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P53

P53 is a crucial tumor suppressor protein that acts as the body’s guardian of the genome. When DNA damage occurs from environmental stresses like radiation or toxins, p53 swings into action. It can either activate DNA repair mechanisms to fix the damage, or if the damage is too severe, trigger cell suicide (apoptosis) to prevent the spread of mutations. This critical decision-making ability of p53 helps maintain genomic stability and prevents the development of cancer. In fact,mutations in the p53 gene are the most common genetic alterations found in human cancers, highlighting its vital role in keeping our cells healthy.

  1. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
  2. Human SIR2 deacetylates p53 and antagonizes PML/p53‐induced cellular senescence
  3. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
  4. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
  5. PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
  6. Regulation of cellular senescence by p53
  7. Reversal of human cellular senescence: roles of the p53 and p16 pathways
  8. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
  9. A role for both RB and p53 in the regulation of human cellular senescence
  10. Senescence and aging: the critical roles of p53
  11. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy
  12. Paradoxical suppression of cellular senescence by p53
  13. Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence
  14. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
  15. Oncogenic ras and p53 cooperate to induce cellular senescence
  16. Escape from senescence in human diploid fibroblasts induced directly by mutant p53.
  17. Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53
  18. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21CIP1, but not p16INK4a
  19. Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence
  20. JunD protects cells from p53-dependent senescence and apoptosis
  21. Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer
  22. p53, ROS and senescence in the control of aging
  23. Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction
  24. Pathways connecting telomeres and p53 in senescence, apoptosis, and cancer
  25. Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53
  26. p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC
  27. SIRT1 and p53, effect on cancer, senescence and beyond
  28. Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence
  29. Weak p53 permits senescence during cell cycle arrest
  30. The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway
  31. Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence
  32. Significant role for p16INK4a in p53-independent telomere-directed senescence
  33. Tumour suppression by p53: the importance of apoptosis and cellular senescence
  34. Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence.
  35. Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53‐dependent cellular senescence
  36. p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence
  37. DNA damage signaling and p53-dependent senescence after prolonged β-interferon stimulation
  38. Suppression of p53-dependent senescence by the JNK signal transduction pathway
  39. A two-stage, p16INK4A-and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status
  40. Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells
  41. Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform
  42. p53-independent regulation of p21Waf1/Cip1 expression and senescence by Chk2
  43. ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence
  44. Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs
  45. Hsp27 modulates p53 signaling and suppresses cellular senescence
  46. Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage
  47. Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers
  48. A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19ARF–p53 signaling
  49. p53 Mediates the accelerated onset of senescence of endothelial progenitor cells in diabetes
  50. p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer
  51. PML interaction with p53 and its role in apoptosis and replicative senescence
  52. SOCS1 links cytokine signaling to p53 and senescence
  53. The p400 E1A-associated protein is a novel component of the p53→ p21 senescence pathway
  54. Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice
  55. p53: guardian of cellular senescence
  56. From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: the telomere loss/DNA damage model of cell aging
  57. Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence
  58. Senescence regulation by the p53 protein family
  59. The M‐type receptor PLA2R regulates senescence through the p53 pathway
  60. Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence
  61. Manganese superoxide dismutase induces p53-dependent senescence in colorectal cancer cells
  62. Apoptosis or senescence-like growth arrest: influence of cell-cycle position, p53, p21 and bax in H2O2 response of normal human fibroblasts
  63. p21Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53
  64. … damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence
  65. p53-Dependent accelerated senescence induced by ionizing radiation in breast tumour cells
  66. ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation
  67. Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence
  68. http://genesdev.cshlp.org/content/16/22/2923.short
  69. CPEB regulation of human cellular senescence, energy metabolism, and p53 mRNA translation
  70. Disturbed flow promotes endothelial senescence via a p53-dependent pathway
  71. p53-dependent translational control of senescence and transformation via 4E-BPs
  72. Deregulation of oncogene‐induced senescence and p53 translational control in X‐linked dyskeratosis congenita
  73. Cellular senescence: ex vivo p53-dependent asymmetric cell kinetics
  74. Induced p53 expression in lung cancer cell line promotes cell senescence and differentially modifies the cytotoxicity of anti-cancer drugs
  75. p53 is preferentially recruited to the promoters of growth arrest genes p21 and GADD45 during replicative senescence of normal human fibroblasts
  76. Mutant p53 rescues human diploid cells from senescence without inhibiting the induction of SDI1/WAF1
  77. H2O2 accelerates cellular senescence by accumulation of acetylated p53 via decrease in the function of SIRT1 by NAD+ depletion
  78. Expression of SUMO-2/3 induced senescence through p53-and pRB-mediated pathways
  79. Cooperative interactions between RB and p53 regulate cell proliferation, cell senescence, and apoptosis in human vascular smooth muscle cells from atherosclerotic …
  80. DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence
  81. Interferon-γ induces cellular senescence through p53-dependent DNA damage signaling in human endothelial cells
  82. 5‐Lipoxygenase regulates senescence‐like growth arrest by promoting ROS‐dependent p53 activation
  83. Induction of p53-dependent senescence by the MDM2 antagonist nutlin-3a in mouse cells of fibroblast origin
  84. Definition of pRB-and p53-dependent and-independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci
  85. Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence
  86. Transient activation of p53 in G2 phase is sufficient to induce senescence
  87. A dominant role for p53-dependent cellular senescence in radiosensitization of human prostate cancer cells
  88. Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence
  89. Sodium Butyrate Induces NIH3T3 cells to senescence-like state and enhances promoter activity of p21WAF/CIP1in p53-Independent manner
  90. Chronic treatment with resveratrol induces redox stress-and ataxia telangiectasia-mutated (ATM)-dependent senescence in p53-positive cancer cells
  91. Human fibroblasts require the Rb family of tumor suppressors, but not p53, for PML-induced senescence
  92. Klotho RNAi induces premature senescence of human cells via a p53/p21 dependent pathway
  93. Caveolin-1 regulates the antagonistic pleiotropic properties of cellular senescence through a novel Mdm2/p53-mediated pathway
  94. AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy
  95. p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6
  96. Activation of p53 by nutlin-3a induces apoptosis and cellular senescence in human glioblastoma multiforme
  97. p53 and its homologues, p63 and p73, induce a replicative senescence through inactivation of NF-Y transcription factor
  98. Dynamic regulation of p53 subnuclear localization and senescence by MORC3
  99. Splicing-factor oncoprotein SRSF1 stabilizes p53 via RPL5 and induces cellular senescence
  100. The relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescence
  101. MOZ increases p53 acetylation and premature senescence through its complex formation with PML
  102. p53-dependent senescence delays Eμ-myc-induced B-cell lymphomagenesis
  103. Shifting senescence into quiescence by turning up p53
  104. Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate
  105. Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence
  106. The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence
  107. Repression of the human papillomavirus E6 gene initiates p53-dependent, telomerase-independent senescence and apoptosis in HeLa cervical carcinoma cells
  108. … papillomavirus oncoprotein E7 targets the promyelocytic leukemia protein and circumvents cellular senescence via the Rb and p53 tumor suppressor pathways
  109. p53 mediates senescence-like arrest induced by chronic replicational stress
  110. Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging
  111. Characterization of the p53 response to oncogene-induced senescence
  112. Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence
  113. Bach1 inhibits oxidative stress–induced cellular senescence by impeding p53 function on chromatin
  114. Ionizing radiation‐induced long‐term expression of senescence markers in mice is independent of p53 and immune status
  115. Control of p53 and NF-κB signaling by WIP1 and MIF: role in cellular senescence and organismal aging
  116. WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway
  117. UVB-induced senescence in human keratinocytes requires a functional insulin-like growth factor-1 receptor and p53
  118. SOCS1, a novel interaction partner of p53 controlling oncogene-induced senescence
  119. Senescence-associated alterations of cytoskeleton: extraordinary production of vimentin that anchors cytoplasmic p53 in senescent human fibroblasts
  120. Pharmacologic p53 activation blocks cell cycle progression but fails to induce senescence in epithelial cancer cells
  121. Mdm2–p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin
  122. CENP-A reduction induces a p53-dependent cellular senescence response to protect cells from executing defective mitoses
  123. Insulin‐like growth factor‐1 regulates the SIRT 1‐p53 pathway in cellular senescence
  124. Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression
  125. YPEL3, a p53-regulated gene that induces cellular senescence
  126. TGF-β signaling engages an ATM-CHK2-p53–independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial cells
  127. p53 isoforms regulate aging-and tumor-associated replicative senescence in T lymphocytes
  128. The ARF-p53 senescence pathway in mouse and human cells
  129. Nek6 overexpression antagonizes p53-induced senescence in human cancer cells
  130. An accelerated senescence response to radiation in wild-type p53 glioblastoma multiforme cells
  131. Molecular chaperones regulate p53 and suppress senescence programs
  132. Contribution of p16INK4a and p21CIP1 pathways to induction of premature senescence of human endothelial cells: permissive role of p53
  133. Indoxyl sulfate promotes vascular smooth muscle cell senescence with upregulation of p53, p21, and prelamin A through oxidative stress
  134. β-catenin expression results in p53-independent DNA damage and oncogene-induced senescence in prelymphomagenic thymocytes in vivo
  135. Hyperoxia-induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS
  136. Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p53
  137. Negative regulation of transcription factor FoxM1 by p53 enhances oxaliplatin-induced senescence in hepatocellular carcinoma
  138. Knockin mice expressing a chimeric p53 protein reveal mechanistic differences in how p53 triggers apoptosis and senescence
  139. Indoxyl sulfate induces endothelial cell senescence by increasing reactive oxygen species production and p53 activity
  140. Repression of the SUMO‐specific protease Senp1 induces p53‐dependent premature senescence in normal human fibroblasts
  141. Cooperation between p53 and p130 (Rb2) in induction of cellular senescence
  142. Resistance to UV‐induced apoptosis in human keratinocytes during accelerated senescence is associated with functional inactivation of p53
  143. Vitamin C inhibits p53-induced replicative senescence through suppression of ROS production and p38 MAPK activity
  144. Inactivation of p53 function in cultured human mammary epithelial cells turns the telomere-length dependent senescence barrier from agonescence into crisis
  145. The ATM/p53/p21 pathway influences cell fate decision between apoptosis and senescence in reoxygenated hematopoietic progenitor cells
  146. hAda3 regulates p14ARF-induced p53 acetylation and senescence
  147. Perturbation of ribosome biogenesis drives cells into senescence through 5S RNP-mediated p53 activation
  148. p53 and p16INK4A independent induction of senescence by chromatin-dependent alteration of S-phase progression
  149. Aurora A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice
  150. Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells
  151. Activation of PPARγ/p53 signaling is required for curcumin to induce hepatic stellate cell senescence
  152. MageA2 restrains cellular senescence by targeting the function of PMLIV/p53 axis at the PML-NBs
  153. Expression profiles of p53 and p66shc during oxidative stress-induced senescence in fetal bovine fibroblasts
  154. Oxidative stress-induced inhibition of Sirt1 by caveolin-1 promotes p53-dependent premature senescence and stimulates the secretion of interleukin 6 (IL-6)
  155. Telomeres, p53 and cellular senescence
  156. Ha-RasG12V induces senescence in primary and immortalized human esophageal keratinocytes with p53 dysfunction
  157. Low concentration of metformin induces a p53-dependent senescence in hepatoma cells via activation of the AMPK pathway
  158. Bcl-2 can promote p53-dependent senescence versus apoptosis without affecting the G1/S transition
  159. Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification
  160. Redox control and interplay between p53 isoforms: roles in the regulation of basal p53 levels, cell fate, and senescence
  161. Bcl-xL and E1B-19K proteins inhibit p53-induced irreversible growth arrest and senescence by preventing reactive oxygen species-dependent p38 activation
  162. Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence
  163. Expression of an IFN-inducible cellular senescence gene, IFI16, is up-regulated by p53
  164. Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?
