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Gsk3 (Inhibitor | Inhibitors)

  1. GSK3 inhibitors: development and therapeutic potential
  2. The conundrum of GSK3 inhibitors: is it the dawn of a new beginning?
  3. Discovery and development of GSK3 inhibitors for the treatment of type 2 diabetes
  4. GSK3 inhibitors and disease
  5. GSK3 inhibitors show benefits in an Alzheimer’s disease (AD) model of neurodegeneration but adverse effects in control animals
  6. GSK3 inhibitors in the therapeutic development of diabetes, cancer and neurodegeneration: past, present and future
  7. Immune checkpoint inhibition in syngeneic mouse cancer models by a silicasome nanocarrier delivering a GSK3 inhibitor
  8. The development of potent and selective bisarylmaleimide GSK3 inhibitors
  9. Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors
  10. Activation of Wnt/β-catenin signalling via GSK3 inhibitors direct differentiation of human adipose stem cells into functional hepatocytes
  11. Effects of GSK3 inhibitors on in vitro expansion and differentiation of human adipose-derived stem cells into adipocytes
  12. A modified EpiSC culture condition containing a GSK3 inhibitor can support germline-competent pluripotency in mice
  13. The selective GSK3 inhibitor, SAR502250, displays neuroprotective activity and attenuates behavioral impairments in models of neuropsychiatric symptoms of …
  14. GSK3 Inhibitors Regulate MYCN mRNA Levels and Reduce Neuroblastoma Cell Viability through Multiple Mechanisms, Including p53 and Wnt Signaling
  15. Rats treated with AZD2858, a GSK3 inhibitor, heal fractures rapidly without endochondral bone formation
  16. Oral administration of a GSK3 inhibitor increases brain insulin-like growth factor I levels
  17. GSK3 inhibitor-induced dentinogenesis using a hydrogel
  18. QSAR, docking, and CoMFA studies of GSK3 inhibitors
  19. GSK3 inhibitor-BIO regulates proliferation of immortalized pancreatic mesenchymal stem cells (iPMSCs)
  20. GSK3 inhibitor-loaded osteotropic Pluronic hydrogel effectively mitigates periodontal tissue damage associated with experimental periodontitis
  21. GSK3 inhibitors CHIR99021 and 6-bromoindirubin-3′-oxime inhibit microRNA maturation in mouse embryonic stem cells
  22. Testing Fmr1KO Phenotypes in Response to GSK3 Inhibitors: SB216763 versus AFC03127
  23. From on‐target to off‐target activity: identification and optimisation of Trypanosoma brucei GSK3 inhibitors and their characterisation as anti‐Trypanosoma brucei drug …
  24. Donor cell engineering with GSK3 inhibitor–loaded nanoparticles enhances engraftment after in utero transplantation
  25. Evidence for antimanic efficacy of glycogen synthase kinase-3 (GSK3) inhibitors in a strain-specific model of acute mania
  26. GSK3 inhibitor ameliorates steatosis through the modulation of mitochondrial dysfunction in hepatocytes of obese patients
  27. GSK3 inhibitors enhance retinoic acid receptor activity and induce the differentiation of retinoic acid-sensitive myeloid leukemia cells
  28. EGF and a GSK3 inhibitor deplete junctional E-cadherin and stimulate proliferation in the mature mammalian ear
  29. Control of Hes7 Expression by Tbx6, the Wnt Pathway and the Chemical Gsk3 Inhibitor LiCl in the Mouse Segmentation Clock
  30. Glycogen synthase kinase 3 (GSK3) inhibitor, SB-216763, promotes pluripotency in mouse embryonic stem cells
