Gambogic Acid

Gambogic Acid (Garcinia hanburyi)

1. Studies on chemical modification and biology of a natural product, gambogic acid (II): Synthesis and bioevaluation of gambogellic acid and its derivatives from gambogic acid as antitumor agents
2. Inducing cell cycle arrest and apoptosis by dimercaptosuccinic acid modified Fe3O4 magnetic nanoparticles combined with nontoxic concentration of bortezomib andgambogic acid in RPMI-8226 cells
3. The Next Generation Non-competitive Active Polyester Nanosystems for Transferrin Receptor-mediated Peroral Transport Utilizinggambogic acid as a Ligand
4. Crystallization of Pseudopolymorphs of Some Gamboge Pigments. Pyridine, Dimethylformamide and Dimethylsulfoxide Solvates of Morellic Acid,gambogic acid and Guttiferic Acid
5. Studies on chemical structure modification and biology of a natural product,gambogic acid (I): Synthesis and biological evaluation of oxidized analogues ofgambogic acid
6. 1213901. Synthesis and anti-tumor activity of NO-donating derivatives ofgambogic acid
7. 345. Gamboge. Part I. The constitutions of the acids C 11 H 10 O 4 and C 12 H 10 O 6 derived fromgambogic acid
8. 47gambogic acid delivery using lipid nanoparticles modified with cell-penetrating peptide
9. A novel dual sensitive polymer-gambogic acid conjugate: synthesis, characterization, and in vitro evaluation
10. A novel exploration of a combination ofgambogic acid with TiO2 nanofibers: The photodynamic effect for HepG2 cell proliferation
11. A novel redox/pH dual-responsive and hyaluronic acid-decorated multifunctional magnetic complex micelle for targetedgambogic acid delivery for the treatment of …
12. A Probe into mechanism ofgambogic acid-induced apoptosis in SPC-A-1 lung adenocarcinoma cells [J]
13. A role for transferrin receptor in triggering apoptosis when targeted withgambogic acid
14. A solvent-assisted active loading technology to preparegambogic acid and all-trans retinoic acid co-encapsulated liposomes for synergistic anticancer therapy
15. Absolute configuration of (−)-gambogic acid, an antitumor agent
16. Abstract# 4392: Role of transferrin receptor 1 and Src ingambogic acid-induced apoptosis
17. Advance on Mechanisms in Antitumor Effect ofgambogic acid and Its Derivates [J]
18. Aminated β-cyclodextrin-grafted Fe 3 O 4-loadedgambogic acid magnetic nanoparticles: preparation, characterization, and biological evaluation
19. Aminated β-cyclodextrin-grafted Fe₃O₄-loadedgambogic acid magnetic nanoparticles: preparation, characterization, and biological evaluation
20. An open-labeled, randomized, multicenter phase IIa study ofgambogic acid injection for advanced malignant tumors
21. An open-labeled, randomized, multicentered, phase IIa study for advanced cancer treatment bygambogic acid injection (THS).
22. An oxidative analogue ofgambogic acid-induced apoptosis of human hepatocellular carcinoma cell line HepG2 is involved in its anticancer activity in vitro
23. Anticancer effect and apoptosis induction ofgambogic acid in human gastric cancer line BGC-823
24. Anticancer effect and apoptosis induction ofgambogic acid in human leukemia cell line K562 in vitro
25. Anticancer effect ofgambogic acid in gastric cancer line SGC-7901
26. Anti-CD22-conjugated CdTe QDs co-loaded with doxorubicin andgambogic acid: a novel platform for lymphoma treatment
27. Anti-EGFR-iRGD recombinant protein modified biomimetic nanoparticles loaded withgambogic acid to enhance targeting and antitumor ability in colorectal …
28. Anti‑inflammatory effects ofgambogic acid in murine collagen‑induced arthritis through PI3K/Akt signaling pathway
29. Anti-invasive effect ofgambogic acid in MDA-MB-231 human breast carcinoma cells
30. Antimetastatic Effects ofgambogic acid are Mediated via the Actin Cytoskeleton and NF‐κ B Pathways in SK‐HEP 1 Cells
31. Antiproliferative activity ofgambogic acid isolated from Garcinia hanburyi in Hep3B and Huh7 cancer cells
32. Antitumor activity ofgambogic acid on NCI-H1993 xenografts via MET signaling pathway downregulation
33. Apoptosis induction associated with the ER stress response through up-regulation of JNK in HeLa cells bygambogic acid
34. Apoptosis-inducing effect ofgambogic acid on K562 cells and its mechanism
35. Apoptotic effect ofgambogic acid in esophageal squamous cell carcinoma cells via suppression of the NF-κB pathway
36. Application of Probe Drugs for Detecting Influences ofgambogic acid on Cytochrome P450 Isoforms
37. Autophagy inhibition promotesgambogic acid-induced suppression of growth and apoptosis in glioblastoma cells
38. Bromodomain‑containing protein 4 is critical for the antiproliferative and pro‑apoptotic effects ofgambogic acid in anaplastic thyroid cancer
