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Celastrol

Celastrol (God Vine)

  1. 532 Priming of Stem Cells With celastrol to Enhance Survival for Cell Therapy
  2. A lipidomics investigation into the intervention of celastrol in experimental colitis
  3. A mechanistic overview of triptolide and celastrol, natural products from Tripterygium wilfordii Hook F
  4. A new mechanism of inhibition of IL-1β secretion by celastrol through the NLRP3 inflammasome pathway
  5. A novel nucleolin aptamer-celastrol conjugate (NACC) with super antitumor activity on advanced pancreatic cancer
  6. AB0096 Efficacy and safety of oral administration of pure celastrol in aia rats
  7. Abstract LB-266: Suppression of colitis-associated colon carcinogenesis by the natural triterpenoid celastrol
  8. Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule
  9. Advances in structural modifications of celastrol.
  10. AFM studied the effect of celastrol on β1 integrin‐mediated HUVEC adhesion and migration
  11. AFM Study of the Celastrol-induced Inhibition on Vein Endothelial Cells [J]
  12. AlCl3· 6H2O-Catalyzed Friedel-Crafts Alkylation of Indoles by the para-Quinone Methide Moiety of Celastrol
  13. Analysis of celastrol in whole blood by high-performance liquid chromatography coupled with mass spectrometry [J]
  14. Antiangiogenic effect of celastrol on the growth of human glioma: anin vitroandin vivostudy
  15. Antibacterial activity of celastrol against Bacillus subtilis
  16. Anti-biofilm and anti-virulence efficacy of celastrol against Stenotrophomonas maltophilia
  17. Anticancer activity of celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers
  18. Anticancer effect of celastrol on human triple negative breast cancer: possible involvement of oxidative stress, mitochondrial dysfunction, apoptosis and PI3K/Akt …
  19. Antifungal properties of pristimerin and celastrol isolated from Celastrus hypoleucus
  20. Anti-invasive effects of celastrol in hypoxia-induced fibroblast-like synoviocyte through suppressing of HIF-1α/CXCR4 signaling pathway
  21. Anti-metastasis of celastrol on esophageal cancer cells and its mechanism
  22. Antioxidant effects of celastrol against hydrogen peroxide-induced oxidative stress in the cell model of amyotrophic lateral sclerosis
  23. Anti-staphylococcal activity of celastrol
  24. Antitumor activity of celastrol by inhibition of proliferation, invasion, and migration in cholangiocarcinoma via PTEN/PI3K/Akt pathway
  25. Antitumor activity of celastrol nanoparticles in a xenograft retinoblastoma tumor model
  26. Antitumor effects of celastrol and semi-synthetic derivatives
  27. Apoptosis induced by celastrol on multiple cell lines and the effect on cell cycle [J]
  28. Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol
  29. ATF2 contributes to cisplatin resistance in non‐small cell lung cancer and celastrol induces cisplatin resensitization through inhibition of JNK/ATF2 pathway
  30. Attenuation of muscle atrophy by triterpentene celastrol
  31. Autophagic degradation of epidermal growth factor receptor in gefitinib-resistant lung cancer by celastrol
  32. Autophagy flux inhibition mediated by celastrol sensitized lung cancer cells to TRAIL‑induced apoptosis via regulation of mitochondrial transmembrane …
  33. Autophagy induction by celastrol augments protection against bleomycin-induced experimental pulmonary fibrosis in rats: Role of adaptor protein p62/SQSTM1
  34. Axl is a novel target of celastrol that inhibits cell proliferation and migration, and increases the cytotoxicity of gefitinib in EGFR mutant non‑small cell lung cancer cells
  35. Beta-catenin mediates the apoptosis induction effect of celastrol in HT29 cells
  36. Biological activity of the triterpene celastrol, analysis from the viewpoint of the apoptosis induction
  37. C57 CELLULAR/MOLECULAR MECHANISMS AND TRANSLATIONAL ASPECTS OF RESPIRATORY INFECTIONS: celastrol Promotes Granulocyte Differentiation …
  38. Ca2+ signalling plays a role in celastrol‐mediated suppression of synovial fibroblasts of rheumatoid arthritis patients and experimental arthritis in rats
  39. Cancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer
  40. Cascade regulation of PPARγ2 and C/EBPα signaling pathways by celastrol impairs adipocyte differentiation and stimulates lipolysis in 3T3-L1 adipocytes
  41. Celastrol
  42. celastrol & Triptolide from Tripterygium Wilfordii Powerful Anti-Cancer Treatments?
  43. celastrol acts as a potent antimetastatic agent targeting β1 integrin and inhibiting cell-extracellular matrix adhesion, in part via the p38 mitogen-activated protein …
  44. celastrol aggravates LPS-induced inflammation and injuries of liver and kidney in mice
  45. celastrol alleviates airway hyperresponsiveness and inhibits Th17 responses in obese asthmatic mice
  46. celastrol Alleviates Airway Hyperresponsiveness by Downregulating Th17 in Obese Asthmatic Mice
  47. celastrol alleviates angiotensin II‑mediated vascular smooth muscle cell senescence via induction of autophagy
  48. celastrol Alleviates Aortic Valve Calcification Via Inhibition of NADPH Oxidase 2 in Valvular Interstitial Cells
  49. celastrol alleviates arthritis by modulating the inflammatory activities of neutrophils
  50. celastrol Alleviates Chronic Obstructive Pulmonary Disease by Inhibiting Cellular Inflammation Induced by Cigarette Smoke via the Ednrb/Kng1 Signaling Pathway
  51. celastrol alleviates renal fibrosis by upregulating cannabinoid receptor 2 expression
  52. celastrol ameliorates acetaminophen-induced oxidative stress and cytotoxicity in HepG2 cells
  53. celastrol ameliorates Aspergillus fumigatus keratitis via inhibiting LOX-1
  54. celastrol ameliorates Cd‐induced neuronal apoptosis by targeting NOX2‐derived ROS‐dependent PP5‐JNK signaling pathway
  55. celastrol ameliorates cisplatin nephrotoxicity by inhibiting NF-κB and improving mitochondrial function
  56. celastrol ameliorates cytokine toxicity and pro-inflammatory immune responses by suppressing NF-κB activation in RINm5F beta cells
  57. celastrol ameliorates EAE induction by suppressing pathogenic T cell responses in the peripheral and central nervous systems
  58. celastrol ameliorates experimental colitis in IL-10 deficient mice via the up-regulation of autophagy
  59. celastrol ameliorates HIV-1 Tat-induced inflammatory responses via NF-kappaB and AP-1 inhibition and heme oxygenase-1 induction in astrocytes
  60. celastrol Ameliorates Inflammation in Human Retinal Pigment Epithelial Cells by Suppressing NF-κB Signaling
  61. celastrol ameliorates inflammation through inhibition of NLRP3 inflammasome activation
  62. celastrol ameliorates inflammatory pain and modulates HMGB1/NF-κB signaling pathway in dorsal root ganglion
  63. celastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1
  64. celastrol ameliorates murine colitis via modulating oxidative stress, inflammatory cytokines and intestinal homeostasis
  65. celastrol ameliorates ulcerative colitis-related colorectal cancer in mice via suppressing inflammatory responses and epithelial-mesenchymal transition
  66. celastrol analogues as inducers of the heat shock response. Design and synthesis of affinity probes for the identification of protein targets
  67. celastrol and an EGCG pro-drug exhibit potent chemosensitizing activity in human leukemia cells
  68. celastrol and attenuation of tumor growth in systemic malignancies: a clinical perspective
  69. celastrol and its role in controlling chronic diseases
  70. celastrol and terpenes as anti-infective agents
  71. celastrol antagonizes high glucose-evoked podocyte injury, inflammation and insulin resistance by restoring the HO-1-mediated autophagy pathway
  72. celastrol as a Novel Cardioprotective Drug
  73. celastrol as a pentacyclic triterpenoid with chemopreventive properties
  74. celastrol as a tool for the study of the biological events of metabolic diseases
  75. celastrol attenuates adipokine resistin‐associated matrix interaction and migration of vascular smooth muscle cells
  76. celastrol attenuates angiotensin II mediated human umbilical vein endothelial cells damage through activation of Nrf2/ERK1/2/Nox2 signal pathway
  77. celastrol attenuates atherosclerosis in Apolipoprotein E (apoE) knockout mice fed an atherogenic diet
  78. celastrol attenuates bone erosion in collagen-Induced arthritis mice and inhibits osteoclast differentiation and function in RANKL-induced RAW264. 7
  79. celastrol Attenuates Cadmium‐Induced Neuronal Apoptosis via Inhibiting Ca2+‐CaMKII‐Dependent Akt/mTOR Pathway
