosphatidylinositolโ€“3โ€“kinase signaling
  2439. Phosphatidylinositol 3โ€“kinase/akt and ras/raf-mitogen-activated protein kinase pathway mutations in anaplastic thyroid cancer
  2440. Chronic kidney disease causes defects in signaling through the insulin receptor substrate/Phosphatidylinositol 3โ€“kinase/Akt pathway: implications for muscle atrophy
  2441. Hsp27 inhibits Bax activation and apoptosis via a Phosphatidylinositol 3โ€“kinase-dependent mechanism
  2442. Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of Phosphatidylinositol 3โ€“kinase, Akt, and AS160
  2443. PIK3CA cooperates with other Phosphatidylinositol 3โ€ฒ-kinase pathway mutations to effect oncogenic transformation
  2444. Inhibition of Phosphatidylinositol 3โ€“kinase Increases Efficacy of Cisplatin in in Vivo Ovarian Cancer Models
  2445. Phosphatidylinositol 3โ€ฒ-kinase/AKT Signaling Is Activated in Medulloblastoma Cell Proliferation and Is Associated with Reduced Expression of PTEN
  2446. Dysregulation of the Phosphatidylinositol 3โ€“kinase pathway in thyroid neoplasia
  2447. Inhibition of the Phosphatidylinositolโ€3 kinase/Akt promotes G1 cell cycle arrest and apoptosis in Hodgkin lymphoma
  2448. Association of PTEN gene methylation with genetic alterations in the Phosphatidylinositol 3โ€kinase/AKT signaling pathway in thyroid tumors
  2449. Integrative Genomic Analysis of Phosphatidylinositol 3โ€ฒ-kinase Family Identifies PIK3R3 as a Potential Therapeutic Target in Epithelial Ovarian Cancer
  2450. Influenza A virus NS1 protein activates the Phosphatidylinositol 3โ€“kinase (PI3K)/Akt pathway by direct interaction with the p85 subunit of PI3K
  2451. Antigen receptorโ€“mediated changes in glucose metabolism in B lymphocytes: role of Phosphatidylinositol 3โ€“kinase signaling in the glycolytic control of growth
  2452. Phosphatidylinositol 3โ€“kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell โ€ฆ
  2453. Erythropoietin involves the Phosphatidylinositol 3โ€kinase pathway, 14โ€3โ€3 protein and FOXO3a nuclear trafficking to preserve endothelial cell integrity
  2454. Phosphatidylinositol 3โ€“kinase is a key mediator of central sensitization in painful inflammatory conditions
  2455. Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase/Phosphatidylinositol 3โ€“kinase-Akt pathways and up โ€ฆ
  2456. Activation of the Phosphatidylinositol 3โ€“kinase Vps34 by a G protein ฮฑ subunit at the endosome
  2457. Hypoxic regulation of vascular endothelial growth factor through the induction of Phosphatidylinositol 3โ€“kinase/Rho/ROCK and c-Myc
  2458. Oxidative stress stimulates skeletal muscle glucose uptake through a Phosphatidylinositol 3โ€“kinase-dependent pathway
  2459. Frequent PTEN genomic alterations and activated Phosphatidylinositol 3โ€“kinase pathway in basal-like breast cancer cells
  2460. Isoginkgetin inhibits tumor cell invasion by regulating Phosphatidylinositol 3โ€“kinase/Aktโ€“dependent matrix metalloproteinase-9 expression
  2461. Induction of Phosphatidylinositol 3โ€kinaseโ€mediated endocytosis by salt stress leads to intracellular production of reactive oxygen species and salt tolerance
  2462. CCL2 protects prostate cancer PC3 cells from autophagic death via Phosphatidylinositol 3โ€“kinase/AKT-dependent survivin up-regulation
  2463. Arachidonic acid activates Phosphatidylinositol 3โ€“kinase signaling and induces gene expression in prostate cancer
  2464. Phosphatidylinositol 3โ€“kinase and glycogen synthase kinase 3 regulate estrogen receptor-mediated transcription in neuronal cells
  2465. Inhibition of Phosphatidylinositol 3โ€“kinase delays tumor progression and blocks metastatic spread in a mouse model of thyroid cancer
  2466. Energy depletion inhibits Phosphatidylinositol 3โ€“kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of โ€ฆ
  2467. Highly prevalent genetic alterations in receptor tyrosine kinases and Phosphatidylinositol 3โ€“kinase/akt and mitogen-activated protein kinase pathways in anaplastic โ€ฆ
  2468. Inhibition of Phosphatidylinositol 3โ€“kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma
  2469. Myostatin induces cyclin D1 degradation to cause cell cycle arrest through a Phosphatidylinositol 3โ€“kinase/AKT/GSK-3ฮฒ pathway and is antagonized by โ€ฆ
  2470. ATP stimulates mouse embryonic stem cell proliferation via protein kinase C, Phosphatidylinositol 3โ€kinase/Akt, and mitogenโ€activated protein kinase signaling โ€ฆ
  2471. Targeting the Phosphatidylinositol 3โ€“kinase/Akt/mammalian target of rapamycin module for acute myelogenous leukemia therapy: from bench to bedside
  2472. Low-intensity pulsed ultrasound activates the Phosphatidylinositol 3 kinase/Akt pathway and stimulates the growth of chondrocytes in three-dimensional โ€ฆ
  2473. Resveratrol-caused apoptosis of human prostate carcinoma LNCaP cells is mediated via modulation of Phosphatidylinositol 3โ€ฒ-kinase/Akt pathway and Bcl-2 family โ€ฆ
  2474. โ€ฆ inhibitors used in treatment of Alzheimerโ€™s disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and Phosphatidylinositol 3โ€“kinase cascade
  2475. Dual ERK and Phosphatidylinositol 3โ€kinase pathways control airway smooth muscle proliferation: differences in asthma
  2476. A conserved role for Phosphatidylinositol 3โ€“kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy
  2477. Effects of the dual Phosphatidylinositol 3โ€“kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging
  2478. Human rhinovirus 1B exposure induces Phosphatidylinositol 3โ€“kinaseโ€“dependent airway inflammation in mice
  2479. Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when Phosphatidylinositol 3โ€“kinase signaling is suppressed
  2480. Rapid, nongenomic actions of retinoic acid on Phosphatidylinositolโ€“3โ€“kinase signaling pathway mediated by the retinoic acid receptor
  2481. Phosphatidylinositol 3โ€“kinase activation is required for stress protocol-induced modification of hippocampal synaptic plasticity
  2482. Chronic estradiol administration in vivo promotes the proinflammatory response of macrophages to TLR4 activation: involvement of the Phosphatidylinositol 3โ€“kinase โ€ฆ
  2483. Phosphatidylinositol 3โ€“kinase/AKT pathway activation in human vestibular schwannoma
  2484. Phosphatidylinositol 3โ€“kinase activity is critical for glucose metabolism and embryo survival in murine blastocysts
  2485. Extracellular acidosis induces neutrophil activation by a mechanism dependent on activation of Phosphatidylinositol 3โ€“kinase/Akt and ERK pathways
  2486. Thyroid hormone regulates developmental titin isoform transitions via the Phosphatidylinositolโ€“3โ€“kinase/AKT pathway
  2487. Blockage of epidermal growth factor receptor-Phosphatidylinositol 3โ€“kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by โ€ฆ
  2488. K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and Phosphatidylinositol 3โ€“kinase signaling
  2489. Class I and III Phosphatidylinositol 3โ€ฒ-kinase play distinct roles in TLR signaling pathway
  2490. Gene silencing reveals a specific function of hVps34 Phosphatidylinositol 3โ€“kinase in late versus early endosomes
  2491. Mammalian target of rapamycin (mTOR) inhibition activates Phosphatidylinositol 3โ€“kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute โ€ฆ
  2492. Inhibition of the Phosphatidylinositol 3โ€“kinase/mammalian target of rapamycin pathway in hematologic malignancies
  2493. Phosphatidylinositol 3โ€“kinase mediates activation of ATM by high NaCl and by ionizing radiation: Role in osmoprotective transcriptional regulation
  2494. Phosphatidylinositolโ€“3โ€“kinase signaling mediates vascular smooth muscle cell expression of periostin in vivo and in vitro
  2495. โ€ฆ stimulates cyclooxygenase-2 expression and increases bone formation through integrin, focal adhesion kinase, Phosphatidylinositol 3โ€“kinase, and Akt pathway in โ€ฆ
  2496. โ€ฆ hormone mediated changes in gene expression can be initiated by cytosolic action of the thyroid hormone receptor ฮฒ through the Phosphatidylinositol 3โ€“kinase โ€ฆ
  2497. โ€ฆ of amygdala-dependent learning by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and Phosphatidylinositolโ€“3โ€“kinase
  2498. Phosphatidylinositol 3โ€“kinase/Akt pathway is involved in transforming growth factor-ฮฒ1-induced phenotypic modulation of 10T1/2 cells to smooth muscle cells
  2499. Interleukin (IL) 1ฮฒ induction of IL-6 is mediated by a novel Phosphatidylinositol 3โ€“kinase-dependent AKT/IฮบB kinase ฮฑ pathway targeting activator protein-1
  2500. Phosphatidylinositolโ€“3โ€“kinase is involved in the antihyperglycemic effect induced by resveratrol in streptozotocin-induced diabetic rats
  2501. Erythropoietin protects against doxorubicin-induced cardiomyopathy via a Phosphatidylinositol 3โ€“kinase-dependent pathway
  2502. Hypoxia up-regulates hypoxia-inducible factor-1ฮฑ transcription by involving Phosphatidylinositol 3โ€“kinase and nuclear factor ฮบB in pulmonary artery smooth muscle โ€ฆ
  2503. Phosphatidylinositolโ€“3โ€“kinase-ฮณ is integral to homing functions of progenitor cells
  2504. Interleukin-1ฮฒ enhances GABAA receptor cell-surface expression by a Phosphatidylinositol 3โ€“kinase/Akt pathway: relevance to sepsis-associated โ€ฆ
  2505. TGF-ฮฒ1 protects against Aฮฒ-neurotoxicity via the Phosphatidylinositolโ€“3โ€“kinase pathway
  2506. Upregulation of heme oxygenase-1 by Epigallocatechin-3-gallate via the Phosphatidylinositol 3โ€“kinase/Akt and ERK pathways
  2507. โ€ฆ activation of hypoxia-inducible factor-1ฮฑ, vascular endothelial growth factor expression, and edema in the uterus are mediated by the Phosphatidylinositol 3โ€“kinase โ€ฆ
  2508. Verapamil toxicity dysregulates the Phosphatidylinositol 3โ€kinase pathway
  2509. Octreotide, a somatostatin analogue, mediates its antiproliferative action in pituitary tumor cells by altering Phosphatidylinositol 3โ€“kinase signaling and inducing Zac1 โ€ฆ
  2510. Reelin signals through Phosphatidylinositol 3โ€“kinase and Akt to control cortical development and through mTor to regulate dendritic growth
  2511. FOXO1 regulates L-Selectin and a network of human T cell homing molecules downstream of Phosphatidylinositol 3โ€“kinase
  2512. Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/Phosphatidylinositol 3โ€“kinase/Akt2 feedback signaling
  2513. โ€ฆ Protects Vascular Endothelial Cells against Apoptosis through a Gฮฑi Protein-Dependent Activation of Phosphatidylinositol 3โ€“kinase/Akt and Regulation of โ€ฆ
  2514. Phosphatidylinositol 3โ€“kinase/AKT signalling pathway components in human breast cancer: clinicopathological correlations
  2515. โ€ฆ cultured cortical neurons from oxidative stressโ€induced cell death through the activation of mitogenโ€activated protein kinase and Phosphatidylinositol 3โ€kinase
  2516. Regulation of Phosphatidylinositol 3โ€kinase (PI3K)/Akt and nuclear factorโ€kappa B signaling pathways in dystrophinโ€deficient skeletal muscle in response to โ€ฆ
  2517. Yeast ฮฒ-glucan amplifies phagocyte killing of iC3b-opsonized tumor cells via complement receptor 3-Syk-Phosphatidylinositol 3โ€“kinase pathway
  2518. Identification of survivalโ€related genes of the Phosphatidylinositol 3โ€ฒโ€kinase signaling pathway in glioblastoma multiforme
  2519. Transforming growth factor ฮฒ engages TACE and ErbB3 to activate Phosphatidylinositolโ€“3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to โ€ฆ
  2520. Involvement of Nrf2, p38, B-Raf, and nuclear factor-ฮบB, but not Phosphatidylinositol 3โ€“kinase, in induction of hemeoxygenase-1 by dietary polyphenols
  2521. Wnt5a promotes adhesion of human dermal fibroblasts by triggering a Phosphatidylinositolโ€“3 kinase/Akt signal
  2522. Class IA Phosphatidylinositol 3โ€“kinase: from their biologic implication in human cancers to drug discovery
  2523. Phosphatidylinositol 3โ€“kinase/protein kinase Akt negatively regulates plasminogen activator inhibitor type 1 expression in vascular endothelial cells
  2524. Phosphatidylinositol 3โ€“kinase-AKT-mammalian target of rapamycin pathway is essential for neuroendocrine differentiation of prostate cancer
  2525. Diosgenin inhibits melanogenesis through the activation of Phosphatidylinositolโ€“3โ€“kinase pathway (PI3K) signaling.