  165. Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging
  166. Sunitinib induces cellular senescence via p53/D ec1 activation in renal cell carcinoma cells
  167. Irradiation of adult human dental pulp stem cells provokes activation of p53, cell cycle arrest, and senescence but not apoptosis
  168. SCFFbxo22-KDM4A targets methylated p53 for degradation and regulates senescence
  169. Influence of p53 and caspase 3 activity on cell death and senescence in response to methotrexate in the breast tumor cell
  170. Rb2/p130 is the dominating pocket protein in the p53–p21 DNA damage response pathway leading to senescence
  171. CLCA2 as a p53-inducible senescence mediator
  172. Culturing on Wharton’s jelly extract delays mesenchymal stem cell senescence through p53 and p16INK4a/pRb pathways
  173. Reduced mitochondrial membrane potential and altered responsiveness of a mitochondrial membrane megachannel in p53-induced senescence
  174. 20 (S)-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway
  175. Possible involvement of p21 but not of p16 or p53 in keratinocyte senescence
  176. Expression of hepaCAM is downregulated in cancers and induces senescence-like growth arrest via a p53/p21-dependent pathway in human breast cancer cells
  177. p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells
  178. Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence
  179. Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality
  180. Interstitial chromatin alteration causes persistent p53 activation involved in the radiation-induced senescence-like growth arrest
  181. Role of in Replicative Senescence and DNA Damage-Induced Premature Senescence in p53-Deficient Human Cells
  182. NORE1A is a Ras senescence effector that controls the apoptotic/senescent balance of p53 via HIPK2
  183. Autophagic degradation of the inhibitory p53 isoform Δ133p53α as a regulatory mechanism for p53-mediated senescence
  184. Induction of Cellular Senescence by Secretory Phospholipase A2 in Human Dermal Fibroblasts through an ROS-Mediated p53 Pathway
  185. p63 and p73 coordinate p53 function to determine the balance between survival, cell death, and senescence in adult neural precursor cells
  186. IGFBP-rP1 induces p21 expression through a p53-independent pathway, leading to cellular senescence of MCF-7 breast cancer cells
  187. Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence
  188. Nutlin-3, the small-molecule inhibitor of MDM2, promotes senescence and radiosensitises laryngeal carcinoma cells harbouring wild-type p53
  189. Activation of p53 with Nutlin-3a radiosensitizes lung cancer cells via enhancing radiation-induced premature senescence
  190. … peroxide induced premature senescence: senescence-associated β-galactosidase and DNA synthesis index in human diploid fibroblasts with down-regulated p53 or …
  191. Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: in vivo and in vitro evidence
  192. MDM2 inhibitor nutlin-3a induces apoptosis and senescence in cutaneous T-cell lymphoma: role of p53
  193. Replicative senescence in sheep fibroblasts is a p53 dependent process
  194. IGF-I enhances cellular senescence via the reactive oxygen species–p53 pathway
  195. The p53-p21Cip1/WAF1 pathway is necessary for cellular senescence induced by the inhibition of protein kinase CKII in human colon cancer cells
  196. Metformin and resveratrol inhibited high glucose-induced metabolic memory of endothelial senescence through SIRT1/p300/p53/p21 pathway
  197. p53-dependent induction of prostate cancer cell senescence by the PIM1 protein kinase
  198. Wnt/β-catenin signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients through the p53/p21 pathway
  199. Reactive oxygen species and p21Waf1/Cip1 are both essential for p53-mediated senescence of head and neck cancer cells
  200. Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging
  201. p53-Rb signaling pathway is involved in tubular cell senescence in renal ischemia/reperfusion injury
  202. Down‐regulation of Aurora B kinase induces cellular senescence in human fibroblasts and endothelial cells through a p53‐dependent pathway
  203. Interferon-β induces cellular senescence in cutaneous human papilloma virus-transformed human keratinocytes by affecting p53 transactivating activity
  204. Physiological ageing: role of p53 and PARP-1 tumor suppressors in the regulation of terminal senescence
  205. POZ/BTB and AT-hook-containing zinc finger protein 1 (PATZ1) inhibits endothelial cell senescence through a p53 dependent pathway
  206. Dehydroepiandrosterone inhibits the progression phase of mammary carcinogenesis by inducing cellular senescence via a p16-dependent but p53 …
  207. PML IV/ARF interaction enhances p53 SUMO-1 conjugation, activation, and senescence
  208. p53-induced autophagy and senescence
  209. Cell contact accelerates replicative senescence of human mesenchymal stem cells independent of telomere shortening and p53 activation: roles of Ras and oxidative …
  210. ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets
  211. Methylseleninic acid superactivates p53-senescence cancer progression barrier in prostate lesions of pten-knockout mouse
  212. The BRG1 ATPase of chromatin remodeling complexes is involved in modulation of mesenchymal stem cell senescence through RB–p53 pathways
  213. p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage
  214. Dexamethasone reduces sensitivity to cisplatin by blunting p53-dependent cellular senescence in non-small cell lung cancer
  215. Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal …
  216. BCL6-mediated attenuation of DNA damage sensing triggers growth arrest and senescence through a p53-dependent pathway in a cell context-dependent manner
  217. 2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-d-glucoside ameliorates vascular senescence and improves blood flow involving a mechanism of p53 deacetylation
  218. Busulfan selectively induces cellular senescence but not apoptosis in WI38 fibroblasts via a p53-independent but extracellular signal-regulated kinase-p38 mitogen …
  219. Loss of the osteogenic differentiation potential during senescence is limited to bone progenitor cells and is dependent on p53
  220. Novel ARF/p53-independent senescence pathways in cancer repression
  221. FL118 induces p53-dependent senescence in colorectal cancer cells by promoting degradation of MdmX
  222. p53 deacetylation by SIRT1 decreases during protein kinase CKII downregulation-mediated cellular senescence
  223. Induction of senescence-like phenotype and loss of paclitaxel sensitivity after wild-type p53 gene transfection of p53-null human non-small cell lung cancer H358 cells …
  224. Nucleophosmin 1, upregulated in adenomas and cancers of the colon, inhibits p53‐mediated cellular senescence
  225. Phosphatidylcholine‐specific phospholipase C, p53 and ROS in the association of apoptosis and senescence in vascular endothelial cells
  226. Suppression of the p53-dependent replicative senescence response by lysophosphatidic acid signaling
  227. Chemokine receptor CXCR 2 is transactivated by p53 and induces p38‐mediated cellular senescence in response to DNA damage
  228. Another”” Janus paradox”” of p53: induction of cell senescence versus quiescence
  229. A new p53 target gene, RKIP, is essential for DNA damage-induced cellular senescence and suppression of ERK activation
  230. … a senescence-like change via the down-regulation of SIRT1 and up-regulation of p53 protein in human esophageal squamous cancer cells with a wild-type p53 gene …
  231. A single-codon mutation converts HPV16 E6 oncoprotein into a potential tumor suppressor, which induces p53-dependent senescence of HPV-positive HeLa …
  232. Multiple facets of p53 in senescence induction and maintenance
  233. Regulation of p53 during senescence in normal human keratinocytes
  234. mTOR favors senescence over quiescence in p53-arrested cells
  235. Wild-type and Hupki (Human p53 Knock-in) Murine Embryonic Fibroblasts p53/ARF PATHWAY DISRUPTION IN SPONTANEOUS ESCAPE FROM SENESCENCE
  236. Cellular senescence induced by p53‐ras cooperation is independent of p21waf1 in murine embryo fibroblasts
  237. Role for p53 in selenium-induced senescence
  238. IGF-I induces senescence of hepatic stellate cells and limits fibrosis in a p53-dependent manner
  239. The p53/p21WAF/CIP Pathway Mediates Oxidative Stress and Senescence in Dyskeratosis Congenita Cells with Telomerase Insufficiency
  240. Arginase‐II Induces Vascular Smooth Muscle Cell Senescence and Apoptosis Through p66Shc and p53 Independently of Its l‐Arginine Ureahydrolase Activity …
  241. Be quiet and you’ll keep young: does mTOR underlie p53 action in protecting against senescence by favoring quiescence?
