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Melanocortin Obesity

    1. The central MELANOCORTIN system as a treatment target for OBESITY and diabetes: A brief overview
    2. OBESITY and Stress: The MELANOCORTIN Connection
    3. Loss‐of‐function mutations in the MELANOCORTIN‐3 receptor gene confer risk for human OBESITY: A systematic review and meta‐analysis
    4. A unique metalolic sysdrone causes OBESITY in the MELANOCORTIN-3 receptor-deficient mouse
    5. The MELANOCORTIN-4 receptor as target for OBESITY treatment: a systematic review of emerging pharmacological therapeutic options
    6. The MELANOCORTIN pathway and energy homeostasis: From discovery to OBESITY therapy
    7. Clinical spectrum of OBESITY and mutations in the MELANOCORTIN 4 receptor gene
    8. The central MELANOCORTIN system and human OBESITY
    9. OBESITY in the mouse model of pro-opioMELANOCORTIN deficiency responds to peripheral MELANOCORTIN
    10. MELANOCORTIN-4 receptor in energy homeostasis and OBESITY pathogenesis
    11. MELANOCORTIN-4 receptor signalling: importance for weight regulation and OBESITY treatment
    12. Pro-opioMELANOCORTIN processing in the hypothalamus: impact on MELANOCORTIN signalling and OBESITY
    13. Targeted disruption of the MELANOCORTIN-4 receptor results in OBESITY in mice
    14. Neural MELANOCORTIN receptors in OBESITY and related metabolic disorders
    15. MELANOCORTIN signalling and the regulation of blood pressure in human OBESITY
    16. The evidence of metabolic-improving effect of metformin in Ay/a mice with genetically-induced MELANOCORTIN OBESITY and the contribution of hypothalamic …
    17. MELANOCORTIN‐4 receptor complexity in energy homeostasis, OBESITY and drug development strategies
    18. MELANOCORTIN-4 receptor mutations are a frequent and heterogeneous cause of morbid OBESITY
    19. Dominant and recessive inheritance of morbid OBESITY associated with MELANOCORTIN 4 receptor deficiency
    20. Effect of interactions of polymorphisms in the MELANOCORTIN‐4 receptor gene with dietary factors on the risk of OBESITY and Type 2 diabetes: a systematic review
    21. The MELANOCORTIN‐4 receptor pathway and the emergence of precision medicine in OBESITY management
    22. A metabolic defect promotes OBESITY in mice lacking MELANOCORTIN-4 receptors
    23. MELANOCORTIN-4 receptor gene variant I103 is negatively associated with OBESITY
    24. Mutations in ligands and receptors of the leptin–MELANOCORTIN pathway that lead to OBESITY
    25. OBESITY-Associated GNAS Mutations and the MELANOCORTIN Pathway
    26. Mutations in MELANOCORTIN‐4 receptor and human OBESITY
    27. MELANOCORTIN receptor accessory proteins in adrenal disease and OBESITY
    28. MELANOCORTIN‐4 receptor mutations in OBESITY
    29. Molecular mechanisms of the neural MELANOCORTIN receptor dysfunction in severe early onset OBESITY
    30. Effects of acute and chronic administration of the MELANOCORTIN agonist MTII in mice with diet-induced OBESITY
    31. Understanding MELANOCORTIN-4 receptor control of neuronal circuits: toward novel therapeutics for OBESITY syndrome
    32. OBESITY-associated mutations in the MELANOCORTIN 4 receptor provide novel insights into its function
    33. Synaptic input organization of the MELANOCORTIN system predicts diet-induced hypothalamic reactive gliosis and OBESITY
    34. Functional characterization of MELANOCORTIN-4 receptor mutations associated with childhood OBESITY
    35. OBESITY treatment effect in Danish children and adolescents carrying MELANOCORTIN-4 Receptor mutations
    36. Loss of function of the MELANOCORTIN 2 receptor accessory protein 2 is associated with mammalian OBESITY
    37. The role of MELANOCORTIN 3 receptor gene in childhood OBESITY
    38. A Novel MELANOCORTIN 3 Receptor Gene (MC3R) Mutation Associated with Severe OBESITY
    39. Diet-induced OBESITY causes severe but reversible leptin resistance in arcuate MELANOCORTIN neurons
    40. MELANOCORTIN-4 receptor–deficient mice are not hypertensive or salt-sensitive despite OBESITY, hyperinsulinemia, and hyperleptinemia
    41. Effect of setmelanotide, a MELANOCORTIN‐4 receptor agonist, on OBESITY in Bardet‐Biedl syndrome
    42. Gain‐of‐function variants in the MELANOCORTIN 4 receptor gene confer susceptibility to binge eating disorder in subjects with OBESITY: a systematic review and meta …