  80. celastrol attenuates fMLP-induced superoxide anion generation, myeloperoxidase production, and elastase release by human neutrophils
  81. celastrol attenuates hypertension-induced inflammation and oxidative stress in vascular smooth muscle cells via induction of heme oxygenase-1
  82. celastrol attenuates impairments associated with lipopolysaccharide-induced acute respiratory distress syndrome (ARDS) in rats
  83. celastrol attenuates incision-induced inflammation and pain associated with inhibition of the NF-κB signalling pathway via SARM
  84. celastrol attenuates inflammatory and neuropathic pain mediated by cannabinoid receptor type 2
  85. celastrol Attenuates Intrahepatic Cholestasis of Pregnancy by Inhibiting Matrix Metalloproteinases-2 and 9
  86. celastrol attenuates mitochondrial dysfunction and inflammation in palmitate-mediated insulin resistance in C3A hepatocytes
  87. celastrol attenuates multiple sclerosis and optic neuritis in an experimental autoimmune encephalomyelitis model
  88. celastrol attenuates oxidative stress in the skeletal muscle of diabetic rats by regulating the AMPK-PGC1α-SIRT3 signaling pathway
  89. celastrol attenuates ox-LDL-induced mesangial cell proliferation via suppressing NLRP3 inflammasome activation
  90. celastrol attenuates pain and cartilage damage via SDF‐1/CXCR 4 signalling pathway in osteoarthritis rats
  91. celastrol attenuates renal injury in diabetic rats via MAPK/NF‐κB pathway
  92. celastrol attenuates symptoms of preeclampsia in rats by inhibiting matrix metalloproteinase-9
  93. celastrol attenuates the invasion and migration and augments the anticancer effects of bortezomib in a xenograft mouse model of multiple myeloma
  94. celastrol attenuates ventilator induced lung injury in mouse through inhibition of MAPK pathway
  95. celastrol binds to ERK and inhibits FcεRI signaling to exert an anti-allergic effect
  96. celastrol Binds to HSP90 Trigger Functional Protein Interaction Network Against Pancreatic Cancer
  97. celastrol binds to its target protein via specific noncovalent interactions and reversible covalent bonds
  98. celastrol blocks binding of lipopolysaccharides to a Toll-like receptor4/myeloid differentiation factor2 complex in a thiol-dependent manner
  99. celastrol blocks interleukin-6 gene expression via downregulation of NF-κB in prostate carcinoma cells
  100. celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis
  101. celastrol can inhibit proteasome activity and upregulate the expression of heat shock protein genes, hsp30 and hsp70, in Xenopus laevis A6 cells
  102. celastrol causes apoptosis and cell cycle arrest in rat glioma cells
  103. celastrol could protect the INS-1from functional impairment
  104. celastrol Decreases Endoplasmic Reticulum (ER) Stress and Clinical Progression in the Cx3cr1-/-/Ccl2-/-Murine Model of Age-Related Macular Degeneration
  105. celastrol decreases specificity proteins (Sp) and fibroblast growth factor receptor-3 (FGFR3) in bladder cancer cells
  106. celastrol delays hepatic steatosis and carcinogenesis in a rapid AKT/c-Met-transfected hepatocellular carcinoma model via suppressing fatty acid synthase …
  107. celastrol downregulates E2F1 to induce growth inhibitory effects in hepatocellular carcinoma HepG2 cells
  108. celastrol down-regulates expression of P-Akt and cyclin D1 in HL-60 cells and induces apoptosis
  109. celastrol down-regulates expressions of MIF and MMP-9 in the aorta of ApoE gene knockout mice
  110. celastrol down-regulates expressions of MIF and MMP-9 in the aorta of ApoE gene knockout mice [J]
  111. celastrol enhanced the anticancer effect of lapatinib in human hepatocellular carcinoma cells in vitro
  112. celastrol enhances AAV1-mediated gene expression in mice adipose tissues
  113. celastrol enhances Atoh1 expression in inner ear stem cells and promotes their differentiation into functional auditory neuronal-like cells
  114. celastrol enhances cell viability and inhibits amyloid-β production induced by lipopolysaccharide in vitro
  115. celastrol enhances Nrf2 mediated antioxidant enzymes and exhibits anti-fibrotic effect through regulation of collagen production against bleomycin-induced …
  116. celastrol Enhances the Anti-Liver Cancer Activity of Sorafenib
  117. celastrol enhances TRAIL-induced apoptosis in human glioblastoma via the death receptor pathway
  118. celastrol exerts anti‐inflammatory effect in liver fibrosis via activation of AMPK‐SIRT3 signalling
  119. celastrol exerts synergistic effects with PHA-665752 and inhibits tumor growth of c-Met-deficient hepatocellular carcinoma in vivo
  120. celastrol from ‘Thunder God Vine’protects SH-SY5Y cells through the preservation of mitochondrial function and inhibition of p38 MAPK in a rotenone model of …
  121. celastrol identified as a leptin sensitizer and potential novel treatment for obesity
  122. celastrol improves self-renewal and differentiation of human tendon-derived stem cells by suppressing Smad7 through hypoxia
  123. celastrol improves the therapeutic efficacy of EGFR-TKIs for non-small-cell lung cancer by overcoming EGFR T790M drug resistance
  124. celastrol in the inhibition of neovascularization
  125. celastrol increases glucocerebrosidase activity in Gaucher disease by modulating molecular chaperones
  126. celastrol increases osteosarcoma cell lysis by γδ T cells through up-regulation of death receptors
  127. celastrol induce apoptosis of human multiple myeloma cells involving inhibition of proteasome activity
  128. celastrol induced cell cycle arrest in Her2/neu-overexpressing MDA-MB-453 cancer cells and its mechanisms
  129. celastrol induced DNA damage, cell cycle arrest, and apoptosis in human rheumatoid fibroblast-like synovial cells
  130. celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells: an in vitro and in vivo study
  131. celastrol induces apoptosis in gefitinib-resistant non-small cell lung cancer cells via caspases-dependent pathways and Hsp90 client protein degradation
  132. celastrol induces apoptosis in hepatocellular carcinoma cells via targeting ER-stress/UPR
  133. celastrol induces apoptosis in human colon cancer SW620 cells through species reactive oxygen
  134. celastrol induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria-and Fas/FasL-mediated pathways
  135. celastrol induces apoptosis of gastric cancer cells by miR-146a inhibition of NF-κB activity
  136. celastrol induces apoptosis of gastric cancer cells by miR-21 inhibiting PI3K/Akt-NF-κB signaling pathway
  137. celastrol induces apoptosis of human osteosarcoma cells via the mitochondrial apoptotic pathway
  138. celastrol induces apoptosis through modulation of estrogen receptor in human breast cancer cells
  139. celastrol induces autophagy by targeting AR/miR-101 in prostate cancer cells
  140. celastrol induces caspase-dependent apoptosis through ROS/JNK path-way in Saos-2 cells
  141. celastrol induces cell apoptosis and inhibits the expression of the AML1-ETO/C-KIT oncoprotein in t (8; 21) leukemia
  142. celastrol induces cell cycle arrest by MicroRNA-21-mTOR-mediated inhibition p27 protein degradation in gastric cancer
  143. celastrol induces expression of heme oxygenase-1 through ROS/Nrf2/ARE signaling in the HaCaT cells
  144. celastrol induces mitochondria-mediated apoptosis in hepatocellular carcinoma Bel-7402 cells
  145. celastrol Induces Necroptosis and Ameliorates Inflammation via Targeting Biglycan in Human Gastric Carcinoma
  146. celastrol induces paraptosis-like cell death via mitochondrial Ca2+ overload in breast cancer cells
  147. celastrol induces proteasomal degradation of FANCD 2 to sensitize lung cancer cells to DNA crosslinking agents
  148. celastrol induces the apoptosis of breast cancer cells and inhibits their invasion via downregulation of MMP-9
  149. celastrol induces ubiquitin-dependent degradation of mTOr in breast cancer cells
  150. celastrol induces unfolded protein response-dependent cell death in head and neck cancer
  151. celastrol induces vincristine multidrug resistance oral cancer cell apoptosis by targeting JNK1/2 signaling pathway
  152. celastrol inhibits aminoglycoside-induced ototoxicity via heat shock protein 32
  153. celastrol Inhibits Breast Cancer Cell Invasion via Suppression of NF-ĸB-mediated Matrix Metalloproteinase-9 Expression
  154. celastrol inhibits breast cancer cell invasion via suppression of NF-ĸB-mediated matrix metalloproteinase-9 expression.