  242. TRIB3 promotes APL progression through stabilization of the oncoprotein PML-RARα and inhibition of p53-mediated senescence
  243. ATP‐citrate lyase regulates cellular senescence via an AMPK‐and p53‐dependent pathway
  244. Loss of BRG1 induces CRC cell senescence by regulating p53/p21 pathway
  245. … p53 codon 72 Pro/Pro genotype identifies poor-prognosis neuroblastoma patients: correlation with reduced apoptosis and enhanced senescence by the p53 …
  246. Inhibition enhancer of zeste homologue 2 promotes senescence and apoptosis induced by doxorubicin in p53 mutant gastric cancer cells
  247. CHIP-dependent p53 regulation occurs specifically during cellular senescence
  248. ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence
  249. Contribution of estrogen receptor α to oncogenic K-Ras-mediated NIH3T3 cell transformation and its implication for escape from senescence by modulating the p53 …
  250. Molecular insights into SIRT1 protection against UVB-induced skin fibroblast senescence by suppression of oxidative stress and p53 acetylation
  251. MAD2 depletion triggers premature cellular senescence in human primary fibroblasts by activating a p53 pathway preventing aneuploid cells propagation
  252. 58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway
  253. Retinoblastoma‐independent regulation of cell proliferation and senescence by the p53–p21 axis in lamin A/C‐depleted cells
  254. The regulation of cellular functions by the p53 protein: cellular senescence
  255. p53/p21 Pathway involved in mediating cellular senescence of bone marrow-derived mesenchymal stem cells from systemic lupus erythematosus patients
  256. Elevated p53 expression in benign meningiomas protects against recurrence and may be indicative of senescence
  257. p53: The pivot between cell cycle arrest and senescence
  258. RRM2B suppresses activation of the oxidative stress pathway and is up-regulated by p53 during senescence
  259. Partial proteasome inhibition in human fibroblasts triggers accelerated M1 senescence or M2 crisis depending on p53 and Rb status
  260. … suppression of HMGB1 induces cell cycle arrest and senescence in association with p21 (Waf1/Cip1) up-regulation via a p53-independent, Sp1-dependent …
  261. SIRT1 alleviates senescence of degenerative human intervertebral disc cartilage endo-plate cells via the p53/p21 pathway
  262. CARF: an emerging regulator of p53 tumor suppressor and senescence pathway
  263. VentX trans-activates p53 and p16ink4a to regulate cellular senescence
  264. Caveolin-1/PTRF upregulation constitutes a mechanism for mediating p53-induced cellular senescence: implications for evidence-based therapy of delayed wound …
  265. Cooperation between p21 and Akt is required for p53‐dependent cellular senescence
  266. Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency
  267. Numb is required to prevent p53-dependent senescence following skeletal muscle injury
  268. RNA-binding protein FXR1 regulates p21 and TERC RNA to bypass p53-mediated cellular senescence in OSCC
  269. Overexpression of the pituitary tumor transforming gene induces p53-dependent senescence through activating DNA damage response pathway in normal human …
  270. Increased expression of SIRT2 is a novel marker of cellular senescence and is dependent on wild type p53 status
  271. Arsenite induces premature senescence via p53/p21 pathway as a result of DNA damage in human malignant glioblastoma cells
  272. Serpine 1 induces alveolar type II cell senescence through activating p53‐p21‐Rb pathway in fibrotic lung disease
  273. Senescence of bone marrow mesenchymal stromal cells is accompanied by activation of p53/p21 pathway in myelodysplastic syndromes
  274. Implication of p53-dependent cellular senescence related gene, TARSH in tumor suppression
  275. … inhibitors combined with retinoic acid can enhance differentiation of neuroblastoma cells and trigger ERK-and AKT-dependent, p53-independent senescence
  276. The effects of fucodian on senescence are controlled by the p16INK4a-pRb and p14Arf-p53 pathways in hepatocellular carcinoma and hepatic cell lines
  277. BS69 is involved in cellular senescence through the p53–p21Cip1 pathway
  278. Cellular and organismal ageing: Role of the p53 tumor suppressor protein in the induction of transient and terminal senescence
  279. Simvastatin rises reactive oxygen species levels and induces senescence in human melanoma cells by activation of p53/p21 pathway
  280. The p53-reactivating small molecule RITA induces senescence in head and neck cancer cells
  281. An indirect role for ASPP1 in limiting p53‐dependent p21 expression and cellular senescence
  282. Depletion of securin induces senescence after irradiation and enhances radiosensitivity in human cancer cells regardless of functional p53 expression
  283. … S6 kinase (RSK) inhibitor BI-D1870 prevents gamma irradiation-induced apoptosis and mediates senescence via RSK-and p53-independent accumulation of …
  284. Inhibitory effect of Lycium barbarum polysaccharides on cell apoptosis and senescence is potentially mediated by the p53 signaling pathway
  285. … anti-tumor mechanisms include Hsp60 post-translational modifications leading to the Hsp60/p53 complex dissociation and instauration of replicative senescence
  286. … secreted PDZ domain-containing protein 2 (sPDZD2) induces senescence or quiescence of prostate, breast and liver cancer cells via transcriptional activation of p53
  287. Silencing of protein kinase D2 induces glioma cell senescence via p53-dependent and-independent pathways
  288. Identification of p53-dependent genes potentially involved in UVB-mediated premature senescence of human skin fibroblasts using siRNA technology
  289. Suppression of the DHX9 helicase induces premature senescence in human diploid fibroblasts in a p53-dependent manner
  290. … -glycoside-A fraction of Gonolobus condurango induces DNA damage associated senescence and apoptosis via ROS-dependent p53 signalling pathway in HeLa …
  291. Engaging the p53 metabolic brake drives senescence
  292. NQO1 stabilizes p53 in response to oncogene-induced senescence
  293. Shikonin induces apoptosis, necrosis, and premature senescence of human A549 lung cancer cells through upregulation of p53 expression
  294. Preventive Effects of Epigallocatechin-3-O-Gallate against Replicative Senescence Associated with p53 Acetylation in Human Dermal Fibroblasts
  295. mTOR inactivation by ROS-JNK-p53 pathway plays an essential role in psedolaric acid B induced autophagy-dependent senescence in murine fibrosarcoma L929 …
  296. The matricellular protein CCN1 suppresses lung cancer cell growth by inducing senescence via the p53/p21 pathway
  297. Integrated stochastic model of DNA damage repair by non-homologous end joining and p53/p21-mediated early senescence signalling
  298. Diosmin-induced senescence, apoptosis and autophagy in breast cancer cells of different p53 status and ERK activity
  299. Cell-penetrating superoxide dismutase attenuates oxidative stress-induced senescence by regulating the p53-p21Cip1 pathway and restores osteoblastic …
  300. HJURP regulates cellular senescence in human fibroblasts and endothelial cells via a p53-dependent pathway
  301. pRB, p53, p16 INK4a, senescence and malignant transformation
  302. Centrosome aberrations associated with cellular senescence and p53 localization at supernumerary centrosomes
  303. TSH overcomes BrafV600E-induced senescence to promote tumor progression via downregulation of p53 expression in papillary thyroid cancer
  304. Truncated HBx‐dependent silencing of GAS2 promotes hepatocarcinogenesis through deregulation of cell cycle, senescence and p53‐mediated apoptosis
  305. Phospholipase D2 downregulation induces cellular senescence through a reactive oxygen species–p53–p21Cip1/WAF1 pathway
  306. miR-29c-3p promotes senescence of human mesenchymal stem cells by targeting CNOT6 through p53–p21 and p16–pRB pathways
  307. Mutant lamin A links prophase to a p53 independent senescence program
  308. CUL4B impedes stress-induced cellular senescence by dampening a p53-reactive oxygen species positive feedback loop
  309. CDK2 transcriptional repression is an essential effector in p53-dependent cellular senescence—implications for therapeutic intervention
  310. Soluble egg antigens of Schistosoma japonicum induce senescence in activated hepatic stellate cells by activation of the STAT3/p53/p21 pathway
  311. HBP1-mediated regulation of p21 protein through the Mdm2/p53 and TCF4/EZH2 pathways and its impact on cell senescence and tumorigenesis
  312. Δ133p53 represses p53-inducible senescence genes and enhances the generation of human induced pluripotent stem cells
  313. Estrogens decrease γ-ray–induced senescence and maintain cell cycle progression in breast cancer cells independently of p53
  314. Knockdown of MBP-1 in human foreskin fibroblasts induces p53-p21 dependent senescence
  315. Downregulation of Polo-like kinase 1 induces cellular senescence in human primary cells through a p53-dependent pathway
  316. Secreted protein acidic and rich in cysteine-induced cellular senescence in colorectal cancers in response to irinotecan is mediated by p53
  317. Activation of adenosine receptor A2A increases HSC proliferation and inhibits death and senescence by down-regulation of p53 and Rb
  318. p53 and senescence: a little goes a long way
  319. Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling …
  320. Foxp3 is a key downstream regulator of p53-mediated cellular senescence
  321. TWEAK increases SIRT1 expression and promotes p53 deacetylation affecting human hepatic stellate cell senescence
  322. Radiosensitization of prostate cancer by priming the wild-type p53-dependent cellular senescence pathway
  323. SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes
  324. p53 suppresses stress-induced cellular senescence via regulation of autophagy under the deprivation of serum
  325. The homeobox transcription factor Prox1 inhibits proliferation of hepatocellular carcinoma cells by inducing p53-dependent senescence-like phenotype
  326. ZEB1-induced tumourigenesis requires senescence inhibition via activation of DKK1/mutant p53/Mdm2/CtBP and repression of macroH2A1
  327. Activation of p53 contributes to pseudolaric acid B-induced senescence in human lung cancer cells in vitro
  328. CARF Regulates p19ARF‐p53‐p21WAF1 Senescence Pathway by Multiple Checkpoints
  329. Mithramycin depletes specificity protein 1 and activates p53 to mediate senescence and apoptosis of malignant pleural mesothelioma cells
  330. Egg antigen p40 of Schistosoma japonicum promotes senescence in activated hepatic stellate cells by activation of the STAT3/p53/p21 pathway
  331. Knockdown of CDK2AP1 in primary human fibroblasts induces p53 dependent senescence
  332. Cr (VI) induces premature senescence through ROS-mediated p53 pathway in L-02 hepatocytes
  333. COH-203, a novel microtubule inhibitor, exhibits potent anti-tumor activity via p53-dependent senescence in hepatocellular carcinoma
  334. Jekyll and Hyde, the p53 protein, pleiotropics antagonisms and the thrifty aged hypothesis of senescence
  335. Senescence evasion in melanoma progression: uncoupling of DNA‐damage signaling from p53 activation and p21 expression
  336. Cellular senescence regulated by SWI/SNF complex subunits through p53/p21 and p16/pRB pathway
  337. Resveratrol sequentially induces replication and oxidative stresses to drive p53-CXCR2 mediated cellular senescence in cancer cells
  338. mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53
  339. Regulation of the p19Arf/p53 pathway by histone acetylation underlies neural stem cell behavior in senescence‐prone SAMP8 mice
  340. p53 and ATF-2 partly mediate the overexpression of COX-2 in H2O2-induced premature senescence of human fibroblasts
