Senescent Cells, Sasp & Senolytics

Senescent cells are like retired workers in our bodies. They’ve stopped dividing due to stress or damage, which prevents uncontrolled growth and potential cancer. However, these cells don’t disappear. They unleash a mix of signaling molecules called the Senescence-Associated Secretory Phenotype (SASP). While SASP can be helpful in wound healing,chronic SASP from accumulated senescent cells with age is linked to inflammation and age-related diseases.

This is where senolytics come in. These are drugs being developed to selectively target and eliminate senescent cells. By clearing these “troublemakers,” senolytics have the potential to improve healthspan and potentially lifespan by reducing chronic inflammation and delaying the onset of age-related diseases. Research in this area is ongoing, but the potential to combat aging and promote healthy longevity through senescent cell management is a promising avenue in human health.

Human adipocytes show a lower sensitivity to CD95-induced apoptosisthan preadipocytes.

The anti-apoptotic molecule Bcl-2 is up-regulated during adipogenic differentiation.

Overexpression of Bcl-2 rescues human preadipocytes from CD95-induced apoptosis.

Knockdown of Bcl-2 sensitizes human adipocytes to CD95-induced apoptosis.

Bcl-2 may constitute a new therapeutic target in the treatment of obesity.

• Targeting apoptotic pathways in adipocytes has been suggested as a pharmacological approach to treat obesity. However, adipocyte apoptosis was identified as a cause for macrophage infiltration into adipose tissue. Previous studies suggest that mature adipocytes are less sensitive to apoptotic stimuli as compared to preadipocytes. Here, we aimed to identify proteins mediating apoptosis resistance in adipocytes.Our data revealed that the anti-apoptotic protein Bcl-2 (B-cell lymphoma 2) is up-regulated during adipogenic differentiation. Bcl-2 overexpression in preadipocytes lowers their apoptosis sensitivity to the level of mature adipocytes. Vice versa Bcl-2 knockdown in adipocytes sensitizes these cells to CD95-induced apoptosis. Taken together, our findings suggest a shift in the balance of pro-apoptotic and anti-apoptotic molecules during adipogenesis resulting in a higher apoptosis resistance. This study sheds new light on the apoptotic process in human fat cells and may constitute a new possible target for the specific regulation of adipose tissue mass.
• New dimension in therapeutic targeting of BCL-2 family proteins
• BCL2 FAMILY FUNCTIONS:

• Inhibits Apoptosis:BCL-2, BCL-XL, BCL-W, BCL-B BFL-1 (BH4 BH3 BH1 BH2)

• Promotes Apoptosis:BAX, BAK, BOK (BH3 BH1 BH2) / BID, BAD, BIM, PUMA, NOXA (BH3)
• Bad and Noxa are poor inducers of apoptosis individually because each binds only a subset of the prosurvival proteins, whereas Bim is a potent killer because it binds all of them.
• BID, BIM, and PUMA Are Essential for Activation of the BAX– and BAK-Dependent Cell Death Program
• Senescent cells normally accumulate at a rate of 0.5% or less per month as a function of total cell number in the tissues examined. Caloric restriction resulted in a 3.3 to 6.5% decrease.
• BH4 domain deletion or mutation eliminates the prosurvival activity of Bcl-2
• BH4 domain inhibits apoptosis

• Beyond a classical role in inhibiting apoptosis, BH4 domain has been characterized as a crucial regulator of other important cellular functions attributed to Bcl-2 and Bcl-xL, including proliferation, autophagy, differentiation, DNA repair, cell migration, tumor progression and angiogenesis.
• p21 p27 activation is senolytic
• The role of the cyclin-dependent kinase inhibitor p21 in apoptosis.
• Treatment with a senolytic agent reduced IL17 expression and fibrosis
• BAD BH3 binds BCL-2, BCL-X_L, and BCL-w a/ NOXA BH3 targets MCL-1 and BFL-1/A
• BH3 mimetic acts as a senolytic to remove senscent cells
• BNIP3 is a mitochondrial BH3-only protein that contributes to cell death through activation of the mitochondrial pathway of apoptosis
• Bcl-rambo, a Novel Bcl-2 Homologue That Induces Apoptosis via Its Unique C-terminal Extension

The Bcl-2 family of proteins plays a central regulatory role in apoptosis. We have identified a novel, widely expressed Bcl-2 member which we have named Bcl-rambo. Bcl-rambo shows overall structural homology to the anti-apoptotic Bcl-2 members containing conserved Bcl-2 homology (BH) motifs 1, 2, 3, and 4. Unlike Bcl-2, however, the C-terminal membrane anchor region is preceded by a unique 250 amino acid insertion containing two tandem repeats. No interaction of Bcl-rambo with either anti-apoptotic (Bcl-2, Bcl-x_L, Bcl-w, A1, MCL-1, E1B-19K, and BHRF1) or pro-apoptotic (Bax, Bak, Bik, Bid, Bim, and Bad) members of the Bcl-2 family was observed. In mammalian cells, Bcl-rambo was localized to mitochondria, and its overexpression induces apoptosis that is specifically blocked by the caspase inhibitors, IAPs, whereas inhibitors controlling upstream events of either the ‘death receptor’ (FLIP, FADD-DN) or the ‘mitochondrial’ pro-apoptotic pathway (Bcl-x_L) had no effect. Surprisingly, the Bcl-rambo cell death activity was induced by its membrane-anchored C-terminal domain and not by the Bcl-2 homology region. Thus, Bcl-rambo constitutes a novel type of pro-apoptotic Bcl-2 member that triggers cell death independently of its BH motifs.

Senescent Cell Anti-Apoptotic Pathways (SCAPs)

To remove senescent cells pharmacologically from non-genetically modified individuals, “senolytic” agents, including small molecules, peptides, and antibodies, are being developed21. Since the article describing the first senolytic agents was published in March, 201522, progress in identifying additional senolytic agents and their effects has been remarkably rapid. In that first article, a hypothesis-driven senolytic agent discovery paradigm was implemented. Senescent cells are resistant to apoptosis, despite the SASP factors they release, which should trigger apoptosis. Indeed, pro-apoptotic pathways are up-regulated in senescent cells22, yet these cells resist apoptosis23. The hypothesis was therefore tested that senescent cells depend on pro-survival pathways to defend against their own pro-apoptotic SASP. Using bioinformatics approaches based on the RNA and protein expression profiles of senescent cells, five Senescent-Cell Anti-Apoptotic Pathways (SCAPs) were identified (Table 1). That SCAPs are indeed required for senescent cell viability was verified by RNA interference studies, in which key proteins in these pathways were reduced. Through this approach, survival proteins were identified as the “Achilles’ heels” of senescent cells. Knocking-down expression of these proteins causes death of senescent but not non-senescent cells. Since the discovery of the first five SCAPs, another was identified (Table 1)24. This approach and the SCAPs discovered were subsequently used by others and us to identify putative senolytic targets22, 24, 25, 26, 27.

The SCAPs required for senescent cell resistance to apoptosis vary among cell types.The Achilles’ heels, for example of senescent human primary adipose progenitors differ from those in a senescent human endothelial cell strain, implying that agents targeting a single SCAP may not eliminate all types of senescent cells. So far, the senolytics that have been tested across a wide range of senescent cell types have all exhibited a degree of cell type specificity. For example, navitoclax is senolytic in a cell culture-acclimated human umbilical vein endothelial cell strain, but is not very effective against senescent primary human fat cell progenitors27. Even within a particular cell type, human lung fibroblasts, nativoclax is senolytic in the culture-acclimated IMR-90 lung fibroblast-like cell strain, while it is less so in primary human lung fibroblasts isolated from patients19, 27. Without extensive testing across a range of truly primary cells, as opposed to cell lines or culture-acclimated cell strains, it is difficult to contend that any particular candidate senolytic drug is universally effective for all types of senescent cells. Furthermore, senolytics can act synergistically in some cell types. For example, while neither dasatinib nor quercetin was significantly senolytic in mouse embryonic fibroblasts in vitro, the combination of dasatinib and quercetin was senolytic22. Thus, different senolytics may prove to be optimal for different indications and combinations of senolytics can be used to broaden the range of senescent cell types that are targeted.

YOU WANT TO INHIBIT THESE PATHWAYS TO KILL SENESCENT CELLS:

BCL-2 / BCL-Xl / BCL-W family

. PI3Kδ / AKT / ROS-protective/ metabolic

MDM2 / p53 / p21 / serpine (PAI-1&2)

Ephrins / dependence receptors/ tyrosine kinases

HIF-1α

HSP-90

Markers of senescent cells include:

Increases in cell size, lipofuscin accumulation, high expression of the cell cycle regulator, p16INK4A, p21CIP1, and SASP factors (e.g., IL-6, IL-8, monocyte chemoattractant protein-1, plasminogen-activated inhibitor-1, and many others), increased cellular senescence-associated β-galactosidase (SA-βgal) activity, and appearance of senescent-associated distension of satellites (SADS) and telomere-associated DNA damage foci (TAFs), among others. None of these markers are fully sensitive or specific, so combinations of them are needed to draw conclusions about effects of diseases or interventions on senescent cell numbers.