  155. celastrol inhibits cancer metastasis by suppressing M2-like polarization of macrophages
  156. celastrol inhibits chondrosarcoma proliferation, migration and invasion through suppression CIP2A/c-MYC signaling pathway
  157. celastrol inhibits colon cancer cell proliferation by downregulating miR-21 and PI3K/AKT/GSK-3β pathway
  158. celastrol inhibits colorectal cancer cell proliferation and migration through suppression of MMP3 and MMP7 by the PI3K/AKT signaling pathway
  159. celastrol inhibits colorectal cancer through TgF-β1/smad signaling
  160. celastrol inhibits dengue virus replication via up-regulating type I interferon and downstream interferon-stimulated responses
  161. celastrol Inhibits Dopaminergic Neuronal Death of Parkinson’s Disease through Activating Mitophagy
  162. celastrol inhibits gastric cancer growth by induction of apoptosis and autophagy
  163. celastrol inhibits glucocorticoid‑induced osteoporosis in rat via the PI3K/AKT and Wnt signaling pathways
  164. celastrol inhibits growth and increases apoptosis of human lung cancer A549 cells
  165. celastrol inhibits growth and induces apoptotic cell death in melanoma cells via the activation ROS-dependent mitochondrial pathway and the suppression of PI3K …
  166. celastrol inhibits growth and metastasis of human gastric cancer cell MKN45 by down‐regulating microRNA‐21
  167. celastrol inhibits hepatitis C virus replication by upregulating heme oxygenase-1 via the JNK MAPK/Nrf2 pathway in human hepatoma cells
  168. celastrol inhibits high fat diet-induced obesity and intestinal tumorigenesis in APCMin/+ mice by modulating gut microbes and inflammation
  169. celastrol inhibits Hsp90 and triggers ER stress-induced cell death in non-small cell lung cancer cells
  170. celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23
  171. celastrol inhibits human glioma xenograft
  172. celastrol Inhibits Hypoxia-Inducible Factor-1α Activation in Hepatocellular Carcinoma Cells
  173. celastrol inhibits IL-1β-induced inflammation in orbital fibroblasts through the suppression of NF-κB activity
  174. celastrol inhibits inflammatory stimuli-induced neutrophil extracellular trap formation
  175. celastrol inhibits interleukin-17A-stimulated rheumatoid fibroblast-like synoviocyte migration and invasion through suppression of NF-κB-mediated matrix …
  176. celastrol inhibits lipopolysaccharide-induced angiogenesis by suppressing TLR4-triggered nuclear factor-kappa B activation
  177. celastrol inhibits lipopolysaccharide-stimulated rheumatoid fibroblast-like synoviocyte invasion through suppression of TLR4/NF-κB-mediated matrix …
  178. celastrol inhibits lung infiltration in differential syndrome animal models by reducing TNF-α and ICAM-1 levels while preserving differentiation in ATRA …
  179. celastrol inhibits microglial pyroptosis and attenuates inflammatory reaction in acute spinal cord injury rats
  180. celastrol inhibits migration and invasion through blocking the NF‑κB pathway in ovarian cancer cells
  181. celastrol inhibits migration, proliferation and transforming growth factor-β2-induced epithelial-mesenchymal transition in lens epithelial cells
  182. celastrol inhibits Plasmodium falciparum enoyl-acyl carrier protein reductase
  183. celastrol inhibits polyglutamine aggregation and toxicity though induction of the heat shock response
  184. celastrol inhibits production of nitric oxide and proinflammatory cytokines through MAPK signal transduction and NF-κB in LPS-stimulated BV-2 microglial cells
  185. celastrol inhibits pro-inflammatory cytokine secretion in Crohn’s disease biopsies
  186. celastrol inhibits proliferation and induces chemosensitization through down‐regulation of NF‐κB and STAT3 regulated gene products in multiple myeloma cells
  187. celastrol inhibits prostaglandin E2-induced proliferation and osteogenic differentiation of fibroblasts isolated from ankylosing spondylitis hip tissues in vitro
  188. celastrol inhibits Tat-mediated human immunodeficiency virus (HIV) transcription and replication
  189. celastrol inhibits TGF-β1-induced epithelial–mesenchymal transition by inhibiting Snail and regulating E-cadherin expression
  190. celastrol inhibits the growth of estrogen positive human breast cancer cells through modulation of estrogen receptor α
  191. celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression
  192. celastrol inhibits the growth of ovarian Cancer cells in vitro and in vivo
  193. celastrol inhibits the HIF-1α pathway by inhibition of mTOR/p70S6K/eIF4E and ERK1/2 phosphorylation in human hepatoma cells
  194. celastrol inhibits the secretion of interleukin-17 in peripheral blood mononuclear cells in patients with sympathetic ophthalmia
  195. celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways
  196. celastrol inhibits vasculogenesis by suppressing the VEGF-induced functional activity of bone marrow-derived endothelial progenitor cells
  197. celastrol is a novel selective agonist of cannabinoid receptor 2 with anti-inflammatory and anti-fibrotic activity in a mouse model of systemic sclerosis
  198. celastrol isolated from Tripterygium regelii induces apoptosis through both caspase-dependent and-independent pathways in human breast cancer cells
  199. celastrol Limits Autoimmune Arthritis by Reducing Th17 and Promoting Treg Cells in Inflamed Joints
  200. celastrol may have an anti-atherosclerosis effect in a rabbit experimental carotid atherosclerosis model
  201. celastrol Mediated Hsp90 Protein Inhibition in Cancer
  202. celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells
  203. celastrol mediates Th17 and Treg cell generation via metabolic signaling
  204. celastrol modulated Taz and induced cell apoptosis in vitro
  205. celastrol modulates inflammation through inhibition of the catalytic activity of mediators of arachidonic acid pathway: Secretory phospholipase A2 group IIA, 5 …
  206. celastrol Modulates inflammatory Responses in Retinal Pigment Epithelial Cells (RPE)
  207. celastrol Modulates Lipid Synthesis via PI3K/Akt/mTOR Signaling Axis to finalize Cell Death Response in Prostate Cancer Cells
  208. celastrol nanomicelles attenuate cytokine secretion in macrophages and inhibit macrophage-induced corneal neovascularization in rats
  209. celastrol nanoparticles inhibit corneal neovascularization induced by suturing in rats
  210. celastrol negatively regulates cell invasion and migration ability of human osteosarcoma via downregulation of the PI3K/Akt/NF-κB signaling pathway in vitro
  211. celastrol overcomes HSP72 gene silencing-mediated muscle atrophy and induces myofiber preservation
  212. celastrol potentiates radiotherapy by impairment of DNA damage processing in human prostate cancer
  213. celastrol preserves bone structure and mechanics in arthritic rats
  214. celastrol pretreatment as a therapeutic option against cisplatin-induced nephrotoxicity
  215. celastrol pretreatment attenuates rat myocardial ischemia/reperfusion injury by inhibiting high mobility group box 1 protein expression via the PI3K/Akt pathway
  216. celastrol PREVENTS ADVERSE CARDIAC REMODELING OF THE ISCHEMIC MYOCARDIUM
  217. celastrol prevents atherosclerosis via inhibiting LOX-1 and oxidative stress
  218. celastrol prevents cadmium‐induced neuronal cell death by blocking reactive oxygen species‐mediated mammalian target of rapamycin pathway
  219. celastrol prevents cadmium‐induced neuronal cell death via targeting JNK and PTEN‐Akt/mTOR network
  220. celastrol prevents circulatory failure via induction of heme oxygenase-1 and heat shock protein 70 in endotoxemic rats
  221. celastrol Promotes Granulocyte Differentiation To Protect Against Bacteria
  222. celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus
  223. celastrol protects against antimycin A-induced insulin resistance in human skeletal muscle cells
  224. celastrol PROTECTS AGAINST ISCHEMIA/REPERFUSION-INDUCED CARDIAC CELL DEATH
  225. celastrol protects against MPTP‐and 3‐nitropropionic acid‐induced neurotoxicity
  226. celastrol protects against obesity and metabolic dysfunction through activation of a HSF1-PGC1α transcriptional axis
  227. celastrol protects from cholestatic liver injury through modulation of SIRT1-FXR signaling
  228. celastrol protects human neuroblastoma SH-SY5Y cells from rotenone-induced injury through induction of autophagy
  229. celastrol protects human retinal pigment epithelial cells against hydrogen peroxide mediated oxidative stress, autophagy, and apoptosis through sirtuin 3 signal …
  230. celastrol protects kidney against ischemia–reperfusion-induced injury in rats
  231. celastrol protects mouse retinas from bright light-induced degeneration through inhibition of oxidative stress and inflammation
  232. celastrol Protects Retinal Ganglion Cells from Optic Nerve Crush but not from Glaucomatous Damage
  233. celastrol Protects RPE Cells from Oxidative Stress-Induced Cell Death via Activation of Nrf2 Signaling Pathway
  234. celastrol protects TGF-β1-induced endothelial-mesenchymal transition
  235. celastrol Reduces Airway Hypersensitivity and Lung Tissue Remodeling Via Regulating the Production of MMP-2/9 in Mouse Allergic Asthma Model.