  341. Cyclopentenyl cytosine induces senescence in breast cancer cells through the nucleolar stress response and activation of p53
  342. Inhibition of p53 prevents diabetic cardiomyopathy by preventing early-stage apoptosis and cell senescence, reduced glycolysis, and impaired angiogenesis
  343. Agmatine ameliorates high glucose-induced neuronal cell senescence by regulating the p21 and p53 signaling
  344. Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung …
  345. A novel cell-penetrating peptide derived from WT1 enhances p53 activity, induces cell senescence and displays antimelanoma activity in xeno-and syngeneic …
  346. An RNA interference screen for identifying downstream effectors of the p53 and pRB tumour suppressor pathways involved in senescence
  347. Identification of a DNA Damage–Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers
  348. Mitotic centromere-associated kinase (MCAK/Kif2C) regulates cellular senescence in human primary cells through a p53-dependent pathway
  349. Depletion of CSN5 inhibits Ras-mediated tumorigenesis by inducing premature senescence in p53-null cells
  350. A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM–p53 signaling
  351. The introduction of dominant-negative p53 mutants suppresses temperature shift-induced senescence in immortal human fibroblasts expressing a thermolabile SV40 …
  352. Loss of MECP2 leads to activation of p53 and neuronal senescence
  353. Cholesterol retards senescence in bone marrow mesenchymal stem cells by modulating autophagy and ROS/p53/p21Cip1/Waf1 pathway
  354. Identification and characterization of a potent activator of p53-independent cellular senescence via a small-molecule screen for modifiers of the integrated stress …
  355. … tumor cells and glioblastoma cell lines to N, N-bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines: cell death versus p53-independent senescence
  356. NORE1A is a double barreled Ras senescence effector that activates p53 and Rb
  357. p53-dependent downregulation of hTERT protein expression and telomerase activity induces senescence in lung cancer cells as a result of pterostilbene …
  358. … mTOR pathway inhibition and autophagy induction attenuates adriamycin-induced vascular smooth muscle cell senescence through decreased expressions of p53 …
  359. Cancer-associated S100P protein binds and inactivates p53, permits therapy-induced senescence and supports chemoresistance
  360. UBTD1 induces cellular senescence through an UBTD1–Mdm2/p53 positive feedback loop
  361. The suppressed proliferation and premature senescence by ganciclovir in p53-mutated human non-small-lung cancer cells acquiring herpes simplex virus-thymidine …
  362. Shifting p53-induced senescence to cell death by TIS21/BTG2/Pc3 gene through posttranslational modification of p53 protein
  363. p53 restoration in induction and maintenance of senescence: differential effects in premalignant and malignant tumor cells
  364. … mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic …
  365. The CEACAM1 tumor suppressor is an ATM and p53-regulated gene required for the induction of cellular senescence by DNA damage
  366. p53 in bronchial club cells facilitates chronic lung inflammation by promoting senescence
  367. A p53/ARF-dependent anticancer barrier activates senescence and blocks tumorigenesis without impacting apoptosis
  368. Regulation of cellular senescence via the FOXO4‐p53 axis
  369. Resistance of primary cultured mouse hepatic tumor cells to cellular senescence despite expression of p16Ink4a, p19Arf, p53, and p21Waf1/Cip1
  370. Suppression of senescence in normal human fibroblasts by introduction of dominant-negative p53 mutants or human papilloma virus type 16 E6 protein
  371. p53-dependent senescence in mesenchymal stem cells under chronic normoxia is potentiated by low-dose γ-irradiation
  372. Glutaredoxin-1 silencing induces cell senescence via p53/p21/p16 signaling axis
  373. Combined therapies that induce senescence and stabilize p53 block melanoma growth and prompt antitumor immune responses
  374. Aberrant anaplastic lymphoma kinase activity induces a p53 and RB-dependent senescence-like arrest in the absence of detectable p53 stabilization
  375. Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program
  376. p53 shares an antigenic determinant with proteins of 92 and 150 kilodaltons that may be involved in senescence of human cells.
  377. Mechanisms of cellular senescence by tumor suppressor p53
  378. Research advances on the relationship between cell senescence and oxidative stress, p16, p53/p 21
  379. Actin-binding doliculide causes premature senescence in p53 wild type cells
  380. MicroRNA-16 feedback loop with p53 and Wip1 can regulate cell fate determination between apoptosis and senescence in DNA damage response
  381. Inhibition of Twist1-mediated invasion by Chk2 promotes premature senescence in p53-defective cancer cells
  382. LncRNA‑mediated SIRT1/FoxO3a and SIRT1/p53 signaling pathways regulate type II alveolar epithelial cell senescence in patients with chronic obstructive …
  383. Downregulation of B‐myb promotes senescence via the ROS‐mediated p53/p21 pathway, in vascular endothelial cells
  384. SIRT1 reverses senescence via enhancing autophagy and attenuates oxidative stress-induced apoptosis through promoting p53 degradation
  385. Ectopic AP4 expression induces cellular senescence via activation of p53 in long-term confluent retinal pigment epithelial cells
  386. … Not Affect the Overexpression of p21WAF‐1 after Exposure of IMR‐90 hTERT Fibroblasts to a Sublethal Concentration of H2O2 Leading to Premature Senescence
  387. Cellular senescence in mouse hippocampus after irradiation and the role of p53 and p21
  388. The PPARγ‐SETD8 axis constitutes an epigenetic, p53‐independent checkpoint on p21‐mediated cellular senescence
  389. A simple stochastic model for the feedback circuit between p16INK4a and p53 mediated by p38MAPK: implications for senescence and apoptosis
  390. Senescence process in primary Wilms’ tumor cell culture induced by p53 independent p21 expression
  391. Hydroxylated-graphene quantum dots induce cells senescence in both p53-dependent and-independent manner
  392. Accumulation of smooth muscle 22α protein accelerates senescence of vascular smooth muscle cells via stabilization of p53 in vitro and in vivo
  393. Cytoplasmic E3 ubiquitin ligase CUL9 controls cell proliferation, senescence, apoptosis and genome integrity through p53
  394. Effect of lycium bararum polysaccharides on angiotensin II-induced senescence of human umbilical vein endothelial cells and expressions of p53 and P16
  395. Gallotannin is a DNA damaging compound that induces senescence independently of p53 and p21 in human colon cancer cells
  396. Tris (2-chloroethyl) phosphate induces senescence-like phenotype of hepatocytes via the p21Waf1/Cip1-Rb pathway in a p53-independent manner
  397. Activation of p53/p21waf1 pathway is associated with senescence during v-Ha-ras transformation of immortal C2C12 myoblasts.
  398. Cyclic mechanical tension reinforces DNA damage and activates the p53-p21-Rb pathway to induce premature senescence of nucleus pulposus cells
  399. p53 levels govern the choice between senescence and quiescence
  400. Acute loss of DP1, but not DP2, induces p53 mRNA and augments p21Waf1/Cip1 and senescence
  401. Acute HSF1 depletion induces cellular senescence through the MDM2-p53-p21 pathway in human diploid fibroblasts
  402. Linking Nek6 to p53-induced senescence
  403. p41-Arc, a regulatory subunit of Arp2/3 complex, can induce premature senescence in the absence of p53 and Rb
  404. Effect of CCNB1 silencing on cell cycle, senescence, and apoptosis through the p53 signaling pathway in pancreatic cancer
  405. p53 shares an antigenic determinant with proteins of 92 and 150 kilodaltons that may be involved in senescence of human cells.
  406. Nore1a drives Ras to flick the p53 senescence switch
  407. Caveolin‑1 regulates oxidative stress‑induced senescence in nucleus pulposus cells primarily via the p53/p21 signaling pathway in vitro
  408. Hydrogen alleviates cellular senescence via regulation of ROS/p53/p21 pathway in bone marrow-derived mesenchymal stem cells in vivo
  409. Par-4-dependent p53 up-regulation plays a critical role in thymoquinone-induced cellular senescence in human malignant glioma cells
  410. Effect of silencing p53 and p21 on delaying senescence of nucleus pulposus cells
  411. Gadd45a gene silencing by RNAi promotes cell proliferation and inhibits apoptosis and senescence in skin squamous cell carcinoma through the p53 signaling …
  412. The imidazoacridinone C-1311 induces p53-dependent senescence or p53-independent apoptosis and sensitizes cancer cells to radiation
  413. LRP6 targeting suppresses gastric tumorigenesis via P14ARF–Mdm2–p53-dependent cellular senescence
  414. Immortalized mouse embryo fibroblasts are resistant to miR-290-induced senescence regardless of p53 status
  415. Correction: RNA-binding protein FXR1 regulates p21 and TERC RNA to bypass p53-mediated cellular senescence in OSCC
  416. Repeated stimulation by LPS promotes the senescence of DPSCs via TLR4/MyD88-NF-κB-p53/p21 signaling
  417. N-acetylcysteine ameliorates cisplatin-induced renal senescence and renal interstitial fibrosis through sirtuin1 activation and p53 deacetylation
  418. Role of p53-senescence induction in suppression of LNCaP prostate cancer growth by cardiotonic compound bufalin
  419. CSL-p53: From senescence to CAF activation
  420. Farnesyltransferase inhibitor induces p53-dependent cellular senescence in colon cancer cells
  421. PGE2 mediates senescence-induced inflammation in COPD lung fibroblasts via an EP2/p53 pathway
  422. Abstract B1: p53 isoforms, Δ133p53 and p53β, regulate aging-associated T lymphocyte senescence.
  423. The Influence of Overexpression of Wild Type p53 and UVB Radiation on Senescence of Human Skin Fibroblasts [J]
  424. Abstract A06: NORE1A is a double-barreled Ras senescence effector linking Ras to p53 and Rb
  425. Effect of microRNA-34a/SIRT1/p53 signal pathway on notoginsenoside R₁delaying vascular endothelial cell senescence
  426. Excess centrosomes induce p53-dependent senescence without DNA damage in endothelial cells
  427. Pharmacological DNA-PK inhibition induces ATM/p53 dependent premature senescence with immunomodulatory phenotype in irradiated cancer cells
  428. ASF1a inhibition induces p53-dependent growth arrest and senescence of cancer cells
  429. The p53/miRNAs/Ccna2 pathway serves as a novel regulator of cellular senescence: Complement of the canonical p53/p21 pathway
  430. … of human melanocytes to UVB twice and subsequent incubation leads to cellular senescence and senescence-associated pigmentation through the prolonged p53 …
  431. Differential radiation sensitivity in p53 wild-type and p53-deficient tumor cells associated with senescence but not apoptosis or (nonprotective) autophagy
  432. ALDH2 mediates the dose-response protection of chronic ethanol against endothelial senescence through SIRT1/p53 pathway
  433. Interleukin‑10 promotes primary rat hepatic stellate cell senescence by upregulating the expression levels of p53 and p21
  434. WITHDRAWN: Hexavalent chromium induces premature senescence through reactive oxygen species-mediated p53 pathway in L-02 hepatocytes
  435. Combined treatment with CCI779 and SB203580 induces cellular senescence in renal cell carcinoma cell line via p53 pathway
  436. Conjugated Physiological Resveratrol Metabolites Induce Senescence in Breast Cancer Cells: Role of p53/p21 and p16/Rb Pathways, and ABC Transporters
  437. Upregulation of MiR-126 Delays the Senescence of Human Glomerular Mesangial Cells Induced by High Glucose via Telomere-p53-p21-Rb Signaling Pathway
  438. Transcription of the tumor suppressor genes p53 and RB in lymphocytes from patients with chronic kidney disease: evidence of molecular senescence?