    43. Tracing the effect of the MELANOCORTIN-4 receptor pathway in OBESITY: study design and methodology of the TEMPO registry
    44. MELANOCORTIN 4 receptor pathway dysfunction in OBESITY: patient stratification aimed at MC4R agonist treatment
    45. The interaction between dietary patterns and MELANOCORTIN-4 receptor polymorphisms in relation to OBESITY phenotypes
    46. OBESITY-associated mutations in the human MELANOCORTIN-4 receptor gene
    47. Peroxisome proliferation–associated control of reactive oxygen species sets MELANOCORTIN tone and feeding in diet-induced OBESITY
    48. Mutations in the human MELANOCORTIN-4 receptor gene associated with severe familial OBESITY disrupts receptor function through multiple molecular mechanisms
    49. Functional characterization of mutations in MELANOCORTIN-4 receptor associated with human OBESITY
    50. Mutations in MELANOCORTIN-3 receptor gene and human OBESITY
    51. Feeding response to MELANOCORTIN agonist predicts preference for and OBESITY from a high-fat diet
    52. Investigation of a genome wide association signal for OBESITY: synthetic association and haplotype analyses at the MELANOCORTIN 4 receptor gene locus
    53. Non-synonymous polymorphisms in MELANOCORTIN-4 receptor protect against OBESITY: the two facets of a Janus OBESITY gene
    54. Functional characterization and structural modeling of OBESITY associated mutations in the MELANOCORTIN 4 receptor
    55. Pro‐opioMELANOCORTIN (POMC) neurones, POMC‐derived peptides, MELANOCORTIN receptors and OBESITY: how understanding of this system has changed over the last …
    56. Polymorphisms and mutations in the MELANOCORTIN-3 receptor and their relation to human OBESITY
    57. Several mutations in the MELANOCORTIN-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited OBESITY in humans
    58. Lateral septum as a MELANOCORTIN downstream site in OBESITY development
    59. The MELANOCORTIN 4 receptor p. Ile269Asn mutation is associated with childhood and adult OBESITY in Mexicans
    60. The brain MELANOCORTIN system, sympathetic control, and OBESITY hypertension
    61. OBESITY due to MELANOCORTIN 4 receptor (MC4R) deficiency is associated with delayed gastric emptying
    62. MELANOCORTIN-4 receptor modulators for the treatment of OBESITY: a patent analysis (2008–2014)
    63. Rapid communication: a novel MELANOCORTIN 4 receptor (MC4R) gene mutation associated with morbid OBESITY
    64. OBESITY as a neuroendocrine disease: lessons to be learned from proopioMELANOCORTIN and MELANOCORTIN receptor mutations in mice and men
    65. Patients with OBESITY caused by MELANOCORTIN-4 receptor mutations can be treated with a glucagon-like peptide-1 receptor agonist
    66. Rare MELANOCORTIN-3 receptor mutations with in vitro functional consequences are associated with human OBESITY
    67. Linkage and association studies between the MELANOCORTIN receptors 4 and 5 genes and OBESITY-related phenotypes in the Quebec Family Study
    68. Hyperphagia, not hypometabolism, causes early onset OBESITY in MELANOCORTIN-4 receptor knockout mice
    69. Implication of heterozygous variants in genes of the leptin–MELANOCORTIN pathway in severe OBESITY
    70. High cortisol response to adrenocorticotrophic hormone identifies ewes with reduced MELANOCORTIN signalling and increased propensity to OBESITY
    71. MELANOCORTIN-4-receptor autoantibodies: a new player in OBESITY
    72. MELANOCORTIN 4 receptor (MC4R) gene variants in children and adolescents having familial early-onset OBESITY: genetic and clinical characteristics
    73. Association of functionally significant MELANOCORTIN-4 but not MELANOCORTIN-3 receptor mutations with severe adult OBESITY in a large North American case–control study
    74. Immunoglobulin G modulation of the MELANOCORTIN 4 receptor signaling in OBESITY and eating disorders
    75. Association of MELANOCORTIN-4 receptor gene polymorphisms with OBESITY-related parameters in Malaysian Malays
    76. Phenotypes in three pedigrees with autosomal dominant OBESITY caused by haploinsufficiency mutations in the MELANOCORTIN-4 receptor gene
    77. MELANOCORTIN-3-receptor gene variants in morbid OBESITY
    78. Poor cell surface expression of human MELANOCORTIN-4 receptor mutations associated with OBESITY
