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Celastrol
Celastrol
Celastrol (God Vine)
532 Priming of Stem Cells With
celastrol
to Enhance Survival for Cell Therapy
A lipidomics investigation into the intervention of
celastrol
in experimental colitis
A mechanistic overview of triptolide and celastrol, natural products from Tripterygium wilfordii Hook F
A new mechanism of inhibition of IL-1β secretion by
celastrol
through the NLRP3 inflammasome pathway
A novel nucleolin aptamer-
celastrol
conjugate (NACC) with super antitumor activity on advanced pancreatic cancer
AB0096 Efficacy and safety of oral administration of pure
celastrol
in aia rats
Abstract LB-266: Suppression of colitis-associated colon carcinogenesis by the natural triterpenoid celastrol
Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule
Advances in structural modifications of celastrol.
AFM studied the effect of
celastrol
on β1 integrin‐mediated HUVEC adhesion and migration
AFM Study of the
Celastrol
-induced Inhibition on Vein Endothelial Cells [J]
AlCl3· 6H2O-Catalyzed Friedel-Crafts Alkylation of Indoles by the para-Quinone Methide Moiety of
Celastrol
Analysis of
celastrol
in whole blood by high-performance liquid chromatography coupled with mass spectrometry [J]
Antiangiogenic effect of
celastrol
on the growth of human glioma: anin vitroandin vivostudy
Antibacterial activity of
celastrol
against Bacillus subtilis
Anti-biofilm and anti-virulence efficacy of
celastrol
against Stenotrophomonas maltophilia
Anticancer activity of
celastrol
in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers
Anticancer effect of
celastrol
on human triple negative breast cancer: possible involvement of oxidative stress, mitochondrial dysfunction, apoptosis and PI3K/Akt …
Antifungal properties of pristimerin and
celastrol
isolated from Celastrus hypoleucus
Anti-invasive effects of
celastrol
in hypoxia-induced fibroblast-like synoviocyte through suppressing of HIF-1α/CXCR4 signaling pathway
Anti-metastasis of
celastrol
on esophageal cancer cells and its mechanism
Antioxidant effects of
celastrol
against hydrogen peroxide-induced oxidative stress in the cell model of amyotrophic lateral sclerosis
Anti-staphylococcal activity of
celastrol
Antitumor activity of
celastrol
by inhibition of proliferation, invasion, and migration in cholangiocarcinoma via PTEN/PI3K/Akt pathway
Antitumor activity of
celastrol
nanoparticles in a xenograft retinoblastoma tumor model
Antitumor effects of
celastrol
and semi-synthetic derivatives
Apoptosis induced by
celastrol
on multiple cell lines and the effect on cell cycle [J]
Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene
celastrol
ATF2 contributes to cisplatin resistance in non‐small cell lung cancer and
celastrol
induces cisplatin resensitization through inhibition of JNK/ATF2 pathway
Attenuation of muscle atrophy by triterpentene
celastrol
Autophagic degradation of epidermal growth factor receptor in gefitinib-resistant lung cancer by
celastrol
Autophagy flux inhibition mediated by
celastrol
sensitized lung cancer cells to TRAIL‑induced apoptosis via regulation of mitochondrial transmembrane …
Autophagy induction by
celastrol
augments protection against bleomycin-induced experimental pulmonary fibrosis in rats: Role of adaptor protein p62/SQSTM1
Axl is a novel target of
celastrol
that inhibits cell proliferation and migration, and increases the cytotoxicity of gefitinib in EGFR mutant non‑small cell lung cancer cells
Beta-catenin mediates the apoptosis induction effect of
celastrol
in HT29 cells
Biological activity of the triterpene
celastrol
, analysis from the viewpoint of the apoptosis induction
C57 CELLULAR/MOLECULAR MECHANISMS AND TRANSLATIONAL ASPECTS OF RESPIRATORY INFECTIONS:
celastrol
Promotes Granulocyte Differentiation …
Ca2+ signalling plays a role in
celastrol
‐mediated suppression of synovial fibroblasts of rheumatoid arthritis patients and experimental arthritis in rats
Cancerous inhibitor of PP2A is targeted by natural compound
celastrol
for degradation in non-small-cell lung cancer
Cascade regulation of PPARγ2 and C/EBPα signaling pathways by
celastrol
impairs adipocyte differentiation and stimulates lipolysis in 3T3-L1 adipocytes
Celastrol
celastrol
& Triptolide from Tripterygium Wilfordii Powerful Anti-Cancer Treatments?
celastrol
acts as a potent antimetastatic agent targeting β1 integrin and inhibiting cell-extracellular matrix adhesion, in part via the p38 mitogen-activated protein …
celastrol
aggravates LPS-induced inflammation and injuries of liver and kidney in mice
celastrol
alleviates airway hyperresponsiveness and inhibits Th17 responses in obese asthmatic mice
celastrol
Alleviates Airway Hyperresponsiveness by Downregulating Th17 in Obese Asthmatic Mice
celastrol
alleviates angiotensin II‑mediated vascular smooth muscle cell senescence via induction of autophagy
celastrol
Alleviates Aortic Valve Calcification Via Inhibition of NADPH Oxidase 2 in Valvular Interstitial Cells
celastrol
alleviates arthritis by modulating the inflammatory activities of neutrophils
celastrol
Alleviates Chronic Obstructive Pulmonary Disease by Inhibiting Cellular Inflammation Induced by Cigarette Smoke via the Ednrb/Kng1 Signaling Pathway
celastrol
alleviates renal fibrosis by upregulating cannabinoid receptor 2 expression
celastrol
ameliorates acetaminophen-induced oxidative stress and cytotoxicity in HepG2 cells
celastrol
ameliorates Aspergillus fumigatus keratitis via inhibiting LOX-1
celastrol
ameliorates Cd‐induced neuronal apoptosis by targeting NOX2‐derived ROS‐dependent PP5‐JNK signaling pathway
celastrol
ameliorates cisplatin nephrotoxicity by inhibiting NF-κB and improving mitochondrial function
celastrol
ameliorates cytokine toxicity and pro-inflammatory immune responses by suppressing NF-κB activation in RINm5F beta cells
celastrol
ameliorates EAE induction by suppressing pathogenic T cell responses in the peripheral and central nervous systems
celastrol
ameliorates experimental colitis in IL-10 deficient mice via the up-regulation of autophagy
celastrol
ameliorates HIV-1 Tat-induced inflammatory responses via NF-kappaB and AP-1 inhibition and heme oxygenase-1 induction in astrocytes
celastrol
Ameliorates Inflammation in Human Retinal Pigment Epithelial Cells by Suppressing NF-κB Signaling
celastrol
ameliorates inflammation through inhibition of NLRP3 inflammasome activation
celastrol
ameliorates inflammatory pain and modulates HMGB1/NF-κB signaling pathway in dorsal root ganglion
celastrol
ameliorates liver metabolic damage caused by a high-fat diet through Sirt1
celastrol
ameliorates murine colitis via modulating oxidative stress, inflammatory cytokines and intestinal homeostasis
celastrol
ameliorates ulcerative colitis-related colorectal cancer in mice via suppressing inflammatory responses and epithelial-mesenchymal transition
celastrol
analogues as inducers of the heat shock response. Design and synthesis of affinity probes for the identification of protein targets
celastrol
and an EGCG pro-drug exhibit potent chemosensitizing activity in human leukemia cells
celastrol
and attenuation of tumor growth in systemic malignancies: a clinical perspective
celastrol
and its role in controlling chronic diseases
celastrol
and terpenes as anti-infective agents
celastrol
antagonizes high glucose-evoked podocyte injury, inflammation and insulin resistance by restoring the HO-1-mediated autophagy pathway
celastrol
as a Novel Cardioprotective Drug
celastrol
as a pentacyclic triterpenoid with chemopreventive properties
celastrol
as a tool for the study of the biological events of metabolic diseases
celastrol
attenuates adipokine resistin‐associated matrix interaction and migration of vascular smooth muscle cells
celastrol
attenuates angiotensin II mediated human umbilical vein endothelial cells damage through activation of Nrf2/ERK1/2/Nox2 signal pathway
celastrol
attenuates atherosclerosis in Apolipoprotein E (apoE) knockout mice fed an atherogenic diet
celastrol
attenuates bone erosion in collagen-Induced arthritis mice and inhibits osteoclast differentiation and function in RANKL-induced RAW264. 7