SASP (THE Senescence-Associated Secretory Phenotype)

INTRODUCTION

Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at risk for malignant transformation. However, accumulating evidence shows that senescent cells can have deleterious effects on the tissue microenvironment. The most significant of these effects is the acquisition of a senescence-associated secretory phenotype (SASP) that turns senescent fibroblasts into proinflammatory cells that have the ability to promote tumor progression.
The tissue microenvironment is defined by the phenotypes of the cells in the immediate area and by the physical and chemical properties of the soluble and insoluble factors surrounding cells within a given tissue. These properties include temperature and oxygen tension, as well as various molecules that may be produced locally—for example, growth factors and cytokines. Further, cells within tissues form a dynamic network that contributes to their microenvironment. At the same time, the tissue microenvironment regulates cell behavior. This reciprocal relationship determines tissue function and repair and is also central to a number of pathologies, including cancer.

A permissive microenvironment supports and promotes tumor growth and cancer cell aggressiveness (1–4). Alterations in the cellular and molecular composition of the connective tissues surrounding carcinomas allow tumors to evade detection by the immune system as well as to proliferate inappropriately, invade the surrounding tissue structure, and eventually metastasize. The synergy between an altered microenvironment and the genetic alterations acquired by tumor cells allows these cells to evade preventive mechanisms and become fully malignant. Cellular senescence is now recognized as a potent tumor-suppressive mechanism that arrests the growth of cells at risk for malignant transformation (5–12). However, recent studies show that senescent cells develop altered secretory activities that may induce changes in the tissue microenvironment, relaxing its control over cell behavior and promoting tumorigenesis (13–18).

How can the senescence response be both tumor suppressive and procarcinogenic? It is important to consider that a biological process such as cellular senescence can be both beneficial and deleterious. The idea that processes can have such dual effects is consistent with a major evolutionary theory of aging termed antagonistic pleiotropy (19). The senescence-associated secretory phenotype (SASP) represents one of the darkest sides of the senescence response and is the focus of this review. We particularly emphasize the potential effects of the SASP (20) on cell behavior in the context of tumor progression.

CELLULAR SENESCENCE

Cellular senescence occurs in culture and in vivo as a response to excessive extracellular or intracellular stress. The senescence program locks the cells into a cell-cycle arrest that prevents the spread of damage to the next cell generation and precludes potential malignant transformation (19). Senescent cells have been shown to accumulate over the life span of rodents, nonhuman primates, and humans (21). These cells are found primarily in renewable tissues and in tissues that experience prolonged inflammation.

A plethora of stresses can provoke cellular senescence (22, 23). These stresses include telomeric dysfunction (telomere uncapping) resulting from repeated cell division (termed replicative senescence), mitochondrial deterioration, oxidative stress, severe or irreparable DNA damage and chromatin disruption (genotoxic stress), and the expression of certain oncogenes (oncogene-induced senescence) (see Figure 1) (24–31). Stresses that cause cellular senescence can be induced by external or internal chemical and physical insults encountered during the course of the life span, during therapeutic interventions (for example, X-irradiation or chemotherapy), or as a consequence of endogenous processes such as oxidative respiration and mitogenic signals. External mitogenic signals, for example growth-related oncogene alpha (GROα) secretion by tumor cells in close proximity to normal cells (32) or circulating angiotensin II (33, 34), have also been shown to induce cellular senescence. All somatic cells that have the ability to divide can undergo senescence. Regardless of the disparate mechanisms of senescence-inducing stresses, the senescence program is activated once a cell has sensed a critical level of damage or dysfunction. So far, the senescence growth arrest has been shown to depend on the activities of the major tumor-suppressor pathways controlled by p16INK4a and pRB (retinoblastoma protein), as well as by p53. Some of the molecules involved in pathways upstream and downstream of the senescence-associated phenotype have been used as markers to detect senescent cells in culture and in vivo.

Figure 1

THE SECRETORY PHENOTYPE OF SENESCENT CELLS

The senescent phenotype is not limited to an arrest of cell proliferation. In fact, a senescent cell is a potentially persisting cell that is metabolically active and has undergone widespread changes in protein expression and secretion, ultimately developing the SASP. This phenotype has also been termed the senescence-messaging secretome (35). We recently provided a large-scale characterization of the SASP, using antibody arrays to quantitatively measure factors secreted by human fibroblasts and epithelial cells (18), as well as mouse fibroblasts (J.P. Coppé & J. Campisi, unpublished data). The potential existence of the SASP was already suggested by large-scale comparative gene (mRNA) expression studies performed on fibroblasts from different-aged donors and different tissues of origin (36–46). Among the cells that have been shown to senesce and secrete biologically active molecules are liver stellate cells (47), endothelial cells (36, 48–51), and epithelial cells of the retinal pigment, mammary gland, colon, lung, pancreas, and prostate (8, 18, 36, 41, 52–56).

Senescence-associated changes in gene expression are specific and mostly conserved within individual cell types. Most differences between the molecular signatures of presenescent and senescent cells entail cell-cycle- and metabolism-related genes, as well as genes encoding the secretory proteins that constitute the SASP. The SASPincludes several families of soluble and insoluble factors (see Table 1). These factors can affect surrounding cells by activating various cell-surface receptors and corresponding signal transduction pathways that may lead to multiple pathologies, including cancer. SASPfactors can be globally divided into the following major categories: soluble signaling factors (interleukins, chemokines, and growth factors), secreted proteases, and secreted insoluble proteins/extracellular matrix (ECM) components. SASP proteases can have three major effects: (a) shedding of membrane-associated proteins, resulting in soluble versions of membrane-bound receptors, (b) cleavage/degradation of signaling molecules, and/or (c) degradation or processing of the ECM. These activities provide potent mechanisms by which senescent cells can modify the tissue microenvironment. In the following sections, we discuss these SASP subsets and some of their known paracrine effects on nearby cells, with an emphasis on their ability to facilitate cancer progression.

Table 1 The senescence-associated secretory phenotype (SASP). Factors significantly altered between presenescent and senescent states are listed.

Soluble Signaling Factors as Major Components of the Senescence-Associated Secretory Phenotype

Senescent cells secrete interleukins, inflammatory cytokines, and growth factors that can affect surrounding cells.

IL-6

The most prominent cytokine of the SASP is interleukin-6 (IL-6), a pleiotropic proinflammatory cytokine(see Figure 2). IL-6 has been shown to be associated with DNA damage– and oncogenic stress–induced senescence of mouse and human keratinocytes, melanocytes, monocytes, fibroblasts, and epithelial cells (16, 18, 57, 58). Further, IL-6 secretion appears to be directly controlled by persistent DNA-damage signaling (ATM and CHK2), independent of the p53 pathway (59). Through IL-6 expression, senescent cells can directly affect neighboring cells that express the IL-6R (gp80) and gp130 signaling complex at their surface, such as epithelial and endothelial cells of various functions and origins.

Figure 2

IL-1

Another interleukin signaling pathway demonstrated to be upregulated by senescent cells is that of IL-1(60, 61). Both IL-1α and -β are overexpressed and secreted by senescent endothelial cells (62), fibroblasts (63, 64), and chemotherapy-induced senescent epithelial cells (53). These cytokines can affect neighboring cells through the cell-surface receptors (IL-1 receptor/Toll-like receptor superfamily), which act primarily to trigger the nuclear factor kappa B and activating protein 1 pathways (65).

Chemokines (CXCL and CCL)

Most senescent cells overexpress IL-8 (CXCL-8) (see Figure 2), along with GROα and GROβ (CXCL-1 and -2; the murine CXCL-1 is named KC) (58, 66, 67). CCL family members that are generally upregulated in senescent cells include MCP-2, -4, and -1 (CCL-8, -13, and -2); HCC-4 (CCL-16); eotaxin-3 (CCL-26); and macrophage inflammatory protein (MIP)-3α and -1α (CCL-20, -3). MCP-3 (CCL-7) is overexpressed by senescent liver stellate cells and by prostate and skin fibroblasts. Fibroblasts induced to senesce by oncogenic RAS secrete high levels of MCP-3 as well as I-309 (CCL-1). In addition, both fibroblasts induced to senesce by RAS and stellate cells induced to senesce by liver damage secrete high levels of another two members of the CXCL family, GCP-2 (CXCL-6) and ENA-78 (CXCL-5). Overexpression of PF-4 (CXCL-4) and SDF-1 (CXCL-12) was observed in senescent prostate fibroblasts (46, 68). Recently, it was shown that cells undergoing oncogene-induced senescence secrete multiple CXCR-2 (IL-8RB)-binding chemokines (15). It was proposed that senescent cells activate a self-amplifying secretory network in which CXCR-2-binding chemokines reinforce growth arrest.

IGF pathway

The insulin-like growth factor (IGF)/IGF receptor network may also contribute to the effect senescent cells exert on their microenvironment. Senescent endothelial, epithelial, and fibroblast cells express high levels of almost all the IGF-binding proteins(IGFBPs), including IGFBP-2, -3, -4, -5, and -6 (18, 69, 70) and their regulators, IGFBP-rP1 and -rP2 [also known as connective tissue growth factor (CTGF)] (44, 71). Recently, activation of the BRAF oncogene in primary fibroblasts was shown to lead to the secretion of IGFBP-7, which acts through autocrine/paracrine pathways to induce senescence and apoptosis in neighboring cells (72).

Other soluble factors

There are additional soluble factors associated with the SASP. For example, inflammatory cytokines such as the colony-stimulating factors (CSFs, including GM-CSF and G-CSF) are secreted at high levels by senescent fibroblasts (18). In addition, osteoprotegerin, a secreted decoy receptor for tumor necrosis factor alpha, is present at high levels in the extracellular milieu of senescent fibroblasts. Other molecules upregulated at senescence include prostaglandin E2 (PGE2) (57, 73) and Cox-2,the enzyme responsible for the production of PGE2 and other prostaglandins.