    79. Prevalence of mutations and functional analyses of MELANOCORTIN 4 receptor variants identified among 750 men with juvenile-onset OBESITY
    80. MELANOCORTIN-4 receptor gene: case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene …
    81. Homozygous null mutation of the MELANOCORTIN-4 receptor and severe early-onset OBESITY
    82. OBESITY‐associated mutant MELANOCORTIN‐4 receptors with normal Gαs coupling frequently exhibit other discoverable pharmacological and biochemical defects
    83. OBESITY-associated MELANOCORTIN-4 receptor mutations are associated with changes in the brain response to food cues
    84. Defective MELANOCORTIN 4 receptors in hyperphagia and morbid OBESITY
    85. Pharmacological chaperones for the misfolded MELANOCORTIN-4 receptor associated with human OBESITY
    86. Impact of OBESITY on renal structure and function in the presence and absence of hypertension: evidence from MELANOCORTIN-4 receptor-deficient mice
    87. MELANOCORTIN receptors as targets in the treatment of OBESITY
    88. Mutations in the MELANOCORTIN-3 receptor (MC3R) gene: Impact on human OBESITY or adiposity.
    89. OBESITY due to MELANOCORTIN 4 receptor (MC4R) deficiency is associated with increased linear growth and final height, fasting hyperinsulinemia, and incompletely …
    90. MELANOCORTIN receptor-mediated effects on OBESITY are distributed over specific hypothalamic regions
    91. Early childhood BMI trajectories in monogenic OBESITY due to leptin, leptin receptor, and MELANOCORTIN 4 receptor deficiency
    92. MELANOCORTIN-4 receptor (MC4R) agonists for the treatment of OBESITY
    93. Hypothalamic MELANOCORTIN signaling and leptin resistance—Perspective of therapeutic application for OBESITY-diabetes syndrome
    94. Altered hypothalamic leptin, insulin, and MELANOCORTIN binding associated with moderate-fat diet and predisposition to OBESITY
    95. … genetic variants in autosomal recessive genes of the leptin-MELANOCORTIN signalling pathway are associated with the development of childhood OBESITY
    96. Autosomal-dominant mode of inheritance of a MELANOCORTIN-4 receptor mutation in a patient with severe early-onset OBESITY is due to a dominant-negative effect …
    97. Defect in MAPK signaling as a cause for monogenic OBESITY caused by inactivating mutations in the MELANOCORTIN-4 receptor gene
    98. OBESITY-induced inflammation in white adipose tissue is attenuated by loss of MELANOCORTIN-3 receptor signaling
    99. Subdiaphragmatic vagotomy with pyloroplasty ameliorates the OBESITY caused by genetic deletion of the MELANOCORTIN 4 receptor in the mouse
    100. Effect of the MELANOCORTIN-3 receptor C17A and G241A variants on weight loss in childhood OBESITY
    101. A Novel Homozygous Missense Mutation of MELANOCORTIN-4 Receptor (MC4R) in a Japanese Woman With Severe OBESITY
    102. Polymorphisms in genes involved in the leptin-MELANOCORTIN pathway are associated with OBESITY-related cardiometabolic alterations in a Southern Chilean population
    103. MELANOCORTIN 4 receptor sequence variations are seldom a cause of human OBESITY: the Swedish Obese Subjects, the HERITAGE Family Study, and a Memphis cohort
    104. High prevalence of leptin and MELANOCORTIN-4 receptor gene mutations in children with severe OBESITY from Pakistani consanguineous families
    105. Association of MELANOCORTIN 4 Receptor Gene Single Nucleotide Polymorphism [Rs17782313] In Young OBESITY
    106. MELANOCORTIN-4 receptor gene variants in Chilean families: association with childhood OBESITY and eating behavior
    107. A unique MELANOCORTIN-4-receptor signaling profile for OBESITY-associated constitutively active variants
    108. Low frequency of MELANOCORTIN-4 receptor (MC4R) mutations in a Mediterranean population with early-onset OBESITY
    109. Molecular screening of the human MELANOCORTIN-4 receptor gene: identification of a missense variant showing no association with OBESITY, plasma glucose, or insulin
    110. Signal pathway analysis of selected OBESITY-associated MELANOCORTIN-4 receptor class V mutants
    111. MELANOCORTIN-4 receptor agonists for the treatment of OBESITY
    112. A missense mutation in the human MELANOCORTIN-4 receptor gene in relation to abdominal OBESITY and salivary cortisol