39. Calcium channel blocker verapamil acceleratesgambogic acid-induced cytotoxicity via enhancing proteasome inhibition and ROS generation
40. Caspase-8 preferentially senses the apoptosis-inducing action of NG-18, agambogic acid derivative, in human leukemia HL-60 cells
41. CD44 targeted redox-triggered self-assembly with magnetic enhanced EPR effects for effective amplification ofgambogic acid to treat triple-negative breast cancer
42. Cell penetrating peptides functionalizedgambogic acid-nanostructured lipid carrier for cancer treatment
43. Cell-penetrating peptide conjugates ofgambogic acid enhance the antitumor effect on human bladder cancer EJ cells through ROS-mediated apoptosis
44. Co-delivery ofgambogic acid and TRAIL plasmid by hyaluronic acid grafted PEI-PLGA nanoparticles for the treatment of triple negative breast cancer
45. Combination ofgambogic acid with cisplatin enhances the antitumor effects on cisplatin-resistant lung cancer cells by downregulating MRP2 and LRP …
46. Combined therapy with EGFR TKI andgambogic acid for overcoming resistance in EGFR‑T790M mutant lung cancer
47. Comparative studies on biophysical interactions betweengambogic acid and serum albumin via multispectroscopic approaches and molecular docking
48. Comparison of electron capture—atmospheric pressure chemical ionization and electrospray ionization for the analysis ofgambogic acid and its main circulating …
49. Computational study on the conformations ofgambogic acid
50. Crystal structure of the pyridine salt ofgambogic acid
51. Cytotoxic effect ofgambogic acid on SH-SY5Y neuroblastoma cells is mediated by intrinsic caspase-dependent signaling pathway
52. Daunorubicin andgambogic acid coloaded cysteamine-CdTe quantum dots minimizing the multidrug resistance of lymphoma in vitro and in vivo
53. Design and synthesis ofgambogic acid analogs as potent cytotoxic and anti-inflammatory agents
54. Determination of Content and Entrapment Efficiency of Neo-gambogic acid Nanoparticles by HPLC
55. Determination ofgambogic acid in dog plasma by high‐performance liquid chromatography for a pharmacokinetic study
56. Determination ofgambogic acid in Gamboge by non-aqueous capillary electrophoresis
57. Determination ofgambogic acid in human plasma by liquid chromatography-atmospheric pressure chemical ionization–mass spectrometry
58. Determination of the content ofgambogic acid and gambogenic acid in gamboge by HPLC
59. Determination of the Content ofgambogic acid and Neo-gambogic acid in Gamboge by HPLC
60. Determination of Totalgambogic acid in Gamboge by ZrOCl_2 Colorimetry
61. Development of a more efficient albumin-based delivery system forgambogic acid with low toxicity for lung cancer therapy
62. Development of a safety and efficacy nanoemulsion delivery system encapsulatedgambogic acid for acute myeloid leukemia in vitro and in vivo
63. Differential apoptotic induction ofgambogic acid, a novel anticancer natural product, on hepatoma cells and normal hepatocytes
64. Dimeric c (RGD) peptide conjugated nanostructured lipid carriers for efficient delivery ofgambogic acid to breast cancer
65. Discovery, characterization and SAR ofgambogic acid as a potent apoptosis inducer by a HTS assay
66. Down-regulation of chemokine receptor CXCR4 bygambogic acid suppresses metastasis of pancreatic cancer in an orthotopic mouse model
67. Effect of gambogic acid on cell apoptosis and expressions of Bax, Bcl-2 and Caspase-3 in colorectal cancer cells with
68. Effect ofgambogic acid on proliferation and apoptosis in 786-O cells
69. Effect ofgambogic acid on proliferation and apoptosis of human diffuse large B-cell lymphoma cell line OCI-LY-1
70. Effect ofgambogic acid on proliferation and invasion in colon cancer LoVo cell line
71. Effect ofgambogic acid on proliferation of SKM-1 cells and its mechanism
72. Effect ofgambogic acid on the proliferation of human colon carcinoma cell SW480 and the expression of VEGFR2 [J]
73. Effect ofgambogic acid on the regulation of hERG channel in K562 cells in vitro
74. Effect on proliferation and apoptosis and regulation on nucleoporin Nup88 in acute leukemic cell U937 bygambogic acid
75. Effects ofgambogic acid on Bladder Cancer Cells
76. Effects ofgambogic acid on human telomerase reverse transcriptase and Bcl-2 protein in human osteosarcoma cells
77. Effects ofgambogic acid on regulation of steroid receptor coactivator-3 in lung adenocarcinoma A549 cells
78. Effects ofgambogic acid on the activation of caspase-3 and downregulation of SIRT1 in RPMI-8226 multiple myeloma cells via the accumulation of ROS
