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P16ink4a

  1. … -apoptotic activity of whole extract and isolated indicaxanthin from Opuntia ficus-indica associated with re-activation of the onco-suppressor p16INK4a gene in human
  2. … -associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type-and insult-dependent manner and follow expression of p16INK4a
  3. … -mediated overexpression of p15INK4B inhibits human glioma cell growth, induces replicative senescence, and inhibits telomerase activity similarly to p16INK4a.
  4. … and immunoexpression of p16INK4a tumor suppressor gene in primary breast cancer tissue and their quantitative p16INK4a hypermethylation in plasma by …
  5. … cancer metastases to sentinel nodes: evaluation of its role as a marker for the presence of metastases in non-sentinel axillary nodes, and comparison to p16INK4a
  6. … E2F-1 blocks terminal differentiation and loss of leukemogenicity of M1 myeloblastic leukemia cells without abrogating induction of p15INK4B and p16INK4a
  7. … Effects of human insulin-like growth factor I gene modified myoblast transplantation on cardiomyocyte insulin-like growth factor I, p16INK4a and proliferating cell …
  8. … Increases the Cell Cycle Progression of Human Gingival Fibroblasts by Increasing Cyclin E and CDK 2 Expression and Decreasing p21WAF1/CIP1 and p16INK4a …
  9. … kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a
  10. … natural history of human papillomavirus infection in the head and neck squamous epithelium with particular respect to the significance of p16INK4a expression as a …
  11. … neurons of the embryonic and postnatal rat brain: Comparison with expression of the cell cycle regulators p21Waf1/Cip1, p27Kip1, p57Kip2, p16INK4a, cyclin G1, and …
  12. … of a novel human B‐cell line (OZ) with t (14; 18)(q32; q21) and aberrant p53 expression was associated with the homozygous deletions of p15INK4B and p16INK4a …
  13. … of human papillomavirus in a Spanish cohort of penile squamous cell carcinomas: Correlation with pathologic subtypes, p16INK4a expression, and prognosis
  14. … of limited adequacy and insufficient for grading as low or high grade: outcome, clinico-pathological correlates, and predictive role of p16INK4a and Ki67 biomarker …
  15. … of oncogenic KRAS mutations in squamous cell carcinomas of the anogenital tract and head and neck region independent of human papillomavirus and p16INK4a …
  16. … of penile carcinogenesis: HPV-induced penile cancers overexpress p16INK4a, HPV-negative cancers associated with dermatoses express p53, but lack p16INK4a …
  17. … of Penile Carcinogenesis: HPV-Induced Penile Cancers Overexpress p16INK4a, HPV-Negative Cancers Associated with Dermatoses Express p53, but Lack p16INK4a …
  18. … of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor beta growth inhibition in p16INK4a (-) human mammary epithelial cells …
  19. … of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor β growth inhibition in p16INK4a (−) human mammary epithelial cells
  20. … plus thioacetamide in Fischer 344 rats: Induction of gankyrin expression in liver fibrosis, pRB degradation in cirrhosis, and methylation of p16INK4a exon 1 in …
  21. … regulated by hepatocyte growth factor via ERK-dependent and ERK-independent signaling pathways, leading to increased expression of p16INK4a in hepatoma cells
  22. … S-transferase P1 and NADPH quinone oxidoreductase polymorphisms are associated with aberrant promoter methylation of p16INK4a and O6-methylguanine-DNA …
  23. … Senescence of Endothelial Progenitor Cells and Promotes Endothelial Repair by Suppressing the p38 MAP Kinase/p16INK4a Signaling Pathway. Diabetes 2010; 59 …
  24. … Senescence of Endothelial Progenitor Cells and Promotes Endothelial Repair by Suppressing the p38 MAP Kinase/p16INK4a Signaling Pathway. Diabetes 2010; 59 …
  25. … shows highly variable prevalence in esophageal squamous cell carcinoma and no significant correlation to p16INK4a overexpression: a systematic review
  26. … the mitogen-activated protein kinase pathway promotes DNA synthesis in primary hepatocytes from p21Cip-1/WAF1-null mice, but not in hepatocytes from p16INK4a …
  27. … Therapy in Ovarian Cancer: See The Biology Behind: ME Murphy, The Battle between Tumor Suppressors: Is Gene Therapy Using p16INK4a More Efficacious Than …
  28. … to several cancers but absence of linkage between dysplastic nevus syndrome and CDKN2A in a melanoma family with a mutation in the CDKN2A (p16INK4a) …
  29. … virus in oral squamous cell carcinoma and premalignat lesions, and the genetic and epigenetic aberrations of p14ARF and p16INK4a tumour suppressor genes …
  30. 1003 ORAL Crosstalk Between Homeobox Proteins and Polycomb Complexes in p16INK4a Regulation
  31. 1367 p16INK4a: No Correlation with Transcriptionally Active HPV16/18 or Outcomes in Oral Cavity Carcinoma
  32. 188 Point-of-care surrogate biomarkers for cervical cancer screening: feasibility of E7 oncoprotein and p16INK4a detection in cervical samples
  33. 5-Aza-2′-deoxycitydine induces demethylation and up-regulates transcription of p16INK4a gene in human gastric cancer cell lines.
  34. 5-Aza-2′-deoxycytidine leads to down-regulation of aberrant p16INK4a RNA transcripts and restores the functional retinoblastoma protein pathway in hepatocellular …
  35. 5-Aza-2′-deoxycytidine protects against emphysema in mice via suppressing p16INK4a expression in lung tissue
  36. 5‐Fluorouracil or gemcitabine combined with adenoviral‐mediated reintroduction of p16INK4a greatly enhanced cytotoxicity in Panc‐1 pancreatic adenocarcinoma …
  37. 9 Role of the p14ARF and p16INK4a Genes in Prostate Cancer
  38. A CDKN2A mutation in familial melanoma that abrogates binding of p16INK4a to CDK4 but not CDK6
  39. A cis-element within the ARF locus mediates repression of p16INK4a expression via long-range chromatin interactions
  40. A cocktail of p16INK4a and Ki-67, p16INK4a and minichromosome maintenance protein 2 as triage tests for human papillomavirus primary cervical cancer …
  41. A common variant of the p16INK4a genetic region is associated with physical function in older people
  42. A comparison analysis of anti-tumor efficacy of adenoviral gene replacement therapy (p14ARF and p16INK4a) in human mesothelioma cells.
  43. A comparison of the clinical utility of p16INK4a immunolocalization with the presence of human papillomavirus by hybrid capture 2 for the detection of cervical …
  44. A comprehensive evaluation of human papillomavirus positive status and p16INK4a overexpression as a prognostic biomarker in head and neck squamous …
  45. A Cyclin-Dependent Kinase Inhibitor, p16INK4a, in The Human Cancer Cells
  46. A High Prevalence of Functional Inactivation by Methylation Modification of p16INK4a/CDKN2/MTS1 Gene in Primary Urothelial Cancers
  47. A keratinocyte hypermotility/growth-arrest response involving laminin 5 and p16INK4a activated in wound healing and senescence
  48. A limited role for p16INK4a and p19Arf in the loss of hematopoietic stem cells during proliferative stress
  49. A microarray to analyze methylation patterns of p16INK4a gene 5′-CpG islands
  50. A new system for regulated functional gene expression for gene therapy applications: Nuclear delivery of a p16INK4a-estrogen receptor carboxy terminal fusion …
  51. A new system for regulated functional gene expression for gene therapy applications: nuclear delivery of a p16INK4a-estrogen receptor carboxy terminal fusion …
  52. A novel and sensitive electrogenerated chemiluminescence biosensor for detection of p16INK4a gene based on the functional paste-like nanofibers composites …
  53. A Novel Function for the Tumor Suppressor p16INK4a Induction of Anoikis via Upregulation of the α5β1 Fibronectin Receptor
  54. A novel p16INK4a mutation associated with esophageal squamous cell carcinoma in a high risk population
  55. A novel p16INK4a transcript
  56. A novel suicide gene therapy for the treatment of p16INK4a-overexpressing tumors
  57. A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma
  58. A panel of p16INK4a, MIB1 and p53 proteins can distinguish between the 2 pathways leading to vulvar squamous cell carcinoma
  59. A Pathway-focused GSEA Platform In AML That Interrogates Interaction of Flt3ITD and tMLL with Their Epigenetic Targets (p16INK4a, DAPK1, and RUNX3), While …
  60. A phase 1/2a study to test the safety and immunogenicity of a p16INK4a peptide vaccine in patients with advanced human papillomavirus‐associated cancers
  61. A piezoelectric immunosensor for the rapid detection of p16INK4a expression in liquid-based cervical cytology specimens
  62. A Prospective Study of Human Papillomavirus Changes Detected by Ki-67 and p16INK4a Immunohistochemistry in Women treated With Radiation for Cervical Cancer …
  63. A quantitative model for age-dependent expression of the p16INK4a tumor suppressor
  64. A search for CDKN2A/p16INK4a mutations in melanocytic nevi from patients with melanoma and spouse controls by use of laser-captured microdissection
  65. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy
  66. A simple stochastic model for the feedback circuit between p16INK4a and p53 mediated by p38MAPK: implications for senescence and apoptosis
  67. A Study on Significance of p16INK4a and Ki67 Proteins in Cervical Biopsies
  68. A subset of head and neck squamous cell carcinomas exhibits integration of HPV 16/18 DNA and overexpression of p16INK4a and p53 in the absence of mutations …
  69. A two-stage, p16INK4a-and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status
  70. ABCB5 and the regulation of p16INK4a by non-coding RNA
  71. Aberrant CpG island methylation of the p16INK4a and estrogen receptor genes in rat lung tumors induced by particulate carcinogens
  72. Aberrant expression of nNOS in pyramidal neurons in Alzheimer’s disease is highly co-localized with p21ras and p16INK4a
  73. Aberrant expression of p16INK4a in human cancers–a new biomarker?
  74. Aberrant expression of p53, p16INK4a and Ki‐67 as basic biomarker for malignant progression of oral leukoplakias
  75. Aberrant expression of pRb and p16INK4a, alone or in combination, indicates poor outcome after resection in patients with colorectal carcinoma
  76. Aberrant methylation of hMLH1 and p16INK4a in Tunisian patients with sporadic colorectal adenocarcinoma
  77. Aberrant methylation of p14ARF, p15INK4b and p16INK4a genes and location of the primary site in pulmonary squamous cell carcinoma
  78. Aberrant methylation of p16INK4a and deletion of p15INK4b are frequent events in human esophageal cancer in Linxian, China
  79. Aberrant methylation of p16INK4a in anatomic and gender-specific subtypes of sporadic colorectal cancer
  80. Aberrant methylation of p16INK4a is an early event in lung cancer and a potential biomarker for early diagnosis
  81. Aberrant methylation of the CDKN2a/p16INK4a gene promoter region in preinvasive bronchial lesions: A prospective study in high‐risk patients without invasive …
  82. Aberrant p16INK4a and DPC4/Smad4 expression in intraductal papillary mucinous tumours of the pancreas is associated with invasive ductal adenocarcinoma
  83. Aberrant p16INK4a methylation: Relation to viral related chronic liver disease and hepatocellular carcinoma
  84. Aberrant p16INK4a RNA transcripts expressed in hepatocellular carcinoma cell lines regulate pRb phosphorylation by binding with CDK4, resulting in delayed cell …
  85. Aberrant promoter methylation of p16INK4a and O6-methylguanine-DNA methyltransferase genes in workers at a Chinese uranium mine
  86. Aberrant promoter methylation of p16INK4a, RARB2 and SEMA3B in bronchial aspirates from patients with suspected lung cancer
  87. Aberrante Methylierung des p16INK4a-Promotors als Tumormarker für die molekularzytologische Diagnostik des Lungenkarzinoms an Bronchialaspiraten
  88. Aberrations of p16INK4a, p14ARF and p15INK4B genes in pediatric solid tumors
  89. Aberrations of the p14ARF and p16INK4a Genes in Renal Cell Carcinomas
  90. ABL oncogene amplification with p16INK4a gene deletion in precursor T‐cell acute lymphoblastic leukemia/lymphoma: Report of the first case
  91. Abnormal Expression of p16INK4a, Cyclin D1, Cyclin‐Dependent Kinase 4 and Retinoblastoma Protein in Gastric Carcinomas
  92. Abolition of cyclin-dependent kinase inhibitor p16INK4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized …
  93. Absence of p16INK4a and truncation of ARF tumor suppressors in chickens
  94. Abstract A12: Vicoryx: A phase I/IIa clinical trial using a p16INK4a derived peptide as vaccine in patients with advanced human papillomavirus-associated cancer
  95. Abstract A136: p16INK4a status of primary tumor modulates local immune response in vulvar squamous cell carcinoma
  96. Abstract B018: Restoration of p16INK4a expression in circulating tumor cells in patients with advanced solid tumors treated with deoxycytidine analogs and …
  97. Abstract LB-273: The tumor suppressor p16INK4a regulates extensive plasticity in rare somatic cells found in adult human tissue.
  98. Abstract P4-04-26: Down-regulation of p16INK4a inhibits miR-146b-5p and modulates IL-6 in breast stromal fibroblasts
  99. Abstract P6-08-34: p16INK4a expression and chemotherapy toxicity in women with early stage breast cancer
  100. Abstract# 4918: Loss of p16INK4a/ARF leads to up-regulation of IGFBP2 in human glioma and promotes formation of high-grade glioma in a mouse model
  101. Abstract# 5151: High frequency of ASC/TMS1, Rassf1A, and p16INK4a promoter methylation in succinate dehydrogenase complex B pheochromocytomas
  102. Abstract# 5340: The tumor suppressor p16INK4a protein positively regulates cyclin D1, E2F1 and p21WAF1 through negative control of AUF1
  103. Accelerated expression of senescence associated cell cycle inhibitor p16INK4a in kidneys with glomerular disease
  104. Accelerated somatic cell senescence and changes in p16INK4a expression after exogenous DNA transfection
  105. Acquired hypermethylation of the p16INK4a promoter in abdominal paraganglioma: relation to adverse tumor phenotype and predisposing mutation
  106. Acquisition of p16INK4a and p15INK4b gene abnormalities between initial diagnosis and relapse in children with acute lymphoblastic leukemia.
  107. Acquisition of p16INK4aandp15INK4BGene Abnormalities Between Initial Diagnosis and Relapse in Children With Acute Lymphoblastic Leukemia
  108. Activation of RB tumor suppressor protein and growth suppression of small cell lung carcinoma cells by reintroduction of p16INK4a gene.
  109. Active transcriptional repression by the Rb–E2F complex mediates G1 arrest triggered by p16INK4a, TGFβ, and contact inhibition
  110. Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment
  111. Acute telomere deprotection prevents ongoing BFB cycles and rampant instability in p16INK4a-deficient epithelial cells
  112. Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase/p16INK4a …
  113. Adjunct p16INK4a Immunohistochemistry Aids the Detection of High-Grade Squamous Intraepithelial Lesions in Endocervical Curettage Specimens
  114. Age-related accumulation of oxidative DNA damage and alterations in levels of p16INK4a/CDKN2a, p21WAF1/CIP1/SDI1 and p27KIP1 in human CD4+ T cell clones …
  115. Ageing as developmental decay: insights from p16INK4a
  116. Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16INK4a and Arf
  117. Aging increases p16INK4a expression in vascular smooth-muscle cells
  118. All‑trans retinoic acid enhances the effect of 5‑aza‑2’‑deoxycytidine on p16INK4a demethylation, and the two drugs synergistically activate retinoic acid …
  119. Allele-specific locus binding and genome editing by CRISPR at the p16INK4a locus
  120. Alterations in the p16INK4a/CDKN2A Tumor Suppressor Gene in Gastrinomas
  121. Alterations in the p53 pathway and p16INK4a expression predict overall survival in metastatic melanoma patients treated with dacarbazine
  122. Alterations of CDKN2 (MTS1/p16INK4a) gene in paraffin-embedded tumor tissues of human stomach, lung, cervix and liver cancers
  123. Alterations of cyclin-dependent kinase 4 inhibitor (p16INK4a/MTS1) gene structure and expression in acute lymphoblastic leukemias.
  124. Alterations of expression of Rb, p16INK4a and cyclin D1 in non‐small cell lung carcinoma and their clinical significance
  125. Alterations of p14ARF and p16INK4a genes in salivary gland carcinomas
  126. Alterations of p16INK4a and p14ARF in patients with severe oral epithelial dysplasia
  127. Alterations of p16INK4a and p15INK4B genes in gastric carcinomas
  128. Alterations of p16INK4a and p18INK4C, Human Papillomavirus infections and Expression of the Cell Cycle Associated Proteins in Cervical Carcinomas.
  129. Alterations of p16INK4a Gene in Korean Squamous Cell Carcinoma and Basal Cell carcinoma of the Skin
  130. Alterations of p16INK4a tumour suppressor gene in mucoepidermoid carcinoma of the salivary glands
  131. Alterations of pRb1-cyclin D1-cdk4/6-p16INK4a pathway in endometrial carcinogenesis
  132. Alterations of Rb, p16INK4a and cyclin D1 in the tumorigenesis of oral squamous cell carcinomas
  133. Alterations of the cell-cycle inhibitors p27KIP1 and p16INK4a are frequent in blastic plasmacytoid dendritic cell neoplasms
  134. Alterations of the p16INK4a gene in human ovarian cancers
  135. Alterations of the p16INK4a gene in resected nonsmall cell lung tumors and exfoliated cells within sputum
  136. Alterations of the p16INK4a/p14ARF pathway in clear cell sarcoma
  137. Alterations of the p16INK4a/Rb/cyclin-D1 pathway in vulvar carcinoma, vulvar intraepithelial neoplasia, and lichen sclerosus
  138. Alterations of the tumor suppressor genes CDKN2A (p16INK4a), p14ARF, CDKN2B (p15INK4b), and CDKN2C (p18INK4c) in atypical and anaplastic meningiomas
  139. Altered p16INK4a and Fhit expression in carcinogenesis and progression of human oral cancer
  140. AML at older age: age-related gene expression profiles reveal a paradoxical down-regulation of p16INK4a mRNA with prognostic significance
  141. An analysis on the combination expression of HPV L1 capsid protein and p16INK4a in cervical lesions
  142. An antibody to p16INK4a recognizes a modified form of galectin-3
  143. An association between nuclear morphology and immunohistochemical expression of p53 and p16INK4a in lung cancer cells
  144. An association of DNMT3b protein expression with p16INK4a promoter hypermethylation in non-smoking female lung cancer with human papillomavirus infection
  145. An evaluation of p16INK4a expression in cervical intraepithelial neoplasia specimens, including women with HIV-1
  146. An evaluation of the diagnostic and prognostic significance of p16INK4a/p21WAF1/Cip1 immunostaining in squamous intraepithelial lesions of the uterine cervix …
  147. An immunohistochemical study of p16INK4a expression in multistep thyroid tumourigenesis
  148. An internal ribosomal entry site in the 5′-untranslated region of p16INK4a mRNA provides a novel mechanism for the regulation of its translation
  149. An upward trend in DNA p16INK4a methylation pattern and high risk HPV infection according to the severity of the cervical lesion
  150. Anal intraepithelial neoplasia: correlation of grade with p16INK4a immunohistochemistry and HPV in situ hybridization
  151. Analysis of antibodies to p16INK4a tumor suppressor gene products in lung cancer patients.
  152. Analysis of cell cycle regulators: p16INK4a, pRb, and CDK4 in low-and high-grade meningiomas
  153. Analysis of cyclin dependent kinase inhibitors, p16INK4a and p15INK4b gene, in acute lymphoblastic leukemias
  154. Analysis of Immunohistochemical Expression of p16INK4a in Preneoplastic and Neoplastic Squamous cell lesions of Cervix
  155. Analysis of p16INK4a expression of oral squamous cell carcinomas in Taiwan: Prognostic correlation without relevance to betel quid consumption
  156. Analysis of p16INK4a gene promoter in male germ-cell tumors: identification of a new point mutation
  157. Analysis of P53, p16INK4a, PRB and cyclin D1 expression and human papillomavirus in primary ovarian serous carcinoma
  158. Analysis of p53/BAX/p16INK4a/CDKN2 in Esophageal Squamous Cell Carcinoma: High BAX and p16INK4a/CDKN2 Identifies Patients With Good Prognosis
  159. Analysis of pRb, p16INK4a proteins and proliferating antigens, PCNA, Ki-67 and MCM5 expression in aggressive fibromatosis (desmoid tumor)
  160. Analysis of the p16INK4a, p15INK4B and p18INK4C genes in multiple myeloma
  161. Antibody anti-p16INK4a in cervical cytology
  162. Antioxidants cinnamaldehyde and Galactomyces fermentation filtrate downregulate senescence marker CDKN2A/p16INK4a via NRF2 activation in keratinocytes
  163. Application of a time-resolved fluoroimmunoassay for detection of p16INK4a in cervix
  164. Are adjunctive markers useful in routine cervical cancer screening? Application of p16INK4a and HPV‐PCR on ThinPrep samples with histological follow‐up
  165. Assessing the use of p16INK4a promoter gene methylation in serum for detection of bladder cancer
  166. Assessment of Correlation Between p16INK4a Staining, Specific Subtype of Human Papillomavirus, and Progression of LSIL/CIN1 Lesions: First Comparative Study
  167. Assessment of the association between the frequency of micronucleus and p16INK4a/Ki-67 co-expression in patients with cervical intraepithelial lesions
  168. Association between folate metabolism-related gene polymorphisms and methylation of p16INK4a and hMLH1 genes in spontaneously aborted embryos with normal …
  169. Association between p16INK4a promoter methylation and HNSCC: a meta-analysis of 21 published studies
  170. Association between p16INK4a promoter methylation and non-small cell lung cancer: a meta-analysis
  171. Association between p16INK4a promoter methylation and ovarian cancer: a meta-analysis of 12 published studies
  172. Association of CDKN2A (p16INK4a) Polymorphisms and Promoter Methylation with Head and Neck Squamous Cell Carcinoma (HNSCC) in Puerto Rican Patients
  173. Association of CDKN2A/p16INK4a with human head and neck keratinocyte replicative senescence: relationship of dysfunction to immortality and neoplasia.