    113. Backbone cyclic peptidomimetic MELANOCORTIN-4 receptor agonist as a novel orally administrated drug lead for treating OBESITY
    114. The MELANOCORTIN system and its role in OBESITY and cachexia
    115. Mutationally induced disulfide bond formation within the third extracellular loop causes MELANOCORTIN 4 receptor inactivation in patients with OBESITY
    116. MELANOCORTIN 4 receptor gene variation is associated with severe OBESITY in Pima Indians
    117. Novel MELANOCORTIN-3 and-4 receptor functional variants in Asian children with severe OBESITY
    118. A novel loss of function MELANOCORTIN-4-receptor mutation (MC4R-F313Sfs* 29) in morbid OBESITY
    119. A novel nonsense mutation in the MELANOCORTIN-4 receptor associated with OBESITY in a Spanish population
    120. Deletion of the feeding-induced hepatokine TSK ameliorates the MELANOCORTIN OBESITY syndrome
    121. Several mutations in the MELANOCORTIN 4 receptor gene are associated with OBESITY in Chinese children and adolescents
    122. Voluntary exercise delays monogenetic OBESITY and overcomes reproductive dysfunction of the MELANOCORTIN-4 receptor knockout mouse
    123. Are Common MELANOCORTIN-3 Receptor Polymorphisms Associated with an Increased Risk of OBESITY in Childhood?
    124. A variant in the fat mass and OBESITY-associated gene (FTO) and variants near the MELANOCORTIN-4 receptor gene (MC4R) do not influence dietary intake
    125. SAT027 Novel OBESITY-Associated MELANOCORTIN 4 Receptor Variants Modulate Signaling Differently
    126. Genetic predisposition to OBESITY in bulimia nervosa: a mutation screen of the MELANOCORTIN-4 receptor gene
    127. OBESITY-linked variants of MELANOCORTIN-4 receptor are misfolded in the endoplasmic reticulum and can be rescued to the cell surface by a chemical chaperone
    128. Inactivation and intracellular retention of the human I183N mutated MELANOCORTIN 3 receptor associated with OBESITY
    129. Understanding gut structure and function associated with MELANOCORTIN OBESITY
    130. Double deletion of MELANOCORTIN 4 receptors and SAPAP3 corrects compulsive behavior and OBESITY in mice
    131. Central role for MELANOCORTIN-4 receptors in offspring hypertension arising from maternal OBESITY
    132. Unravelling the mysterious roles of MELANOCORTIN-3 receptors in metabolic homeostasis and OBESITY using mouse genetics
    133. MELANOCORTIN-4 receptor polymorphism rs17782313: Association with OBESITY and eating in the absence of hunger in Chilean children
    134. Long-acting neurotensin synergizes with liraglutide to reverse OBESITY through a MELANOCORTIN-dependent pathway
    135. A novel MELANOCORTIN-4 receptor gene mutation in a female patient with severe childhood OBESITY
    136. Early leptin response to a palatable diet predicts dietary OBESITY in rats: key role of MELANOCORTIN‐4 receptors in the ventromedial hypothalamic nucleus
    137. Monogenic and complex forms of OBESITY: insights from genetics reveal the leptin-MELANOCORTIN signaling pathway as a common player
    138. Leptin infusion and OBESITY in mouse cause alterations in the hypothalamic MELANOCORTIN system
    139. MELANOCORTIN‐4 receptor and proopioMELANOCORTIN: Candidate genes for OBESITY in domestic shorthair cats
    140. Association study of MELANOCORTIN-4 Receptor (rs17782313) and PKHD1 (rs2784243) variations and early incidence of OBESITY at the age of maturity
    141. Role of the MELANOCORTIN-4 receptor mutations in human OBESITY
    142. Replication of Association Between a Common Variant Near MELANOCORTIN‐4 Receptor Gene and OBESITY‐related Traits in Asian Sikhs
    143. Physical activity and sedentary behaviors modify the association between MELANOCORTIN 4 receptor gene variant and OBESITY in Chinese children and …
    144. Successful treatment with atomoxetine of an adolescent boy with attention deficit/hyperactivity disorder, extreme OBESITY, and reduced MELANOCORTIN 4 receptor function
    145. … of Single nucleotide polymorphism rs17782313 in MELANOCORTIN 4 Receptor Gene with anthropometric indices in normal and OBESITY primary school children in Hanoi
    146. MELANOCORTIN-3 receptor gene variants: association with childhood OBESITY and eating behavior in Chilean families
    147. Feeding responses to a MELANOCORTIN agonist and antagonist in OBESITY induced by a palatable high-fat diet
