Insulin & Aging

The endocrine regulation of aging by insulin -like signals
aging and insulin secretion
Mechanisms of insulin resistance in aging
Brain insulin and insulin receptors in aging and sporadic Alzheimer’s disease
Characterization of the insulin resistance of aging .
insulin resistance with aging
Glucose intolerance and aging : evidence for tissue insensitivity to insulin
insulin resistance of muscle protein metabolism in aging
insulin resistance in aging is related to abdominal obesity
The insulin paradox: aging , proteotoxicity and neurodegeneration
insulin and aging
Decreased cognitive function in aging non- insulin -dependent diabetic patients
insulin , aging , and the brain: mechanisms and implications
insulin regulation of heart function in aging fruit flies
Effect of exercise on insulin action, glucose tolerance, and insulin secretion in aging
Viral mediated expression of insulin -like growth factor I blocks the aging -related loss of skeletal muscle function
Removal of visceral fat prevents insulin resistance and glucose intolerance of aging : an adipokine-mediated process?
Cardiac stem cell and myocyte aging , heart failure, and insulin -like growth factor-1 overexpression
Physical inactivity and obesity underlie the insulin resistance of aging
Alcohol intake and insulin levels: the Normative aging Study
Contribution of visceral fat mass to the insulin resistance of aging
Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat.
insulin /IGF-like signalling, the central nervous system and aging
Minireview: role of the growth hormone/ insulin -like growth factor system in mammalian aging
Effects of aging on insulin secretion
The role of insulin , insulin growth factor, and insulin -degrading enzyme in brain aging and Alzheimer’s disease
The relationship between insulin -like growth factor-I, adiposity, and aging
Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity
insulin -like growth factors I and II: aging and bone density in women
Effect of physical training on the insulin resistance of aging
Growth hormone, insulin -like growth factor-1 and the aging cardiovascular system
insulin Resistance and β-Cell Dysfunction in aging : The Importance of Dietary Carbohydrate
insulin -like growth factor-I, cognition and brain aging
insulin /IGF-1 paradox of aging : regulation via AKT/IKK/NF-κB signaling
Effect of aging on insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of rats
Impact of reduced insulin ‐like growth factor‐1/ insulin signaling on aging in mammals: novel findings
insulin -like growth factor 1 (IGF-1) and aging : controversies and new insights
Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging
Relationship of dietary saturated fatty acids and body habitus to serum insulin concentrations: the Normative aging Study
The role of insulin and neurotrophic factor signaling in brain aging and Alzheimer’s Disease
The aging brain. Changes in the neuronal insulin / insulin receptor signal transduction cascade trigger late-onset sporadic Alzheimer disease (SAD). A mini-review
Growth hormone and insulin -like growth factor-1 (IGF-1) and their influence on cognitive aging
Methionine‐deficient diet extends mouse lifespan, slows immune and lens aging , alters glucose, T4, IGF‐I and insulin levels, and increases hepatocyte MIF levels and …
insulin and glucagon relationships during aging in man
insulin -like signaling, metabolism, stress resistance and aging in Caenorhabditis elegans
Effect of aging on response to exercise training in humans: skeletal muscle GLUT-4 and insulin sensitivity
insulin -like growth factors and aging
Effects of glucose/ insulin perturbations on aging and chronic disorders of aging : the evidence.
Fetuin-null mice are protected against obesity and insulin resistance associated with aging
Baseline ventilatory function predicts the development of higher levels of fasting insulin and fasting insulin resistance index: the Normative aging Study
Uric acid and coronary heart disease risk: evidence for a role of uric acid in the obesity- insulin resistance syndrome: the Normative aging Study
Human growth hormone and cortisol response to insulin stimulation in aging
TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance
aging and the growth hormone/ insulin like growth factor-I axis
aging , synaptic dysfunction, and insulin -like growth factor (IGF)-1
Leucine metabolism in aging humans: effect of insulin and substrate availability
Influence of insulin , sympathetic nervous system activity, and obesity on blood pressure: the Normative aging Study.