  2526. Phosphatidylinositol 3โ€“kinase inhibition broadly sensitizes glioblastoma cells to death receptorโ€“and drug-induced apoptosis
  2527. Phosphatidylinositol 3โ€“kinase Mediates Bronchioalveolar Stem Cell Expansion in Mouse Models of Oncogenic K-ras-Induced Lung Cancer
  2528. The endogenous cannabinoid system stimulates glucose uptake in human fat cells via Phosphatidylinositol 3โ€“kinase and calcium-dependent mechanisms
  2529. NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and Phosphatidylinositolโ€“3โ€“kinase in human natural killer cells
  2530. Inhibitory effect of capsaicin on B16-F10 melanoma cell migration via the Phosphatidylinositol 3โ€“kinase/Akt/Rac1 signal pathway
  2531. Gas6/Axl signaling activates the Phosphatidylinositol 3โ€“kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factorฮฑ-induced apoptosis
  2532. Tissue-and stimulus-dependent role of Phosphatidylinositol 3โ€“kinase isoforms for neutrophil recruitment induced by chemoattractants in vivo
  2533. Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of Phosphatidylinositolโ€“3โ€“kinase signaling and angiogenesis
  2534. Estrogen receptor protein interaction with Phosphatidylinositol 3โ€“kinase leads to activation of phosphorylated Akt and extracellular signal-regulated kinase 1/2 in the โ€ฆ
  2535. โ€ฆ non-provitamin A carotenoid, lutein, inhibits NF-ฮบB-dependent gene expression through redox-based regulation of the Phosphatidylinositol 3โ€“kinase/PTEN/Akt and NF โ€ฆ
  2536. Up-regulation of aldose reductase expression mediated by Phosphatidylinositol 3โ€“kinase/Akt and Nrf2 is involved in the protective effect of curcumin against oxidative โ€ฆ
  2537. Flow-Induced Cerebral Vasodilatation in Vivo Involves Activation of Phosphatidylinositolโ€“3 kinase, NADPH-Oxidase, and Nitric Oxide Synthase
  2538. Phosphorylation regulates tau interactions with Src homology 3 domains of Phosphatidylinositol 3โ€“kinase, phospholipase Cฮณ1, Grb2, and Src family kinases
  2539. Insulin and leptin induce Glut4 plasma membrane translocation and glucose uptake in a human neuronal cell line by a Phosphatidylinositol 3โ€“kinase-dependent โ€ฆ
  2540. Implication of the Phosphatidylinositolโ€“3 kinase/protein kinase B signaling pathway in the neuroprotective effect of estradiol in the striatum of 1-methyl-4-phenyl-1, 2, 3 โ€ฆ
  2541. Ginsenoside-Rg1 induces vascular endothelial growth factor expression through the glucocorticoid receptor-related Phosphatidylinositol 3โ€“kinase/Akt and ฮฒ โ€ฆ
  2542. Gonadotropins activate proteolysis and increase invasion through protein kinase A and Phosphatidylinositol 3โ€“kinase pathways in human epithelial ovarian cancer โ€ฆ
  2543. Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via Phosphatidylinositol 3โ€“kinase-dependent Rac1 activation
  2544. C-Peptide induces vascular smooth muscle cell proliferation: involvement of SRC-kinase, Phosphatidylinositol 3โ€“kinase, and extracellular signal-regulated kinase 1/2
  2545. Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III Phosphatidylinositol 3โ€“kinase
  2546. Respiratory syncytial virus inhibits granulocyte apoptosis through a Phosphatidylinositol 3โ€“kinase and NF-ฮบB-dependent mechanism
  2547. Epidermal growth factor stimulates Rac activation through Src and Phosphatidylinositol 3โ€“kinase to promote colonic epithelial cell migration
  2548. Elevated Phosphatidylinositol 3โ€“kinase activation and its clinicopathological significance in cervical cancer
  2549. Hypothalamic Phosphatidylinositol 3โ€“kinase pathway of leptin signaling is impaired during the development of diet-induced obesity in FVB/N mice
  2550. Phosphatidylinositol 3โ€“kinase ฮณ signaling through protein kinase Cฮถ induces NADPH oxidase-mediated oxidant generation and NF-ฮบB activation in endothelial โ€ฆ
  2551. Statin-induced Ras activation integrates the Phosphatidylinositol 3โ€“kinase signal to Akt and MAPK for bone morphogenetic protein-2 expression in osteoblast โ€ฆ
  2552. โ€ฆ of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and Phosphatidylinositol 3โ€“kinase signaling in cancer cells
  2553. 17ฮฒ-Estradiol abrogates apoptosis in murine skeletal muscle cells through estrogen receptors: role of the Phosphatidylinositol 3โ€“kinase/Akt pathway
  2554. ROS fusion tyrosine kinase activates a SH2 domainโ€“containing phosphatase-2/Phosphatidylinositol 3โ€“kinase/mammalian target of rapamycin signaling axis to form โ€ฆ
  2555. Phosphatidylinositol 3โ€“kinase ฮณ is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning
  2556. Synergistic collagenase expression and cartilage collagenolysis are Phosphatidylinositol 3โ€“kinase/Akt signaling-dependent
  2557. A ras inhibitor tilts the balance between Rac and Rho and blocks Phosphatidylinositol 3โ€“kinaseโ€“dependent glioblastoma cell migration
  2558. Phosphatidylinositolโ€“3โ€“kinaseโ€“atypical protein kinase C signaling is required for Wnt attraction and anteriorโ€“posterior axon guidance
  2559. Effects of protein kinase and Phosphatidylinositolโ€“3 kinase inhibitors on growth and ultrastructure of Trypanosoma cruzi
  2560. Semaphorin 3B inhibits the Phosphatidylinositol 3โ€“kinase/Akt pathway through neuropilin-1 in lung and breast cancer cells
  2561. Association between Phosphatidylinositol 3โ€“kinase Regulatory Subunit p85ฮฑ Met326Ile Genetic Polymorphism and Colon Cancer Risk
  2562. โ€ฆ -ฮด agonist enhances vasculogenesis by regulating endothelial progenitor cells through genomic and nongenomic activations of the Phosphatidylinositol 3โ€“kinase/Akt โ€ฆ
  2563. Regulation of the Phosphatidylinositol 3โ€“kinase-Akt and the mitogen-activated protein kinase pathways by ursolic acid in human endometrial cancer cells
  2564. Leptin induces macrophage lipid body formation by a Phosphatidylinositol 3โ€“kinase-and mammalian target of rapamycin-dependent mechanism
  2565. The Phosphatidylinositol 3โ€“kinase/Akt pathway negatively regulates Nod2-mediated NF-ฮบB pathway
  2566. Inhibition of mammalian target of rapamycin induces Phosphatidylinositol 3โ€“kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E โ€ฆ
  2567. Phosphatidylinositol 3โ€“kinase (PI3K) inhibitors as anticancer drugs
  2568. Role of MyD88 in Phosphatidylinositol 3โ€“kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells
  2569. Practicalities of drugging the Phosphatidylinositolโ€“3โ€“kinase/Akt cell survival signaling pathway
  2570. Epigallocatechinโ€3โ€gallate diminishes CCL2 expression in human osteoblastic cells via upโ€regulation of Phosphatidylinositol 3โ€kinase/Akt/Rafโ€1 interaction: a โ€ฆ
  2571. Basal B cell receptor-directed Phosphatidylinositol 3โ€“kinase signaling turns off RAGs and promotes B cell-positive selection
  2572. Requirement of Phosphatidylinositol 3โ€“kinase/Akt signaling pathway for regulation of tissue inhibitor of metalloproteinases-3 gene expression by TGF-ฮฒ in human โ€ฆ
  2573. Polycystin-1 induces resistance to apoptosis through the Phosphatidylinositol 3โ€“kinase/Akt signaling pathway
  2574. Syk associates with clathrin and mediates Phosphatidylinositol 3โ€“kinase activation during human rhinovirus internalization
  2575. Axl/Phosphatidylinositol 3โ€“kinase signaling inhibits mineral deposition by vascular smooth muscle cells
  2576. The involvement of Phosphatidylinositol 3โ€“kinase/Akt signaling in high glucose-induced downregulation of GLUT-1 expression in ARPE cells
  2577. Cartducin stimulates mesenchymal chondroprogenitor cell proliferation through both extracellular signalโ€regulated kinase and Phosphatidylinositol 3โ€kinase/Akt โ€ฆ
  2578. Disrupted RabGAP function of the p85 subunit of Phosphatidylinositol 3โ€“kinase results in cell transformation
  2579. Phosphatidylinositol 3โ€“kinase/protein kinase B pathway stabilizes DNA methyltransferase I protein and maintains DNA methylation
  2580. Phosphatidylinositol 3โ€“kinase/Akt pathway regulates hepatic stellate cell apoptosis
  2581. Src-family tyrosine kinase fyn phosphorylates Phosphatidylinositol 3โ€“kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell โ€ฆ
  2582. Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucleus via Phosphatidylinositol 3โ€“kinase-and phosphodiesterase 3-mediated โ€ฆ
  2583. Mitochondrial reactive oxygen species signal hepatocyte steatosis by regulating the Phosphatidylinositol 3โ€“kinase cell survival pathway
  2584. CpG DNA activates survival in murine macrophages through TLR9 and the Phosphatidylinositol 3โ€“kinase-Akt pathway
  2585. A Phosphatidylinositolโ€“3โ€“kinase-dependent signal transition regulates ARF1 and ARF6 during Fcฮณ receptor-mediated phagocytosis
  2586. CTLA-4 activation of Phosphatidylinositol 3โ€“kinase (PI 3-K) and protein kinase B (PKB/AKT) sustains T-cell anergy without cell death
  2587. Inhibition of Phosphatidylinositol 3โ€“kinase-mediated glucose metabolism coincides with resveratrol-induced cell cycle arrest in human diffuse large B-cell lymphomas
  2588. Selective regulation of CD8 effector T cell migration by the p110ฮณ isoform of Phosphatidylinositol 3โ€“kinase
  2589. Activation of STAT3 by Gฮฑs distinctively requires protein kinase A, JNK, and Phosphatidylinositol 3โ€“kinase
  2590. Involvement of multiple Phosphatidylinositol 3โ€“kinase-dependent pathways in the persistence of late-phase long term potentiation expression
  2591. Involvement of Phosphatidylinositol 3โ€“kinase-mediated up-regulation of IฮบBฮฑ in anti-inflammatory effect of gemfibrozil in microglia
  2592. Down-regulation of Phosphatidylinositol 3โ€ฒ-kinase/AKT/molecular target of rapamycin metabolic pathway by primary letrozole-based therapy in human breast cancer
  2593. Structure/function analysis of the Phosphatidylinositolโ€“3โ€“kinase domain of yeast tra1
  2594. Roles of Phosphatidylinositol 3โ€“kinase and NF-ฮบB in human cytomegalovirus-mediated monocyte diapedesis and adhesion: strategy for viral persistence
  2595. Emodin accelerates osteoblast differentiation through Phosphatidylinositol 3โ€“kinase activation and bone morphogenetic protein-2 gene expression
  2596. Intracellular network of Phosphatidylinositol 3โ€kinase, mammalian target of the rapamycin/70 kDa ribosomal S6 kinase 1, and mitogenโ€activated protein kinases โ€ฆ
  2597. Vascular endothelial growth factor protects spinal cord motoneurons against glutamateโ€induced excitotoxicity via Phosphatidylinositol 3โ€kinase
  2598. Phosphatidylinositol 3โ€“kinase activation is required to form the NKG2D immunological synapse
  2599. A peptide inhibitor derived from p55PIK Phosphatidylinositol 3โ€“kinase regulatory subunit: a novel cancer therapy
  2600. Phosphatidylinositol 3โ€“kinase, MEK-1 and p38 mediate leptin/interferon-gamma synergistic NOS type II induction in chondrocytes
  2601. Role of nongenomic activation of Phosphatidylinositol 3โ€“kinase/Akt and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase/extracellular โ€ฆ
  2602. Activation of Phosphatidylinositol 3โ€“kinase and protein kinase B/Akt in dorsal root ganglia and spinal cord contributes to the neuropathic pain induced by spinal nerve โ€ฆ
  2603. ILโ€21 promotes T lymphocyte survival by activating the Phosphatidylinositolโ€3 kinase signaling cascade
  2604. Phosphatidylinositol 3โ€“kinase and xanthine oxidase regulate nitric oxide and reactive oxygen species productions by apoptotic lymphocyte microparticles in โ€ฆ
  2605. โ€ฆ -2 secretion and invasion of glioma cells through Src/epidermal growth factor receptorโ€“mediated p38/Akt and Phosphatidylinositol 3โ€“kinase/Akt signaling pathways
  2606. Involvement of Bcl-2 family members, Phosphatidylinositol 3โ€˜-kinase/AKT and mitochondrial p53 in curcumin (diferulolylmethane)-induced apoptosis in prostate cancer
  2607. Mechanism of influenza A virus NS1 protein interaction with the p85ฮฒ, but not the p85ฮฑ, subunit of Phosphatidylinositol 3โ€“kinase (PI3K) and up-regulation of โ€ฆ
  2608. โ€ฆ is dependent on sphingosine kinase-mediated activation of Phosphatidylinositol phospholipase C, protein kinase C, ERK1/2, and Phosphatidylinositol 3โ€“kinase
  2609. Phosphatidylinositol 3โ€“kinase (PI3K) signaling and regulation of the antibody response
  2610. Ginsenoside Rb1 preconditioning protects against myocardial infarction after regional ischemia and reperfusion by activation of Phosphatidylinositolโ€“3โ€“kinase signal โ€ฆ
  2611. Inhibition of the Phosphatidylinositol 3โ€“kinase/Akt pathway sensitizes MDA-MB468 human breast cancer cells to cerulenin-induced apoptosis
  2612. Interferon-ฮณ induces human vascular smooth muscle cell proliferation and intimal expansion by Phosphatidylinositol 3โ€“kinaseโ€“dependent mammalian target of โ€ฆ
  2613. Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring Phosphatidylinositol 3โ€“kinase and c-Myc
  2614. Phosphatidylinositol 3โ€“kinase-dependent membrane recruitment of Rac-1 and p47phox is critical for ฮฑ-platelet-derived growth factor receptor-induced โ€ฆ
  2615. Localization of Fas/CD95 into the lipid rafts on down-modulation of the Phosphatidylinositol 3โ€“kinase signaling pathway
  2616. โ€ฆ 3-gallate suppresses heregulin-ฮฒ1-induced fatty acid synthase expression in human breast cancer cells by inhibiting Phosphatidylinositol 3โ€“kinase/Akt and mitogen โ€ฆ
  2617. Phosphatidylinositolโ€“3โ€“kinase activation blocks amyloid beta-induced neurotoxicity
  2618. In vivo Functional Analysis of the Counterbalance of Hyperactive Phosphatidylinositol 3โ€“kinase p110 Catalytic Oncoproteins by the Tumor Suppressor PTEN
  2619. Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active Phosphatidylinositol 3โ€“kinase ฮณ
  2620. Role of the Phosphatidylinositol 3โ€“kinase and mTOR pathways in the regulation of renal fibroblast function and differentiation
  2621. GM1โ€induced activation of Phosphatidylinositol 3โ€kinase: involvement of Trk receptors
  2622. Cancer cell-derived clusterin modulates the Phosphatidylinositol 3โ€ฒ-kinase-Akt pathway through attenuation of insulin-like growth factor 1 during serum deprivation
  2623. Phosphatidylinositol 3โ€“kinase signaling in mammalian preimplantation embryo development
  2624. Activation of Phosphatidylinositol 3โ€“kinase/protein kinase B pathway by a vanadyl compound mediates its neuroprotective effect in mouse brain ischemia
  2625. Role of crosstalk between Phosphatidylinositol 3โ€“kinase and extracellular signal-regulated kinase/mitogen-activated protein kinase pathways in arteryโ€“vein โ€ฆ
  2626. Isoorientin induces Nrf2 pathway-driven antioxidant response through Phosphatidylinositol 3โ€“kinase signaling
  2627. Activation of Rac by cadherin through the c-Srcโ€“Rap1โ€“Phosphatidylinositol 3โ€“kinaseโ€“Vav2 pathway
  2628. Phosphatidylinositol 3โ€“kinase is necessary for lens fiber cell differentiation and survival
  2629. Early Phosphatidylinositol 3โ€“kinase/Akt pathway activation limits poliovirus-induced JNK-mediated cell death
  2630. Phosphorylation of MNAR promotes estrogen activation of Phosphatidylinositol 3โ€“kinase
  2631. Hepatocyte growth factor induces glucose uptake in 3T3-L1 adipocytes through A Gab1/Phosphatidylinositol 3โ€“kinase/Glut4 pathway
  2632. Caspase-8 interacts with the p85 subunit of Phosphatidylinositol 3โ€“kinase to regulate cell adhesion and motility
  2633. Role of Focal adhesion kinase and Phosphatidylinositol 3โ€ฒ-kinase in integrin fibronectin receptor-mediated, matrix metalloproteinase-1โ€“dependent invasion by โ€ฆ
  2634. Dietary flavonoid (โˆ’) epicatechin stimulates Phosphatidylinositol 3โ€kinaseโ€dependent antiโ€oxidant response element activity and upโ€regulates glutathione in cortical โ€ฆ
  2635. Inhibition of the Phosphatidylinositol 3โ€“kinase/Akt pathway improves response of long-term estrogen-deprived breast cancer xenografts to antiestrogens
  2636. Phosphatidylinositol 3โ€“kinase/Akt positively regulates Fas (CD95)-mediated apoptosis in epidermal Cl41 cells
  2637. โ€ฆ -induced expression of Redd1 is regulated by activation of hypoxia-inducible factor-1ฮฑ and Sp1 through the Phosphatidylinositol 3โ€“kinase/Akt signaling pathway
  2638. Ca2+-regulated Pool of Phosphatidylinositolโ€“3-phosphate Produced by Phosphatidylinositol 3โ€“kinase C2ฮฑ on Neurosecretory Vesicles
  2639. Sevoflurane postโ€conditioning protects against myocardial reperfusion injury by activation of Phosphatidylinositolโ€3โ€kinase signal transduction
  2640. Inhibition of Phosphatidylinositolโ€“3โ€“kinase and mitogen-activated protein kinase kinase 1/2 prevents melanoma development and promotes melanoma regression in โ€ฆ
  2641. BCR-ABL regulates Phosphatidylinositol 3โ€“kinase-p110ฮณ transcription and activation and is required for proliferation and drug resistance
  2642. Estrogen facilitates both Phosphatidylinositol 3โ€“kinase/Akt and ERK1/2 mitogen-activated protein kinase membrane signaling required for long-term neuropeptide Y โ€ฆ
  2643. Oleic acid enhances vascular smooth muscle cell proliferation via Phosphatidylinositol 3โ€“kinase/Akt signaling pathway
  2644. Combined inhibition of the Phosphatidylinositol 3โ€“kinase/Akt and Ras/mitogen-activated protein kinase pathways results in synergistic effects in glioblastoma cells
  2645. Nitric oxide synthesis is required for exercise-induced increases in hippocampal BDNF and Phosphatidylinositol 3โ€ฒ kinase expression
  2646. Serotonin-induced growth of pulmonary artery smooth muscle requires activation of Phosphatidylinositol 3โ€“kinase/serine-threonine protein kinase B/mammalian target โ€ฆ
  2647. The recruitment of Phosphatidylinositol 3โ€“kinase to the E-cadherin-catenin complex at the plasma membrane is required for calcium-induced phospholipase C โ€ฆ
  2648. Transcriptome analysis of NF-ฮบB-and Phosphatidylinositol 3โ€“kinase-regulated genes in human cytomegalovirus-infected monocytes
  2649. Activation of Phosphatidylinositol 3โ€“kinase by membrane localization of p110ฮฑ predisposes mammary glands to neoplastic transformation
  2650. Class IB-Phosphatidylinositol 3โ€“kinase (PI3K) deficiency ameliorates IA-PI3K-induced systemic lupus but not T cell invasion
  2651. Parallel Phosphatidylinositol 3โ€“kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis
  2652. CEACAM1 (CD66a) promotes human monocyte survival via a Phosphatidylinositol 3โ€“kinase-and AKT-dependent pathway
  2653. Class I Phosphatidylinositol 3โ€kinase inhibitor LY294002 activates autophagy and induces apoptosis through p53 pathway in gastric cancer cell line SGC7901
  2654. NMDA neuroprotection against a Phosphatidylinositolโ€3 kinase inhibitor, LY294002 by NR2Bโ€mediated suppression of glycogen synthase kinaseโ€3ฮฒโ€induced โ€ฆ
  2655. โ€ฆ suppressed in primary human hepatocellular carcinomas and is mediated through inactivation of CCAAT/enhancer binding protein ฮฑ by Phosphatidylinositol 3โ€“kinase โ€ฆ
  2656. The p110ฮณ isoform of Phosphatidylinositol 3โ€kinase regulates migration of effector CD4 T lymphocytes into peripheral inflammatory sites
  2657. โ€ฆ of brain-derived neurotrophic factor against hypoxic injury in vitro requires activation of extracellular signal-regulated kinase and Phosphatidylinositol 3โ€“kinase
  2658. Phosphatidylinositol 3โ€“kinase facilitates bile acid-induced Ca2+ responses in pancreatic acinar cells
  2659. Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, Phosphatidylinositol 3โ€“kinase, Akt, NF-ฮบB, and p300 pathway in microglia
  2660. Coculture with endothelial cells enhances vascular smooth muscle cell adhesion and spreading via activation of ฮฒ1-integrin and Phosphatidylinositol 3โ€“kinase/Akt
  2661. Regulation of Akt/PKB by Phosphatidylinositol 3โ€kinaseโ€dependent andโ€independent pathways in Bโ€cell chronic lymphocytic leukemia cells: role of protein kinase Cฮฒ
  2662. The noncoding RNA, miRโ€126, suppresses the growth of neoplastic cells by targeting Phosphatidylinositol 3โ€kinase signaling and is frequently lost in colon cancers
  2663. Activation of Phosphatidylinositol 3โ€“kinase signaling by the nonstructural NS1 protein is not conserved among type A and B influenza viruses
  2664. The Phosphatidylinositol 3โ€“kinase/akt signaling pathway in medullary thyroid cancer
  2665. Insulin induces heme oxygenaseโ€1 through the Phosphatidylinositol 3โ€kinase/Akt pathway and the Nrf2 transcription factor in renal cells
  2666. Phosphatidylinositol 3โ€“kinase/Akt signaling mediates interleukin-32ฮฑ induction in human pancreatic periacinar myofibroblasts
  2667. โ€ฆ response to nitrosative stress induces expression of glutamate-cysteine ligase in PC12 cells via activation of Phosphatidylinositol 3โ€“kinase and Nrf2 signaling
  2668. c-Src is required for tropomyosin receptor kinase C (TrkC)-induced activation of the Phosphatidylinositol 3โ€“kinase (PI3K)-AKT pathway
  2669. Latent membrane protein 1 of EBV activates Phosphatidylinositol 3โ€“kinase to induce production of IL-10
  2670. Alterations of Phosphatidylinositol 3โ€kinase pathway components in epilepsyโ€associated glioneuronal lesions
  2671. โ€ฆ cell invasion and cord formation by promoting matrix metalloproteinase-2 expression through the Phosphatidylinositol 3โ€“kinase/Akt signaling pathway and AP โ€ฆ
  2672. Aspergillus fumigatus-induced interleukin-8 synthesis by respiratory epithelial cells is controlled by the Phosphatidylinositol 3โ€“kinase, p38 MAPK, and ERK1/2 โ€ฆ
  2673. Altered regulation of Phosphatidylinositol 3โ€“kinase signaling in cathepsin D-deficient brain
  2674. Phosphatidylinositol 3โ€ฒ-kinase is a critical mediator of interferon-ฮณ-induced increases in enteric epithelial permeability
  2675. Role of Phosphatidylinositolโ€3 kinase/Akt pathway in bladder cancer cell apoptosis induced by tumor necrosis factorโ€related apoptosisโ€inducing ligand
  2676. Follicle-stimulating hormone-induced aromatase in immature rat Sertoli cells requires an active Phosphatidylinositol 3โ€“kinase pathway and is inhibited via the mitogen โ€ฆ