    148. Monogenic human OBESITY: role of the leptin-MELANOCORTIN system in the regulation of food intake and body weight in humans
    149. Point mutations in the MELANOCORTIN-4 receptor cause variable OBESITY in mice
    150. Molecular therapy of MELANOCORTIN-4-receptor OBESITY by an autoregulatory BDNF vector
    151. Successful methylphenidate treatment of early onset extreme OBESITY in a child with a MELANOCORTIN-4 receptor gene mutation and attention deficit/hyperactivity …
    152. Agouti/MELANOCORTIN interactions with leptin pathways in OBESITY
    153. Neural Programmatic Role of Leptin, TNFα, MELANOCORTIN, and Glutamate in Blood Pressure Regulation vs OBESITY-Related Hypertension in Male C57BL/6 Mice
    154. … -mediated knockdown of MELANOCORTIN-4 receptor in the paraventricular nucleus of the hypothalamus promotes high-fat diet-induced hyperphagia and OBESITY
    155. Variants in genes of the leptin/MELANOCORTIN pathway are involved in 3% of cases of early-onset severe OBESITY
    156. OBESITY due to MELANOCORTIN 4 Receptor (MC4R) Deficiency Is Associated with Increased Linear Growth and Final Height…
    157. Exacerbation of autoimmune uveitis by OBESITY occurs through the MELANOCORTIN 5 receptor
    158. Does OBESITY induce resistance to the long-term cardiovascular and metabolic actions of MELANOCORTIN 3/4 receptor activation?
    159. MELANOCORTIN-3 receptor gene variants in a Maori kindred with OBESITY and early onset type 2 diabetes
    160. Chronic blockade of the MELANOCORTIN 4 receptor subtype leads to OBESITY independently of neuropeptide Y action, with no adverse effects on the gonadotropic and …
    161. Mechanisms underlying hypertension and OBESITY: a MELANOCORTIN linkage in the brain
    162. Anti-MELANOCORTIN-4 receptor autoantibodies in OBESITY
    163. In silico approach to identify non-synonymous SNPs in human OBESITY related gene, MC3R (MELANOCORTIN-3-receptor)
    164. Lean rats with hypothalamic pro-opioMELANOCORTIN overexpression exhibit greater diet-induced OBESITY and impaired central MELANOCORTIN responsiveness
    165. Allelic variants of MELANOCORTIN 3 receptor gene (MC3R) and weight loss in OBESITY: a randomised trial of hypo-energetic high-versus low-fat diets
    166. A novel MELANOCORTIN-4 receptor mutation MC4R-P272L associated with severe OBESITY has increased propensity to be ubiquitinated in the ER in the face of …
    167. CX3CL1 action on microglia protects from diet-induced OBESITY by restoring POMC neuronal excitability and MELANOCORTIN system activity impaired by high-fat …
    168. A Two-Base Deletion–439delGC in the MELANOCORTIN-4 Receptor Promoter Associated with Early-Onset OBESITY
    169. Molecular genetic studies of MELANOCORTIN receptors in morbid OBESITY
    170. MELANOCORTIN-4 receptor and lipocalin 2 gene variants in Spanish children with abdominal OBESITY: effects on BMI-SDS after a lifestyle intervention
    171. Pharmacological Treatment of a Patient with Life-long OBESITY and Heterozygous Complete loss-of-function MELANOCORTIN 4 Receptor Mutation
    172. Targeting MELANOCORTIN receptors for the treatment of OBESITY
    173. Relationship between a near MELANOCORTIN-4 receptor gene variant and puberty timing in children is vague unlike OBESITY
    174. Daisaikoto improves fatty liver and OBESITY in MELANOCORTIN-4 receptor gene-deficient mice via the activation of brown adipose tissue
    175. … in the peroxisome proliferator-activated receptor gamma (PPAR-γ), the fat mass and OBESITY-associated (FTO), and the MELANOCORTIN-4 receptor (MC4R) …
    176. Regulation of PPARγ and OBESITY by agouti/MELANOCORTIN signaling in adipocytes
    177. Counterintuitive effects of double-heterozygous null MELANOCORTIN-4 receptor and leptin genes on diet-induced OBESITY and insulin resistance in C57BL/6J mice
    178. A novel non-synonymous mutation in the MELANOCORTIN-4 receptor gene (MC4R) in a 2-year-old Austrian girl with extreme OBESITY
    179. Understanding the Role of MELANOCORTIN Stimulating Hormone Peptides in Regulation of OBESITY
    180. MELANOCORTIN 1 Receptors in the Hypothalamus of Mice within the Norm and in Diet-Induced OBESITY
    181. Developmental programming of OBESITY and liver metabolism by maternal perinatal nutrition involves the MELANOCORTIN system