The key role of growth hormone– insulin –IGF-1 signaling in aging and cancer
aging impairs insulin -stimulated glucose uptake in rat skeletal muscle via suppressing AMPKα
Pleiotropic effects of growth hormone and insulin -like growth factor (IGF)-1 on biological aging : inferences from moderate caloric-restricted animals
Long-lived Klotho mice: new insights into the roles of IGF-1 and insulin in aging
Decrease in glucose-stimulated insulin secretion with aging is independent of insulin action
Methionine restriction decreases visceral fat mass and preserves insulin action in aging male Fischer 344 rats independent of energy restriction
The metabolic clearance of insulin and the feedback inhibition of insulin secretion are altered with aging
Mitochondrial function, energy expenditure, aging and insulin resistance
Functional implications of Drosophila insulin -like peptides in metabolism, aging , and dietary restriction
Change of insulin action with aging in conscious rats determined by euglycemic clamp
The role of insulin /IGF-like signaling in C. elegans longevity and aging
Handgrip strength and insulin levels: cross-sectional and prospective associations in the Normative aging Study
The demography of slow aging in male and female Drosophila mutant for the insulin ‐receptor substrate homologue chico
Activin signaling targeted by insulin /dFOXO regulates aging and muscle proteostasis in Drosophila
The enteric enhancement of glucose-stimulated insulin release: the role of GIP in aging , obesity, and non- insulin -dependent diabetes mellitus
Reduced pancreatic B cell compensation to the insulin resistance of aging : impact on pro insulin and insulin levels
Role of serum insulin -like growth factor I in mammalian brain aging
Exercise in aging : its important role in mortality, obesity and insulin resistance
Impairments in availability of insulin to liver in vivo and in binding of insulin to purified hepatic plasma membrane during aging
Glucocorticoid effects on insulin -and IGF-I-regulated muscle protein metabolism during aging
Estradiol, insulin -like growth factor-I and brain aging
Circulating levels of insulin -like growth factor (IGF) binding protein-1 and-3 in aging men: relationships to insulin , glucose, IGF, and dehydroepiandrosterone sulfate …
Adipocyte insulin resistance: effects of aging , obesity, exercise, and food restriction
Association of prostate cancer risk with insulin , glucose, and anthropometry in the Baltimore longitudinal study of aging
insulin binding to cultured human fibroblasts increases with normal and precocious aging
Low doses of insulin -like growth factor-I induce mitochondrial protection in aging rats
Growth hormone, insulin -like growth factor-1 and the aging brain
aging -dependent and-independent modulation of associative learning behavior by insulin / insulin -like growth factor-1 signal in Caenorhabditis elegans
… serum correlates of aging in the healthy human male: progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin -like …
The DAF‐2 insulin ‐like signaling pathway independently regulates aging and immunity in C. elegans
Reduction in the chondrocyte response to insulin ‐like growth factor 1 in aging and osteoarthritis: studies in a non‐human primate model of naturally occurring disease
insulin -like growth factor isoforms in skeletal muscle aging , regeneration, and disease
Relationship between changes in body composition and insulin responsiveness in models of the aging rat
Effects of aging and sex on plasma insulin -like growth factor I (IGF-I) levels in normal adults
… of nitrotyrosine in aging and osteoarthritic cartilage: correlation of oxidative damage with the presence of interleukin‐1β and with chondrocyte resistance to insulin …
aging is associated with decreased suppression of insulin -like growth factor binding protein-1 by insulin
insulin sensitivity of rat skeletal muscle: effects of starvation and aging .
… decreases in insulin -like growth factor-I and transforming growth factor-beta in femoral cortical bone from both men and women: implications for bone loss with aging
Influence of aging on insulin receptor binding and metabolic effects of insulin on human adipose tissue
SIRT1, neuronal cell survival and the insulin /IGF-1 aging paradox
… , blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: the Cocoa, Cognition, and aging …
Epigenetic oxidative redox shift (EORS) theory of aging unifies the free radical and insulin signaling theories
insulin /IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination
Impaired β-cell function in human aging : response to nicotinic acid-induced insulin resistance
Body size, insulin /IGF signaling and aging in the nematode Caenorhabditis elegans
insulin /IGF-1 signaling pathway driving aging and cancer as a target for pharmacological intervention
Effect of diet restriction on glucose metabolism and insulin responsiveness in aging rats
The nature of insulin secretory defect in aging rats
insulin regulates aging and oxidative stress in Anopheles stephensi
Low doses of insulin -like growth factor I improve insulin resistance, lipid metabolism, and oxidative damage in aging rats
Glucose intolerance, insulin resistance, and pathological features of Alzheimer disease in the Baltimore Longitudinal Study of aging
aging is associated with resistance to effects of leptin on fat distribution and insulin action
Differential effects of aging and insulin -like growth factor-1 on synapses in CA1 of rat hippocampus
Temporal relations between obesity and insulin : longitudinal data from the Normative aging Study
Growth hormone, insulin and aging : the benefits of endocrine defects
insulin -like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function
Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues
Human aging is associated with parallel reductions in insulin and amylin release
insulin resistance is associated with cognition among HIV-1-infected patients: the Hawaii aging With HIV cohort
Role of CBP and SATB-1 in aging , dietary restriction, and insulin -like signaling
insulin exposure and aging theory
The insulin -like growth factor I generation test: resistance to growth hormone with aging and estrogen replacement therapy
Dehydroepiandrosterone (DHEA) replacement decreases insulin resistance and lowers inflammatory cytokines in aging humans
In Vivo insulin -Dependent Glucose Uptake of Specific Tissues Is Decreased during aging of Mature Wistar Rats
Does aging intensify the insulin resistance of human obesity?