  31. The GSK3 kinase inhibitor lithium produces unexpected hyperphosphorylation of β-catenin, a GSK3 substrate, in human glioblastoma cells
  32. Stable generation of serum‐and feeder‐free embryonic stem cell‐derived mice with full germline‐competency by using a GSK3 specific inhibitor
  33. The novel potent GSK3 inhibitor AF3581 reverts fragile X syndrome phenotype
  34. Effect of Gsk3 inhibitor CHIR99021 on aneuploidy levels in rat embryonic stem cells
  35. GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation
  36. Three inhibitors of FGF receptor, ERK, and GSK3 establishes germline‐competent embryonic stem cells of C57BL/6N mouse strain with high efficiency and stability
  37. A novel GSK3 inhibitor that promotes self-renewal in mouse embryonic stem cells
  38. GSK3 inhibitor AR-A014418 promotes osteogenic differentiation of human adipose-derived stem cells via ERK and mTORC2/Akt signaling pathway
  39. The E3 ubiquitin ligases β-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in …
  40. Docking and quantitative structure–activity relationship of oxadiazole derivates as inhibitors of GSK3
  41. Cell cycle reactivation of cochlear progenitor cells in neonatal FUCCI mice by a GSK3 small molecule inhibitor
  42. GSK3 inhibitor suppresses cell growth and metabolic process in FLT3-ITD leukemia cells
  43. Targeting GSK3 from Ustilago maydis: Type-II Kinase Inhibitors as Potential Antifungals
  44. Tacrine, an oral acetylcholinesterase inhibitor, induced hepatic oxidative damage, which was blocked by liquiritigenin through GSK3-beta inhibition
  45. Derivation of Mouse Embryonic Stem (ES) Cell Lines Using Small-Molecule Inhibitors of Erk and Gsk3 Signaling (2i).
  46. Bikinin-like inhibitors targeting GSK3/Shaggy-like kinases: characterisation of novel compounds and elucidation of their catabolism in planta
  47. GSK3 inhibitor enhances gemtuzumab ozogamicin‐induced apoptosis in primary human leukemia cells by overcoming multiple mechanisms of resistance
  48. The PI3 kinase inhibitor NVP-BKM120 induces GSK3/FBXW7-dependent Mcl-1 degradation, contributing to induction of apoptosis and enhancement of TRAIL …
  49. Glucose dependence of glycogen synthase activity regulation by GSK3 and MEK/ERK inhibitors and angiotensin-(1–7) action on these pathways in cultured human …
  50. Non-canonical Smads phosphorylation induced by the glutamate release inhibitor, riluzole, through GSK3 activation in melanoma
  51. Differential effects of glycogen synthase kinase 3 (GSK3) inhibition by lithium or selective inhibitors in the central nervous system
  52. In vitro and in vivo antitumor and anti-inflammatory capabilities of the novel GSK3 and CDK9 inhibitor ABC1183
  53. From simple quinoxalines to potent oxazolo [5, 4-f] quinoxaline inhibitors of glycogen-synthase kinase 3 (GSK3)
  54. Novel optimization of valmerins (tetrahydropyrido [1, 2-a] isoindolones) as potent dual CDK5/GSK3 inhibitors
  55. Glycogen synthase kinase 3 (GSK3): its role and inhibitors
  56. Glycogen synthase kinase 3 (GSK3)-inhibitor SB216763 promotes the conversion of human umbilical cord mesenchymal stem cells into neural precursors in adherent …
  57. A phase I dose-escalation, pharmacokinetic (PK), and pharmacodynamic (PD) evaluation of intravenous LY2090314 a GSK3 inhibitor administered in combination …
  58. Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial PfGSK3/PfPK6 with Activity against Blood Stage Parasites In Vitro