    182. Chronic MELANOCORTIN 4 receptor blockage causes OBESITY without influencing sexual behavior in male rats
    183. MELANOCORTIN-4 receptor agonists for the treatment of OBESITY.
    184. GLP-1 receptor agonist treatment in morbid OBESITY and type 2 diabetes due to pathogenic homozygous MELANOCORTIN-4 receptor mutation: a case report
    185. Common MELANOCORTIN-3 receptor variants are not associated with OBESITY, although rs3746619 does influence weight in obese individuals
    186. Enhanced blood pressure and appetite responses to chronic central MELANOCORTIN-3/4 receptor blockade in dietary-induced OBESITY
    187. A phase 3 trial in participants with OBESITY due to Bardet-Biedl syndrome or Alström syndrome: efficacy and safety of the MELANOCORTIN 4 receptor agonist setmelanotide
    188. Promising strategies for OBESITY pharmacotherapy: MELANOCORTIN-4 (MC-4) receptor agonists and melanin concentrating hormone (MCH) receptor-1 antagonists
    189. Late onset OBESITY in mice with targeted deletion of potassium inward rectifier Kir7. 1 from cells expressing the MELANOCORTIN‐4 receptor
    190. Functional characterization of a new human MELANOCORTIN-4 receptor homozygous mutation (N72K) that is associated with early-onset OBESITY
    191. The CNS MELANOCORTIN system: A biological weapon against the threat of OBESITY
    192. Repeating of emotional stress prevents development of MELANOCORTIN OBESITY and type 2 diabetes in the mice with the Agouti yellow mutation
    193. Leptin‐MELANOCORTIN pathway variants and gastric emptying in patients with OBESITY
    194. Effects of Diet-Induced and MELANOCORTIN OBESITY on the Expression of Tryptophan Hydroxylase 2 in Midbrain and Hypothalamus Neurons in Mice
    195. … mechanism of setmelanotide (RM-493) as a potent and first-in-class MELANOCORTIN-4 receptor (MC4R) agonist to treat rare genetic disorders of OBESITY through an in …
    196. The genetics of OBESITY: the role of the MELANOCORTIN 4 receptor
    197. Association of leptin–MELANOCORTIN gene polymorphisms with the risk of OBESITY in northwest Indian population
    198. The effect of diet-induced and MELANOCORTIN OBESITY on expression of tryptophan hydroxylase 2 in the dorsal raphe nucleus and ventral tegmental area in mice
    199. Predictive Analysis of the Leptin-MELANOCORTIN and Adiponectin Signaling Pathways in OBESITY through In Silico Techniques
    200. Reduced anorexigenic efficacy of leptin, but not of the MELANOCORTIN receptor agonist melanotan-II, predicts diet-induced OBESITY in rats
    201. Leptin-MELANOCORTIN system, body weight regulation and OBESITY
    202. Polymorphisms of leptin-MELANOCORTIN system genes associated with OBESITY in an adult population from Barranquilla
    203. … Cyclic Peptides for Human MELANOCORTIN-4 Receptor (MC-4 R): Design, Synthesis, Bioactive Conformation, and Pharmacological Evaluation as an Anti-OBESITY Agent
    204. Nutritional regulation of central fat mass and OBESITY-associated (FTO) expression, and its association with the central MELANOCORTIN signaling in the regulation …
    205. Association between MELANOCORTIN 4 receptor gene polymorphisms and OBESITY
    206. Intracellular retention of human MELANOCORTIN-4 receptor: a molecular mechanism underlying early-onset OBESITY in F261S pedigree of Chinese
    207. Variation analysis of β3‐adrenergic receptor and MELANOCORTIN‐4 receptor genes in childhood OBESITY
    208. OBESITY caused by MELANOCORTIN-4 receptor mutations
    209. S1651 Association of Leptin-MELANOCORTIN Pathway Genetic Variants and OBESITY-Related Phenotypic Traits
    210. Changes of lipid-carbohydrate metabolism during development of MELANOCORTIN OBESITY in the mice with the Agouti yellow mutation
    211. Drugs, exercise, and the MELANOCORTIN-4 receptor—Different means, same ends: Treating OBESITY