EFFECTS ON CELL BEHAVIOR

Factors secreted by senescent cells can promote tumor development in vivo and malignant phenotypes such as proliferation and invasiveness in cell-culture models. These effects have been observed in a number of tissues, including breast (13, 18, 77, 78, 114), skin (115), prostate (18, 116), pancreas (117), and oropharyngial mucosa (14). The effects of the complex SASP are, of course, dependent on the tissue context. Thus, different models show different effects of the SASP. In the following sections, we discuss in greater detail the various behavioral changes cells can undergo when residing in the proximity of senescent cells and how the senescent tissue microenvironment can facilitate tumor initiation and progression.

“Social Life” of Senescent Cells: What Is SASP and Why Study It?

Cellular senescence was first described as a failure of normal human cells to divide indefinitely in culture. Until recently, the emphasis in the study of cell senescence has been focused on the accompanying intracellular processes. The focus of the attention has been on the irreversible growth arrest and two important physiological functions that rely on it: suppression of carcinogenesis due to the proliferation loss of damaged cells, and the acceleration of organism aging due to the deterioration of the tissue repair mechanism with age.

However, the advances of the past years have revealed that senescent cells can impact the surrounding tissue microenvironment, and, thus, that the main consequences of senescence are not solely mediated by intracellular alterations. Recent studies have provided evidence that a pool of molecules secreted by senescent cells, including cytokines, chemokines, proteases and growth factors, termed the senescence-associated secretory phenotype (SASP), via autocrine/paracrine pathways can affect neighboring cells. Today it is clear that SASPfunctionally links cell senescence to various biological processes, such as tissue regeneration and remodeling, embryonic development, inflammation, and tumorigenesis. The present article aims to describe the “social” life of senescent cells: basically, SASPconstitution, molecular mechanisms of its regulation, and its functional role.

It is well known that the main features of CS are similar across its different forms and different types of proliferating cells [40]. Figure 2 shows the most important “individual” intracellular changes that accompany CS, which are subdivided into events occurring in the nucleus and in the cytoplasm. The change in the secretory profile occupies a special place among the modifications accompanying CS. It is generally accepted that the senescence– associated secretory phenotype (SASP) defines the engagement of senescent cells in a wide range of processes, such as reparation, propagation of senescence, immune clearance, embryogenesis, and tumorigenesis [29, 31, 38, 79, 80].

Classification of SASP factors

The term SASP was first used in 2008 to refer to the factors secreted by senescent cells [24]. The following classification of SASP components has been adopted: soluble signaling factors, proteases, insoluble extracellular matrix proteins, and non-protein components [78]. SASP factors can be divided into the following groups based on molecular mechanisms [81]:

1) Factors binding to a receptor. This group includes soluble signaling molecules, such as cytokines, chemokines, and growth factors. These factors can influence cells of the microenvironment by interacting with the corresponding surface receptors on their membranes and, thus, triggering various intracellular signaling cascades [82, 83]. The most well known representatives of this group are interleukins IL-6, IL-8, IL-1a, chemokines GROα, GROβ, CCL-2, CCL-5, CCL-16, CCL-26, CCL-20, and the growth factors HGF, FGF, TGFβ, and GM-CSF.

2) Factors acting directly. This group includes matrix metalloproteases MMP-1, MMP-10, MMP-3 and serine proteases: the tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA). These factors are capable of cleaving membrane-bound proteins, destroying signaling molecules and remodeling the extracellular matrix, to enable senescent cells to modify their microenvironment [84]. Small non-protein components, such as reactive oxygen (ROS) and nitrogen species that damage neighboring cells, can also be included in this group [78, 85].

3) Regulatory factors. This group includes tissue inhibitors of metalloproteases (TIMP), the plasminogen activator inhibitor (PAI), and insulin-like growth factor binding proteins (IGFBP). These factors do not have their own enzymatic activity. However, when they bind to factors from the first and second groups, they regulate their functioning. For example, TIMP inhibits the activity of most MMPs [86], PAI-1 functions primarily as an inhibitor of tPA and uPA [87], and IGFBP function as IGF transport proteins [88].

In addition to all the factors mentioned above, which are secreted by senescent cells, another component has recently begun to be viewed as part of SASP: extracellular vesicles, in particular vesicles associated with microRNAs [89]. It turns out that such vesicles can affect neighboring cells and cells located at a considerable distance, both by initiating and suppressing CS, depending on the composition of microRNAs.

It should be emphasized that the specific qualitative and quantitative composition of the secreted factors largely depends on the type of cells and the inducer of senescence, which makes it very difficult to study this CS feature. Several approaches to the study of SASP and elucidation of the functions of its individual components have been described to date. The main approaches are presented at Fig. 3.

Fig. 3

Experimental approaches to study SASP and to identify the functional role of its individual components

Mechanisms of SASP regulation

It is well known that cellular senescence is not a onetime phenomenon, but one that develops over time [99]. Remarkably, SASP has also recently begun to be viewed as a dynamic process which can be subdivided into several phases [16]. It is believed that the first phase of secretion begins immediately after DNA damage and lasts for the first 36 hours. It should be noted that the onset of this phase is not sufficient evidence in favor of initiation of senescence, since it does not preclude complete repair or apoptosis [99]. The next phase is the “early” SASP phase, which continues for several days after the initiation of CS. It is during this period that the most important SASP factors, for example IL-1α, start to appear. During the next 4–10 days, the secretion of most factors intensifies due to the autocrine effect of SASP, which ultimately leads to the formation of “mature” SASP [16]. Such a wave-like secretion of factors during the development of CS is largely attributed to positive feedback loops and complex regulatory mechanisms. The most common mechanisms for SASP regulation are presented below.

It should be noted that SASP is regulated both at the transcriptional and post-transcriptional levels. The key role in the regulation of SASP components expression, including IL-6, IL-8, CXCL1, and CXCR2, belongs to the nuclear factor kappa-light-chain-enhancer of activated B cells, NF-kB [100–102]. For most of these factors, control over transcription is achieved through positive feedback loops. A vivid example of such “self-amplifying” loops is the regulation of IL-1α secretion [15, 103]. It has been reported that another transcription factor, C/EBPβ, is also involved: by binding directly to the promoter of the IL-6 gene, where it initiates its expression [82, 104].

At the post-transcriptional level of SASP regulation, it is customary to identify DDR (DNA Damage Response)-dependent and independent mechanisms [15]. As mentioned above, one of the most important features of CS is the DNA damage response. It has been shown that knockdowns of such DDR components as ATM, Chk2, NBS1, and H2AX reduce the expression and, accordingly, the secretion of a number of SASP factors, including IL-6 and IL-8 [104–106]. Despite evidence that DDR is involved in SASP regulation, the detailed mechanisms for their relationships are not fully understood. The signaling pathways known today are associated with the ability of DDR components, in particular ATM kinase, to somehow regulate NFkB activity. For example, ATM can form complexes with the NEMO protein, which, due to the initiation of DDR, are exported from the nucleus to the cytoplasm, where NEMO binds to and activates IKK kinase. IKK promotes the dissociation of the inhibitory IkB protein from its complex with NF-kB and activation of the latter [107].

More recently, the involvement of the transcription factor GATA4 in the DDR-dependent mechanism of SASPregulation has been demonstrated [108]. Normally, GATA4 is degraded by p62-mediated autophagy. However, autophagy is suppressed in most senescent cells, and, therefore, GATA4 stabilizes, and this process is ATM-dependent. The accumulation of GATA4 in senescent cells facilitates the initiation and maintenance of NF-kB activity.

List of markers/methods for senescent cell detection: Marker/Method

Large and flat morphology (Various microscopical and staining approaches)

Lack of cell proliferation markers: absence of Ki-67, BrdU/EdU-incorporation, no colony formation

Lack of response to growth signals

Resistance to apoptosis: BCL family members ( Bcl-2, Bcl-w, or Bcl-xL)

p53

ARF

CDKIs (p16INK4a, p15INK4B, p21WAF/CIP1, p27KIP1)

DDR markers (ATM, 53BP1, γH2AX, MBS1, CHK2)

Lamin B1 reduction

DEC1 (BHLHE40)

DCR2 (TNFRSF10D)

PML nuclear bodies

SAHF (senescence-associated heterochromatic foci)/markers (HP1-γ, H3K9me3)

HMGA proteins

TIF (telomere dysfunction-induced foci)

TAF (telomere-associated foci)

DNA-SCARS (DNA segments with chromatin alterations reinforcing senescence)

Cell surface proteins (DEP1, B2MG and DPP4)

SA-β-gal (senescence-associated β-galactosidase activity)

Modifications: chromogenic or fluorescent (one or two-photon fluorescence excitation) probes for the visualization of SA-β-gal activity

Lipofuscin accumulation – Hybrid histochemical/immunohistochemical method

SASP factors, ligands and receptors (IL-1a, IL-6,and IL-8, CCL2 and metalloproteinases)

Quantitative identification based on a combination of SA-β-gal and molecular marker staining with flow cytometry and high content image analysis

Senescence chips for ultrahigh-throughput isolation and removal of senescent cells

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SCIENTIFIC STUDIES:

1. The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
2. The Clinical Potential of senolytic Drugs
3. Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
4. Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors
5. Clinical strategies and animal models for developing senolytic agents
6. senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo
7. Discovery of piperlongumine as a potential novel lead for the development of senolytic agents
8. Pleiotropic Effects of Tocotrienols and Quercetin on Cellular senescence: Introducing the Perspective of senolytic Effects of Phytochemicals
9. A Novel Indication for Panobinostat as a senolytic Drug in NSCLC and HNSCC
10. Oxidation resistance 1 is a novel senolytic target
11. Effects of senolytic drugs on human mesenchymal stromal cells
12. senolytic activity of piperlongumine analogues: Synthesis and biological evaluation
13. Hsp90 inhibitors as senolytic drugs to extend healthy aging
14. The curcumin analog EF24 is a novel senolytic agent
15. senolytic drugs in respiratory medicine: is it an appropriate therapeutic approach?
16. senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model
17. Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts
18. Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin
19. senolytic Cocktail Dasatinib+Quercetin (D+Q) Does Not Enhance the Efficacy of senescence-Inducing Chemotherapy in Liver Cancer
20. Emerging senolytic agents derived from natural products
21. senolytic treatments applied to osteoarthritis: a step towards the end of orthopedic surgery?
22. Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy
23. Curcumin and o-Vanillin Exhibit Evidence of senolytic Activity in Human IVD Cells In Vitro
24. senolytic helpers
25. senolytic therapies for healthy longevity
26. Removing Aging Cells With a New Class of senolytic Drug
27. Quercetin in Idiopathic Pulmonary Fibrosis: Another Brick in the senolytic Wall
28. SAT0053 Identification of novel drugs with senolytic activity as osteoarthritis therapeutics
29. Abstract 11299: A Novel senolytic Drug for Aging and Age-Related Cardiometabolic Disorders
30. Novel Classification Perspective of Geroprotective and senolytic Drugs as an Antiaging Strategy
31. LSC – 2017 – senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo
32. senolytic treatment targets aberrant p21-expression to restore liver regeneration in adult mice
33. Augmented Inflammatory Responses in Aging are Driven by Circulating mtDNA and Ameliorated by senolytic Treatment
34. senescence Signature in Skin Biopsies From Systemic Sclerosis Patients Treated With senolytic Therapy: Potential Predictor of Clinical Response?
35. Fenofibrate, a peroxisome proliferator-activated receptor alpha, is a novel molecule with senolytic and autophagy activity for cartilage degeneration and osteoarthritis
36. senolytic activity of small molecular polyphenols from olive restores chondrocyte redifferentiation and cartilage regeneration in osteoarthritis
37. Treatment of parkinson’s disease and other conditions caused or mediated by senescent astrocytes using small molecule senolytic agents
38. Application of ex-vivo spheroid model system for the analysis of senescence and senolytic phenotypes in uterine leiomyoma
39. AMPK-mediated senolytic and senostatic activity of quercetin surface functionalized Fe3O4 nanoparticles during oxidant-induced senescence in human fibroblasts
40. Mitochondrial DNA-Mediated Inflammatory Injury in Old Donors Is Improved by senolytic Treatment
41. The biology of senescence.
42. Leaf senescence
43. Cellular senescence in Aging Primates
44. senescence in premalignant tumours
45. senescence mechanisms
46. Cancer, aging and cellular senescence.
47. The essence of senescence
48. Four faces of cellular senescence
49. Microarray analysis of replicative senescence
50. Aging, Cellular senescence, and Cancer
51. Molecular aspects of leaf senescence
52. Cellular senescence in Cancer and Aging
53. Making Sense of senescence (Molecular Genetic Regulation and Manipulation of Leaf senescence).
54. Pleiotropy, Natural Selection, and the Evolution of senescence
55. Cellular senescence as a tumor-suppressor mechanism
56. Ageing. The biology of senescence.
57. CHLOROPHYLL DEGRADATION DURING senescence*
58. The moulding of senescence by natural selection
59. The molecular biology of leaf senescence
60. Gene expression during leaf senescence
61. A new murine model of accelerated senescence
62. The biology of replicative senescence
63. The senescence of leaves.
64. A DNA damage checkpoint response in telomere-initiated senescence
65. Cellular senescence: from physiology to pathology
66. Putting the stress on senescence
67. Rapamycin decelerates cellular senescence
68. Inhibition of Leaf senescence by Autoregulated Production of Cytokinin
69. senescence and Postharvest Physiology
70. Free radicals and senescence
71. Cellular senescence: when bad things happen to good cells
72. Bmi1, stem cells, and senescence regulation
73. The signals and pathways activating cellular senescence
74. senescence-accelerated mouse (SAM): A novel murine model of senescence
75. Testosterone Secretion and Metabolism in Male senescence
76. senescence in Plant Development
77. Catalase, Peroxidase, and Polyphenoloxidase Activities during Rice Leaf senescence
78. Replicative senescence: An Old Lives’ Tale?
79. Transcriptome of Arabidopsis leaf senescence
80. Nitrogen metabolism and remobilization during senescence
81. Tumor Cell senescence in Cancer Treatment
82. senescence Induced by Altered Telomere State, Not Telomere Loss
83. senescence of Activated Stellate Cells Limits Liver Fibrosis
84. Telomeres, telomerase and senescence
85. LABORATORY EVOLUTION OF POSTPONED senescence IN DROSOPHILA MELANOGASTER
86. Defining senescence and death
87. Chemokine Signaling via the CXCR2 Receptor Reinforces senescence
88. FUNGAL senescence
89. Telomeres, stem cells, senescence, and cancer
90. Replicative senescence: the human fibroblast comes of age
91. Evolution of senescence: late survival sacrificed for reproduction
92. Cellular senescence
93. SELECTION FOR DELAYED senescence IN DROSOPHILA MELANOGASTER
94. senescence in tumours: evidence from mice and humans
95. Fat tissue, aging, and cellular senescence
96. Inflammatory networks during cellular senescence: causes and consequences
97. senescence
98. Role of Ceramide in Cellular senescence
99. senescence of human fibroblasts induced by oncogenic Raf
100. Ethylene and flower senescence
101. Cell senescence and cancer
102. Therapy-Induced senescence in Cancer
103. Genes involved in senescence and immortalization
104. BRAFE600-associated senescence-like cell cycle arrest of human naevi
105. Vascular Cell senescence
106. Reversible inhibition of tomato fruit senescence by antisense RNA
107. A senescent cell bystander effect: senescence‐induced senescence
108. Molecular regulation of leaf senescence
109. senescence in a Bacterium with Asymmetric Division
110. senescence-messaging secretome: SMS-ing cellular stress
111. Leaf senescence
112. senescence, Apoptosis or Autophagy?
113. senescence and immortalization: role of telomeres and telomerase
114. senescence‐Accelerated Mouse (SAM): A Novel Murine Model of Accelerated senescence
115. Regulation of cellular senescence by p53
116. If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells
117. Formation of MacroH2A-Containing senescence-Associated Heterochromatin Foci and senescence Driven by ASF1a and HIRA
118. Oncogene-induced senescence as an initial barrier in lymphoma development
119. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
120. Tumor suppressors and oncogenes in cellular senescence
121. senescence in human intervertebral discs
122. Oncogene-Induced senescence Relayed by an Interleukin-Dependent Inflammatory Network
123. Cellular senescence and its effector programs
124. 15 – Whole Plant senescence
125. Cellular senescence and organismal aging
126. senescence-Associated Gene Expression during Ozone-Induced Leaf senescence in Arabidopsis
127. Human senescence
128. senescence impairs successful reprogramming to pluripotent stem cells
129. Oncogenic ras Provokes Premature Cell senescence Associated with Accumulation of p53 and p16INK4a
130. Programmed Cell senescence during Mammalian Embryonic Development
131. Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
132. The case for negative senescence
133. Methods to Detect Biomarkers of Cellular senescence
134. senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
135. senescence‐associated β‐galactosidase is lysosomal β‐galactosidase
136. Akt Determines Replicative senescence and Oxidative or Oncogenic Premature senescence and Sensitizes Cells to Oxidative Apoptosis
137. Deferral of Leaf senescence with Calcium
138. Experimental Modification of Plant senescence.
139. The Activated Oxygen Role of Peroxisomes in senescence
140. Aging, articular cartilage chondrocyte senescence and osteoarthritis
141. PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
142. Pro-senescence therapy for cancer treatment
143. senescence comes of age
144. The senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
145. Oxidative DNA damage and senescence of human diploid fibroblast cells
146. senescence surveillance of pre-malignant hepatocytes limits liver cancer development
147. Extreme heat effects on wheat senescence in India
148. Cellular senescence: putting the paradoxes in perspective
149. Cellular senescence and cancer treatment
150. Calcium in plant senescence and fruit ripening
151. An alternative pathway for yeast telomere maintenance rescues est1− senescence
152. THE TWO-STAGE MECHANISM CONTROLLING CELLULAR senescence AND IMMORTALIZATION
153. Ethylene, Plant senescence and Abscission
154. The molecular genetic analysis of leaf senescence
155. Hallmarks of senescence in carcinogenesis and cancer therapy
156. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
157. Homocysteine accelerates endothelial cell senescence
158. The molecular analysis of leaf senescence – a genomics approach
159. A Cellular Timetable of Autumn senescence
160. MicroRNA-34a regulation of endothelial senescence
161. Involvement of Hydrogen Peroxide in the Regulation of senescence in Pear
162. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
163. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
164. Deconstructing PML-induced premature senescence
165. Mortality Patterns Suggest Lack of senescence in Hydra
166. Plant senescence processes and free radicals
167. Role of oxidative carbonylation in protein quality control and senescence
