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SUPER HAIR GROWTH COMBO SAMPLER – $1400 VALUE FOR $575(SAVE 59%)

Price Each:

$350.00$575.00

SKU: HAIR-SAMP-100 Categories: , ,

$1400 VALUE for $575! Save 59%!

350g (50g x 7) = approx 144 1/8 tsp servings of each blend.




SUPER

hair growth

PROTOCOL

How does it work? 

INSULIN blocks SHBG

SHBG blocksDHT

⬇️ LOW INSULIN =

⬆️ HIGH SHBG =

⬇️ LOW DHT =

THICK, STRONG, HEALTHY, FAST GROWING HAIR!

✨❤️✨

The OPPOSITE looks like this:

⬆️ High blood sugar =

⬇️ Low insulin sensitivity =

⬆️ High insulin secretion =

⬇️ Low SHBG = 

⬆️ High DHT =

Frail, thinning hair and baldness

Low sex‐hormone binding globulin levels in young women with diffuse hair loss

We measured plasma sex-hormone binding globulin (SHBG ) and testosterone levels in a pilot study of eight women aged 21–41 years who complained of diffuse hair loss; and subsequently in a larger group of fifteen patients of a similar age range. There was a significant reduction in SHBG levels in both groups of patients when compared to controls, but testosterone values were normal.

Sex hormone‐binding globulin levels in men with androgenetic alopecia

Sex hormone binding globulin (SHBG ), plasma testosterone and saliva testosterone were measured in sixty‐four men with androgenetic alopecia and in forty males within the same age range without alopecia . There was a significant reduction in SHBG levels in bald men, compared with controls. Plasma testosterone levels were not raised in bald men, but their salivary testosterone levels were significantly higher than in controls.

Androgens play an important role in the pathogenesis of androgenetic alopecia (Ebling & Rook, 1979), but no correlation has been found between the plasma androgen level and androgenetic alopecia (Burton et al., 1979). In order to clarify this point we have studied plasma testosterone , saliva testosterone and plasma sex hormone binding globulin (SHBG ) levels in a group of males with androgenetic alopecia.

Hormonal Profile of Men with premature balding

There was a significant reduction in SHBG levels in bald men, compared with controls significantly lower SHBG values in balding men. Low SHBG is often associated with insulin resistance or hyperinsulinaemia. Another possible cause of the increased androgen effect on the dermal papilla of balding men

Results: The frequency of subnormal values in SHBG , FSH, testos-terone and epi testosterone (but not in free androgen index) was significant in the balding men. A borderline significant trend was recorded with respect to increased levels in 17OH-P and prolac- tin. Conclusions: The hormonal pattern of a substantial number of men with premature balding resembles in some respects the hormonal pattern of women with polycystic ovary syndrome.

Inhibition of sex hormone-binding globulin Production in the Human Hepatoma (Hep G2) Cell Line by insulin and Prolactin

Sex hormone-binding globulin (SHBG) production in humans has been thought to be stimulated by estrogens and thyroid hormone and inhibited by androgens. However, recent data indicate that SHBG production in vitro is stimulated by both androgens and estrogens. This study was designed to determine what other hormonal factors regulate SHBG production. Since hyperinsulinemia and hyperprolactinemia both occur in disease states in which low serum SHBG levels are found, the effects of insulin and PRL were compared to and/or studied in combination with estradiol (E2,) T4, and testosterone (T) in a human hepatoma cell line (Hep G2). Hep G2 cells were grown to near confluence in medium including 10% fetal calf serum, and then 72-h experimental incubations were carried out which used only fetal calf serum-free medium.

Compared to control incubations, both insulin (10−8 mol/L) and PRL (10−8 mol/L) decreased SHBG production from 65.0 ± 0.6 (±se) to 46.8 ± 1.1 and 46.8 ± 1.2 nmol/108 cells, respectively (P < 0.01). insulin also inhibited both E2 and T4-stimulated SHBG production. T stimulated SHBG production to the same degree as E2.