  236. celastrol reduces IL-1β induced matrix catabolism, oxidative stress and inflammation in human nucleus pulposus cells and attenuates rat intervertebral disc …
  237. celastrol Reduces Obesity in MC4R Deficiency and Stimulates Sympathetic Nerve Activity Affecting Metabolic and Cardiovascular Functions
  238. celastrol Regulates Innate Immunity Response Via Nf-B And Hsp70 In Human Retinal Pigment Epithelial Cells
  239. celastrol regulates innate immunity response via NF‐kB and HSP70 in ARPE‐19 cells
  240. celastrol regulates innate immunity response via NF-κB and Hsp70 in human retinal pigment epithelial cells
  241. celastrol regulates multiple nuclear transcription factors belonging to HSP90’s clients in a dose-and cell type-dependent way
  242. celastrol reverses palmitic acid (PA)‐caused TLR4‐MD2 activation‐dependent insulin resistance via disrupting MD2‐related cellular binding to PA
  243. celastrol Reverses Palmitic Acid-Induced Insulin Resistance in HepG2 Cells via Restoring the miR-223 and GLUT4 Pathway
  244. celastrol shows chemopreventive properties in an inflammatory driven model for colon cancer via induction of Nrf2 transcription.
  245. celastrol stimulates hypoxia-inducible factor-1 activity in tumor cells by initiating the ROS/Akt/p70S6K signaling pathway and enhancing hypoxia-inducible …
  246. celastrol strongly inhibits proliferation, migration and cancer stem cell properties through suppression of Pin1 in ovarian cancer cells
  247. celastrol supports survival of retinal ganglion cells injured by optic nerve crush
  248. celastrol suppresses allergen-induced airway inflammation in a mouse allergic asthma model
  249. celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway
  250. celastrol suppresses breast cancer MCF-7 cell viability via the AMP-activated protein kinase (AMPK)-induced p53–polo like kinase 2 (PLK-2) pathway
  251. celastrol suppresses experimental autoimmune encephalomyelitis via MAPK/SGK1-regulated mediators of autoimmune pathology
  252. celastrol suppresses expression of adhesion molecules and chemokines by inhibiting JNK-STAT1/NF-κB activation in poly (I: C)-stimulated astrocytes
  253. celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade in vitro and in vivo
  254. celastrol suppresses IFN-gamma-induced ICAM-1 expression and subsequent monocyte adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells
  255. celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor
  256. celastrol suppresses morphological and transcriptional responses in microglial cells upon stimulation with double-stranded RNA
  257. celastrol suppresses nitric oxide synthases and the angiogenesis pathway in colorectal cancer
  258. celastrol suppresses obesity process via increasing antioxidant capacity and improving lipid metabolism
  259. celastrol suppresses the proliferation of lung adenocarcinoma cells by regulating microRNA-24 and microRNA-181b
  260. celastrol Suppresses Tryptophan Catabolism in Human Colon Cancer Cells as Revealed by Metabolic Profiling and Targeted Metabolite Analysis
  261. celastrol suppresses tumor cell growth through targeting an AR-ERG-NF-κB pathway in TMPRSS2/ERG fusion gene expressing prostate cancer
  262. celastrol synergistically enhances temozolomide cytotoxicity in melanoma cells
  263. celastrol synergizes with oral nifedipine to attenuate hypertension in preeclampsia: a randomized, placebo-controlled, and double blinded trial
  264. celastrol targets IRAKs to block Toll-like receptor 4-mediated nuclear factor-κB activation
  265. celastrol targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent cytotoxicity in tumor cells
  266. celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells
  267. celastrol treatment protects against acute ischemic stroke-induced brain injury by promoting an IL-33/ST2 axis-mediated microglia/macrophage M2 …
  268. Celastrol, a Chinese herbal compound, controls autoimmune inflammation by altering the balance of pathogenic and regulatory T cells in the target organ
  269. Celastrol, a novel HSP90 inhibitor, depletes Bcr–Abl and induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation
  270. Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κB–regulated gene products and TAK1 …
  271. Celastrol, a plant-derived triterpene, induces cisplatin-resistance nasopharyngeal carcinoma cancer cell apoptosis though ERK1/2 and p38 MAPK signaling pathway
  272. Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer’s disease
  273. Celastrol, a proteasome inhibitor, can induce the expression of heat shock protein genes in Xenopus cultured cells
  274. Celastrol, a proteasome inhibitor, can induce the expression of heat shock protein genes in Xenopus laevis A6 kidney epithelial cells
  275. Celastrol, a triterpene extracted from the Chinese “Thunder of God Vine,” is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice
  276. Celastrol, a triterpene extracted from Tripterygium wilfordii Hook F, inhibits platelet activation
  277. Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors
  278. Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors.
  279. Celastrol, a unique multifunctional pharmacophore with multiple targets as an effective therapeutic against ErbB2-overexpressing cancers
  280. Celastrol, an active constituent of the TCM plant Tripterygium wilfordii Hook.f., inhibits prostate cancer bone metastasis
  281. Celastrol, an active constituent of the TCM plant Tripterygium wilfordii, inhibits prostate cancer bone metastasis
  282. Celastrol, an active ingredient in Chinese herbal medicine, radiosensitizes human prostate cancer via modulating NF-kB-signaling pathway
  283. Celastrol, an inhibitor of heat shock protein 90β potently suppresses the expression of matrix metalloproteinases, inducible nitric oxide synthase and cyclooxygenase …
  284. Celastrol, an NF-κB inhibitor, ameliorates hypercalciuria and articular cartilage lesions in a mouse model of secondary osteoporosis
  285. Celastrol, an NF-κB inhibitor, improves insulin resistance and attenuates renal injury in db/db mice
  286. Celastrol, an oral heat shock activator, ameliorates multiple animal disease models of cell death
  287. Celastrol, produced by Tripterygium wilfordii Hook F. enhances defense response in cucumber seedlings against diverse environmental stresses
  288. Celastrol: a new therapeutic potential of traditional Chinese medicine
  289. Celastrol: a spectrum of treatment opportunities in chronic diseases
  290. Celastrol: molecular targets of thunder god vine
  291. Celastrol-based nanomedicines as modulators of neuroinflammation
  292. Celastrol-induced apoptosis in human HaCaT keratinocytes involves the inhibition of NF-κB activity
  293. Celastrol-induced apoptosis in human nasopharyngeal carcinoma is associated with the activation of the death receptor and the mitochondrial pathway
  294. Celastrol-induced degradation of FANCD2 sensitizes pediatric high-grade gliomas to the DNA-crosslinking agent carboplatin
  295. Celastrol-induced Nur77 interaction with TRAF2 alleviates inflammation by promoting mitochondrial ubiquitination and autophagy
  296. Celastrol-induced suppression of the MiR-21/ERK signalling pathway attenuates cardiac fibrosis and dysfunction
  297. Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1
  298. Celastrol-loaded PEG-b-PPS nanocarriers as an anti-inflammatory treatment for atherosclerosis
  299. Celastrol-loaded PEG-PCL nanomicelles ameliorate inflammation, lipid accumulation, insulin resistance and gastrointestinal injury in diet-induced obese mice
  300. Celastrol-modified TiO 2 nanoparticles: effects of celastrol on the particle size and visible-light photocatalytic activity
  301. Celastrol-type HSP90 modulators allow for potent cardioprotective effects
  302. Celastrus and its bioactive celastrol protect against bone damage in autoimmune arthritis by modulating osteoimmune cross-talk
  303. Celastrus-derived celastrol suppresses autoimmune arthritis by modulating antigen-induced cellular and humoral effector responses
  304. Central nervous system effects of celastrol, a potent antioxidant and antiinflammatory agent
  305. Characterization of celastrol to inhibit hsp90 and cdc37 interaction
  306. Chemopreventive activity of celastrol in drug–resistant human colon carcinoma cell cultures
  307. Chronic inhibition of cardiac Kir2. 1 and HERG potassium channels by celastrol with dual effects on both ion conductivity and protein trafficking
  308. Co-Administration of celastrol Can Induce Possible Elevation of Plasma Concentration of Zidovudin (AZT)
  309. Comparative proteome analysis of celastrol-treated Helicobacter pylori
  310. Competitive profiling of celastrol targets in human cervical cancer HeLa cells via quantitative chemical proteomics
  311. Computational investigation of interactions between Cdc37 and celastrol
  312. Control of autoimmune inflammation by celastrol, a natural triterpenoid
  313. Correction to Regiochemistry Discoveries in the Use of Isoxazole as a Handle for the Rapid Construction of an All-Carbon Macrocyclic Precursor in the Synthetic Studies of Celastrol
  314. Correction to: celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells
  315. Correction: celastrol Suppresses Angiogenesis-Mediated Tumor Growth through Inhibition of AKT/Mammalian Target of Rapamycin Pathway
  316. CYP450s-Activity Relations of celastrol to Interact with Triptolide Reveal the Reasons of Hepatotoxicity of Tripterygium wilfordii
  317. Cytotoxic effect of celastrol alone or in combination with paclitaxel on anaplastic thyroid carcinoma cells
  318. Decrease of CD68 synovial macrophages in celastrol treated arthritic rats
  319. Design and synthesis of celastrol derivatives as anticancer agents
  320. Design and synthesis of novel celastrol derivative and its antitumor activity in hepatoma cells and antiangiogenic activity in zebrafish
  321. Design, synthesis and antitumor evaluation of novel celastrol derivatives
  322. Design, synthesis and biological evaluation of C (6)-modified celastrol derivatives as potential antitumor agents
  323. Design, synthesis and biological evaluation of novel C-29 carbamate celastrol derivatives as potent and selective cytotoxic compounds