  174. Association of low p16INK4a and p15INK4b mRNAs expression with their CpG islands methylation with human hepatocellular carcinogenesis
  175. Association of p16INK4a hypermethylation with hepatitis B virus X protein expression in the early stage of HBV‐associated hepatocarcinogenesis
  176. Association of p16INK4a overexpression with improved outcomes in young patients with squamous cell cancers of the oral tongue
  177. Association of the expression of p53 and p16INK4a with the clinical and morphological characteristicsof patients with head and neck squamous cell cancer
  178. Associations of p16INK4a promoter hypermethylation with squamous intra-epithelial lesion, cervical cancer and their clinicopathological features: a meta …
  179. Atypical leiomyomas of the uterus with long-term follow-up after myomectomy with immunohistochemical analysis for p16INK4a, p53, Ki-67, estrogen receptors, and …
  180. Autophagy regulates the localization and degradation of p16INK4a
  181. Avaliação da expressão imunoistoquímica da proteína p16INK4a no adenocarcinoma de esôfago
  182. Azacitidine induces demethylation of p16INK4a and inhibits growth in adult T-cell leukemia/lymphoma
  183. Based immunosensor with signal amplification by enzyme-labeled anti-p16INK4a multifunctionalized gold nanoparticles for cervical cancer screening
  184. BAX and p16INK4a are independent positive prognostic markers for advanced tumour stage of nonsmall cell lung cancer
  185. Biallelic mutations in p16INK4a confer resistance to Ras-and Ets-induced senescence in human diploid fibroblasts
  186. Biologic and Biochemical Analyses of p16INK4a Mutations From Primary Tumors
  187. Biomarkers for cervical cancer screening: the role of p16INK4a to highlight transforming HPV infections
  188. Biomarkers in cervical screening: quantitative reverse transcriptase PCR analysis of p16INK4a expression
  189. Bmi-1 extends the replicative life span of normal human oral keratinocytes independently of p16INK4a
  190. Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16INK4a and p19Arf senescence …
  191. Bmi1 Loss in the Organ of Corti Results in p16INK4a Upregulation and Reduced Cell Proliferation of Otic Progenitors In Vitro
  192. Bmi1 promotes prostate tumorigenesis via inhibiting p16INK4a and p14ARF expression
  193. Bone marrow p16INK4a-deficiency does not modulate obesity, glucose homeostasis or atherosclerosis development
  194. Both p16INK4a and the p19Arf-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse
  195. Bowen’s disease on the sole: p16INK4a overexpression associated with human papillomavirus type 16
  196. c-JUN prevents methylation of p16INK4a (and Cdk6): the villain turned bodyguard
  197. C-terminal binding protein-2 promotes cell proliferation and migration in breast cancer via suppression of p16INK4a
  198. C‐terminal domain of p16INK4a is adequate in inducing cell cycle arrest, growth inhibition and CDK4/6 interaction similar to the full length protein in HT‐1080 …
  199. C282Y HFE polymorphism imparts temozolomide and 17-DMAG resistance via p16INK4a
  200. Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF
  201. Candidate tumor-suppressor genes MTS1 (p16INK4a) and MTS2 (p15INK4B) display frequent homozygous deletions in primary cells from T-but not from B-cell …
  202. CD47 activation-induced UHRF1 over-expression is associated with silencing of tumor suppressor gene p16INK4a in glioblastoma cells
  203. Cdk2-dependent phosphorylation and functional inactivation of the pRB-related p130 protein in pRB (−), p16INK4a (+) tumor cells
  204. CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms
  205. CDK4/6 and IGF1 receptor inhibitors synergize to suppress the growth of p16INK4a-deficient pancreatic cancers
  206. CDK6 and p16INK4a in lymphoid malignancies
  207. CDKN2 (MTS1/p16INK4a) Gene Alterations in Adult T-Cell Leukemia/Lymphoma
  208. CDKN2 (MTS1/p16INK4a) Gene Alterations in Hematological Malignancies
  209. CDKN2A (p14ARF/p16INK4a) and ATM promoter methylation in patients with impalpable breast lesions
  210. CDKN2A (p16INK4a) and CDK4 mutation analysis in 131 Australian melanoma probands: Effect of family history and multiple primary melanomas
  211. CDKN2A (p16INK4a) somatic and germline mutations
  212. Cdkn2a encodes functional variation of p16INK4a but not p14ARF, which confers selection in mouse lung tumorigenesis
  213. Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16INK4a and p19ARF, is a candidate for the plasmacytoma susceptibility locus, Pctr1
  214. CDKN2A/p16INK4a 5′ UTR variants in melanoma predisposition: Lost in translation, somewhere
  215. CDKN2A/p16INK4a expression is associated with vascular progeria in chronic kidney disease
  216. CDKN2a/p16INK4a mutations and lack of p19ARF involvement in familial melanoma kindreds
  217. Cdkn2a/p16INK4a regulates fasting-induced hepatic gluconeogenesis through the PKA-CREB-PGC1α pathway
  218. CDKN2A/p16INK4a variants association with breast cancer and their in-silico analysis
  219. Cell cycle arrest and cytochrome c-mediated apoptotic induction by MCS-5A is associated with up-regulation of p16INK4a in HL-60 cells
  220. Cell cycle regulators p16INK4a in metaplasia, dysplasia, and adenocarcinoma of Barrett’s esophagus.
  221. Cell protein p16INK4a hyperexpression in epithelial malignancies induced by human papillomaviruses
  222. Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence
  223. Cellular senescence in biliary pathology. Special emphasis on expression of a polycomb group protein EZH2 and a senescent marker p16INK4a in bile ductular …
  224. Cellular senescence markers p16INK4a and p21CIP1/WAF are predictors of Hodgkin lymphoma outcome
  225. Cellular senescence mediated by p16INK4a-coupled miRNA pathways
  226. Cellular senescence protein p16INK4a of cancer-associated fibroblasts (CAFs) as a prognostic indicator for cholangiocarcinoma patients
  227. Centrosome aberrations in human mammary epithelial cells driven by cooperative interactions between p16INK4a deficiency and telomere-dependent …
  228. Cervical biopsy: Is the histological diagnosis reliable and reproducible? Utility of p16INK4a in its achievement
  229. Changes in p16INK4a (p16) expression, a biomarker of aging, in peripheral blood T-cells (PBTC) in patients receiving anthracycline (A) vs non-anthracycline (NoA) …
  230. Characterization of coordinated immediate responses by p16INK4a and p53 pathways in UVB-irradiated human skin cells
  231. Characterization of regulatory elements on the promoter region of p16INK4a that contribute to overexpression of p16 in senescent fibroblasts
  232. Characterization of squamous cell cancers of the vulvar anterior fourchette by human papillomavirus, p16INK4a, and p53
  233. Chemiluminescent Quantitative Immunohistochemical p16INK4a Localization as a Marker for Cervical Intraepithelial Neoplasias
  234. Chemotherapy and stem cell transplantation increase p16INK4a expression, a biomarker of T-cell aging
  235. Chemotherapy and Stem Cell Transplantation Increase p16INK4a Expression, a Biomarker of T-cell Aging
  236. Chlamydia trachomatis and human papillomavirus coinfection: association with p16INK4a and Ki67 expression in biopsies of patients with pre-neoplastic and …
  237. Chronic hepatitis B virus infection and the methylation status of p16INK4a promoter
  238. Chronic Oral Exposure to Inorganic Arsenate Interferes with Methylation Status of p16INK4a and RASSF1A and Induces Lung Cancer in A/J Mice
  239. Chronic stress exposure and daily stress appraisals relate to biological aging marker p16INK4a
  240. CHRONIC STRESS EXPOSURE AND DAILY STRESS APPRAISALS RELATE TO BIOLOGICAL AGING MARKER p16INK4a IN MID-LIFE PARENTS
  241. Ciliated muconodular papillary tumor of the lung harboring BRAF V600E mutation and p16INK4a overexpression without proliferative activity may represent …
  242. Classical and non-classical HLA molecules and p16INK4a expression in precursors lesions and invasive cervical cancer
  243. Cleaved high molecular weight kininogen induces endothelial progenitor cell senescence in a ROS–p38MAPK-p16INK4a signaling pathway and inhibits their …
  244. Clinical role of hWAPL in histologic diagnosis of cervical cancer and cervical intraepithelial neoplasia: Correlation with p16INK4a expression and HPV testing
  245. Clinical Role of p16INK4a Expression in Liquid-Based Cervical Cytology: Correlation With HPV Testing and Histologic Diagnosis
  246. Clinical significance of p16INK4a and p14ARF promoter methylation in renal cell carcinoma: a meta-analysis
  247. Clinical Significance of p16INK4a and p53 Overexpression in Endocrine Tumors of the Gastrointestinal Tract
  248. Clinical significance of p16INK4a and retinoblastoma proteins in non-small-cell lung carcinoma
  249. Clinical significance of p53 and p16INK4a status in a contemporary North American Penile Carcinoma Cohort
  250. Clinicopathologic significance of p16INK4a, Ki-67 and HPV DNA16/18 expression in squamous cell lesions of postmenopausal women cervix.
  251. Clinicopathological comparison of adenocarcinoma of cervix and endometrium using cell cycle markers: p16INK4a, P21waf1, and p27Kip1 on 132 cancers
  252. Clinicopathological parameters of cervical cancer based on the expression of p16INK4a proteins
  253. Cloning and characterization of murine p16INK4a and p15INK4b genes.
  254. Co-expression of p16INK4a and laminin 5 by keratinocytes: a wound-healing response coupling hypermotility with growth arrest that goes awry during …
  255. Co-expression of p16INK4a and laminin 5 γ2 by microinvasive and superficial squamous cell carcinomas in vivo and by migrating wound and senescent keratinocytes …
  256. Co-regulation of p16INK4a and migratory genes in culture conditions that lead to premature senescence in human keratinocytes
  257. Coexpression of p16INK4a and laminin55 gamma 2 in keratinocytes: a normal wound-healing response that goes awry during neoplastic progression
  258. Coincidental alterations of p16INK4a/CDKN2 and other genes in human lung cancer cell lines.
  259. Collateral damage: Molecular aging and p16INK4a senescence protein in testicular cancer survivors treated with chemotherapy.
  260. Collective inhibition of pRB family proteins by phosphorylation in cells with p16INK4a loss or cyclin E overexpression
  261. Combination of p16INK4a‐Ki67 immunocytology and HPV polymerase chain reaction for the noninvasive analysis of HPV involvement in head and neck cancer
  262. Combination of p16INK4a/Ki67 immunocytology and hpv polymerase chain reaction for the noninvasive analysis of HPV involvement in head and neck cancer
  263. Combination radiation and adenovirus-mediated p16INK4a gene therapy in a murine model for head and neck cancer
  264. Combined analysis of HPV DNA and p16INK4a expression to predict prognosis in ASCUS and LSIL pap smears
  265. Combined detection of p16INK4a and IMP3 increase the concordance rate between cervical cytologic and histologic diagnosis
  266. Combined Expression of p16INK4a and p27Kip1, But Not p21WAF1, Differentiates Endocervical from Endometrial Adenocarcinoma
  267. Combined p16INK4a and human papillomavirus testing improves the prediction of cervical intraepithelial neoplasia (CIN II-III) in Thai patients with low-grade …
  268. Combined serial section‐based 3D reconstruction of cervical carcinoma invasion using H&E/p16INK4a/CD3 alternate staining
  269. Combining routine morphology, p16INK4a immunohistochemistry, and in situ hybridization for the detection of human papillomavirus infection in penile carcinomas: A …
  270. Comments on Bu et al.“p16INK4a overexpression and survival in osteosarcoma patients: a meta analysis”
  271. Comments on the article of Bu, et al entitled “p16INK4a overexpression and survival in osteosarcoma patients: a meta analysis”
  272. Comparative detection and quantitation of human CDK inhibitor mRNA expression of p15INK4B, p16INK4a, p16β, p18INK4C, p19INK4D, p21WAF1, p27KIP1 and …
  273. Comparison Between p16INK4a Immunohistochemistry and Human Papillomavirus Polymerase Chain Reaction Assay in Oral Papillary Squamous Cell Carcinoma
  274. Comparison of p16INK4a and Hybrid Capture® 2 human papillomavirus testing as adjunctive tests in liquid‐based gynecologic SurePath™ preparations
  275. Comparison of p16INK4a and ProEx™ C immunostaining on cervical ThinPrep® cytology and biopsy specimens
  276. Comparison of p16INK4a expression with p53 alterations in head and neck cancer by tissue microarray analysis
  277. Comparison of p16INK4a immunocytochemistry with the HPV polymerase chain reaction in predicting high grade cervical squamous intraepithelial lesions
  278. Comparison of p16INK4a immunostaining in benign and malignant HPV-related lesion
  279. Comparison of ProEx C with p16INK4a and Ki‐67 immunohistochemical staining of cell blocks prepared from residual liquid‐based cervicovaginal material: A pilot …
  280. Complex patterns of chromosome 9 alterations including the p16INK4a locus in Wilms tumours
  281. Comprehensive analysis of CDKN2A (p16INK4a/p14ARF) and CDKN2B genes in 53 melanoma index cases considered to be at heightened risk of melanoma
  282. Compromising the constitutive p16INK4a expression sensitizes human neuroblastoma cells to Hsp90 inhibition and promotes premature senescence
  283. Computational assessment of somatic and germline mutations of p16INK4a: Structural insights and implications in disease
  284. Concentrations of pro-inflammatory cytokines are not associated with senescence marker p16INK4a or predictive of intracellular emtricitabine/tenofovir …
  285. Concerted promoter hypermethylation of hMLH1, p16INK4a, and E‐cadherin in gastric carcinomas with microsatellite instability
  286. Concomitant expression of p16INK4a and p14ARF in primary breast cancer and analysis of inactivation mechanisms
  287. Concurrence of replicative senescence and elevated expression of p16INK4a with subculture-induced but not calcium-induced differentiation in normal human oral …
  288. Conjunctive p16INK4a Testing Significantly Increases Accuracy in Diagnosing High-Grade Cervical Intraepithelial Neoplasia
  289. Conspirators in a capital crime: co-deletion of p18INK4c and p16INK4a/p14ARF/p15INK4b in glioblastoma multiforme
  290. Contrasting behavior of the p18INK4c and p16INK4a tumor suppressors in both replicative and oncogene-induced senescence
  291. Contribution of p16INK4a to replicative senescence of human fibroblasts
  292. Controlled induction and targeted elimination of p16INK4a-expressing chondrocytes in cartilage explant culture
  293. Conventional cytology, visual tests and evaluation of p16INK4a as a biomarker in cervical intraepithelial neoplasia
  294. COOH-terminal binding protein regulates expression of the p16INK4a tumor suppressor and senescence in primary human cells
  295. Correction: Induction of p16INK4a Is the Major Barrier to Proliferation when Epstein-Barr Virus (EBV) Transforms Primary B Cells into Lymphoblastoid Cell Lines
  296. Correction: p16INK4a Expression and Immunologic Aging in Chronic HIV Infection
  297. Correlation among 16 biological factors [p53, p21waf1, MIB‑1 (Ki‑67), p16INK4a, cyclin D1, E‑cadherin, Bcl‑2, TNF‑α, NF‑κB, TGF‑β, MMP‑7, COX‑2, EGFR …
  298. Correlation between expression of DNMT3B6s and promoter methylation of tumor suppressor genes p16INK4a and RASSF1A in non-small cell lung cancer
  299. Correlation between p14ARF/p16INK4a expression and HPV infection in uterine cervical cancer
  300. Correlation between p21waf1 and p16INK4a expression in hepatocellular carcinoma
  301. Correlation of abnormal RB, p16INK4a, and p53 expression with 3p loss of heterozygosity, other genetic abnormalities, and clinical features in 103 primary non-small …
  302. Correlation of p16INK4a immunoexpression and human papillomavirus (HPV) detected by in-situ hybridization in cervical squamous neoplasia
  303. Correlation of p16INK4a overexpression with human papillomavirus infection in cervical adenocarcinomas
  304. Correlation of PD-L1 expression with p16INK4a expression in nonoropharyngeal head and neck squamous cell carcinoma.
  305. Correlations between p16INK4a expression and HPV infection to cervical intraepithelial neoplasia and cervical squamous cell carcinoma
  306. Correlative immunohistochemistry and molecular genetic study of the inactivation of the p16INK4a genes in astrocytomas.
  307. Creg1 And Its Enhancement Of p16INK4a-Induced Senescence
  308. CREG1 enhances p16INK4a-induced cellular senescence
  309. CSN6 promotes tumorigenesis of gastric cancer by ubiquitin-independent proteasomal degradation of p16INK4a
  310. CtBP1 is expressed in melanoma and represses the transcription of p16INK4a and Brca1
  311. CtBP2 contributes to malignant development of human esophageal squamous cell carcinoma by regulation of p16INK4a
  312. Culturing on Wharton’s jelly extract delays mesenchymal stem cell senescence through p53 and p16INK4a/pRb pathways
  313. Cumulation of TP53 mutations and p16INK4a/p15INK4B homozygous deletions in human papilloma virus type 16 positive scrotal cancer
  314. Cyclin D1 and p16INK4a are preferentially expressed in immature and mature myeloma cells, respectively
  315. Cyclin D1 and p16INK4a expression predict reduced survival in carcinoma of the anterior tongue
  316. Cyclin E and c‐Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins
  317. Cyclin-dependent kinase inhibitor p16INK4a and telomerase may co-modulate endothelial progenitor cells senescence
  318. Cyclin-dependent kinase inhibitor p16INK4a inhibits phosphorylation of RNA polymerase II by general transcription factor TFIIH
  319. Cysteine oxidation triggers amyloid fibril formation of the tumor suppressor p16INK4a
  320. Cytotoxicity of 5-Aza-2′-deoxycytidine against gastric cancer involves DNA damage in an ATM-P53 dependent signaling pathway and demethylation of p16INK4a
  321. DDB1-CUL4 and MLL1 mediate oncogene-induced p16INK4a activation
  322. De novo methylation of the p16INK4a gene in early preneoplastic liver and tumors induced by folate/methyl deficiency in rats
  323. Decreasing expression of the G1-phase inhibitors, p21Cip1 and p16INK4a, promotes division of corneal endothelial cells from older donors
  324. Decreasing Expression of the G1-Phase Inhibitors, p21Cip1 and p16INK4a, Promotes Division of Corneal Endothelial Cells From Older Donors
  325. Definition of three minimal deleted regions by comprehensive allelotyping and mutational screening of FHIT,p16INK4a, and p19ARF genes in nasopharyngeal …
  326. Deletion and altered regulation of p16INK4a and p15INK4b in undifferentiated mouse skin tumors
  327. Deletion and differential expression of p16INK4a in mouse lung tumors.
  328. Deletion in p16INK4a and loss of p16 expression in human skin primary and metastatic melanoma cells
  329. Deletion of one copy of the p16INK4a tumor suppressor gene is implicated as a predisposing factor in pediatric leukemia
  330. Deletion of p16INK4a/CDKN2 and p15INK4B in human somatic cell hybrids and hybrid-derived tumors
  331. Deletion of the Ink4-locus (the p16INK4a, p14ARF and p15ink4b genes) predicts relapse in children with ALL treated according to the Nordic protocols …
  332. Deletion of the p16INK4a Gene in ex Vivo Acute Adult T Cell Lymphoma/Leukemia Cells and Methylation of the p16INK4a Promoter in HTLV Type I-Infected T Cell …
  333. Deletion of the p16INK4a tumor suppressor and expression of the androgen receptor induce sarcomatoid carcinomas with signet ring cells in the mouse …
  334. Deletions and Loss of Expression of p16INK4a and P21Waf1 Genes Are Associated With Aggressive Variants of Mantle Cell Lymphomas
  335. Deletions of the cyclin-dependent kinase inhibitor genes p16INK4a and p15INK4B in non-Hodgkin’s lymphomas
  336. Depletion of the cdk inhibitor p16INK4a differentially affects proliferation of established cervical carcinoma cells
  337. Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4a-mediated growth suppression.
  338. Deregulated expression of p16INK4a and p53 pathway members in benign and malignant myoepithelial tumours of the salivary glands
  339. Deregulation of the tumour suppressor genes p14ARF, p15INK4b, p16INK4a and p53 in basal cell carcinoma
  340. Descriptive study of Expression of p16INK4a in Different Types of Lesions in Uterine Cervix
  341. Design and characterization of a hyperstable p16INK4a that restores Cdk4 binding activity when combined with oncogenic mutations
  342. Detecting a Tumor Suppressor Protein (p16INK4a) in Zebrafish (Danio rerio)
  343. Detecting homozygous deletions in the CDKN2A (p16INK4a)/ARF (p14ARF) gene in urinary bladder cancer using real-time quantitative PCR
  344. Detection and pathological value of papillomavirus DNA and p16INK4a and p53 protein expression in cervical intraepithelial neoplasia
  345. Detection of Aberrant p16INK4a Methylation in Sera of Patients With HCV Related Liver Diseases: An Egyptian Study
  346. Detection of aberrant p16INK4a methylation in sera of patients with HCV-related liver diseases: An Egyptian study
  347. Detection of aberrant p16INK4a methylation in sera of patients with liver cirrhosis and hepatocellular carcinoma
  348. Detection of circulating methylated p16INK4a in the serum of Puerto Rican HNSCC patients.
  349. Detection of HPV16 infection and p16INK4a expression in concurrent cancers from esophagus and gastric cardia in same high-incidence area patient.
  350. Detection of human papilloma virus (HPV) in liquid-based cervical samples. Correlation with protein p16INK4a expression
  351. Detection of human papilloma virus subtypes 16 and p16INK4a in invasive squamous cell carcinoma of the fallopian tube and concomitant squamous cell carcinoma …
  352. Detection of Human papillomavirus and cellular regulators p16INK4a, p53, and NF-kappaB in penile cancer cases in Kenya.
  353. Detection of methylation in the CpG islands of the p16INK4a, RASSF 1A and methylguanine methyltransferase gene promoters in pancreatic adenocarcinoma
  354. Detection of p16INK4a in Oropharyngeal and Upper Respiratory tract Squamous cell Carcinoma
  355. Detection p16INK4a protein in cervical tissues with time-resolved fluoroimmunoassay
  356. Developing nanobodies to stabilise the tumour suppressor protein p16INK4a
  357. Development of Novel p16INK4a Mimetics as Anticancer Therapy
  358. Diagnostic accuracy of p16INK4a immunohistochemistry in oropharyngeal squamous cell carcinomas: A systematic review and meta‐analysis
  359. Diagnostic Role of RASSF1A and p16INK4a Promoter Gene Hypermethylation in Serum DNA of Lung Cancer Patients: Clinicopathological Significance.