  439. … species induced by the compound bisphenol-a-diglycidylether cause senescence and apoptosis in colorectal cancer cell lines regardless of MDR1 or p53 …
  440. p53 restoration leads to tumor senescence and regression: implications for cancer therapy
  441. 23 SV40 oncoproteins and p53 deficiency impair stress-induced mesothelial cell senescence
  442. Senescence. Telomere, mitochondria and p53
  443. Methylseleninic acid super-activates p53 senescence axis as a preventive barrier to prostate tumorigenesis driven by Pten deficiency in vivo.
  444. p53 isoform delta133p53 in tumor senescence
  445. Comparative induction of p53-regulated gene expression by replicative senescence, pharmacological senescence, and DNA damage
  446. Inflammation, senescence and cancer: interweaving microRNA, inflammatory cytokines and p53 networks
  447. The role of Mip130/LIN-9, a cell cycle regulator, in the p19ARF/MDM2/p53 senescence pathway
  448. Role of mitochondria elongation in p53-induced cellular senescence
  449. Overexpression of MnSOD induces mitochondrial depolarization and p53-dependent senescence
  450. Critical roles of p53 and p16 in selenium-induced senescence
  451. Abstract A20: Excess centrosomes induce p53-dependent senescence in endothelial cells
  452. Cigarette Smoke Induces Cellular Senescence Via p53-Mediated Werner’s Syndrome Protein
  453. Abstract B30: Identification of new regulator in p53-mediated cellular senescence
  454. 1, 25‐Dihydroxyvitamin D exerts an antiaging role by activation of Nrf2‐antioxidant signaling and inactivation of p16/p53‐senescence signaling
  455. p53 gene expression is epigenetically regulated during replicative senescence in keratinocytes
  456. Inflammation, senescence and cancer: interweaving microRNA, inflammatory cytokines and p53 networks
  457. p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence
  458. Vitamin C inhibits p53-induced senescence by preventing ROS generation and p38 MAPKinase activation
  459. The role of p53 induced cellular senescence in age related disorders.
  460. Hyperoxic Exposure Increases Senescence in Type II-Like Mouse Lung Epithelial Cells: Role of p53 Signaling
  461. Rapid senescence induced by overexpression of p53 in NIH3T3 cells
  462. Abstract# SY15-4: Functions of p53 in cell senescence and survival
  463. CS-33DISCOVERY OF A p53-INDEPENDENT SUPPRESSOR OF SENESCENCE OF GLIOBLASTOMA MULTIFORME
  464. Transient p53-Mediated Regenerative Senescence in the Injured Heart
  465. Influence of RNA interference-induced repression of p53 expression on senescence in human skin fibroblasts
  466. SENP3 Postpones Cellular Senescence of p53-mediated Pathway under Mild Oxidative Stress
  467. p53-dependent, replicative cell senescence suppresses chronic hypoxia-Induced pulmonary hypertension in mice
  468. p53 action in apoptosis and senescence
  469. Activation of p53 by radiation and induction of senescence-like growth arrest
  470. The role of the p53 target Wig-1 in senescence and cancer
  471. Abstract SY14-02: p53-mediated senescence impairs the apoptotic response to chemotherapy in breast cancer
  472. Molecular Mechanisms of p53-and ROS-induced senescence
  473. Abstract# 1702: Molecular basis for the accelerated senescence response to doxorubicin in p53 wild-type and p53 null/mutant breast tumor cells.
  474. Sirt1 antagonizes Stra13 Mediated p53 Acetylation and Senescence
  475. Role of p53 in Mammary Epithelial Cell Senescence
  476. Loss of Adipocyte MDM2 Causes Lipodystrophy by Inducing p53-Dependent Apoptosis and Senescence
  477. Supplemental Data Significant Role for p16INK4a in p53-Independent Telomere-Directed Senescence
  478. The p53-MDM2-Rb network in controlling cell growth, apoptosis and senescence
  479. TAp63 induces cellular senescence and blocks Ras-driven tumor formation through p53-depdendent and-indepdendent mechanisms
  480. The role of DEC1 in p53-dependent cellular senescence
  481. P19 ARF-p53 Tumor Suppressor Pathway During Oncogene-Induced Apoptosis and Senescence
  482. Differential efficacy of p53 restoration in induction and maintenance of senescence in premalignant and malignant cells
  483. p53 induces senescence in the unstable progeny of aneuploid cells
  484. Bisphenol A exposure under metabolic stress induces accelerated cellular senescence in vivo in a p53 independent manner
  485. Identification of novel p53-target genes and their physiological roles in tumor suppression and cellular senescence.
  486. A novel DNA damage-induced alternative splicing pathway that regulates p53 and cellular senescence markers
  487. Cellular Senescence Controlled by p53 is a Barrier to Environmental Carcinogenesis
  488. p53 restoration in liver carcinomas induces cellular senescence and tumor clearance through an innate immune response
  489. Modulating Effects and Mechanisms of p53-miR-34a-SIRT1 Feedback Loop on Reproductive Senescence of Vascular Endothelial Progenitor Cells
  490. Cellular senescence as a tumor suppressor mechanism is mediated by sequential activation of the p53 and RB pathways
  491. p53-dependent stromal senescence-induced tumor dormancy in the pre-metastatic reservoir thymus
  492. Genome–Epigenome–Senescence: Is TET1 a Caretaker of p53-Injured Lung Cancer Cells?
  493. … DECISIONS: SENESCENCE, REPAIR, AND REGENERATION: Plasminogen Activator Inhibitor-1 Induces Alveolar Type 2 Cell Senescence Through Activating p53 …
  494. Abstract A33: A whole genome RNAi screen identifies BRD7 and BAF180 as p53 regulators required for senescence
  495. Abstract PR08: Autophagic degradation of Δ133p53 during replicative cellular senescence: An isoform-specific protein degradation mechanism for p53
  496. Id4 acts as a tumor suppressor by inducing apoptosis and senescence in p53-dependent manner
  497. Overexpression of the 58-kDa microspherule protein (MSP58) triggers cellular senescence via the p53-p21 signaling axis
  498. ITGB 4 deficiency induces senescence of airway epithelial cells through p53 activation
  499. p53 induces senescence through Lamin A/C stabilization-mediated nuclear deformation
  500. Correction: NLRP6 targeting suppresses gastric tumorigenesis via P14ARF–Mdm2–p53-dependent cellular senescence
  501. The Mdm2-a splice variant alters development, lifespan, cellular growth and senescence in a p53-dependent manner
  502. Targeting NEK2 Induces Cellular Senescence in B-Cell Malignancies through p53-Independent Signaling Pathways
  503. Olaparib induced senescence under P16 or p53 dependent manner in ovarian cancer
  504. Synaptotagmin-7, a binding protein of p53, inhibits the senescence and promotes the tumorigenicity of lung cancer cells
  505. Plasminogen Activator Inhibitor-1 Induces Alveolar Type 2 Cell Senescence Through Activating p53-P21-Rb Pathways In Vitro And In Vivo
  506. Dissecting the function of p53 in cellular senescence by identification and characterization of p53 target genes
  507. CARF Regulates Cellular Senescence and Apoptosis through p53-Dependent and-Independent Pathways
  508. Loss of MECP2 leads to induction of p53 and cell senescence
  509. Susceptibility to Radiation Induced Apoptosis and Senescence in p53 Wild Type and p53 Mutant Breast Tumor Cells
  510. Coagulation Factor Xa Promotes Endothelial Cell Senescence Via p53 Up-regulation
  511. Abstract SY02-02: Tumor suppression in the absence of p53-mediated cell cycle arrest, apoptosis, and senescence.
  512. Notch Signaling Regulates Vascular Endothelial Cell Senescence via a p53-Dependent Pathway
  513. Chromatin interacting proteins RBL2/p130, MRG15 and p53 in cellular senescence
  514. p53 Isoforms in Cellular Senescence-and Ageing-Associated Biological and Physiological Functions
  515. Oncogene-induced senescence and the role of p53 in BRAFV600E melanoma
  516. Ionizing radiation-induced senescence of breast tumor cells is dependent on p53 and associated with telomere dysfunction.