Finally, both E2 and insulin significantly increased cell number, an important consideration when expressing the effect of a hormone on SHBG production in cultured cells. We conclude that insulin and PRL inhibit SHBG production and confirm that T4, T, and E2 stimulate SHBG production in vitro. These findings suggest that insulin and PRL may be important factors in the regulation of SHBG production in vivo. (J Clin Endocrinol Metab67: 460, 1988

To correct hair loss you need to correct insulin resistance and hyperinsulinemia.

GLUCOSE BLOCKER

LIVER REGENERATOR

Low levels of sex hormone-binding globulin and hyperinsulinemia as markers of increased pancreatic ß-cell demand in men

SciELO – Brazil – Low levels of sex hormone-binding globulin and hyperproinsulinemia as markers of increased pancreatic ß-cell demand in men. Low levels of sex hormone-binding globulin (SHBG) are considered to be an indirect index of hyperinsulinemia, predicting the later onset of diabetes mellitus type 2. In the insulin resistance state and in the presence of an increased pancreatic ß-cell demand (e.g. obesity) both absolute and relative increases in proinsulin secretion occur.

In the present study we investigated the correlation between SHBG and pancreatic ß-cell secretion in men with different body compositions. Eighteen young men (30.0 ± 2.4 years) with normal glucose tolerance and body mass indexes (BMI) ranging from 22.6 to 43.2 kg/m2 were submitted to an oral glucose tolerance test (75 g) and baseline and 120-min blood samples were used to determine insulinproinsulin and C-peptide by specific immunoassays. Baseline SHBG values were significantly correlated with baseline insulin (r = -0.58, P<0.05), proinsulin (r = -0.47, P<0.05), C-peptide (r = -0.55, P<0.05) and also with proinsulin at 120 min after glucose load (r = -0.58, P<0.05). Stepwise regression analysis revealed that proinsulin values at 120 min were the strongest predictor of SHBG (r = -0.58, P<0.05).

When subjects were divided into obese (BMI >28 kg/m2, N = 8) and nonobese (BMI <FONT FACE=”Symbol”>£</FONT>25 kg/m2, N = 10) groups, significantly lower levels of SHBG were found in the obese subjects. The obese group had significantly higher baseline proinsulin, C-peptide and 120-min proinsulin and insulin levels. For the first time using a specific assay for insulin determination, a strong inverse correlation between insulinemia and SHBG levels was confirmed.

The finding of a strong negative correlation between SHBG levels and pancreatic ß-cell secretion, mainly for the 120-min post-glucose load proinsulin levels, reinforces the concept that low SHBG levels are a suitable marker of increased pancreatic ß-cell demand.

A cell-based system for screening hair growth -promoting agents

APIGENIN keeps your hair in anagen growth phase; pair with SUPER TONIC hair.

“Furthermore, apigenin stimulated the elongation of hair follicles. Taken together, these findings suggest that apigenin, which is known to have antioxidant, anti-inflammatory, and anti-tumor properties, stimulates hair growth through downregulation of the TGF-beta 1 gene.”

Androgen-inducible transforming growth factor beta (TGF-beta 1) derived from dermal papilla cells (DPCs) is a catagen inducer that mediates hair growth suppression in androgenetic alopecia (AGA). In this study, a cell-based assay system was developed to monitor TGF-beta 1 promoter activity and then used to evaluate the effects of activated TGF-beta 1 promoter in human epidermal keratinocytes (HaCaT). To accomplish this, a pMetLuc-TGF-beta 1 promoter plasmid that expresses the luciferase reporter gene in response to TGF-beta 1 promoter activity was constructed. Treatment of HaCaT with dihydrotestosterone , which is known to be a primary factor of AGA, resulted in a concentration-dependent increase in TGF-beta 1 promoter activity. However, treatment of HaCaT with the TGF-beta 1 inhibitor, curcumin, resulted in a concentration-dependant decrease in TGF-beta 1 expression.