  360. Diagnostic utility of p16INK4a: a reappraisal of its use in cervical biopsies
  361. Diagnostic value of p16INK4a in squamous intraepithelial lesion in gynecologic cytology
  362. Diagnostic value of p16INK4a, Ki‐67, and human papillomavirus L1 capsid protein immunochemical staining on cell blocks from residual liquid‐based gynecologic …
  363. Die prognostische Bedeutung von nukleärer und zytoplasmatischer p16INK4a-Expression sowie der Expression von E2F1 in gastrointestinalen Stromatumoren (GIST …
  364. Dietary folate is associated with p16INK4a methylation in head and neck squamous cell carcinoma
  365. Different expression of p16INK4a and p14ARF in cervical and lung cancers
  366. Different incidence and pattern of p15INK4b and p16INK4a promoter region hypermethylation in Hodgkin’s and CD30-Positive non-Hodgkin’s lymphomas
  367. Different p16INK4a and p14ARF Expression Patterns in Acute Myeloid Leukaemia and Normal Blood Leukocytes
  368. Different patterns of p16INK4a and p53 protein expressions in intraductal papillary-mucinous neoplasms and pancreatic intraepithelial neoplasia
  369. Differential effects of p19Arf and p16INK4a loss on senescence of murine bone marrow-derived preB cells and macrophages
  370. Differential Expression of p16INK4a in Azoxymethane‐Induced Mouse Colon Tumorigenesis
  371. Differential Frequencies of p16INK4a Promoter Hypermethylation, p53 Mutation, and K-ras Mutation in Exfoliative Material Mark the Development of Lung Cancer in …
  372. Differential retinoblastoma and p16INK4a protein expression in neuroendocrine tumors of the lung
  373. Differential roles of p16INK4a and p14ARF genes in prognosis of oral carcinoma
  374. Dioxin-induced immortalization of normal human keratinocytes and silencing of p53 and p16INK4a
  375. Direct down-regulation of eEF1A2 by Tumor suppressor p16INK4a inhibits cancer cell growth
  376. Direct evidence from siRNA-directed “knock down” that p16INK4a is required for human fibroblast senescence and for limiting ras-induced epithelial cell proliferation
  377. Disfigurement of p16INK4a gene expression in development of cervical cancer and study of the mechanism
  378. Disfigurement of p16INK4a gene expression in development of ovarian cancer and the mechanism
  379. Disfigurement of p16INK4a gene expression in the development of endometrial diseases
  380. Disruption of the Multiple Tumor Suppressor Gene MTS1/p16INK4a/CDKN2 by Illegitimate V(D)J Recombinase Activity in T-Cell Acute Lymphoblastic Leukemias
  381. Disruptive cell cycle regulation involving epigenetic downregulation of Cdkn2a (p16INK4a) in early-stage liver tumor-promotion facilitating liver cell regeneration in rats
  382. Dissecting the contribution of p16INK4a and the Rb family to the Ras transformed phenotype
  383. Dissecting the oncogenic consequences of p19Arf/p53-and p16INK4a/pRB-pathway disruption
  384. Dissection of CDK4-Binding and Transactivation Activities of p34SEI-1 and Comparison between Functions of p34SEI-1 and p16INK4a
  385. Distinct patterns of inactivation of p15INK4B and p16INK4a characterize the major types of hematological malignancies
  386. Distinct promoter hypermethylation of p16INK4a, CDH1, and RAR‐beta in intestinal, diffuse–adherent, and diffuse–scattered type gastric carcinomas
  387. Distinct susceptibility of induction of methylation of p16INK4a and p19arf CpG islands by X-radiation and chemical carcinogen in mice
  388. Distinctive association of p16INK4a overexpression with penile intraepithelial neoplasia depicting warty and/or basaloid features: a study of 141 cases evaluating a …
  389. Distinctive crypt shape in a sessile serrated adenoma/polyp: Distribution of Ki67-, p16INK4a-, WNT5A-positive cells and intraepithelial lymphocytes
  390. DNA copy number aberrations and disruption of the p16INK4a/Rb pathway in radiation-induced and spontaneous rat mammary carcinomas
  391. DNA methylation and expression of p16INK4a gene in pulmonary adenocarcinoma and anthracosis in background lung
  392. DNA methylation status of hMLH1, p16INK4a, and CDH1 is not associated with mRNA expression levels of DNA methyltransferase and DNA demethylase in gastric …
  393. Does p16INK4a expression increase with the number of cell doublings in normal and malignant lymphocytes?
  394. Double positivity for HPV-DNA/p16INK4a is the biomarker with strongest diagnostic accuracy and prognostic value for human papillomavirus related oropharyngeal …
  395. Down-regulation of p16INK4a by hYSK1 promotes cancer cell migration under hypoxic conditions
  396. Downregulation and aberrant promoter methylation of p16INK4a: A possible novel heritable susceptibility marker to retinoblastoma
  397. Downregulation of p16INK4a inhibits cell proliferation and induces G1 cell cycle arrest in cervical cancer cells
  398. Dual stain immunohistochemical localization of p16INK4a and ki-67: a synergistic approach to identify clinically significant cervical mucosal lesions
  399. Duration but not intensity of alcohol and tobacco exposure predicts p16INK4a homozygous deletion in head and neck squamous cell carcinoma
  400. Dynamic expression of p16INK4a gene in lung fibroblasts of neonatal rats with chronic lung disease.
  401. Dysregulation of the Bmi‐1/p16INK4a pathway provokes an aging‐associated decline of submandibular gland function
  402. E47 Governs the MYC-CDKN1B/p27KIP1-RB Network to Growth Arrest PDA Cells Independent of CDKN2A/p16INK4a and Wild-Type p53
  403. Early deregulation of the p16INK4a-cyclin D1/cyclin-dependent kinase 4-retinoblastoma pathway in cell proliferation-driven esophageal tumorigenesis in zinc-deficient …
  404. Early loss of proliferative potential of human peritoneal mesothelial cells in culture: the role of p16INK4a-mediated premature senescence
  405. Effect of 2LMISEN® on Long-Term Hippocampal Neurons Culture as a Screening Senescent Cells Model: p16INK4a and Caspase 3 Quantification
  406. Effect of 5-aza-2′-deoxycytidine on p16INK4a, p14ARF, p15INK4b Genes Expression, Cell Viability, and Apoptosis in PLC/PRF5 and MIA Paca-2 Cell Lines
  407. Effect of exogenous p16INK4a and hRb1 genes on cell cycle regulation of osteosarcoma cell
  408. Effect of human papillomavirus on cell cycle-related proteins p16INK4a, p21waf1/cip1, p53 and cyclin D1 in sinonasal inverted papilloma and laryngeal carcinoma. An …
  409. Effect of iodine intake on p14ARF and p16INK4a expression in thyroid papillary carcinoma in rats
  410. Effect of metabolizable peptide p16INK4a on short-lived human tumor cultures
  411. Effect of p16INK4a on chemosensitivity in nasopharyngeal carcinoma cells.
  412. Effect of phosphorylation and methylation on the function of the p16INK4a protein in non-small cell lung cancer A549 cells
  413. Effect of QS Alex 755 nm Laser on the Expression of p16INK4a on the Melanoma Cell Lines
  414. Effects of CDKN2A (p16INK4a/p14ARF) over-expression on proliferation and migration of human melanoma A375 Cells
  415. Effects of exogenous p16INK4a on growth of cells with various status of cell-cycle regulators.
  416. Effects of simian virus 40 T-antigens on normal human mammary epithelial cells reveal evidence for spontaneous alterations in addition to loss of p16INK4a …
  417. Efficacy evaluation of a test CINtec® p16INK4a in screening for cervical HPV infection
  418. Efficient immortalization of primary human cells by p16INK4a‐specific short hairpin RNA or Bmi‐1, combined with introduction of hTERT
  419. EGFR, p16INK4a and E-cadherin immuno-histochemistry and EGFR point mutations analyses in invasive cervical cancer specimens from Moroccan women.
  420. EGFR, p16INK4a and E-cadherin immuno-histochemistry and EGFR point mutations analyses in invasive cervical cancer specimens from Moroccan women.
  421. Electron microscopy evidence that cytoplasmic localization of the p16INK4a “nuclear” cyclin-dependent kinase inhibitor (CKI) in tumor cells is specific and not an …
  422. Elevated p16INK4a expression in human labial salivary glands as a potential correlate of cognitive aging in late midlife
  423. Endothelial toll‐like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a
  424. Enhanced p16INK4a Expression In Cervical Cancer Among HPV Infected Women
  425. Enzyme-linked Immunosorbent Assay-based Detection of Biomarker Protein p16INK4a in Lysed Cervical Samples
  426. Enzyme‐linked immunosorbent assay for p16INK4a– a new triage test for the detection of cervical intraepithelial neoplasia?
  427. EP294 Comparison of triage management between p16INK4a/Ki67 dual staining and HR-HP test in patients with cervical cytology ASC-US and LSIL
  428. Epigallocatechin-3-gallate and trichostatin A synergistically inhibit human lymphoma cell proliferation through epigenetic modification of p16INK4a
  429. Epigenetic alteration of p16INK4a gene in dedifferentiation of liposarcoma
  430. Epigenetic alterations of p15INK4B and p16INK4a genes in pediatric primary myelodysplastic syndrome
  431. Epigenetic changes in the CDKN2A locus are associated with differential expression of p16INK4a and P14ARF in HPV‐positive oropharyngeal squamous cell …
  432. Epigenetic inactivation of 14-3-3 σ in oral carcinoma: association with p16INK4a silencing and human papillomavirus negativity
  433. Epigenetic regulation of p14ARF and p16INK4a expression in cutaneous and uveal melanoma
  434. Epigenetic regulation of p16INK4a and Arf by JDP2 in cellular senescence
  435. Epigenetic regulation of p16INK4a-MMP-1 axis in OA-associated senescence-like phenotype and hypertrophy of chondrocytes
  436. Epigenetic repression of p16INK4a by Latent Epstein-Barr Virus requires the interaction of EBNA3A and EBNA3C with CtBP
  437. Epigenetic silencing of the p16INK4a tumor suppressor is associated with loss of CTCF binding and a chromatin boundary
  438. Epithelial Cells Derived from Human Embryonic Stem Cells Display p16INK4a Senescence, Hypermotility, and Differentiation Properties Shared by Many P63+ …
  439. Epstein-Barr virus and p16INK4a methylation in squamous cell carcinoma and precancerous lesions of the cervix uteri
  440. Epstein-Barr virus infection correlates with the expression of COX-2, p16INK4a and p53 in classic Hodgkin lymphoma
  441. Epstein-Barr virus inhibits p16INK4a expression in human fetal nasopharyngeal epithelial cells escaping from the replicative senenscence
  442. Epstein-Barr virus LMP1 blocks p16INK4a–RB pathway by promoting nuclear export of E2F4/5
  443. Epstein-Barr virus nuclear antigens 3C and 3A maintain lymphoblastoid cell growth by repressing p16INK4a and p14ARF expression
  444. Erratum to: RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4a, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell …
  445. Estimating clinical outcome of HPV induced cervical lesions by combination of capsid protein L1 and p16INK4a protein detection
  446. Estimation of Prognoses for Cervical Intraepithelial Neoplasia 2 by p16INK4a Immunoexpression and High-Risk HPV In Situ Hybridization Signal Types
  447. ETS-dependent p16INK4a and p21waf1/cip1 gene expression upon endothelin-1 stimulation in malignant versus and non-malignant proximal tubule cells
  448. Evaluation of a new p16INK4a ELISA test and a high‐risk HPV DNA test for cervical cancer screening: Results from proof‐of‐concept study
  449. Evaluation of a nuclear score for p16INK4a‐stained cervical squamous cells in liquid‐based cytology samples
  450. Evaluation of an ELISA for p16INK4a as a screening test for cervical cancer
  451. Evaluation of an Enzyme-linked Immunosorbent Assay-based p16INK4a Detection Assay for the Identification of High-grade Cervical Intraepithelial Neoplasia in …
  452. Evaluation of biomarkers p16INK4a/ki-67 in cervical cytology for diagnosis of cervical intraepithelial neoplasia
  453. Evaluation of cervical cone biopsies for coexpression of p16INK4a and Ki‐67 in epithelial cells
  454. Evaluation of expression of p16INK4a & Survivin in squamous neoplasm of cervix-A 3 years study
  455. Evaluation of p16INK4a and Ki-67 proteins expression in cervical intraepithelial neoplasia and their correlation with HPV-HR infection
  456. Evaluation of p16INK4a and pRb expression in cervical squamous and glandular neoplasia
  457. Evaluation of p16INK4a as a Biomarker in Cervical Intraepithelial Neoplasia
  458. Evaluation of p16INK4a as a diagnostic tool in the triage of Pap smears demonstrating atypical squamous cells of undetermined significance
  459. Evaluation of p16INK4a expression in ThinPrep cervical specimens with the CINtec p16INK4a assay: Correlation with biopsy follow‐up results
  460. Evaluation of p16INK4a immunostaining for the detection of high-grade changes in cervical cytology
  461. Evaluation of p16INK4a in cervical lesion of premenopausal and postmenopausal women
  462. Evaluation of p16INK4a overexpression in a large series of cervical carcinomas: concordance with SPF10-LiPA25 PCR
  463. Evaluation of p16INK4a, minichromosome maintenance protein 2, DNA topoisomerase IIα, ProEX C, and p16INK4a/ProEX C in cervical squamous intraepithelial …
  464. Evaluation of p16INK4a, minichromosome maintenance protein 2, DNA topoisomerase IIα, ProEx C, and p16INK4a/ProEx C in cervical squamous intraepithelial …
  465. Evaluation of p16INK4a/Ki‐67 dual stain in comparison with an mRNA human papillomavirus test on liquid‐based cytology samples with low‐grade squamous …
  466. Evaluation of the expression of p16INK4a by immunohistochemistry in post-neoadjuvant chemotherapy hormone receptor negative breast cancer specimens
  467. Evaluation of UHRF1 and p16INK4a expression levels in newly diagnosed AML patients
  468. Evidence for at least three alternative mechanisms targeting the p16INK4a/cyclin D/Rb pathway in penile carcinoma, one of which is mediated by high‐risk human …
  469. Evidence that P12, a specific variant of p16INK4a, plays a suppressive role in human pancreatic carcinogenesis
  470. Evidence that senescent human prostate epithelial cells enhance tumorigenicity: cell fusion as a potential mechanism and inhibition by p16INK4a and hTERT
  471. EVOLUTION OF TUMOR SUPPRESSOR p16INK4a EXPRESSION IN CERVICAL CARCINOMA AMONG IRAQI WOMEN PATIENTS
  472. Exogenous expression of p16INK4a is associated with decrease in telomerase activity
  473. Exogenous wild-type p16INK4a gene induces delayed cell proliferation and promotes chemosensitivity through decreased pRB and increased E2F-1 expressions
  474. Exon 11 mutations, Ki67, and p16INK4a as predictors of prognosis in patients with GIST
  475. Exploration of tumor suppressors p16INK4a and p14ARF in oral leukoplakias
  476. Exploring galectin-3-KRASmut-p16INK4a interplay in colorectal cancer
  477. Expresión de p16INK4a, MCM2/TOPII y REST y estado físico del VPH 16 en el seguimiento de lesiones tempranas del cérvix uterino en mujeres guerrerenses
  478. Expression and characterization of Syrian golden hamster p16, a homologue of human tumor suppressor p16INK4a
  479. Expression and clinical significance of p16INK4a in human primary mesangial proliferative glomerulo-nephritis
  480. Expression and clinical significance of PML, P53 and p16INK4a in lung cancer
  481. Expression and clinical values of HPV L1 and p16INK4a protein in uterine cervical lesions
  482. Expression and Promoter Methylation of p16INK4a During Estrogen-Induced Mammary Carcinogenesis in the ACI Rat
  483. Expression and significance of MCM5 and p16INK4a in cervical squamous cell carcinoma
  484. Expression and significance of p16INK4a and PTEN in high-risk human papillomavirus-related cervical cancer
  485. Expression of a p16INK4a-specific ribozyme downmodulates p16INK4a abundance and accelerates cell proliferation
  486. Expression of ASPP2 and p16INK4a and its relationship with apoptosis in esophageal carcinoma
  487. Expression of Bcl-2, p16INK4a, and Cyclin D1 Proteins in Squamous Cell Carcinoma of the Lip
  488. Expression of cell-cycle mediators in ovarian cancer cells after transfection with p16INK4a, p21WAF1/Cip-1, and p53
  489. Expression of Chr9p21 genes CDKN2B (p15INK4b), CDKN2A (p16INK4a, p14ARF) and MTAP in human atherosclerotic plaque
  490. Expression of DNA methyltransferase 1 is activated by hepatitis B virus X protein via a regulatory circuit involving the p16INK4a-cyclin D1-CDK 4/6-pRb-E2F1 pathway
  491. Expression of E6/E7 mRNA from ‘high risk’human papillomavirus in relation to CIN grade, viral load and p16INK4a
  492. Expression of Fhit, Mlh1, p16INK4a and E-cadherin in early gastric neoplasia: Correlation with histological grade and gastric phenotype
  493. Expression of human papilloma virus (HPV) and p16INK4a in cervical intraepithelial neoplasia (CIN) and papilloma
  494. Expression of human papillomavirus L1 capsid protein and tumor suppressor gene p16INK4a and their relevance in cervical lesions
  495. Expression of p14ARF, p15INK4b, p16INK4a and skp2 increases during esophageal squamous cell cancer progression
  496. Expression of p14ARF, p16INK4a and p53 in relation to HPV in (pre‐)malignant squamous skin tumours
  497. Expression of p16INK4a and alterations of the 9p21‐23 chromosome region in non‐small‐cell lung carcinomas: Relationship with tumor growth parameters and …
  498. Expression of p16INK4a and cervical infection with high-risk human papillomavirus are not related to p53 activity in cervical intraepithelial neoplasia
  499. Expression of p16INK4a and human papillomavirus 16 with associated risk factors in cervical premalignant and malignant lesions
  500. Expression of p16INK4a and MIB-1 in relation to histopathology and HPV types in cervical adenocarcinoma
  501. Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney
  502. Expression of p16INK4a as a biomarker of T‐cell aging in HIV‐infected patients prior to and during antiretroviral therapy
  503. Expression of p16INK4a but not hypoxia markers or poly adenosine diphosphate‐ribose polymerase is associated with improved survival in patients with pancreatic …
  504. Expression of p16INK4a compensates for p18Ink4c loss in cyclin-dependent kinase 4/6–dependent tumors and tissues
  505. Expression of p16INK4a in ameloblastoma: Immunohistochemical and FISH analysis
  506. Expression of p16INK4a in cervical precancerous lesions is unlikely to be preventable by human papillomavirus vaccines
  507. Expression of p16INK4a in Endometrioid Cancer Rat Model
  508. Expression of p16INK4a in gastrointestinal stromal tumours (GISTs): two different forms exist that independently correlate with poor prognosis
  509. Expression of p16INK4a in mixed squamous cell and glandular papilloma of the lung
  510. Expression of p16INK4a in nucleus pulposus and its effect on degenerated intervertebral discs
  511. Expression of p16INK4a in Pap smears containing atypical glandular cells from the uterine cervix
  512. Expression of p16INK4a in Papanicolaou smears containing atypical squamous cells of undetermined significance from the uterine cervix
  513. Expression of p16INK4a in peripheral blood T‐cells is a biomarker of human aging
  514. Expression of p16INK4a in relation to histopathology and viral load of ‘high-risk’HPV types in cervical neoplastic lesions
  515. Expression of p16INK4a in testis of rhesus monkey during heat stress and testosterone undecanoate induced azoospermia or oligozoospermia☆
  516. Expression of p16INK4a in various cancer cells
  517. Expression of p16INK4a induces dominant suppression of glioblastoma growth in situ through necrosis and cell cycle arrest
  518. Expression of p16INK4a prevents cancer and promotes aging in lymphocytes
  519. Expression of p16INK4a Protein in Cervical Intraepithelial Neoplasia and Invasive Carcinoma of Uterine Cervix
  520. Expression of p16INK4a Protein in Colorectal Cancer Patients
  521. Expression of p16INK4a Protein in Colorectal Cancer Patients
  522. Expression of p16INK4a variants in senescent human fibroblasts independent of protein phosphorylation
  523. Expression of p16INK4a, CyclinD1, Ki-67 and HPV infection in cervical squamous cell carcinoma.
  524. Expression of p16INK4a, p15INK4b, p21WAF1/Clip1 cell cycle inhibitors on blastic cells in patients with acute myeloblastic leukemia (AML) and acute lymphoblastic …
  525. Expression of p16INK4a, p53, and Rb proteins are independent from the presence of human papillomavirus genes in oral squamous cell carcinoma
  526. Expression of p16INK4a/p16α and p19ARF/p16β is frequently altered in non-small cell lung cancer and correlates with p53 overexpression
  527. Expression of p16INK4aSuppresses the Unbounded and Anchorage-Independent Growth of a Glioblastoma Cell Line That Lacks p16INK4a
  528. Expression of P27, P21WAF/Cip1, and p16INK4a in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma
  529. Expression of p53, p16INK4a, pRb, p21WAF1/CIP1, p27KIP1, cyclin D1, Ki-67 and HPV DNA in sinonasal endophytic Schneiderian (inverted) papilloma
  530. Expression of p53, p21WAF1/CIP1, p16INK4a and Ki-67 proteins in serous ovarian tumors
  531. Expression of survivin and p16INK4a/Cdk6/pRB proteins and induction of apoptosis in response to radiation and cisplatin in meningioma cells
  532. Expression of the cell cycle regulators p14ARF and p16INK4a in chronic myeloid leukemia
  533. Expression of the cell cycle regulators p53, p21WAF1/CIP1 and p16INK4a in human endometrial adenocarcinoma
  534. Expression of the cell-cycle regulatory proteins (pRb, cyclin D1, p16INK4a and cdk4) in human endometrial cancer: correlation with clinicopathological features
  535. Expression of the p16INK4a and Ki-67 in relation to the grade of cervical intraepithelial neoplasia and high-risk human papillomavirus infection
  536. Expression of the p16INK4a gene and methylation pattern of CpG sites in the promoter region in rat tumor cell lines
  537. Expression of the p16INK4a gene is associated closely with senescence of human mesenchymal stem cells and is potentially silenced by DNA methylation during in …
  538. Expression of the p16INK4a gene product, methylation of the p16INK4a promoter region and expression of the polycomb-group gene BMI-1 in squamous cell lung …
  539. Expression of the p16INK4a tumor suppressor correlates with adverse clinical outcome in follicular lymphoma
  540. Expression of the p16INK4a/Cdkn2a gene is prevalently downregulated in human pheochromocytoma tumor specimens
  541. Expression of the protein marker p16INK4a in the cervix uteri cancer
  542. Expression of the tumormarker p16INK4a in cytology specimens of the urinary bladder. A new means for early recognition and surveillance of urothelial cancer
  543. Expression of thymidylate synthase in human cells is an early G1 event regulated by CDK4 and p16INK4a but not E2F
  544. Expression profiles of p53-, p16INK4a-, and telomere-regulating genes in replicative senescent primary human, mouse, and chicken fibroblast cells
  545. Expressions of MCM5 and p16INK4a in cervical squamous cell carcinoma
  546. Expressions of p16INK4a gene and Bmi1 gene in human corneal endothelial cells of different ages
  547. Expressions of p16INK4a protein in cervical lesion tissues of Mongolian patients and their significances
  548. Extremely stringent activation of p16INK4a prevents immortalization of uterine cervical epithelial cells without human papillomavirus oncogene expression
  549. FBXL16 is a novel E2F1-regulated gene commonly upregulated in p16INK4a-and p14ARF-silenced HeLa cells
  550. Features of replicative senescence induced by direct addition of antennapedia‐p16INK4a fusion protein to human diploid fibroblasts
  551. Fine-mapping loss of gene architecture at the CDKN2B (p15INK4b), CDKN2A (p14ARF, p16INK4a), and MTAP genes in head and neck squamous cell carcinoma
  552. Forced expression of the cyclin-dependent kinase inhibitor p16INK4a in leukemic U-937 cells reveals dissociation between cell cycle and differentiation
  553. Forkhead-box A1 induces cell senescence in endometrial cancer by regulating p16INK4a
  554. FOXA1 mediates p16INK4a activation during cellular senescence
  555. Frequency of genetic and epigenetic alterations of p14ARF and p16INK4a in head and neck cancer in a Hungarian population
  556. Frequency of p16INK4a alterations and k-ras mutations in intrahepatic cholangiocarcinoma of the liver
  557. Frequency of p16INK4a and P14ARF genes methylation and its impact on bladder cancer cases in north Indian population