79. Effects ofgambogic acid on the Production of Reactive Oxygen Species and Neutrophil Extracellular Traps
80. EFFECTS OFgambogic acid ON THE PROLIFERATION AND CELL APOPTOSIS OF CELL LINE NCI-H929IN MULTIPLE MYELOMA
81. Effects ofgambogic acid on the regulation of nucleoporin Nup88 in HL-60 cells
82. Effects ofgambogic acid on the regulation of nucleoporin Nup88 in U937 cells
83. Effects ofgambogic acid on the regulation of steroid receptor coactivator-3 in A549 cells
84. Effects of magnetic nanoparticle Fe_3O_4 on apoptosis of HepG2 cells induced bygambogic acid
85. Effects of magnetic nanoparticle of Fe3O4 on apoptosis induced bygambogic acid in U937 leukemia cells.
86. Effects of magnetic nanoparticles of Fe3O4 combinated withgambogic acid on apoptosis of SMMC-7721 cells
87. Enhanced cytotoxicity of an anti-transferrin receptor IgG3-avidin fusion protein in combination withgambogic acid against human malignant hematopoietic …
88. Enhancement of anticancer efficacy of chemotherapeutics bygambogic acid against gastric cancer cells
89. Evaluation of in vitro and in vivo antitumor effects ofgambogic acid-loaded layer-by-layer self-assembled micelles
90. Experimental study on effects ofgambogic acid with cisplatin to human osteosarcoma cells
91. Experimental study ongambogic acid-induced gastric cancer cell apoptosis and anti-tumor metastasis
92. Experimental study ongambogic acid-induced gastric cancer cell apoptosis and anti-tumor metastasis.
93. Exploration of acute genotoxic effects and antigenotoxic potential ofgambogic acid using Allium cepa assay
94. Fine-tuning vitamin E-containing telodendrimers for efficient delivery ofgambogic acid in colon cancer treatment
95. Folate‐decorated arginine‐based poly (ester urea urethane) nanoparticles as carriers forgambogic acid and effect on cancer cells
96. Functional inhibition of Hsp70 by Pifithrin-μ switchesgambogic acid induced caspase dependent cell death to caspase independent cell death in human …
97. GA3, a newgambogic acid derivative, exhibits potent antitumor activities in vitro via apoptosis-involved mechanisms
98. Gamboge. Part IV. Scission ofgambogic acid by alkali
99. gambogic acid
100. gambogic acid activates AMP-activated protein kinase in mammalian cells
101. gambogic acid Affects Ribosomal Occurrence in Glioma Cells by Downregulating the Phosphoinositide Kinase-3/Protein Kinase B/Mammalian Target of Rapamycin …
102. ambogic acid ameliorates diabetes-induced proliferative retinopathy through inhibition of the HIF-1α/VEGF expression via targeting PI3K/AKT pathway
103. ambogic acid ameliorates diabetes-induced proliferative retinopathy through inhibition of the HIF-1α/VEGF expression via targeting PI3K/AKT pathway
104. ambogic acid and celastrol are two powerful anti-inflammatory drugs in arthritis
105. ambogic acid and epiambogic acid, C-2 epimers with novel anticancer effects from Garcinia hanburyi
106. ambogic acid and inhibition of tumor growth: a close association
107. ambogic acid and its analogs inhibit gap junctional intercellular communication
108. ambogic acid and its role in chronic diseases
109. ambogic acid as a Non‐Competitive Inhibitor of ATP‐Binding Cassette Transporter B1 Reverses the Multidrug Resistance of Human Epithelial Cancers by …
110. ambogic acid attenuates liver fibrosis by inhibiting the PI3K/AKT and MAPK signaling pathways via inhibiting HSP90
111. ambogic acid binds to human CB2 receptors and exhibits potential partial agonist activity
112. ambogic acid causes fin developmental defect in zebrafish embryo partially via retinoic acid signaling
113. ambogic acid combined with CdTe QDs for leukemia cancer cells inhibition and their bio-safety for rat brain
114. ambogic acid counteracts mutant p53 stability by inducing autophagy
115. ambogic acid covalently interacts with IKK-2 to inhibit the NF-kB signaling pathway
116. ambogic acid covalently modifies IκB kinase-β subunit to mediate suppression of lipopolysaccharide-induced activation of NF-κB in macrophages
117. ambogic acid deactivates cytosolic and mitochondrial thioredoxins by covalent binding to the functional domain
118. ambogic acid disrupts toll-like receptor4 activation by blocking lipopolysaccharides binding to myeloid differentiation factor 2
119. ambogic acid down-regulates MDM2 oncogene and induces p21Waf1/CIP1 expression independent of p53
120. ambogic acid efficiently kills stem-like colorectal cancer cells by upregulating zfp36 expression
121. ambogic acid enhances proteasome inhibitor-induced anticancer activity
122. ambogic acid enhances the radiosensitivity of human esophageal cancer cells by inducing reactive oxygen species via targeting Akt/mTOR pathway
123. ambogic acid exerts cardioprotective effects in a rat model of acute myocardial infarction through inhibition of inflammation, iNOS and NF‑κB/p38 pathway
124. ambogic acid exhibits anti-metastatic activity on malignant melanoma mainly through inhibition of PI3K/Akt and ERK signaling pathways