168. Measuring Wheat senescence with a Digital Camera
169. Brain acetylcholine synthesis declines with senescence
170. Human cell senescence as a DNA damage response
171. Molecular genetics of leaf senescence in Arabidopsis
172. Development and senescence of the Postnatal Bovine Ovary
173. Leaf senescence in Brassica napus: cloning of senescence related genes by subtractive hybridisation
174. Alveolar Cell senescence in Patients with Pulmonary Emphysema
175. Functional senescence in Drosophila melanogaster
176. Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity
177. The evolutionary ecology of senescence
178. Replicative senescence: Implications for in Vivo Aging and Tumor Suppression
179. SASP reflects senescence
180. Ethylene regulates the timing of leaf senescence in Arabidopsis
181. Cellular senescence, cancer and aging: the telomere connection
182. Control of Jasmonate Biosynthesis and senescence by miR319 Targets
183. Replicative senescence of Mesenchymal Stem Cells: A Continuous and Organized Process
184. T-helper-1-cell cytokines drive cancer into senescence
185. Cellular senescence and tumor suppressor gene p16
186. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
187. Telomeres and senescence: Ending the Debate
188. Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular senescence
189. The aging brain: morphomolecular senescence of cortical circuits
190. Reversal of human cellular senescence: roles of the p53 and p16 pathways
191. Molecular analysis of natural leaf senescence in Arabidopsis thaliana
192. A transcriptional timetable of autumn senescence
193. Cellular senescence and cancer
194. Human SIR2 deacetylates p53 and antagonizes PML/p53‐induced cellular senescence
195. Telomere dysfunction and tumour suppression: the senescence connection
196. Many roads lead to oncogene-induced senescence
197. A negative feedback signaling network underlies oncogene-induced senescence
198. The anemia of senescence
199. Plant senescence and crop productivity
200. Replicative senescence: a critical review
201. senescence in Health and Disease
202. A NAC Gene Regulating senescence Improves Grain Protein, Zinc, and Iron Content in Wheat
203. Last exit: senescence, abscission, and meristem arrest in Arabidopsis.
204. Memory loss in senescence.
205. Cigarette Smoke Induces Cellular senescence
206. Rethinking Chronic Allograft Nephropathy
     The Concept of Accelerated senescence
207. The sound of senescence
208. Oncogenic Braf Induces Melanocyte senescence and Melanoma in Mice
209. What has senescence got to do with cancer?
210. Targets of AtWRKY6 regulation during plant senescence and pathogen defense
211. Telomerase, senescence and ageing
212. Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat.
213. PML is induced by oncogenic ras and promotes premature senescence
214. The senescence-Induced Staygreen Protein Regulates Chlorophyll Degradation
215. Bypass of senescence After Disruption of p21CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts
216. Differential expression of senescence-associated mRNAs during leaf senescence induced by different senescence-inducing factors in Arabidopsis
217. Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts.
218. An attempt to prevent senescence: A mitochondrial approach
219. Delayed leaf senescence induces extreme drought tolerance in a flowering plant
220. senescence and Rejuvenation
221. Forging a signature of in vivo senescence
222. Evolutionary and Nonevolutionary Theories of senescence
223. Cellular senescence revisited: a review
224. Living on a break: cellular senescence as a DNA-damage response
225. senescence in the whole plant.
226. Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for senescence?
227. Geriatric muscle stem cells switch reversible quiescence into senescence
228. Physiology and molecular biology of petal senescence
229. Endothelial Cell senescence in Human Atherosclerosis
230. Telomere positional effects and the regulation of cellular senescence
231. Role of Ethylene in senescence of Petals—Morphological and Taxonomical Relationships
232. Paradoxical suppression of cellular senescence by p53
233. Evidence Supporting a Role of Jasmonic Acid in Arabidopsis Leaf senescence
234. Prohibitin: Potential role in senescence, development, and tumor suppression
235. senescence and aging: the critical roles of p53
236. senescence as a mode of tumor suppression.
237. Large‐scale identification of leaf senescence‐associated genes
238. NK and NK/T cells in human senescence
239. Vascular endothelial senescence: from mechanisms to pathophysiology
240. Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence.
241. When cells get stressed: an integrative view of cellular senescence
242. A mutant with a defect in telomere elongation leads to senescence in yeast
243. Selenium – an antioxidative protectant in soybean during senescence
244. Oncogene-Induced senescence: Putting the Brakes on Tumor Development
245. The power and the promise of oncogene-induced senescence markers
246. The role of chondrocyte senescence in osteoarthritis
247. OSTEOPOROSIS : DISEASE OR senescence ?
248. The pathobiology of Parkinson’s disease: biochemical aspects of dopamine neuron senescence.
249. A complex secretory program orchestrated by the inflammasome controls paracrine senescence
250. Growth, Maturation, and senescence in Fruits
251. ORE9, an F-Box Protein That Regulates Leaf senescence in Arabidopsis
252. Cell senescence and hypermitogenic arrest
253. Cellular senescence mediates fibrotic pulmonary disease
254. Accelerated immune senescence and HIV-1 infection
255. senescence of leafy vegetables
256. Mitotic and postmitotic senescence in plants.
257. NaCl-induced senescence in Leaves of Rice (Oryza sativaL.) Cultivars Differing in Salinity Resistance
258. Erosion of the telomeric single-strand overhang at replicative senescence
259. Mechanisms of cellular senescence in human and mouse cells
260. Loss of ‘Complexity’ and AgingPotential Applications of Fractals and Chaos Theory to senescence
261. Id proteins in cell cycle control and cellular senescence
262. A role for both RB and p53 in the regulation of human cellular senescence
263. Physiological significance of anthocyanins during autumnal leaf senescence
264. Lamin B1 loss is a senescence-associated biomarker
265. Isolation and Identification of a senescence-promoting Substance from Wormwood (Artemisia absinthium L.)
266. Oxidative stress and antioxidant activity as the basis of senescence in maize leaves
267. Nutrients mobilized from leaves of Arabidopsis thaliana during leaf senescence
268. Ethylene in Plant Growth, Development, and senescence
269. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes
270. Ras Proteins Induce senescence by Altering the Intracellular Levels of Reactive Oxygen Species
271. Flower senescence in daylily (Hemerocallis)
272. Role of Oxidative Stress in Telomere Length Regulation and Replicative senescence
273. Leaf senescence: Correlated with Increased Levels of Membrane Permeability and Lipid Peroxidation, and Decreased Levels of Superoxide Dismutase and Catalase
274. Deletion of Ku86 causes early onset of senescence in mice
275. senescence, apoptosis and therapy — cutting the lifelines of cancer
276. Cellular senescence: A Translational Perspective
277. senescence-accelerated mouse (SAM): a biogerontological resource in aging research
278. The timing of maize leaf senescence and characterisation of senescence‐related cDNAs
279. Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence
280. Human melanocyte senescence and melanoma susceptibility genes
281. UV-C treatment delays postharvest senescence in broccoli florets
282. Processes and control of plant senescence.
283. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
284. Pollination-induced flower senescence: a review
285. Structure elucidation of a senescence cross-link from human extracellular matrix. Implication of pentoses in the aging process.
286. Oncogene-Induced Cell senescence — Halting on the Road to Cancer
287. Mitochondrial Dysfunction Contributes to Oncogene-Induced senescence
288. Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence
289. Cell cycle arrest is not senescence
290. Proteolytic activity during senescence of plants
291. senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
292. senescence IN NATURAL POPULATIONS OF MAMMALS: A COMPARATIVE STUDY
293. Grading score system: A method for evaluation of the degree of senescence in senescence Accelerated Mouse (SAM)
294. Oncogenic ras and p53 Cooperate To Induce Cellular senescence
295. senescence, Abscission and Cellulase Activity in Phaseolus vulgaris
296. Oncogenic BRAF Induces senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7
297. Early Immune senescence in HIV Disease
298. The role of senescence and immortalization in carcinogenesis
299. Leaf senescence: Signals, Execution, and Regulation
300. Cellular senescence and chromatin structure
301. Cellular senescence in vivo: a barrier to tumorigenesis
302. Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells,
303. The shaping of senescence in the wild
304. Molecular Dissection of Formation of senescence-Associated Heterochromatin Foci
305. Short Telomeres Limit Tumor Progression In Vivo by Inducing senescence
306. Zeb1 links epithelial-mesenchymal transition and cellular senescence
307. Cellular senescence controls fibrosis in wound healing
308. Jasmonates: Hormonal regulators or stress factors in leaf senescence?
309. Effect of extrinsic mortality on the evolution of senescence in guppies
310. Replicative senescence and Oxidant‐Induced Premature senescence: Beyond the Control of Cell Cycle Checkpoints
311. Mitochondrial Dysfunction Accounts for the Stochastic Heterogeneity in Telomere-Dependent senescence
312. Immunologic Deficiencies in senescence
313. Telomeres and senescence: The history, the experiment, the future
314. A senescence Program Controlled by p53 and p16INK4a Contributes to the Outcome of Cancer Therapy
315. senescence As an Anticancer Mechanism
316. Changes in antioxidative enzymes in cucumber cotyledons during natural senescence: comparison with those during dark‐induced senescence
317. senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells
318. MicroRNA 217 Modulates Endothelial Cell senescence via Silent Information Regulator 1
319. The Role of Cellular senescence in Skin Aging
320. Identification of three genetic loci controlling leaf senescence in Arabidopsis thaliana
321. Pathobiology of the senescence-accelerated mouse (SAM)