  2677. Role of RacC for the regulation of WASP and Phosphatidylinositol 3โ€“kinase during chemotaxis of Dictyostelium
  2678. Phosphatidylinositol 3โ€“kinase in breast cancer: where from here?
  2679. Pyranone, thiopyranone, and pyridone inhibitors of Phosphatidylinositol 3โ€“kinase related kinases. Structureโˆ’ activity relationships for DNA-dependent protein kinase โ€ฆ
  2680. Nuclear receptor corepressor is a novel regulator of Phosphatidylinositol 3โ€“kinase signaling
  2681. Raft-dependent endocytosis of autocrine motility factor is Phosphatidylinositol 3โ€“kinase-dependent in breast carcinoma cells
  2682. Polyunsaturated fatty acids block platelet-activating factor-induced Phosphatidylinositol 3 kinase/Akt-mediated apoptosis in intestinal epithelial cells
  2683. Fatty acids differentially influence Phosphatidylinositol 3โ€“kinase signal transduction in endothelial cells: impact on adhesion and apoptosis
  2684. โ€ฆ UVB-Induced Inflammatory Cylooxygenase-2 Gene Expression and PGE2 Production through Regulation of the Nuclear Factor-ฮบB and Phosphatidylinositol 3โ€“kinase โ€ฆ
  2685. Phosphatidylinositol 3โ€“kinase/Akt signaling enhances nuclear localization and transcriptional activity of BRCA1
  2686. Formyl peptide receptor-1 activation enhances intestinal epithelial cell restitution through Phosphatidylinositol 3โ€“kinase-dependent activation of Rac1 and Cdc42
  2687. Targeted RNA interference of Phosphatidylinositol 3โ€kinase p110โ€ฮฒ induces apoptosis and proliferation arrest in endometrial carcinoma cells
  2688. Enhanced neutrophil motility by granulocyte colonyโ€stimulating factor: the role of extracellular signalโ€regulated kinase and Phosphatidylinositol 3โ€kinase
  2689. Fibroblast growth factor-2 is a downstream mediator of Phosphatidylinositol 3โ€“kinase-Akt signaling in 14, 15-epoxyeicosatrienoic acid-induced angiogenesis
  2690. Adhesion-related kinase induction of migration requires Phosphatidylinositolโ€“3โ€“kinase and ras stimulation of rac activity in immortalized gonadotropin-releasing โ€ฆ
  2691. Inhibition of the Phosphatidylinositol 3โ€ฒ-kinase Pathway Promotes Autocrine Fas-Induced Death of Phosphatase and Tensin Homologueโ€“Deficient Prostate Cancer โ€ฆ
  2692. Insulinโ€like growth factorโ€1โ€dependent maintenance of neuronal metabolism through the Phosphatidylinositol 3โ€kinaseโ€“Akt pathway is inhibited by C2โ€ceramide in โ€ฆ
  2693. Non-Opsonic Phagocytosis of Legionella pneumophila by Macrophages Is Mediated by Phosphatidylinositol 3โ€“kinase
  2694. Herpes Simplex Virus Us3 (โˆ’) Mutant as Oncolytic Strategy and Synergizes with Phosphatidylinositol 3โ€“kinase-Aktโ€“Targeting Molecular Therapeutics
  2695. Coxsackievirus B3 activates nuclear factor kappa B transcription factor via a Phosphatidylinositolโ€3 kinase/protein kinase Bโ€dependent pathway to improve host cell โ€ฆ
  2696. Actin cytoskeleton dynamics promotes leptin-induced vascular smooth muscle hypertrophy via RhoA/ROCK-and Phosphatidylinositol 3โ€“kinase/protein kinase B โ€ฆ
  2697. Iron causes interactions of TAK1, p21ras, and Phosphatidylinositol 3โ€“kinase in caveolae to activate IฮบB kinase in hepatic macrophages
  2698. Insulin-like growth factor II activates Phosphatidylinositol 3โ€“kinase-protooncogenic protein kinase 1 and mitogen-activated protein kinase cell signaling pathways, and โ€ฆ
  2699. Wild-type but not FAD mutant presenilin-1 prevents neuronal degeneration by promoting Phosphatidylinositol 3โ€“kinase neuroprotective signaling
  2700. Phosphatidylinositol 3โ€“kinase regulation of gastrin-releasing peptide-induced cell cycle progression in neuroblastoma cells
  2701. Epigallocatechin gallate stimulates glucose uptake through the Phosphatidylinositol 3โ€“kinase-mediated pathway in L6 rat skeletal muscle cells
  2702. Regulation of pancreatic duct cell differentiation by Phosphatidylinositolโ€“3 kinase
  2703. Granulocyte colony-stimulating factor mediates cardioprotection against ischemia/reperfusion injury via Phosphatidylinositolโ€“3โ€“kinase/Akt pathway in canine hearts
  2704. Reduced insulinโ€induced Phosphatidylinositolโ€3โ€kinase activation in peripheral blood mononuclear leucocytes from patients with Alzheimerโ€™s disease
  2705. Lethal congenital contractural syndrome type 2 (LCCS2) is caused by a mutation in ERBB3 (Her3), a modulator of the Phosphatidylinositolโ€“3โ€“kinase/Akt โ€ฆ
  2706. Phagocytosis by Lymnaea stagnalis haemocytes: a potential role for Phosphatidylinositol 3โ€“kinase but not protein kinase A
  2707. Lithium protection of phencyclidine-induced neurotoxicity in developing brain: The role of Phosphatidylinositolโ€“3 kinase/Akt and mitogen-activated protein kinase โ€ฆ
  2708. Glucocorticoid conditioning of myeloid progenitors enhances TLR4 signaling via negative regulation of the Phosphatidylinositol 3โ€“kinase-Akt pathway
  2709. Erythropoietin protects the human myocardium against hypoxia/reoxygenation injury via Phosphatidylinositolโ€3 kinase and ERK1/2 activation
  2710. Centaurin-ฮฑ1 is a Phosphatidylinositol 3โ€“kinase-dependent activator of ERK1/2 mitogen-activated protein kinases
  2711. Thrifty metabolism that favors fat storage after caloric restriction: a role for skeletal muscle Phosphatidylinositolโ€3โ€kinase activity and AMPโ€activated protein kinase
  2712. Transforming growth factor ฮฒ activation of c-Abl is independent of receptor internalization and regulated by Phosphatidylinositol 3โ€“kinase and PAK2 in โ€ฆ
  2713. Phosphatidylinositol 3โ€“kinase and p38 mitogen-activated protein kinase regulate induction of Mcl-1 and survival in glucocorticoid-treated human neutrophils
  2714. โ€ฆ -II is increased in systemic sclerosis-associated pulmonary fibrosis and contributes to the fibrotic process via Jun N-terminal kinase-and Phosphatidylinositolโ€“3 kinase โ€ฆ
  2715. โ€ฆ endothelial nitric-oxide synthase is diminished in mesenteric arteries from septic rabbits depending on the altered Phosphatidylinositol 3โ€“kinase/Akt pathway: reversal โ€ฆ
  2716. Phosphatidylinositol 3โ€“kinase-dependent transcriptional silencing of the translational repressor 4E-BP1
  2717. Phosphatidylinositol 3โ€“kinase/Akt activation by integrin-tumor matrix interaction suppresses Fas-mediated apoptosis in T cells
  2718. Simultaneous inhibition of the mitogenโ€activated protein kinase kinase and Phosphatidylinositol 3โ€ฒโ€kinase pathways enhances sensitivity to paclitaxel in ovarian โ€ฆ
  2719. RhoG regulates anoikis through a Phosphatidylinositol 3โ€“kinase-dependent mechanism
  2720. โ€ฆ corticotropin-releasing hormone-R1ฮฑ-mitogen-activated protein kinase (MAPK) interactions: the critical role of Phosphatidylinositol 3โ€“kinase in regulating ERK1/2 but โ€ฆ
  2721. Angiotensin II suppresses adriamycinโ€induced apoptosis through activation of Phosphatidylinositol 3โ€kinase/Akt signaling in human breast cancer cells
  2722. CD160-activating NK cell effector functions depend on the Phosphatidylinositol 3โ€“kinase recruitment
  2723. Melatonin stimulates glucose transport via insulin receptor substrateโ€1/Phosphatidylinositol 3โ€kinase pathway in C2C12 murine skeletal muscle cells
  2724. Platelet-derived growth factor BB induces nuclear export and proteasomal degradation of CREB via Phosphatidylinositol 3โ€“kinase/Akt signaling in pulmonary artery โ€ฆ
  2725. Requirement of Ca2+ influx- and Phosphatidylinositol 3โ€“kinase-mediated m-calpain activity for shear stress-induced endothelial cell polarity
  2726. Phosphatidylinositol 3โ€kinase pathway regulates sperm viability but not capacitation on boar spermatozoa
  2727. Peroxisome proliferatorโ€“activated receptor ฮณ regulates angiotensin IIโ€“stimulated Phosphatidylinositol 3โ€“kinase and mitogen-activated protein kinase in blood vessels โ€ฆ
  2728. Rhinovirus activates interleukin-8 expression via a Src/p110ฮฒ Phosphatidylinositol 3โ€“kinase/Akt pathway in human airway epithelial cells
  2729. Crystalโ€induced neutrophil activation. IX. Sykโ€dependent activation of class Ia Phosphatidylinositol 3โ€kinase
  2730. Makorin-2 is a neurogenesis inhibitor downstream of Phosphatidylinositol 3โ€“kinase/Akt (PI3K/Akt) signal
  2731. Enhanced antiโ€cancer effect of a Phosphatidylinositolโ€3 kinase inhibitor and doxorubicin on human breast epithelial cell lines with different p53 and oestrogen โ€ฆ
  2732. Decreased l-Type Ca2+ Current in Cardiac Myocytes of Type 1 Diabetic Akita Mice Due to Reduced Phosphatidylinositol 3โ€“kinase Signaling
  2733. Gastrin-releasing peptide receptors regulate proliferation of C6 glioma cells through a Phosphatidylinositol 3โ€“kinase-dependent mechanism
  2734. The anti-apoptotic effect of leukotriene B4 in neutrophils: a role for Phosphatidylinositol 3โ€“kinase, extracellular signal-regulated kinase and Mcl-1
  2735. Enhancement of cytokine-mediated NF-ฮบB activation by Phosphatidylinositol 3โ€“kinase inhibitors in monocytic cells
  2736. โ€ฆ -promoting domains of neuroglycan C, a brain-specific chondroitin sulfate proteoglycan, and involvement of Phosphatidylinositol 3โ€“kinase and protein kinase โ€ฆ
  2737. Phosphatidylinositol 3โ€“kinase signaling in proliferating cells maintains an anti-apoptotic transcriptional program mediated by inhibition of FOXO and non โ€ฆ
  2738. The proangiogenic phenotype of human tumor-derived endothelial cells depends on thrombospondin-1 downregulation via Phosphatidylinositol 3โ€“kinase/Akt pathway
  2739. Tissue kallikrein reverses insulin resistance and attenuates nephropathy in diabetic rats by activation of Phosphatidylinositol 3โ€“kinase/protein kinase B and adenosine โ€ฆ
  2740. Down-regulation of apolipoprotein M expression is mediated by Phosphatidylinositol 3โ€“kinase in HepG2 cells
  2741. Phosphatidylinositolโ€“3โ€“kinase regulates scavenger receptor class B type I subcellular localization and selective lipid uptake in hepatocytes
  2742. Expression of insulin-like growth factor binding protein-2 by MCF-7 breast cancer cells is regulated through the Phosphatidylinositol 3โ€“kinase/AKT/mammalian target of โ€ฆ
  2743. Protein chip discovery of secreted proteins regulated by the Phosphatidylinositol 3โ€“kinase pathway in ovarian cancer cell lines
  2744. 2โ€Methoxyestradiol attenuates Phosphatidylinositol 3โ€kinase/Akt pathwayโ€mediated metastasis of gastric cancer
  2745. โ€ฆ antiapoptotic signaling pathways activated by vasoactive intestinal polypeptide, epidermal growth factor, and Phosphatidylinositol 3โ€“kinase in prostate cancer โ€ฆ
  2746. A Trypanosoma cruzi Phosphatidylinositol 3โ€“kinase (TcVps34) is involved in osmoregulation and receptor-mediated endocytosis
  2747. Involvement of Phosphatidylinositolโ€“3 kinaseโ€“Akt and nuclear factor kappa-B pathways in the effect of frutalin on human lymphocyte
  2748. Identification and classification of genes regulated by Phosphatidylinositol 3โ€“kinase-and TRKB-mediated signalling pathways during neuronal differentiation in โ€ฆ
  2749. Sustained activation of Phosphatidylinositol 3โ€“kinase/Akt/nuclear factor ฮบB signaling mediates G protein-coupled ฮด-opioid receptor gene expression
  2750. Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the Phosphatidylinositol 3โ€“kinase/Akt pathway in multiple myeloma cells
  2751. Regulation of heme oxygenase-1 gene expression through the Phosphatidylinositol 3โ€“kinase/PKC-ฮถ pathway and Sp1
  2752. โ€ฆ signature of epidermal keratinocytes subjected to in vitro scratch wounding reveals selective roles for ERK1/2, p38, and Phosphatidylinositol 3โ€“kinase โ€ฆ
  2753. ADP-ribosylation factor 1 controls the activation of the Phosphatidylinositol 3โ€“kinase pathway to regulate epidermal growth factor-dependent growth and โ€ฆ
  2754. Blockade of the Phosphatidylinositolโ€“3โ€“kinaseโ€“Akt signaling pathway enhances the induction of apoptosis by microtubule-destabilizing agents in tumor cells in which โ€ฆ
  2755. Phosphatidylinositol 3โ€“kinase functions as a Ras effector in the signaling cascade that regulates dephosphorylation of the actin-remodeling protein cofilin after โ€ฆ
  2756. Neuroprotective effect of the stearic acid against oxidative stress via Phosphatidylinositol 3โ€“kinase pathway
  2757. The p85ฮฑ Subunit of Class IA Phosphatidylinositol 3โ€“kinase Regulates the Expression of Multiple Genes Involved in Osteoclast Maturation and Migration
  2758. Differential roles of Phosphatidylinositol 3โ€“kinase/akt pathway in retinal ganglion cell survival in rats with or without acute ocular hypertension
  2759. SREBP-1 regulates the expression of heme oxygenase 1 and the Phosphatidylinositolโ€“3 kinase regulatory subunit p55ฮณ
  2760. Synergistic interaction between 17โ€AAG and Phosphatidylinositol 3โ€kinase inhibition in human malignant glioma cells
  2761. Augmentation of sodium butyrate-induced apoptosis by Phosphatidylinositol 3โ€“kinase inhibition in the human cervical cancer cell-line
  2762. Phosphatidylinositol 3โ€“kinase/protein kinase Cฮถ-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor โ€ฆ
  2763. Roles of Phosphatidylinositol 3โ€“kinase-Akt and NADPH Oxidase in Adenosine 5โ€ฒ-Triphosphateโ€“Sensitive K+ Channel Function Impaired by High Glucose in the โ€ฆ
  2764. Activation of Phosphatidylinositol 3โ€“kinase signaling promotes aberrant pituitary growth in a mouse model of thyroid-stimulating hormone-secreting pituitary tumors
  2765. โ€ฆ matrix metalloproteinase 9 expression through activation of c-Fos via extracellular-regulated kinase and Phosphatidylinositol 3โ€“kinase pathways in human โ€ฆ
  2766. Involvement of Phosphatidylinositolโ€“3 kinase/AKT/PKCฮถ/ฮป pathway in the effect of palmitate on glucose-induced insulin secretion
  2767. Phosphatidylinositol 3โ€“kinase-dependent suppression of the human inducible nitric-oxide synthase promoter is mediated by FKHRL1
  2768. Phosphatidylinositol 3โ€“kinase and Akt nonautonomously promote perineurial glial growth in Drosophila peripheral nerves
  2769. Adipose tissue compensates for defect of Phosphatidylinositol 3โ€ฒ-kinase induced in liver and muscle by dietary fish oil in fed rats
  2770. Prolactin activates mammalian target-of-rapamycin through Phosphatidylinositol 3โ€“kinase and stimulates phosphorylation of p70S6K and 4E-binding protein-1 โ€ฆ
  2771. Regulation of Phosphatidylinositol 3โ€“kinase by polyisoprenyl phosphates in neutrophil-mediated tissue injury
  2772. The vitamin D receptorโ€mediated activation of Phosphatidylinositol 3โ€kinase (PI3Kฮฑ) plays a role in the 1ฮฑ,25โ€dihydroxyvitamin D3โ€stimulated increase in steroid โ€ฆ
  2773. Transforming growth factor-ฮฒ3 increases the invasiveness of endometrial carcinoma cells through Phosphatidylinositol 3โ€“kinase-dependent up-regulation of X โ€ฆ
  2774. Thyroid hormone rapidly stimulates alveolar Na, K-ATPase by activation of Phosphatidylinositol 3โ€“kinase
  2775. Dehydroepiandrosterone Stimulates Phosphorylation of FoxO1 in Vascular Endothelial Cells via Phosphatidylinositol 3โ€“kinase-and Protein kinase A โ€ฆ
  2776. Insulin activates hypoxia-inducible factor-1ฮฑ in human and rat vascular smooth muscle cells via Phosphatidylinositolโ€“3 kinase and mitogen-activated protein โ€ฆ