  558. Frequent aberrant methylation of p16INK4a in primary rat lung tumors.
  559. Frequent alteration of p16INK4a/p14ARF and p53 pathways in the round cell component of myxoid/round cell liposarcoma: p53 gene alterations and reduced p14ARF …
  560. Frequent alterations of p16INK4a and p14ARF in oral proliferative verrucous leukoplakia
  561. Frequent alterations of the p14ARF and p16INK4a genes in primary central nervous system lymphomas
  562. Frequent deletion of p16INK4a/MTS1 and p15INK4b/MTS2 in pediatric acute lymphoblastic leukemia
  563. Frequent loss of 9p21 (p16INK4a) and other genomic imbalances in human malignant fibrous histiocytoma
  564. Frequent loss of the p16INK4a gene product in human pituitary tumors
  565. Frequent methylation of p16INK4a and p14ARF genes implicated in the evolution of chronic myeloid leukaemia from its chronic to accelerated phase
  566. Frequent methylation of p16INK4a/p14ARF promoters in tumorigenesis of Epstein-Barr virus transformed lymphoblastoid cell lines
  567. Frequent p16INK4a inactivation is an early and frequent event of intraductal papillary neoplasm of the liver arising in hepatolithiasis
  568. Frequent p16INK4a promoter hypermethylation in human papillomavirus‐infected female lung cancer in Taiwan
  569. Frequent promoter hypermethylation of RASSF1A and p16INK4a and infrequent allelic loss other than 9p21 in betel‐associated oral carcinoma in a Vietnamese non …
  570. Frequent Upregulation of Cyclin D1 and p16INK4a Expression with Low Ki-67 Scores in Multinucleated Giant Cells
  571. Functional analysis of CDKN2A/p16INK4a 5′-UTR variants predisposing to melanoma
  572. Functional availability of γ-herpesvirus K-cyclin is regulated by cellular CDK6 and p16INK4a
  573. Functional impairment of melanoma-associated p16INK4a mutants in melanoma cells despite retention of cyclin-dependent kinase 4 binding
  574. Functional impairment of p16INK4a due to CDKN2A p. Gly23Asp missense mutation
  575. Gaba-betaine modulates SIRT1 and p16INK4a expression during high-glucose induced endothelial cell senescence
  576. GAPDH expression as a measurement of transfection efficiency for p16INK4a gene silencing (siRNA) in senescent human diploid fibroblasts
  577. Gene Expression Status and Methylation Pattern in Promoter of P15INK4b and p16INK4a in Cord Blood CD34 Stem Cells
  578. Gene expression status and methylation pattern in promoter of P15INK4b and p16INK4a in cord blood CD34+ stem cells
  579. Generation and evaluation of chimeric particles consisting of HPV16 L1 and p16INK4a for second generation HPV vaccines
  580. Generation of HBsAg (S) particles carrying combined HPV-16E7 and p16INK4a epitopes and their immunogenicity in vitro
  581. Genetic Ablation of p16INK4a Does Not Protect against Cellular Senescence in Mouse Models of Chronic Obstructive Pulmonary Disease/Emphysema
  582. Genetic alterations of p16INK4a and p14ARF genes in human bladder cancer
  583. Genetic and epigenetic alterations of the cyclin‐dependent kinase inhibitors p15INK4b and p16INK4a in human thyroid carcinoma cell lines and primary thyroid …
  584. Genistein induces the p21WAF1/CIP1 and p16INK4a tumor suppressor genes in prostate cancer cells by epigenetic mechanisms involving active chromatin …
  585. Genomic instability, mutations and expression analysis of the tumour suppressor genes p14ARF, p15INK4b, p16INK4a and p53 in actinic keratosis
  586. Germline CDKN2A/p16INK4a mutations contribute to genetic determinism of sarcoma
  587. Germline p16INK4a mutation and protein dysfunction in a family with inherited melanoma.
  588. Global increase of p16INK4a in APC-deficient mouse liver drives clonal growth of p16INK4a-negative tumors
  589. Grading immunohistochemical markers p16INK4a and HPV E4 identifies productive and transforming lesions caused by low‐ and high‐risk HPV within high‐grade …
  590. Green tea polyphenols reactivate silenced tumor suppressor genes, p16INK4a and Cip1/p21, by reducing DNA methylation and increasing histone acetylation in UV …
  591. GRIM-19 and p16INK4a synergistically regulate cell cycle progression and E2F1-responsive gene expression
  592. Growth arrest and suppression of tumorigenicity of bladder carcinoma cell lines induced by the P16/CDKN2 (p16INK4a, MTS1) gene and other loci on human …
  593. H3K27 trimethylation is an early epigenetic event of p16INK4a silencing for regaining tumorigenesis in fusion reprogrammed hepatoma cells
  594. H3K9me-Enhanced DNA Hypermethylation of the p16INK4a Gene: An Epigenetic Signature for Spontaneous Transformation of Rat Mesenchymal Stem Cells
  595. Hemizygous or homozygous deletion of the chromosomal region containing the p16INK4a gene is associated with amplification of the EGF receptor gene in …
  596. Hepatitis B virus X protein induces hypermethylation of p16INK4a promoter via DNA methyltransferases in the early stage of HBV‐associated hepatocarcinogenesis
  597. Hepatitis B virus X protein overcomes stress-induced premature senescence by repressing p16INK4a expression via DNA methylation
  598. Hepatitis B virus X protein promotes hypermethylation of p16INK4a promoter through upregulation of DNA methyltransferases in hepatocarcinogenesis
  599. Hepatocyte growth factor induces redistribution of p21CIP1 and p27KIP1 through ERK-dependent p16INK4a up-regulation, leading to cell cycle arrest at G1 in HepG2 …
  600. Hereditary TP53 codon 292 and somatic p16INK4a codon 94 mutations in a Li-Fraumeni syndrome family
  601. HFE polymorphisms influence the response to chemotherapeutic agents via induction of p16INK4a
  602. High ALDH1, S phase fraction, p16INK4a in esophageal squamous cell carcinoma could predict response to neoadjuvant chemotherapy
  603. High expression of p16INK4a and low expression of Bmi1 are associated with endothelial cellular senescence in the human cornea
  604. High frequency deletion of the tumour suppressor gene p16INK4a (MTS1) in human thyroid cancer cell lines
  605. High frequency methylation of p16INK4a gene during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis
  606. High frequency of homozygous deletion and methylation of p16INK4a gene in oral squamous cell carcinomas
  607. High frequency of loss of heterozygosity on chromosome region 9p21–p22 but lack of p16INK4a/p19arf mutations in Greek patients with basal cell carcinoma …
  608. High frequency of p16INK4a promoter methylation in NRAS-mutated cutaneous melanoma
  609. High prevalence of the G101W germline mutation in the CDKN2A (p16INK4a) gene in 62 Italian malignant melanoma families
  610. High-risk HPV E6/E7 mRNA in situ hybridization in endocervical glandular neoplasia: performance compared with p16INK4a and Ki67 immunochemistry
  611. High-risk HPV genotypes and p16INK4a expression in a cohort of head and neck squamous cell carcinoma patients in Singapore
  612. High-risk HPV infection and CIN grade correlates to the expression of c-myc, CD4+, FHIT, E-cadherin, Ki-67, and p16INK4a
  613. High-risk human papillomavirus DNA test and p16INK4a in the triage of LSIL: a prospective diagnostic study
  614. High-risk human papillomavirus infection and p16INK4a protein expression in laryngeal lesions
  615. High‐density methylation of p14ARF and p16INK4a in Epstein‐Barr virus–associated gastric carcinoma
  616. Histologically normal human mammary epithelia with silenced p16INK4a overexpress COX-2, promoting a premalignant program
  617. Histone deacetylase 3 (HDAC3) participates in the transcriptional repression of the p16INK4a gene in mammary gland of the female rat offspring exposed to an early …
  618. Histone deacetylase inhibitor suppression of autoantibody‐mediated arthritis in mice via regulation of p16INK4a and p21WAF1/Cip1 expression
  619. Histone demethylase KDM2B promotes triple negative breast cancer proliferation by suppressing p15INK4B, p16INK4a, and p57KIP2 transcription
  620. Histopathological Analysis and Role of p16INK4a as a Diagnostic Marker in Uterine Cervical Neoplasms
  621. Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16INK4a and p19Arf Expression
  622. Homozygous codeletion and differential decreased expression of p15INK4b, p16INK4a-alpha and p16INK4a-beta in mouse lung tumor cells.
  623. Homozygous deletion of CDKN2A (p16INK4a/p14ARF) but not within 1p36 or at other tumor suppressor loci in neuroblastoma
  624. Homozygous deletion of p16INK4a and tobacco carcinogen exposure in nonsmall cell lung cancer
  625. Homozygous Deletion of the p16INK4a Gene Occurs More Frequently in CD2+ Than in CD2− T-Cell Acute Lymphoblastic Leukemia
  626. Homozygous deletions of p16INK4a/MTS1 and p15INK4B/MTS2 genes in glioma cells and primary glioma tissues
  627. How is the mutational status for tumor suppressors p53 and p16INK4a in MFH of the bone?
  628. How to measure RNA expression in rare senescent cells expressing any specific protein such as p16INK4a
  629. Hoxa9 silencing of p16INK4a is essential for murine lymphopoiesis
  630. HPV 16-associated tonsillar carcinomas show p16INK4a over-expression and an improved prognosis
  631. HPV DNA genotyping and methylation of gene p16INK4a in cervical LSIL
  632. HPV DNA, E6* I-mRNA expression and p16INK4a immunohistochemistry in head and neck cancer–How valid is p16INK4a as surrogate marker?
  633. HPV DNA, E6/E7 mRNA, and p16INK4a detection in head and neck cancers: a systematic review and meta-analysis
  634. HPV DNA, p16INK4a and mRNA E6* I detection in anogenital cancers
  635. HPV infection and p16INK4a and TP53 expression in rare cancers of the uterine cervix
  636. HPV-16 E6 silencing of p16INK4a in human cervical cancer cells
  637. HPV-related oropharyngeal squamous cell carcinoma: p16INK4a immunohistochemistry or HPV genotyping?
  638. HPV-related Vulvar Diseases and Perspectives of p16INK4a Immunochemistry: A Review of the Literature
  639. Hsa‐let‐7g inhibits proliferation of hepatocellular carcinoma cells by downregulation of c‐Myc and upregulation of p16INK4a
  640. HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4a and counteracts its inhibitory activity to CDK4.
  641. HTLV‐1 Tax protein interacts with cyclin‐dependent kinase inhibitor p16INK4a and counteracts its inhibitory activity towards CDK4.
  642. Human astrocytes exhibit an increased expression of the cellular senescence biomarker p16INK4a in aged human brain and Alzheimer’s Disease
  643. Human glioblastomas with no alterations of the CDKN2A (p16INK4a, MTS1) and CDK4 genes have frequent mutations of the retinoblastoma gene.
  644. Human keratinocytes that express hTERT and also bypass a p16INK4a-enforced mechanism that limits life span become immortal yet retain normal growth and …
  645. Human Keratinocytes That Express hTERT and Also Bypass a p16INK4a-Enforced Mechanism That Limits Life Span Become…
  646. Human papilloma virus (HPV) status, p16INK4a, and p53 overexpression in epithelial malignant and borderline ovarian neoplasms
  647. Human Papillomavirus and Overexpression of p16INK4a in Nonmelanoma Skin Cancer
  648. Human papillomavirus detection and p16INK4a expression in cervical lesions: a comparative study
  649. Human papillomavirus DNA and p16INK4a expression in concurrent esophageal and gastric cardia cancers
  650. Human papillomavirus DNA and p16INK4a expression in hypopharyngeal cancer and in relation to clinical outcome, in Stockholm, Sweden
  651. Human papillomavirus DNA detection, p16INK4a, and oral cavity cancer in a US population
  652. Human papillomavirus DNA load and p16INK4a expression predict for local control in patients with anal squamous cell carcinoma treated with chemoradiotherapy
  653. Human papillomavirus genotypes and p16INK4a expression in squamous penile carcinoma in Mexican patients
  654. Human Papillomavirus genotyping and p16INK4a expression in cervical lesions: a combined test to avoid cervical cancer progression
  655. Human papillomavirus genotyping by oligonucleotide microarray and p16INK4a expression in uterine cervical intraepithelial neoplasm and in invasive carcinoma in …
  656. Human papillomavirus infection and immunohistochemical p16INK4a expression as predictors of outcome in penile squamous cell carcinomas
  657. Human papillomavirus infection and p16INK4a protein expression in vulvar intraepithelial neoplasia and invasive squamous cell carcinoma
  658. Human Papillomavirus Infection, p16INK4a Expression and Genetic Alterations in Vietnamese Cervical Neuroendocrine Cancer
  659. Human papillomavirus status and p16INK4a expression in patients with mucosal squamous cell carcinoma of the head and neck in Queensland, Australia
  660. Human papillomavirus‐associated increase in p16INK4a expression in penile lichen sclerosus and squamous cell carcinoma
  661. Human papillomavirus, Epstein‐Barr virus, and methylation status of p16INK4a in penile cancer
  662. Human papillomaviruses, expression of p16INK4a, and early endocervical glandular neoplasia
  663. Human T-cell leukemia virus type 1 Tax releases cell cycle arrest induced by p16INK4a.
  664. Hydrogen peroxide induces p16INK4a through an AUF1‐dependent manner
  665. Hyperemethylation of p16INK4a is associated with cervical neoplasia
  666. Hypermethylation Analysis of p16INK4a and p15INK4b Promoters in Chronic Lymphocytic Leukaemia Patients and Normal Individuals
  667. Hypermethylation can selectively silence individual p16INK4a alleles in neoplasia
  668. Hypermethylation of E-cadherin gene is frequent and independent of p16INK4a methylation in non-small cell lung cancer: potential prognostic implication
  669. Hypermethylation of hMLH1, HPP1, p14ARF, p16INK4a and APC in primary adenocarcinomas of the small bowel
  670. Hypermethylation of p16INK4a and P15ink4b genes as a marker of disease in the follow‐up of non‐Hodgkin’s lymphomas
  671. Hypermethylation of p16INK4a and p15INK4b genes in non-small cell lung cancer
  672. Hypermethylation of p16INK4a in Korean non-small cell lung cancer patients
  673. Hypermethylation of promoter regions of the APC1A and p16INK4a genes in relation to prognosis and tumor characteristics in cervical cancer patients
  674. Hypermethylation of the CDKN2/p16INK4a promotor in thyroid carcinogenesis
  675. Hypermethylation of the P15INK4b and p16INK4a in agnogenic myeloid metaplasia (AMM) and AMM in leukaemic transformation
  676. Hypermethylation of the p16INK4a promoter in colectomy specimens of patients with long-standing and extensive ulcerative colitis
  677. Hypermethylation of tumor suppressor genes (p16INK4a, p14ARF and APC) in adenocarcinomas of the upper gastrointestinal tract
  678. Hypermethylation-associated inactivation of p14ARF is independent of p16INK4a methylation and p53 mutational status
  679. hYSK1 promotes cancer cell proliferation and migration through negative regulation of p16INK4a under hypoxic conditions
  680. Identification and characterization of a novel protein ISOC2 that interacts with p16INK4a
  681. Identification and sequencing of the Syrian Golden hamster (Mesocricetus auratus) p16INK4a and p15INK4b cDNAs and their homozygous gene deletion in cheek …
  682. Identification of a splice acceptor site mutation in p16INK4a/p14ARF within a breast cancer, melanoma, neurofibroma prone kindred
  683. Identification of high‐grade cervical dysplasia by the detection of p16INK4a in cell lysates obtained from cervical samples
  684. Identification of target genes of the p16INK4a-pRB-E2F pathway
  685. IL-6 Predicts p16INK4a Expression, Intracellular Tenofovir/Emtricitabine Exposure, and Endogenous Nucleotide Pools in Adults with HIV
  686. Immortalization of bovine capillary endothelial cells by hTERT alone involves inactivation of endogenous p16INK4a/pRb
  687. Immortalization of Human Fetal Cells: The Life Span of Umbilical Cord Blood-derived Cells Can Be Prolonged without Manipulating p16INK4a/RB Braking Pathway
  688. Immuno-Histochemical Study of p16INK4a in Cervical Intraepithelial Neoplasia and Cervical Cancer
  689. Immunocytochemical colocalization of p16INK4a and Ki‐67 predicts CIN2/3 and AIS/adenocarcinoma Pilot studies
  690. Immunocytochemical detection of p16INK4a protein for the identification of patients at risk of cervical cancer
  691. Immunocytochemical detection of p16INK4a protein in scraped cervical cells.
  692. Immunocytochemical expression of p16INK4a and Ki-67 in cytologically negative and equivocal pap smears positive for oncogenic human papillomavirus
  693. Immunocytochemical expression of P53, PTEN, FAS (CD95), p16INK4a and HPV L1 major capsid proteins in ThinPrep cervical samples with squamous intraepithelial …
  694. Immunocytochemical staining of p16INK4a protein as an adjunct test in equivocal liquid‐based cytology
  695. Immunocytochemical staining of p16INK4a protein from conventional Pap test and its association with human papillomavirus infection
  696. Immunocytochemical Studies of Cyclin D1 and p16INK4a in Acute Lymphoblastic Leukemic Patients
  697. Immunocytochemistry (p16INK4a) as an additional examination for cytological specimens Class III D (Munich Classification II)
  698. Immunocytochemistry of p16INK4a in liquid-based cervicovaginal specimens with modified Papanicolaou counterstaining
  699. Immunoexpression of p16INK4a, Rb and TP53 proteins in bronchiolar columnar cell dysplasia (BCCD) in lungs resected due to primary non-small cell lung cancer.
  700. Immunofluorescence expression of Ki-67, p53 and cyclin inhibitors (p16INK4a, p21 and p27) in low-grade cervical lesions versus high-grade cervical lesions …
  701. Immunohistochemical Analysis of Abnormal p16INK4a Protein Expression in Human Breast Cancer.
  702. Immunohistochemical analysis of p16INK4a, p14ARF, p18INK4c, p21CIP1, p27KIP1 and p73 expression in 271 meningiomas correlation with tumor grade and …
  703. Immunohistochemical analysis of pRb2/p130, VEGF, EZH2, p53, p16INK4a, p27KIP1, p21WAF1, Ki‐67 expression patterns in gastric cancer
  704. Immunohistochemical analysis of thymidylate synthase, p16INK4a, cyclin‐dependent kinase 4 and cyclin D1 in colorectal cancers receiving preoperative chemotherapy …
  705. Immunohistochemical and molecular study of p16INK4a expression in pituitary adenoma
  706. Immunohistochemical detection of p16INK4a in leukoplakia and oral squamous cell carcinoma
  707. Immunohistochemical detection of p16INK4a in liquid‐based cytology specimens on cell block sections
  708. Immunohistochemical detection of the cyclin-dependent kinase inhibitor 2/multiple tumor suppressor gene 1 (CDKN2/MTS1) product p16INK4a in archival human …
  709. Immunohistochemical Evaluation of p16INK4a, E-Cadherin, and Cyclin D1 Expression in Melanoma and Spitz Tumors
  710. Immunohistochemical Evaluation of Thymidylate Synthase (TS) and p16INK4a in Advanced Colorectal Cancer: Implication of TS Expression in 5-FU-based Adjuvant …
  711. Immunohistochemical expression of cyclin D1, p16INK4a, p21WAF1, and Ki-67 correlates with the severity of cervical neoplasia
  712. Immunohistochemical expression of Ki-67, Cyclin D1, p16INK4a, and Survivin as a predictive tool for recurrence and progression-free survival in papillary urothelial …
  713. Immunohistochemical Expression of p16INK4a and bcl-2 According to HPV Type and to the Progression of Cervical Squamous Intraepithelial Lesions
  714. Immunohistochemical expression of p16INK4a in inflammatory, preneoplastic and neoplastic cervical lesions
  715. Immunohistochemical expression of p16INK4a protein as a helpful marker of a subset of potentially malignant oral epithelial lesions: study on a series with long‐term …
  716. Immunohistochemical expression of p16INK4a protein in oral lichen planus
  717. Immunohistochemical Expression of the Tumor Suppressor Protein p16INK4a in Cervical Adenocarcinoma
  718. Immunohistochemical staining for p16INK4a selectively detects human papillomavirus-related premalignant and malignant vulvar lesions
  719. Immunohistochemical survey of p16INK4a expression in normal human adult and infant tissues.
  720. Immunohistochemistry: Poster# 232 THE UTILITY OF p16INK4a EXPRESSION IN UTERINE CERVICAL BIOPSIES REPORTED NEGATIVE AND POSITIVE FOR …