aging and insulin secretion
Effects of aging and dietary restriction on tissue protein synthesis: relationship to plasma insulin -like growth factor-1
insulin -like growth factor-1 in CNS and cerebrovascular aging
aging -associated insulin resistance predisposes to hypertension and its reversal by exercise: the role of vascular vasorelaxation to insulin
Oxidative stress contributes to aging by enhancing pancreatic angiogenesis and insulin signaling
insulin -like growth factors (IGFs): implications for aging
Alterations in the ultradian oscillations of insulin secretion and plasma glucose in aging
Increased Susceptibility to insulin Resistance Associated with Abdominal Obesity in aging Rats**
Glucose and amino acid metabolism in aging man: differential effects of insulin
Reduced brain insulin -like growth factor I function during aging
The immune-endocrine loop during aging : role of growth hormone and insulin -like growth factor-I
… on food intake and plasma CCK, leptin, and insulin concentrations in older and young adults: evidence for increased CCK activity as a cause of the anorexia of aging
Essential role of protein tyrosine phosphatase 1B in obesity‐induced inflammation and peripheral insulin resistance during aging
aging and cancer-related loss of insulin -like growth factor 2 imprinting in the mouse and human prostate
Cardiac-specific overexpression of insulin -like growth factor 1 attenuates aging -associated cardiac diastolic contractile dysfunction and protein damage
Ability of insulin to modulate hepatic glucose production in aging rats is impaired by fat accumulation
insulin action in aging man: Evidence for tissue-specific differences at low physiologic insulin levels
Influence of adiposity in the blunted whole-body protein anabolic response to insulin with aging
Deficiency of insulin -like growth factor 1 reduces sensitivity to aging -associated cardiomyocyte dysfunction
Gender differences in hypertrophy, insulin resistance and ischemic injury in the aging type 2 diabetic rat heart
Myosteatosis and myofibrosis: relationship with aging , inflammation and insulin resistance
Role of impaired intracellular glucose metabolism in the insulin resistance of aging
Mitochondrial function and insulin resistance during aging –a mini-review
Metabolic triad in brain aging : mitochondria, insulin /IGF-1 signalling and JNK signalling
Metabolic consequences of incorrect insulin administration techniques in aging subjects with diabetes
Growth hormone/ insulin -like growth factor-I axis in aging : a summary of a National Institutes of aging -Sponsored Symposium
Oxidative aging and insulin receptor signaling
Articular chondrocytes from aging rats respond poorly to insulin -like growth factor-1: an altered signaling pathway
Chronic 17β-estradiol treatment improves skeletal muscle insulin signaling pathway components in insulin resistance associated with aging
Diverse roles of growth hormone and insulin -like growth factor-1 in mammalian aging : progress and controversies
Growth hormone induces somatostatin and insulin -like growth factor I gene expression in the cerebral hemispheres of aging rats
insulin Growth Factor‐I Inhibits Apoptosis in Hematopoietic: Progenitor Cells Implications in Thymic aging a
A possible role for insulin in the altered capability for hepatic enzyme adaptation during aging
The paradox of neuronal insulin action and resistance in the development of aging -associated diseases
insulin is differentially related to cognitive decline and atrophy in Alzheimer’s disease and aging
Impaired ventilatory function and elevated insulin levels in nondiabetic males: the Normative aging Study
MCH−/− mice are resistant to aging -associated increases in body weight and insulin resistance
LET‐60 RAS modulates effects of insulin /IGF‐1 signaling on development and aging in Caenorhabditis elegans
Effect of aging on the sensitivity of growth hormone secretion to insulin -like growth factor-I negative feedback
insulin resistance and aging : a cause or a protective response?
Which anthropometric indices of regional adiposity are related to the insulin resistance of aging ?
Altered regulation of insulin secretion in isolated islets of different sizes in aging rats
Aberrant insulin receptor signaling and amino acid homeostasis as a major cause of oxidative stress in aging
Regulation of excitation contraction coupling by insulin -like growth factor-1 in aging skeletal muscle.