  2777. Up-regulation of the Phosphatidylinositol 3โ€“kinase/protein kinase B pathway in the ovary of rats by chronic treatment with hCG and insulin
  2778. Insulin-stimulated insulin receptor substrate-2โ€“associated Phosphatidylinositol 3โ€“kinase activity is enhanced in human skeletal muscle after exercise
  2779. High glucose enhances transient receptor potential channel canonical type 6โ€“dependent calcium influx in human platelets via Phosphatidylinositol 3โ€“kinase โ€ฆ
  2780. Critical Role of the Phosphatidylinositol 3โ€“kinase/Akt/Glycogen Synthase kinaseโ€“3ฮฒ Signaling Pathway in Recovery from Anthrax Lethal Toxin-induced Cell โ€ฆ
  2781. Phosphatidylinositol 3โ€“kinase activity and asymmetrical accumulation of F-actin are necessary for establishment of cell polarity in the early development of โ€ฆ
  2782. Phosphatidylinositol 3โ€“kinase-mediated regulation of IL-10 and IL-12 production in macrophages stimulated with CpG oligodeoxynucleotide
  2783. IL-7 activates the Phosphatidylinositol 3โ€“kinase/AKT pathway in normal human thymocytes but not normal human B cell precursors
  2784. Requirements of Phosphatidylinositolโ€“3 kinase and mammalian target of rapamycin for estrogen-induced proliferation in uterine leiomyoma-and myometrium-derived โ€ฆ
  2785. Rotavirus replication in intestinal cells differentially regulates integrin expression by a Phosphatidylinositol 3โ€“kinase-dependent pathway, resulting in increased cell โ€ฆ
  2786. โ€ฆ hydrogen peroxide regulates glutathione redox via nuclear factor erythroid 2-related factor 2 downstream of Phosphatidylinositol 3โ€“kinase during muscle differentiation
  2787. Dual roles of IL-15 in maintaining IL-7RฮฑlowCCR7โˆ’ memory CD8+ T cells in humans via recovering the Phosphatidylinositol 3โ€“kinase/AKT pathway
  2788. Fibulin-5 gene expression in human lung fibroblasts is regulated by TGF-ฮฒ and Phosphatidylinositol 3โ€“kinase activity
  2789. Upregulation of heme oxygenase-1 by brazilin via the Phosphatidylinositol 3โ€“kinase/Akt and ERK pathways and its protective effect against oxidative injury
  2790. CTL-associated antigen-4 ligation induces rapid T cell polarization that depends on Phosphatidylinositol 3โ€“kinase, Vav-1, Cdc42, and myosin light chain kinase
  2791. A comprehensive analysis of transcript signatures of the Phosphatidylinositolโ€3 kinase/protein kinase B signalโ€transduction pathway in prostate cancer
  2792. The hormonal response of estrogen receptor ฮฒ is decreased by the Phosphatidylinositol 3โ€“kinase/Akt pathway via a phosphorylation-dependent release of โ€ฆ
  2793. โ€ฆ primary endothelial cells are essential for Kaposiโ€™s sarcoma-associated herpesvirus/human herpesvirus 8-induced Phosphatidylinositol 3โ€“kinase and RhoA-GTPases โ€ฆ
  2794. Decoy receptor 3 expression in AsPC-1 human pancreatic adenocarcinoma cells via the Phosphatidylinositol 3โ€“kinase-, Akt-, and NF-ฮบB-dependent pathway
  2795. APOE4-VLDL Inhibits the HDL-Activated Phosphatidylinositol 3โ€“kinase/Akt Pathway via the Phosphoinositol Phosphatase SHIP2
  2796. Signaling through the Phosphatidylinositol 3โ€“kinase regulates mechanotaxis induced by local low magnetic forces in Entamoeba histolytica
  2797. Effect of estrogen and inhibition of Phosphatidylinositolโ€“3 kinase on Akt and FOXO1 in rat uterus
  2798. Leptin inhibits apoptosis in thymus through a janus kinase-2-independent, insulin receptor substrate-1/Phosphatidylinositolโ€“3 kinase-dependent pathway
  2799. Pioglitazone acutely stimulates adiponectin secretion from mouse and human adipocytes via activation of the Phosphatidylinositol 3โ€ฒ-kinase
  2800. B cell receptor signaling down-regulates forkhead box transcription factor class O 1 mRNA expression via Phosphatidylinositol 3โ€“kinase and Brutonโ€™s tyrosine kinase
  2801. Phosphatidylinositol 3โ€“kinaseโ€“dependent activation of akt, an essential signal for hyperthermia-induced heat-shock protein 72, is attenuated in streptozotocin-induced โ€ฆ
  2802. CAL-101, a potent selective inhibitor of the p110d isoform of Phosphatidylinositol 3โ€“kinase, attenuates PI3K signaling and inhibits proliferation and survival of Acute โ€ฆ
  2803. Differential regulation of the IL-17 receptor by ฮณc cytokines: inhibitory signaling by the Phosphatidylinositol 3โ€“kinase pathway
  2804. โ€ฆ by Activating Extracellular Signal-regulated kinase 1/2 and c-Jun NH2-Terminal kinase Downstream of Phosphatidylinositol 3โ€“kinase and Mammalian Target of โ€ฆ
  2805. The p110ฮฑ isoform of Phosphatidylinositol 3โ€“kinase is essential for polyomavirus middle T antigen-mediated transformation
  2806. Focal adhesion kinase mediates the interferonโ€ฮณโ€inducible GTPaseโ€induced Phosphatidylinositol 3โ€kinase/Akt survival pathway and further initiates a positive โ€ฆ
  2807. Phosphatidylinositol 3โ€“kinase/Akt signaling stimulates colonic mucosal cell survival during aging
  2808. The cytomegalovirus homolog of interleukin-10 requires Phosphatidylinositol 3โ€“kinase activity for inhibition of cytokine synthesis in monocytes
  2809. Pleckstrin-2 selectively interacts with Phosphatidylinositol 3โ€“kinase lipid products and regulates actin organization and cell spreading
  2810. โ€ฆ CB1 receptor antagonist rimonabant stimulates 2-deoxyglucose uptake in skeletal muscle cells by regulating the expression of Phosphatidylinositolโ€“3โ€“kinase
  2811. Adenosine induces hemeoxygenaseโ€1 expression in microglia through the activation of Phosphatidylinositol 3โ€kinase and nuclear factor E2โ€related factor 2
  2812. Leptin stimulates ฮฑ1 (I) collagen expression in human hepatic stellate cells via the Phosphatidylinositol 3โ€kinase/Akt signalling pathway
  2813. Cyclin D3 expression in melanoma cells is regulated by adhesion-dependent Phosphatidylinositol 3โ€“kinase signaling and contributes to G1-S progression
  2814. Bis (1-oxy-2-pyridinethiolato) oxovanadium (IV) enhances neurogenesis via Phosphatidylinositol 3โ€“kinase/Akt and extracellular signal regulated kinase activation in โ€ฆ
  2815. Activity of the p110-ฮฑ subunit of Phosphatidylinositolโ€“3โ€“kinase is required for activation of epithelial sodium transport
  2816. Nitric oxide mediates stretch-induced Ca2+ release via activation of Phosphatidylinositol 3โ€“kinase-Akt pathway in smooth muscle
  2817. FGF-2-induced wound healing in corneal endothelial cells requires Cdc42 activation and Rho inactivation through the Phosphatidylinositol 3โ€“kinase pathway
  2818. Roles of Phosphatidylinositol 3โ€“kinase and osteopontin in steatosis and aminotransferase release by hepatocytes treated with methionine-choline-deficient medium
  2819. โ€ฆ and activator of transcription 3, mitogen-activated protein kinase/extracellularly regulated kinase 1/2, and Phosphatidylinositol 3โ€“kinase/Akt signaling pathways
  2820. Activation of Phosphatidylinositolโ€“3 kinase regulates pancreatic duodenal homeobox-1 in duct cells during pancreatic regeneration
  2821. Effect of a fungal immunomodulatory protein from Ganoderma tsugae on cell cycle and interferon-gamma production through Phosphatidylinositol 3โ€“kinase signal โ€ฆ
  2822. Retinol decreases Phosphatidylinositol 3โ€kinase activity in colon cancer cells
  2823. Enhanced susceptibility to apoptosis of oral squamous cell carcinoma cells subjected to combined treatment with anticancer drugs and Phosphatidylinositol 3โ€“kinase โ€ฆ
  2824. Mitogen-activated protein kinase (MAPK) and Phosphatidylinositolโ€“3 kinase (PI3K) pathways differently regulate retinal pigment epithelial cell-mediated collagen gel โ€ฆ
  2825. Involvement of Phosphatidylinositolโ€“3โ€“kinase and ERK pathways in the production of TGF-ฮฒ1 by macrophages treated with liposomes composed of โ€ฆ
  2826. Improved poststorage cardiac function by poly (ADP-ribose) polymerase inhibition: role of Phosphatidylinositol 3โ€“kinase Akt pathway
  2827. Phosphatidylinositol 3โ€kinase/Akt plays a role in sphingosine 1โ€phosphateโ€stimulated HSP27 induction in osteoblasts
  2828. Estradiol regulates the insulin-like growth factor-I (IGF-I) signalling pathway: a crucial role of Phosphatidylinositol 3โ€“kinase (PI 3โ€“kinase) in estrogens requirement for โ€ฆ
  2829. โ€ฆ is associated with elevated peroxisome proliferator-activated receptor ฮณ: regulation by prostaglandin E2 via the Phosphatidylinositol 3โ€“kinase and Akt pathway
  2830. Modulation of caveolin-1 expression can affect signalling through the Phosphatidylinositol 3โ€“kinase/Akt pathway and cellular proliferation in response to insulin-like โ€ฆ
  2831. Effects of polycyclic aromatic hydrocarbons (PAHs) on vascular endothelial growth factor induction through Phosphatidylinositol 3โ€“kinase/AP-1-dependent โ€ฆ
  2832. Role of c-KIT expression level and Phosphatidylinositol 3โ€“kinase activation in survival and proliferative responses of early myeloid cells
  2833. Role of Phosphatidylinositol 3โ€“kinase/AKT as a survival pathway against CYP2E1-dependent toxicity
  2834. Insulin causes renal dopamine D1 receptor desensitization via GRK2-mediated receptor phosphorylation involving Phosphatidylinositol 3โ€“kinase and protein kinase C
  2835. CAL-101, a Selective Inhibitor of the p110ฮด Isoform of Phosphatidylinositol 3โ€“kinase, Effectively Induces Apoptosis in Primary Chronic Lymphocytic Leukemia โ€ฆ
  2836. Gene 33/RALT is induced by hypoxia in cardiomyocytes, where it promotes cell death by suppressing Phosphatidylinositol 3โ€“kinase and extracellular signal-regulated โ€ฆ
  2837. Tannin 1โ€ฮฑโ€Oโ€galloylpunicalagin induces the calciumโ€dependent activation of endothelial nitricโ€oxide synthase via the Phosphatidylinositol 3โ€kinase/Akt pathway in โ€ฆ
  2838. โ€ฆ hepatocyte growth factor-induced invasion by preventing the association of adapter protein Gab1 and Phosphatidylinositol 3โ€“kinase in melanoma cells
  2839. Role of Phosphatidylinositolโ€3โ€kinaseโ€ฮณ (PI3Kฮณ)โ€mediated pathway in 17ฮฒโ€estradiolโ€induced killing of L. mexicana in macrophages from C57BL/6 mice
  2840. โ€ฆ bovine preimplantation embryos with insulinโ€like growth factorโ€i prevents heat shockโ€induced apoptosis through activation of the Phosphatidylinositol 3โ€kinase/Akt โ€ฆ
  2841. Constitutive activation of Phosphatidylinositol 3โ€“kinase signaling pathway down-regulates TLR4-mediated tumor necrosis factor-ฮฑ release in alveolar โ€ฆ
  2842. LY294002 inhibits leukemia cell invasion and migration through early growth response gene 1 induction independent of Phosphatidylinositol 3โ€“kinase-Akt pathway
  2843. โ€ฆ oxidative stress causes PC-12 cell apoptosis by both endoplasmic reticulum stress and mitochondrial intrinsic pathway: inhibition of Phosphatidylinositol 3โ€“kinase โ€ฆ
  2844. Differential involvement of Phosphatidylinositol 3โ€kinaseโ€related protein kinases in hyperphosphorylation of replication protein A2 in response to replicationโ€mediated โ€ฆ
  2845. Activating transcription factor 3 and early growth response 1 are the novel targets of LY294002 in a Phosphatidylinositol 3โ€“kinaseโ€“independent pathway
  2846. โ€ฆ translocation of p67phox and p40phox that requires recruitment and activation of p38 MAPK, Rab5a, and Phosphatidylinositol 3โ€“kinase in human neutrophils
  2847. Hโ€2g, a glucose analog of blood group H antigen, mediates mononuclear cell recruitment via Src and Phosphatidylinositol 3โ€kinase pathways
  2848. Hyperinsulinaemia increases the gene expression of endothelial nitric oxide synthase and the Phosphatidylinositol 3โ€kinase/akt pathway in rat aorta
  2849. Cell detachment modulates TRAIL resistance in ovarian cancer cells by downregulating the Phosphatidylinositol 3โ€“kinase/Akt pathway
  2850. Role of Phosphatidylinositolโ€“3 kinase-ฮณ in the actions of glucagon-like peptide-2 on the murine small intestine
  2851. Angiopoietin 1 directly induces destruction of the rheumatoid joint by cooperative, but independent, signaling via ERK/MAPK and Phosphatidylinositol 3โ€kinase/Akt
  2852. Insulin and insulin-like growth factor-1 promote mast cell survival via activation of the Phosphatidylinositolโ€“3โ€“kinase pathway
  2853. โ€ฆ /3โ€ฒ, 5โ€ฒ-cyclic adenosine monophosphate (cAMP) signaling, possibly through a Janus kinase 2-Phosphatidylinositol 3โ€“kinase/Akt-phosphodiesterase 3-cAMP โ€ฆ
  2854. โ€ฆ Estrogen Receptor Modulator, Inhibits Lipopolysaccharide-induced Nitric Oxide Production by Inhibiting the Phosphatidylinositol 3โ€“kinase/Akt/Nuclear Factorkappa B โ€ฆ
  2855. โ€ฆ acid stimulation of the sodium/iodide symporter in MCF-7 breast cancer cells is meditated by the insulin growth factor-I/Phosphatidylinositol 3โ€“kinase and p38 mitogen โ€ฆ
  2856. Haloperidol induces the nuclear translocation of Phosphatidylinositol 3โ€ฒ-kinase to disrupt Akt phosphorylation in PC12 cells
  2857. Activation of MUC1 mucin expression by bile acids in human esophageal adenocarcinomatous cells and tissues is mediated by the Phosphatidylinositol 3โ€“kinase
  2858. Metformin improves atypical protein kinase C activation by insulin and Phosphatidylinositolโ€“3, 4, 5-(PO4) 3 in muscle of diabetic subjects
  2859. โ€ฆ to tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in oral squamous cell carcinoma cells treated with Phosphatidylinositol 3โ€“kinase โ€ฆ
  2860. CD86 stimulation on a B cell activates the Phosphatidylinositol 3โ€“kinase/Akt and phospholipase Cฮณ2/protein kinase Cฮฑฮฒ signaling pathways
  2861. Involvement of Phosphatidylinositol 3โ€“kinase and extracellular-regulated kinase in hepatic stellate cell antioxidant response and myofibroblastic transdifferentiation
  2862. Membrane electrical activity elicits inositol 1, 4, 5-trisphosphate-dependent slow Ca2+ signals through a Gฮฒฮณ/Phosphatidylinositol 3โ€“kinase ฮณ pathway in โ€ฆ
  2863. Nerve Growth Factor Inhibits Na+/H+ Exchange and HCO 3-Absorption through Parallel Phosphatidylinositol 3โ€“kinase-mTOR and ERK Pathways in Thick โ€ฆ
  2864. Electrical signals control wound healing through Phosphatidylinositolโ€“3-OH kinase-ฮณ and PTEN
  2865. โ€ฆ antigen 1 by LFA878 induces apoptosis in multiple myeloma cells and is associated with downregulation of the focal adhesion kinase/Phosphatidylinositol 3 kinase โ€ฆ
  2866. Phosphatidylinositol 3 kinase activation and AMPA receptor subunit trafficking underlie the potentiation of miniature EPSC amplitudes triggered by the activation of L โ€ฆ
  2867. Glucose and insulin synergistically activate Phosphatidylinositol 3โ€“kinase to trigger oscillations of Phosphatidylinositol 3, 4, 5-trisphosphate in beta-cells
  2868. โ€ฆ factor protects against rotenone-induced dopaminergic cell death through activation of extracellular signal-regulated kinases 1/2 and Phosphatidylinositolโ€“3 kinase โ€ฆ
  2869. Phosphatidylinositolโ€3โ€kinase inhibitor LY 294002 blocks Streptococcus mutansโ€induced interleukin (IL)โ€6 and ILโ€8 gene expression in odontoblastโ€like cells
  2870. Control of neurite outgrowth and growth cone motility by Phosphatidylinositolโ€3โ€kinase
  2871. Phase II enzyme induction by ฮฑ-lipoic acid through Phosphatidylinositol 3โ€“kinase-dependent C/EBPs activation
  2872. Phospholipase A2โ€“Modified Low-Density Lipoprotein Activates the Phosphatidylinositol 3โ€“kinase-Akt Pathway and Increases Cell Survival in Monocytic Cells