  721. Immunohistological Expression of p16INK4a is Commonly Present Both in Benign and Malignant Sweat Gland Neoplasias.
  722. Immunostaining for p16INK4a used as a conjunctive tool improves interobserver agreement of the histologic diagnosis of cervical intraepithelial neoplasia
  723. Immunostaining for polycomb group protein EZH2 and senescent marker p16INK4a may be useful to differentiate cholangiolocellular carcinoma from ductular reaction …
  724. Immunostaining of p16INK4a/Ki-67 and L1 capsid protein on liquid-based cytology specimens obtained from ASC-H and LSIL-H cases
  725. Impact of methylation of the p16INK4a gene on the prognosis ofhead and neck squamous cell carcinoma patients
  726. Impact of novel CDKN2A/p16INK4a 5’UTR variants predisposing to melanoma on p16 translational regulation
  727. Impact of p16INK4a and p15INK4B on human hepatocellular carcinoma cell proliferation and apoptosis
  728. Impact of p16INK4a Immunohistochemistry Staining on Interobserver Agreement on the Diagnosis of Cervical Intraepithelial Neoplasia
  729. Impact of utilizing p16INK4a immunohistochemistry on estimated performance of three cervical cancer screening tests
  730. Impaired cell cycle check-point control and increased tumorigenesis by loss of p16INK4a
  731. Impaired inhibition of NF-κB activity by melanoma-associated p16INK4a mutations
  732. Impaired Processing of DNA Photoproducts and Ultraviolet Hypermutability With Loss of p16INK4a or p19ARF
  733. Implication of polycomb members Bmi-1, Mel-18, and Hpc-2 in the regulation of p16INK4a, p14ARF, h-TERT, and c-Myc expression in primary breast carcinomas
  734. Implication of USP22 in the regulation of BMI-1, c-Myc, p16INK4a, p14ARF, and cyclin D2 expression in primary colorectal carcinomas
  735. Implications of genetic and epigenetic alterations of CDKN2A (p16INK4a) in cancer
  736. Improving Early Diagnosis of Cervical Cancer Lesions Using p16INK4a Biomarkers on Cellblocks from Cervical Smears
  737. In silico analysis of structural and functional consequences in p16INK4a by deleterious nsSNPs associated CDKN2A gene in malignant melanoma
  738. In vitro and in vivo tumor growth inhibition by a p16‐mimicking peptide in p16INK4a‐defective, pRb‐positive human melanoma cells
  739. In vitro drug resistance and prognostic impact of p16INK4a/P15INK4B deletions in childhood T‐cell acute lymphoblastic leukaemia
  740. In vitro study examining the effect of sub‐lethal QS 755 nm lasers on the expression of p16INK4a on melanoma cell lines
  741. Inactivation mechanisms and growth suppressive effects of p16INK4a in Asian esophageal squamous carcinoma cell lines
  742. Inactivation of multiple tumor-suppressor genes involved in negative regulation of the cell cycle, MTS1/p16INK4a/CDKN2, MTS2/p15INK4B, p53, and Rb genes in …
  743. Inactivation of p16INK4a (inhibitor of cyclin-dependent kinase 4A) immortalizes primary human keratinocytes by maintaining cells in the stem cell compartment
  744. Inactivation of p16INK4a by CpG hypermethylation is not a frequent event in colorectal cancer
  745. Inactivation of p16INK4a expression in malignant mesothelioma by methylation
  746. Inactivation of p16INK4a, with retention of pRB and p53/p21cip1 function, in human MRC5 fibroblasts that overcome a telomere-independent crisis during …
  747. Inactivation of the Dlc1 gene cooperates with downregulation of p15INK4b and p16INK4a, leading to neoplastic transformation and poor prognosis in human cancer
  748. Inactivation of the p14ARF, p15INK4B and p16INK4a genes is a frequent event in human oral squamous cell carcinomas
  749. Inactivation of the p16INK4a gene by methylation is not a frequent event in sporadic ovarian carcinoma
  750. Inactivation of tumor suppressor genes p15INK4b and p16INK4a in primary cutaneous B cell lymphoma
  751. Incidence and Clinical Significance of CDKN2/MTS1/p16INK4a ND MTS2/P15ink4B Gene Deletions in Childhood Acute Lymphoblastic Leukemia
  752. Increased CDK4 protein expression predicts a poor prognosis in mucosal melanoma associated with the p16INK4a-CDK4-pRb pathway
  753. Increased expression of senescence markers p14ARF and p16INK4a in breast cancer is associated with an increased risk of disease recurrence and poor survival …
  754. Increased Expression of Senescence‐Associated Cell Cycle Inhibitor p16INK4a in Deteriorating Renal Transplants and Diseased Native Kidney
  755. Increased Expression of the Cyclin dependent Kinase Inhibitor p16INK4a in Helicobacter pylori-associated Chronic Gastritis
  756. Increased p16INK4a-expressing senescent bile ductular cells are associated with inadequate response to ursodeoxycholic acid in primary biliary cholangitis
  757. Increased γ-tubulin expression and p16INK4a promoter methylation occur together in preinvasive lesions and carcinomas of the breast
  758. Induction of p16INK4a and p19ARF by TGFβ1 contributes to growth arrest and senescence response in mouse keratinocytes
  759. Induction of p16INK4a is the major barrier to proliferation when Epstein-Barr virus (EBV) transforms primary B cells into lymphoblastoid cell lines
  760. Induction of p16INK4a mediated by β‐catenin in a TCF4‐independent manner: Implications for alterations in p16INK4a and pRb expression during trans …
  761. Induction of pRb degradation by the human papillomavirus type 16 E7 protein is essential to efficiently overcome p16INK4a-imposed G1 cell cycle Arrest
  762. Induction of the tumor-suppressor p16INK4a within regenerative epithelial crypts in ulcerative colitis
  763. Influence of human papillomavirus and p16INK4a on treatment outcome of patients with anal cancer
  764. Infrequent alterations of the p16INK4a gene in liver cancer
  765. Infrequent alternations of RB pathway (Rb-p16INK4a-cyclinD1) in adenoid cystic carcinoma of salivary glands.
  766. Infrequent mutations of p16INK4a and p15INK4B genes in human pituitary adenomas
  767. Inhibition of p16INK4a Protects Against Myocardial Ischemia/Reperfusion Injury
  768. Inhibition of pRb phosphorylation and cell cycle progression by an antennapedia-p16INK4a fusion peptide in pancreatic cancer cells
  769. Inhibition of T-cell acute lymphoblastic leukemia proliferation in vivo by re-expression of the p16INK4a tumor suppressor gene
  770. Inhibition of the H3K4 methyltransferase MLL1/WDR5 complex attenuates renal senescence in ischemia reperfusion mice by reduction of p16INK4a
  771. INK4a gene expression and methylation in primary breast cancer: overexpression of p16INK4a messenger RNA is a marker of poor prognosis
  772. Insertional mutagenesis in mice deficient for p15Ink4b, p16INK4a, p21Cip1, and p27Kip1 reveals cancer gene interactions and correlations with tumor phenotypes
  773. INSIGHTS AND PITFALLS OF A SELECTIVE p16INK4a IMMUNOHISTOCHEMICAL TESTING STRATEGY FOR ORAL SQUAMOUS CELL CARCINOMA AND …
  774. Interobserver reproducibility of cytologic p16INK4a/Ki‐67 dual immunostaining in human papillomavirus‐positive women
  775. Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK4a regulation
  776. Interpretation of p16INK4a/Ki‐67 dual immunostaining for the triage of human papillomavirus‐positive women by experts and nonexperts in cervical cytology
  777. Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo
  778. Introduction of p16INK4a inhibits telomerase activity through transcriptional suppression of human telomerase reverse transcriptase expression in human gliomas
  779. Invade or proliferate? Two contrasting events in malignant behavior governed by p16INK4a and an intact Rb pathway illustrated by a model system of basal cell …
  780. Invasion of normal human fibroblasts induced by v-Fos is independent of proliferation, immortalization, and the tumor suppressors p16INK4a and p53
  781. Inverse correlation between p16INK4a expression and NF-κB activation in melanoma progression
  782. Investigating Diagnostic Problems of CIN 1 and 2 Associated with High-Risk HPV by Combining the Novel Molecular Biomarker PanHPV E4 with p16INK4a
  783. Investigation of germline PTEN, p53, p16INK4a/p14ARF, and CDK4 alterations in familial glioma
  784. Investigation of p16INK4a and P14RF genes expression in different phase of Chronic Myeloid Leukemia (CML)
  785. Involvement of Bmi-1 gene in the development of gastrointestinal stromal tumor by regulating p16INK4a/p14ARF gene expressions: An in vivo and in vitro study
  786. Involvement of CDKN2 (p16INK4a/MTS1) and p15INK4B/MTS2 in human leukemias and lymphomas
  787. Ionizing Radiation Induces Hematopoietic Stem Cell Senescence and Long-Term Bone Marrow Suppression in a p16INK4a/Arf-Independent manner
  788. Is p16INK4a expression more useful than human papillomavirus test to determine the outcome of atypical squamous cells of undetermined significance-categorized …
  789. Is p16INK4a overexpression a reliable biomarker for oncogenic human papillomavirus infection in normal tonsils?
  790. Is p16INK4a protein expression in oral ST lesions a reliable precancerous marker?
  791. Is the expression of p16INK4a and galectin-3 correlated with disease progression of cervical neoplasia?
  792. Ischemia dysregulates DNA methyltransferases and p16INK4a methylation in human colorectal cancer cells
  793. JMJD3 Plays Essential Roles in the Maintenance of Hematopoietic Stem Cells and Leukemic Stem Cells through the Regulation of p16INK4a
  794. Jun dimerization protein 2 controls hypoxia‐induced replicative senescence via both the p16INK4a‐pRb and Arf‐p53 pathways
  795. JunB suppresses cell proliferation by transcriptional activation of p16INK4a expression
  796. K‐ras oncogene subtype mutations are associated with survival but not expression of p53, p16INK4a, p21WAF‐1, cyclin D1, erbB‐2 and erbB‐3 in resected …
  797. KDM6A regulates cell proliferation, invasion and apoptosis by transcriptional inhibits p16INK4a
  798. KLRG1 impairs CD4+ T cell responses via p16INK4a and p27kip1 pathways: role in hepatitis B vaccine failure in individuals with hepatitis C virus infection
  799. Knockout of Canopy 2 activates p16INK4a pathway to impair cardiac repair
  800. Knockout of p16INK4a promotes aggregative growth of dermal papilla cells
  801. Lack of mutation at p16INK4a gene but expression of aberrant p16INK4a RNA transcripts in human ovarian carcinoma
  802. Lack of p16INK4a over expression in penile squamous cell carcinoma is associated with recurrence after lymph node dissection
  803. Latent membrane protein 1 encoded by Epstein–Barr virus induces telomerase activity via p16INK4a/Rb/E2F1 and JNK signaling pathways
  804. Local immune response depends on p16INK4a status of primary tumor in vulvar squamous cell carcinoma
  805. Long-term cultured IL-2-dependent T cell lines demonstrate p16INK4a overexpression, normal pRb/p53, and upregulation of cyclins E or D2
  806. Long‐term arsenic exposure induces histone H3 Lys9 dimethylation without altering DNA methylation in the promoter region of p16INK4a and down‐regulates its …
  807. Long‐term growth arrest of PUVA‐treated fibroblasts in G2/M in the absence of p16INK4a, p21CIP1 or p53
  808. Loss of 9p leads to p16INK4a down‐regulation and enables RB/E2F1‐dependent cell cycle promotion in gastrointestinal stromal tumours (GISTs)
  809. Loss of heterozygosity of CDKN2A (p16INK4a) and RB1 tumor suppressor genes in testicular germ cell tumors
  810. Loss of p16 protein expression associated with methylation of the p16INK4a gene is a frequent finding in Hodgkin’s disease.
  811. Loss of p16INK4a expression and homozygous CDKN2A deletion are associated with worse outcome and younger age in thymic carcinomas
  812. Loss of p16INK4a expression correlates with decreased survival in pediatric osteosarcomas
  813. Loss of p16INK4a expression is associated with vascular endothelial growth factor expression in squamous cell carcinoma of the esophagus
  814. Loss of p16INK4a Function Rescues Cellular Senescence Induced by Telomere Dysfunction
  815. Loss of p16INK4a gene renders mice more susceptible to DMBA-induced mammary carcinogenesis
  816. Loss of p16INK4a results in increased glucocorticoid receptor activity during fibrosarcoma development
  817. Loss of p16INK4a stimulates aberrant mitochondrial biogenesis through a CDK4/Rb-independent pathway
  818. Loss of the hSNF5 gene concomitantly inactivates p21CIP/WAF1 and p16INK4a activity associated with replicative senescence in A204 rhabdoid tumor cells
  819. Loss of the p16INK4a and p15INK4b genes, as well as neighboring 9p21 markers, in sporadic melanoma
  820. Low frequency of p16INK4a alterations in insulinomas
  821. Low p16INK4a expression associated with high expression of cancer stem cell markers predicts poor prognosis in cervical cancer after radiotherapy
  822. Low p16INK4a Expression in Early Passage Human Prostate Basal Epithelial Cells Enables Immortalization by Telomerase Expression Alone
  823. Low prevalence of p53, p16INK4a and Ha‐ras tumour‐specific mutations in low‐graded actinic keratosis
  824. Lower expression of p14ARF and p16INK4a correlates with higher DNMT3B expression in human oesophageal squamous cell carcinomas
  825. Lower specific micronutrient intake in colorectal cancer patients with tumors presenting promoter hypermethylation in p16INK4a, p14ARF and hMLH1
  826. LRIG1‑2 and LMO7 immunoreactivity in vulvar squamous cell carcinoma: Association with prognosis in relation to HPV‑DNA and p16INK4a status
  827. Management of HPV-Related Cervical Disease: Role of p16INK4a Immunochemistry. Review of the Literature
  828. Mangiferin induces islet regeneration in aged mice through regulating p16INK4a
  829. Mechanisms Of Human Epithelial Cell Immortalization And p16INK4a Induced Telomere-independent Senescence
  830. Mechanisms of inactivation of p14ARF, p15INK4b, and p16INK4a genes in human esophageal squamous cell carcinoma
  831. Mechanisms of inactivation of the p16INK4a gene in leiomyosarcoma of soft tissue: decreased p16 expression correlates with promoter methylation and poor …
  832. Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21CIP1/WAF1 and p16INK4a in vascular endothelial cells
  833. Melanin Accumulation Accelerates Melanocyte Senescence by a Mechanism Involving p16INK4a/CDK4/pRB and E2F1
  834. Methionyl-tRNA synthetase (MRS) controls CDK4 stabiltiy in p16INK4a negative cancer
  835. Methylation and expression of gene p16INK4a and RB in breast carcinoma
  836. Methylation and expression of gene p16INK4a and RB in gastric carcinomas
  837. Methylation and expression of the p16INK4a tumor suppressor gene in multiple myeloma
  838. Methylation and messenger RNA expression of p15INK4b but not p16INK4a are independent risk factors for ovarian cancer
  839. Methylation and mRNA expression of the p15INK4b, p16INK4a, BRCA1 and hMLH1 genes in ovarian cancer
  840. Methylation of CpG islands of p16INK4a and cyclinD1 overexpression associated with progression of intraductal proliferative lesions of the breast
  841. Methylation of p16INK4a and mitotic arrest defective protein 2 (MAD2) genes in gastric marginal-zone B-cell lymphomas
  842. Methylation of p16INK4a in primary gynecologic malignancy
  843. Methylation of p16INK4a promoters occurs in vivo in histologically normal human mammary epithelia
  844. Methylation of specific CpG sites in the promoter region could significantly down‐regulate p16INK4a expression in gastric adenocarcinoma
  845. Methylation of the p16INK4a gene in multiple myeloma
  846. Methylation of the p16INK4a promoter is associated with malignant behavior in abdominal extra-adrenal paragangliomas but not pheochromocytomas
  847. Methylation of the p16INK4a tumor suppressor gene 5′-CpG island in breast cancer
  848. Methylation status analysis of cell cycle regulatory genes (p16INK4a, p15INK4B, p21Waf1/Cip1, p27Kip1 and p73) in natural killer cell disorders
  849. Methylation status of p14ARF and p16INK4a as detected in pancreatic secretions
  850. Methylation status of p14ARF, p15INK4b, and p16INK4a genes in human hepatocellular carcinoma
  851. Methylation status of p16INK4a in human papillomavirus-associated cancer of oral cavity and oropharynx in northeastern Thailand
  852. Methylation, LOH and mutational analysis of p16INK4a and p15INK4B genes in primary and metastatic melanoma: 322
  853. Microarray-based method for detecting methylation changes of p16INK4a gene 5′-CpG islands in gastric carcinomas
  854. MicroRNA miR‐24 promotes cell proliferation by targeting the CDKs inhibitors p27Kip1 and p16INK4a
  855. MMP-9 short interfering RNA induced senescence resulting in inhibition of medulloblastoma growth via p16INK4a and mitogen-activated protein kinase pathway
  856. Modeling ASXL1 mutation revealed impaired hematopoiesis caused by derepression of p16INK4a through aberrant PRC1-mediated histone modification
  857. Modeling ASXL1 mutation revealed myelodysplasia caused by derepression of p16INK4a through aberrant PRC1-mediated histone modification
  858. Modulation of cdk2, cyclin D1, p16INK4a, p21WAF and p27Kip1 expression in endothelial cells by TNF/IFN gamma.
  859. Modulation of p16INK4a activity by Hsp90, Cdc37 and CRM1 influences the progression of preneoplastic lesions in rats with different predisposition to liver cancer …
  860. Modulation of the expression of p16INK4a and p14ARF by hnRNP A1 and A2 RNA binding proteins: Implications for cellular senescence
  861. Molecular and functional alterations associated with repression of tumor suppressor p16INK4a during immortalization of human endothelial cells
  862. Molecular detection of TP53, Ki-Ras and p16INK4a promoter methylation in plasma of patients with colorectal cancer and its association with prognosis …
  863. Molecular features of primary mediastinal B‐cell lymphoma: involvement of p16INK4a, p53 and c‐myc
  864. Molecular Genetic Analysis in B-cell Lymphomas: A Focus on the p53 Pathway and p16INK4a
  865. Molecular targeting of neuroblastoma with a novel p16INK4a transporter system
  866. Monitoring tumorigenesis and senescence in vivo with a p16INK4a-luciferase model
  867. Morphologic characteristics of p16INK4a-positive cells in cervical cytology samples.
  868. MOZ‐Mediated Repression of p16INK4a Is Critical for the Self‐Renewal of Neural and Hematopoietic Stem Cells
  869. MTHFR, MTR, and MTRR polymorphisms in relation to p16INK4a hypermethylation in mucosa of patients with colorectal cancer
  870. Multiple abnormalities of the p16INK4a-pRb regulatory pathway in cultured melanoma cells.
  871. Multiple mechanisms of p16INK4a inactivation in non-small cell lung cancer cell lines
  872. Multiple primary tumors as an indicator for p16INK4a germline mutations in pancreatic cancer patients?
  873. Mutant p53 collaborating with K-ras gene mutations and p16INK4a promoter methylation result in an age-related demographic shift in spontaneous lung tumor …
  874. Mutation of p16INK4a and p15INK4b genes of human bronchial epithelial cells malignantly transformed by cyclophosphamide and thiotepa
  875. Mutation profile of the p53, fhit, p16INK4a/p19ARF and H-ras genes in Indian breast carcinomas.
  876. Mutational analysis of genes p14ARF, p15INK4b, p16INK4a, and PTEN in human nervous system tumors
  877. Mutational analysis of N-ras, p53, CDKN2A (p16INK4a), p14ARF, CDK4, and MC1R genes in human dysplastic melanocytic naevi
  878. Mutational analysis of N-ras, p53, p16INK4a, p14ARF and CDK4 genes in primary human malignant mesotheliomas
  879. Mutational Analysis of p53, p21WAF1 and p16INK4a in Human Cervical Carcinomas
  880. Mutational analysis of the CDKN2 (MTS1/p16INK4a) gene in primary B-cell lymphomas
  881. Mutational analysis of the N-ras, p53, p16INK4a, CDK4, and MC1R genes in human congenital melanocytic naevi
  882. Mutational and methylation analysis of the cyclin‐dependent kinase 4 inhibitor (p16INK4a) gene in chronic lymphocytic leukemia
  883. Mutational effects on the p16INK4a tumor suppressor protein
  884. Mutations in Nf2 and p16INK4a synergize to promote meningioma development in mice
  885. Mutations in the CDKN2A ( p16INK4a ) gene in microdissected sporadic primary melanomas
  886. Mutations of the cell cycle regulatory genes p16INK4a and p21WAF1 and the metastasis-inducing gene S100A4 are infrequent and unrelated to p53 tumour …
  887. N-ethyl-N-nitrosourea (ENU)-Induced Meningiomatosis and Meningioma in p16INK4a/p19ARF Tumor Suppressor Gene-Deficient Mice
  888. N-ras oncogene–induced gene expression in human hematopoietic progenitor cells: Upregulation of p16INK4a and p21CIP1/WAF1 correlates with myeloid …
  889. Nano polythionine-based electrochemiluminescence biosensor for detection of the p16INK4a gene using RuAg@ AuNPs core-shell nanocomposites as DNA labels
  890. Natural History of Meningioma Development in Mice Reveals: A Synergy of Nf2 and p16INK4a Mutations
  891. No metastatic cervical adenocarcinomas in a series of p16INK4a-positive mucinous or endometrioid advanced ovarian carcinomas: an analysis of the AGO Ovarian …
  892. No p16INK4a/CDKN2/MTS1 mutations independent of p53 status in soft tissue sarcomas
  893. Nuclear p16INK4a expression predicts enhanced radiation response in head and neck cancers
  894. Obesity and p16INK4a downregulation activate breast adipocytes and promote their protumorigenicity
  895. Obesity-induced destabilization of p16INK4a promotes the procarcinogenic effects of breast stromal adipocytes through miR-141/miR-146b-5p-dependent inhibition of …
  896. Obligate roles for p16INK4a and p19Arf-p53 in the suppression of murine pancreatic neoplasia
  897. Oncogene-induced senescence does not require the p16INK4a or p14ARF melanoma tumor suppressors
  898. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
  899. OP235: A comparative study of p16INK4a immunohistochemical expression in oral and oropharyngeal sccs
  900. Oval cell proliferation in p16INK4a expressing mouse liver is triggered by chronic growth stimuli
  901. Over-expression of CDKIs p15INK4b, p16INK4a and p21CIP1/WAF1 genes mediate growth arrest in human osteosarcoma cell lines.