    212. Inhibitory effect of the MELANOCORTIN receptor agonist melanotan-II (MTII) on feeding depends on dietary fat content and not OBESITY in rats on free-choice diets
    213. OBESITY-related mutations of leptin and MELANOCORTIN receptors
    214. The Effects of Mutations in MELANOCORTIN-4 Receptors and Ligand Melanocyte-Stimulating Hormone that Cause Inherited OBESITY in Humans
    215. CRTC1 deficiency, specifically in MELANOCORTIN‐4 receptor‐expressing cells, induces hyperphagia, OBESITY, and insulin resistance
    216. Two SNPs associated with type 2 diabetes and OBESITY at MELANOCORTIN-4 receptor gene loci exhibited high Fst values and natural selection
    217. Leptin-MELANOCORTIN Pathway and childhood OBESITY
    218. Leptin-MELANOCORTIN Pathway Mutations and Cardiovascular Morbidity in Patients with OBESITY
    219. Inactivating MELANOCORTIN 4 Receptor Mutations and Human OBESITY
    220. The effect of high-dose metformin on the metabolic parameters and functional state of the liver of agouti-mice with the MELANOCORTIN OBESITY.
    221. CHRONIC CARDIOVASCULAR AND DIETARY RESPONSES TO ACTIVATION OF MELANOCORTIN 3/4 RECEPTORS IN A MODEL OF DIET-INDUCED OBESITY: P …
    222. Optimized High-Yield Purification of OBESITY-Associated MELANOCORTIN 4 Receptor
    223. Pro-opio-MELANOCORTIN deficiency OBESITY–what has it taught us?
    224. Implication of heterozygous variants in genes of the leptin-MELANOCORTIN pathway in severe OBESITY
    225. Functional analysis of MELANOCORTIN-4 receptor variants linked to OBESITY
    226. An Evidence-based Framework to Evaluate MELANOCORTIN-4 Receptor (MC4R) Pathway Relevance for OBESITY-associated Genes
    227. Effect of High-Dose Metformin on the Metabolic Parameters and Functional State of the Liver of Agouti Mice with MELANOCORTIN OBESITY
    228. MELANOCORTIN-4 Receptor Mutation and OBESITY
    229. Peripheral MELANOCORTIN 3 Receptor (MC3R) Regulates Hepatic Autophagy in OBESITY
    230. OBESITY due to mutations in the anorexigenic MELANOCORTIN pathway: a paradigm for OBESITY in Prader-Willi syndrome?
    231. Genetics of OBESITY in Hong Kong Chinese: a candidate gene approach focusing on the MELANOCORTIN-4 receptor andadiponectin
    232. ROLE OF MUTATIONS IN THE MELANOCORTIN-4 RECEPTOR GENE IN CHILDHOOD OBESITY
    233. Bariatric Surgery Improves Glycemia But Not OBESITY in a Family with Inactive MELANOCORTIN 4 Receptor Signaling
    234. Cyclin-dependent kinase 4/6 inhibitors require an arcuate-to-paraventricular hypothalamus MELANOCORTIN circuit to treat diet-induced OBESITY
    235. Rare heterozygous variants in genes of the leptin-MELANOCORTIN satiety pathway contribute to childhood OBESITY
    236. Differential contribution of brain‐region‐specific MELANOCORTIN 5 receptor to physical activity levels in lean vs. OBESITY‐prone rats
    237. Molecular genetic analysis of genes from the leptin-MELANOCORTIN pathway in the pathogenesis of OBESITY
    238. … Variants in MELANOCORTIN 4 Receptor Gene (MC4R) Are Associated with Increased Visceral Fat and Altered Glucose Metabolism Independent of the Effect of OBESITY in …
    239. Motivational and Physiological Dysregulation Due to Development and Onset of OBESITY via MELANOCORTIN 4 Receptor+/-Haploinsufficiency
    240. Role Of Endogenous Brain MELANOCORTIN-4 Receptor Activation In Regulating Blood Pressure And Metabolic Function In Offspring Of Parents With OBESITY
    241. Targeting MELANOCORTIN‐4 receptor (MC4R) agonists to the endoplasmic reticulum (ER) as a potential approach to OBESITY therapy
    242. Clinical and Functional Characterization of MELANOCORTIN 4 Receptor genetic variants in African American and/or Hispanic children with severe early onset OBESITY