Subsequent use of this assay system to screen TGF-beta 1 revealed that HaCaT that were treated with apigenin showed decreased levels of TGF-beta 1 expression. In addition, treatment with apigenin also significantly increased the proliferation of both SV40T-DPCs (human DPCs) and HaCaT cells. Furthermore, apigenin stimulated the elongation of hair follicles in a rat vibrissa hair follicle organ culture.

Taken together, these findings suggest that apigenin, which is known to have antioxidant, anti-inflammatory, and anti-tumor properties, stimulates hair growth through downregulation of the TGF-beta 1 gene. In addition, these results suggest that this assay system could be used to quantitatively measure TGF-beta 1 promoter activity in HaCaT, thereby facilitating the screening of agents promoting hair growth.

Mechanism of action of herbs and their active constituents used in hair loss treatment

This article discusses the mechanisms via topically applied products containing herbs and their active constituents affect the hair growth process. It was reported that the mechanisms involving (1) insulin-like growth factor-I (IGF-I), (2) vascular endothelial growth factor (VEGF), (3) epidermal growth factor (EGF), (4) fibroblast growth factor 2 (FGF-2), (5) endothelial nitric oxide synthase (eNOS), (6) Wnt/β-catenin signalling pathway, (7) prostaglandin E (PGE), (8) prostaglandin F (PGF) stimulate hair growth, whereas the mechanisms engaging (1) 5α-reductase and dihydrotestosterone (DHT), (2) transforming growth factor beta (TGF-β), (3) fibroblast growth factor 5 (FGF-5), (4) prostaglandin D2 (PGD2) inhibit hair growth. The knowledge summarized in the paper may be an inspiration to create new preparations for the treatment of hair loss.

The flavonoid luteolin inhibits niacin-induced flush

Background and purpose: Sustained release niacin effectively lowers serum cholesterol, LDL and triglycerides, while raising HDL. However, 75% of patients experience cutaneous warmth and itching known as flush, leading to discontinuation. Acetylsalicylic acid (aspirin) reduces this flush only by about 30%, presumably through decreasing prostaglandin D2 (PGD2). We investigated whether niacin-induced flush in a rat model involves PGD2 and 5-HT, and the effect of certain flavonoids.

Experimental approach: Three skin temperature measurements from each ear were recorded with an infrared pyrometer for each time point immediately before i.p. injection with either niacin or a flavonoid. The temperature was then measured every 10min for 60min.

Key results: Niacin (7.5mg per rat, equivalent to a human dose of 1750mg per 80kg) maximally increased ear temperature to 1.9±0.2 oC at 45min. Quercetin and luteolin (4.3mg per rat; 1000 mg per human), administered i.p. 45min prior to niacin, inhibited the niacin effect by 96 and 88%, respectively. Aspirin (1.22mg per rat; 325mg per human) inhibited the niacin effect by only 30%. Niacin almost doubled plasma PGD2 and 5-HT, but aspirin reduced only PGD2 by 86%. In contrast, luteolin inhibited both plasma PGD2 and 5-HT levels by 100 and 67%, respectively.

Conclusions: Niacin-induced skin temperature increase is associated with PGD2 and 5-HT elevations in rats; luteolin may be a better inhibitor of niacin-induced flush because it blocks the rise in both mediators.  Luteolin inhibited PGD2 100%.

The ‘bald’ phenotype (androgenetic alopecia ) is caused by the high glycaemic, high cholesterol and low mineral ‘western diet’

Conclusion: Taking all of this into consideration, treatment options for androgenetic alopecia should include a low cholesterol and low glycaemic index diet, improved glucose control, and fortification with magnesium. Furthermore, the current narrative does not endorse severe caloric restriction for obvious health reasons.

Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond?