  59. Synergistic effects of GSK3 and p38 MAPK inhibitors on growth of Plasmodium falciparum ex vivo.
  60. Evaluation of in vivo lithium chloride effects as a GSK3-β inhibitor on human adipose derived stem cells differentiation into oligodendrocytes and re-myelination in an …
  61. Phosphorylation of the inhibitor-2 of protein phosphatase-1 by cdc2-cyclin B and GSK3
  62. Inhibition of Tat-mediated HIV-1 replication and neurotoxicity by novel GSK3-beta inhibitors
  63. The protein phosphatase-1/inhibitor-2 complex differentially regulates GSK3 dephosphorylation and increases sarcoplasmic/endoplasmic reticulum calcium ATPase 2 …
  64. Different concentrations of GSK3 inhibitor fail to suppress interleukin-6 in stimulated THP-1 macrophage
  65. Supplementation of freezing/thawing media with GSK3 inhibitor alsterpaullone does not bypass the harmful effect of cryopreservation on boar spermatozoa
  66. Evaluation of AChE inhibitors and dual AChE/GSK3-β inhibitor as Alzheimer’s disease treatment
  67. Identification of a first in class GSK3-alpha selective inhibitor as a new differentiation therapy for AML
  68. 195 Effects of Gsk3 Inhibitor on the Pluripotency Maintenance of Buffalo Embryonic Stem-Cell-Like Cells
  69. Targeting BRCA2 deficiency with GSK3 inhibitors
  70. Evaluation of Lithium chloride effects as a GSK3-β inhibitor on human Adipose Derived Stem cells differentiation into oligodendrocytes and re-myelination in animal …
  71. GSK3 Kinase Inhibitor, CHIR, Suppress Transcription of Tissue Specific POU2F1 Isoform in Burkitt Namalwa Lymphoma Cells
  72. Assessment of the regenerative ability of two GSK3 inhibitors (Tideglusib & CHIR99021) on the Wnt/beta catenin pathway activation, the proliferative capacity, and the …
  73. Evaluation of hepatic activity of immunomodulatory compounds and GSK3 inhibitors
  74. Effect of Kenpaullone, a Specific Inhibitor of GSK3, on Melanin Synthesis in B16 Melanoma and Human Melanocytes
  75. Preferential Selectivity of Inhibitors with Human Tau Protein Kinase Gsk3 Elucidates Their Potential Roles for Off-Target Alzheimer’s Therapy
  76. THE EFFECT OF GLYCOGEN SYNTHASE KINASE3 (GSK3) INHIBITOR ON PROLIFERATION OF NEURAL STEM CELLS
  77. Back Cover: From On‐Target to Off‐Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti …
  78. … of AtherosclerosisPart II: The Role of RNase L in Lipopolysaccharide-Induced Lung InflammationPart III: Development of LC-MS/MS Assay for GSK3 Inhibitors …
  79. BIO (6-bromoindirubin-3′-oxime) GSK3 inhibitor induces dopaminergic differentiation of human immortalized RenVm cells
  80. GSK3 plays a crucial role in determining cell response to mTOR inhibitors
  81. Combination of GSK3 and HDAC inhibitors increases gene expression efficiency to the hypoxia/neuron-specific system: an optimal experimental scheme in treating …
  82. Targeting GSK3 from Ustilago maydis: Type-II kinase inhibitors as potential antifungals
  83. Computational analysis of conformational changes in GSK3-β/CDK2 kinases for understanding inhibitor selectivity
  84. Glycogen synthase kinase 3 (GSK3) inhibitor 6-bromoindirubin-3′-oxime (BIO) promotes the proliferation of mouse male germline stem cells (mGSCs) under serum …
  85. Effects of GSK3-β Inhibitors on Wnt Signaling in Zebrafish Fin Regeneration: Chemical Biology
  86. Abstract B33: Transient upregulation of Myc with GSK3-β inhibitors in B-cell lymphomas enhances p53-independent apoptotic responses to chemotherapy
  87. Treatment with the autophagy inhibitor 3-Methyladenine sensitizes pancreatic cancer cells to GSK3 inhibition-induced apoptosis
  88. Thiadiazolidinone-8, a GSK3 beta inhibitor, ameliorates aldosterone-induced cardiac inflammation and fibrosis by regulating autophagy
  89. Glycogen Synthase Kinase 3-Beta (GSK3-β) inhibitors decrease protein degradation in L6 myotubes
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