322. Biochemistry of senescence
323. Optimization of edible coating composition to retard strawberry fruit senescence
324. Population cycles in microtines: The senescence hypothesis
325. Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion?
326. In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs
327. Mitochondria: are they the seat of senescence?
328. senescence of red blood cells: progress and problems
329. Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis.
330. T cell senescence.
331. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
332. Escape from senescence in human diploid fibroblasts induced directly by mutant p53.
333. senescence, ageing and death of the whole plant
334. Reactive Oxygen Species as Mediators of Cellular senescence
335. TAp63 induces senescence and suppresses tumorigenesis in vivo
336. p53, ROS and senescence in the control of aging
337. Cellular senescence in aging and age-related disease: from mechanisms to therapy
338. Cellular senescence: hot or what?
339. Microglial senescence: does the brain’s immune system have an expiration date?
340. A genetic analysis of senescence in Drosophila
341. Non‐destructive optical detection of pigment changes during leaf senescence and fruit ripening
342. Role of CMV in immune senescence
343. JunD Protects Cells from p53-Dependent senescence and Apoptosis
344. MORPHOLOGIC CHANGES ACCOMPANYING senescence OF CULTURED HUMAN DIPLOID CELLS
345. Quantitative assessment of markers for cell senescence
346. Caspase inhibition switches doxorubicin-induced apoptosis to senescence
347. Replicative senescence of human fibroblast-like cells in culture
348. Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis
349. A senescence-associated gene of Arabidopsis thaliana is distinctively regulated during natural and artificially induced leaf senescence
350. Impact of cellular senescence signature on ageing research
351. DNA damage response and cellular senescence in tissues of aging mice
352. Lack of Replicative senescence in Normal Rodent Glia
353. Peroxisome senescence in Human Fibroblasts
354. Effects of estrogen on growth plate senescence and epiphyseal fusion
355. DNA damage, cellular senescence and organismal ageing: causal or correlative?
356. Lack of Replicative senescence in Cultured Rat Oligodendrocyte Precursor Cells
357. Human Platelet senescence
358. Feedback between p21 and reactive oxygen production is necessary for cell senescence
359. Oncogene-Induced senescence Pathways Weave an Intricate Tapestry
360. A Role for Diacylglycerol Acyltransferase during Leaf senescence
361. senescence-induced RNases in tomato
362. Identification of a transcription factor specifically expressed at the onset of leaf senescence
363. PRAK Is Essential for ras-Induced senescence and Tumor Suppression
364. Relation between leaf senescence and stomatal closure: senescence in light
365. Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I—effects of proliferative senescence
366. Total body irradiation selectively induces murine hematopoietic stem cell senescence
367. Is Petal senescence Due to Sugar Starvation?
368. senescence and apoptosis: dueling or complementary cell fates?
369. Cellular senescence as a tumor-protection mechanism: the essential role of counting
370. AtNAP, a NAC family transcription factor, has an important role in leaf senescence
371. Metabolism of Oat Leaves during senescence
     V. senescence in Light
372. Leaf senescence in rice plants: cloning and characterization of senescence up‐regulated genes
373. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
374. Memory T cell homeostasis and senescence during aging
375. Natal dispersal and senescence
376. Cell wall metabolism during maturation, ripening and senescence of peach fruit
377. senescence, sleep, and circadian rhythms
378. Neurologic Signs in senescence
379. Genetic regulation of embryo death and senescence
380. Lysosome-mediated processing of chromatin in senescence
381. The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence
382. senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning
383. Inside and out: the activities of senescence in cancer
384. p16Ink4a in Melanocyte senescence and Differentiation
385. Replicative senescence of human endothelial cells in vitro involves G1 arrest, polyploidization and senescence-associated apoptosis
386. Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas
387. Autophagy facilitates oncogene-induced senescence
388. Cellular senescence: A link between cancer and age-related degenerative disease?
389. senescence‐associated intrinsic mechanisms of osteoblast dysfunctions
390. Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer
391. Secretion of Vascular Endothelial Growth Factor by Primary Human Fibroblasts at senescence
392. Transcription factors regulating leaf senescence in Arabidopsis thaliana
393. Expression of senescence‐enhanced genes in response to oxidative stress
394. A Phylogenetic Evaluation of Whether Endophytes Become Saprotrophs at Host senescence
395. Mitochondria, telomeres and cell senescence
396. Mechanisms, Functional Consequences, and Potential Therapeutics for Cellular senescence
397. Evidence for programmed cell death during leaf senescence in plants [1998]
398. senescence: a new weapon for cancer therapy
399. Ethylene Production During senescence of Flowers
400. Die and let live: leaf senescence contributes to plant survival under drought stress
401. Astrocyte senescence as a Component of Alzheimer’s Disease
402. Alcohols and Carnation senescence
403. AGE‐SPECIFIC SURVIVAL IN FIVE POPULATIONS OF UNGULATES: EVIDENCE OF senescence
404. Fibroblast senescence in pressure ulcers
405. Mental efficiency in senescence.
406. Chloroplasts regulate leaf senescence: delayed senescence in transgenic ndhF-defective tobacco
407. Retarded senescence in an insular population of Virginia opossums (Didelphis virginiana)
408. Ink4a/Arf links senescence and aging
409. Retardation of radish leaf senescence by polyamines
410. Salicylic acid has a role in regulating gene expression during leaf senescence
411. DNA Damage Is Able to Induce senescence in Tumor Cells in Vitro and in Vivo
412. Hormone receptor changes during adulthood and senescence: significance for aging research.
413. Vascular smooth muscle cell senescence in atherosclerosis
414. How might replicative senescence contribute to human ageing?
415. Age-related changes in learning and memory in the senescence-accelerated mouse (SAM)
416. Angiotensin II accelerates endothelial progenitor cell senescence through induction of oxidative stress
417. INDIVIDUAL DIFFERENCES, LONGEVITY, AND REPRODUCTIVE senescence IN BIGHORN EWES
418. DNA damage checkpoint kinase Chk2 triggers replicative senescence
419. Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and senescence
420. Targets of the WRKY53 transcription factor and its role during leaf senescence in Arabidopsis
421. Reversal of senescence in Mouse Fibroblasts through Lentiviral Suppression of p53
422. senescence‐associated proteases in plants
423. Cigarette Smoke Induces senescence in Alveolar Epithelial Cells
424. senescence-Associated Exosome Release from Human Prostate Cancer Cells
425. Aging and Cancer: The Double‐Edged Sword of Replicative senescence
426. The evolution of premature reproductive senescence and menopause in human females
427. senescence of an Antibody-forming Cell Clone
428. miR-22 represses cancer progression by inducing cellular senescence
429. Telomerase Inhibition, Telomere Shortening, and senescence of Cancer Cells by Tea Catechins
430. cGAS is essential for cellular senescence
431. Effect of Kinetin on Protein & Nucleic Acid Metabolism in Xanthium Leaves During senescence
432. A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
433. Retardation of the senescence of Cultured Human Diploid Fibroblasts by Carnosine
434. Plant senescence
435. Immune Activation and CD8+ T-Cell Differentiation towards senescence in HIV-1 Infection
436. Telomere Shortening Triggers senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a
437. Mitogen‐activated protein kinase p38 defines the common senescence‐signalling pathway
438. Werner syndrome protein limits MYC-induced cellular senescence
439. Identification of senescence-associated genes from daylily petals
440. Cellular senescence in naevi and immortalisation in melanoma: a role for p16?
441. Leaf senescence and nutrient remobilisation in barley and wheat
442. Stay-green regulates chlorophyll and chlorophyll-binding protein degradation during senescence
443. Overcoming cellular senescence in human cancer pathogenesis
444. The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing
445. PHOTOCONTROL OF LEAF senescence
446. Hallmarks of Cellular senescence
447. Inhibition of p21‐mediated ROS accumulation can rescue p21‐induced senescence
448. Vascular cell senescence and vascular aging
449. The p16INK4a-RB pathway : molecular link between cellular senescence and tumor suppression
450. T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment
451. Loss of linker histone H1 in cellular senescence
452. Fibroblasts cultured from venous ulcers display cellular characteristics of senescence
453. senescence and programmed cell death: substance or semantics?
454. Rapid induction of senescence in human cervical carcinoma cells
455. Networking senescence-Regulating Pathways by Using Arabidopsis Enhancer Trap Lines
456. Synthetic lethal metabolic targeting of cellular senescence in cancer therapy
457. DOES INCREASED MORTALITY FAVOR THE EVOLUTION OF MORE RAPID senescence?
458. Relation between senescence and stomatal opening: senescence in darkness
459. Measuring senescence in wild animal populations: towards a longitudinal approach
460. Cell senescence in the Aging Kidney
461. p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC
462. Replicative senescence and Cell Immortality: The Role of Telomeres and Telomerase
463. Cellular senescence, ageing and disease
464. Effect of sugar-induced senescence on gene expression and implications for the regulation of senescence in Arabidopsis
465. Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis
466. Victorin Induction of an Apoptotic/senescence–like Response in Oats
467. The oxidative hypothesis of senescence
468. Accumulation of Short Telomeres in Human Fibroblasts Prior to Replicative senescence
469. Stress-induced Premature senescence (SIPS)
470. Significant Role for p16INK4a in p53-Independent Telomere-Directed senescence
471. Is β-Galactosidase Staining a Marker of senescence in Vitro and in Vivo?