celastrol
Attenuates Cadmium‐Induced Neuronal Apoptosis via Inhibiting Ca2+‐CaMKII‐Dependent Akt/mTOR Pathway
celastrol
attenuates fMLP-induced superoxide anion generation, myeloperoxidase production, and elastase release by human neutrophils
celastrol
attenuates hypertension-induced inflammation and oxidative stress in vascular smooth muscle cells via induction of heme oxygenase-1
celastrol
attenuates impairments associated with lipopolysaccharide-induced acute respiratory distress syndrome (ARDS) in rats
celastrol
attenuates incision-induced inflammation and pain associated with inhibition of the NF-κB signalling pathway via SARM
celastrol
attenuates inflammatory and neuropathic pain mediated by cannabinoid receptor type 2
celastrol
Attenuates Intrahepatic Cholestasis of Pregnancy by Inhibiting Matrix Metalloproteinases-2 and 9
celastrol
attenuates mitochondrial dysfunction and inflammation in palmitate-mediated insulin resistance in C3A hepatocytes
celastrol
attenuates multiple sclerosis and optic neuritis in an experimental autoimmune encephalomyelitis model
celastrol
attenuates oxidative stress in the skeletal muscle of diabetic rats by regulating the AMPK-PGC1α-SIRT3 signaling pathway
celastrol
attenuates ox-LDL-induced mesangial cell proliferation via suppressing NLRP3 inflammasome activation
celastrol
attenuates pain and cartilage damage via SDF‐1/CXCR 4 signalling pathway in osteoarthritis rats
celastrol
attenuates renal injury in diabetic rats via MAPK/NF‐κB pathway
celastrol
attenuates symptoms of preeclampsia in rats by inhibiting matrix metalloproteinase-9
celastrol
attenuates the invasion and migration and augments the anticancer effects of bortezomib in a xenograft mouse model of multiple myeloma
celastrol
attenuates ventilator induced lung injury in mouse through inhibition of MAPK pathway
celastrol
binds to ERK and inhibits FcεRI signaling to exert an anti-allergic effect
celastrol
Binds to HSP90 Trigger Functional Protein Interaction Network Against Pancreatic Cancer
celastrol
binds to its target protein via specific noncovalent interactions and reversible covalent bonds
celastrol
blocks binding of lipopolysaccharides to a Toll-like receptor4/myeloid differentiation factor2 complex in a thiol-dependent manner
celastrol
blocks interleukin-6 gene expression via downregulation of NF-κB in prostate carcinoma cells
celastrol
blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis
celastrol
can inhibit proteasome activity and upregulate the expression of heat shock protein genes, hsp30 and hsp70, in Xenopus laevis A6 cells
celastrol
causes apoptosis and cell cycle arrest in rat glioma cells
celastrol
could protect the INS-1from functional impairment
celastrol
Decreases Endoplasmic Reticulum (ER) Stress and Clinical Progression in the Cx3cr1-/-/Ccl2-/-Murine Model of Age-Related Macular Degeneration
celastrol
decreases specificity proteins (Sp) and fibroblast growth factor receptor-3 (FGFR3) in bladder cancer cells
celastrol
delays hepatic steatosis and carcinogenesis in a rapid AKT/c-Met-transfected hepatocellular carcinoma model via suppressing fatty acid synthase …
celastrol
downregulates E2F1 to induce growth inhibitory effects in hepatocellular carcinoma HepG2 cells
celastrol
down-regulates expression of P-Akt and cyclin D1 in HL-60 cells and induces apoptosis
celastrol
down-regulates expressions of MIF and MMP-9 in the aorta of ApoE gene knockout mice
celastrol
down-regulates expressions of MIF and MMP-9 in the aorta of ApoE gene knockout mice [J]
celastrol
enhanced the anticancer effect of lapatinib in human hepatocellular carcinoma cells in vitro
celastrol
enhances AAV1-mediated gene expression in mice adipose tissues
celastrol
enhances Atoh1 expression in inner ear stem cells and promotes their differentiation into functional auditory neuronal-like cells
celastrol
enhances cell viability and inhibits amyloid-β production induced by lipopolysaccharide in vitro
celastrol
enhances Nrf2 mediated antioxidant enzymes and exhibits anti-fibrotic effect through regulation of collagen production against bleomycin-induced …
celastrol
Enhances the Anti-Liver Cancer Activity of Sorafenib
celastrol
enhances TRAIL-induced apoptosis in human glioblastoma via the death receptor pathway
celastrol
exerts anti‐inflammatory effect in liver fibrosis via activation of AMPK‐SIRT3 signalling
celastrol
exerts synergistic effects with PHA-665752 and inhibits tumor growth of c-Met-deficient hepatocellular carcinoma in vivo
celastrol
from ‘Thunder God Vine’protects SH-SY5Y cells through the preservation of mitochondrial function and inhibition of p38 MAPK in a rotenone model of …
celastrol
identified as a leptin sensitizer and potential novel treatment for obesity
celastrol
improves self-renewal and differentiation of human tendon-derived stem cells by suppressing Smad7 through hypoxia
celastrol
improves the therapeutic efficacy of EGFR-TKIs for non-small-cell lung cancer by overcoming EGFR T790M drug resistance
celastrol
in the inhibition of neovascularization
celastrol
increases glucocerebrosidase activity in Gaucher disease by modulating molecular chaperones
celastrol
increases osteosarcoma cell lysis by γδ T cells through up-regulation of death receptors
celastrol
induce apoptosis of human multiple myeloma cells involving inhibition of proteasome activity
celastrol
induced cell cycle arrest in Her2/neu-overexpressing MDA-MB-453 cancer cells and its mechanisms
celastrol
induced DNA damage, cell cycle arrest, and apoptosis in human rheumatoid fibroblast-like synovial cells
celastrol
induces apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells: an in vitro and in vivo study
celastrol
induces apoptosis in gefitinib-resistant non-small cell lung cancer cells via caspases-dependent pathways and Hsp90 client protein degradation
celastrol
induces apoptosis in hepatocellular carcinoma cells via targeting ER-stress/UPR
celastrol
induces apoptosis in human colon cancer SW620 cells through species reactive oxygen
celastrol
induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria-and Fas/FasL-mediated pathways
celastrol
induces apoptosis of gastric cancer cells by miR-146a inhibition of NF-κB activity
celastrol
induces apoptosis of gastric cancer cells by miR-21 inhibiting PI3K/Akt-NF-κB signaling pathway
celastrol
induces apoptosis of human osteosarcoma cells via the mitochondrial apoptotic pathway
celastrol
induces apoptosis through modulation of estrogen receptor in human breast cancer cells
celastrol
induces autophagy by targeting AR/miR-101 in prostate cancer cells
celastrol
induces caspase-dependent apoptosis through ROS/JNK path-way in Saos-2 cells
celastrol
induces cell apoptosis and inhibits the expression of the AML1-ETO/C-KIT oncoprotein in t (8; 21) leukemia
celastrol
induces cell cycle arrest by MicroRNA-21-mTOR-mediated inhibition p27 protein degradation in gastric cancer
celastrol
induces expression of heme oxygenase-1 through ROS/Nrf2/ARE signaling in the HaCaT cells
celastrol
induces mitochondria-mediated apoptosis in hepatocellular carcinoma Bel-7402 cells
celastrol
Induces Necroptosis and Ameliorates Inflammation via Targeting Biglycan in Human Gastric Carcinoma
celastrol
induces paraptosis-like cell death via mitochondrial Ca2+ overload in breast cancer cells
celastrol
induces proteasomal degradation of FANCD 2 to sensitize lung cancer cells to DNA crosslinking agents
celastrol
induces the apoptosis of breast cancer cells and inhibits their invasion via downregulation of MMP-9
celastrol
induces ubiquitin-dependent degradation of mTOr in breast cancer cells
celastrol
induces unfolded protein response-dependent cell death in head and neck cancer
celastrol
induces vincristine multidrug resistance oral cancer cell apoptosis by targeting JNK1/2 signaling pathway
celastrol
inhibits aminoglycoside-induced ototoxicity via heat shock protein 32
celastrol
Inhibits Breast Cancer Cell Invasion via Suppression of NF-ĸB-mediated Matrix Metalloproteinase-9 Expression
celastrol
inhibits breast cancer cell invasion via suppression of NF-ĸB-mediated matrix metalloproteinase-9 expression.