  517. Sharp-1 Mediates p53-dependent cellular senescence through antagonism of Sirt1
  518. Hsp90β interacts with MDM2 to suppress p53‐dependent senescence during skeletal muscle regeneration
  519. p53 regulates mitochondrial dynamics by inhibiting Drp1 translocation into mitochondria during cellular senescence
  520. … RECEPTOR BLOCKER, FIMASARTAN REDUCES VASCULAR SMOOTH MUSCLE CELL SENESCENCE BY INHIBITING CYR61 AND ERK/P38MAPK/p53 …
  521. Abstract# 3478: Diminution of p53 during cellular senescence and organismal aging in normal human keratinocytes occurs at the post-transcriptional level
  522. MDM2-mediated degradation of WRN promotes cellular senescence in a p53-independent manner
  523. P4500 Cellular senescence of endothelial cells impairs angiogenesis by altering energy metabolism through p53-tigar axis
  524. Induction of p53 Dependent Cellular Senescence Through HdmX Inhibition or YPEL3 Expression
  525. TIS21/BTG2/PC3 triggers cancer cell death, instead of cellular senescence, by enhancing proapoptotic gene expression at the downstream of p53
  526. A retroviral tamoxifen-inducible human Tp53ER protein activates a conserved p53 response but fails to promote senescence in mouse fibroblasts
  527. Human colorectal cancer derived-MSCs promote tumor cells escape from senescence via p53/P21 pathway
  528. Depletion of GAPDH promotes p53 signaling, cell senescence and altered response to chemotherapeutic agents in human carcinoma cells
  529. In Cellular Senescence, the Third Circle of the Cell Life’s Network, p53 Acts Vital Role
  530. Induction of p53-mediated senescence is essential for the eventual anticancer therapeutic effect of RH1
  531. Abstract# 3473: Down regulation of HDAC2 in senescent fibroblasts involves cellular senescence through induction of p53 independent p21cip1/sdi1 transactivation
  532. TIS21 shifts p53-induced response of EJ bladder carcinoma cells from senescence to apoptosis
  533. Depletion of TRRAP induces p53‐independent senescence in liver cancer by downregulating mitotic genes
  534. 17β-estradiol inhibits human umbilical vascular endothelial cell senescence by regulating autophagy via p53
  535. The Kindlin2-p53-SerpinB2 signaling axis is required for cellular senescence in breast cancer
  536. Corrigendum: Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence …
  537. Abstract LB-082: The Kindlin2-p53-SerpinB2 signaling axis is required for the regulation of cellular senescence in breast cancer
  538. l-Carnitine inhibits the senescence-associated secretory phenotype of aging adipose tissue by JNK/p53 pathway
  539. ID: 1051 Telomerase activity, telomere length and p53 mutation detection on cellular senescence of Human Amnion Mesenchymal Stem Cells (HAMCs)
  540. Time-dependent p53 inhibition determines senescence attenuation and long-term outcome after renal ischemia-reperfusion
  541. The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1
  542. Influence of RNA interference in p53 gene on the expressions of genes involved in ultraviolet B-induced premature senescence and photocarcinogenesis in human …
  543. Involvement of p53 in senescence arrest and caspase 3 activity in the cell death response to methotrexate in the breast tumor cell
  544. Inhibition of DYRK1A-EGFR axis by p53-MDM2 cascade mediates the induction of cellular senescence
  545. … II-INDUCED CELLULAR SENESCENCE IN HUMAN CORONARY ARTERY SMOOTH MUSCLE CELLS BY INHIBITING CYR61 AND ERK/P38MAPK/p53 SIGNALING …
  546. … MECHANISMS THAT LINK AGING WITH LUNG DISEASE: THE CUTTING EDGE: Acrolein Induces p53-Mediated Cellular Senescence Accompanied By Enhanced …
  547. CALB1 enhances the interaction between p53 and MDM2, and inhibits the senescence of ovarian cancer cells
  548. Induction of a p21 mediated senescence program by p53 impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer
  549. Atrial Fibrillation Progression Is Associated with Cell Senescence Burden as Determined by p53 and p16 Expression
  550. Retraction: Interferon-β Induces Cellular Senescence in Cutaneous Human Papilloma Virus-Transformed Human Keratinocytes by Affecting p53 Transactivating …
  551. Possible role of cellular senescence in the pathogenesis of psoriasis–expression of 53BP1, γH2AX, p16, p21 and p53 in lesional psoriatic skin
  552. Methotrexate-induced senescence of human colon cancer cells depends on p53 acetylation, but not genomic aberrations
  553. BMI1 and dominant negative p53 cooperate to suppress AKT-mediated oncogene-induced senescence and promote transformation in human neural stem cells.
  554. PM 10 from Mexico City (MC) induce senescence-like phenotype and ATM, γH2A. X and p53 activation linked to oxidative stress
  555. Vascular Senescence Promotes the Development of Insulin Resistance: Role of Endothelial p53 in Glucose Metabolism
  556. Interleukin-10 induces senescence of activated hepatic stellate cells via STAT3-p53 pathway to attenuate liver fibrosis
  557. Decline of p300 contributes to cell senescence and growth inhibition of hUC-MSCs through p53/p21 signaling pathway
  558. P4239Bradykinin inhibits High Glucose-Induced Senescence of c-kit Positive Cardiac Stem Cells via B2R/PI3K/AKT/mTOR/p53 signal pathway
  559. Small molecule inhibitor of MDM2 induces p53-dependent HMGB1 secretion followed by apoptosis in cancer cells and incomplete senescence in normal fibroblasts
  560. Sirtuin 2 expression suppresses oxidative stress and senescence of nucleus pulposus cells through inhibition of the p53/p21 pathway
  561. circ LARP 4 induces cellular senescence through regulating miR‐761/RUNX 3/p53/p21 signaling in hepatocellular carcinoma
  562. 20 (S)-Ginsenoside Rg3 Promotes Senescence And Apoptosis In Gallbladder Cancer Cells Via The p53 Pathway [Corrigendum]
  563. Abstract A060: Inhibition of Aurora B kinase activity triggers senescence that can be bypassed by blocking p53 and RB function, promoting replication stress
  564. Wild-type p53-induced phosphatase 1 (Wip1) prevents cellular senescence at physiological oxygen levels by regulating DNA damage signaling during DNA …
  565. MicroRNA‐145 induces the senescence of activated hepatic stellate cells through the activation of p53 pathway by ZEB2
  566. Negative regulation of p53-induced senescence by N-WASP is crucial for DMBA/TPA-induced skin tumor formation
  567. Avenanthramide A Induces Cellular Senescence via miR-129-3p/Pirh2/p53 Signaling Pathway To Suppress Colon Cancer Growth
  568. Abstract P1-04-03: A Role for Cyclin D1 in Neoplastic Transformation in MCF-7 Breast Cancer Cells Post p14ARF-p53 Induced Senescence
  569. Mitotic catastrophe and p53-dependent senescence induction in T-cell malignancies exposed to nonlethal dosage of GL-V9
  570. Upregulation of the p53-p21 pathway by G2019S LRRK2 contributes to the cellular senescence and accumulation of α-synuclein
  571. p53 loss does not permit escape from BrafV600E-induced senescence in a mouse model of lung cancer
  572. Jun dimerization protein 2 controls hypoxia‐induced replicative senescence via both the p16Ink4a‐pRb and Arf‐p53 pathways
  573. Caveolin-1 mediated p53 activation in stress induced premature senescence and its antagonistic pleiotropic implications in cancer
  574. 0359: Cyclosporine A prevents the induction of replicative senescence in cultured coronary artery endothelial cells: role of eNOS-derived NO and the p53/p21 and p16 …
  575. The p53-p21 pathway is necessary for cellular senescence induced by the inhibition of protein kinase CKII in human colon cancer cells.
  576. TDF-ß signaling engages an ATM-CHK2-p53-independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial …
  577. Dephosphorylation of p53 Ser 392 Enhances Trimethylation of Histone H3 Lys 9 via SUV39h1 Stabilization in CK2 Downregulation-Mediated Senescence
  578. Supplemental Data Telomere Shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a
  579. Role of tea polyphenols in delaying hyperglycemia-induced senescence in human glomerular mesangial cells via miR-126/Akt–p53–p21 pathways
  580. The synergistic action of phosphate and interleukin-6 enhances senescence-associated calcification in vascular smooth muscle cells depending on p53
  581. Insulin-like growth factor-1 attenuates oxidative stress-induced hepatocyte premature senescence in liver fibrogenesis via regulating nuclear p53–progerin …
  582. Abstract C34: Senescence as a mechanism of resistance to the Aurora kinase and angiokinase inhibitor, ENMD-2076, in p53 mutated triple-negative breast cancer …
  583. C2-Ceramide-Induced Rb-Dominant Senescence-Like Phenotype Leads to Human Breast Cancer MCF-7 Escape from p53-Dependent Cell Death
  584. Loss of Cdh1 Triggers Premature Senescence in Part via Activation of Both the RB/E2F1 and the CLASPIN/CHK1/p53 Tumor Suppressor Pathways
  585. … anti-TOPO-1-containing sera from systemic sclerosis-related diseases with Raynaud’s phenomenon induce vascular endothelial cell senescence not via classical p53 …
  586. TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 …
  587. Roberson RS, Kussick SJ, Vallieres E, Chen SY, Wu DYEscape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in …
  588. Epigenetic regulation and molecular mechanisms of cellular senescence by tumor suppressor p53
  589. Editorial comment on ‘A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy’by Schmitt et al.
  590. However, cells that use Myc or loss of RB/p53 to circumvent senescence will eventually experience rampant genome instability due to the loss of their …
  591. Hyperglycemia-induced endothelial senescence mediated by the p53 deacetylase SIRT1 contributes to diabetic vasculopathy
  592. … EGFR and Mutant p53 Facilitates Epithelial-Mesenchymal Transition By Negating Oncogene-Activated Cellular Senescence in Transformed Human …
  593. OC-0050: Radiation-induced endothelial senescence is under the control of p53 and mitochondrial dysfunction
  594. Replicative Senescence of Human Oral Keratinocytes, Telomerase, Telomere, p53 and p21WAF¹/CIP¹
  595. P180 HEME OXYGENASE-1 PREVENTS VASCULAR SENESCENCE THROUGH MECHANISMS INVOLVING ROS/SIRT1/p53 PATHWAY IN AGED …
  596. Mo1744–Nlrp6 Targeting Suppresses Colonic Tumorigenesis Via p53-Dependent and Independent Cellular Senescence
  597. Sa1790 p53-Dependent Senescence Suppresses the Proliferation of Esophageal Epithelial Cells With Acetaldehyde-Derived DNA Damage
  598. Sa1715 Regulation of Cellular Senescence by the microRNA-34a/p53 Axis During Alcoholic Liver Injury
  599. Acrolein Induces p53-Mediated Cellular Senescence Accompanied By Enhanced Werner’s Syndrome Protein Degradation And Telomere Shortening
  600. H2O2 accelerates cellular senescence by accumulation of acetylated p53 via decrease in the function of SIRT1 by NAD [+] depletion
  601. Induction of Premature Senescence in Cardiomyocytes by Oxidative Stress Via PML-acetylated p53 Pathway in Cardiomyocytes
  602. p53 restoration in liver carcinomas induces cellular senescence and tumor clearance through an innate immune response
  603. CHIP ligase plays a central role in p53 regulation during senescence
  604. Altered expression of p53 ubiquitin ligases in human senescence
  605. 217 Localization of Phosphorylated H2AX and Phosphorylated p53 in Cells Inducing X-ray-induced Senescence-like Growth Arrest (Physics, chemistry …
  606. Telomere function and p16/RB and p53-mediated senescence pathways in human cancer
  607. Partial proteasome inhibition triggers p53-dependent premature senescence
  608. CARF is a novel regulator of p53 pathway that controls senescence and apoptosis
  609. RB and p53 Regulate Cell Proliferation, Cell Senescence and Apoptosis in Human Vascular Smooth Muscle Cells from Atherosclerotic Plaques