125. ambogic acid exhibits anti-psoriatic efficacy through inhibition of angiogenesis and inflammation
126. ambogic acid grafted low molecular weight heparin micelles for targeted treatment in a hepatocellular carcinoma model with an enhanced anti-angiogenesis effect
127. ambogic acid identifies an isoform-specific druggable pocket in the middle domain of Hsp90β
128. ambogic acid impairs tumor angiogenesis by targeting YAP/STAT3 signaling axis
129. ambogic acid improves non-small cell lung cancer progression by inhibition of mTOR signaling pathway
130. ambogic acid increases the sensitivity to paclitaxel in drug‑resistant triple‑negative breast cancer via the SHH signaling pathway
131. ambogic acid Induced Apoptosis through Activation of Caspase-dependent Pathway in Aortic Smooth Muscle Cells
132. ambogic acid induced oxidative stress dependent caspase activation regulates both apoptosis and autophagy by targeting various key molecules (NF-κB, Beclin-1 …
133. ambogic acid induced tumor cell apoptosis by T lymphocyte activation in H22 transplanted mice
134. ambogic acid induces apoptosis and inhibits colorectal tumor growth via mitochondrial pathways
135. ambogic acid induces apoptosis and regulates expressions of Bax and Bcl-2 protein in human gastric carcinoma MGC-803 cells
136. ambogic acid induces apoptosis and sensitizes TRAIL-mediated apoptosis through downregulation of cFLIPL in renal carcinoma Caki cells
137. ambogic acid induces apoptosis by regulating the expression of Bax and Bcl‐2 and enhancing caspase‐3 activity in human malignant melanoma A375 cells
138. ambogic acid induces apoptosis in diffuse large B-cell lymphoma cells via inducing proteasome inhibition
139. ambogic acid induces apoptosis in hepatocellular carcinoma SMMC-7721 cells by targeting cytosolic thioredoxin reductase
140. ambogic acid Induces Apoptosis in Imatinib-Resistant
141. ambogic acid induces apoptosis in imatinib-resistant chronic myeloid leukemia cells via inducing proteasome inhibition and caspase-dependent Bcr-Abl …
142. ambogic acid induces apoptosis of human malignant melanoma A375 cells
143. ambogic acid induces apoptosis of Jurkat cell through the MAPK signal pathway
144. ambogic acid Induces Apoptosis of Non-Small Cell Lung Cancer (NSCLC) Cells by Suppressing Notch Signaling
145. ambogic acid induces apoptosis of SK-MES-1 lung cancer cells
146. ambogic acid induces apoptotic cell death in T98G glioma cells
147. ambogic acid induces autophagy and combines synergistically with chloroquine to suppress pancreatic cancer by increasing the accumulation of reactive …
148. ambogic acid Induces Cell Apoptosis and Inhibits MAPK Pathway in PTEN−/−/p53−/− Prostate Cancer Cells In Vitro and Ex Vivo
149. ambogic acid induces cell apoptosis through endoplasmic reticulum stress triggered inhibition of Akt signaling pathways in extranodal NK/T-cell lymphoma cells
150. ambogic acid induces death inducer‐obliterator 1‐mediated apoptosis in Jurkat T cells
151. ambogic acid induces death of K562 cells through autophagy and apoptosis mechanisms
152. ambogic acid induces EGFR degradation and Akt/mTORC1 inhibition through AMPK dependent-LRIG1 upregulation in cultured U87 glioma cells
153. ambogic acid induces G0/G1 arrest and apoptosis involving inhibition of SRC-3 and inactivation of Akt pathway in K562 leukemia cells
154. ambogic acid induces G0/G1 cell cycle arrest and cell migration inhibition via suppressing PDGF receptor β tyrosine phosphorylation and Rac1 activity in rat aortic …
155. ambogic acid induces growth inhibition and differentiation via upregulation of p21waf1/cip1 expression in acute myeloid leukemia cells
156. ambogic acid induces heme oxygenase-1 through Nrf2 signaling pathway and inhibits NF-κB and MAPK activation to reduce inflammation in LPS-activated …
157. ambogic acid induces mitochondria-dependent apoptosis by modulation of Bcl-2 and Bax in mantle cell lymphoma JeKo-1 cells
158. ambogic acid induces Raji cell apoptosis in vitro and its mechanism
159. ambogic acid induces the apoptosis an d arrests thec ycleo f human bladder cancer cells
160. ambogic acid induces the apoptosis and autophagic cell death in human hepatoma cells
161. ambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling
162. ambogic acid inhibits angiogenesis through inhibiting PHD2–VHL–HIF-1α pathway
163. ambogic acid inhibits angiogenesis through suppressing vascular endothelial growth factor-induced tyrosine phosphorylation of KDR/Flk-1
164. ambogic acid inhibits cell proliferation via suppressing epithelial growth factor receptor tyrosine phosphorylation in rat aortic smooth muscle cell
165. ambogic acid inhibits chemokine receptor CXCR4 signaling pathways and osteoclastogenesis in multiple myeloma
166. ambogic acid inhibits growth, induces apoptosis, and overcomes drug resistance in human colorectal cancer cells
167. ambogic acid inhibits Hsp90 and deregulates TNF-α/NF-κB in HeLa cells
168. ambogic acid inhibits Hsp90 and deregulates TNF-α/NF-κB in HeLa cells.