  902. Over‐expression of polycomb group protein EZH2 relates to decreased expression of p16INK4a in cholangiocarcinogenesis in hepatolithiasis
  903. Overexpression of p16INK4a and p14ARF in haematological malignancies
  904. Overexpression of p16INK4a as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri
  905. Overexpression of p16INK4a as an indicator for human papillomavirus oncogenic activity in cervical squamous neoplasia
  906. Overexpression of p16INK4a correlates with high expression of p73 in breast carcinomas
  907. Overexpression of p16INK4a in liquid‐based specimens (SurePath™) as marker of cervical dysplasia and neoplasia
  908. Overexpression of p16INK4a in Merkel cell carcinoma
  909. Overexpression of p16INK4a in urothelial carcinoma in situ is a marker for MAPK-mediated epithelial-mesenchymal transition but is not related to human …
  910. Overexpression of p16INK4a regulates the Wnt/β‑catenin signaling pathway in pancreatic cancer cells
  911. Overexpression of p16INK4a serves as prognostic marker in squamous cell vulvar cancer patients treated with radiotherapy irrespective of HPV-status
  912. Overexpression of the cell cycle inhibitor p16INK4a in high-grade prostatic intraepithelial neoplasia predicts early relapse in prostate cancer patients
  913. Overexpression of the Cell Cycle Inhibitor p16INK4a Promotes a Prothrombotic Phenotype Following Vascular Injury in Mice
  914. P‐22 p16INK4a AS A MARKER FOR CERVICAL DYSKARYOSIS IN THINPREP® LIQUID BASED CYTOLOGY SAMPLES
  915. P1-004: Role of cytology accompanied by the study of the occurrence of p16INK4a and O6-methylguanine-DNA transferase (MGMT) promoter methylation in the cells …
  916. p14ARF and p16INK4a promoter methylation in ulcerative colitis-related carcinogenesis
  917. p14ARF and p16INK4a, two products of the same gene, are differently expressed in cervical intraepithelial neoplasia
  918. p14ARF methylation is independent of p16INK4a methylation and aberrant p53 expression in gastric cancer
  919. p14ARF, p15INK4b and p16INK4a Methylation Status in Chronic Myelogenous Leukemia
  920. p14ARF,p15INK4b, and p16INK4amethylation status in chronic myelogenous leukemia
  921. p14arf/p16INK4a and p15ink4b Gene Expression Profile by Real Time Quantitative PCR at Diagnosis Predicts for Clinical Outcome in Multiple Myeloma Patients.
  922. p15INK4b, p14ARF, and p16INK4a inactivation in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumors
  923. p16INK4a adenovirus-mediated gene therapy for human head and neck squamous cell cancer.
  924. p16INK4a alterations in chronic pancreatitis—indicator for high-risk lesions for pancreatic cancer
  925. p16INK4a and CDH13 hypermethylation in tumor and serum of non‐small cell lung cancer patients
  926. p16INK4a and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer
  927. p16INK4a and HPV L1 immunohistochemistry is helpful for estimating the behavior of low-grade dysplastic lesions of the cervix uteri
  928. p16INK4a and Ki-67 immunostaining on cell blocks from residual ThinPrep material is helpful in identifying significant preneoplastic cervical lesions
  929. p16INK4a and Ki-67 measurement predict progression of cervical low-grade squamous intraepithelial lesion
  930. p16INK4a and Ki67 expression in normal, dysplastic and neoplastic uterine cervical epithelium and human papillomavirus (HPV) infection
  931. p16INK4a and laminin-5γ2 chain expression during the progression of cervical neoplasia
  932. p16INK4a and low-grade cervical intraepithelial neoplasia. Diagnostic and therapeutic implications
  933. p16INK4a and MIB-1: An immunohistochemical expression in preneoplasia and neoplasia of the cervix
  934. p16INK4a and p14ARF expression pattern by immunohistochemistry in human papillomavirus-related cervical neoplasia
  935. p16INK4a and p14ARF gene promoter hypermethylation as prognostic biomarker in oral and oropharyngeal squamous cell carcinoma: a review
  936. p16INK4a and p14ARF methylation as a potential biomarker for human bladder cancer
  937. p16INK4a and p14ARF tumor suppressor genes are commonly inactivated in cutaneous squamous cell carcinoma
  938. p16INK4a and p14ARF Tumor Suppressor Pathways Are Deregulated in Malignant Rhabdoid Tumors
  939. p16INK4a and p15INK4B gene deletions in primary leukemias
  940. p16INK4a and p15INK4b gene promoter methylation in cervical cancer patients
  941. p16INK4a and p15INK4B in senescence, immortalization and cancer: Gene transfer by adenovirus vectors
  942. p16INK4a and p19Arf: terrible twins
  943. p16INK4a and p19INK4d mRNA expression in neuroglial tumours: correlation with Ki67 proliferation index.
  944. p16INK4a and p21Waf1/Cip1 expression correlates with clinical outcome in vulvar carcinomas
  945. p16INK4a and p53 deficiency cooperate in tumorigenesis
  946. p16INK4a and ProEx C Immunostains Facilitate Differential Diagnosis of Hyperchromatic Crowded Groups in Liquid-Based Papanicolaou Tests with Menstrual …
  947. p16INK4a and retinoic acid modulate rhoA and GFAP expression during induction of a stellate phenotype in U343 MG‐A astrocytoma cells
  948. p16INK4a and survivin: Diagnostic and prognostic markers in cervical intraepithelial neoplasia and cervical squamous cell carcinoma
  949. p16INK4a and the control of cellular proliferative life span
  950. p16INK4a as a complementary marker of high‐grade intraepithelial lesions of the uterine cervix. I: Experience with squamous lesions in 189 consecutive cervical …
  951. p16INK4a as a marker for cervical dyskaryosis: CIN and cGIN in cervical biopsies and ThinPrep™ smears
  952. p16INK4a as a progression/regression tumour marker in LSIL cervix lesions: our clinical experience
  953. p16INK4a as a proliferation marker unrelated to HPV expression in odontogenic cysts and tumors
  954. p16INK4a as a second effector of the telomere damage pathway
  955. p16INK4a as a surrogate biomarker for human papillomavirus‐associated oropharyngeal carcinoma: Consideration of some aspects
  956. p16INK4a as a tumor suppressor with therapeutic applicability
  957. p16INK4a as an adjunct marker in liquid‐based cervical cytology
  958. p16INK4a as an adjunct test in cervical cytology.
  959. p16INK4a as an adjunct test in liquid-based cytology.
  960. p16INK4a correlates to human papillomavirus presence, response to radiotherapy and clinical outcome in tonsillar carcinoma
  961. p16INK4a deficiency promotes IL-4–induced polarization and inhibits proinflammatory signaling in macrophages
  962. p16INK4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of …
  963. p16INK4a deletion switches emphysema to fibrosis in mouse
  964. p16INK4a down-regulation activates breast stromal adipocytes.
  965. p16INK4a downregulation is involved in immortalization of primary human prostate epithelial cells induced by telomerase
  966. p16INK4a enhances the migration and metastasis phenotype of hepatocellular carcinoma cells
  967. p16INK4a enhances the transcriptional and the apoptotic functions of p53 through DNA‐dependent interaction
  968. p16INK4a exerts an anti-inflammatory effect through accelerated IRAK1 degradation in macrophages
  969. p16INK4a exon 1 alpha knockout in mouse embryonic stem cells
  970. p16INK4a expression adenovirus vector to suppress pancreas cancer cell proliferation
  971. p16INK4a Expression Analysis as an Ancillary Tool for Cytologic Diagnosis of Urothelial Carcinoma
  972. p16INK4a expression and absence of activated B-RAF are independent predictors of chemosensitivity in melanoma tumors
  973. p16INK4a expression and breast cancer risk in women with atypical hyperplasia
  974. p16INK4a expression and clinicopathologic parameters in renal cell carcinoma
  975. p16INK4a Expression and immunologic aging in Chronic HIV infection
  976. p16INK4a expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions
  977. p16INK4a expression as a potential prognostic marker in cervical precancerous and cancerous lesions in Morocco
  978. p16INK4a expression as biomarker for HPV 16-related vulvar neoplasias
  979. p16INK4a expression begins early in human colon neoplasia and correlates inversely with markers of cell proliferation
  980. p16INK4a expression decreases during imiquimod treatment of anal intraepithelial neoplasia in human immunodeficiency virus‐infected men and correlates with the …
  981. p16INK4a Expression does not predict the outcome of cervical intraepithelial neoplasia grade 2
  982. p16INK4a expression in actinic keratosis and Bowen’s disease
  983. p16INK4a expression in basal-like breast carcinoma
  984. p16INK4a expression in benign and malignant melanocytic conjunctival lesions
  985. p16INK4a Expression in Cervical Lesions Correlates with Histologic Grading-a Tertiary Level Medical Facility Based Retrospective Study
  986. p16INK4a expression in cervical premalignant and malignant lesions
  987. p16INK4a expression in cytology of ascites and response to chemotherapy in advanced ovarian cancer
  988. p16INK4a expression in invasive vulvar squamous cell carcinoma
  989. p16INK4a expression in malignant melanomas with or without a contiguous naevus remnant: a clue to their divergent pathogenesis?
  990. p16INK4a expression in patients with penile cancer.
  991. p16INK4a Expression in Porokeratosis
  992. p16INK4a expression in squamous cell carcinomas of the vagina and the vulva in Tunisian women
  993. p16INK4a expression in undifferentiated carcinoma of the uterus does not exclude its endometrial origin
  994. p16INK4a expression is frequently decreased and associated with 9p21 loss of heterozygosity in sporadic melanoma
  995. p16INK4a expression is frequently increased in periorbital and ocular squamous lesions
  996. p16INK4a expression is increased through 12-lipoxygenase in high glucose-stimulated glomerular mesangial cells and type 2 diabetic glomeruli
  997. p16INK4a expression is related to grade of CIN and high-risk human papillomavirus but does not predict virus clearance after conization or disease outcome
  998. p16INK4a expression mediated by recombinant adenovirus can induce senescence of A549 cells
  999. p16INK4a expression, human papillomavirus, and survival in head and neck cancer
  1000. p16INK4a gene alterations are frequent in lesions of mycosis fungoides
  1001. p16INK4a Gene and Hematological Malignancies
  1002. p16INK4a gene homozygous deletions in human acute leukaemias with alterations of chromosome 9
  1003. p16INK4a Gene Inactivation by Deletions, Mutations, and Hypermethylation Is Associated With Transformed and Aggressive Variants of Non-Hodgkin’s Lymphomas
  1004. p16INK4a gene promoter hypermethylation in mucosa as a prognostic factor for patients with colorectal cancer
  1005. p16INK4a genetic and epigenetic profiles differ in relation to age and site in head and neck squamous cell carcinomas
  1006. p16INK4a Hypermethylation detected by fluorescent methylation-specific PCR in plasmas from non-small cell lung cancer
  1007. p16INK4a hypermethylation is associated with hepatitis virus infection, age, and gender in hepatocellular carcinoma
  1008. p16INK4a immunocytochemical analysis is an independent prognostic factor in childhood acute lymphoblastic leukemia
  1009. p16INK4a immunocytochemistry in liquid-based cervical cytology: Is it feasible for clinical use?
  1010. p16INK4a immunocytochemistry on cell blocks as an adjunct to cervical cytology: Potential reflex testing on specially prepared cell blocks from residual liquid …
  1011. p16INK4a immunocytochemistry versus human papillomavirus testing for triage of women with minor cytologic abnormalities A systematic review and meta‐analysis
  1012. p16INK4a immunocytochemistry/immunohistochemistry: need for scoring uniformization to be clinically useful in gynecological pathology
  1013. p16INK4a immunoexpression and HPV in situ hybridization signal patterns: potential markers of high-grade cervical intraepithelial neoplasia
  1014. p16INK4a immunoexpression profile in HPV-oral lesions from HIV-infected patients
  1015. p16INK4a immunoexpression: surrogate marker of high-risk HPV and high-grade cervical intraepithelial neoplasia
  1016. p16INK4a immunohistochemical and histopathologic study of Pap test cases interpreted as HSIL without CIN2-3 identification in subsequent cervical specimens
  1017. p16INK4a Immunohistochemical Overexpression in Premalignant and Malignant Oral Lesions Infected with Human Papillomavirus
  1018. p16INK4a immunohistochemical staining and predictive value for progression of cervical intraepithelial neoplasia grade 1: A prospective study in China
  1019. p16INK4a immunohistochemical staining may be helpful in distinguishing branchial cleft cysts from cystic squamous cell carcinomas originating in the oropharynx
  1020. p16INK4a Immunohistochemistry for Detection of Human Papilloma Virus-Associated Penile Squamous Cell Carcinoma is Superior to in-Situ Hybridization
  1021. p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia
  1022. p16INK4a immunohistochemistry improves the reproducibility of the histological diagnosis of cervical intraepithelial neoplasia in cone biopsies
  1023. p16INK4a Immunohistochemistry in Cervical Biopsy Specimens: A Systematic Review and Meta-Analysis of the Interobserver Agreement
  1024. p16INK4a immunohistochemistry is a promising biomarker to predict the outcome of low grade cervical intraepithelial neoplasia: comparison study with HPV …
  1025. p16INK4a immunohistochemistry is superior to HPV in situ hybridization for the detection of high-risk HPV in atypical squamous metaplasia
  1026. p16INK4a immunostaining as an alternative to histology review for reliable grading of cervical intraepithelial lesions
  1027. p16INK4a immunostaining but lack of human papilloma virus type 16 in cutaneous squamous cell carcinoma and basal cell carcinoma: a report from West Iran
  1028. p16INK4a immunostaining identifies occult CIN lesions in HPV-positive women
  1029. p16INK4a immunostaining in cytological and histological specimens from the uterine cervix: a systematic review and meta-analysis
  1030. p16INK4a immunostaining is a strong indicator for high‐risk‐HPV‐associated oropharyngeal carcinomas and dysplasias, but is unreliable to predict low‐risk‐HPV …
  1031. p16INK4a Impairs Homologous Recombination
  1032. p16INK4a impairs homologous recombination–mediated DNA repair in human papillomavirus–positive head and neck tumors
  1033. p16INK4a in cellular senescence
  1034. p16INK4a in Melanocyte Senescence and Differentiation
  1035. p16INK4a in oral squamous cell carcinomas—a correlation with biological behaviors: immunohistochemical and FISH analysis
  1036. p16INK4a in routine practice as a marker of cervical epithelial neoplasia
  1037. p16INK4a inactivation mechanisms in non-small-cell lung cancer patients occupationally exposed to asbestos
  1038. p16INK4a induces differentiation and apoptosis in erythroid lineage cells
  1039. p16INK4a induces senescence and inhibits EMT through microRNA‐141/microRNA‐146b‐5p‐dependent repression of AUF1
  1040. p16INK4a influences the aging phenotype in the living skin equivalent
  1041. p16INK4a inhibits histologic progression and angiogenic signaling in Min colon tumors
  1042. p16INK4a inhibits the pro‐metastatic potentials of osteosarcoma cells through targeting the ERK pathway and TGF‐β1
  1043. p16INK4a inhibits the proliferation of osteosarcoma cells through regulating the miR-146b-5p/TRAF6 pathway
  1044. p16INK4a interferes with Abelson virus transformation by enhancing apoptosis
  1045. p16INK4a is a marker of good prognosis for primary invasive penile squamous cell carcinoma: a multi-institutional study
  1046. p16INK4a is a prognostic marker in resected ductal pancreatic cancer: an analysis of p16INK4a, p53, MDM2, an Rb
  1047. p16INK4a is a robust in vivo biomarker of cellular aging in human skin
  1048. p16INK4a is a surrogate biomarker for a subset of human papilloma virus‐associated dysplasias of the uterine cervix as determined on the Pap smear
  1049. p16INK4a is a surrogate marker for high-risk and malignant cervical lesions in the presence of human papillomavirus
  1050. p16INK4a is a tumor autoantigen in HR-HPV induced cancers
  1051. p16INK4a is a useful marker for the diagnosis of adenocarcinoma of the cervix uteri and its precursors: an immunohistochemical study with immunocytochemical …
  1052. p16INK4a Is a β-Catenin Target Gene and Indicates Low Survival in Human Colorectal Tumors
  1053. p16INK4a is not a Reliable Screening Marker of HPV Infection in Esophageal Squamous Cell Carcinoma: Evidence from a Meta-Analysis
  1054. p16INK4a is Overexpressed in H. pylori‐Associated Gastritis and is Correlated with Increased Epithelial Apoptosis
  1055. p16INK4a is regularly expressed in Hodgkin’s disease: comparison with retinoblastoma, p53 and MDM2 protein status, and the presence of Epstein-Barr virus.
  1056. p16INK4a is required for cisplatin resistance in cervical carcinoma SiHa cells
  1057. p16INK4a is required for hSNF5 chromatin remodeler-induced cellular senescence in malignant rhabdoid tumor cells
  1058. p16INK4a is superior to high‐risk human papillomavirus testing in cervical cytology for the prediction of underlying high‐grade dysplasia
  1059. p16INK4a lesions are common, early abnormalities that undergo clonal expansion in Barrett’s metaplastic epithelium
  1060. p16INK4a loss and sensitivity in KSHV associated primary effusion lymphoma
  1061. p16INK4a mediates age-related changes in mesenchymal stem cells derived from human dental pulp through the DNA damage and stress response
  1062. p16INK4a mediates cyclin dependent kinase 4 and 6 inhibition in senescent prostatic epithelial cells
  1063. p16INK4a methylation in serum as a follow-up marker for recurrence of colorectal cancer
  1064. p16INK4a modulates p53 in primary human mammary epithelial cells
  1065. p16INK4a negatively regulates Leptin through miR-141 and miR-146b-5p in breast stromal adipocytes
  1066. p16INK4a or p19Arf loss contributes to Tal1-induced leukemogenesis in mice
  1067. p16INK4a over-expression sensitizes HPV (-) HNSCC to radiation through down-regulation of USP7
  1068. p16INK4a overexpression and human papillomavirus infection in small cell carcinoma of the uterine cervix
  1069. p16INK4a overexpression and p16/Ki‐67 dual labeling versus conventional urinary cytology in the evaluation of urothelial carcinoma
  1070. p16INK4a overexpression and survival in osteosarcoma patients: a meta analysis
  1071. p16INK4a overexpression as a predictor of survival in ocular surface squamous neoplasia
  1072. p16INK4a Overexpression in Cervical Biopsies Collected from Women with Normal and Equivocal Pap Smears
  1073. p16INK4a overexpression in precancerous and cancerous lesions of the uterine cervix in Tunisian women
  1074. p16INK4a overexpression independent of Human Papilloma Virus (HPV) infection in rare subtypes of endometrial carcinomas
  1075. p16INK4a Overexpression is Associated with Poor Clinical Outcome in Ovarian Carcinoma
  1076. p16INK4a overexpression is frequently detected in tumour‐free tonsil tissue without association with HPV
  1077. p16INK4a overexpression is not linked to oncogenic human papillomaviruses in patients with high‐grade urothelial cancer cells
  1078. p16INK4a overexpression predicts lymph node metastasis in cervical carcinomas
  1079. p16INK4a overexpression predicts translational active human papillomavirus infection in tonsillar cancer
  1080. p16INK4a Peptide mimetics identified via virtual screening
  1081. p16INK4a played a critical role in exacerbating acute tubular necrosis in acute kidney injury
  1082. p16INK4a point mutations and promoter hypermetylation in bronchial preneoplastic lesions.
  1083. p16INK4a polymorphism and ANRIL expression in human breast cancer
  1084. p16INK4a polymorphism: associations with tumour progression in patients with sporadic colorectal cancer
  1085. p16INK4a positive cells in human skin are indicative of local elastic fiber morphology, facial wrinkling, and perceived age
  1086. p16INK4a positively regulates cyclin D1 and E2F1 through negative control of AUF1
  1087. p16INK4a Positively Regulates p21WAF1 Expression by suppressing AUF1-dependent mRNA decay
  1088. p16INK4a prevents centrosome dysfunction and genomic instability in primary cells
  1089. p16INK4a prevents the activation of aged quiescent dentate gyrus stem cells by physical exercise
  1090. p16INK4a promoter hypermethylation in oral scrapings of oral squamous cell carcinoma risk patients
  1091. p16INK4a promoter hypermethylation is associated with invasiveness and prognosis of oral squamous cell carcinoma in an age-dependent manner
  1092. p16INK4a Promoter hypermethylation of non‐tumorous tissue adjacent to gastric cancer is correlated with glandular atrophy and chronic inflammation
  1093. p16INK4a promoter is hypermethylated at a high frequency in esophageal adenocarcinomas
  1094. p16INK4a promoter methylation and 9p21 allelic loss in colorectal carcinomas: relation with immunohistochemical p16INK4a expression and with tumor budding
  1095. p16INK4a promoter methylation and protein expression in breast fibroadenoma and carcinoma
  1096. p16INK4a promoter methylation facilitates p53 inactivation in oral squamous cell carcinoma in Taiwan.
  1097. p16INK4a promoter mutations are frequent in primary sclerosing cholangitis (PSC) and PSC-associated cholangiocarcinoma
  1098. p16INK4a Promotes Differentiation and Inhibits Apoptosis of JKB Acute Lymphoblastic Leukemia Cells
  1099. p16INK4a protein expression is associated with poor survival of the breast cancer patients after CMF chemotherapy
  1100. p16INK4a protein is a specific molecular biomarker of breast cancer
  1101. p16INK4a represses breast stromal fibroblasts migration/invasion and their VEGF-A-dependent promotion of angiogenesis through Akt inhibition
  1102. p16INK4a sensitizes human leukemia cells to FAS-and glucocorticoid-induced apoptosis via induction of BBC3/Puma and repression of MCL1 and BCL2
  1103. p16INK4a status and response to induction low-dose fractionated radiation in advanced head and neck cancer
  1104. p16INK4a subcellular expression patterns in colorectal adenocarcinoma, adenoma and non-neoplastic tissue samples
  1105. p16INK4a suppresses BRCA1-deficient mammary tumorigenesis
  1106. p16INK4a suppression by glucose restriction contributes to human cellular lifespan extension through SIRT1-mediated epigenetic and genetic mechanisms
  1107. p16INK4a suppression of lung adenocarcinoma by Bmi-1 in the presence of p38 activation
  1108. p16INK4a translation suppressed by miR-24
  1109. p16INK4a tumor suppressor function in lung cancer cells involves cyclin-dependent kinase 2 inhibition by Cip/Kip protein redistribution
  1110. p16INK4a tumor suppressor gene expression and CD3ϵ deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis
  1111. p16INK4a upregulation mediated by SIX6 defines retinal ganglion cell pathogenesis in glaucoma
  1112. p16INK4a upregulation mediated by TBK1 induces retinal ganglion cell senescence in ischemic injury
  1113. p16INK4a-A possible marker in HPV persistence screening
  1114. p16INK4a-Expressing Mesenchymal Stromal Cells Restore the Senescence-Clearance-Regeneration Sequence that is Impaired in Chronic Muscle Inflammation
  1115. p16INK4a-expressing mesenchymal stromal cells restore the senescence–clearance–regeneration sequence that is impaired in chronic muscle inflammation
  1116. p16INK4a-independence of Epstein–Barr virus-induced cell proliferation and virus latency
  1117. p16INK4a-PTEN, E-cadherin, Bcl-2 and Ki-67 expression in prostate cancer: Its relationship with the metastatic potential and known prognostic factors
  1118. p16INK4a‐induced senescence is disabled by melanoma‐associated mutations
  1119. p16INK4a‐mediated suppression of telomerase in normal and malignant human breast cells
  1120. p16INK4a–alterations in primary angiosarcoma of the liver
  1121. p16INK4a—Is the future of cervical cancer screening rosy?