  610. ARF, p53 AND THE CONTROL OF CELLULAR SENESCENCE IN MOUSE MELANOCYTES.
  611. PJ-149 Hyperglycemia-induced Senescence of Endothelial Cells through the p53 Deacetylase SIRT1 (Diabetes/Obesity/Metabolic syndrome-10 (H) PJ25 …
  612. Protein Kinase CKII Inhibition-Induced Senescence is p53-Dependent
  613. … A Induces DNA Double Strand Break and Activates the ATM-p53-GDF15 Signaling Pathway Leading to Cell Cycle Arrest and Senescence in Human Fetal …
  614. FRS-071 Premature Senescence can be Induced by Oxidative Stress via PML-p53 Acetylation Pathway in Cardiomyocytes (Heart Failure Research (M) …
  615. mTOR directly phosphorylates p53 in PTEN-loss-induced cellular senescence
  616. ISDN2014_0058: p63 and p73 coordinate p53 function to determine the balance between survival, cell death and senescence in adult neural precursor …
  617. The relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescence
  618. GW29-e0204 Bradykinin Inhibits High-Glucose-Induced Senescence of Cardiac Progenitor Cells through the B2R/PI3K/AKT/mTOR/p53 Signal Pathways
  619. Senescence-related expression of p53 ligases
  620. Study on the mechanism of p53 family-mediated senescence= p53 단백질군에 의한세포노화의 기작에 관한 연구
  621. TIS21 shifts H-RasV12 oncogene-induced senescence to apoptosis in EJ bladder cancer cells in a p53 dependent manner
  622. p53 expression in the senescence induced with H2O2 in gastric epithelial cell
  623. Localization of Phosphorylated H2AX and Phosphorylated p53 in Cells Inducing X-ray-induced Senescence-like Growth Arrest
  624. Imidazoacridinone derivative C-1311 (SymadexTM) induces apoptosis, mitotic catastrophe or senescence in human colon carcinoma HCT116 cells depending on p53 …
  625. SCF (Fbxo22)-KDM4A targets methylated p53 for degradation and regulates senescence (細胞老化過程における p53 標的遺伝子 Fbxo22 の機能解析)< 内容の…
  626. 4-methyl-1-nitroacridine derivative C-1748 induces apoptosis, mitotic catastrophe or senescence in human colon carcinoma HCT116 cells depending on p53 status
  627. Transcriptional coactivator Sp110 associates with p53 and regulates p53-dependent cellular senescence
  628. Aging & Cellular Senescence: A Molecular Mechanism of p53-induced Senescence
  629. … and Cancer: RHI, a bioreductive agent exerts its anti-cancer effect through both apoptosis and senescence accompanied with marked induction of p53
  630. Akt Induces Endothelial Cell Senescence via a p53/p21-Dependent Pathway
  631. p53 codon 72 polymorphism and longevity: additional data on centenarians from continental Italy and Sardinia
  632. Why do centenarians escape or postpone cancer? The role of IGF-1, inflammation and p53
  633. p53 variants predisposing to cancer are present in healthy centenarians.
  634. Metabolic gene polymorphisms and p53 mutations in healthy centenarians and younger controls
  635. Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21‐dependent pathway
  636. New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53−/− mice by delaying carcinogenesis
  637. New tricks of an old molecule: lifespan regulation by p53
  638. p53/CEP‐1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress
  639. Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms
  640. Loss of p53 function accelerates acquisition of telomerase activity in indefinite lifespan human mammary epithelial cell lines
  641. Sequential extension of proliferative lifespan in human fibroblasts induced by over-expression of CDK4 or 6 and loss of p53 function
  642. Cockayne syndrome B protein (CSB): linking p53, HIF-1 and p300 to robustness, lifespan, cancer and cell fate decisions
  643. Systemic Akt1 deletion after tumor onset in p53−/− mice increases lifespan and regresses thymic lymphoma emulating p53 restoration
  644. Impaired p53/CEP‐1 is associated with lifespan extension through an age‐related imbalance in the energy metabolism of C. elegans
  645. The late effects of radiation on lifespan, lymphocyte proliferation and p53 haplodeficiency in mice
  646. Polμ deficiency induces moderate shortening of p53−/− mouse lifespan and modifies tumor spectrum
  647. The Mdm2-a splice variant alters development, lifespan, cellular growth and senescence in a p53-dependent manner
  648. Results-II. Haploinsufficiency of p53 Rescues Lifespan and Premature Aging-Associated Abnormalities in Sirt6-Deficient Mice
  649. AKT NEGATIVELY REGULATES HUMAN ENDOTHELIAL CELL LIFESPAN VIA THE p53/P21 DEPENDENT PATHWAY
  650. Akt negatively regulates the in vitro lifespan of human endothelial Cells via a p53/p21-dependent pathway
  651. The effects of p53 on whole organism longevity are mediated by autophagy
  652. p53: guardian AND suppressor of longevity?
  653. Tumor suppressor p53 Arg72Pro polymorphism and longevity, cancer survival, and risk of cancer in the general population
  654. The common germline Arg72Pro polymorphism of p53 and increased longevity in humans
  655. p53: Pro-aging or pro-longevity?
  656. The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor
  657. Reduced Expression of the Caenorhabditis elegans p53 Ortholog cep-1 Results in Increased Longevity
  658. The regulation of aging and longevity: a new and complex role of p53
  659. p53 codon 72 polymorphism and longevity: additional data on centenarians from continental Italy and Sardinia
  660. The p53–Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity
  661. Using mice to examine p53 functions in cancer, aging, and longevity
  662. Altered longevity‐assurance activity of p53: p44 in the mouse causes memory loss, neurodegeneration and premature death
  663. Lower antioxidant capacity and elevated p53 and p21 may be a link between gender disparity in renal telomere shortening, albuminuria, and longevity
  664. Rapamycin as longevity enhancer and cancer preventative agent in the context of p53 deficiency
  665. A role for p53 in mitochondrial stress response control of longevity in C. elegans
  666. Longevity regulation in flies: a role for p53
  667. CEP-1, the Caenorhabditis elegans p53 homolog, mediates opposing longevity outcomes in mitochondrial electron transport chain mutants
  668. Sir2 and longevity: the p53 connection
  669. P44, the ‘longevity‐assurance’isoform of p53, regulates tau phosphorylation and is activated in an age‐dependent fashion
  670. p53, longevity assurance and longevity suppression
  671. Transcription factors CEP‐1/p53 and CEH‐23 collaborate with AAK‐2/AMPK to modulate longevity in Caenorhabditis elegans.
  672. Germline genetics of the p53 pathway affect longevity in a gender specific manner
  673. Are the conspicuous interdependences of fecundity, longevity and cognitive abilities in humans caused in part by p53?
  674. A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models
  675. p53: Pro-aging or pro-longevity?
  676. The impact of p53 codon 72 SNP upon aging and longevity in mouse models
  677. Role of p53 in Extending Longevity in Untransformed Fibroblasts
  678. On the discovery and elucidation of the mechanism via which repression of the Caenorhabditis elegans p53 ortholog cep-1 results in longevity.
  679. Sirtuin1, a longevity gene, is over-expressed and enhances proliferation and survival of endometrial carcinoma cells via deacetylation of p53.
  680. On the discovery and elucidation of the mechanism via whichrepression of the Caenorhabditis elegans p53 ortholog cep-1 results in longevity
  681. Elephants, longevity, cancer and p53
  682. Glutathione depletion induces antioxidant response via the p53-mediated transcription of PGC-1a: a novel longevity pathway?
  683. Two faces of p53: aging and tumor suppression
  684. Senescence and aging: the critical roles of p53
  685. The p53 network: cellular and systemic DNA damage responses in aging and cancer
  686. Does p53 affect organismal aging?
  687. p53, ROS and senescence in the control of aging
  688. p53, oxidative stress, and aging
  689. Increased p53 protein associated with aging in human diploid fibroblasts
  690. Tumor suppression and normal aging in mice with constitutively high p53 activity
  691. The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging
  692. The Arf/p53 pathway in cancer and aging
  693. The tumor suppressor p53: cancer and aging
  694. Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform
  695. ATM‐dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post‐translational activation of p53 protein involving poly (ADP‐ribose) …
  696. Aging and chronic DNA damage response activate a regulatory pathway involving miR‐29 and p53
  697. Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program
  698. Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations
  699. From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: the telomere loss/DNA damage model of cell aging
  700. p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice
  701. p53: Pro-aging or pro-longevity?
  702. p53 as an intervention target for cancer and aging
  703. The regulation of aging and longevity: a new and complex role of p53
  704. DNA repair and aging: the impact of the p53 family
  705. Wnt/β-catenin signaling induces the aging of mesenchymal stem cells through the DNA damage response and the p53/p21 pathway
  706. Mdm2–p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin
  707. Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging
  708. p53 and aging: A fresh look at an old paradigm
  709. Accelerated development and aging of the immune system in p53-deficient mice
  710. Insights into aging obtained from p53 mutant mouse models
  711. Control of p53 and NF-κB signaling by WIP1 and MIF: role in cellular senescence and organismal aging
  712. Using mice to examine p53 functions in cancer, aging, and longevity
  713. p53 isoforms regulate aging-and tumor-associated replicative senescence in T lymphocytes
  714. Fragile fugue: p53 in aging, cancer and IGF signaling
  715. Complicating the role of p53 in aging
  716. Sun-exposure-and aging-dependent p53 protein accumulation results in growth advantage for tumour cells in carcinogenesis of nonmelanocytic skin cancer
  717. Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging
  718. Cancer and aging: yin, yang, and p53.
  719. Glycolysis links p53 function with NF‐κB signaling: Impact on cancer and aging process
  720. DNA sequence variants of p53: cancer and aging
  721. Aging-associated truncated form of p53 interacts with wild-type p53 and alters p53 stability, localization, and activity
  722. Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 3. Inhibitory effect of SkQ1 on tumor development from p53 …
  723. p53 induces skin aging by depleting Blimp1+ sebaceous gland cells
  724. Oxidative damage to DNA, p53 gene expression and p53 protein level in the process of aging in rat brain
  725. Aging splenocyte and thymocyte apoptosis is associated with enhanced expression of p53, bax, and caspase-3
  726. cep-1/p53-dependent dysplastic pathology of the aging C. elegans gonad
  727. p53 pro-oxidant activity in the central nervous system: implication in aging and neurodegenerative diseases