169. ambogic acid inhibits Hsp90 expressions in thiram-induced tibial dyschondroplasia
170. ambogic acid inhibits invasion of osteosarcoma via upregulation of TIMP-1
171. ambogic acid inhibits LPS-induced macrophage pro-inflammatory cytokine production mainly through suppression of the p38 pathway
172. ambogic acid inhibits malignant melanoma cell proliferation through mitochondrial p66shc/ROS-p53/Bax-mediated apoptosis
173. ambogic acid Inhibits Melanoma through Regulation of miR‐199a‐3p/ZEB1 Signalling
174. ambogic acid inhibits multiple myeloma mediated osteoclastogenesis through suppression of chemokine receptor CXCR4 signaling pathways
175. ambogic acid inhibits osteoclast formation and ovariectomy-induced osteoporosis by suppressing the JNK, p38 and Akt signalling pathways
176. ambogic acid inhibits proliferation of human lung carcinoma SPC-A1 cells in vivo and in vitro and represses telomerase activity and telomerase reverse transcriptase …
177. ambogic acid inhibits spinal cord injury and inflammation through suppressing the p38 and Akt signaling pathways
178. ambogic acid inhibits STAT3 phosphorylation through activation of protein tyrosine phosphatase SHP-1: potential role in proliferation and apoptosis
179. ambogic acid inhibits the catalytic activity of human topoisomerase IIα by binding to its ATPase domain
180. ambogic acid inhibits the growth of osteosarcoma cells in vitro by inducing apoptosis and cell cycle arrest
181. ambogic acid inhibits the growth of ovarian cancer tumors by regulating p65 activity
182. ambogic acid inhibits thioredoxin activity and induces ROS-mediated cell death in castration-resistant prostate cancer
183. ambogic acid inhibits TNF-α-induced invasion of human prostate cancer PC3 cells in vitro through PI3K/Akt and NF-κB signaling pathways
184. ambogic acid inhibits tumor cell adhesion by suppressing integrin β1 and membrane lipid rafts-associated integrin signaling pathway
185. ambogic acid is a novel anti-cancer agent that inhibits cell proliferation, angiogenesis and metastasis
186. ambogic acid is a tissue-specific proteasome inhibitor in vitro and in vivo
187. ambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins
188. ambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system
189. ambogic acid lysinate induces apoptosis in breast cancer MCF-7 cells by increasing reactive oxygen species
190. ambogic acid mediates apoptosis as a p53 inducer through down-regulation of mdm2 in wild-type p53-expressing cancer cells
191. ambogic acid mediates transferrin receptor-1 phosphorylation leading to jnk-dependant apoptosis
192. ambogic acid moderates cardiac responses to chronic hypoxia likely by acting on the proteasome and NF-κB pathway
193. ambogic acid potentiates clopidogrel-induced apoptosis and attenuates irinotecan-induced apoptosis through down-regulating human carboxylesterase 1 and-2
194. ambogic acid potentiates the chemosensitivity of colorectal cancer cells to 5‑fluorouracil by inhibiting proliferation and inducing apoptosis
195. ambogic acid prevents angiotensin II‑induced abdominal aortic aneurysm through inflammatory and oxidative stress dependent targeting the PI3K/Akt/mTOR and NF …
196. ambogic acid promotes apoptosis and resistance to metastatic potential in MDA-MB-231 human breast carcinoma cells
197. ambogic acid protects from endotoxin shock by suppressing pro-inflammatory factors in vivo and in vitro
198. ambogic acid reduced bcl-2 expression via p53 in human breast MCF-7 cancer cells
199. ambogic acid regulates the migration and invasion of colorectal cancer via microRNA‑21‑mediated activation of phosphatase and tensin homolog
200. ambogic acid reverses oxaliplatin resistance in colorectal cancer by increasing intracellular platinum levels
201. ambogic acid sensitizes breast cancer cells to TRAIL-induced apoptosis by promoting the crosstalk of extrinsic and intrinsic apoptotic signalings
202. ambogic acid sensitizes gemcitabine efficacy in pancreatic cancer by reducing the expression of ribonucleotide reductase subunit-M2 (RRM2)
203. ambogic acid sensitizes ovarian cancer cells to doxorubicin through ROS-mediated apoptosis
204. ambogic acid sensitizes resistant breast cancer cells to doxorubicin through inhibiting P-glycoprotein and suppressing survivin expression
205. ambogic acid Shows Anti-Proliferative Effects on Non-Small Cell Lung Cancer (NSCLC) Cells by Activating Reactive Oxygen Species (ROS)-Induced …
206. ambogic acid suppresses cancer invasion and migration by inhibiting TGFβ1-induced epithelial-to-mesenchymal transition
207. ambogic acid suppresses colon cancer cell activity in vitro
208. ambogic acid suppresses cytochrome P450 3A4 by downregulating pregnane X receptor and up-regulating DEC1 in human hepatoma HepG2 cells
209. ambogic acid suppresses hypoxia‐induced hypoxia‐inducible factor‐1α/vascular endothelial growth factor expression via inhibiting phosphatidylinositol 3‐kinase …
210. ambogic acid suppresses inflammation in rheumatoid arthritis rats via PI3K/Akt/mTOR signaling pathway
211. ambogic acid suppresses pressure overload cardiac hypertrophy in rats
212. ambogic acid synergistically potentiates cisplatin-induced apoptosis in non-small-cell lung cancer through suppressing NF-κB and MAPK/HO-1 signalling
213. ambogic acid triggers DNA damage signaling that induces p53/p21Waf1/CIP1 activation through the ATR-Chk1 pathway
214. ambogic acid triggers vacuolization-associated cell death in cancer cells via disruption of thiol proteostasis
215. ambogic acid, a natural product inhibitor of Hsp90
216. ambogic acid, a potent inhibitor of survivin, reverses docetaxel resistance in gastric cancer cells
217. ambogic acid: A Caged Prenylated Garcinia Xanthone: Potent Anticancer Agent of Pharmaceutical Promise