  2873. Activation of Phosphatidylinositol 3โ€“kinase/Akt limits FGF-2-induced VEGF release in osteoblasts
  2874. Inhibition of Phosphatidylinositol 3โ€“kinase causes cell death in rat osteoblasts through inactivation of Akt
  2875. Phosphatidylinositol 3โ€“kinase p85ฮฑ regulatory subunit gene PIK3R1 haplotype is associated with body fat and serum leptin in a female twin population
  2876. Effects of the Phosphatidylinositol 3โ€“kinase inhibitor in a mouse model of retinal neovascularization
  2877. Ras transformation of RIE-1 cells activates cap-independent translation of ornithine decarboxylase: regulation by the Raf/MEK/ERK and Phosphatidylinositol 3โ€“kinase โ€ฆ
  2878. Inhibition of Phosphatidylinositol 3โ€“kinase stimulates activity of the small-conductance K channel in the CCD
  2879. Insulin activates ATP-sensitive potassium channels via Phosphatidylinositol 3โ€“kinase in cultured vascular smooth muscle cells
  2880. Macrophage paraoxonase 2 (PON2) expression is upregulated by unesterified cholesterol through activation of the Phosphatidylinositol 3โ€“kinase (PI3K) pathway
  2881. Inhibition of transforming growth factor-ฮฒ/Smad signaling by Phosphatidylinositol 3โ€“kinase pathway
  2882. Synthesis of fluorescent derivatives of wortmannin and demethoxyviridin as probes for Phosphatidylinositol 3โ€“kinase
  2883. Phosphatidylinositol 3โ€“kinase and NF-ฮบB involved in epidermal growth factor-induced matrix metalloproteinase-9 expression
  2884. โ€ฆ derivative, inhibits cell proliferation and cell cycle progression via the cell cycle-related proteins by regulating Phosphatidylinositolโ€“3 kinase cascade in vascular โ€ฆ
  2885. Phosphatidylinositol 3โ€“kinase/Akt signaling mediates interleukin-6 protection against p53-induced apoptosis in M1 myeloid leukemic cells
  2886. โ€ฆ cannabinoid type 1 receptors in Neuro2A cells is mediated by the MEK-ERK MAPK pathway and is suppressed by the Phosphatidylinositol 3โ€“kinase pathway
  2887. Nitric oxide protects mast cells from activationโ€induced cell death: the role of the Phosphatidylinositolโ€3 kinaseโ€Aktโ€endothelial nitric oxide synthase pathway
  2888. โ€ฆ differentiation in response to calcitriol for expression CD11b and CD14 is regulated by myeloid zinc fingerโ€1 protein downstream of Phosphatidylinositol 3โ€kinase
  2889. The involvement of Phosphatidylinositol 3โ€“kinase in gonadotropin-releasing hormone-induced gonadotropin ฮฑ-and FSHฮฒ-subunit genes expression in clonal โ€ฆ
  2890. Differential regulation of interleukin-12 and tumour necrosis factor-ฮฑ by Phosphatidylinositol 3โ€“kinase and ERK 1/2 pathways during Mycobacterium tuberculosis โ€ฆ
  2891. Recruitment of the tyrosine phosphatase Src homology 2 domain tyrosine phosphatase-2 to the p85 subunit of Phosphatidylinositolโ€“3 (PI-3) kinase is required for โ€ฆ
  2892. The smaller isoforms of ankyrin 3 bind to the p85 subunit of Phosphatidylinositol 3โ€ฒ-kinase and enhance platelet-derived growth factor receptor down โ€ฆ
  2893. Phosphatidylinositolโ€“3 kinase/Akt/p70S6K/AP-1 signaling pathway mediated benzo (a) pyrene-induced cell cycle alternation via cell cycle regulatory proteins in โ€ฆ
  2894. Activation-induced deaminase-mediated class switch recombination is blocked by anti-IgM signaling in a Phosphatidylinositol 3โ€“kinase-dependent fashion
  2895. Phosphatidylinositol 3โ€kinase/Akt autoโ€regulates PDGFโ€BBโ€stimulated interleukinโ€6 synthesis in osteoblasts
  2896. Type 2 diabetes impairs insulin receptor substrate-2-mediated Phosphatidylinositol 3โ€“kinase activity in primary macrophages to induce a state of cytokine resistance to โ€ฆ
  2897. Phosphatidylinositolโ€“3โ€“kinase regulates mast cell ion channel activity
  2898. Regulation of RalA GTPase by Phosphatidylinositol 3โ€“kinase as visualized by FRET probes
  2899. Expression and clinical significance of Phosphatidylinositol 3โ€“kinase and protein kinase B in cervical carcinoma
  2900. Fibroblast growth factor-2 suppresses oridonin-induced L929 apoptosis through extracellular signal-regulated kinase-dependent and Phosphatidylinositol 3โ€“kinase โ€ฆ
  2901. Thrombin induces osteoprotegerin synthesis via Phosphatidylinositol 3โ€ฒโ€kinase/mammalian target of rapamycin pathway in human periodontal ligament cells
  2902. Phosphatidylinositol 3โ€“kinase in the G Protein-Coupled Receptorโ€“Induced Chemokinesis and Chemotaxis of MDA-MB-468 Breast Carcinoma Cells: A Comparison โ€ฆ
  2903. Induction of Monocyte Chemotactic Protein 1 in Colonic Epithelial Cells by Entamoeba histolytica Is Mediated via the Phosphatidylinositol 3โ€“kinase/p65 Pathway
  2904. The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by Phosphatidylinositol 3โ€“kinase/Akt intracellular signaling โ€ฆ
  2905. Simultaneous blockade of AP-1 and Phosphatidylinositol 3โ€“kinase pathway in non-small cell lung cancer cells
  2906. Triiodothyronine utilizes Phosphatidylinositol 3โ€“kinase pathway to activate anti-apoptotic myeloid cell leukemia-1
  2907. Distinct modes of activation of Phosphatidylinositol 3โ€“kinase in response to cyclic adenosine 3โ€ฒ, 5โ€ฒ-monophosphate or insulin-like growth factor I play different roles โ€ฆ
  2908. Proline 326 in the C terminus of murine CX3CR1 prevents G-protein and Phosphatidylinositol 3โ€“kinase-dependent stimulation of Akt and extracellular signal-regulated โ€ฆ
  2909. โ€ฆ in gastric ulcer healing: promotes actin polymerization, cell proliferation, re-epithelialization, and induces cyclooxygenase-2 in a Phosphatidylinositol 3โ€“kinase โ€ฆ
  2910. โ€ฆ prevents TGF-ฮฒ-induced damage of the plasma membrane in cerebellar granule neurons by suppressing activation of p38-MAPK via the Phosphatidylinositol 3โ€“kinase โ€ฆ
  2911. Phosphatidylinositol 3โ€“kinase-dependent insulin regulation of long-chain fatty acid (LCFA) metabolism in L6 muscle cells: involvement of atypical protein kinase โ€ฆ
  2912. Phosphatidylinositol 3โ€“kinase/Akt plays a part in tumor necrosis factor-ฮฑ-induced interleukin-6 synthesis in osteoblasts
  2913. โ€ฆ ฮฑโ€mediated human polymeric immunoglobulin receptor expression is regulated by both mitogenโ€activated protein kinase and Phosphatidylinositolโ€3โ€kinase in HTโ€29 โ€ฆ
  2914. โ€ฆ the 12-lipoxygenase gene expression and promotes cell proliferation in human keratinocytes via the extracellular regulatory kinase and Phosphatidylinositol 3โ€“kinase โ€ฆ
  2915. AMF/PGI transactivates the MMP-3 gene through the activation of Src-RhoA-Phosphatidylinositol 3โ€“kinase signaling to induce hepatoma cell migration
  2916. Phosphatidylinositol 3โ€“kinase improves the efficiency of positive selection
  2917. Sustained B7/CD28 interactions and resultant Phosphatidylinositol 3โ€kinase activity maintain G1โ†’S phase transitions at an optimal rate
  2918. Ischemia-related changes of glial-derived neurotrophic factor and Phosphatidylinositol 3โ€“kinase in the hippocampus: Their possible correlation in astrocytes
  2919. Inhibitors of Phosphatidylinositol 3โ€“kinase activity prevent cell cycle progression and induce apoptosis at the M/G1 transition in CHO cells
  2920. Phosphatidylinositol 3โ€“kinase is involved in prostaglandin E2-mediated murine duodenal bicarbonate secretion
  2921. Stimulation of interferon-ฮฒ gene expression by human cytomegalovirus via nuclear factor kappa B and Phosphatidylinositol 3โ€“kinase pathway
  2922. Insulin-like growth factor-1 delays Fas-mediated apoptosis in human neutrophils through the Phosphatidylinositolโ€“3 kinase pathway
  2923. โ€ฆ 3 modulates barrier properties of human glomerular endothelial cells through a possible signaling pathway involving Phosphatidylinositolโ€3 kinase/protein kinase B โ€ฆ
  2924. Two specific inhibitors of the Phosphatidylinositol 3โ€“kinase LY294002 and wortmannin up-regulate ฮฒ1, 4-galactosyltransferase I and thus sensitize SMMC-7721 โ€ฆ
  2925. Modulation of dendritic cell differentiation by colonyโ€stimulating factorโ€1: role of Phosphatidylinositol 3โ€ฒโ€kinase and delayed caspase activation
  2926. Protease-activated receptor-2 simultaneously directs ฮฒ-arrestin-1-dependent inhibition and Gฮฑq-dependent activation of Phosphatidylinositol 3โ€“kinase
  2927. Enhancement of susceptibility to Fas-mediated apoptosis in oral squamous cell carcinoma cells by Phosphatidylinositol 3โ€“kinase inhibitor
  2928. Peripubertal hyperinsulinemia upregulates Phosphatidylinositol 3โ€“kinase/Akt pathway in rat ovaries
  2929. Additive effects of PI3โ€“kinase and MAPK activities on NB4 cell granulocyte differentiation: potential role of Phosphatidylinositol 3โ€“kinase ฮณ
  2930. Erythropoietin enhances the therapy potency of autologous bone marrow stromal cells in a rat heart infarction model via Phosphatidylinositolโ€“3โ€“kinase/Akt pathway
  2931. The Effect of Estradiol on in Vivo Tumorigenesis Is Modulated by the Human Epidermal Growth Factor Receptor 2/Phosphatidylinositol 3โ€“kinase/Akt1 Pathway
  2932. Two populations of p27 use differential kinetics to phosphorylate Ser-10 and Thr-187 via Phosphatidylinositol 3โ€“kinase in response to fibroblast growth factor โ€ฆ
  2933. โ€ฆ morphogenetic protein-2-induced osteogenic differentiation of rat spinal ligament cells via extracellular signal-regulated kinase and Phosphatidylinositol 3โ€“kinase
  2934. Detection and significance of Phosphatidylinositol 3โ€“kinase in adipose tissue of polycystic ovary syndrome patients with insulin resistance
  2935. E-cadherin increases squamous cell carcinoma antigen expression through Phosphatidylinositolโ€“3 kinase-Akt pathway in squamous cell carcinoma cell lines
  2936. Dietary salt activates an endothelial proline-rich tyrosine kinase 2/c-Src/Phosphatidylinositol 3โ€“kinase complex to promote endothelial nitric oxide synthase โ€ฆ
  2937. Drug-resistant Phosphatidylinositol 3โ€“kinase: guidance for the preemptive strike
  2938. Sphingosine kinase, Phosphatidylinositol 3โ€“kinase, Akt, NF-ฮบB, and p300 are required for CCL5 production in Mycobacterium bovis Bacillus Calmetteโ€“Guรฉrin (BCG) โ€ฆ
  2939. Specific inhibition of basal mitogen-activated protein kinases and Phosphatidylinositol 3 kinase activities in leukemia cells: a possible therapeutic role for the โ€ฆ
  2940. โ€ฆ kinase A-independent cAMP stimulation of progesterone in a luteal cell model is tyrosine kinase dependent but Phosphatidylinositolโ€“3โ€“kinase and mitogen-activated โ€ฆ
  2941. Functional role of Phosphatidylinositol 3โ€“kinase/Akt pathway on cell growth and lytic cycle of Epsteinโ€“Barr virus in the Burkittโ€™s lymphoma cell line, P3HR-1
  2942. Defective Phosphatidylinositol 3โ€“kinase signaling in central control of cardiovascular effects in the nucleus tractus solitarii of spontaneously hypertensive rats
  2943. 1ฮฑ,25โ€Dihydroxycholecalciferol activates binding of CREB to a CRE site in the CD14 promoter and drives promoter activity in a Phosphatidylinositolโ€3 kinase โ€ฆ
  2944. LY294002 inhibits glucocorticoid-induced COX-2 gene expression in cardiomyocytes through a Phosphatidylinositol 3 kinase-independent mechanism
  2945. Schizosaccharomyces pombe Sst4p, a Conserved Vps27/Hrs Homolog, Functions Downstream of Phosphatidylinositol 3โ€“kinase Pik3p To Mediate Proper Spore โ€ฆ
  2946. Phosphatidylinositol 3โ€“kinase/nuclear factor-ฮบB signaling pathway is involved in the regulation of IGF-I on Fas-associated death domain-like interleukin-1 โ€ฆ
  2947. Glycine-extended gastrin activates two independent tyrosine-kinases in upstream of p85/p110 Phosphatidylinositol 3โ€“kinase in human colonic tumour cells
  2948. Identification and characterization of the catalytic subunit of Phosphatidylinositol 3โ€“kinase in the yellow fever mosquito Aedes aegypti
  2949. The Phosphatidylinositol 3โ€“kinase-mediated production of interferon-ฮฒ is critical for the lipopolysaccharide inhibition of osteoclastogenesis
  2950. โ€ฆ a multimeric signaling complex involving grb-2-associated binder 2 (gab2), SRC homology phosphatase-2, and Phosphatidylinositol 3โ€“kinase: evidence that negative โ€ฆ
  2951. โ€ฆ Increases the Activity of Rat Excitatory Amino Acid Transporter Type 4 Expressed in Xenopus Oocytes: Role of Protein kinase C and Phosphatidylinositol 3โ€kinase
  2952. Rotenone-induced neurotoxicity of THP-1 cells requires production of reactive oxygen species and activation of Phosphatidylinositol 3โ€“kinase
  2953. Possible involvement of Phosphatidylinositol 3โ€“kinase, but not protein kinase B or glycogen synthase kinase 3ฮฒ, in progesterone-induced oocyte maturation in the โ€ฆ
  2954. Phospholipase C, Phosphatidylinositol 3โ€“kinase, and intracellular [Ca2+] mediate the activation of chicken HD11 macrophage cells by CpG oligodeoxynucleotide
  2955. The Phosphatidylinositol 3 kinase pathway regulates tolerance to lipopolysaccharide and priming responses to Staphylococcus aureus and lipopolysaccharide
  2956. โ€ฆ prevents oxidized low-density lipoprotein-induced injury of renal tubular epithelial cells by inhibiting the Phosphatidylinositol 3โ€“kinase/Akt-signaling pathway.
  2957. โ€œPIKingโ€ the Winner for Phosphatidylinositol 3โ€“kinase Inhibitors in ErbB2-Positive Breast Cancer: Letโ€™s Not โ€œPTENedโ€ Itโ€™s Easy!
  2958. Phosphatidylinositolโ€“3-phosphate kinase pathway activation protects leukemic large granular lymphocytes from undergoing homeostatic apoptosis
  2959. The Phosphatidylinositol 3โ€“kinase inhibitor LY 294002 inhibits GlyT1-mediated glycine uptake
  2960. Platelet-derived growth factor-BB amplifies PGF2ฮฑ-stimulated VEGF synthesis in osteoblasts: Function of Phosphatidylinositol 3โ€“kinase
  2961. Expression of mitogen-actived protein kinase, Phosphatidylinositol 3โ€“kinase and hypoxia-inducible factor-1alpha in pulmonary arteries of patients with chronic โ€ฆ
  2962. Fab1 Phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors
  2963. Expression of Phosphatidylinositolโ€“3 kinase in epithelial ovarian carcinoma
  2964. Phosphatidylinositol 3โ€“kinase/mammalian target of rapamycin pathway is critical for survival and proliferation of pancreatic cancer stem-like side population cells
  2965. Effects of Huanglian Jiedu Decoction on Phosphatidylinositolโ€“3โ€“kinase expression in target tissues of type 2 diabetic rats
  2966. Stem cell factor (SCF)-kit mediated Phosphatidylinositol 3 (PI3) kinase signaling during mammalian oocyte growth and early follicular development
  2967. Febrile temperatures control antineutrophil cytoplasmic autoantibodyโ€“induced neutrophil activation via inhibition of Phosphatidylinositol 3โ€kinase/Akt
  2968. Recent patents of gene sequences relative to the Phosphatidylinositol 3โ€“kinase/Akt pathway and their relevance to drug discovery
  2969. โ€ฆ cellโ€cycle progression in Xenopus oocytes independent of direct Grb2 and Shc binding or mos synthesis, but requires Phosphatidylinositol 3โ€kinase and raf signaling
  2970. Pleiotropic Effects of Phosphatidylinositol 3โ€kinase in Monocyte Cell Regulation
  2971. Phosphatidylinositolโ€“3-OH kinase or RAS pathway mutations in human breast cancer cell lines
  2972. Phosphatidylinositolโ€“3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking
  2973. Up-regulation of gonadotropin alpha-subunit gene by Phosphatidylinositol 3โ€“kinase inhibitors in clonal gonadotroph cells.