celastrol
inhibits cancer metastasis by suppressing M2-like polarization of macrophages
celastrol
inhibits chondrosarcoma proliferation, migration and invasion through suppression CIP2A/c-MYC signaling pathway
celastrol
inhibits colon cancer cell proliferation by downregulating miR-21 and PI3K/AKT/GSK-3β pathway
celastrol
inhibits colorectal cancer cell proliferation and migration through suppression of MMP3 and MMP7 by the PI3K/AKT signaling pathway
celastrol
inhibits colorectal cancer through TgF-β1/smad signaling
celastrol
inhibits dengue virus replication via up-regulating type I interferon and downstream interferon-stimulated responses
celastrol
Inhibits Dopaminergic Neuronal Death of Parkinson’s Disease through Activating Mitophagy
celastrol
inhibits gastric cancer growth by induction of apoptosis and autophagy
celastrol
inhibits glucocorticoid‑induced osteoporosis in rat via the PI3K/AKT and Wnt signaling pathways
celastrol
inhibits growth and increases apoptosis of human lung cancer A549 cells
celastrol
inhibits growth and induces apoptotic cell death in melanoma cells via the activation ROS-dependent mitochondrial pathway and the suppression of PI3K …
celastrol
inhibits growth and metastasis of human gastric cancer cell MKN45 by down‐regulating microRNA‐21
celastrol
inhibits hepatitis C virus replication by upregulating heme oxygenase-1 via the JNK MAPK/Nrf2 pathway in human hepatoma cells
celastrol
inhibits high fat diet-induced obesity and intestinal tumorigenesis in APCMin/+ mice by modulating gut microbes and inflammation
celastrol
inhibits Hsp90 and triggers ER stress-induced cell death in non-small cell lung cancer cells
celastrol
inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23
celastrol
inhibits human glioma xenograft
celastrol
Inhibits Hypoxia-Inducible Factor-1α Activation in Hepatocellular Carcinoma Cells
celastrol
inhibits IL-1β-induced inflammation in orbital fibroblasts through the suppression of NF-κB activity
celastrol
inhibits inflammatory stimuli-induced neutrophil extracellular trap formation
celastrol
inhibits interleukin-17A-stimulated rheumatoid fibroblast-like synoviocyte migration and invasion through suppression of NF-κB-mediated matrix …
celastrol
inhibits lipopolysaccharide-induced angiogenesis by suppressing TLR4-triggered nuclear factor-kappa B activation
celastrol
inhibits lipopolysaccharide-stimulated rheumatoid fibroblast-like synoviocyte invasion through suppression of TLR4/NF-κB-mediated matrix …
celastrol
inhibits lung infiltration in differential syndrome animal models by reducing TNF-α and ICAM-1 levels while preserving differentiation in ATRA …
celastrol
inhibits microglial pyroptosis and attenuates inflammatory reaction in acute spinal cord injury rats
celastrol
inhibits migration and invasion through blocking the NF‑κB pathway in ovarian cancer cells
celastrol
inhibits migration, proliferation and transforming growth factor-β2-induced epithelial-mesenchymal transition in lens epithelial cells
celastrol
inhibits Plasmodium falciparum enoyl-acyl carrier protein reductase
celastrol
inhibits polyglutamine aggregation and toxicity though induction of the heat shock response
celastrol
inhibits production of nitric oxide and proinflammatory cytokines through MAPK signal transduction and NF-κB in LPS-stimulated BV-2 microglial cells
celastrol
inhibits pro-inflammatory cytokine secretion in Crohn’s disease biopsies
celastrol
inhibits proliferation and induces chemosensitization through down‐regulation of NF‐κB and STAT3 regulated gene products in multiple myeloma cells
celastrol
inhibits prostaglandin E2-induced proliferation and osteogenic differentiation of fibroblasts isolated from ankylosing spondylitis hip tissues in vitro
celastrol
inhibits Tat-mediated human immunodeficiency virus (HIV) transcription and replication
celastrol
inhibits TGF-β1-induced epithelial–mesenchymal transition by inhibiting Snail and regulating E-cadherin expression
celastrol
inhibits the growth of estrogen positive human breast cancer cells through modulation of estrogen receptor α
celastrol
inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression
celastrol
inhibits the growth of ovarian Cancer cells in vitro and in vivo
celastrol
inhibits the HIF-1α pathway by inhibition of mTOR/p70S6K/eIF4E and ERK1/2 phosphorylation in human hepatoma cells
celastrol
inhibits the secretion of interleukin-17 in peripheral blood mononuclear cells in patients with sympathetic ophthalmia
celastrol
inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways
celastrol
inhibits vasculogenesis by suppressing the VEGF-induced functional activity of bone marrow-derived endothelial progenitor cells
celastrol
is a novel selective agonist of cannabinoid receptor 2 with anti-inflammatory and anti-fibrotic activity in a mouse model of systemic sclerosis
celastrol
isolated from Tripterygium regelii induces apoptosis through both caspase-dependent and-independent pathways in human breast cancer cells
celastrol
Limits Autoimmune Arthritis by Reducing Th17 and Promoting Treg Cells in Inflamed Joints
celastrol
may have an anti-atherosclerosis effect in a rabbit experimental carotid atherosclerosis model
celastrol
Mediated Hsp90 Protein Inhibition in Cancer
celastrol
mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells
celastrol
mediates Th17 and Treg cell generation via metabolic signaling
celastrol
modulated Taz and induced cell apoptosis in vitro
celastrol
modulates inflammation through inhibition of the catalytic activity of mediators of arachidonic acid pathway: Secretory phospholipase A2 group IIA, 5 …
celastrol
Modulates inflammatory Responses in Retinal Pigment Epithelial Cells (RPE)
celastrol
Modulates Lipid Synthesis via PI3K/Akt/mTOR Signaling Axis to finalize Cell Death Response in Prostate Cancer Cells
celastrol
nanomicelles attenuate cytokine secretion in macrophages and inhibit macrophage-induced corneal neovascularization in rats
celastrol
nanoparticles inhibit corneal neovascularization induced by suturing in rats
celastrol
negatively regulates cell invasion and migration ability of human osteosarcoma via downregulation of the PI3K/Akt/NF-κB signaling pathway in vitro
celastrol
overcomes HSP72 gene silencing-mediated muscle atrophy and induces myofiber preservation
celastrol
potentiates radiotherapy by impairment of DNA damage processing in human prostate cancer
celastrol
preserves bone structure and mechanics in arthritic rats
celastrol
pretreatment as a therapeutic option against cisplatin-induced nephrotoxicity
celastrol
pretreatment attenuates rat myocardial ischemia/reperfusion injury by inhibiting high mobility group box 1 protein expression via the PI3K/Akt pathway
celastrol
PREVENTS ADVERSE CARDIAC REMODELING OF THE ISCHEMIC MYOCARDIUM
celastrol
prevents atherosclerosis via inhibiting LOX-1 and oxidative stress
celastrol
prevents cadmium‐induced neuronal cell death by blocking reactive oxygen species‐mediated mammalian target of rapamycin pathway
celastrol
prevents cadmium‐induced neuronal cell death via targeting JNK and PTEN‐Akt/mTOR network
celastrol
prevents circulatory failure via induction of heme oxygenase-1 and heat shock protein 70 in endotoxemic rats
celastrol
Promotes Granulocyte Differentiation To Protect Against Bacteria
celastrol
Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus
celastrol
protects against antimycin A-induced insulin resistance in human skeletal muscle cells
celastrol
PROTECTS AGAINST ISCHEMIA/REPERFUSION-INDUCED CARDIAC CELL DEATH
celastrol
protects against MPTP‐and 3‐nitropropionic acid‐induced neurotoxicity
celastrol
protects against obesity and metabolic dysfunction through activation of a HSF1-PGC1α transcriptional axis
celastrol
protects from cholestatic liver injury through modulation of SIRT1-FXR signaling
celastrol
protects human neuroblastoma SH-SY5Y cells from rotenone-induced injury through induction of autophagy
celastrol
protects human retinal pigment epithelial cells against hydrogen peroxide mediated oxidative stress, autophagy, and apoptosis through sirtuin 3 signal …
celastrol
protects kidney against ischemia–reperfusion-induced injury in rats
celastrol
protects mouse retinas from bright light-induced degeneration through inhibition of oxidative stress and inflammation
celastrol
Protects Retinal Ganglion Cells from Optic Nerve Crush but not from Glaucomatous Damage
celastrol
Protects RPE Cells from Oxidative Stress-Induced Cell Death via Activation of Nrf2 Signaling Pathway
celastrol
protects TGF-β1-induced endothelial-mesenchymal transition
celastrol
Reduces Airway Hypersensitivity and Lung Tissue Remodeling Via Regulating the Production of MMP-2/9 in Mouse Allergic Asthma Model.