Hostility and urine norepinephrine interact to predict insulin resistance: the VA Normative aging Study
Relationship of serum fibroblast growth factor 21 with abnormal glucose metabolism and insulin resistance: the Baltimore Longitudinal Study of aging
insulin resistance and fat patterning with aging : relationship to metabolic risk factors for cardiovascular disease
Appendicular skeletal muscle mass and insulin resistance in an elderly Korean population: the Korean social life, health and aging project-health examination …
insulin receptor kinase activity in rat adipocytes is decreased during aging
Diet, not aging , causes skeletal muscle insulin resistance
Accelerated fat cell aging links oxidative stress and insulin resistance in adipocytes
Interaction of multiplication stimulating activity/rat insulin -like growth factor II with skeletal muscle satellite cells during aging
… gene expression of insulin receptor isoforms A and B and insulin receptor substrates 1, 2 and 3 in rat tissues: modulation by aging and differentiation in rat …
insulin receptors in the brain cortex of aging mice
aging enhances the insulin resistance in obesity through both receptor and postreceptor alterations
Training-induced enhancement of insulin action in human skeletal muscle: the influence of aging
Targeted disruption of inducible nitric oxide synthase protects against aging , S-nitrosation, and insulin resistance in muscle of male mice
Intranasal insulin improves age-related cognitive deficits and reverses electrophysiological correlates of brain aging
Changes in insulin receptor kinase with aging in rat skeletal muscle and liver
Changes in protein, carbohydrate, and fat metabolism with aging : possible role of insulin
Tissue‐specific insulin signaling in the regulation of metabolism and aging
Effect of age and caloric restriction on insulin receptor binding and glucose transporter levels in aging rats
Adipose tissue-derived tumor necrosis factor activity correlates with fat cell size but not insulin action in aging rats
insulin resistance and depressive symptoms in middle-aged and elderly Chinese: findings from the Nutrition and Health of aging Population in China Study
The role of the glucose transport system in the postreceptor defect in insulin action associated with human aging
Metallothionein antagonizes aging ‐induced cardiac contractile dysfunction: role of PTP1B, insulin receptor tyrosine phosphorylation and Akt
Modulation of SIRT1-Foxo1 signaling axis by resveratrol: implications in skeletal muscle aging and insulin resistance
Caloric restriction and insulin -like growth factors in aging and cancer
insulin exposure controls the rate of mammalian aging
aging and insulin resistance in a group of nonobese male volunteers
The endothelium abridges insulin resistance to premature aging
Metabolic effects of resveratrol in mammals-a link between improved insulin action and aging
Effect of gender on insulin resistance associated with aging
Genetic inactivation of GIP signaling reverses aging -associated insulin resistance through body composition changes
Impaired mitochondrial fatty acid oxidation and insulin resistance in aging : novel protective role of glutathione
aging and oxidative stress reduce the response of human articular chondrocytes to insulin ‐like growth factor 1 and osteogenic protein 1
Influence of cardiac‐specific overexpression of insulin ‐like growth factor 1 on lifespan and aging ‐associated changes in cardiac intracellular Ca2+ homeostasis …
Effects of aging on dehydroepiandrosterone sulfate in relation to fasting insulin levels and body composition assessed by bioimpedance analysis
insulin regulation in AhR-null mice: embryonic cardiac enlargement, neonatal macrosomia, and altered insulin regulation and response in pregnant and aging AhR …
β cell aging markers have heterogeneous distribution and are induced by insulin resistance
Melatonin can improve insulin resistance and aging -induced pancreas alterations in senescence-accelerated prone male mice (SAMP8)
Dissociation between metabolic and vascular insulin resistance in aging
aging and Restriction of Dietary Calories Increases insulin Receptor mRNA, and aging Increases Glucocorticoid Receptor MRNA in the Liver of Female C3B10RF1 …
Method of treating reduced insulin -like growth factor and bone loss associated with aging
Regulation of insulin receptor mRNA splicing in rat tissues: effect of fasting, aging , and diabetes
The ubiquitin ligase CHIP integrates proteostasis and aging by regulation of insulin receptor turnover
Secretion of insulin during aging
aging is associated with elevated muscle triglyceride content and increased insulin -stimulated fatty acid uptake
insulin in aging and cancer: antidiabetic drug Diabenol as geroprotector and anticarcinogen
Regulation of insulin secretion by glucose during aging
Effect of aging on insulin secretory function and expression of beta cell function-related genes of islets
insulin Release in aging : Dynamic Response of Isolated Islets of Langerhans of the Rat to D-Glucose and D-Glycer aldehyde
Serum insulin ‐like growth factor‐1 binding proteins 1 and 2 and mortality in older adults: the Health, aging , and Body Composition Study
Relationships between insulin -like growth hormone factor-I and estradiol in reproductive aging