  1122. p16INK4a, a senescence marker, influences tenofovir/emtricitabine metabolite disposition in HIV‐infected subjects
  1123. p16INK4a, a surrogate marker of HPV infection and prognosis for head and neck cancer, delays DNA damage repair and enhances radiation response
  1124. p16INK4a, a tumor suppressor protein with a subtle but efficient role
  1125. p16INK4a, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer
  1126. p16INK4a, NAD+, and Sestrins: New Targets for Combating Aging‐Related Chronic Illness?
  1127. p16INK4a, not only a G1 inhibitor?
  1128. p16INK4a, p53, EGFR expression and KRAS mutation status in squamous cell cancers of the anus: correlation with outcomes following chemo-radiotherapy
  1129. p16INK4a: a central player in cellular senescence and a promising aging biomarker in elderly cancer patients
  1130. p16INK4a: a potential diagnostic adjunct for prediction of high-grade cervical lesions in liquid-based cytology: with HPV testing and histological correlation
  1131. p16INK4a: A surrogate marker of high‐risk human papillomavirus infection in squamous cell carcinoma of the nasal vestibule
  1132. p16INK4a/CDKN2 expression and its relationship with oral squamous cell carcinoma is our current knowledge enough?
  1133. p16INK4a/exon 2 mutations in squamous cell carcinoma of the head and neck region
  1134. p16INK4a/KI-67 immunocytochemistry in improving the predictive value for high grade cervical intraepithelial (≥ CIN2) lesions in pap smear
  1135. p16INK4a/Ki‐67 co‐expression specifically identifies transformed cells in the head and neck region
  1136. p16INK4a/Ki‐67 dual labelling as a marker for the presence of high‐grade cancer cells or disease progression in urinary cytopathology
  1137. p16INK4a/p19Arf Involves Function of Age-related Pancreatic β Cells
  1138. p16INK4aexpression after chemotherapy in older women with early-stage breast cancer.
  1139. p21 is associated with cyclin D1, p16INK4a and pRb expression in resectable non-small cell lung cancer.
  1140. P3. 208 The infection with human papillomavirus (HPV) type 16 features greater chance to p16INK4a gene methylation in cervical lesions compared to other viral …
  1141. P32 Prospective study on human papillomavirus significance in oral dysplasias in association with clinical parameters and p16INK4a expression
  1142. p38 MAPK and JNK antagonistically control senescence and cytoplasmic p16INK4a expression in doxorubicin-treated endothelial progenitor cells
  1143. p53 and p16INK4a/p19Arf loss promotes different pancreatic tumor types from PYMT-expressing progenitor cells
  1144. p53 but not p16INK4a induces growth arrest in retinoblastoma-deficient hepatocellular carcinoma cells
  1145. p53 Deficiency leads to compensatory up-regulation of p16INK4a
  1146. P53, p15INK4B, p16INK4a and p57KIP2 mutations during the progression of chronic myeloid leukemia.
  1147. Padrão de metilação do gene p16INK4a e de infecções por HPV de alto risco acompanham a evolução de lesões cervicais
  1148. Paradoxical down-regulation of p16INK4a mRNA with advancing age in acute myeloid leukemia
  1149. PD‑L1 expression is associated with p16INK4a expression in non‑oropharyngeal head and neck squamous cell carcinoma
  1150. Pediatric histiocytic sarcoma clonally related to precursor B‐cell acute lymphoblastic leukemia with homozygous deletion of CDKN2A encoding p16INK4a
  1151. Performance of in silico tools for the evaluation of p16INK4a (CDKN2A) variants in CAGI
  1152. Performance of p16INK4a ELISA as a primary cervical cancer screening test among a large cohort of HIV-infected women in western Kenya: a 2-year cross …
  1153. Performance of p16INK4a immunocytochemistry as a marker of anal squamous intraepithelial lesions
  1154. Performance of p16INK4a-cytology, HPV mRNA, and HPV DNA testing to identify high grade cervical dysplasia in women with abnormal screening results
  1155. Phage display specific p16INK4a binding peptide for ex vivo cancer cells imaging
  1156. Phase I/IIa study of therapeutic p16INK4a vaccination in patients with HPV-associated cancers.
  1157. Phase I/IIa trial targeting p16INK4a by peptide vaccination in patients with human papillomavirus-associated cancer.
  1158. Pioglitazone promotes preadipocyte proliferation by downregulating p16INK4a
  1159. Piwil2 expressed in various stages of cervical neoplasia is a potential complementary marker for p16INK4a
  1160. Point mutations in TP53 but not in p15Ink4b and p16INK4a genes represent poor prognosis factors in acute adult T cell leukemia/lymphoma
  1161. Polymorphism of p16INK4a gene and rare mutation of p15INK4b gene exon2 in primary hepatocarcinoma
  1162. Polymorphisms in promoter sequences of MDM2, p53, and p16INK4a genes in normal Japanese individuals
  1163. Possible associations among expression of p14ARF, p16INK4a, p21WAF1/CIP1, p27KIP1, and p53 accumulation and the balance of apoptosis and cell …
  1164. Possible involvement of hMLH1, p16INK4a and PTEN in the malignant transformation of endometriosis
  1165. Poster 15: Disruption of the p16INK4a-CDK4-pRB Tumor Suppressor Pathway and Telomerase-Mediated Immortalization Is Sufficient to Initiate the Malignant …
  1166. Potential diagnostic use of p16INK4a, a new marker that correlates with dysplasia in oral squamoproliferative lesions
  1167. pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4a tumor suppressor gene
  1168. pRb, but not p107 or p130, is required for full induction of p16INK4a in human mammary epithelial cells
  1169. Predicting functional significance of cancer‐associated p16INK4a mutations in CDKN2A
  1170. Prediction of clinical outcome using p16INK4a immunocytochemical expression in low-grade squamous intraepithelial lesions and high-risk HPV-positive …
  1171. Predictive significance of the alterations of p16INK4a, p14ARF, p53, and proliferating cell nuclear antigen expression in the progression of cervical cancer
  1172. Predictive value of p16INK4a and Ki-67 immunohistochemical staining in expectant management of cervical intraepithelial neoplasia grade 2
  1173. Predictive value of the combined p16INK4a and Ki-67 Immunocytochemistry in low-grade squamous Intraepithelial lesions
  1174. Premature senescence of balding dermal papilla cells in vitro is associated with p16INK4a expression
  1175. Prevalence of aberrant methylation of p14ARF over p16INK4a in some human primary tumors
  1176. Prevalence of human papillomavirus DNA and p16INK4a in penile cancer and penile intraepithelial neoplasia: a systematic review and meta-analysis
  1177. Prevalence of human papillomavirus16 DNA and p16INK4a protein in oral squamous cell carcinoma: A systematic review and meta-analysis
  1178. Primary cilium-dependent and-independent Hedgehog signaling inhibits p16INK4a
  1179. Primary Squamous Cell Carcinoma of the Upper Genital Tract: Utility of p16INK4a Expression and HPV DNA Status in its Differential Diagnosis from Extended …
  1180. Primary squamous cell carcinoma of the vagina: human papillomavirus detection, p16INK4a overexpression and clinicopathological correlations
  1181. Pro-inflammatory effects of different MWCNTs dispersions in p16INK4a-deficient telomerase-expressing human keratinocytes but not in human SV-40 immortalized …
  1182. Proanthocyanidins reactivate silenced tumor suppressor genes p16INK4a and Cip1/p21 by reducing DNA methylation and increasing histone acetylation in human …
  1183. Procedure for immunocytochemical detection of p16INK4a antigen in thin-layer, liquid-based specimens.
  1184. Prognostic and predictive value of koilocytosis, expression of e6 hpv types 16/18, p16INK4a, p53 in locally advanced squamous cell carcinomas of oral cavity and …
  1185. Prognostic implications of cyclins (D1, E, A), cyclin‐dependent kinases (CDK2, CDK4) and tumor‐suppressor genes (pRb, p16INK4a) in childhood acute …
  1186. Prognostic markers of high-grade squamous intraepithelial lesions: the role of p16INK4a and high-risk human papillomavirus
  1187. Prognostic significance of expression patterns of c-erbB-2, p53, p16INK4a, p27KIP1, cyclin D1 and epidermal growth factor receptor in oesophageal adenocarcinoma …
  1188. Prognostic significance of high-risk human papillomavirus and p16INK4a in patients with esophageal squamous cell carcinoma
  1189. Prognostic significance of overexpressed p16INK4a in esophageal squamous cell carcinoma: a meta-analysis
  1190. Prognostic significance of overexpressed p16INK4a in patients with cervical cancer: a meta-analysis
  1191. Prognostic significance of p14ARF, p15INK4b, and p16INK4a inactivation in malignant peripheral nerve sheath tumors
  1192. Prognostic significance of p16INK4a alteration for Ewing sarcoma: A meta‐analysis
  1193. Prognostic significance of p16INK4a alteration in soft tissue sarcomas: A meta-analysis
  1194. Prognostic significance of p16INK4a alterations and 9p21 loss of heterozigosity in locally advanced laryngeal squamous cell carcinoma
  1195. Prognostic significance of p16INK4a and human papillomavirus in patients with oropharyngeal cancer treated on TROG 02.02 phase III trial
  1196. Prognostic significance of p16INK4a expression and integrated human papillomavirus oncogen transcripts in dysplastic lesions of the uterine cervix
  1197. Prognostic significance of p16INK4a hypermethylation in non-small cell lung cancer is evident by quantitative DNA methylation analysis
  1198. Prognostic significance of p16INK4a/p53 in Tunisian patients with breast carcinoma
  1199. Prognostic significance of p21WAF1/CIP1, p16INK4a and CD44s in tongue cancer
  1200. Prognostic significance of p27KIP1 expression in resected non–small cell lung cancers: Analysis in combination with expressions of p16INK4a, pRB, and p53
  1201. Prognostic value of overexpressed p16INK4a in vulvar cancer: a meta-analysis
  1202. Prognostic value of p16INK4a and p14ARF gene hypermethylation in human colon cancer
  1203. Prognostic value of p16INK4a as a marker of clinical evolution in patients with cervical intraepithelial neoplasia grade 3 (CIN 3) treated by cervical conization
  1204. Prognostic value of p16INK4a expression in lung adenocarcinoma.
  1205. Progression of actinic keratosis to squamous cell carcinoma of the skin correlates with deletion of the 9p21 region encoding the p16INK4a tumor suppressor
  1206. Promoter and histone methylation and p16INK4a gene expression in colon cancer
  1207. Promoter hypermethylation and quantitative expression analysis of CDKN2A (p14ARF and p16INK4a) gene in esophageal squamous cell carcinoma
  1208. Promoter hypermethylation of p16INK4a, E-cadherin, O6-MGMT, DAPK and FHIT in adenocarcinomas of the esophagus, esophagogastric junction and proximal …
  1209. Promoter hypermethylation of p16INK4a, p14ARF, CyclinD2 and Slit2 in serum and tumor DNA from breast cancer patients
  1210. Promoter Hypermethylation of Tumor-Suppressor Genes p16INK4a, RASSF1A, TIMP3, and PCQAP/MED15 in Salivary DNA as a Quadruple Biomarker Panel for Early …
  1211. Promoter hypermethylation: a common cause of reduced p16INK4a expression in uveal melanoma
  1212. Promoter methylation and loss of p16INK4a gene expression in head and neck cancer
  1213. Promoter methylation of p16INK4a, hMLH1, and MGMT in liquid-based cervical cytology samples compared with clinicopathological findings and HPV presence
  1214. Promoter methylation of p16INK4a, RASSF1A, and DAPK is frequent in salivary adenoid cystic carcinoma
  1215. Promoter methylation of p16INK4a, RASSF1A, and RAR2b genes in tumor DNA from patients with breast cancer (BC) in correlation with clinical recurrence.
  1216. Promoter methylations of p16INK4a and p14ARF genes in early and advanced gastric cancer. Correlations of the modes of their occurrence with histologic type
  1217. Prostaglandin E2 receptor 2 overexpression in squamous cell carcinoma of the lung correlates with p16INK4a methylation and an unfavorable prognosis
  1218. Protein expression of the tumor suppressors p16INK4a and p53 and disease progression in recurrent respiratory papillomatosis
  1219. PROTEIN p16INK4a IMMUNOHISTOCHEMICAL EXPRESSION IN ADENOCARCINOMA OF THE ESOPHAGUS
  1220. Proteomic analysis of p16INK4a‐binding proteins
  1221. PTEN controls β‐cell regeneration in aged mice by regulating cell cycle inhibitor p16INK4a
  1222. Pyrosequencing® assays to study promoter CpG site methylation of the O6-MGMT, hMLH1, p14ARF, p16INK4a, RASSF1A, and APC1A genes
  1223. Qualification of a p16INK4a immunohistochemistry (IHC) assay for determination of HPV status in archival squamous cell carcinoma of the head and neck (SCCHN) …
  1224. Qualitative Detection of p16INK4a Protein as a Surrogate Biomarker in Invasive Squamous Cell Carcinoma of the Cervix
  1225. Quantitative analysis of CDKN2A methylation, mRNA, and p16INK4a protein expression in children and adolescents with Burkitt lymphoma: Biological and clinical …
  1226. Quantitative analysis of tumor-derived methylated p16INK4a sequences in plasma, serum, and blood cells of hepatocellular carcinoma patients
  1227. Quantitative assessment of aberrant p16INK4a methylation in ovarian cancer: a meta-analysis based on literature and TCGA datasets
  1228. Quantitative evaluation of p16INK4a promoter methylation using pyrosequencing in de novo diffuse large B-cell lymphoma
  1229. Quercetin is able to demethylate the p16INK4a gene promoter
  1230. Radionuclides in cigarettes may lead to carcinogenesis via p16INK4a inactivation
  1231. RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4a, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell lung cancer …
  1232. Ratio of Expression of p16INK4a to p14ARF Correlates with the Progression of Non‐small Cell Lung Cancer
  1233. Rb and p16INK4a expression in resected non-small cell lung tumors
  1234. Re-establishment of the expression of p16INK4a in the p16INK4a deficient SCL-II cell line recovers the G1/S cell cycle arrest and influences the apoptotic response …
  1235. Re-expression of hSNF5/INI1/BAF47 in pediatric tumor cells leads to G 1 arrest associated with induction of p16INK4a and activation of RB
  1236. Re: Biologic and Biochemical Analyses of p16INK4a Mutations From Primary Tumors
  1237. Re: Oda et al. Frequent alteration of p16INK4a/p14ARF and p53 pathways in the round cell component of myxoid/round cell liposarcoma: p53 gene alterations and …
  1238. Reactivation of methylation-silenced tumor suppressor gene p16INK4a by nordihydroguaiaretic acid and its implication in G1 cell cycle arrest
  1239. Reactivation of tumor suppressor p16INK4a
  1240. Reactive oxygen species promotes cellular senescence in normal human epidermal keratinocytes through epigenetic regulation of p16INK4a
  1241. Real-time in vivo imaging of p16INK4a reveals cross talk with p53
  1242. Reappraisal Of The p16INK4a/Prb Pathway and Telomerase Activity, Markers Of Cell Activation and Aging, In Adult Acute Lymphoblastic Leukemia: A Graall Study
  1243. Recovery of function in osteoarthritic chondrocytes induced by p16INK4a-specific siRNA in vitro
  1244. Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16INK4a
  1245. Reduced levels of p15INK4b, p16INK4a, p21cip1 and p27kip1 in pancreatic carcinoma
  1246. Reducing CDK4/6‐p16INK4a interface. Computational alanine scanning of a peptide bound to CDK6 protein
  1247. Regulation effect of dihydroartemisinin on p16INK4a protein expression in human prostate cancer PC‐3 cells and its possible mechanism
  1248. Regulation of CDK7–Carboxyl-Terminal Domain Kinase Activity by the Tumor Suppressor p16INK4a Contributes to Cell Cycle Regulation
  1249. Regulation of cellular senescence and p16INK4a expression by Id1 and E47 proteins in human diploid fibroblast
  1250. Regulation of cyclin D1 and p16INK4a is critical for growth arrest during mammary involution
  1251. Regulation of p16INK4a and TGF-beta by DNA hydroxymethylation in glioblastoma multiforme
  1252. Regulation of p16INK4a, The Cyclin Dependent Kinase Inhibitor & the Tumor Suppressor
  1253. Regulatory Mechanisms of Tumor Suppressor p16INK4a and Their Relevance to Cancer
  1254. RELATION OF THE PATTERN OF p16INK4a EXPRESSION TO THE GRADE OF CERVICAL INTRAEPITHELIA NEOPLASIA.
  1255. Relationship among human papillomavirus infection, p16INK4a, p53 and NF-κB activation in penile cancer from northern Thailand
  1256. Relationship between alterations of p16INK4a and p14ARF genes of CDKN2A locus and gastric carcinogenesis
  1257. Relationship between epidermal growth factor receptor status, p16INK4a, and outcome in head and neck squamous cell carcinoma
  1258. Relationship between expression and methylation status of p16INK4a and the proliferative activity of different areas’ tumour cells in human colorectal cancer
  1259. Reproducibility of p16INK4a Biomarker Levels, as Measured by ELISA, Among HIV-Positive Women in Western Kenya With Normal Cervical Exams During a 12 …
  1260. Requirements for cell cycle arrest by p16INK4a
  1261. Resistance of primary cultured mouse hepatic tumor cells to cellular senescence despite expression of p16INK4a, p19Arf, p53, and p21Waf1/Cip1
  1262. Response to the methylation inhibitor dihydro-5-azacytidine in mesothelioma is not associated with methylation of p16INK4a: results of cancer and leukemia …
  1263. Response: Re: Biologic and Biochemical Analyses of p16INK4a Mutations From Primary Tumors
  1264. Retinoic acid extends the in vitro life span of normal human oral keratinocytes by decreasing p16INK4a expression and maintaining telomerase activity
  1265. Retroviral transfer of the p16INK4a cDNA inhibits C6 glioma formation in Wistar rats
  1266. Retrovirus-mediated p16INK4a gene therapy for human hepatocellular carcinoma
  1267. Reversal of hypermethylation and reactivation of p16INK4a, RARβ, and MGMT genes by genistein and other isoflavones from soy
  1268. Reversible cell cycle inhibition and premature aging features imposed by conditional expression of p16INK4a
  1269. Role and epigenetic regulation of p16INK4a-MMP-1 axis in OA-associated senescence-like phenotype and hypertrophy of chondrocytes
  1270. Role for p16INK4a in progression of gastrointestinal stromal tumors of the stomach: alteration of p16INK4a network members
  1271. Role of HPV-16 in pathogenesis of oral epithelial dysplasia and oral squamous cell carcinoma and correlation of p16INK4a expression in HPV-16 positive cases …
  1272. Role of HSP90, CDC37, and CRM1 as modulators of p16INK4a activity in rat liver carcinogenesis and human liver cancer
  1273. Role of p16INK4a and BMI-1 in oxidative stress-induced premature senescence in human dental pulp stem cells
  1274. Role of p16INK4a as a biomarker in liquid-based cervical cytology screening
  1275. Role of p16INK4a Cytology Testing as an Adjunct to Enhance the Diagnostic Specificity and Accuracy in Human Papillomavirus-Positive Women within an Organized …
  1276. Role of p16INK4a in the inhibition of DNA synthesis stimulated by HGF or EGF in primary cultured rat hepatocytes
  1277. ROLE OF p16INK4a, hTERT AND K-ras IN EARLY DETECTION OF GYNECOLOGICAL MALIGNANCIES
  1278. Role of quantitative p16INK4a mRNA assay and digital reading of p16INK4a immunostained sections in diagnosis of cervical intraepithelial neoplasia
  1279. Role of senescence marker p16INK4a measured in peripheral blood T-lymphocytes in predicting length of hospital stay after coronary artery bypass surgery in older …
  1280. Role of the alternative INK4A proteins in human keratinocyte senescence: evidence for the specific inactivation of p16INK4a upon immortalization
  1281. Roles of p15Ink4b and p16INK4a in myeloid differentiation and RUNX1-ETO-associated acute myeloid leukemia
  1282. S-phase lengthening induced by p16INK4a overexpression in malignant cells with wild-type pRb and p53
  1283. Screening for Human Papillomavirus in Basaloid Squamous Carcinoma: Utility of p16INK4a, CISH, and PCR
  1284. Selective loss of resistant alleles at p15INK4B and p16INK4a genes in chemically-induced rat tongue cancers
  1285. Senescence delay of human diploid fibroblast induced by anti-sense p16INK4a expression
  1286. Sexual behaviour, HPV status and p16INK4a expression in oropharyngeal and oral cavity squamous cell carcinomas: a case–case comparison study
  1287. Shelterin dysfunction and p16INK4a-mediated growth inhibition in HIV-1-specific CD8 T cells
  1288. Shortening of human cell life span by induction of p16INK4a through the platelet‐derived growth factor receptor β
  1289. Significance of immunohistochemical expression of p16INK4a in the differentiation of inflammatory and preneoplastic cervical lesions
  1290. Significance of p16INK4a hypermethylation gene in primary head/neck and colorectal tumors: it is a specific tissue event? Results of a 3-year GOIM (Gruppo …
  1291. Significance of the expression of EMMPRIN, CD24 and p16INK4a promoter methylation in gastric carcinoma
  1292. Significant role for p16INK4a in p53-independent telomere-directed senescence
  1293. Simulation of Different Truncated p16INK4a Forms and In Silico Study of Interaction with Cdk4
  1294. Single-Center Analysis of Human Papillomavirus Infection and p16INK4a Expression among Korean Patients with Penile Cancer
  1295. Single‐cell analysis of p16INK4a and p21WAF1 expression suggests distinct mechanisms of senescence in normal human and Li‐Fraumeni Syndrome fibroblasts
  1296. SM22α-induced activation of p16INK4a/retinoblastoma pathway promotes cellular senescence caused by a subclinical dose of γ-radiation and doxorubicin in HepG2 …
  1297. Specific allelic loss of p16INK4a tumor suppressor gene after weeks of iron-mediated oxidative damage during rat renal carcinogenesis
  1298. Stabilization of Cyclin-Dependent Kinase 4 by Methionyl-tRNA Synthetase in p16INK4a-Negative Cancer
  1299. Staining characteristics of p16INK4a: Is there a correlation with lesion grade or high‐risk human papilloma virus positivity?