  2974. SH3 domain of the Phosphatidylinositol 3โ€“kinase regulatory subunit is responsible for the formation of a sequestration complex with insulin receptor substrate-1
  2975. Inhibition of Phosphatidylinositol 3โ€“kinase (PI3K) signalling leads to resistance to chemotherapeutic agents in human cancer cells
  2976. Expression of Phosphatidylinositol 3โ€“kinase and effects of wortmannin on the expression of tumor necrosis factor-alpha in ulcerative colitis
  2977. Nongenomic activation of Phosphatidylinositol 3โ€“kinase by thyroid hormone
  2978. Overexpression of the p85ฮฑ regulatory subunit of Phosphatidylinositol 3โ€“kinase inhibits GM-CSF-dependent colony formation of CD34+ hematopoietic progenitor cells
  2979. Phosphatidylinositol 3โ€“kinase is a positive regulator of gibberellin signaling
  2980. Calcium-induced Human Keratinocytes (HaCaT) Differentiation Requires Protein kinase B Activation in Phosphatidylinositol 3โ€“kinase-dependent Manner
  2981. SF1126, a novel integrin-targeting Phosphatidylinositolโ€“3 kinase inhibitor, has radiosensitizing and anti-tumor effects in glioma model systems
  2982. Exogenous application of persephin influences Phosphatidylinositolโ€“3 kinase and MAPK/ERK signalling and enhances proliferation during early development in โ€ฆ
  2983. Study on crosstalk between Phosphatidylinositol 3โ€“kinase/Akt pathway and p38 mitogen-activated protein kinase pathway in cardiomyocyte with challenge of burn โ€ฆ
  2984. TIMP-3 and Phosphatidylinositol 3โ€“kinase genes were found to be related to the progression of colon cancer in a comparison of pneumoperitoneum and laparotomy in โ€ฆ
  2985. Investigating the function of class I Phosphatidylinositol 3โ€“kinase isoforms in glioma cell lines by siRNA-mediated depletion
  2986. Atg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by Phosphatidylinositol 3, 5-bisphosphate
  2987. Deregulation of the Phosphatidylinositol 3โ€“kinase pathway in the airway epithelium of smokers is associated with lung cancer
  2988. local shRNA modulation of Phosphatidylinositol 3โ€“kinase signaling pathway reduces intimal hyperplasia in vein grafts: experiment with rats
  2989. PI-103, a Dual Inhibitor of Class IA Phosphatidylinositol 3โ€“kinase and Mammalian Target of Rapamycin, Has Cytotoxic Activity in T-Cell Acute Lymphoblastic โ€ฆ
  2990. Dual regulation of glucocorticoid-induced leucine zipper (GILZ) by the glucocorticoid receptor and Phosphatidylinositol 3โ€“kinase/AKT pathways in multiple myeloma
  2991. The Involvement of Phosphatidylinositolโ€“3 kinase signaling in
  2992. Carvedilol Sensitizes Beta1- And Beta2-Adrenergic Receptors In Human Myocardium By Inhbiting A Phosphatidylinositolโ€“3 kinaseโ€“ And Phosphodiesterase 4 โ€ฆ
  2993. All-Trans Retinoic Acid Accelerates Migration of MOLT3 to SDF-1 ฮฑ/CXCL12 through the Phosphatidylinositol 3 kinase (PI3K)/Akt Pathway.
  2994. Cardioprotection induced by olprinone, a phosphodiesterase III inhibitor, involves Phosphatidylinositolโ€“3-OH kinase-Akt and a mitochondrial permeability transition โ€ฆ
  2995. Illuminating the Phosphatidylinositol 3โ€“kinase/Akt pathway
  2996. Resveratrol regulates Bcl-2 family members, Phosphatidylinositol 3โ€˜-kinase/AKT, mitochondrial p53 and apoptosis in prostate cancer cells.
  2997. Variation in the regulatory subunit p85alpha of Phosphatidylinositol 3โ€“kinase, PIK3R1, is associated with common forms of stroke
  2998. Structure/Function Analysis of the Phosphatidylinositolโ€“3โ€“kinase Domain of Yeast Tral.
  2999. Assortment of Phosphatidylinositol 3โ€“kinase complexesโ€“Atg14p directs association of complex I
  3000. Phosphatidylinositol 3โ€“kinase/Akt signaling pathway and angiogenesis
  3001. Study of nuclear targets of Phosphatidylinositolโ€“3 kinase in lymphocytes
  3002. Phosphatidylinositol 3โ€“kinase: a potential therapeutic target in oxidative stress and platelet aggregation
  3003. Phosphatidylinositol 3โ€“kinase Mediates Bronchioalveolar Stem Cell Expansion in Mouse
  3004. Understanding Phosphatidylinositol 3โ€“kinase independent survival pathways in the prostate cancer model, LNCaP
  3005. Inhibition of Phosphatidylinositol 3โ€˜โ€“kinase/akt Signalling Does Not Affect Retinal Lightโ€“Susceptibility
  3006. Protein kinase C and Phosphatidylinositol 3 kinase involved in the mechanism of myocardial remodeling in patients with congestive heart failure
  3007. The investigation of Phosphatidylinositol 3โ€“kinase (PI3K) isoforms which express by human prostate cancer cell lines, PC3 and DU145
  3008. Phosphatidylinositol 3โ€“kinase and Xanthine
  3009. The role of the Phosphatidylinositolโ€“3 kinase-AKT pathway in determining radiation sensitivity in the breast cancer cell line MDA-MB 231.
  3010. Nongenomic activation of Phosphatidylinositol 3โ€“kinase signaling by thyroid hormone receptors
  3011. Association between Phosphatidylinositol 3โ€“kinase Regulatory Subunit p85A Met326Ile Genetic Polymorphism and Colon Cancer Risk
  3012. Differential induction of adoptosis during simulated ischaemia and hypoxia in myotubes: the role of the Phosphatidylinositol 3โ€“kinase (PI3-K) signalling pathway
  3013. Angelica Polysaccharides Promotes Thrombopoiesis through the Phosphatidylinositol 3โ€“kinase/Akt Pathway.
  3014. Inhibition of Phosphatidylinositol 3โ€“kinase (PI3K) Improves Contractility in ฮฑ-Adrenergic Stimulated Myocardium
  3015. The Role of the Phosphatidylinositolโ€“3 kinase-Akt-Glycogen Synthase kinase 3P Pathway in Protection from Myocardial Ischemia/Reperfusion Injury
  3016. H11 kinase Promotes Cardiac Cell Growth and Survival Through an mTOR-Mediated Activation of the Phosphatidylinositolโ€“3โ€“kinase Pathway
  3017. Effect of Phosphatidylinositol 3โ€“kinase inhibition on estradiol-induced proliferation and hyperplasia formation in the mouse uterus
  3018. Insulin activates nuclear phospholipase C independently of Phosphatidylinositol 3โ€“kinase/Akt in HL-60 cells
  3019. Phosphatidylinositol 3โ€“kinase/AKT pathway is involved in retinoic acid-induced neuroblastoma cell differentiation
  3020. Abnormal signaling activity of Phosphatidylinositol 3โ€“kinase pathway in peripheral blood T cells from patients with systemic lupus erythematosus
  3021. Phosphatidylinositol 3โ€“kinase Regulates the Inflammatory Response of Macrophages to dsRNA and Encephalomyocarditis Virus.
  3022. Role of Phosphatidylinositol 3โ€“kinase in murine duodenal ion transport and bicarbonate secretion
  3023. Electrical signals control wound healing via Phosphatidylinositolโ€“3 kinase ฮณ and PTEN
  3024. Supplemental Data Regulation of Class Switch Recombination and Plasma Cell Differentiation by Phosphatidylinositol 3โ€“kinase Signaling
  3025. Nerve Growth Factor Inhibits Naโบ/Hโบ Exchange and {f1} Absorption through Parallel Phosphatidylinositol 3โ€“kinase-mTOR and ERK Pathways in Thick Ascending โ€ฆ
  3026. Inhibition of the Phosphatidylinositol 3โ€“kinase/AKT pathway using small molecule inhibitor (QLT0267) against ILK can be used to sensitize breast tumour cells to โ€ฆ
  3027. Phosphatidylinositol 3โ€“kinase regulates bombesin-induced angiogenesis and in vivo neuroblastoma growth
  3028. Phospholipase D and Phosphatidylinositol 3โ€kinase are Activated by Oxidative Stress in Central Nervous System.
  3029. The p85ฮฑ regulatory subunit of Phosphatidylinositol 3โ€kinase critically modulates class switch DNA recombination
  3030. Phosphatidylinositol 3โ€“kinase stimulates the proliferation of bronchioalveolar stem cells in mouse models of oncogenic K-ras-induced lung cancer
  3031. Acute simulated hypoxia and ischemia in cultured C2C12 myotubes: decreased Phosphatidylinositol 3โ€“kinase (PI3K)/Akt activity and its consequences for cell survival
  3032. Protein chip discovery of secreted proteins regulated by the Phosphatidylinositol 3โ€“kinase pathway in ovarian cancer cell lines
  3033. Regulation of plateletโ€activating factor (PAF) receptor by p85ฮฑ subunit of Phosphatidylinositol 3โ€kinase (PI3K) in enterocytes
  3034. Phosphatidylinositol 3โ€“kinase and MYCN regulation of VEGF expression in neuroblastoma cells
  3035. Role of Phosphatidylinositol 3 kinase (PI3โ€kinase) in Regulation of Apical Membrane Expression of the Type IIa Sodiumโ€Phosphate Cotransporter (Npt2a)
  3036. Model Organisms and Disease; Phosphatidylinositolโ€“3โ€“kinase/Akt and glycogen synthase kinaseโ€“3ฮฒ-mediated neuroprotective action of (-)-epigallocatechin-3-gallate โ€ฆ
  3037. โ€ฆ -dioctanoyl-PI induces cell death in the human leukemic monocyte lymphoma cell line U-937 by disruption of the Phosphatidylinositol 3โ€“kinase (PI3K)/Akt pathway โ€ฆ
  3038. Beclin-1-hVps34 Phosphatidylinositol 3โ€“kinase complexes function in autophagic and endocytic pathways
  3039. Erythropoietin-mediated protection against hypoxia/reoxygenation injury in human muscle is via Phosphatidylinositolโ€“3โ€“kinase and p42/44 kinase activation
  3040. Inhibition of mammalian target of rapamycin (mTOR) induces Phosphatidylinositol 3 kinase-dependent and Mnk-mediated eIF4E phosphorylation
  3041. Protein chip discovery of secreted proteins regulated by the Phosphatidylinositol 3โ€“kinase pathway in ovarian cancer cell lines: M. Moscova, DJ Marsh, RC Baxter โ€ฆ
  3042. Interferon-Induces Human Vascular Smooth Muscle Cell Proliferation and Intimal Expansion by Phosphatidylinositol 3โ€“kinaseโ€“Dependent Mammalian Target of โ€ฆ
  3043. 49: Phosphatidylinositol 3โ€“kinase pathway regulates hypoxia-inducible factor-1 to protect from intestinal injury during necrotizing enterocolitis
  3044. โ€ฆ polymeric immunoglobulin receptor (pIgR) expression is regulated by both mitogen activated protein kinase (MAPK) and Phosphatidylinositol 3โ€“kinase (PI3K) in HT โ€ฆ
  3045. 149 EFFECT OF GROWTH HORMONE ON EXPRESSION OF P85ฮฑ AND Phosphatidylinositol 3โ€“kinase ACTIVITY IN 3T3-L1 CELLS AND EPIDIDYMAL FAT โ€ฆ
  3046. O-009: NOD2 activates NF-kB p65 serine phosphorylation through a Phosphatidylinositol 3โ€“kinase dependant pathway
  3047. Oncogenic ras predicts lack of response to PX-866, an inhibitor of the Phosphatidylinositolโ€“3โ€“kinase pathway in tumor xenograft models.
  3048. Decreased L-Type Ca2+ Current in Cardiac Myocytes of Type 1 Diabetic Akita Mice Due to Reduced Phosphatidylinositol 3โ€“kinase Signaling.
  3049. Regulation of Fibrocyteโ€derived CXC Chemokine Receptor 4 (CXCR4) by Hypoxia and the Phosphatidylinositol 3โ€kinase (PIโ€3โ€K)/Mammalian Target of Rapamycin โ€ฆ
  3050. โ€ฆ : P-selectin Reversibly Phosphorylates Nafl/PSGL-1 Cytoplasmic Domain Complex and Dynamically Recruits Phosphatidylinositolโ€“3 kinase for Cyclic Activation and โ€ฆ
  3051. DNA-binding activity of NF-ฮบB and phosphorylation of p65 are induced by N-acetylcysteine through Phosphatidylinositol (PI) 3โ€“kinase
  3052. Role of Focal Adhesion kinase and Phosphatidylinositol 3
  3053. โ€ฆ between L-thyroxine and 3, 5, 3โ€˜-triiodo-L-thyronine and requirement for proliferation of mitogen-activated protein kinase, but not Phosphatidylinositol 3โ€“kinase.
  3054. Phosphatidylinositolโ€“3-phosphate kinase pathway activation protects
  3055. Nucleocytoplasmic shuttling of the Golgi Phosphatidylinositol 4-kinase Pik1 is regulated by 14-3โ€“3 proteins and coordinates Golgi function with cell growth
  3056. Advances in development of Phosphatidylinositol 3โ€“kinase inhibitors
  3057. Phosphatidylinositol 3โ€“kinase and antiestrogen resistance in breast cancer
  3058. Phosphatidylinositol 3โ€“kinase (PI3K) pathway activation in bladder cancer
  3059. Genetic alterations in the Phosphatidylinositolโ€“3 kinase/Akt pathway in thyroid cancer
  3060. Targeting the Phosphatidylinositol 3โ€kinase signaling pathway in breast cancer
  3061. Mutations in the Phosphatidylinositol 3โ€“kinase pathway: role in tumor progression and therapeutic implications in breast cancer
  3062. Phosphatidylinositol 3โ€“kinase: the oncoprotein
  3063. Clinical development of Phosphatidylinositol 3โ€“kinase inhibitors for cancer treatment
  3064. Take your PIK: Phosphatidylinositol 3โ€“kinase inhibitors race through the clinic and toward cancer therapy
  3065. The Phosphatidylinositol 3โ€“kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients
  3066. Phosphatidylinositol 3โ€“kinase-ฮด inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular โ€ฆ
  3067. Spectrum of Phosphatidylinositol 3โ€“kinase Pathway Gene Alterations in Bladder CancerPhosphatidylinositol 3โ€“kinase Pathway in Bladder Cancer
  3068. Direct positive regulation of PTEN by the p85 subunit of Phosphatidylinositol 3โ€“kinase
  3069. Phosphatidylinositolโ€“3โ€“kinase/Akt signaling pathway and kidney cancer, and the therapeutic potential of Phosphatidylinositolโ€“3โ€“kinase/Akt inhibitors
  3070. Phosphatidylinositol 3โ€“kinase signaling does not activate the wnt cascade
  3071. Hyperactivation of Phosphatidylinositolโ€“3 kinase promotes escape from hormone dependence in estrogen receptorโ€“positive human breast cancer
  3072. ZSTK474, a novel Phosphatidylinositol 3โ€“kinase inhibitor identified using the JFCR39 drug discovery system
  3073. In vivo antitumor activity of MEK and Phosphatidylinositol 3โ€“kinase inhibitors in basal-like breast cancer models
  3074. 3-phosphoinositideโ€“dependent kinase 1 potentiates upstream lesions on the Phosphatidylinositol 3โ€“kinase pathway in breast carcinoma
  3075. Correlating Phosphatidylinositol 3โ€“kinase Inhibitor Efficacy with Signaling Pathway Status: In silico and Biological Evaluations
  3076. New Phosphatidylinositol 3โ€“kinase inhibitors for cancer
  3077. Hot-spot mutations in p110ฮฑ of Phosphatidylinositol 3โ€“kinase (PI3K): differential interactions with the regulatory subunit p85 and with RAS
  3078. Antiangiogenic effect of ZSTK474, a novel Phosphatidylinositol 3โ€“kinase inhibitor
  3079. Phosphatidylinositol 3โ€“kinase (PI3K) signaling via glycogen synthase kinaseโ€“3 (Gsk-3) regulates DNA methylation of imprinted loci
  3080. Activation of Phosphatidylinositol 3โ€“kinase/Akt signaling pathway mediates acquired resistance to sorafenib in hepatocellular carcinoma cells
  3081. Preclinical modeling of combined Phosphatidylinositolโ€“3โ€“kinase inhibition with endocrine therapy for estrogen receptor-positive breast cancer
  3082. The role of Phosphatidylinositol 3โ€“kinase-ฮด in the immunomodulatory effects of lenalidomide in chronic lymphocytic leukemia
  3083. Liver dysfunction and Phosphatidylinositolโ€“3โ€“kinase signalling in early sepsis: experimental studies in rodent models of peritonitis
  3084. Identification of small molecule inhibitors of Phosphatidylinositol 3โ€“kinase and autophagy
  3085. Phosphatidylinositolโ€“3โ€“kinase as a therapeutic target in melanoma
  3086. Requirement of Phosphatidylinositol (3, 4, 5) Trisphosphate in Phosphatidylinositol 3โ€“kinase-Induced Oncogenic TransformationRequirement for PIP3
  3087. Thymic development beyond ฮฒ-selection requires Phosphatidylinositol 3โ€“kinase activation by CXCR4
  3088. Phosphatidylinositol 3โ€“kinase pathway activation in breast cancer brain metastases
  3089. Phosphatidylinositolโ€“3โ€“kinase and AKT1 mutations occur early in breast carcinoma
  3090. Mutations in the Phosphatidylinositolโ€“3โ€“kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for โ€ฆ
  3091. A Rap/Phosphatidylinositol 3โ€“kinase pathway controls pseudopod formation
  3092. A Phosphatidylinositol 3โ€“kinaseโ€“Pax3 axis regulates Brn-2 expression in melanoma
  3093. Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the Phosphatidylinositol 3โ€“kinase pathway
  3094. Targeting Phosphatidylinositol 3 kinase (PI3K)-Akt beyond rapalogs
  3095. Vertical targeting of the Phosphatidylinositolโ€“3 kinase pathway as a strategy for treating melanoma
  3096. BMP2 accelerates the motility and invasiveness of gastric cancer cells via activation of the Phosphatidylinositol 3โ€“kinase (PI3K)/Akt pathway
  3097. Curcumin modulates nuclear factor ฮบB (nf-ฮบB)-mediated inflammation in human tenocytes in vitro: role of the Phosphatidylinositol 3โ€“kinase/Akt pathway
  3098. The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFฮฒ-TrCP-dependent degradation in response to Phosphatidylinositol 3โ€“kinase inhibition
  3099. Noninvasive Detection of Target Modulation following Phosphatidylinositol 3โ€“kinase Inhibition Using Hyperpolarized 13C Magnetic Resonance Spectroscopy
  3100. Predictive Biomarkers of Sensitivity to the Phosphatidylinositol 3โ€ฒ kinase Inhibitor GDC-0941 in Breast Cancer Preclinical ModelsPI3K Inhibitor Biomarkers in Breast โ€ฆ
  3101. Fractalkineโ€induced activation of the Phosphatidylinositolโ€3 kinase pathway attentuates microglial activation in vivo and in vitro
  3102. The emerging role of the Phosphatidylinositol 3โ€“kinase/Akt/mammalian target of rapamycin signaling network in normal myelopoiesis and leukemogenesis
  3103. RGS16 inhibits breast cancer cell growth by mitigating Phosphatidylinositol 3โ€“kinase signaling
  3104. Molecular pharmacology of Phosphatidylinositol 3โ€“kinase inhibition in human glioma
  3105. Activation of Phosphatidylinositolโ€“3โ€ฒ-kinase/AKT signaling is essential in hepatoblastoma survival
  3106. Small-molecule inhibitors of Phosphatidylinositol 3โ€“kinase/Akt signaling inhibit Wnt/ฮฒ-catenin pathway cross-talk and suppress medulloblastoma growth
  3107. Phosphatidylinositolโ€“3โ€“kinase/akt regulates bleomycin-induced fibroblast proliferation and collagen production
  3108. Nanoparticle-mediated targeting of Phosphatidylinositolโ€“3โ€“kinase signaling inhibits angiogenesis
  3109. Phosphatidylinositol 3โ€“kinase isoforms as targets in respiratory disease
  3110. Phosphatidylinositol 3โ€“kinase-, actin-, and microtubule-dependent transport of Semliki Forest Virus replication complexes from the plasma membrane to modified โ€ฆ
  3111. Helicobacter pylori Regulates Cellular Migration and Apoptosis by Activation of Phosphatidylinositol 3โ€“kinase Signaling
  3112. Inhibition of Phosphatidylinositol 3โ€kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis
  3113. Discovery of a potent, selective, and orally available class I Phosphatidylinositol 3โ€“kinase (PI3K)/mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) โ€ฆ
  3114. The survival pathways Phosphatidylinositolโ€3 kinase (PI3โ€K)/phosphoinositideโ€dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through โ€ฆ