  324. Determination of celastrol by lanthanide sensitized fluorescence quenching on terbium-ciprofloxacin-SDS.
  325. Development of B Cells and Erythrocytes Is Specifically Impaired by the Drug celastrol in
  326. Development of B cells and erythrocytes is specifically impaired by the drug celastrol in mice
  327. Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids
  328. Discovery of Novel celastrol Derivatives as Hsp90–Cdc37 Interaction Disruptors with Antitumor Activity
  329. Discovery of novel NO-releasing celastrol derivatives with Hsp90 inhibition and cytotoxic activities
  330. Dissecting celastrol with machine learning to unveil dark pharmacology
  331. Docking and molecular dynamics simulations of celastrol binding to p23
  332. Downregulation and subcellular distribution of HER2 involved in MDA-MB-453 breast cancer cell apoptosis induced by lapatinib/celastrol combination
  333. Downregulation of miR-17-92a cluster promotes autophagy induction in response to celastrol treatment in prostate cancer cells
  334. Drug Metabolizing enzymes inhibition-based prediction of celastrol-drugs interaction
  335. EAPH-12. celastrol INDUCED DEGRADATION OF FANCD2 SENSITIZES PEDIATRIC HIGH-GRADE GLIOMA TO THE DNA-CROSSLINKING AGENT …
  336. Early celastrol Administration Prevents Ketamine-Induced Psychotic-Like Behavioral Dysfunctions, Oxidative Stress and IL-10 Reduction in The Cerebellum of Adult …
  337. Effect and Mechanism of celastrol on the Renal Clear Cell Carcinoma 786-0 Cells
  338. Effect and mechanisms of celastrol on the apoptosis of HOS osteosarcoma cells
  339. Effect of celastrol in inhibiting metastasis of lung cancer cells by influencing Akt signaling pathway and expressing integrins
  340. Effect of celastrol in leukocytes from rheumatoid arthritis patients
  341. Effect of celastrol on Akt signaling pathway and apoptosis of leukemic K562 cell line
  342. Effect of celastrol on bone structure and mechanics in arthritic rats
  343. Effect of celastrol on cell cycle arrest and angiogenesis of human multiple myeloma LP-1 cells in vitro [J]
  344. Effect of celastrol on differentiation and maturation of CD_ (14)~+ monocyte-derived dendritic cells
  345. Effect of celastrol on growth inhibition of prostate cancer cells through the regulation of hERG channel in vitro
  346. Effect of celastrol on phagocytosis of neutrophils
  347. Effect of celastrol on temozolomide cytotoxicity in melanoma cells and inhibition of NF-kB signaling
  348. Effect of celastrol on the progression of polycystic kidney disease in a Pkd1-deficient mouse model
  349. Effect of celastrol on toll‑like receptor 4‑mediated inflammatory response in free fatty acid‑induced HepG2 cells
  350. Effect of celastrol postconditioning on focal cerebral ischemia-reperfusion injury in rats
  351. Effective treatment of rat adjuvant-induced arthritis by celastrol
  352. Effects and Mechanisms of celastrol (CSL) on Human Colon Cancer Cell Line HCT-116 in vitro [J]
  353. Effects of celastrol in a mouse model of pulmonary hypertension associated with bronchopulmonary dysplasia induced by hyperoxia
  354. Effects of celastrol on Accelerated Healing of Skin Wounds of Diabetic Ulceration in Rats and Mechanism Revealed by Nuclear Magnetic Resonance-based …
  355. Effects of celastrol on Bv-2 Microglial Cells Exposed to in Vitro Hypoxia
  356. Effects of celastrol on enhancing apoptosis of ovarian cancer cells via the downregulation of microRNA‑21 and the suppression of the PI3K/Akt‑NF‑κB …
  357. Effects of celastrol on human cervical cancer cells as revealed by ion-trap gas chromatography–mass spectrometry based metabolic profiling
  358. EFFECTS OF celastrol ON IL-1 AND lL-2 PRODUCTION
  359. Effects of celastrol on Tau hyperphosphorylation and expression of HSF‐1 and HSP70 in SH‐SY5Y neuroblastoma cells induced by amyloid‐β peptides
  360. Effects of celastrol on the Collagen, Macrophage Migration Inhibitory Factor and Matrix Metalloproteinase-9 Expressions in the Plaque of ApoE Gene Knockout Mice …
  361. Effects of celastrol on the expression of CD40 ligand and number of macrophages and smooth muscle cells in the atherosclerotic plaques of ApoE gene knockout …
  362. Effects of celastrol on the Expression of C-reactive Protein and Tissue Factor in the Aorta of ApoE Gene Knockout Mice [J]
  363. Effects of demethylzeylasteral and celastrol on spermatogenic cell Ca2+ channels and progesterone-induced sperm acrosome reaction
  364. Effects of diclofenac on the pharmacokinetics of celastrol in rats and its transport
  365. Effects of environmental stresses on celastrol contents in Tripterygium wilfordii.
  366. Efficacy and toxicity evaluation of celastrol in adjuvant-induced arthritis rat model
  367. Efficacy of celastrol combined with cisplatin in enhancing the apoptosis of U‑2OS osteosarcoma cells via the mitochondrial and endoplasmic reticulum …
  368. Efficacy, pharmacokinetics and tissue distribution of celastrol analogues SBI 064601, SBI 0640599 and SBI 0069272 in CB-17 SCID mice bearing Daudi Burkitt’s …
  369. Elucidation of the intestinal absorption mechanism of celastrol using the Caco-2 cell transwell model
  370. Enhanced Autophagy by celastrol Supplementation Profoundly Increases Angiotensin II-induced Abdominal Aortic Aneurysm Formation in Male and Female Mice
  371. Enhanced cancer therapy of celastrol in vitro and in vivo by smart dendrimers delivery with specificity and biosafety
  372. Enhancement of radiation sensitivity in lung cancer cells by celastrol is mediated by inhibition of Hsp90
  373. ER stress-mediated apoptosis induced by celastrol in cancer cells and important role of glycogen synthase kinase-3β in the signal network