celastrol
reduces IL-1β induced matrix catabolism, oxidative stress and inflammation in human nucleus pulposus cells and attenuates rat intervertebral disc …
celastrol
Reduces Obesity in MC4R Deficiency and Stimulates Sympathetic Nerve Activity Affecting Metabolic and Cardiovascular Functions
celastrol
Regulates Innate Immunity Response Via Nf-B And Hsp70 In Human Retinal Pigment Epithelial Cells
celastrol
regulates innate immunity response via NF‐kB and HSP70 in ARPE‐19 cells
celastrol
regulates innate immunity response via NF-κB and Hsp70 in human retinal pigment epithelial cells
celastrol
regulates multiple nuclear transcription factors belonging to HSP90’s clients in a dose-and cell type-dependent way
celastrol
reverses palmitic acid (PA)‐caused TLR4‐MD2 activation‐dependent insulin resistance via disrupting MD2‐related cellular binding to PA
celastrol
Reverses Palmitic Acid-Induced Insulin Resistance in HepG2 Cells via Restoring the miR-223 and GLUT4 Pathway
celastrol
shows chemopreventive properties in an inflammatory driven model for colon cancer via induction of Nrf2 transcription.
celastrol
stimulates hypoxia-inducible factor-1 activity in tumor cells by initiating the ROS/Akt/p70S6K signaling pathway and enhancing hypoxia-inducible …
celastrol
strongly inhibits proliferation, migration and cancer stem cell properties through suppression of Pin1 in ovarian cancer cells
celastrol
supports survival of retinal ganglion cells injured by optic nerve crush
celastrol
suppresses allergen-induced airway inflammation in a mouse allergic asthma model
celastrol
suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway
celastrol
suppresses breast cancer MCF-7 cell viability via the AMP-activated protein kinase (AMPK)-induced p53–polo like kinase 2 (PLK-2) pathway
celastrol
suppresses experimental autoimmune encephalomyelitis via MAPK/SGK1-regulated mediators of autoimmune pathology
celastrol
suppresses expression of adhesion molecules and chemokines by inhibiting JNK-STAT1/NF-κB activation in poly (I: C)-stimulated astrocytes
celastrol
suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade in vitro and in vivo
celastrol
suppresses IFN-gamma-induced ICAM-1 expression and subsequent monocyte adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells
celastrol
suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor
celastrol
suppresses morphological and transcriptional responses in microglial cells upon stimulation with double-stranded RNA
celastrol
suppresses nitric oxide synthases and the angiogenesis pathway in colorectal cancer
celastrol
suppresses obesity process via increasing antioxidant capacity and improving lipid metabolism
celastrol
suppresses the proliferation of lung adenocarcinoma cells by regulating microRNA-24 and microRNA-181b
celastrol
Suppresses Tryptophan Catabolism in Human Colon Cancer Cells as Revealed by Metabolic Profiling and Targeted Metabolite Analysis
celastrol
suppresses tumor cell growth through targeting an AR-ERG-NF-κB pathway in TMPRSS2/ERG fusion gene expressing prostate cancer
celastrol
synergistically enhances temozolomide cytotoxicity in melanoma cells
celastrol
synergizes with oral nifedipine to attenuate hypertension in preeclampsia: a randomized, placebo-controlled, and double blinded trial
celastrol
targets IRAKs to block Toll-like receptor 4-mediated nuclear factor-κB activation
celastrol
targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent cytotoxicity in tumor cells
celastrol
targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells
celastrol
treatment protects against acute ischemic stroke-induced brain injury by promoting an IL-33/ST2 axis-mediated microglia/macrophage M2 …
Celastrol
, a Chinese herbal compound, controls autoimmune inflammation by altering the balance of pathogenic and regulatory T cells in the target organ
Celastrol
, a novel HSP90 inhibitor, depletes Bcr–Abl and induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation
Celastrol
, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κB–regulated gene products and TAK1 …
Celastrol
, a plant-derived triterpene, induces cisplatin-resistance nasopharyngeal carcinoma cancer cell apoptosis though ERK1/2 and p38 MAPK signaling pathway
Celastrol
, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer’s disease
Celastrol
, a proteasome inhibitor, can induce the expression of heat shock protein genes in Xenopus cultured cells
Celastrol
, a proteasome inhibitor, can induce the expression of heat shock protein genes in Xenopus laevis A6 kidney epithelial cells
Celastrol
, a triterpene extracted from the Chinese “Thunder of God Vine,” is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice
Celastrol
, a triterpene extracted from Tripterygium wilfordii Hook F, inhibits platelet activation
Celastrol
, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors
Celastrol
, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors.
Celastrol
, a unique multifunctional pharmacophore with multiple targets as an effective therapeutic against ErbB2-overexpressing cancers
Celastrol
, an active constituent of the TCM plant Tripterygium wilfordii Hook.f., inhibits prostate cancer bone metastasis
Celastrol
, an active constituent of the TCM plant Tripterygium wilfordii, inhibits prostate cancer bone metastasis
Celastrol
, an active ingredient in Chinese herbal medicine, radiosensitizes human prostate cancer via modulating NF-kB-signaling pathway
Celastrol
, an inhibitor of heat shock protein 90β potently suppresses the expression of matrix metalloproteinases, inducible nitric oxide synthase and cyclooxygenase …
Celastrol
, an NF-κB inhibitor, ameliorates hypercalciuria and articular cartilage lesions in a mouse model of secondary osteoporosis
Celastrol
, an NF-κB inhibitor, improves insulin resistance and attenuates renal injury in db/db mice
Celastrol
, an oral heat shock activator, ameliorates multiple animal disease models of cell death
Celastrol
, produced by Tripterygium wilfordii Hook F. enhances defense response in cucumber seedlings against diverse environmental stresses
Celastrol
: a new therapeutic potential of traditional Chinese medicine
Celastrol
: a spectrum of treatment opportunities in chronic diseases
Celastrol
: molecular targets of thunder god vine
Celastrol
-based nanomedicines as modulators of neuroinflammation
Celastrol
-induced apoptosis in human HaCaT keratinocytes involves the inhibition of NF-κB activity
Celastrol
-induced apoptosis in human nasopharyngeal carcinoma is associated with the activation of the death receptor and the mitochondrial pathway
Celastrol
-induced degradation of FANCD2 sensitizes pediatric high-grade gliomas to the DNA-crosslinking agent carboplatin
Celastrol
-induced Nur77 interaction with TRAF2 alleviates inflammation by promoting mitochondrial ubiquitination and autophagy
Celastrol
-induced suppression of the MiR-21/ERK signalling pathway attenuates cardiac fibrosis and dysfunction
Celastrol
-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1
Celastrol
-loaded PEG-b-PPS nanocarriers as an anti-inflammatory treatment for atherosclerosis
Celastrol
-loaded PEG-PCL nanomicelles ameliorate inflammation, lipid accumulation, insulin resistance and gastrointestinal injury in diet-induced obese mice
Celastrol
-modified TiO 2 nanoparticles: effects of
celastrol
on the particle size and visible-light photocatalytic activity
Celastrol
-type HSP90 modulators allow for potent cardioprotective effects
Celastrus and its bioactive
celastrol
protect against bone damage in autoimmune arthritis by modulating osteoimmune cross-talk
Celastrus-derived
celastrol
suppresses autoimmune arthritis by modulating antigen-induced cellular and humoral effector responses
Central nervous system effects of
celastrol
, a potent antioxidant and antiinflammatory agent
Characterization of
celastrol
to inhibit hsp90 and cdc37 interaction
Chemopreventive activity of
celastrol
in drug–resistant human colon carcinoma cell cultures
Chronic inhibition of cardiac Kir2. 1 and HERG potassium channels by
celastrol
with dual effects on both ion conductivity and protein trafficking
Co-Administration of
celastrol
Can Induce Possible Elevation of Plasma Concentration of Zidovudin (AZT)
Comparative proteome analysis of celastrol-treated Helicobacter pylori
Competitive profiling of
celastrol
targets in human cervical cancer HeLa cells via quantitative chemical proteomics
Computational investigation of interactions between Cdc37 and celastrol
Control of autoimmune inflammation by
celastrol
, a natural triterpenoid
Correction to Regiochemistry Discoveries in the Use of Isoxazole as a Handle for the Rapid Construction of an All-Carbon Macrocyclic Precursor in the Synthetic Studies of Celastrol
Correction to:
celastrol
mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells
Correction:
celastrol
Suppresses Angiogenesis-Mediated Tumor Growth through Inhibition of AKT/Mammalian Target of Rapamycin Pathway
CYP450s-Activity Relations of
celastrol
to Interact with Triptolide Reveal the Reasons of Hepatotoxicity of Tripterygium wilfordii
Cytotoxic effect of
celastrol
alone or in combination with paclitaxel on anaplastic thyroid carcinoma cells
Decrease of CD68 synovial macrophages in
celastrol
treated arthritic rats
Design and synthesis of
celastrol
derivatives as anticancer agents
Design and synthesis of novel
celastrol
derivative and its antitumor activity in hepatoma cells and antiangiogenic activity in zebrafish
Design, synthesis and antitumor evaluation of novel
celastrol
derivatives
Design, synthesis and biological evaluation of C (6)-modified
celastrol
derivatives as potential antitumor agents
Design, synthesis and biological evaluation of novel C-29 carbamate
celastrol
derivatives as potent and selective cytotoxic compounds
Determination of
celastrol
by lanthanide sensitized fluorescence quenching on terbium-ciprofloxacin-SDS.