    243. OBESITY, Diabetes and Energy Homeostasis: Control of appetite, blood glucose, and blood pressure during MELANOCORTIN-4 receptor activation in …
    244. Activation of leptin receptors in the NTS contributes to the elevated blood pressure in OBESITY via inhibiting NTS MELANOCORTIN signaling
    245. … 3 gene-targeted deletion reduces fat deposition and total body weight in MELANOCORTIN 4 receptor (MC4R)-null mice: A model of hypothalamic-driven late-onset OBESITY …
    246. A novel MELANOCORTIN-4 receptor mutation MC4R-P272L associated with severe OBESITY has increased propensity to be ubiquitinated in the ER in the face of correct …
    247. OBESITY, Diabetes and Energy Homeostasis: Maternal and postnatal high-fat diet consumption programs energy balance and hypothalamic MELANOCORTIN …
    248. MELANOCORTIN 4 receptors in the paraventricular nucleus of the hypothalamus do not mediate chronic metabolic or cardiovascular effects of leptin after established …
    249. Role of MELANOCORTIN receptor-4 in energy regulation and OBESITY
    250. Erratum: Peroxisome proliferation-associated control of reactive oxygen species sets MELANOCORTIN tone and feeding in diet-induced OBESITY (Nature Medicine (2011) …
    251. Association analysis of Leptin MELANOCORTIN signaling pathway genes with diabetes and OBESITY
    252. Investigations of MELANOCORTIN-receptor genes in patients with severe childhood OBESITY
    253. A Phase 2 Trial of the MELANOCORTIN-4 Receptor Agonist Setmelanotide in OBESITY Due to SRC1 Insufficiency: Body Weight, Body Mass Index Z Score, and Safety …
    254. MELANOCORTIN 4 receptor and children OBESITY
    255. … -targeted deletion reduces fat deposition and total body weight in MELANOCORTIN 4 receptor (MC4R)-null mice: A model of hypothalamic-driven late-onset OBESITY …
    256. 193 ACUTE HIGH FAT DIET ACTIVATES CENTRAL MELANOCORTIN PATHWAYS CONTRIBUTING TO OBESITY RELATED HYPERTENSION.
    257. The role of MELANOCORTIN 3 receptor gene in childhood OBESITY.
    258. Understanding MELANOCORTIN-4 receptor control of neuronal circuits: toward novel therapeutics for OBESITY syndrome.
    259. MELANOCORTIN 4 receptor genetics in defining the morbid OBESITY in general population: common polymorphisms vs mutations
    260. Mutational Analysis of the MELANOCORTIN-4 Receptor Gene in Chinese Children with OBESITY
    261. MELANOCORTIN reverses OBESITY in POMC-deficient mice
    262. Association of MELANOCORTIN-4 receptor gene polymorphisms with OBESITY-related parameters in Malaysian Malays.
    263. Morphological characteristics of liver and white adipose tissue during development of MELANOCORTIN OBESITY in C57Bl/6J Agouti yellow mutant mice
    264. Role of MELANOCORTIN 4 Receptor (Mc4R) in OBESITY
    265. MELANOCORTIN receptors mediate renal sympathetic activation to leptin in OBESITY
    266. OBESITY-associated MELANOCORTIN-4 receptor mutations are associated with changes in the brain response to food cues.
    267. Relationship between MELANOCORTIN 4 receptor (MC4R) gene polymorphism, diet, physical activity and OBESITY in children
    268. 389 PATHOPHYSIOLOGY OF OBESITY AND HYPERTENSION: ROLE OF CNS LEPTIN-MELANOCORTIN SYSTEM
    269. Impact of OBESITY on Renal Structure and Function in The Absence of Hypertension: Evidence From MELANOCORTIN‐4 Receptor (MC4R) Deficient Mice
    270. … of peripheral [alpha]-MELANOCORTIN stimulating hormone ([alpha]-MSH) in childhood craniopharyngioma patients in comparison with other forms of childhood OBESITY
    271. [OM3-1]: Hypothalamic MELANOCORTIN receptor 4 signaling in control of OBESITY
    272. PD. 05. Evidence of early life programming of the MELANOCORTIN-4 receptor in leptin induced hypertension arising from maternal OBESITY
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