  3115. Phase I safety, pharmacokinetic, and pharmacodynamic study of the oral Phosphatidylinositolโ€“3โ€“kinase and mTOR inhibitor BGT226 in patients with advanced โ€ฆ
  3116. Targeting the Phosphatidylinositol 3โ€“kinase/Akt/mammalian target of rapamycin signaling network in cancer stem cells
  3117. Myricetin induces pancreatic cancer cell death via the induction of apoptosis and inhibition of the Phosphatidylinositol 3โ€“kinase (PI3K) signaling pathway
  3118. Phosphatidylinositol 3โ€“kinase inhibitor (LY294002) induces apoptosis of human nasopharyngeal carcinoma in vitro and in vivo
  3119. H1047R Phosphatidylinositol 3โ€“kinase mutant enhances HER2-mediated transformation by heregulin production and activation of HER3
  3120. Androgen receptor-dependent activation of endothelial nitric oxide synthase in vascular endothelial cells: role of Phosphatidylinositol 3โ€“kinase/akt pathway
  3121. PfPI3K, a Phosphatidylinositolโ€“3 kinase from Plasmodium falciparum, is exported to the host erythrocyte and is involved in hemoglobin trafficking
  3122. NVP-BEZ235, a novel dual Phosphatidylinositol 3โ€“kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas
  3123. The class IA Phosphatidylinositol 3โ€“kinase p110-ฮฒ subunit is a positive regulator of autophagy
  3124. Vaspin protects vascular endothelial cells against free fatty acid-induced apoptosis through a Phosphatidylinositol 3โ€“kinase/Akt pathway
  3125. Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1โ€“Phosphatidylinositolโ€“3โ€“kinase complex
  3126. Phosphatidylinositolโ€3โ€ฒโ€kinase/AKT signaling is essential in synovial sarcoma
  3127. Phosphatidylinositol 3โ€“kinase isoforms as novel drug targets
  3128. High glucose suppresses epidermal growth factor receptor/Phosphatidylinositol 3โ€“kinase/Akt signaling pathway and attenuates corneal epithelial wound healing
  3129. Macrophage differentiation and polarization via Phosphatidylinositol 3โ€“kinase/Aktโ€“ERK signaling pathway conferred by serum amyloid P component
  3130. Inhibition profiles of Phosphatidylinositol 3โ€“kinase inhibitors against PI3K superfamily and human cancer cell line panel JFCR39
  3131. Class IA Phosphatidylinositol 3โ€“kinase in pancreatic ฮฒ cells controls insulin secretion by multiple mechanisms
  3132. O2 Regulates Skeletal Muscle Progenitor Differentiation through Phosphatidylinositol 3โ€“kinase/AKT Signaling
  3133. A Phosphatidylinositol 3โ€“kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic
  3134. A gene signature-based approach identifies thioridazine as an inhibitor of Phosphatidylinositolโ€“3โ€ฒ-kinase (PI3K)/AKT pathway in ovarian cancer cells
  3135. โ€ฆ lyase knockdown and statin treatment leads to dual blockade of mitogenโ€activated protein kinase (MAPK) and Phosphatidylinositolโ€3โ€kinase (PI3K)/AKT pathways
  3136. Phosphatidylinositol 3 kinase modulation of trophoblast cell differentiation
  3137. Antimyeloma activity of the orally bioavailable dual Phosphatidylinositol 3โ€“kinase/mammalian target of rapamycin inhibitor NVP-BEZ235
  3138. Role and regulation of Phosphatidylinositol 3โ€“kinase ฮฒ in platelet integrin ฮฑ2ฮฒ1 signaling
  3139. Phosphatidylinositolโ€“3โ€“kinase gamma plays a central role in bloodโ€“brain barrier dysfunction in acute experimental stroke
  3140. The Phosphatidylinositol 3โ€“kinase/akt cassette regulates purine nucleotide synthesis
  3141. โ€ฆ object memory consolidation in middle-aged female mice requires dorsal hippocampal extracellular signal-regulated kinase and Phosphatidylinositol 3โ€“kinase โ€ฆ
  3142. Intracellular leptin-signaling pathways in hypothalamic neurons: the emerging role of Phosphatidylinositolโ€“3 kinase-phosphodiesterase-3B-cAMP pathway
  3143. Resveratrol inhibits LPS-induced MAPKs activation via activation of the Phosphatidylinositol 3โ€“kinase pathway in murine RAW 264.7 macrophage cells
  3144. TIPE2 controls innate immunity to RNA by targeting the Phosphatidylinositol 3โ€“kinaseโ€“Rac pathway
  3145. Two hits are better than one: targeting both Phosphatidylinositol 3โ€“kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia โ€ฆ
  3146. IL-10 inhibits the starvation induced autophagy in macrophages via class I Phosphatidylinositol 3โ€“kinase (PI3K) pathway
  3147. Effect of ZSTK474, a novel Phosphatidylinositol 3โ€“kinase inhibitor, on DNA-dependent protein kinase
  3148. Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of Phosphatidylinositol 3โ€“kinase (PI3K)
  3149. Inflammation and apoptosis in aortic tissues of aged type II diabetes: amelioration with ฮฑ-lipoic acid through Phosphatidylinositol 3โ€“kinase/Akt-dependent mechanism
  3150. Synthesis and biological evaluation of novel analogues of the pan class I Phosphatidylinositol 3โ€“kinase (PI3K) inhibitor 2-(difluoromethyl)-1-[4, 6-di (4-morpholinyl)-1 โ€ฆ
  3151. CAL-101: a Phosphatidylinositolโ€“3โ€“kinase p110-delta inhibitor for the treatment of lymphoid malignancies
  3152. Astragaloside IV stimulates angiogenesis and increases hypoxia-inducible factor-1ฮฑ accumulation via Phosphatidylinositol 3โ€“kinase/Akt pathway
  3153. Phosphatidylinositol 3โ€“kinase signaling in thymocytes: the need for stringent control
  3154. Role of Phosphatidylinositolโ€“3โ€“kinase pathway in head and neck squamous cell carcinoma
  3155. Knockdown of Ron kinase inhibits mutant Phosphatidylinositol 3โ€“kinase and reduces metastasis in human colon carcinoma
  3156. NF-ฮบB and Phosphatidylinositol 3โ€“kinase activity mediates the HCMV-induced atypical M1/M2 polarization of monocytes
  3157. Genetic alterations in the RAS/RAF/mitogenโ€activated protein kinase and Phosphatidylinositol 3โ€kinase/Akt signaling pathways in the follicular variant of papillary โ€ฆ
  3158. A Phosphatidylinositol 3โ€“kinase/protein kinase B-independent activation of mammalian target of rapamycin signaling is sufficient to induce skeletal muscle hypertrophy
  3159. โ€ฆ insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of Phosphatidylinositol 3โ€“kinase-Akt and MEK-ERK โ€ฆ
  3160. Phosphatidylinositol 3โ€ฒ-kinase Catalytic Subunit ฮฑ Gene Amplification Contributes to the Pathogenesis of Mantle Cell LymphomaPIK3CA Gene Amplification in MCL
  3161. Pooled analysis of Phosphatidylinositol 3โ€“kinase pathway variants and risk of prostate cancer
  3162. CAL-101, a p110ฮด selective Phosphatidylinositolโ€“3โ€“kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability
  3163. Inhibitors of Phosphatidylinositolโ€“3โ€“kinase in cancer therapy
  3164. IKBKE protein activates Akt independent of Phosphatidylinositol 3โ€“kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant โ€ฆ
  3165. Foot-and-mouth disease virus induces autophagosomes during cell entry via a class III Phosphatidylinositol 3โ€“kinase-independent pathway
  3166. Mitogenic and anti-apoptotic effects of insulin in endometrial cancer are Phosphatidylinositol 3โ€“kinase/Akt dependent
  3167. Synthesis of Phosphatidylinositol 3โ€“kinase (PI3K) inhibitory analogues of the sponge meroterpenoid liphagal
  3168. mRNA degradation plays a significant role in the program of gene expression regulated by Phosphatidylinositol 3โ€“kinase signaling
  3169. Synergy between Phosphatidylinositol 3โ€“kinase/Akt pathway and Bcl-xL in the control of apoptosis in adenocarcinoma cells of the lung
  3170. Changes related to Phosphatidylinositol 3โ€“kinase/Akt signaling in leiomyomas: possible involvement of glycogen synthase kinase 3ฮฑ and cyclin D2 in the โ€ฆ
  3171. Synthesis and characterization of a novel prostate cancer-targeted Phosphatidylinositolโ€“3โ€“kinase inhibitor prodrug
  3172. Berberine activates Nrf2 nuclear translocation and protects against oxidative damage via a Phosphatidylinositol 3โ€“kinase/Akt-dependent mechanism in NSC34 motor โ€ฆ
  3173. Spectrum of KIT/PDGFRA/BRAF mutations and Phosphatidylinositolโ€“3โ€“kinase pathway gene alterations in gastrointestinal stromal tumors (GIST)
  3174. โ€ฆ -generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1ฮฑ gene transcription via Phosphatidylinositol 3โ€“kinase-Akt/protein kinase C โ€ฆ
  3175. Nongenomic activation of Phosphatidylinositol 3โ€“kinase signaling by thyroid hormone receptors
  3176. Dual inhibition of Phosphatidylinositol 3โ€kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid โ€ฆ
  3177. Pharmacokinetic-pharmacodynamic modeling of tumor growth inhibition and biomarker modulation by the novel Phosphatidylinositol 3โ€“kinase inhibitor GDC-0941
  3178. Exercise training stimulates ischemia-induced neovascularization via Phosphatidylinositol 3โ€“kinase/Akt-dependent hypoxia-induced factor-1ฮฑ reactivation in mice of โ€ฆ
  3179. Tanshinone IIA pretreatment protects myocardium against ischaemia/reperfusion injury through the Phosphatidylinositol 3โ€kinase/Aktโ€dependent pathway in diabetic โ€ฆ
  3180. Relaxin improves TNF-ฮฑ-induced endothelial dysfunction: the role of glucocorticoid receptor and Phosphatidylinositol 3โ€“kinase signalling
  3181. Multi-level targeting of the Phosphatidylinositolโ€“3โ€“kinase pathway in non-small cell lung cancer cells
  3182. Participation of the Phosphatidylinositol 3โ€“kinase/Akt pathway in Junin virus replication in vitro
  3183. โ€ฆ ion irradiation suppresses metastatic potential of human non-small cell lung cancer A549 cells through the Phosphatidylinositolโ€“3โ€“kinase/Akt signaling pathway
  3184. โ€ฆ Network Disruption by a Single Molecule Inhibitor Targeting Both Histone Deacetylase Activity and Phosphatidylinositol 3โ€“kinase SignalingTargeting HDAC and PI3K โ€ฆ
  3185. Resveratrol modulates interleukin-1ฮฒ-induced Phosphatidylinositol 3โ€“kinase and nuclear factor ฮบB signaling pathways in human tenocytes
  3186. Activity of the Novel Dual Phosphatidylinositol 3โ€“kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235 against T-Cell Acute Lymphoblastic LeukemiaNVP โ€ฆ
  3187. The p110ฮด isoform of Phosphatidylinositol 3โ€“kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells
  3188. Hydrogen sulfide and L-cysteine increase Phosphatidylinositol 3, 4, 5-trisphosphate (PIP3) and glucose utilization by inhibiting phosphatase and tensin โ€ฆ
  3189. Inhibition of autophagy as a strategy to augment radiosensitization by the dual Phosphatidylinositol 3โ€“kinase/mammalian target of rapamycin inhibitor NVP-BEZ235
  3190. โ€ฆ G1/S cell cycle progression through bidirectional regulation of cyclins and cyclin-dependent kinase inhibitors via the Phosphatidylinositol 3โ€“kinase/Akt pathway in โ€ฆ
  3191. Isoflurane posttreatment reduces neonatal hypoxicโ€“ischemic brain injury in rats by the sphingosine-1-phosphate/Phosphatidylinositolโ€“3โ€“kinase/Akt pathway
  3192. Cell surface biliverdin reductase mediates biliverdin-induced anti-inflammatory effects via Phosphatidylinositol 3โ€“kinase and Akt
  3193. Novel function of CRTH2 in preventing apoptosis of human Th2 cells through activation of the Phosphatidylinositol 3โ€“kinase pathway
  3194. Alterations in the human epidermal growth factor receptor 2-Phosphatidylinositol 3โ€“kinase-v-Akt pathway in gastric cancer
  3195. A role for a CXCR2/Phosphatidylinositol 3โ€“kinase ฮณ signaling axis in acute and chronic vascular permeability
  3196. Differential 14-3โ€“3 affinity capture reveals new downstream targets of Phosphatidylinositol 3โ€“kinase signaling
  3197. The Class II Phosphatidylinositol 3 kinase C2ฮฒ Is Required for the Activation of the K+ Channel KCa3.1 and CD4 T-Cells
  3198. โ€ฆ induces antioxidant/detoxificant enzymes and Nrf2 translocation via extracellular regulated kinases and Phosphatidylinositolโ€3โ€kinase/protein kinase B pathways in โ€ฆ
  3199. Cdc42 and the Phosphatidylinositol 3โ€“kinase-Akt pathway are essential for PspC-mediated internalization of pneumococci by respiratory epithelial cells
  3200. LRP1 regulates architecture of the vascular wall by controlling PDGFRฮฒ-dependent Phosphatidylinositol 3โ€“kinase activation
  3201. Dual inhibition of class IA Phosphatidylinositol 3โ€“kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia
  3202. Phosphatidylinositol 3โ€“kinase: a key regulator in adherens junction formation and function
  3203. Human neuronal cells possess functional cytoplasmic and TLR-mediated innate immune pathways influenced by Phosphatidylinositolโ€“3 kinase signaling
  3204. Blockade of Phosphatidylinositol 3โ€“kinase (PI3K) ฮด or PI3Kฮณ reduces IL-17 and ameliorates imiquimod-induced psoriasis-like dermatitis
  3205. Phosphatidylinositol 3โ€“kinase plays a vital role in regulation of rice seed vigor via altering NADPH oxidase activity
  3206. Forced, moderate-intensity treadmill exercise suppresses apoptosis by increasing the level of NGF and stimulating Phosphatidylinositol 3โ€“kinase signaling in the โ€ฆ
  3207. โ€ฆ to the acquired apoptotic resistance of nonadherent ovarian cancer cells through a cross talk mediated by Phosphatidylinositol 3โ€“kinase and extracellular signal โ€ฆ
  3208. Ferulic acid protects human umbilical vein endothelial cells from radiation induced oxidative stress by Phosphatidylinositol 3โ€“kinase and extracellular signal-regulated โ€ฆ
  3209. Infection with Anaplasma phagocytophilum activates the Phosphatidylinositol 3โ€“kinase/Akt and NF-ฮบB survival pathways in neutrophil granulocytes
  3210. Activation of Phosphatidylinositol 3โ€“kinase is required for tumor necrosis factor-ฮฑ-induced upregulation of matrix metalloproteinase-9: Its direct inhibition by quercetin
  3211. Bis (morpholino-1, 3, 5-triazine) derivatives: potent adenosine 5โ€ฒ-triphosphate competitive Phosphatidylinositolโ€“3โ€“kinase/mammalian target of rapamycin inhibitors โ€ฆ
  3212. Protein kinase C-ฮด and Phosphatidylinositol 3โ€“kinase/Akt activate mammalian target of rapamycin to modulate NF-ฮบB activation and intercellular adhesion โ€ฆ
  3213. Phosphatidylinositolโ€3โ€kinase (PI3K) is activated by influenza virus vRNA via the pathogen pattern receptor Rigโ€I to promote efficient type I interferon production
  3214. E6 variants of human papillomavirus 18 differentially modulate the protein kinase B/Phosphatidylinositol 3โ€“kinase (akt/PI3K) signaling pathway
  3215. Role for the Phosphatidylinositol 3โ€“kinase-Akt-TOR pathway during sindbis virus replication in arthropods
  3216. Plant Phosphatidylinositol 3โ€“kinase
  3217. โ€ฆ (Aฮฒ) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-ฮฑ (sAPPฮฑ) by modulating Phosphatidylinositol 3โ€“kinase (PI3K)/Akt-GSK โ€ฆ
  3218. Phosphatidylinositol 3 kinaseโ€“Akt signaling serves as a circadian output in the retina
  3219. NVP-BEZ235 and NVP-BGT226, dual Phosphatidylinositol 3โ€“kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell โ€ฆ
  3220. Perfluorooctane sulfonate triggers tight junction โ€œopeningโ€ in brain endothelial cells via Phosphatidylinositol 3โ€“kinase
  3221. Treadmill exercise suppresses muscle cell apoptosis by increasing nerve growth factor levels and stimulating p-Phosphatidylinositol 3โ€“kinase activation in the soleus โ€ฆ
  3222. โ€ฆ factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the Phosphatidylinositol 3โ€“kinase/Akt โ€ฆ
  3223. Loss of function of the influenza A virus NS1 protein promotes apoptosis but this is not due to a failure to activate Phosphatidylinositol 3โ€“kinase (PI3K)
  3224. โ€ฆ effect of guanosine against glutamateโ€induced cell death in rat hippocampal slices is mediated by the Phosphatidylinositolโ€3 kinase/Akt/glycogen synthase kinase 3ฮฒ โ€ฆ
  3225. Infectious bursal disease virus activates the Phosphatidylinositol 3โ€“kinase (PI3K)/Akt signaling pathway by interaction of VP5 protein with the p85ฮฑ subunit of โ€ฆ
  3226. Role of the Phosphatidylinositolโ€“3โ€“kinase and extracellular regulated kinase pathways in the induction of hypoxia-inducible factor (HIF)-1 activity and the HIF-1 target โ€ฆ
  3227. Trpc1 ion channel modulates Phosphatidylinositol 3โ€“kinase/Akt pathway during myoblast differentiation and muscle regeneration
  3228. The Phosphatidylinositol 3โ€“kinase/mTor pathway as a therapeutic target for brain aging and neurodegeneration
  3229. Ubiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III Phosphatidylinositol 3โ€“kinase activity and tumor suppression
  3230. The roles and mechanisms of PAR4 and P2Y12/Phosphatidylinositol 3โ€kinase pathway in maintaining thrombinโ€induced platelet aggregation
  3231. Approaches and limitations of Phosphatidylinositolโ€“3โ€“kinase pathway activation status as a predictive biomarker in the clinical development of targeted therapy
  3232. Inhibitory activity of flavonoids against class I Phosphatidylinositol 3โ€“kinase isoforms
  3233. cAMP activates TRPC6 channels via the Phosphatidylinositol 3โ€“kinase (PI3K)-protein kinase B (PKB)-mitogen-activated protein kinase kinase (MEK)-ERK1/2 โ€ฆ
  3234. Alterations in Phosphatidylinositol 3โ€“kinase activity and PTEN phosphatase in the prefrontal cortex of depressed suicide victims
  3235. Propranolol improves impaired hepatic Phosphatidylinositol 3โ€“kinase/akt signaling after burn injury
  3236. MAPK, Phosphatidylinositol 3โ€“kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic โ€ฆ
  3237. The emerging role of the Phosphatidylinositol 3โ€“kinase/Akt/mammalian target of rapamycin signaling network in cancer stem cell biology
  3238. Vascular endothelial growth factor receptor-3 directly interacts with Phosphatidylinositol 3โ€“kinase to regulate lymphangiogenesis
  3239. Effect of Phosphatidylinositolโ€“3 kinase inhibition on ovotoxicity caused by 4-vinylcyclohexene diepoxide and 7, 12-dimethylbenz [a] anthracene in neonatal rat ovaries
  3240. Phosphatidylinositol 3โ€“kinase activation attenuates the TLR2-mediated macrophage proinflammatory cytokine response to Francisella tularensis live vaccine strain
  3241. Requirement of the Phosphatidylinositol 3โ€“kinase/Akt signaling pathway for the effect of nicotine on interleukin-1beta-induced chondrocyte apoptosis in a rat model of โ€ฆ
  3242. Class IA Phosphatidylinositol 3โ€“kinase signaling in non-small cell lung cancer
  3243. Non-Smad transforming growth factor-ฮฒ signaling regulated by focal adhesion kinase binding the p85 subunit of Phosphatidylinositol 3โ€“kinase
  3244. Phosphatidylinositol 3โ€“kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice
  3245. Phosphatidylinositol 3โ€“kinase/AKT/mammalian target of rapamycin pathway inhibition: a breakthrough in the management of luminal (ER+/HER2โˆ’) breast cancers?