Development of B Cells and Erythrocytes Is Specifically Impaired by the Drug
celastrol
in
Development of B cells and erythrocytes is specifically impaired by the drug
celastrol
in mice
Direct inhibition of c-Myc-Max heterodimers by
celastrol
and celastrol-inspired triterpenoids
Discovery of Novel
celastrol
Derivatives as Hsp90–Cdc37 Interaction Disruptors with Antitumor Activity
Discovery of novel NO-releasing
celastrol
derivatives with Hsp90 inhibition and cytotoxic activities
Dissecting
celastrol
with machine learning to unveil dark pharmacology
Docking and molecular dynamics simulations of
celastrol
binding to p23
Downregulation and subcellular distribution of HER2 involved in MDA-MB-453 breast cancer cell apoptosis induced by lapatinib/
celastrol
combination
Downregulation of miR-17-92a cluster promotes autophagy induction in response to
celastrol
treatment in prostate cancer cells
Drug Metabolizing enzymes inhibition-based prediction of celastrol-drugs interaction
EAPH-12.
celastrol
INDUCED DEGRADATION OF FANCD2 SENSITIZES PEDIATRIC HIGH-GRADE GLIOMA TO THE DNA-CROSSLINKING AGENT …
Early
celastrol
Administration Prevents Ketamine-Induced Psychotic-Like Behavioral Dysfunctions, Oxidative Stress and IL-10 Reduction in The Cerebellum of Adult …
Effect and Mechanism of
celastrol
on the Renal Clear Cell Carcinoma 786-0 Cells
Effect and mechanisms of
celastrol
on the apoptosis of HOS osteosarcoma cells
Effect of
celastrol
in inhibiting metastasis of lung cancer cells by influencing Akt signaling pathway and expressing integrins
Effect of
celastrol
in leukocytes from rheumatoid arthritis patients
Effect of
celastrol
on Akt signaling pathway and apoptosis of leukemic K562 cell line
Effect of
celastrol
on bone structure and mechanics in arthritic rats
Effect of
celastrol
on cell cycle arrest and angiogenesis of human multiple myeloma LP-1 cells in vitro [J]
Effect of
celastrol
on differentiation and maturation of CD_ (14)~+ monocyte-derived dendritic cells
Effect of
celastrol
on growth inhibition of prostate cancer cells through the regulation of hERG channel in vitro
Effect of
celastrol
on phagocytosis of neutrophils
Effect of
celastrol
on temozolomide cytotoxicity in melanoma cells and inhibition of NF-kB signaling
Effect of
celastrol
on the progression of polycystic kidney disease in a Pkd1-deficient mouse model
Effect of
celastrol
on toll‑like receptor 4‑mediated inflammatory response in free fatty acid‑induced HepG2 cells
Effect of
celastrol
postconditioning on focal cerebral ischemia-reperfusion injury in rats
Effective treatment of rat adjuvant-induced arthritis by
celastrol
Effects and Mechanisms of
celastrol
(CSL) on Human Colon Cancer Cell Line HCT-116 in vitro [J]
Effects of
celastrol
in a mouse model of pulmonary hypertension associated with bronchopulmonary dysplasia induced by hyperoxia
Effects of
celastrol
on Accelerated Healing of Skin Wounds of Diabetic Ulceration in Rats and Mechanism Revealed by Nuclear Magnetic Resonance-based …
Effects of
celastrol
on Bv-2 Microglial Cells Exposed to in Vitro Hypoxia
Effects of
celastrol
on enhancing apoptosis of ovarian cancer cells via the downregulation of microRNA‑21 and the suppression of the PI3K/Akt‑NF‑κB …
Effects of
celastrol
on human cervical cancer cells as revealed by ion-trap gas chromatography–mass spectrometry based metabolic profiling
EFFECTS OF
celastrol
ON IL-1 AND lL-2 PRODUCTION
Effects of
celastrol
on Tau hyperphosphorylation and expression of HSF‐1 and HSP70 in SH‐SY5Y neuroblastoma cells induced by amyloid‐β peptides
Effects of
celastrol
on the Collagen, Macrophage Migration Inhibitory Factor and Matrix Metalloproteinase-9 Expressions in the Plaque of ApoE Gene Knockout Mice …
Effects of
celastrol
on the expression of CD40 ligand and number of macrophages and smooth muscle cells in the atherosclerotic plaques of ApoE gene knockout …
Effects of
celastrol
on the Expression of C-reactive Protein and Tissue Factor in the Aorta of ApoE Gene Knockout Mice [J]
Effects of demethylzeylasteral and
celastrol
on spermatogenic cell Ca2+ channels and progesterone-induced sperm acrosome reaction
Effects of diclofenac on the pharmacokinetics of
celastrol
in rats and its transport
Effects of environmental stresses on
celastrol
contents in Tripterygium wilfordii.
Efficacy and toxicity evaluation of
celastrol
in adjuvant-induced arthritis rat model
Efficacy of
celastrol
combined with cisplatin in enhancing the apoptosis of U‑2OS osteosarcoma cells via the mitochondrial and endoplasmic reticulum …
Efficacy, pharmacokinetics and tissue distribution of
celastrol
analogues SBI 064601, SBI 0640599 and SBI 0069272 in CB-17 SCID mice bearing Daudi Burkitt’s …
Elucidation of the intestinal absorption mechanism of
celastrol
using the Caco-2 cell transwell model
Enhanced Autophagy by
celastrol
Supplementation Profoundly Increases Angiotensin II-induced Abdominal Aortic Aneurysm Formation in Male and Female Mice
Enhanced cancer therapy of
celastrol
in vitro and in vivo by smart dendrimers delivery with specificity and biosafety
Enhancement of radiation sensitivity in lung cancer cells by
celastrol
is mediated by inhibition of Hsp90
ER stress-mediated apoptosis induced by
celastrol
in cancer cells and important role of glycogen synthase kinase-3β in the signal network
Erratum for: Elucidation of the Intestinal Absorption Mechanism of
celastrol
Using the Caco-2 Cell Transwell Model.