218. ambogic acid-encapsulated polymeric micelles improved therapeutic effects on pancreatic cancer
219. ambogic acid-induced autophagy in nonsmall cell lung cancer NCI-H441 cells through a reactive oxygen species pathway
220. ambogic acid‐induced degradation of mutant p53 is mediated by proteasome and related to CHIP
221. ambogic acid-induced G 2 /M phase cell-cycle arrest via disturbing CDK7-mediated phosphorylation of CDC2/p34 in human gastric carcinoma BGC …
222. ambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment
223. ambogic acid-loaded electrosprayed particles for site-specific treatment of hepatocellular carcinoma
224. ambogic acid-loaded magnetic Fe3O4 nanoparticles inhibit Panc-1 pancreatic cancer cell proliferation and migration by inactivating transcription factor …
225. ambogic acid-loaded PEG–PCL nanoparticles act as an effective antitumor agent against gastric cancer
226. ambogic acid-loaded pH-sensitive mixed micelles for overcoming breast cancer resistance
227. ambogic acid-loaded polymeric micelles for improved therapeutic effect in breast cancer
228. General pharmacological properties, developmental toxicity, and analgesic activity ofgambogic acid, a novel natural anticancer agent
229. Global profiling of cellular targets ofgambogic acid by quantitative chemical proteomics
230. Hyaluronic acid-decorated redox-sensitive chitosan micelles for tumor-specific intracellular delivery ofgambogic acid
231. Hypoxia-induced resistance to cisplatin-mediated apoptosis in osteosarcoma cells is reversed bygambogic acid independently of HIF-1α
232. Identification and quantitative determination of a major circulating metabolite ofgambogic acid in human
233. Identification ofgambogic acid metabolites in rat bile by liquid chromatography-tandem mass spectrometry-ion trap-time-of-flight
234. Improved druggability ofgambogic acid using core–shell nanoparticles
235. Improving aqueous solubility and antitumor effects by nanosizedgambogic acid-mPEG2000 micelles
236. Inclusion complex from cyclodextrin-grafted hyaluronic acid and pseudo protein as biodegradable nano-delivery vehicle forgambogic acid
237. Induction of programmed erythrocyte death bygambogic acid
238. Inhibition effect ofgambogic acid on MUTZ-1 cell line and its possible mechanism
239. Inhibition of glioblastoma growth and angiogenesis bygambogic acid: an in vitro and in vivo study
240. Inhibition of human telomerase reverse transcriptase gene expression bygambogic acid in human hepatoma SMMC-7721 cells
241. Inhibition of inwardly rectifying Kir2.x channels by the novel anti-cancer agentgambogic acid depends on both pore block and PIP2 interference
242. Inhibition of Murine Macrophage Inwardly Rectifying Kir2. 1 Channels bygambogic acid
243. Inhibition of α4 integrin mediated adhesion was involved in the reduction of B16-F10 melanoma cells lung colonization in C57BL/6 mice treated withgambogic acid
244. Interaction betweengambogic acid and dihydrofolate reductase and synergistic lethal effects with methotrexate on hepatoma cells
245. Involvement of E-cadherin/AMPK/mTOR axis in LKB1-induced sensitivity of non-small cell lung cancer togambogic acid
246. Involvement of matrix metalloproteinase 2 and 9 ingambogic acid induced suppression of MDA-MB-435 human breast carcinoma cell lung metastasis
247. Involvement of RECK ingambogic acid induced anti‐invasive effect in A549 human lung carcinoma cells
248. Involvement of Regulations of Nucleophosmin and Nucleoporins ingambogic acid‐Induced Apoptosis in Jurkat Cells
249. Isolation and structure of neo-ambogic acid from Gamboge (Garcinia hanburryi)
250. Magnetic and CD44 receptor dual targeting redox-responsive polymeric micelle for precise delivery ofgambogic acid to triple-negative breast cancer
251. Mechanism ofgambogic acid-induced apoptosis in Raji cells
252. Mechanisms ofgambogic acid-induced apoptosis in non-small cell lung cancer cells in relation to transferrin receptors
253. Metabolism and metabolic inhibition ofgambogic acid in rat liver microsomes
254. Metabolism ofgambogic acid in rats: a rare intestinal metabolic pathway responsible for its final disposition
255. Methyl jasmonate sensitizes human bladder cancer cells togambogic acid‐induced apoptosis through down‐regulation of EZH 2 expression by miR‐101
256. Michael acceptor ingambogic acid—Its role and application for potent antitumor agents
257. Microtubule depolymerization and phosphorylation of c-Jun N-terminal kinase-1 and p38 were involved ingambogic acid induced cell cycle arrest and apoptosis in …
258. Modified chitosan derivative micelle system for natural anti-tumor productgambogic acid delivery
259. Molecular formula and identity of β-guttiferin and α-ambogic acid
260. Molecular targets ofgambogic acid in cancer: recent trends and advancements
261. Multifunctional effects of Cys–CdTe QDs conjugated withgambogic acid for cancer cell tracing and inhibition
262. Nanodelivery ofgambogic acid by functionalized graphene enhances inhibition of cell proliferation and induces G 0/G 1 cell cycle arrest in cervical, ovarian, and …
263. Nanodelivery ofgambogic acid by functionalized graphene enhances inhibition of cell proliferation and induces G₀/G₁ cell cycle arrest in cervical, ovarian, and …
264. Nanomedicine-based combination ofgambogic acid and retinoic acid chlorochalcone for enhanced anticancer efficacy in osteosarcoma
265. Nanoparticle delivery and combination therapy ofgambogic acid and all-trans retinoic acid
266. Nanoparticles with optimal ratiometric co-delivery of docetaxel withgambogic acid for treatment of multidrug-resistant breast cancer
267. New targets for the antitumor activity ofgambogic acid in hematologic malignancies