472. Role of polyamines and ethylene as modulators of plant senescence
473. Aging and Immortality: Quasi-Programmed senescence and Its Pharmacologic Inhibition
474. Ovarian Dynamics in Heliconiine Butterflies: Programmed senescence versus Eternal Youth
475. Inflammatory signaling and cellular senescence
476. PROTEIN SYNTHESIS AND DEGRADATION DURING AGING AND senescence
477. Extracellular Invertase Is an Essential Component of Cytokinin-Mediated Delay of senescence
478. Physical activity and immune senescence in men.
479. Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence
480. Mitochondrial Dysfunction Induces senescence with a Distinct Secretory Phenotype
481. Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast
482. Regulation of mitochondrial respiration in senescence
483. Induction of EMT by Twist Proteins as a Collateral Effect of Tumor-Promoting Inactivation of Premature senescence
484. Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced senescence
485. Role of Cytokinins in Carnation Flower senescence
486. Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes
487. The roles of senescence and telomere shortening in cardiovascular disease
488. Vertical saccades in senescence.
489. Variations in senescence and Longevity Include the Possibility of Negligible senescence
490. Lipid turnover during senescence
491. Mechanisms of endothelial senescence
492. Natural senescence of Pea Leaves (An Activated Oxygen-Mediated Function for Peroxisomes)
493. Water Stress during Seed Filling and Leaf senescence in Soybean
494. Stress-induced premature senescence and tissue ageing
495. Increase of deleted mitochondrial DNA in the striatum in Parkinson’s disease and senescence
496. Defining cellular senescence in IMR-90 cells: a flow cytometric analysis
497. Cellular senescence mechanisms in chronic wound healing
498. Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation
499. The role of CD8+ T‐cell replicative senescence in human aging
500. Telomere Erosion and senescence in Human Articular Cartilage Chondrocytes
501. Cellular senescence and DNA synthesis: Thymidine incorporation as a measure of population age in human diploid cells
502. A Novel Role for High-Mobility Group A Proteins in Cellular senescence and Heterochromatin Formation
503. Healing and Hurting: Molecular Mechanisms, Functions, and Pathologies of Cellular senescence
504. Signal transduction in leaf senescence
505. senescence in seeds.
506. Growth stimulation leads to cellular senescence when the cell cycle is blocked
507. Epidermal differentiation, apoptosis, and senescence: common pathways?
508. Cellular senescence in the glaucomatous outflow pathway
509. Leaf senescence Is Delayed in Tobacco Plants Expressing the Maize Homeobox Gene knotted1 under the Control of a senescence-Activated Promoter
510. Induction of cellular senescence in immortalized cells by human chromosome 1
511. senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells
512. Stabilization of Oat Leaf Protoplasts through Polyamine-mediated Inhibition of senescence
513. Androgens in male senescence
514. Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4a
515. Mitogenic signalling and the p16INK4a–Rb pathway cooperate to enforce irreversible cellular senescence
516. Programmed Cell Death during Pollination-Induced Petal senescence in Petunia
517. Developmental and age-related processes that influence the longevity and senescence of photosynthetic tissues in arabidopsis.
518. Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?
519. Reactive oxygen species and oxidative burst: Roles in stress, senescence and signal transducation in plants
520. Molecular and Biochemical Characterization of Postharvest senescence in Broccoli
521. TWIN STUDIES ON senescence
522. senescence of the Human Immune System
523. Longevity and senescence in plants
524. senescence‐specific regulation of catalases in Arabidopsis thaliana (L.) Heynh
525. Extended culture of mouse embryo cells without senescence: inhibition by serum
526. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes
527. Desiccation, Flight, Glycogen, and Postponed senescence in Drosophila metanogaster
528. Klotho as a regulator of oxidative stress and senescence
529. Twisted epithelial–mesenchymal transition blocks senescence
530. BENZYLADENINE EFFFCTS ON BEAN LEAF GROWTH AND senescence
531. The Strategy of senescence
532. Differences in gene expression between natural and artificially induced leaf senescence
533. Aging and Replicative senescence Have Related Effects on Human Stem and Progenitor Cells
534. Requirement for p27KIP1 in Retinoblastoma Protein-Mediated senescence
535. Replicative senescence in Human Uroepithelial Cells
536. MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
537. Superoxide Dismutase 1 Knock-down Induces senescence in Human Fibroblasts
538. Cellular senescence in vivo: Its relevance in ageing and cardiovascular disease
539. Evolutionary Perspectives on Human senescence
540. T Cell Replicative senescence in Human Aging
541. Possible Mechanisms of Adaptive Leaf senescence
542. Sorghum stay-green QTL individually reduce post-flowering drought-induced leaf senescence
543. senescence Mutants of Saccharomyces cerevisiae With a Defect in Telomere Replication Identify Three Additional EST Genes
544. senescence AND REPRODUCTIVE VALUE IN SPARROWHAWKS
545. Understanding insect life histories and senescence through a resource allocation lens
546. Klotho suppresses RIG-I-mediated senescence-associated inflammation
547. Cardiac Muscle Changes in senescence
548. Ethylene as a Regulator of senescence in Tobacco Leaf Discs
549. Aspirin reduces endothelial cell senescence
550. senescence IN NATURAL POPULATIONS OF MAMMALS: A REANALYSIS
551. Growth and senescence of antibody‐forming cells
552. Regulation of a senescence Checkpoint Response by the E2F1 Transcription Factor and p14ARF Tumor Suppressor
553. INK4a-de®cient human diploid ®broblasts areresistant to RAS-induced senescence
554. Response of a primary human fibroblast cell line to H2O2: senescence-like growth arrest or apoptosis?
555. A senescence-like Phenotype Distinguishes Tumor Cells That Undergo Terminal Proliferation Arrest after Exposure to Anticancer Agents
556. Cdk2 suppresses cellular senescence induced by the c-myc oncogene
557. Identification of a promoter region responsible for the senescence-specific expression of SAG12
558. Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix
559. ANTAGONISTIC PLEIOTROPY, MORTALITY SOURCE INTERACTIONS, AND THE EVOLUTIONARY THEORY OF senescence
560. Wound chronicity and fibroblast senescence – implications for treatment
561. Insect thermal tolerance: what is the role of ontogeny, ageing and senescence?
562. THE CORRELATION BETWEEN OXIDATIVE STRESS AND LEAF senescence DURING PLANT DEVELOPMENT #
563. p38MAPK is a novel DNA damage response‐independent regulator of the senescence‐associated secretory phenotype
564. Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells
565. Effect of Pod Removal on Leaf senescence in Soybeans
566. On the senescence of ovules in cherries
567. OsNAP connects abscisic acid and leaf senescence by fine-tuning abscisic acid biosynthesis and directly targeting senescence-associated genes in rice
568. Acceleration of senescence in the collared flycatcher Ficedula albicollis by reproductive costs
569. Rapid and costly ageing in wild male flies
570. Transcription Analysis of Arabidopsis Membrane Transporters and Hormone Pathways during Developmental and Induced Leaf senescence
571. Role of p14ARF in Replicative and Induced senescence of Human Fibroblasts
572. Leaf senescence and Starvation-Induced Chlorosis Are Accelerated by the Disruption of an Arabidopsis Autophagy Gene
573. The Role of Protein Synthesis in the senescence of Leaves
574. Emergence, Elongation, and senescence of Maize Silks
575. Hemangioblastic Derivatives from Human Induced Pluripotent Stem Cells Exhibit Limited Expansion and Early senescence
576. Immune senescence
577. Glucose-Induced Replicative senescence in Mesenchymal Stem Cells
578. p63 deficiency activates a program of cellular senescence and leads to accelerated aging
579. Weak p53 permits senescence during cell cycle arrest
580. Aging and sensory senescence.
581. Pathways connecting telomeres and p53 in senescence, apoptosis, and cancer
582. Tumour suppression by p53: the importance of apoptosis and cellular senescence
583. Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells
584. Does a Sentinel or a Subset of Short Telomeres Determine Replicative senescence?
585. Markers for hypersensitive response and senescence show distinct patterns of expression
586. The role of nuclear lamin B1 in cell proliferation and senescence
587. Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis
588. Post‐traumatic osteoarthritis: The role of accelerated chondrocyte senescence
589. senescence and the healing rates of venous ulcers
590. The senescence‐Related Mitochondrial/Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem Cells
591. senescence and Receptivity of Maize Silks
592. Molecular signature of oncogenic ras-induced senescence
593. senescence and Embedded-Figure Performance in Vision and Touch
594. Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells
595. Role of calcium in ripening and senescence
596. Pheophytin Pheophorbide Hydrolase (Pheophytinase) Is Involved in Chlorophyll Breakdown during Leaf senescence in Arabidopsis
597. Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence
598. Id-1 Delays senescence but Does Not Immortalize Keratinocytes
599. Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular senescence
600. Cellular aging and senescence
601. Mitochondrial production of pro-oxidants and cellular senescence
602. p16INK4a can initiate an autonomous senescence program
603. Genetic analysis of cellular senescence
604. A comparison of the expression patterns of several senescence-associated genes in response to stress and hormone treatment
605. Replicative senescence Revisited
606. Evolution of accelerated senescence in laboratory populations of Drosophila
607. Cytoplasmic chromatin triggers inflammation in senescence and cancer
608. Hormone-directed Transport of Metabolites and its possible Role in Plant senescence
609. The evolution of senescence in fish
610. senescence‐associated lncRNAs: senescence‐associated long noncoding RNAs
611. Regulation of Leaf senescence by Cytokinin, Sugars, and Light
612. Cellular senescence in the pathogenesis of benign prostatic hyperplasia