  728. Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging
  729. p53 mutations associated with aging-related rise in cancer incidence rates
  730. Pharmacogenetics and pharmagenomics, trends in normal and pathological aging studies: focus on p53
  731. Interaction between the Cockayne syndrome B and p53 proteins: implications for aging
  732. Recent discoveries in the cycling, growing and aging of the p53 field
  733. Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors
  734. It’s all about balance: p53 and aging
  735. Apurinic/apyrimidinic endonuclease 1, p53, and thioredoxin are linked in control of aging in C. elegans
  736. Anxiety and the aging brain: Stressed out over p53?
  737. Tumor suppression by p53 without accelerated aging: just enough of a good thing?
  738. Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner
  739. SnoN activates p53 directly to regulate aging and tumorigenesis
  740. Dysfunction of the MDM2/p53 axis is linked to premature aging
  741. Relationship of telomeres and p53 in aging bovine corneal endothelial cell cultures
  742. Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming
  743. Increased Arf/p53 activity in stem cells, aging and cancer
  744. Loss of androgen receptor in aging and oxidative stress through Myb protooncoprotein-regulated reciprocal chromatin dynamics of p53 and poly (ADP-ribose) …
  745. FGF21 represses cerebrovascular aging via improving mitochondrial biogenesis and inhibiting p53 signaling pathway in an AMPK-dependent manner
  746. Amelioration of premature aging in mtDNA mutator mouse by exercise: the interplay of oxidative stress, PGC-1α, p53, and DNA damage. A hypothesis
  747. Relevance of the p53–MDM2 axis to aging
  748. Multinucleated variant endothelial cells (MVECs) of human aorta: expression of tumor suppressor gene p53 and relationship to atherosclerosis and aging
  749. Control of cellular aging, tissue function, and cancer by p53 downstream of telomeres
  750. p53 and mouse aging models
  751. Modelling the p53/p66Shc aging pathway in the shortest living vertebrate Nothobranchius furzeri
  752. p53 isoforms regulate premature aging in human cells
  753. Altered S-nitrosylation of p53 is responsible for impaired antioxidant response in skeletal muscle during aging
  754. … expression of the p16 (INK4a)-Rb and p19 (Arf)-p53-p21 (Cip/Waf1) signaling pathways in the regulation of hematopoietic stem cell aging by ginsenoside Rg1
  755. p53 synthesis and phosphorylation in the aging diet-restricted rat following retinoic acid administration
  756. Delaying vascular aging with Chinese medicine: Implications from an overview of the p53 and miR-34s family
  757. Aging or tumor: The crosstalk between telomerase and p53
  758. The genetic architecture of aging: Sexual antagonistic plieotropy of p53 and foxo
  759. Transcription factor p53 and skin aging
  760. SirT3 and p53 deacetylation in aging and cancer
  761. Proliferative activity and expression of cyclin-dependent kinase inhibitor p21WAF1 and p53 protein in endothelial cells of human aorta during replicative aging in vitro
  762. p53, sex, and aging: lessons from the fruit fly
  763. Apoptosis is induced in aging SV40 T antigen-transformed human fibroblasts through p53-and p21CIP1/WAF1-independent pathways
  764. Do p53 stress responses impact organismal aging?
  765. Yifuning postpones ovarian aging through antioxidant mechanisms and suppression of the Rb/p53 signal transduction pathway
  766. Dual signaling mechanisms of estrogen: Phosphorylation of p53 at Ser15 in aging HMEC in the absence of estrogen receptor
  767. Effect of Angelica sinensis polysaccharide on expression of telomere, telomerase and p53 in mice aging hematopoietic stem cells
  768. Commitment of protein p53 and amyloid-beta peptide (Aβ) in aging of human cerebellum
  769. A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models
  770. Therapeutic applications of p53 isoforms in regenerative medicine, aging and cancer
  771. Elevated levels of oxidative DNA damage activate p53 and caspases in brain of ayu with aging
  772. Influence of Electro-acupuncture of Yongquan-point on the Expression of p53 and bcl-2 in the Aging Model Rat Induced by D-dalactose
  773. The Dysfunctional MDM2–p53 Axis in Adipocytes Contributes to Aging-Related Metabolic Complications by Induction of Lipodystrophy
  774. DNA methylation and specific sequience motifs: association with genetics instability in p53 in cancer, and other loci in degenerative disorders and aging
  775. Between Scylla and Charybdis: p53 links tumor suppression and aging
  776. The p53 Pathway, Cancer and Aging
  777. Nervous System Aging, Degeneration, and the p53 Family
  778. DNA damage, p53 gene expression and p53 protein level in the rat brain aging
  779. Aging and p53: getting it straight A commentary on a recent paper by Gentry and Venkatachalam
  780. Therapeutic applications of p53 isoforms in regenerative medicine, aging and cancer
  781. EXPRESSIONS OF p53/Rb CELLULAR TRANSDUCTION PATHWAY RELATED GENES AND PROTEINS IN AGING RATS TESTES [J]
  782. p53-suppressed oncogene TET1 prevents cellular aging in lung cancer
  783. Abstract B1: p53 isoforms, Δ133p53 and p53β, regulate aging-associated T lymphocyte senescence.
  784. Therapeutic applications of p53 isoforms in regenerative medicine, aging and cancer
  785. Involvement of p53 and Bcl-2 in sensory cell degeneration in aging rat cochleae
  786. Effect of Heshouwuyin on Rb/p53 Signal Transduction Pathway in Brain Tissue Cells of Aging Rat [J]
  787. Moxibustion on Carbonyl Stress and Expression of p19ARF and p53 mRNA in Livers of D-galactose-Induced Aging Rats
  788. Polysaccharides from Athyrium multidentatum (Doll.) Ching an Attenuated d-Galactose-Induced Mouse Aging via SIRT1-p53-p21 Pathway
  789. It’s all about balance: p53 and aging
  790. Effect of Heshouwuyin on Rb/p53 signal transduction pathway in aging rat testis tissue cells
  791. Insights into stem cells and aging provided by a p53 mutant mouse
  792. p53: Pro-aging or pro-longevity?
  793. Unraveling the link between the Mdm2-p53 axis and aging
  794. p53 mediated transcription of Omi/HtrA2 in aging myocardium
  795. The role of p53 signaling pathway in aging and cancer
  796. An investigation of p53 in skeletal muscle aging
  797. Gene dosage and aging in lung tumorigenesis in p53 (273H) transgenic mice
  798. Cyclin D1 and p53 and their expression in human Leydig cells during aging
  799. The impact of p53 codon 72 SNP upon aging and longevity in mouse models
  800. The Effects of Ultraviolet Radiation on Aging and p53 Expression in Human Skin
  801. Silent information regulator 1 gene induces aging of hepatocellular carcinoma cells via p53/p21 pathway
  802. Role of telomere dysfunction, DNA damage response and p53 mutations in tumorigenesis and aging
  803. New Targets of p53 Regulation: From Aging to Immune Response
  804. Inhibition of Cytosolic p53 Preserves Mitochondrial Integrity and Prevents Cardiac Aging
  805. Estrogen-induced phosphorylation of p53 at Ser15 in aging HMEC in the absence of estrogen receptor
  806. Interleukin 6 Knockout Inhibits Aging-Related Accumulation of p53 in the Mouse Myocardium
  807. p53 Promotes Cardiac Aging Through The Inhibition Of Parkin Mediated Mitochondrial Quality Control
  808. Abstract# 596: p53 deletion impairs clearance of chromosomal instable stem cells and accelerates epithelial aging in telomere dysfunctional mice
  809. l-Carnitine inhibits the senescence-associated secretory phenotype of aging adipose tissue by JNK/p53 pathway
  810. Aging and DNA-damage response activate a regulatory pathway involving miR-29 and p53
  811. Results-II. Haploinsufficiency of p53 Rescues Lifespan and Premature Aging-Associated Abnormalities in Sirt6-Deficient Mice
  812. Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53
  813. Abstract# 3478: Diminution of p53 during cellular senescence and organismal aging in normal human keratinocytes occurs at the post-transcriptional level
  814. P1842 Repetitive postprandial glucose/triglyceride spikes activate p53 in bone marrow progenitor cells and induce premature aging of bone marrow
  815. p53 in metabolism, aging and cancer.
  816. THE ROLE OF THE p53/P66SHC PATHWAY IN DEVELOPMENT AND AGING: DANIO RERIO (ZEBRAFISH) AND NOTHOBRANCHIUS AS MODEL ORGANISMS
  817. Expression of Aβ42, τ-Protein, p16, p53 in Buccal Epithelium: Prospects for Use in the Diagnostics of Alzheimer’s Disease and Rate of Aging
  818. Influence of aging on the interaction of the PI3K survival pathway and the p53-mediated apoptosis pathway in a rat model of myocardial ischemia-reperfusion
  819. C21 MECHANISMS THAT LINK AGING WITH LUNG DISEASE: THE CUTTING EDGE: Acrolein Induces p53-Mediated Cellular Senescence Accompanied By …
  820. … plays a pivotal role in collateral development under ischemia by suppressing aging-induced production of oxidative stress, expression of p53 and pro-apoptotic …
  821. Cytotoxicity effects of tert-butyl hydroperoxide-induced p53-mediated cell-cycle arrest, apoptosis and aging in rat aortic endotheial cells and aorta: inhibition by …
  822. … Plays a Pivotal Role in Collateral Development Under Ischemia by Suppressing Aging-Induced Production of Oxidative Stress, Expression of p53 and Pro-Apoptotic …
  823. Effects of electroacupuncture of yongquan acupoint on the expression of p53 and bcl-2 in aging model rats
  824. Is p53 a key to understanding the distinction of aging process between normal human and rodent cells?
  825. Aging, p53 and the ’24 gene mutant’: getting it right A reply to Vijg and Hasty
  826. Mitochondrial DNA damage contributes to premature aging through p53-dependent response mechanisms
  827. TheHarlequinMouse Model of Premature Aging Displays Increased p53 Signalling, Evidence of Vascular Dysfunction and Inflammation in the Retina and …
  828. REGc DEFICIENCY PROMOTES PREMATURE AGING VIA A CK1D-MDM2-p53 PATHWAY
  829. The p53 family in neurodegeneration, aging, and neural stem cell function
  830. Mechanism of p53-mediated aging and metabolism
  831. < SYMPOSIUM: Biology of Aging and Age-associated Skin Disorders> TELOMERASE ACTIVITY, p53 VS BCL-2 EXPRESSION AND APOPTOSIS IN HUMAN SKIN …
  832. … act as a negative regulator of aging in human gingival fibroblast via p53 and Sp1 transcription factors= 히스톤 탈아세틸화 효소인 HDAC1 과 HSIR2 는 p53 과 Sp1 전사 …
  833. Aging and Cancer: RHI, a bioreductive agent exerts its anti-cancer effect through both apoptosis and senescence accompanied with marked induction of …
  834. Aging and Cancer: p53 mediated apoptosis
  835. Aging & Cellular Senescence: A Molecular Mechanism of p53-induced Senescence
  836. Aging and Cancer: Statin induces p53-dependent ER stress and apoptosis
  837. Aging and Cancer: Simvastatin induces ER stress-mediated apoptosis through enhancing p53 and Bax translocation to mitochondria
  838. Aging and Cancer: Activation of p53 by an antitumor antibiotic, ascochlorin, distinct from DNA damaging agents
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