  3246. Prostaglandin E2 induces interleukin-6 expression in human chondrocytes via cAMP/protein kinase A- and Phosphatidylinositol 3โ€“kinase-dependent NF-ฮบB activation
  3247. Characterization and targeting of Phosphatidylinositolโ€“3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in renal cell cancer
  3248. Activation of the Phosphatidylinositol 3โ€“kinase/Akt signaling pathway during porcine circovirus type 2 infection facilitates cell survival and viral replication
  3249. โ€ฆ Spinal Cord Ischemiaโ€“Reperfusion Injury Induced by Different Ischemic Postconditioning Methods: Roles of Phosphatidylinositol 3โ€“kinaseโ€“Akt and Extracellular โ€ฆ
  3250. โ€ฆ receptor ฮฑ-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to ambient IGF, leading to Phosphatidylinositol 3โ€“kinase/AKT-dependent Wnt โ€ฆ
  3251. Phosphatidylinositol 3โ€“kinase mediates pain behaviors induced by activation of peripheral ephrinBs/EphBs signaling in mice
  3252. Strain-induced proliferation requires the Phosphatidylinositol 3โ€“kinase/AKT/glycogen synthase kinase pathway
  3253. Development and evaluation of PIK75 nanosuspension, a Phosphatidylinositolโ€“3โ€“kinase inhibitor
  3254. L-Thyroxine vs. 3, 5, 3โ€ฒ-triiodo-L-thyronine and cell proliferation: activation of mitogen-activated protein kinase and Phosphatidylinositol 3โ€“kinase
  3255. Adaptor protein APPL1 couples synaptic NMDA receptor with neuronal prosurvival Phosphatidylinositol 3โ€“kinase/Akt pathway
  3256. Gender-related difference of sevoflurane postconditioning in isolated rat hearts: focus on Phosphatidylinositolโ€“3โ€“kinase/Akt signaling
  3257. Frat is a Phosphatidylinositol 3โ€“kinase/Akt-regulated determinant of glycogen synthase kinase 3ฮฒ subcellular localization in pluripotent cells
  3258. Phosphatidylinositol 3โ€kinaseโ€ฮด upโ€regulates Lโ€type Ca2+ currents and increases vascular contractility in a mouse model of type 1 diabetes
  3259. PKI-179: an orally efficacious dual Phosphatidylinositolโ€“3โ€“kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor
  3260. Insulin stabilizes microvascular endothelial barrier function via Phosphatidylinositol 3โ€“kinase/Akt-mediated Rac1 activation
  3261. Toll-Like Receptor 2- and MyD88-Dependent Phosphatidylinositol 3โ€“kinase and Rac1 Activation Facilitates the Phagocytosis of Listeria monocytogenes by Murine โ€ฆ
  3262. The Phosphatidylinositol 3โ€“kinase-AKT-mammalian target of rapamycin signaling network and the control of normal myelopoiesis
  3263. Clinical development of Phosphatidylinositolโ€“3 kinase pathway inhibitors
  3264. ฮฑ7 Nicotinic receptor activation reduces ฮฒโ€amyloidโ€induced apoptosis by inhibiting caspaseโ€independent death through Phosphatidylinositol 3โ€kinase signaling
  3265. โ€ฆ patterns in mismatch repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the Phosphatidylinositol 3โ€“kinase-AKT-mammalian target โ€ฆ
  3266. Mesenchymal stem cells inhibition of chronic ethanol-induced oxidative damage via upregulation of Phosphatidylinositolโ€“3โ€“kinase/Akt and modulation of extracellular โ€ฆ
  3267. Phosphatidylinositol 3โ€ฒ-kinase activity is critical for initiating the oxidative burst and bacterial destruction during CEACAM3-mediated phagocytosis
  3268. Phosphatidylinositol 3โ€“kinase facilitates microtubule-dependent membrane transport for neuronal growth cone guidance
  3269. Phosphatidylinositol 3โ€“kinase-Akt signaling in pulmonary carcinoid cells
  3270. Phosphatidylinositolโ€“3โ€“kinase pathway mutations are common in breast columnar cell lesions
  3271. Activation of Phosphatidylinositol 3โ€“kinase/Akt-mammalian target of Rapamycin signaling pathway in the hippocampus is essential for the acquisition of morphine โ€ฆ
  3272. โ€ฆ cells is mediated by ฮฑvฮฒ3 and ฮฒ1 integrins through synergistic interactions of focal adhesion kinase and Shc with Phosphatidylinositol 3โ€“kinase and the Akt โ€ฆ
  3273. Collagen VI protects against neuronal apoptosis elicited by ultraviolet irradiation via an Akt/Phosphatidylinositol 3โ€“kinase signaling pathway
  3274. ZSTK474, a specific Phosphatidylinositol 3โ€“kinase inhibitor, induces G1 arrest of the cell cycle in vivo
  3275. A new dimension to Ras function: A novel role for nucleotide-free Ras in class II Phosphatidylinositol 3โ€“kinase beta (PI3KC2ฮฒ) regulation
  3276. Brassinin induces G1 phase arrest through increase of p21 and p27 by inhibition of the Phosphatidylinositol 3โ€“kinase signaling pathway in human colon cancer cells
  3277. Hydrogen peroxide activates focal adhesion kinase and c-Src by a Phosphatidylinositol 3 kinase-dependent mechanism and promotes cell migration in Caco-2 cell โ€ฆ
  3278. Phosphatidylinositol 3โ€“kinase, a novel target molecule for the inhibitory effects of kaempferol on neoplastic cell transformation
  3279. โ€ฆ receptor-independent action involving the consecutive activation of Gฮฑ13, c-Src, the insulin-like growth factor-I receptor, and Phosphatidylinositol 3โ€“kinase/Akt
  3280. Hepatitis B x-interacting protein induces HepG2 cell proliferation through activation of the Phosphatidylinositol 3โ€“kinase/Akt pathway
  3281. Phosphatidylinositolโ€“3โ€“kinase p110ฮณ contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells
  3282. Phosphatidylinositol 3โ€“kinase/Akt signaling pathway mediates acupuncture-induced dopaminergic neuron protection and motor function improvement in a mouse โ€ฆ
  3283. Therapeutic targeting of the Phosphatidylinositol 3โ€“kinase signaling pathway: novel targeted therapies and advances in the treatment of colorectal cancer
  3284. t-DARPP regulates Phosphatidylinositolโ€“3โ€“kinase-dependent cell growth in breast cancer
  3285. Inhibition of Phosphatidylinositol 3โ€“kinase promotes tumor cell resistance to chemotherapeutic agents via a mechanism involving delay in cell cycle progression
  3286. Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and Phosphatidylinositol 3 kinase
  3287. RETRACTED: Implication of Phosphatidylinositolโ€“3 kinase/Akt/glycogen synthase kinaseโ€“3ฮฒ pathway in ginsenoside Rb1โ€™s attenuation of beta-amyloid-induced โ€ฆ
  3288. A Multicenter Phase I Trial of PX-866, an Oral Irreversible Phosphatidylinositol 3โ€“kinase Inhibitor, in Patients with Advanced Solid TumorsFirst-in-Human Trial of PX โ€ฆ
  3289. Interactome mapping of the Phosphatidylinositol 3โ€“kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a โ€ฆ
  3290. โ€ฆ )/PAC1HOP1 receptor activation coordinates multiple neurotrophic signaling pathways: Akt activation through Phosphatidylinositol 3โ€“kinase ฮณ and vesicle โ€ฆ
  3291. Oncogene Ras/Phosphatidylinositol 3โ€“kinase signaling targets histone H3 acetylation at lysine 56
  3292. Novel Phosphatidylinositol 3โ€“kinase inhibitor NVP-BKM120 induces apoptosis in myeloma cells and shows synergistic anti-myeloma activity with dexamethasone
  3293. Phosphatidylinositol 3 kinase pathway and 4-hydroxy-2-nonenal-induced oxidative injury in the RPE
  3294. Activation of Phosphatidylinositol 3โ€“kinase/akt and impairment of nuclear factor-ฮบB: molecular mechanisms behind the arrested maturation/activation state of โ€ฆ
  3295. Phosphatidylinositol 3โ€“kinase ฮณ inhibition ameliorates inflammation and tumor growth in a model of colitis-associated cancer
  3296. Phosphatidylinositol 3 kinase/Akt signal relay cooperates with smad in bone morphogenetic protein-2-induced colony stimulating factor-1 (CSF-1) expression and โ€ฆ
  3297. Identification of focal adhesion kinase (FAK) and Phosphatidylinositol 3โ€kinase (PI3โ€kinase) as Par3 partners by proteomic analysis
  3298. dl-3n-Butylphthalide promotes angiogenesis via the extracellular signal-regulated kinase 1/2 and Phosphatidylinositol 3โ€“kinase/Akt-endothelial nitric oxide synthase โ€ฆ
  3299. Maternal Phosphatidylinositol 3โ€kinase signalling is crucial for embryonic genome activation and preimplantation embryogenesis
  3300. Hyperglycemia inhibits anesthetic-induced postconditioning in the rabbit heart via modulation of Phosphatidylinositolโ€“3โ€“kinase/Akt and endothelial nitric oxide โ€ฆ
  3301. Mechanism of action of the suppression of influenza virus replication by Ko-Ken Tang through inhibition of the Phosphatidylinositol 3โ€“kinase/Akt signaling pathway and โ€ฆ
  3302. 14-3โ€“3ฮถ binds class III Phosphatidylinositolโ€“3โ€“kinase and inhibits autophagy
  3303. Epithelial Phosphatidylinositolโ€“3โ€“kinase signaling is required for ฮฒ-catenin activation and host defense against Citrobacter rodentium infection
  3304. Synthesis and SAR of novel 4-morpholinopyrrolopyrimidine derivatives as potent Phosphatidylinositol 3โ€“kinase inhibitors
  3305. โ€ฆ USF1 act coordinately with FoxO to regulate expression of proapoptotic and cell cycle control genes by Phosphatidylinositol 3โ€“kinase/Akt/glycogen synthase โ€ฆ
  3306. Insulin growth factor-2 binding protein 3 (IGF2BP3) is a glioblastoma-specific marker that activates Phosphatidylinositol 3โ€“kinase/mitogen-activated protein โ€ฆ
  3307. Disruption of Platelet-Derived Growth Factorโ€“Dependent Phosphatidylinositol 3โ€“kinase and Phospholipase Cฮณ 1 Activity Abolishes Vascular Smooth Muscle Cell โ€ฆ
  3308. Class IA Phosphatidylinositol 3โ€kinase regulates osteoclastic bone resorption through protein kinase Bโ€“mediated vesicle transport
  3309. Radix Astragali extract promotes angiogenesis involving vascular endothelial growth factor receptorโ€related Phosphatidylinositol 3โ€kinase/Aktโ€dependent pathway in โ€ฆ
  3310. Integration of Phosphatidylinositol 3โ€“kinase, Akt kinase, and Smad signaling pathway in BMP-2-induced osterix expression
  3311. Effect of hydrogen sulfide on the Phosphatidylinositol 3โ€“kinase-protein kinase B pathway and on caerulein-induced cytokine production in isolated mouse pancreatic โ€ฆ
  3312. The Phosphatidylinositol 3โ€“kinase (PI3K) inhibitor LY294002 modulates cytokine expression in macrophages via p50 nuclear factor kappa B inhibition, in a PI3K โ€ฆ
  3313. Ionizing radiation up-regulates telomerase activity in cancer cell lines by post-translational mechanism via ras/Phosphatidylinositol 3โ€“kinase/Akt pathway
  3314. Cinnamic acid, from the bark of Cinnamomum cassia, regulates glucose transport via activation of GLUT4 on L6 myotubes in a Phosphatidylinositol 3โ€kinase โ€ฆ
  3315. โ€ฆ protects primary rat cortical neurons from glutamate-induced neurotoxicity via the activation of the Phosphatidylinositol 3โ€“kinase/Akt signaling pathway
  3316. Curcumin dually inhibits both mammalian target of rapamycin and nuclear factor-ฮบB pathways through a crossed Phosphatidylinositol 3โ€“kinase/Akt/IฮบB kinase complex โ€ฆ
  3317. Phase I Study of Rigosertib, an Inhibitor of the Phosphatidylinositol 3โ€“kinase and Polo-like kinase 1 Pathways, Combined with Gemcitabine in Patients with Solid โ€ฆ
  3318. Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3โ€“Phosphatidylinositol 3โ€“kinaseโ€“akt pathway through its sex hormone-binding โ€ฆ
  3319. cIAP2 Upregulated by E6 Oncoprotein via Epidermal Growth Factor Receptor/Phosphatidylinositol 3โ€“kinase/AKT Pathway Confers Resistance to Cisplatin in Human โ€ฆ
  3320. Antitumor Efficacy Profile of PKI-402, a Dual Phosphatidylinositol 3โ€“kinase/Mammalian Target of Rapamycin InhibitorPKI-402, a Dual PI3K/mTOR Inhibitor
  3321. Peptidoglycan enhances proinflammatory cytokine expression through the TLR2 receptor, MyD88, Phosphatidylinositol 3โ€“kinase/AKT and NF-kappaB pathways in BV โ€ฆ
  3322. Role of the Phosphatidylinositol 3โ€“kinase/protein kinase B pathway in regulating alternative splicing of tissue factor mRNA in human endothelial cells
  3323. FHL-2 suppresses VEGF-induced Phosphatidylinositol 3โ€“kinase/Akt activation via interaction with sphingosine kinase-1
  3324. โ€ฆ Growth and Metastatic Potential of MDA-MB-231 Breast Cancer Cells through Modulation of the Phosphatidylinositol 3โ€“kinase PathwayChemopreventive Effects of โ€ฆ
  3325. โ€ฆ Reverses the Declined Activity of Aged Ratโ€“Derived Endothelial Progenitor Cells: Involvement of the Phosphatidylinositol 3โ€“kinase/Akt Signaling Pathway
  3326. Hybrid inhibitors of Phosphatidylinositol 3โ€“kinase (PI3K) and the mammalian target of rapamycin (mTOR): design, synthesis, and superior antitumor activity of novel โ€ฆ
  3327. Activation of the Phosphatidylinositol 3โ€ฒ-kinase/AKT pathway in neuroblastoma and its regulation by thioredoxin 1
  3328. Phosphatidylinositol 3โ€ฒ-kinase signalling supports cell height in established epithelial monolayers
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