  374. Erratum for: Elucidation of the Intestinal Absorption Mechanism of celastrol Using the Caco-2 Cell Transwell Model.
  375. Erratum to: celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor
  376. Evaluation of anticancer activity of celastrol liposomes in prostate cancer cells
  377. Evaluation of connectivity map-discovered celastrol as a radiosensitizing agent in a murine lung carcinoma model: Feasibility study of diffusion-weighted …
  378. Evaluation of Neuroprotective Effect of celastrol in Optic Nerve Crush Model
  379. Exosomal formulation enhances therapeutic response of celastrol against lung cancer
  380. Folate receptor-mediated celastrol and irinotecan combination delivery using liposomes for effective chemotherapy
  381. Formulation and evaluation of celastrol-loaded liposomes
  382. FRI0367 celastrol Inhibits Osteoclastogenesis and Bone Resorption in Rankl-Induced Raw264. 7 via Nf-κB and MAPK Pathways and Attenuates Bone Erosion in …
  383. Friedelane‐type triterpene cyclase in celastrol biosynthesis from Tripterygium wilfordii and its application for triterpenes biosynthesis in yeast
  384. Gambogic acid and celastrol are two powerful anti-inflammatory drugs in arthritis
  385. Genetic transformation system for woody plant Tripterygium wilfordii and its application to product natural celastrol
  386. Gold nanourchins and celastrol reorganize the nucleo-and cytoskeleton of glioblastoma cells
  387. GW27-e0848 Effect of celastrol on Insulin Resistance and ROS/IKK Signaling Pathway in Vascular Endothelial Cells
  388. Herbal Component celastrol is an Inhibitor of UDP-Glucuronosyltransferase (UGT) 1A7
  389. Heterogeneity in the properties of NEFL mutants causing Charcot–Marie–Tooth disease results in differential effects on neurofilament assembly and susceptibility to intervention by the chaperone-inducer, celastrol
  390. High-throughput study of the effects of celastrol on activated fibroblast-like synoviocytes from patients with rheumatoid arthritis
  391. HPLC-MS/MS Determination of Trace Amount of celastrol in Urine After Purification with Solid-Phase Extraction [J]
  392. Hsp90 inhibitor celastrol reinstates growth plate angiogenesis in thiram-induced tibial dyschondroplasia
  393. HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way
  394. Identification of celastrol as a Novel YAP-TEAD Inhibitor for Cancer Therapy by High Throughput Screening with Ultrasensitive YAP/TAZ–TEAD Biosensors
  395. Identification of Metabolites from Triptolide and celastrol in Rats
  396. Improvement of mitochondrial function by celastrol in palmitate-treated C2C12 myotubes via activation of PI3K-Akt signaling pathway
  397. Improving Dissolution Properties by Polymers and Surfactants: A Case Study of Celastrol
  398. IN VITRO 3D PHENOTYPIC DRUG SCREEN IDENTIFIES celastrol AS AN EFFECTIVE IN VIVO INHIBITOR OF POLYCYSTIC KIDNEY DISEASE
  399. In vitro and in vivo anti-tumor effects of a combination therapy of curcumin and celastrol to gastric cancer
  400. In vitro immunomodulatory activity of celastrol against influenza A virus infection
  401. In vitro inhibition of celastrol on spermatozoa fertilization ability of guinea pig
  402. Induction of heat shock proteins in cerebral cortical cultures by celastrol
  403. Induction of heat shock proteins in differentiated human and rodent neurons by celastrol
  404. Induction of heat shock proteins in differentiated human neuronal cells following co-application of celastrol and arimoclomol
  405. Inductive Effect of celastrol on Apoptosis of Human Multiple Myeloma Cell Line LP-1 [J]
  406. Inflammation-Targeted Delivery of celastrol via Neutrophil Membrane-Coated Nanoparticles in the Management of Acute Pancreatitis
  407. Influence of celastrol on toll-like receptor 4-mediated signaling pathway in the free fatty acids-induced HepG2 cells
  408. Inhibiting Effect of celastrol on Immune Responses
  409. Inhibiting inducible miR-223 further reduces viable cells in human cancer cell lines MCF-7 and PC3 treated by celastrol
  410. Inhibition of anthrax lethal toxin-induced cytolysis of RAW264. 7 cells by celastrol
  411. Inhibition of autophagy strengthens celastrol-induced apoptosis in human pancreatic cancer in vitro and in vivo models
  412. Inhibition of C2C12 myotube atrophy by a novel HSP70 inducer, celastrol, via activation of Akt1 and ERK1/2 pathways
  413. Inhibition of c-myc by the triterpenoid celastrol
  414. Inhibition of IKKβ by celastrol and its analogues – an in silico and in vitro approach
  415. Inhibition of inflammation with celastrol fails to improve muscle function in dysferlin-deficient A/J mice
  416. Inhibition of NF-κB activation through targeting IκB kinase by celastrol, a quinone methide triterpenoid
  417. Inhibition of proliferation of adult T-cell leukemia cells by celastrol
  418. Inhibitory action of celastrol on hypoxia-mediated angiogenesis and metastasis via the HIF-1α pathway
  419. Inhibitory effect of celastrol on adipogenic differentiation of human adipose-derived stem cells
  420. Inhibitory effect of celastrol on cell viability of urinary bladder cancer cell line 5637 cells through JAK2/STAT3 signaling pathway
  421. Inhibitory effects of celastrol on primary hepatocytes of HBV transgenic mice
  422. Inhibitory effects of celastrol on rat liver cytochrome P450 1A2, 2C11, 2D6, 2E1 and 3A2 activity
  423. Inhibitory mechanisms of celastrol on human liver cytochrome P450 1A2, 2C19, 2D6, 2E1 and 3A4
  424. Integrated metabolomics and network toxicology to reveal molecular mechanism of celastrol induced cardiotoxicity
  425. Investigation of the influence of glycyrrhizin on the pharmacokinetics of celastrol in rats using LC-MS and its potential mechanism
  426. Lack of neuroprotective effect of celastrol under conditions of proteasome inhibition by lactacystin in in vitro and in vivo studies: implications for Parkinson’s …
  427. LC–APCI–MS–MS for the Determination of celastrol in Human Whole Blood
  428. Leptin sensitizer celastrol, glial calcineurin and hypothalamic glutathione peroxidase 7-novel entities in weight control and glucose homeostasis
  429. Lipids: celastrol protects against fatty liver through SIRT1
  430. Lipocalin 2 Does Not Play A Role in Celastrol-Mediated Reduction in Food Intake and Body Weight
  431. LKB1 and YAP phosphorylation play important roles in Celastrol-induced β-catenin degradation in colorectal cancer
  432. Loading of water-insoluble celastrol into niosome hydrogels for improved topical permeation and anti-psoriasis activity
  433. Localization of heat shock proteins in cerebral cortical cultures following induction by celastrol
  434. Mechanism of action of celastrol against rheumatoid arthritis: A network pharmacology analysis
  435. Medicinal Compound celastrol As a Potential Clinical Anticancer Drug: Lessons Learned From Preclinical Studies
  436. Metabolomics profiles delineate uridine deficiency contributes to mitochondria-mediated apoptosis induced by celastrol in human acute promyelocytic …
  437. Metabolomics Reveals Cysteine Metabolism Plays a Role in Celastrol-Induced Mitochondrial Apoptosis of Acute Promyelocytic Leukemia Cells
  438. Microarray-based gene expression profiling reveals the mediators and pathways involved in the anti-arthritic activity of Celastrus-derived Celastrol
  439. miR-224 is critical for celastrol-induced inhibition of migration and invasion of hepatocellular carcinoma cells
  440. miR-33a-5p enhances the sensitivity of lung adenocarcinoma cells to celastrol by regulating mTOR signaling
  441. Mitochondrial alkaline pH-responsive drug release mediated by celastrol loaded glycolipid-like micelles for cancer therapy
  442. Modulation of inflammatory signaling and cytokine release from microglia by celastrol incorporated into dendrimer nanocarriers
  443. Modulation of lipid metabolism by celastrol
  444. Modulatory effect of celastrol on Th1/Th2 cytokines profile, TLR2 and CD3+ T-lymphocyte expression in a relapsing–remitting model of multiple sclerosis in rats
  445. Molecular mechanism of celastrol in the treatment of systemic lupus erythematosus based on network pharmacology and molecular docking technology
  446. Molecular mechanism of inhibition of the human protein complex Hsp90–Cdc37, a kinome chaperone–cochaperone, by triterpene celastrol
  447. Molecular modulators of celastrol as the keystones for its diverse pharmacological activities
  448. Molecular Studies on Celastrol-induced Bcr-Abl Oncoprotein Degradation in Human Leukemia Cells
  449. Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer
  450. Molecular targets of celastrol in cancer: Recent trends and advancements