Erratum to:
celastrol
suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor
Evaluation of anticancer activity of
celastrol
liposomes in prostate cancer cells
Evaluation of connectivity map-discovered
celastrol
as a radiosensitizing agent in a murine lung carcinoma model: Feasibility study of diffusion-weighted …
Evaluation of Neuroprotective Effect of
celastrol
in Optic Nerve Crush Model
Exosomal formulation enhances therapeutic response of
celastrol
against lung cancer
Folate receptor-mediated
celastrol
and irinotecan combination delivery using liposomes for effective chemotherapy
Formulation and evaluation of celastrol-loaded liposomes
FRI0367
celastrol
Inhibits Osteoclastogenesis and Bone Resorption in Rankl-Induced Raw264. 7 via Nf-κB and MAPK Pathways and Attenuates Bone Erosion in …
Friedelane‐type triterpene cyclase in
celastrol
biosynthesis from Tripterygium wilfordii and its application for triterpenes biosynthesis in yeast
Gambogic acid and
celastrol
are two powerful anti-inflammatory drugs in arthritis
Genetic transformation system for woody plant Tripterygium wilfordii and its application to product natural celastrol
Gold nanourchins and
celastrol
reorganize the nucleo-and cytoskeleton of glioblastoma cells
GW27-e0848 Effect of
celastrol
on Insulin Resistance and ROS/IKK Signaling Pathway in Vascular Endothelial Cells
Herbal Component
celastrol
is an Inhibitor of UDP-Glucuronosyltransferase (UGT) 1A7
Heterogeneity in the properties of NEFL mutants causing Charcot–Marie–Tooth disease results in differential effects on neurofilament assembly and susceptibility to intervention by the chaperone-inducer,
celastrol
High-throughput study of the effects of
celastrol
on activated fibroblast-like synoviocytes from patients with rheumatoid arthritis
HPLC-MS/MS Determination of Trace Amount of
celastrol
in Urine After Purification with Solid-Phase Extraction [J]
Hsp90 inhibitor
celastrol
reinstates growth plate angiogenesis in thiram-induced tibial dyschondroplasia
HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way
Identification of
celastrol
as a Novel YAP-TEAD Inhibitor for Cancer Therapy by High Throughput Screening with Ultrasensitive YAP/TAZ–TEAD Biosensors
Identification of Metabolites from Triptolide and
celastrol
in Rats
Improvement of mitochondrial function by
celastrol
in palmitate-treated C2C12 myotubes via activation of PI3K-Akt signaling pathway
Improving Dissolution Properties by Polymers and Surfactants: A Case Study of Celastrol
IN VITRO 3D PHENOTYPIC DRUG SCREEN IDENTIFIES
celastrol
AS AN EFFECTIVE IN VIVO INHIBITOR OF POLYCYSTIC KIDNEY DISEASE
In vitro and in vivo anti-tumor effects of a combination therapy of curcumin and
celastrol
to gastric cancer
In vitro immunomodulatory activity of
celastrol
against influenza A virus infection
In vitro inhibition of
celastrol
on spermatozoa fertilization ability of guinea pig
Induction of heat shock proteins in cerebral cortical cultures by celastrol
Induction of heat shock proteins in differentiated human and rodent neurons by celastrol
Induction of heat shock proteins in differentiated human neuronal cells following co-application of
celastrol
and arimoclomol
Inductive Effect of
celastrol
on Apoptosis of Human Multiple Myeloma Cell Line LP-1 [J]
Inflammation-Targeted Delivery of
celastrol
via Neutrophil Membrane-Coated Nanoparticles in the Management of Acute Pancreatitis
Influence of
celastrol
on toll-like receptor 4-mediated signaling pathway in the free fatty acids-induced HepG2 cells
Inhibiting Effect of
celastrol
on Immune Responses
Inhibiting inducible miR-223 further reduces viable cells in human cancer cell lines MCF-7 and PC3 treated by celastrol
Inhibition of anthrax lethal toxin-induced cytolysis of RAW264. 7 cells by celastrol
Inhibition of autophagy strengthens celastrol-induced apoptosis in human pancreatic cancer in vitro and in vivo models
Inhibition of C2C12 myotube atrophy by a novel HSP70 inducer, celastrol, via activation of Akt1 and ERK1/2 pathways
Inhibition of c-myc by the triterpenoid celastrol
Inhibition of IKKβ by
celastrol
and its analogues – an in silico and in vitro approach
Inhibition of inflammation with
celastrol
fails to improve muscle function in dysferlin-deficient A/J mice
Inhibition of NF-κB activation through targeting IκB kinase by celastrol, a quinone methide triterpenoid
Inhibition of proliferation of adult T-cell leukemia cells by celastrol
Inhibitory action of
celastrol
on hypoxia-mediated angiogenesis and metastasis via the HIF-1α pathway
Inhibitory effect of
celastrol
on adipogenic differentiation of human adipose-derived stem cells
Inhibitory effect of
celastrol
on cell viability of urinary bladder cancer cell line 5637 cells through JAK2/STAT3 signaling pathway
Inhibitory effects of
celastrol
on primary hepatocytes of HBV transgenic mice
Inhibitory effects of
celastrol
on rat liver cytochrome P450 1A2, 2C11, 2D6, 2E1 and 3A2 activity
Inhibitory mechanisms of
celastrol
on human liver cytochrome P450 1A2, 2C19, 2D6, 2E1 and 3A4
Integrated metabolomics and network toxicology to reveal molecular mechanism of
celastrol
induced cardiotoxicity
Investigation of the influence of glycyrrhizin on the pharmacokinetics of
celastrol
in rats using LC-MS and its potential mechanism
Lack of neuroprotective effect of
celastrol
under conditions of proteasome inhibition by lactacystin in in vitro and in vivo studies: implications for Parkinson’s …
LC–APCI–MS–MS for the Determination of
celastrol
in Human Whole Blood
Leptin sensitizer celastrol, glial calcineurin and hypothalamic glutathione peroxidase 7-novel entities in weight control and glucose homeostasis
Lipids:
celastrol
protects against fatty liver through SIRT1
Lipocalin 2 Does Not Play A Role in
Celastrol
-Mediated Reduction in Food Intake and Body Weight
LKB1 and YAP phosphorylation play important roles in
Celastrol
-induced β-catenin degradation in colorectal cancer
Loading of water-insoluble
celastrol
into niosome hydrogels for improved topical permeation and anti-psoriasis activity
Localization of heat shock proteins in cerebral cortical cultures following induction by celastrol
Mechanism of action of
celastrol
against rheumatoid arthritis: A network pharmacology analysis
Medicinal Compound
celastrol
As a Potential Clinical Anticancer Drug: Lessons Learned From Preclinical Studies
Metabolomics profiles delineate uridine deficiency contributes to mitochondria-mediated apoptosis induced by
celastrol
in human acute promyelocytic …
Metabolomics Reveals Cysteine Metabolism Plays a Role in
Celastrol
-Induced Mitochondrial Apoptosis of Acute Promyelocytic Leukemia Cells
Microarray-based gene expression profiling reveals the mediators and pathways involved in the anti-arthritic activity of Celastrus-derived Celastrol
miR-224 is critical for
celastrol
-induced inhibition of migration and invasion of hepatocellular carcinoma cells
miR-33a-5p enhances the sensitivity of lung adenocarcinoma cells to
celastrol
by regulating mTOR signaling
Mitochondrial alkaline pH-responsive drug release mediated by
celastrol
loaded glycolipid-like micelles for cancer therapy
Modulation of inflammatory signaling and cytokine release from microglia by
celastrol
incorporated into dendrimer nanocarriers
Modulation of lipid metabolism by
celastrol
Modulatory effect of
celastrol
on Th1/Th2 cytokines profile, TLR2 and CD3+ T-lymphocyte expression in a relapsing–remitting model of multiple sclerosis in rats
Molecular mechanism of
celastrol
in the treatment of systemic lupus erythematosus based on network pharmacology and molecular docking technology
Molecular mechanism of inhibition of the human protein complex Hsp90–Cdc37, a kinome chaperone–cochaperone, by triterpene
celastrol
Molecular modulators of
celastrol
as the keystones for its diverse pharmacological activities
Molecular Studies on Celastrol-induced Bcr-Abl Oncoprotein Degradation in Human Leukemia Cells
Molecular targets of
celastrol
derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer
Molecular targets of
celastrol
in cancer: Recent trends and advancements
Mutations Y493G and K546D in human HSP 90 disrupt binding of
celastrol
and reduce interaction with Cdc37
NADPH oxidase (NOX) isoforms are inhibited by
celastrol
with a dual mode of action
Nanoencapsulation of natural triterpenoid
celastrol
for prostate cancer treatment
Nascent RNA sequencing reveals a dynamic global transcriptional response at genes and enhancers to the natural medicinal compound
celastrol
Natural product
celastrol
destabilizes tubulin heterodimer and facilitates mitotic cell death triggered by microtubule-targeting anti-cancer drugs
Natural product
celastrol
suppressed macrophage M1 polarization against inflammation in diet-induced obese mice via regulating Nrf2/HO-1, MAP kinase and …
Natural products triptolide,
celastrol
, and withaferin A inhibit the chaperone activity of peroxiredoxin I
Natural Proteasome Inhibitor
celastrol
Suppresses Androgen-Independent Prostate Cancer
Natural proteasome inhibitor
celastrol
suppresses androgen-independent prostate cancer progression by modulating apoptotic proteins and NF-kappaB
New strategy of photodynamic treatment of TiO 2 nanofibers combined with
celastrol
for HepG2 proliferation in vitro
NF-kappa B modulation is involved in
celastrol
induced human multiple myeloma cell apoptosis
NF-kB Inhibition via
Celastrol
-Loaded Nanocarriers Induces Distinct Changes in Atheroma-Resident Immune Cell Composition in Male vs. Female ldlr-/-Mice
Non-triggered sequentially-released liposomes enhance anti-breast cancer efficacy of STS and celastrol-based microemulsion
Non-triggered sequential-release liposomes enhance anti-breast cancer efficacy of STS and celastrol-based microemulsion
Novel
celastrol
derivatives inhibit the growth of hepatocellular carcinoma patient-derived xenografts
Novel
celastrol
derivatives with improved selectivity and enhanced antitumour activity: Design, synthesis and biological evaluation
Novel low-toxic derivative of
celastrol
maintains protective effect against acute renal injury
Optimization and biological evaluation of
celastrol
derivatives as Hsp90–Cdc37 interaction disruptors with improved druglike properties
Optimization of Preparation and Preclinical Pharmacokinetics of
Celastrol
-Encapsulated Silk Fibroin Nanoparticles in the Rat
Optimized preparation of
celastrol
-loaded polymeric nanomicelles using rotatable central composite design and response surface methodology
Oral bioavailability and gender-related pharmacokinetics of
celastrol
following administration of pure
celastrol
and its related tablets in rats
Overcoming cisplatin resistance by
celastrol
in cancer cells.