268. Next-Generation Noncompetitive Nanosystems Based ongambogic acid: In Silico Identification of Transferrin Receptor Binding Sites, Regulatory Shelf Stability, and …
269. N-octyl-N-arginine-chitosan (OACS) micelles forgambogic acid oral delivery: preparation, characterization and its study on in situ intestinal perfusion
270. N-octyl-N-arginine-chitosan micelles forgambogic acid intravenous delivery: characterization, cell uptake, pharmacokinetics, and biodistribution
271. Novel long-circulating liposomes consisting of PEG modified β-sitosterol forgambogic acid delivery
272. Optimization of Extracting Process of Neo-ambogic acid [J]
273. Optimization of Extraction Process ofgambogic acid [J]
274. Optimization of the formulation ofgambogic acid nanosuspensions by the central composite design-response surface methodology
275. Optimizing extraction process of neo-ambogic acid from gamboge by orthogonal test [J]
276. PEG prodrug ofgambogic acid: Amino acid and dipeptide spacer effects
277. PEG–PLGA–PLL nanoparticles in combination withgambogic acid for reversing multidrug resistance of K562/A02 cells to daunorubicin
278. Pharmacokinetics and Tissue Distribution Study ofgambogic acid andgambogic acid Nanosuspension in Mice by UHPLC–MS/MS
279. Pharmacokinetics ofgambogic acid in rats
280. Pharmacokinetics, tissue distribution and excretion ofgambogic acid in rats
281. PhaseⅠhuman tolerability trial ofgambogic acid
282. Pluronic F68-linoleic acid nano-spheres mediated delivery ofgambogic acid for cancer therapy
283. Poloxamer 407/TPGS mixed micelles for delivery ofgambogic acid to breast and multidrug-resistant cancer
284. Posttranscriptional regulation of the telomerase hTERT bygambogic acid in human gastric carcinoma 823 cells
285. Potent anti-inflammatory and antiproliferative effects ofgambogic acid in a rat model of antigen-induced arthritis
286. Preparation, physical properties, and stability ofgambogic acid-loaded micelles based on chitosan derivatives
287. Preparative separation ofgambogic acid and its C-2 epimer using recycling high-speed counter-current chromatography
288. Progress in the Effect of Anti-tumor Molecular Targets ofgambogic acid [J]
289. Protective role ofgambogic acid in experimental pulmonary fibrosis in vitro and in vivo
290. Proteomic analysis revealed the important role of vimentin in human cervical carcinoma HeLa cells treated withgambogic acid
291. Proteomic and bioinformatic analyses of possible target-related proteins ofgambogic acid in human breast carcinoma MDA-MB-231 cells
292. Proteomic identification of molecular targets ofgambogic acid: role of stathmin in hepatocellular carcinoma
293. Quantitative cardiotoxicity assessment ofgambogic acid using multiple cellular phenotype analysis
294. Radioiodinated ofgambogic acid and its biodistribution in mice
295. Rational Design of GO-Modified Fe3O4/SiO2 Nanoparticles with Combined Rhenium-188 andgambogic acid for Magnetic Target Therapy
296. Reactive oxygen species accumulation contributes togambogic acid-induced apoptosis in human hepatoma SMMC-7721 cells
297. Redox-responsive polymeric micelles formed by conjugatinggambogic acid with bioreducible poly (amido amine) s for the co-delivery of docetaxel and MMP-9 …
298. Regulation ofgambogic acid on hERG potassium channel protein of K562 leukemia cells [J]
299. Repression of telomerase reverse transcriptase mRNA and hTERT promoter bygambogic acid in human gastric carcinoma cells
300. Research progress ofgambogic acid as active ingredient of traditional Chinese medicine (TCM) gamboge
301. Research progress ofgambogic acid in tumor.
302. Reversal effect ofgambogic acid on multidrug resistance of K562/A02 cell line
303. Role of chloride channels ingambogic acid-induced apoptosis of poorly differentiated nasopharyngeal carcinoma cells
304. Role ofgambogic acid and NaI131 in A549/DDP cells
305. Role ofgambogic acid in Chemosensitization of Cancer
306. ROS-mediated autophagy induced by dysregulation of lipid metabolism plays a protective role in colorectal cancer cells treated withgambogic acid
307. Screening for natural compounds with anticancer activity in colon cancer cells identifies cytotoxicgambogic acid analogues
308. Selective anti-proliferative effect of an anti-transferrin receptor IgG3-avidin fusion protein andgambogic acid in a panel of hematopoietic malignant cell lines
309. Silencing pyruvate kinase M2 sensitizes human prostate cancer PC3 cells togambogic acid-induced apoptosis
310. Simultaneous determination and pharmacokinetic study ofgambogic acid and gambogenic acid in rat plasma after oral administration of Garcinia hanburyi extracts …
311. Single‐walled carbon nanotube and graphene nanodelivery ofgambogic acid increases its cytotoxicity in breast and pancreatic cancer cells
312. Single-walled carbon nanotube and graphene: Nano-delivery ofgambogic acid increases its cytotoxicty in various cancer cells
313. Solubility measurement and RESOLV-assisted nanonization ofgambogic acid in supercritical carbon dioxide for cancer therapy
314. Specific and slow inhibition of the kir2. 1 K+ channel bygambogic acid
315. Spectacular modification ofgambogic acid on microwave irradiation in methanol: Isolation and structure identification of two products with potent anti-tumor activity
316. Stability and cytotoxicity ofgambogic acid and its derivative, gambogoic acid
317. Steroid receptor coactivator-3 is a pivotal target ofgambogic acid in B-cell Non-Hodgkin lymphoma and an inducer of histone H3 deacetylation
318. Structure elucidation of metabolites ofgambogic acid in vivo in rat bile by high-performance liquid chromatography–mass spectrometry and high-performance liquid …
319. Structure-activity relationship ofgambogic acid