  451. Mutations Y493G and K546D in human HSP 90 disrupt binding of celastrol and reduce interaction with Cdc37
  452. NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action
  453. Nanoencapsulation of natural triterpenoid celastrol for prostate cancer treatment
  454. Nascent RNA sequencing reveals a dynamic global transcriptional response at genes and enhancers to the natural medicinal compound celastrol
  455. Natural product celastrol destabilizes tubulin heterodimer and facilitates mitotic cell death triggered by microtubule-targeting anti-cancer drugs
  456. Natural product celastrol suppressed macrophage M1 polarization against inflammation in diet-induced obese mice via regulating Nrf2/HO-1, MAP kinase and …
  457. Natural products triptolide, celastrol, and withaferin A inhibit the chaperone activity of peroxiredoxin I
  458. Natural Proteasome Inhibitor celastrol Suppresses Androgen-Independent Prostate Cancer
  459. Natural proteasome inhibitor celastrol suppresses androgen-independent prostate cancer progression by modulating apoptotic proteins and NF-kappaB
  460. New strategy of photodynamic treatment of TiO 2 nanofibers combined with celastrol for HepG2 proliferation in vitro
  461. NF-kappa B modulation is involved in celastrol induced human multiple myeloma cell apoptosis
  462. NF-kB Inhibition via Celastrol-Loaded Nanocarriers Induces Distinct Changes in Atheroma-Resident Immune Cell Composition in Male vs. Female ldlr-/-Mice
  463. Non-triggered sequentially-released liposomes enhance anti-breast cancer efficacy of STS and celastrol-based microemulsion
  464. Non-triggered sequential-release liposomes enhance anti-breast cancer efficacy of STS and celastrol-based microemulsion
  465. Novel celastrol derivatives inhibit the growth of hepatocellular carcinoma patient-derived xenografts
  466. Novel celastrol derivatives with improved selectivity and enhanced antitumour activity: Design, synthesis and biological evaluation
  467. Novel low-toxic derivative of celastrol maintains protective effect against acute renal injury
  468. Optimization and biological evaluation of celastrol derivatives as Hsp90–Cdc37 interaction disruptors with improved druglike properties
  469. Optimization of Preparation and Preclinical Pharmacokinetics of Celastrol-Encapsulated Silk Fibroin Nanoparticles in the Rat
  470. Optimized preparation of celastrol-loaded polymeric nanomicelles using rotatable central composite design and response surface methodology
  471. Oral bioavailability and gender-related pharmacokinetics of celastrol following administration of pure celastrol and its related tablets in rats
  472. Overcoming cisplatin resistance by celastrol in cancer cells.
  473. Overexpression and RNAi-mediated downregulation of TwIDI regulates triptolide and celastrol accumulation in Tripterygium wilfordii
  474. P52. The IKK inhibitors celastrol and parthenolide inhibit breast cancer cell proliferation and migration in vitro and osteolytic bone metastasis in vivo
  475. Paraptosis accompanied by autophagy and apoptosis was induced by celastrol, a natural compound with influence on proteasome, ER stress and Hsp90
  476. Paraptosis accompanied by autophagy and apoptosis was induced by celastrol, a natural compound with influence on proteasome, ER stress and Hsp90.
  477. PEGylated lipid bilayer-supported mesoporous silica nanoparticle composite for synergistic co-delivery of axitinib and celastrol in multi-targeted cancer therapy
  478. PEGylated polyaminoacid-capped mesoporous silica nanoparticles for mitochondria-targeted delivery of celastrol in solid tumors
  479. Pharmacogenomic approach reveals a role for the xc− cystine/glutamate antiporter in growth and celastrol resistance of glioma cell lines
  480. Pharmacological induction of Heat Shock Protein 70 by celastrol protects motoneurons from excitotoxicity in rat spinal cord in vitro
  481. Plant-derived triterpene celastrol ameliorates oxygen glucose deprivation-induced disruption of endothelial barrier assembly via inducing tight junction proteins
  482. Potent suppression of both spontaneous and carcinogen-induced colitis-associated colorectal cancer in mice by dietary celastrol supplementation
  483. PRECLINICAL EVALUATION OF celastrol AS A PHARMACOLOGICAL DRUG CANDIDATE FOR INFARCT SIZE REDUCTION
  484. Preclinical studies of celastrol and acetyl isogambogic acid in melanoma
  485. Pre-conditioning of stem cell with celastrol to enhance their therapeutical potential
  486. Prediction of Drug-Drug Interaction Due to the Inhibition of Specific Intestinal Drug-Metabolizing Enzymes by Celastrol
  487. Preliminary study on cardiotoxicity of celastrol to zebrafish embryo
  488. Preliminary study on fabrication, characterization and synergistic anti-lung cancer effects of self-assembled micelles of covalently conjugated celastrol–polyethylene glycol–ginsenoside Rh2
  489. Preparation, characterization and cytotoxic evaluation of inclusion complexes between celastrol with polyamine-modified β-cyclodextrins
  490. Preparation, characterization, and assessment of the antiglioma effects of liposomal celastrol
  491. Preparative isolation and purification of celastrol from Celastrus orbiculatus Thunb. by a new counter-current chromatography method with an upright coil planet …
  492. Preventive Effects of “Ovalbumin-Conjugated Celastrol-Loaded Nanomicelles” in a Mouse Model of Ovalbumin-Induced Allergic Airway Inflammation
  493. Production of Tripterygium regelii differentiated biomass as a sustainable source of celastrol
  494. Prooxidative Activity of celastrol Induces Apoptosis, DNA Damage, and Cell Cycle Arrest in Drug-Resistant Human Colon Cancer Cells
  495. Protective effect of celastrol for burn-induced acute lung injury in rats
  496. Protective effect of celastrol in rat cerebral ischemia model: down-regulating p-JNK, pc-Jun and NF-κB
  497. Protective effect of celastrol on allergic rhinitis in rats
  498. Protective effect of celastrol on myocardial ischemia–reperfusion injury
  499. Protective effects of celastrol against γ irradiation‑induced oxidative stress in human umbilical vein endothelial cells
  500. Protective effects of celastrol on diabetic liver injury via TLR4/MyD88/NF-κB signaling pathway in type 2 diabetic rats
  501. Protective effects of celastrol on diethylnitrosamine-induced hepatocellular carcinoma in rats and its mechanisms
  502. Protective Effects of Celastrol, the Triterpenoid Component of Celastrus Orbiculatus, on Dopaminergic Neuronal Cells in 1-methyl-4-phenyl-1, 2, 3, 6 …
  503. Quantitative bioimage analytics enables measurement of targeted cellular stress response induced by celastrol-loaded nanoparticles
  504. Quantitative proteomics reveals cellular targets of celastrol
  505. Quinone methide tripterine, celastrol, induces apoptosis in human myeloma cells via NF-κB pathway
  506. Radiosensitization by celastrol is mediated by modification of antioxidant thiol molecules
  507. Reduction of β-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer’s disease
  508. Regiochemistry discoveries in the use of isoxazole as a handle for the rapid construction of an all-carbon macrocyclic precursor in the synthetic studies of celastrol
  509. Regulation of Transforming Growth Factor‐β/Smad‐mediated Epithelial–Mesenchymal Transition by celastrol Provides Protection against Bleomycin‐induced …
  510. Release of Ca2+ from the endoplasmic reticulum and its subsequent influx into mitochondria trigger celastrol-induced paraptosis in cancer cells
  511. Remarkable stereospecific conjugate additions to the Hsp90 inhibitor celastrol
  512. Repression of acetaminophen-induced hepatotoxicity by a combination of celastrol and brilliant blue G
  513. Research progress in pharmacologic molecular targets of celastrol
  514. Research Progress on the Anti-tumor Effect of Celastrol
  515. Role of celastrol in Chemosensitization of Cancer
  516. Role of celastrol in Regulating Proliferation and Apoptosis of Lung Cancer Cell
  517. Role of the eIF4E binding protein 4E‐BP1 in regulation of the sensitivity of human pancreatic cancer cells to TRAIL and celastrol‐induced apoptosis
  518. SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway
  519. Self-assembled phospholipid-based phytosomal nanocarriers as promising platforms for improving oral bioavailability of the anticancer celastrol
  520. Separation, identification and quantitative determination of celastrol from the root bark of Celastrus hookeri
  521. Simultaneous determination of triptolide, tripterifordin, celastrol and nine sesquiterpene alkaloids in Tripterygium preparations using high-performance liquid …