Widespread expression of the transcription factor, nuclear factor (erythroid-derived 2)-like 2 (NRF2 ), which maintains redox homeostasis, has recently been identified in the hair follicle (HF). Small molecule activators of NRF2 may therefore be useful in the management of HF pathologies associated with redox imbalance, ranging from HF greying and HF ageing via androgenetic alopecia and alopecia areata to chemotherapy-induced hair loss. Indeed, NRF2 activation has been shown to prevent peroxide-induced hair growth inhibition.

Multiple parameters can increase the levels of reactive oxygen species in the HF, for example melanogenesis, depilation-induced trauma, neurogenic and autoimmune inflammation, toxic drugs, environmental stressors such as UV irradiation, genetic defects and aging-associated mitochondrial dysfunction. In this review, the potential mechanisms whereby NRF2 activation could prove beneficial in treatment of redox-associated HF disorders are therefore discussed.

– Activation of the transcription factor Nrf2 plays a crucial role in protecting human organ function, specifically scalp hair follicles, against oxidative stress-induced damage.
– Nrf2 activation in human hair follicles leads to the upregulation of genes involved in phase II metabolism, reactive oxygen species clearance, the pentose phosphate pathway, and glutathione homeostasis.
– Knockdown of Nrf2 in cultured human hair follicles confirms the regulation of key Nrf2 target genes and the reduction in reactive oxygen species levels and lipid peroxidation.
– Nrf2 activation significantly reduces premature catagen (hair growth termination) and hair growth inhibition induced by oxidative stress.
– Nrf2 activation protects against oxidative stress-induced apoptosis and reduction in hair matrix proliferation in human hair follicles.
– Oxidative stress plays a significant role in hair follicle damage and graying.
– Chemotherapy can cause hair loss by inducing hair follicle dystrophy.
– Thyroid hormones and melatonin have a direct impact on hair follicle functions.

Lactoferrin promotes hair growth in mice and increases dermal papilla cell proliferation through Erk/Akt and Wnt signaling pathways

Hair loss affects men and women of all ages. Dermal papilla (DP) plays a crucial role in regulating the growth and cycling of hair follicles. Lactoferrin (LF) exhibits a wide range of biological functions, including antimicrobial activity and growth regulation. However, its effect on DP and its role in hair growth remain unknown. In this study, we found that bovine LF (bLF) promoted the proliferation of DP cells and enhanced the phosphorylation of Erk and Akt.

The bLF-mediated proliferation was significantly blocked by the Erk phosphorylation inhibitor PD98059 or the Akt phosphorylation inhibitor LY294002. Moreover, biotin-labeled bLF could bind to DP cells, and the binding was independent of lipoprotein receptor-related protein 1, a known LF receptor. Importantly, bLF stimulated hair growth in both young and aged mice. Moreover, we also found that bLF significantly induced the expression of Wnt signaling-related proteins, including Wnt3a, Wnt7a, Lef1, and β-catenin.

The bLF-mediated DP cell proliferation could be significantly reversed by the Wnt pathway inhibitor XAV939. Our findings suggest that bLF promotes hair growth in mice and stimulates proliferation of DP cells through Erk/Akt and Wnt signaling pathways. This study highlights a great potential of the use of bLF in developing drugs to treat hair loss.

💥Exercise increases insulin sensitivity (60 min cardio daily)

Any exercise that lasts longer than 60 minutes is believed to inhibit the progression of androgenic alopecia When performed routinely and consistently, the blood testosterone level will peak, then decrease in response to the body’s requirements. In addition, an extended duration of exercise will accelerate blood circulation in the scalp, increasing oxygen intake to the scalp.

This can ultimately enhance hair loss, local ischemia of hair follicles, and hypoxic conditions and prevent hair follicle atrophy.To prevent and slow the progression of alopecia, patients with normal cardiopulmonary function can be advised to engage in exercise lasting longer than 60 minutes.

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