Overexpression and RNAi-mediated downregulation of TwIDI regulates triptolide and
celastrol
accumulation in Tripterygium wilfordii
P52. The IKK inhibitors
celastrol
and parthenolide inhibit breast cancer cell proliferation and migration in vitro and osteolytic bone metastasis in vivo
Paraptosis accompanied by autophagy and apoptosis was induced by
celastrol
, a natural compound with influence on proteasome, ER stress and Hsp90
Paraptosis accompanied by autophagy and apoptosis was induced by
celastrol
, a natural compound with influence on proteasome, ER stress and Hsp90.
PEGylated lipid bilayer-supported mesoporous silica nanoparticle composite for synergistic co-delivery of axitinib and
celastrol
in multi-targeted cancer therapy
PEGylated polyaminoacid-capped mesoporous silica nanoparticles for mitochondria-targeted delivery of
celastrol
in solid tumors
Pharmacogenomic approach reveals a role for the xc− cystine/glutamate antiporter in growth and
celastrol
resistance of glioma cell lines
Pharmacological induction of Heat Shock Protein 70 by
celastrol
protects motoneurons from excitotoxicity in rat spinal cord in vitro
Plant-derived triterpene
celastrol
ameliorates oxygen glucose deprivation-induced disruption of endothelial barrier assembly via inducing tight junction proteins
Potent suppression of both spontaneous and carcinogen-induced colitis-associated colorectal cancer in mice by dietary
celastrol
supplementation
PRECLINICAL EVALUATION OF
celastrol
AS A PHARMACOLOGICAL DRUG CANDIDATE FOR INFARCT SIZE REDUCTION
Preclinical studies of
celastrol
and acetyl isogambogic acid in melanoma
Pre-conditioning of stem cell with
celastrol
to enhance their therapeutical potential
Prediction of Drug-Drug Interaction Due to the Inhibition of Specific Intestinal Drug-Metabolizing Enzymes by
Celastrol
Preliminary study on cardiotoxicity of
celastrol
to zebrafish embryo
Preliminary study on fabrication, characterization and synergistic anti-lung cancer effects of self-assembled micelles of covalently conjugated celastrol–polyethylene glycol–ginsenoside Rh2
Preparation, characterization and cytotoxic evaluation of inclusion complexes between
celastrol
with polyamine-modified β-cyclodextrins
Preparation, characterization, and assessment of the antiglioma effects of liposomal
celastrol
Preparative isolation and purification of
celastrol
from Celastrus orbiculatus Thunb. by a new counter-current chromatography method with an upright coil planet …
Preventive Effects of “Ovalbumin-Conjugated Celastrol-Loaded Nanomicelles” in a Mouse Model of Ovalbumin-Induced Allergic Airway Inflammation
Production of Tripterygium regelii differentiated biomass as a sustainable source of celastrol
Prooxidative Activity of
celastrol
Induces Apoptosis, DNA Damage, and Cell Cycle Arrest in Drug-Resistant Human Colon Cancer Cells
Protective effect of
celastrol
for burn-induced acute lung injury in rats
Protective effect of
celastrol
in rat cerebral ischemia model: down-regulating p-JNK, pc-Jun and NF-κB
Protective effect of
celastrol
on allergic rhinitis in rats
Protective effect of
celastrol
on myocardial ischemia–reperfusion injury
Protective effects of
celastrol
against γ irradiation‑induced oxidative stress in human umbilical vein endothelial cells
Protective effects of
celastrol
on diabetic liver injury via TLR4/MyD88/NF-κB signaling pathway in type 2 diabetic rats
Protective effects of
celastrol
on diethylnitrosamine-induced hepatocellular carcinoma in rats and its mechanisms
Protective Effects of
Celastrol
, the Triterpenoid Component of Celastrus Orbiculatus, on Dopaminergic Neuronal Cells in 1-methyl-4-phenyl-1, 2, 3, 6 …
Quantitative bioimage analytics enables measurement of targeted cellular stress response induced by
celastrol
-loaded nanoparticles
Quantitative proteomics reveals cellular targets of
celastrol
Quinone methide tripterine,
celastrol
, induces apoptosis in human myeloma cells via NF-κB pathway
Radiosensitization by
celastrol
is mediated by modification of antioxidant thiol molecules
Reduction of β-amyloid pathology by
celastrol
in a transgenic mouse model of Alzheimer’s disease
Regiochemistry discoveries in the use of isoxazole as a handle for the rapid construction of an all-carbon macrocyclic precursor in the synthetic studies of
celastrol
Regulation of Transforming Growth Factor‐β/Smad‐mediated Epithelial–Mesenchymal Transition by
celastrol
Provides Protection against Bleomycin‐induced …
Release of Ca2+ from the endoplasmic reticulum and its subsequent influx into mitochondria trigger celastrol-induced paraptosis in cancer cells
Remarkable stereospecific conjugate additions to the Hsp90 inhibitor
celastrol
Repression of acetaminophen-induced hepatotoxicity by a combination of
celastrol
and brilliant blue G
Research progress in pharmacologic molecular targets of
celastrol
Research Progress on the Anti-tumor Effect of
Celastrol
Role of
celastrol
in Chemosensitization of Cancer
Role of
celastrol
in Regulating Proliferation and Apoptosis of Lung Cancer Cell
Role of the eIF4E binding protein 4E‐BP1 in regulation of the sensitivity of human pancreatic cancer cells to TRAIL and
celastrol
‐induced apoptosis
SAR study of
celastrol
analogs targeting Nur77-mediated inflammatory pathway
Self-assembled phospholipid-based phytosomal nanocarriers as promising platforms for improving oral bioavailability of the anticancer celastrol
Separation, identification and quantitative determination of
celastrol
from the root bark of Celastrus hookeri
Simultaneous determination of triptolide, tripterifordin,
celastrol
and nine sesquiterpene alkaloids in Tripterygium preparations using high-performance liquid …
Simultaneous NF‐κB inhibition and E‐cadherin upregulation mediate mutually synergistic anticancer activity of
celastrol
and SAHA in vitro and in vivo
Simultaneous targeting therapy for lung metastasis and breast tumor by blocking the NF-κB signaling pathway using
celastrol
-loaded micelles
Small Molecule Induction of the Heat Shock Response: Cytoprotective Effects and Potential Clinical Applications of
Celastrol
Solid self-microemulsifying dispersible tablets of celastrol: Formulation development, charaterization and bioavailability evaluation
Strong inhibition of
celastrol
towards UDP-glucuronosyl transferase (UGT) 1A6 and 2B7 indicating potential risk of UGT-based herb-drug interaction
Structural basis of potent antiperoxidation activity of the triterpene
celastrol
in mitochondria: effect of negative membrane surface charge on lipid peroxidation
Structure of Pristimerin and
Celastrol
Studies toward the synthesis of
celastrol
and the late-stage hydroxylation of arenes mediated by 4, 5-dichlorophthaloyl peroxide
Study of
celastrol
on akt signaling pathway and its roles in the apoptosis of K562 cells
Study on Extraction and Purification of
celastrol
from C. Anticulatus Thunb
Study on Preparation of
celastrol
Ethosome and Its Skin Penetration Properties in Vitro
Study on the Effects and Mechanism of