320. Studies on chemical modification and biology of a natural product,gambogic acid (III): determination of the essential pharmacophore for biological activity
321. Studies on Chemical Structure Modification and Structure Activity Relationship of Derivatives ofgambogic acid at C (39)
322. Studies on Chemical‐Structure Modification and Structure Activity Relationship ofgambogic acid Derivatives at Carbon (34)
323. Studies ongambogic acid (IV): Exploring structure–activity relationship with IκB kinase-beta (IKKβ)
324. Studies on lactoferrin nanoparticles ofgambogic acid for oral delivery
325. Studies on preparation and stability of human serum albumin nanoparticles containinggambogic acid
326. Studies on the toxicity ofgambogic acid in rats
327. Study of the enhanced anticancer efficacy ofgambogic acid on Capan-1 pancreatic cancer cells when mediated via magnetic Fe3O4 nanoparticles
328. Study ongambogic acid-loaded Polylacticacid Nanoparticles
329. Study ongambogic acid-loaded Polylacticacid Nanoparticles [J]
330. Study on intestinal absorption kinetics ofgambogic acid in rats
331. Study progress on anti-tumor mechanism ofgambogic acid [J]
332. Subcellular localization and activity ofgambogic acid
333. Suppression of APC production during apoptosis of human colorectal cancer cell line SW480 induced bygambogic acid [J]
334. Suppression of NF-κB signaling and P-glycoprotein function bygambogic acid synergistically potentiates adriamycin-induced apoptosis in lung cancer
335. Synergetic effect of functional cadmium–tellurium quantum dots conjugated withgambogic acid for HepG2 cell-labeling and proliferation inhibition
336. Synergistic anti-proliferative effects ofgambogic acid with docetaxel in gastrointestinal cancer cell lines
337. Synergistic effect of 5-fluorouracil withgambogic acid on BGC-823 human gastric carcinoma
338. Synergistic effect of a combination of nanoparticulate Fe3O4 andgambogic acid on phosphatidylinositol 3-kinase/Akt/Bad pathway of LOVO cells
339. Synergistic effect of magnetic nanoparticles of Fe3O4 withgambogic acid on apoptosis of K562 leukemia cells
340. Synthesis and antiangiogenic activity of novelgambogic acid derivatives
341. Synthesis and antitumor activities of structure-related small molecular compounds ofgambogic acid
342. Synthesis and anti-tumor activity of NO-donating derivatives ofgambogic acid
343. Synthesis and Anti‐tumor Evaluation of B‐ring Modified Caged Xanthone Analogues ofgambogic acid
344. Synthesis and Anti-tumor Evaluation of Nitrile-Containinggambogic acid Derivatives
345. Synthesis and Anti‐tumor Evaluation of Novel C‐37 Modified Derivatives ofgambogic acid
346. Synthesis and biological evaluation of novel derivatives ofgambogic acid as anti-hepatocellular carcinoma agents
347. Synthesis and evaluation ofgambogic acid derivatives as antitumor agents. Part III
348. Synthesis of caged 2, 3, 3a, 7a-tetrahydro-3, 6-methanobenzofuran-7 (6H)-ones: Evaluating the minimum structure for apoptosis induction bygambogic acid
349. Systemic study of solvent-assisted active loading ofgambogic acid into liposomes and its formulation optimization for improved delivery
350. Targeting renal cell carcinoma withgambogic acid in combination with sunitinib in vitro and in vivo
351. The combination of proteasome inhibitors bortezomib andgambogic acid triggers synergistic cytotoxicity in vitro but not in vivo
352. The constitution ofgambogic acid
353. The growth inhibitory effect ofgambogic acid on pancreatic cancer cells
354. The natural compoundgambogic acid radiosensitizes nasopharyngeal carcinoma cells under hypoxic conditions
355. The natural interaction betweengambogic acid and oxaliplatin and its probably mechanism
356. The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect ofgambogic acid on oral squamous cell carcinoma
357. The Noncompetitive Effect ofgambogic acid Displaces Fluorescence-Labeled ATP but Requires ATP for Binding to Hsp90/HtpG
358. The nuclear export of TR3 mediatedgambogic acid-induced apoptosis in cervical cancer cells through mitochondrial dysfunction
359. The regulation of neo-ambogic acid on miRNAs for epithelial-mesenchymal transition and drug-resistance of cervical cancer
360. THERAPEUTIC POTENCIAL OFgambogic acid AND SILIBININ IN ACUTE MYELOBLASTIC LEUKEMIA-IN VITRO STUDIES: PB1708
361. Therapeutic Potential ofgambogic acid and Silibinin in Acute Myeloblastic Leukemia–in vitro studies
362. Therapeutic potential ofgambogic acid, a caged xanthone, to target cancer
363. Titania-coated gold nanorods as an effective carrier forgambogic acid
364. Toxicological studies ofgambogic acid and its potential targets in experimental animals
365. Transcriptional Analysis of the Effects ofgambogic acid and Neoambogic acid: Inhibition of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus
366. Triphenylphosphonium-modified poly (ethylene glycol)-poly (ε-caprolactone) micelles for mitochondria-targetedgambogic acid delivery
367. Tumor neovasculature-targeted cationic PEGylated liposomes ofgambogic acid for the treatment of triple-negative breast cancer
368. UHPLC‐MS method for determination ofgambogic acid and application to bioavailability, pharmacokinetics, excretion and tissue distribution in rats
369. UNC119 mediatesgambogic acid-induced cell-cycle dysregulation through the Gsk3β/β-catenin pathway in hepatocellular carcinoma cells
370. Viability inhibition effect ofgambogic acid combined with cisplatin on osteosarcoma cells via mitochondria-independent apoptotic pathway
371. Water-solublegambogic acid PEGylated prodrugs: synthesis, characterization, physicochemical properties and in vitro hydrolysis
372. α-Mangostin andgambogic acid as potential inhibitors of the p53–MDM2 interaction revealed by a yeast approach