  1300. Stathmin 1 and p16INK4a are sensitive adjunct biomarkers for serous tubal intraepithelial carcinoma
  1301. Status of p16INK4a and E-Cadherin Gene Promoter Methylation in Moroccan Patients With Cervical Carcinoma
  1302. Staying Young with p16INK4a
  1303. Stress-Induced Premature Senescence Promotes Proliferation by Activating the SENEX and p16INK4a/Retinoblastoma (Rb) Pathway in Diffuse Large B-Cell …
  1304. Structural Analysis of the Inhibition of Cdk4 and Cdk6 by p16INK4a through Molecular Dynamics Simulations
  1305. Structural Consequences of Tumor-Derived Mutations in p16INK4a Probed by Limited Proteolysis
  1306. Structure and function of mouse p16INK4a locus
  1307. Studies on the Expression of p16INK4a mRNA in Cervical Dysplasias
  1308. Study of p16INK4a expression in cervical intraepithelial lesions and cervi-cal carcinoma
  1309. STUDY OF REST AS A NEGATIVE REGULATOR OF p16INK4a
  1310. Subcellular re-distribution of F-actin in MCF7 cells upon inducible expression of CDKN2A/p16INK4a
  1311. Supplemental Data Significant Role for p16INK4a in p53-Independent Telomere-Directed Senescence
  1312. Supplemental Data Telomere Shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a
  1313. Suppressing p16INK4a and P14ARF pathways overcomes apoptosis in individualized human embryonic stem cells
  1314. SUPPRESSION OF ARTHRITIS BY ADENOVIRAL VECTOR MEDIATED p16INK4a GENE TRANSFER
  1315. Survey of p16INK4a immunohistochemistry in diagnosis of dysplastic changes in cervix
  1316. Sustained p16INK4a expression is required to protect against IR-induced lymphoma in mice
  1317. Systemic clearance of p16INK4a‐positive senescent cells mitigates age‐associated intervertebral disc degeneration
  1318. Systemic transduction of p16INK4a antitumor peptide inhibits lung metastasis of the MBT‑2 bladder tumor cell line in mice
  1319. Systemic transduction of p16INK4a antitumor peptide inhibits the growth of MBT-2 mouse bladder tumor cell line grafts
  1320. T-Cell p16INK4a Expression Increases Post-Transplant in Patients with Multiple Myeloma
  1321. Targeted inactivation of HDAC2 restores p16INK4a activity and exerts antitumor effects on human gastric cancer
  1322. Targeting p16INK4a in uterine serous carcinoma through inhibition of histone demethylation
  1323. Telomerase Induces Immortalization of Human Esophageal Keratinocytes Without p16INK4a Inactivation1 1 NIH grants R01-DK5337 (AKR), P01-DE12467 (AKR) …
  1324. Telomere dysfunction and inactivation of the p16INK4a/Rb pathway in pyothorax‐associated lymphoma
  1325. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21CIP1, but not p16INK4a
  1326. Telomere-driven karyotypic complexity concurs with p16INK4a inactivation in TP53-competent immortal endothelial cells
  1327. Tenofovir/emtricitabine metabolites and endogenous nucleotide exposures are associated with p16INK4a expression in subjects on combination therapy
  1328. The 5′-flanking region of the E1 α form of the murine p16INK4a (MTS1) gene
  1329. The 5′-untranslated region of p16INK4a melanoma tumor suppressor acts as a cellular IRES, controlling mRNA translation under hypoxia through YBX1 …
  1330. The absence of high-risk HPV combined with specific p53 and p16INK4a expression patterns points to the HPV-independent pathway as the causative agent for …
  1331. The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4a expression
  1332. The association of increased p14ARF/p16INK4a and p15INK4a gene expression with proliferative activity and the clinical course of multiple myeloma
  1333. The atr protein kinase controls UV-dependent upregulation of p16INK4a through inhibition of Skp2-related polyubiquitination/degradation
  1334. The basic helix–loop–helix transcription factor TAL1/SCL inhibits the expression of the p16INK4a and pTα genes
  1335. The Battle between Tumor Suppressors: Is Gene Therapy Using p16INK4a More Efficacious Than p53 for Treatment of Ovarian Carcinoma?: Commentary re: SC …
  1336. The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins
  1337. The cell cycle inhibitor p16INK4a sensitizes lymphoblastic leukemia cells to apoptosis by physiologic glucocorticoid levels
  1338. The Cell Cycle Regulators p16INK4a, P15INK4b and Cyclin D1: Relationship to Clinicopathological Parameters and Disease-free Survival in Laryngeal Carcinoma …
  1339. The clinical impact of using p16INK4a immunochemistry in cervical histopathology and cytology: An update of recent developments
  1340. The co-transfection of p16INK4a and p14ARF genes into human lung cancer cell line A549 and the effects on cell growth and chemosensitivity
  1341. The contrasting role of p16INK4a patterns of expression in neuroendocrine and non-neuroendocrine lung tumors: a comprehensive analysis with …
  1342. The COOH terminus of p18INK4C distinguishes function from p16INK4a
  1343. The cyclin-dependent kinase inhibitor p16INK4a physically interacts with transcription factor Sp1 and cyclin-dependent kinase 4 to transactivate microRNA-141 and …
  1344. The effect of acute dichlorodiphenyltrichloroethane exposure on hypermethylation status and down‐regulation of p53 and p16INK4a genes in rat liver
  1345. The effects of chronic and acute toxicological exposures on the expression of the tumor suppressor p16INK4a
  1346. The effects of fucodian on senescence are controlled by the p16INK4a-pRb and p14Arf-p53 pathways in hepatocellular carcinoma and hepatic cell lines
  1347. The effects of short-term hypoxia on human mesenchymal stem cell proliferation, viability and p16INK4a mRNA expression: Investigation using a simple …
  1348. The effects of transferring tumor suppressor gene p16INK4a to p16INK4a-deleted cancer cells
  1349. The evaluation of p16INK4a immunoexpression/immunostaining and human papillomavirus DNA test in cervical liquid-based cytological samples
  1350. The expression and significance of insulin like growth factor-II mRNA binding protein 3 (IMP3) and p16INK4a in adenocarcinoma of the uterine cervix
  1351. The expression and significance of PCNA, CDK4 and p16INK4a in nonneoplastic epithelial disorders of vulvar
  1352. The Expression of E6 HPV, P53 nd p16INK4a at Well, Moderately, and Poorly Differentiated Cervical Adenocarcinoma
  1353. THE EXPRESSION OF p16INK4a IN ODONTOGENIC CYSTS AND TUMORS
  1354. The expression of p16INK4a tumor suppressor is upregulated by human cytomegalovirus infection and required for optimal viral replication
  1355. The expression of p16INK4a, the product of a tumor suppressor gene for melanoma, is upregulated in human melanocytes by UVB irradiation
  1356. The expression of Topoisomerase Ⅱ and p16INK4a in cervical intraepithelial neoplasia after infection of high-risk type human papillomavirus and their value for …
  1357. The Expressions of Cell Cycle Regulatory Proteins p14arf, p16INK4a and p53 in Human Endometrial Carcinoma [J]
  1358. The homeoprotein SIX1 controls cellular senescence through the regulation of p16INK4a and differentiation-related genes
  1359. The human p19ARF protein encoded by the β transcript of the p16INK4a gene is frequently lost in small cell lung cancer
  1360. The induction of H3K9 methylation by PIWIL4 at the p16INK4a locus
  1361. The influence of anthracosis and p16INK4a gene aberrant methylation on small-sized pulmonary adenocarcinoma
  1362. The Influence of PDL 585 nm Laser on the Expression of p16INK4a of Human Fibroblast in Vitro [J]
  1363. The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss
  1364. The inhibition of T-cells proliferation by mouse mesenchymal stem cells through the induction of p16INK4a-cyclin D1/cdk4 and p21waf1, p27kip1-cyclin E/cdk2 …
  1365. The inhibitor of cyclin-dependent kinase 4a/alternative reading frame (INK4a/ARF) locus encoded proteins p16INK4a and p19ARF repress cyclin D1 transcription …
  1366. The inhibitory effect of adenovirus-mediated p16INK4a gene transfer on the proliferation of lung cancer cell line.
  1367. The invasion front of human colorectal adenocarcinomas shows co-localization of nuclear β-catenin, cyclin D1, and p16INK4a and is a region of low proliferation
  1368. The loss of p16INK4a function is essential for Werner Syndrome mouse embryo fibroblasts to escape from senescence
  1369. The lymphoma-associated NPM-ALK oncogene elicits a p16INK4a/pRb-dependent tumor-suppressive pathway
  1370. The meaning of p16INK4a expression in tumors: Functional significance, clinical associations and future developments
  1371. The melanoma‐associated 24 base pair duplication in p16INK4a is functionally impaired
  1372. The methylation pattern of p16INK4a gene promoter in psoriatic epidermis and its clinical significance
  1373. The methylation profile of p16INK4a in alt tumor cells derived from werner syndrome mouse model
  1374. The methylation status and protein expression of CDH1, p16INK4a, and fragile histidine triad in nonsmall cell lung carcinoma: Epigenetic silencing, clinical features …
  1375. The methylthioadenosine phosphorylase gene is frequently co‐deleted with the p16INK4a gene in acute type adult T‐cell leukemia
  1376. The molecular balancing act of p16INK4a in cancer and aging
  1377. The negative predictive value of p16INK4a to assess the outcome of cervical intraepithelial neoplasia 1 in the uterine cervix
  1378. The number of p16INK4a positive cells in human skin reflects biological age
  1379. The OGF–OGFr Axis Utilizes the p16INK4a and p21WAF1/CIP1 Pathways to Restrict Normal Cell Proliferation
  1380. The overexpression of histone deacetylase 1 and its relationship with p16INK4a gene hypermethylation in pulmonary squamous cell carcinoma and …
  1381. The p15INK4b/p16INK4a/RB1 Pathway Is Frequently Deregulated in Human Pituitary Adenomas
  1382. The p16INK4a Expression in Stomach Cancer, Colon Cancer and Hepatoma Cell Lines
  1383. The p16INK4a mRNA transcripts estimation in cervical smear with different degrees of cervical dysplasia
  1384. The p16INK4a protein: a cytological marker for detecting high grade intraepithelial neoplasia of the uterine cervix
  1385. The p16INK4a tumor suppressor regulates cellular oxidative stress
  1386. The p16INK4a tumour suppressor protein inhibits αvβ3 integrin‐mediated cell spreading on vitronectin by blocking PKC‐dependent localization of αvβ3 to focal …
  1387. The p16INK4a-RB pathway: molecular link between cellular senescence and tumor suppression
  1388. The p16INK4a/pRb pathway and telomerase activity define a subgroup of Ph+ adult Acute Lymphoblastic Leukemia associated with inferior outcome
  1389. The PAX3-FKHR fusion gene of rhabdomyosarcoma cooperates with loss of p16INK4a to promote bypass of cellular senescence
  1390. The PPARα/p16INK4a Pathway Inhibits Vascular Smooth Muscle Cell Proliferation by Repressing Cell Cycle–Dependent Telomerase Activation
  1391. The Predictive Value of p16INK4a and Hybrid Capture 2 Human Papillomavirus Testing for High-Grade Cervical Intraepithelial Neoplasia
  1392. The predictive value of p16INK4a immunocytochemistry as an adjunctive test for borderline cervical cytology
  1393. The presence of high‐risk HPV combined with specific p53 and p16INK4a expression patterns points to high‐risk HPV as the main causative agent for …
  1394. The presence of methylation of the p16INK4a gene and human papillomavirus in high-grade cervical squamous intraepithelial lesions
  1395. The prevalence and clinicopathologic correlate of p16INK4a, retinoblastoma and p53 immunoreactivity in locally advanced urinary bladder cancer
  1396. The prognostic significance of p16INK4a/p14ARF and p15INK4b deletions in adult acute lymphoblastic leukemia
  1397. The prognostic significance of p16INK4a/p14ARF locus deletion and MDM‐2 protein expression in adult acute myelogenous leukemia
  1398. The reduced expression and aberrant methylation of p16INK4a in chromate workers with lung cancer
  1399. The retinoblastoma protein/p16INK4a pathway but not p53 is disrupted by human papillomavirus in penile squamous cell carcinoma
  1400. The role and regulation of tumor suppressor p16INK4a in intestinal neoplasia
  1401. The role of biomarkers (p16INK4a and Ki-67) in cervical cancer screening: An appraisal
  1402. The role of deeper levels and ancillary studies (p16INK4a and ProExC) in reducing the discordance rate of Papanicolaou findings of high‐grade squamous …
  1403. The Role of p16INK4a Expression in the Age-related Risk of Venous Thromboembolism
  1404. The role of p16INK4a pathway in human epidermal stem cell self-renewal, aging and cancer
  1405. The role of polyhomeotic in polycomb group-mediated regulation of the tumour suppressor p16INK4a
  1406. The rs11515 polymorphism is more frequent and associated with aggressive breast tumors with increased ANRIL and decreased p16INK4a expression
  1407. The Sensitivity and Specificity of p16INK4a Cytology vs HPV Testing for Detecting High-Grade Cervical Disease in the Triage of ASC-US and LSIL Pap Cytology …
  1408. The significance of liquid-based cytology test in combination with p16INK4a and cyclin E in diagnosis of cervical intraepithelial neoplasia.
  1409. The significance of p16INK4a in cell defences against transformation
  1410. The Significance of p16INK4a protein Expression in the Cervical Cancer
  1411. The specific role of pRb in p16INK4a-mediated arrest of normal and malignant human breast cells
  1412. The specificity and patterns of staining in human cells and tissues of p16INK4a antibodies demonstrate variant antigen binding
  1413. The study of CDKN2/p16INK4a mutation in human breast cancer
  1414. The thymine DNA glycosylase MBD4 represses transcription and is associated with methylated p16INK4a and hMLH1 genes
  1415. The triage of low-grade cytological abnormalities by the immunocytological expression of cyclin-dependent kinase inhibitor p16INK4a versus Human Papillomavirus …
  1416. The tumor suppressor p33ING1b upregulates p16INK4a expression and induces cellular senescence
  1417. The tumor suppressor protein p16INK4a
  1418. The Tumor Suppressor Protein p16INK4a and the Human Papillomavirus Oncoprotein-58 E7 Are Naturally Occurring Lysine-less Proteins That Are Degraded by the …
  1419. The tumour suppressor CDKN2A/p16INK4a regulates adipogenesis and bone marrow-dependent development of perivascular adipose tissue
  1420. The use of p16INK4a as an adjunct to the interpretation of cervical biopsies
  1421. The use of p16INK4a immunocytochemistry in “Atypical squamous cells which cannot exclude HSIL” compared with “Atypical squamous cells of undetermined …
  1422. The use of p16INK4a in further defining atypical squamous cells cannot exclude a high grade lesion on cervical cytology (ASC-H): results of a pilot study
  1423. The use of recombinant pseudotype virus-like particles harbouring inserted target antigen to generate antibodies against cellular marker p16INK4a
  1424. The usefulness of p16INK4a in cytological screening of cervical carcinoma
  1425. The utility of p16INK4a and Ki-67 as a conjunctive tool in uterine cervical lesions
  1426. The utility of p16INK4a and Ki‐67 staining on cell blocks prepared from residual thin‐layer cervicovaginal material
  1427. The utility of p16INK4a expression in uterine cervical biopsies reported negative and positive for dysplasia at Kenyatta National Hospital, Nairobi, Kenya
  1428. The Utility of p16INK4a in Discriminating Between Cervical Intraepithelial Neoplasia 1 and Nonneoplastic Equivocal Lesions of the Cervix
  1429. The utility of ThinPrep cytology and immunohistochemical staining of p16INK4a, Ki-67, and p63 in the assessment of cervical intraepithelial neoplasia (dysplasia)
  1430. The value of p16INK4a expression by fluorescence in situ hybridization in triage for high risk HPV positive in cervical cancer screening
  1431. Thin HSIL of the cervix: detecting a variant of high-grade squamous intraepithelial lesions with a p16INK4a antibody
  1432. Three-tiered score for Ki-67 and p16INK4a improves accuracy and reproducibility of grading CIN lesions
  1433. TMEM45A, SERPINB5 and p16INK4a transcript levels are predictive for development of high-grade cervical lesions
  1434. TP53 and p16INK4a mutations in adult-T cell leukemia/lymphoma (ATL) in Bahia (Brazil)
  1435. TP53 and p16INK4a, but not H‐KI‐Ras, are involved in tumorigenesis and progression of pleomorphic adenomas
  1436. TP53, p14ARF, p16INK4a and H‐ras gene molecular analysis in intestinal‐type adenocarcinoma of the nasal cavity and paranasal sinuses
  1437. Transcriptional regulation of the CDK inhibitor p16INK4a gene by a novel pRb‐associated repressor, RBAR1
  1438. Transduced p16INK4a peptides inhibit hypophosphorylation of the retinoblastoma protein and cell cycle progression prior to activation of Cdk2 complexes in late G1
  1439. Transgenic expression of the p16INK4a cyclin-dependent kinase inhibitor leads to enhanced apoptosis and differentiation arrest of CD4− CD8− immature thymocytes
  1440. Transient induction of the p16INK4a/pRb pathway leads to stable changes in telomerase in normal and malignant breast epithelial cells
  1441. Transition of cervical carcinoma in situ to invasive cancer: Role of p16INK4a expression in progression and in recurrence
  1442. Transoral robotic surgery and adjuvant therapy for oropharyngeal carcinomas and the influence of p16INK4a on treatment outcomes
  1443. Triage of women with ASCUS and LSIL cytology Use of qualitative assessment of p16INK4a positive cells to identify patients with high‐grade cervical intraepithelial …
  1444. TSG101 promotes SUMOylation of HDAC1 that represses p16INK4a expression
  1445. TUMOR SUPPRESSING FUNCTIONS OF p16INK4a-A REVIEW
  1446. Tumor Suppression for ARFicionados: The Relative Contributions of p16INK4a and p14ARF in Melanoma
  1447. Tumor suppressor and aging biomarker p16INK4a induces cellular senescence without the associated inflammatory secretory phenotype
  1448. Tumor suppressor INK4: Comparisons of conformational properties between p16INK4a and p18INK4C
  1449. Tumor suppressor INK4: determination of the solution structure of p18INK4C and demonstration of the functional significance of loops in p18INK4C and p16INK4a
  1450. Tumor suppressor p16INK4a − modulator of glycomic profile and galectin‐1 expression to increase susceptibility to carbohydrate‐dependent induction of anoikis in …
  1451. Tumor suppressor p16INK4a controls oncogenic K‐Ras function in human pancreatic cancer cells
  1452. Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenes
  1453. Tumor suppressor p16INK4a inhibits cancer cell growth by downregulating eEF1A2 through a direct interaction
  1454. Tumor suppressor p16INK4a is necessary for survival of cervical carcinoma cell lines
  1455. Tumor suppressor p16INK4a regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells
  1456. Tumor suppressor p16INK4a regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells.
  1457. Tumor Suppressor p16INK4a: Structural Characterization of Wild-Type and Mutant Proteins by NMR and Circular Dichroism
  1458. Tumor suppressor p16INK4a: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4
  1459. Tumor suppressor p16INK4a: Downregulation of galectin‐3, an endogenous competitor of the pro‐anoikis effector galectin‐1, in a pancreatic carcinoma model
  1460. Tumor suppressor p16INK4a/Cdkn2a alterations in 7, 12‐dimethylbenz(a)anthracene (DMBA)‐induced hamster cheek pouch tumors
  1461. Tumour suppressor p16INK4a – anoikis‐favouring decrease in N/O‐glycan/cell surface sialylation by down‐regulation of enzymes in sialic acid biosynthesis in …
  1462. Two mechanisms underlying the loss of p16INK4a function are associated with distinct tumorigenic consequences for WS MEFs escaping from senescence
  1463. Ultrasensitive electrochemical immunosensor based on dual signal amplification process for p16INK4a cervical cancer detection in clinical samples
  1464. Understanding the Early Events in Breast Carcinogenesis by Inactivating p16INK4a in Primary Human Mammary Epithelial Cells
  1465. Unfolding transition state and intermediates of the tumor suppressor p16INK4a investigated by molecular dynamics simulations
  1466. Up-regulated expression of E2F2 is necessary for p16INK4a-induced cartilage injury
  1467. Up-regulation of p27Kip1, p21WAF1/Cip1 and p16INK4a is associated with, but not sufficient for, induction of squamous differentiation
  1468. Up-regulation of survivin during immortalization of human myofibroblasts is linked to repression of tumor suppressor p16INK4a protein and confers resistance to …
  1469. Upregulation of Anti-Oxidant Signal Pathway and Cytokine Release by Inhibition of p16INK4a in Aging Human Cardiac Progenitor Cells
  1470. Upregulation of p16INK4a promotes cellular senescence of bone marrow-derived mesenchymal stem cells from systemic lupus erythematosus patients
  1471. Upregulation of survivin during immortalization is linked to repression of p16INK4a and confers resistance to oxidative stress
  1472. Uropathogenic E. coli infection provokes epigenetic downregulation of CDKN2A (p16INK4a) in uroepithelial cells
  1473. Use of Cytology, E6/E7 mRNA, and p16INK4a–Ki-67 to Define the Management of Human Papillomavirus (HPV)–Positive Women in Cervical Cancer Screening
  1474. Usefulness of CINtec® PLUS p16INK4a/Ki-67 double-staining in cytological screening of cervical cancer
  1475. Utility of p16INK4a Immunocytochemistry in Liquid-Based Cytology Specimens from Women Treated for High-Grade Squamous Intraepithelial Lesions
  1476. Utility of p16INK4a, CEA, Ki67, P53 and ER/PR in the differential diagnosis of benign, premalignant, and malignant glandular lesions of the uterine cervix and their …
  1477. V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a
  1478. Validation of p16INK4a as a marker of oncogenic human papillomavirus infection in cervical biopsies from a population-based cohort in Costa Rica
  1479. Valproic acid induces apoptosis, p16INK4a upregulation and sensitization to chemotherapy in human melanoma cells
  1480. Value of p16INK4a and RASSF1A promoter hypermethylation in prognosis of patients with resectable non–small cell lung cancer
  1481. Value of p16INK4a as a marker of progression/regression in cervical intraepithelial neoplasia grade 1
  1482. Value of p16INK4a in the diagnosis of low‐grade urothelial carcinoma of the urinary bladder in urinary cytology
  1483. Value of p16INK4a in the pathology of invasive penile squamous cell carcinomas: a report of 202 cases
  1484. VentX trans-activates p53 and p16INK4a to regulate cellular senescence
  1485. Which test is a better strategy to determine the outcome of atypical glandular cell-categorized Pap smears? Immunocytochemical p16INK4a expression or human …
  1486. Widespread cell cycle inhibition and features of premature aging in mice with conditional expression of p16INK4a
  1487. Wild type and melanoma-associated mutant p16INK4a proteins do not oligomerize in vivo
  1488. Wild-type p16INK4a suppresses cell growth, telomerase activity and DNA repair in human breast cancer MCF-7 cells
  1489. WRAP53β, survivin and p16INK4a expression as potential predictors of radiotherapy/chemoradiotherapy response in T2N0-T3N0 glottic laryngeal cancer
  1490. Značaj imunohistohemijske ekspresije p16INK4a u razlikovanju inflamacijskih i preneoplastičnih lezija grlića materice
  1491. α-Mangostin induces G1 cell cycle arrest in HCT116 cells through p38MAPK-p16INK4a pathway
  1492. β-Catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development
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