  522. Simultaneous NF‐κB inhibition and E‐cadherin upregulation mediate mutually synergistic anticancer activity of celastrol and SAHA in vitro and in vivo
  523. Simultaneous targeting therapy for lung metastasis and breast tumor by blocking the NF-κB signaling pathway using celastrol-loaded micelles
  524. Small Molecule Induction of the Heat Shock Response: Cytoprotective Effects and Potential Clinical Applications of Celastrol
  525. Solid self-microemulsifying dispersible tablets of celastrol: Formulation development, charaterization and bioavailability evaluation
  526. Strong inhibition of celastrol towards UDP-glucuronosyl transferase (UGT) 1A6 and 2B7 indicating potential risk of UGT-based herb-drug interaction
  527. Structural basis of potent antiperoxidation activity of the triterpene celastrol in mitochondria: effect of negative membrane surface charge on lipid peroxidation
  528. Structure of Pristimerin and Celastrol
  529. Studies toward the synthesis of celastrol and the late-stage hydroxylation of arenes mediated by 4, 5-dichlorophthaloyl peroxide
  530. Study of celastrol on akt signaling pathway and its roles in the apoptosis of K562 cells
  531. Study on Extraction and Purification of celastrol from C. Anticulatus Thunb
  532. Study on Preparation of celastrol Ethosome and Its Skin Penetration Properties in Vitro
  533. Study on the Effects and Mechanism of celastrol on Proliferation and Apoptosis of Human Hepatoma HepG2 Cells in vitro
  534. Sugar-decorated mesoporous silica nanoparticles as delivery vehicles for the poorly soluble drug celastrol enables targeted induction of apoptosis in cancer cells
  535. SUN-096 Hypothalamic ATP Has a Crucial Role in the Pathogenesis of Leptin Resistance: A Potential Mechanism for the Amelioration of Leptin Resistance by celastrol and Withaferin A
  536. Suppression of autoimmune arthritis by Celastrus-derived celastrol through modulation of pro-inflammatory chemokines
  537. Suppression of inflammatory responses by celastrol, a quinone methide triterpenoid isolated from Celastrus regelii
  538. Synergism between NF-kappa B inhibitor, celastrol, and XIAP inhibitor, embelin, in an acute myeloid leukemia cell line, HL-60
  539. Synergistic anti-cancer activity by the combination of TRAIL/APO-2L and celastrol
  540. Synergistic anticancer effects of triptolide and celastrol, two main compounds from thunder god vine
  541. Synergistic combination chemotherapy using carrier-free celastrol and doxorubicin nanocrystals for overcoming drug resistance
  542. Synthesis and anti-cancer evaluation of novel celastrol analogues
  543. Synthesis and anti-tumor activity study of water-soluble PEG-celastrol coupling derivatives as self-assembled nanoparticles
  544. Synthesis and biological evaluation of a series of novel celastrol derivatives with amino acid chain
  545. Synthesis and biological evaluation of celastrol derivatives as anti-ovarian cancer stem cell agents
  546. Synthesis and characterisation of celastrol derivatives as potential anticancer agents
  547. Synthesis and preliminary evaluation of neuroprotection of celastrol analogues in PC12 cells
  548. Synthesis of 3-and 29-substituted celastrol derivatives and structure-activity relationship studies of their cytotoxic activities
  549. Synthetic studies on a novel celastrol-fluo-rescent probe for in vivo imaging and novel amination methodologies
  550. Systematic identification of Celastrol-binding proteins reveals that Shoc2 is inhibited by Celastrol
  551. Targeted delivery of celastrol to mesangial cells is effective against mesangioproliferative glomerulonephritis
  552. Targeting b1 integrin, celastrol as a potent anti-metastatic agent, inhibits cell-ECM adhesion, partially via the p38 MAPK pathway
  553. Targeting Mast Cells and Basophils with Anti-FcεRIα Fab-Conjugated Celastrol-Loaded Micelles Suppresses Allergic Inflammation
  554. Targeting the osteoarthritis via the combination of TCM Celastrol, novel modified mirna and rapalogue
  555. TAZ promotes cell growth and inhibits Celastrol-induced cell apoptosis
  556. The Anti-cancer effects of celastrol on K562 cell line
  557. The cellular labeling and pH-sensitive responsive-drug release of celastrol in cancer cells based on Cys-CdTe QDs
  558. The effect of celastrol on learing and memory in mice after artiacl hepatectomy
  559. The effect of celastrol on learning and memory in diabetic rats after sevoflurane inhalation
  560. The effect of celastrol on the expressions of RANKL, OPG, IL-6, TNF-α and IL-8 in human rheumatoid synoviocyte MH7A [J]
  561. The effect of celastrol on the ocular hypertension-induced degeneration of retinal ganglion cells
  562. The effect of celastrol, a triterpene with antitumorigenic activity, on conformational and functional aspects of the human 90 kDa heat shock protein Hsp90α, a …
  563. The experimental studies of celastrol on the reversal of multidrug resistance in K562/A02 cell line
  564. The impact of celastrol on cognitive function and expressions of Aβ40 and Aβ42 in hippocampus in APPswe/PS1dE9 double transgenic mouse after partial …
  565. The inhibitive effects of celastrol on LDL oxidation and HAEC cell oxidative damage
  566. The inhibitory effects of celastrol on proliferation, invasion and migration of human pancreatic cancer cell line PANC-1
  567. The leptin sensitizer celastrol reduces age‐associated obesity and modulates behavioral rhythms
  568. The MVA pathway genes expressions and accumulation of celastrol in Tripterygium wilfordii suspension cells in response to methyl jasmonate treatment
  569. The natural anti-tumor compound celastrol targets a Myb-C/EBPβ-p300 transcriptional module implicated in myeloid gene expression
  570. The natural compound celastrol inhibits necroptosis and alleviates ulcerative colitis in mice
  571. THE NATURAL PROTEASOME INHIBITOR celastrol CAN ACCELERATE DNA REPAIR IN HUMAN LYMPHOCYTES
  572. The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma
  573. The NF-κB inhibitor celastrol attenuates acute hepatic dysfunction induced by cecal ligation and puncture in rats
  574. The plant triterpenoid celastrol blocks PINK1-dependent mitophagy by disrupting PINK1’s association with the mitochondrial protein TOM20
  575. The research of celastrol on its effect of inducing gastric cancer cell line MGC803 apoptosis [J]
  576. The ROS derived mitochondrial respirstion not from NADPH oxidase plays key role in celastrol against angiotensin II-mediated HepG2 cell proliferation
  577. The suppressive effect of celastrol against Multiple Myeloma Cell Line RPMI8226 in vitro [J]
  578. The therapeutic potential of pharmacological chaperones and proteosomal inhibitors, celastrol and MG132 in the treatment of sialidosis
  579. The Transannular bis-Michael Reaction in the Synthetic Studies of celastrol and the Development of Novel Palladium-Catalyzed Reactions
  580. The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria
  581. The use of celastrol in the fight against obesity
  582. Therapeutic Effects and Related Molecular Mechanisms of Celastrol, a Triterpenoid Natural Compound and Novel HSP90 Inhibitor Extracted from Plants of the …
  583. Therapeutic effects of celastrol on DEN induced liver fibrosis rats and its mechanisms
  584. Total synthesis of celastrol, development of a platform to access celastroid natural products
  585. Toxic effects of celastrol on embryonic development of zebrafish (Danio rerio)
  586. Transdermal delivery system of nanostructured lipid carriers loaded with celastrol and Indomethacin: optimization, characterization and efficacy evaluation for …
  587. Transferrin-functionalised microemulsion co-delivery of β-elemene and celastrol for enhanced anti-lung cancer treatment and reduced systemic toxicity
  588. Treatment of obesity with celastrol
  589. Treatment with celastrol protects against obesity through suppression of galanin-induced fat intake and activation of pgc-1α/glut4 axis-mediated glucose consumption
  590. Triptolide and celastrol loaded silk fibroin nanoparticles show synergistic effect against human pancreatic cancer cells
  591. Ultrasound-assisted ionic liquid dispersive liquid–liquid microextraction coupled with high performance liquid chromatography for sensitive determination of trace celastrol in urine
  592. UPLC-Q-TOF-MS-based metabolomics study of celastrol
  593. Upregulating Noxa by ER stress, celastrol exerts synergistic anti-cancer activity in combination with ABT-737 in human hepatocellular carcinoma cells
  594. Up-regulation of death receptor 4 and 5 by celastrol enhances the anti-cancer activity of TRAIL/Apo-2L
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