celastrol
on Proliferation and Apoptosis of Human Hepatoma HepG2 Cells in vitro
Sugar-decorated mesoporous silica nanoparticles as delivery vehicles for the poorly soluble drug
celastrol
enables targeted induction of apoptosis in cancer cells
SUN-096 Hypothalamic ATP Has a Crucial Role in the Pathogenesis of Leptin Resistance: A Potential Mechanism for the Amelioration of Leptin Resistance by
celastrol
and Withaferin A
Suppression of autoimmune arthritis by Celastrus-derived
celastrol
through modulation of pro-inflammatory chemokines
Suppression of inflammatory responses by
celastrol
, a quinone methide triterpenoid isolated from Celastrus regelii
Synergism between NF-kappa B inhibitor,
celastrol
, and XIAP inhibitor, embelin, in an acute myeloid leukemia cell line, HL-60
Synergistic anti-cancer activity by the combination of TRAIL/APO-2L and
celastrol
Synergistic anticancer effects of triptolide and
celastrol
, two main compounds from thunder god vine
Synergistic combination chemotherapy using carrier-free
celastrol
and doxorubicin nanocrystals for overcoming drug resistance
Synthesis and anti-cancer evaluation of novel
celastrol
analogues
Synthesis and anti-tumor activity study of water-soluble PEG-
celastrol
coupling derivatives as self-assembled nanoparticles
Synthesis and biological evaluation of a series of novel
celastrol
derivatives with amino acid chain
Synthesis and biological evaluation of
celastrol
derivatives as anti-ovarian cancer stem cell agents
Synthesis and characterisation of
celastrol
derivatives as potential anticancer agents
Synthesis and preliminary evaluation of neuroprotection of
celastrol
analogues in PC12 cells
Synthesis of 3-and 29-substituted
celastrol
derivatives and structure-activity relationship studies of their cytotoxic activities
Synthetic studies on a novel celastrol-fluo-rescent probe for in vivo imaging and novel amination methodologies
Systematic identification of Celastrol-binding proteins reveals that Shoc2 is inhibited by
Celastrol
Targeted delivery of
celastrol
to mesangial cells is effective against mesangioproliferative glomerulonephritis
Targeting b1 integrin,
celastrol
as a potent anti-metastatic agent, inhibits cell-ECM adhesion, partially via the p38 MAPK pathway
Targeting Mast Cells and Basophils with Anti-FcεRIα Fab-Conjugated
Celastrol
-Loaded Micelles Suppresses Allergic Inflammation
Targeting the osteoarthritis via the combination of TCM
Celastrol
, novel modified mirna and rapalogue
TAZ promotes cell growth and inhibits Celastrol-induced cell apoptosis
The Anti-cancer effects of
celastrol
on K562 cell line
The cellular labeling and pH-sensitive responsive-drug release of
celastrol
in cancer cells based on Cys-CdTe QDs
The effect of
celastrol
on learing and memory in mice after artiacl hepatectomy
The effect of
celastrol
on learning and memory in diabetic rats after sevoflurane inhalation
The effect of
celastrol
on the expressions of RANKL, OPG, IL-6, TNF-α and IL-8 in human rheumatoid synoviocyte MH7A [J]
The effect of
celastrol
on the ocular hypertension-induced degeneration of retinal ganglion cells
The effect of celastrol, a triterpene with antitumorigenic activity, on conformational and functional aspects of the human 90 kDa heat shock protein Hsp90α, a …
The experimental studies of
celastrol
on the reversal of multidrug resistance in K562/A02 cell line
The impact of
celastrol
on cognitive function and expressions of Aβ40 and Aβ42 in hippocampus in APPswe/PS1dE9 double transgenic mouse after partial …
The inhibitive effects of
celastrol
on LDL oxidation and HAEC cell oxidative damage
The inhibitory effects of
celastrol
on proliferation, invasion and migration of human pancreatic cancer cell line PANC-1
The leptin sensitizer
celastrol
reduces age‐associated obesity and modulates behavioral rhythms
The MVA pathway genes expressions and accumulation of
celastrol
in Tripterygium wilfordii suspension cells in response to methyl jasmonate treatment
The natural anti-tumor compound
celastrol
targets a Myb-C/EBPβ-p300 transcriptional module implicated in myeloid gene expression
The natural compound
celastrol
inhibits necroptosis and alleviates ulcerative colitis in mice
THE NATURAL PROTEASOME INHIBITOR
celastrol
CAN ACCELERATE DNA REPAIR IN HUMAN LYMPHOCYTES
The NF-kappa B inhibitor,
celastrol
, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma
The NF-κB inhibitor
celastrol
attenuates acute hepatic dysfunction induced by cecal ligation and puncture in rats
The plant triterpenoid
celastrol
blocks PINK1-dependent mitophagy by disrupting PINK1’s association with the mitochondrial protein TOM20
The research of
celastrol
on its effect of inducing gastric cancer cell line MGC803 apoptosis [J]
The ROS derived mitochondrial respirstion not from NADPH oxidase plays key role in
celastrol
against angiotensin II-mediated HepG2 cell proliferation
The suppressive effect of
celastrol
against Multiple Myeloma Cell Line RPMI8226 in vitro [J]
The therapeutic potential of pharmacological chaperones and proteosomal inhibitors,
celastrol
and MG132 in the treatment of sialidosis
The Transannular bis-Michael Reaction in the Synthetic Studies of
celastrol
and the Development of Novel Palladium-Catalyzed Reactions
The triterpene
celastrol
as a very potent inhibitor of lipid peroxidation in mitochondria
The use of
celastrol
in the fight against obesity
Therapeutic Effects and Related Molecular Mechanisms of Celastrol, a Triterpenoid Natural Compound and Novel HSP90 Inhibitor Extracted from Plants of the …
Therapeutic effects of
celastrol
on DEN induced liver fibrosis rats and its mechanisms
Total synthesis of celastrol, development of a platform to access celastroid natural products
Toxic effects of
celastrol
on embryonic development of zebrafish (Danio rerio)
Transdermal delivery system of nanostructured lipid carriers loaded with
celastrol
and Indomethacin: optimization, characterization and efficacy evaluation for …
Transferrin-functionalised microemulsion co-delivery of β-elemene and
celastrol
for enhanced anti-lung cancer treatment and reduced systemic toxicity
Treatment of obesity with celastrol
Treatment with
celastrol
protects against obesity through suppression of galanin-induced fat intake and activation of pgc-1α/glut4 axis-mediated glucose consumption
Triptolide and
celastrol
loaded silk fibroin nanoparticles show synergistic effect against human pancreatic cancer cells
Ultrasound-assisted ionic liquid dispersive liquid–liquid microextraction coupled with high performance liquid chromatography for sensitive determination of trace
celastrol
in urine
UPLC-Q-TOF-MS-based metabolomics study of
celastrol
Upregulating Noxa by ER stress,
celastrol
exerts synergistic anti-cancer activity in combination with ABT-737 in human hepatocellular carcinoma cells
Up-regulation of death receptor 4 and 5 by
celastrol
enhances the anti-cancer activity of TRAIL/Apo-2L
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