Loss of postprandial insulin sensitization during aging
aging is associated with increased HbA1c levels, independently of glucose levels and insulin resistance, and also with decreased HbA1c diagnostic specificity
Longevity pathways (mTOR, SIRT, insulin /IGF-1) as key modulatory targets on aging and neurodegeneration
Interaction between insulin -like growth factor-1 and atherosclerosis and vascular aging
The effect of aging on insulin signalling pathway is tissue dependent: central role of adipose tissue in the insulin resistance of aging
aging does not affect the activation of the myocyte insulin -like growth factor-1 autocrine system after infarction and ventricular failure in Fischer 344 rats
Effects of epinephrine on insulin secretion and action in humans: interaction with aging
Restorative effect of intracerebroventricular insulin -like growth factor-I gene therapy on motor performance in aging rats
Effects of aging on insulin synthesis and secretion. Differential effects on prepro insulin messenger RNA levels, pro insulin biosynthesis, and secretion of newly made …
Increased expression of type 1 insulin -like growth factor receptor messenger RNA in rat hippocampal formation is associated with aging and behavioral impairment
insulin /IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain
aging and insulin resistance: just say iNOS
… and normal prostate aging : differences in types I and II 5 alpha-reductase and steroid hormone receptor messenger ribonucleic acid (mRNA) levels, but not in insulin …
aging per se increases the susceptibility to free fatty acid–induced insulin resistance
aging and insulin sensitivity: role of blood pressure and sympathetic nervous system activity
Stress contributes to the development of central insulin resistance during aging : implications for Alzheimer’s disease
L-type Ca2+ channel- insulin -like growth factor-1 receptor signaling impairment in aging rat skeletal muscle
Rats with low brain angiotensinogen do not exhibit insulin resistance during early aging
insulin -like growth factor-1 stimulation of protein synthesis is attenuated in cerebral cortex of aging rats
insulin -like growth factor-I receptor densities in human frontal cortex and white matter during aging , in Alzheimer’s disease, and in Huntington’s disease
Serum levels of insulin ‐like growth factor 1 in subjects with osteoarthritis of the knee. Data from the baltimore longitudinal study of aging
Parental imprinting regulates insulin -like growth factor signaling: a Rosetta Stone for understanding the biology of pluripotent stem cells, aging and …
From lipodystrophy and insulin resistance to metabolic syndrome: HIV infection, treatment and aging
aging does not contribute to the decline in insulin action on storage of muscle glycogen in rats
Glucose intolerance and insulin resistance with aging —studies on insulin receptors and post-receptor events
aging is associated with myocardial insulin resistance and mitochondrial dysfunction
… disruption of spermidine/spermine N1‐acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging
Synthesis-secretion coupling of insulin : effect of aging .
… metabolic alterations in the hippocampus caused by insulin signalling dysfunction and its association with cognitive impairment during aging and Alzheimer’s disease …
Effect of aging on the expression of peroxisome proliferator-activated receptor γ and the possible relation to insulin resistance
Heat shock factor-1 intertwines insulin /IGF-1, TGF-β and cGMP signaling to control development and aging
insulin exposure and unifying aging
Diminished anabolic signaling response to insulin induced by intramuscular lipid accumulation is associated with inflammation in aging but not obesity
Dexamethasone-induced insulin resistance and pancreatic adaptive response in aging rats are not modified by oral vanadyl sulfate treatment
insulin release in aging : studies on adenylate cyclase, phosphodiesterase, and protein kinase in isolated islets of Langerhans of the rat
Effect of aging on the kinetic characteristics of the insulin receptor autophosphorylation in rat adipocytes
Short-term estradiol administration in aging ovariectomized rats provides lasting benefits for memory and the hippocampus: a role for insulin -like growth factor-I
DAF-2/ insulin -like signaling in C. elegans modifies effects of dietary restriction and nutrient stress on aging , stress and growth
insulin ‐like growth factor‐I gene therapy increases hippocampal neurogenesis, astrocyte branching and improves spatial memory in female aging rats
Meal-related increases in vascular reactivity are impaired in older and diabetic adults: insights into roles of aging and insulin in vascular flow
Dietary (−)-Epigallocatechin-3-gallate supplementation counteracts aging -associated skeletal muscle insulin resistance and fatty liver in senescence-accelerated …
Serum insulin -like growth factor binding protein (IGFBP)-4 and IGFBP-5 levels in aging and age-associated diseases
Post-developmental microRNA expression is required for normal physiology, and regulates aging in parallel to insulin /IGF-1 signaling in C. elegans
Development of insulin resistance during aging : involvement of central processes and role of adipokines