613. A causal link between respiration and senescence in Podospora anserina
614. Early Compositional Changes during Postharvest senescence of Broccoli
615. HDA6 is required for jasmonate response, senescence and flowering in Arabidopsis
616. Arabidopsis Cytokinin Receptor Mutants Reveal Functions in Shoot Growth, Leaf senescence, Seed Size, Germination, Root Development, and Cytokinin Metabolism
617. Leaf senescence and activities of the antioxidant enzymes
618. Cellular senescence drives age-dependent hepatic steatosis
619. Cloning and characterization of tomato leaf senescence-related cDNAs
620. Role of Telomerase in Cell senescence and Oncogenesis
621. Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands
622. senescence in fishes
623. Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways
624. CD28 extinction in human T cells: altered functions and the program of T‐cell senescence
625. Mitochondrial Dysfunction in the senescence Accelerated Mouse (SAM)
626. Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts
627. Adriamycin-induced senescence in Breast Tumor Cells Involves Functional p53 and Telomere Dysfunction
628. MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8
629. senescence in natural populations of animals: Widespread evidence and its implications for bio-gerontology
630. Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence.
631. The Control of Autumn senescence in European Aspen
632. Genetic regulation of primitive hematopoietic stem cell senescence
633. DNA fragmentation is regulated by ethylene during carpel senescence in Pisum sativum
634. AUXIN RESPONSE FACTOR1 and AUXIN RESPONSE FACTOR2 regulate senescence and floral organ abscission in Arabidopsis thaliana
635. p63–microRNA feedback in keratinocyte senescence
636. Role of the Ascorbate-Glutathione Cycle of Mitochondria and Peroxisomes in the senescence of Pea Leaves
637. Effects of PSAG12-IPT Gene Expression on Development and senescence in Transgenic Lettuce
638. Involvement of free radicals in ageing: a consequence or cause of senescence
639. The Remobilization of Nitrogen Related to Leaf Growth and senescence in Rice Plants (Oryza sativa L.)
640. NF-κB inhibition delays DNA damage–induced senescence and aging in mice
641. Decreased beta-adrenergic responsiveness during senescence.
642. Membrane phospholipid catabolism and Ca2+ activity in control of senescence
643. Mechanism of Monocarpic senescence in Rice
644. Oxidative stress occurs during soybean nodule senescence
645. Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence.
646. Longevity and the genetic determination of collagen glycoxidation kinetics in mammalian senescence
647. High levels of antioxidant enzymes correlate with delayed senescence in nonnetted muskmelon fruits
648. Relationship between Photosynthesis and Chlorophyll Content during Leaf senescence of Rice Seedlings
649. The Role of Ethylene in the senescence of Oat Leaves
650. Splicing into senescence: The Curious Case of p16 and p19ARF
651. The Gene Expression Program of Prostate Fibroblast senescence Modulates Neoplastic Epithelial Cell Proliferation through Paracrine Mechanisms
652. Cellular senescence and chromatin organisation
653. Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53
654. Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence
655. DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?
656. Ageing, telomeres, senescence, and liver injury
657. Evidence That Aging And Amyloid Promote Microglial Cell senescence
658. Cellular senescence and DNA repair
659. Rethinking the evolutionary theory of aging: Transfers, not births, shape senescence in social species
660. Vascular Smooth Muscle Cells Undergo Telomere-Based senescence in Human Atherosclerosis
661. Assessing Cell and Organ senescence Biomarkers
662. Molecular Regulation of Melanocyte senescence
663. Premature senescence of endothelial cells: Methusaleh’s dilemma
664. Resistance to Environmental Stress in Drosophila melanogaster Selected for Postponed senescence
665. Oxidative stress induces senescence in chondrocytes
666. p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence
667. HIF1α delays premature senescence through the activation of MIF
668. Retardation of leaf senescence by benzyladenine in intact bean plants
669. Cellular senescence and the aging brain
670. Carnosine as a Potential Anti-senescence Drug
671. The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15Ink4b
672. Cellular aging–clonal senescence. A review (Part I)
673. Is Accelerated senescence a Cost of Reproduction?
674. Astrocytes in the aging brain express characteristics of senescence‐associated secretory phenotype
675. MicroRNAs linking inflamm-aging, cellular senescence and cancer
676. senescence-associated inflammatory responses: aging and cancer perspectives
677. Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53‐dependent cellular senescence
678. Altered fruit ripening and leaf senescence in tomatoes expressing an antisense ethylene‐forming enzyme transgene
679. Antioxidants Inhibit Nuclear Export of Telomerase Reverse Transcriptase and Delay Replicative senescence of Endothelial Cells
680. The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4
681. Evidence that exposure of the telomere 3′ overhang sequence induces senescence
682. Physiological compensation for loss of afferent synapses in rat hippocampal granule cells during senescence.
683. Ribulose Bisphosphate Carboxylase and Proteolytic Activity in Wheat Leaves from Anthesis through senescence
684. Spontaneous age-associated amyloidosis in senescence-accelerated mouse (SAM)
685. Cellular senescence: Molecular Mechanisms, In Vivo Significance, and Redox Considerations
686. Overexpression of Arabidopsis Hexokinase in Tomato Plants Inhibits Growth, Reduces Photosynthesis, and Induces Rapid senescence
687. senescence induction; a possible cancer therapy
688. Cell senescence and Its Implications for Nephrology
689. Accelerated senescence: An emerging role in tumor cell response to chemotherapy and radiation
690. Central Role of the Proteasome in senescence and Survival of Human Fibroblasts
     INDUCTION OF A senescence-LIKE PHENOTYPE UPON ITS INHIBITION AND RESISTANCE TO STRESS UPON ITS ACTIVATION
691. Differential Roles for Cyclin-Dependent Kinase Inhibitors p21 and p16 in the Mechanisms of senescence and Differentiation in Human Fibroblasts
692. senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts.
693. Characteristics of age-related behavioral changes in senescence-accelerated mouse SAMP8 and SAMP10
694. Mammalian Prohibitin Proteins Respond to Mitochondrial Stress and Decrease during Cellular senescence
695. Antisense suppression of phospholipase D alpha retards abscisic acid- and ethylene-promoted senescence of postharvest Arabidopsis leaves.
696. Autophagy, senescence and tumor dormancy in cancer therapy
697. senescence of immune defence in Bombus workers
698. senescence-Induced Serotonin Biosynthesis and Its Role in Delaying senescence in Rice Leaves
699. Role of T lymphocyte replicative senescence in vaccine efficacy
700. Dental senescence in a long-lived primate links infant survival to rainfall
701. The influence of sward condition on rates of herbage growth and senescence in mixed swards under continuous stocking management
702. Cytokinin Activity in Rose Petals and Its Relation to senescence
703. Evidence for Multiple Pathways to Cellular senescence
704. Arabidopsis Nitric Oxide Synthase1 Is Targeted to Mitochondria and Protects against Oxidative Damage and Dark-Induced senescence
705. Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and senescence in Neuroblastoma
706. Cellular senescence in cancer treatment: friend or foe?
707. Human chondrocyte senescence and osteoarthritis
708. Spectral Reflectance Changes Associated with Autumn senescence of Aesculus hippocastanum L. and Acer platanoides L. Leaves. Spectral Features and Relation to Chlorophyll Estimation
709. BULB-TYPE FLOWER senescence
710. Pathway analysis of senescence-associated miRNA targets reveals common processes to different senescence induction mechanisms
711. Protein oxidation and degradation during postmitotic senescence
712. Doubling potential, calendar time, and senescence of human diploid cells in culture
713. Inflammatory bowel disease-like enteritis and caecitis in a senescence accelerated mouse P1/Yit strain
714. Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis
715. mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
716. senescence Is Induced in Individually Darkened Arabidopsis Leaves, but Inhibited in Whole Darkened Plants
717. Hypoxia suppresses conversion from proliferative arrest to cellular senescence
718. RNS2: a senescence-associated RNase of Arabidopsis that diverged from the S-RNases before speciation
719. Interleukin‐22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice
720. Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts
721. Evolutionary Biology of senescence
722. Eating to exit: autophagy-enabled senescence revealed
723. Loss of CD28 expression on T lymphocytes: A marker of replicative senescence
724. senescence‐associated vacuoles with intense proteolytic activity develop in leaves of Arabidopsis and soybean
725. senescence-associated beta-galactosidase histochemistry for the primate eye.
726. Cytokine loops driving senescence
727. MicroRegulators come of age in senescence
728. DNA end joining becomes less efficient and more error-prone during cellular senescence
729. Conditional senescence in bacteria: death of the immortals
730. senescence and Death of Primitive Cells and Myocytes Lead to Premature Cardiac Aging and Heart Failure
731. Isolation and analysis of cDNAs encoding tomato cysteine proteases expressed during leaf senescence
732. Negligible senescence in the longest living rodent, the naked mole-rat: insights from a successfully aging species
733. Mate Choice, Sexual Conflict, and Evolution of senescence
734. Markers of cellular senescence. Telomere shortening as a marker of cellular senescence
735. Stress-Induced Legume Root Nodule senescence. Physiological, Biochemical, and Structural Alterations
736. Chlorophyll b reduction during senescence of barley seedlings
737. Categories of Petal senescence and Abscission: A Re-evaluation
738. Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a senescence-like Arrest Mediated by p27Kip1
739. Relation between Nitrogen and Ribulose-1,5-bisphosphate Carboxylase in Rice Leaves from Emergence through senescence
740. ETHYLENE-INSENSITIVE3 Is a senescence-Associated Gene That Accelerates Age-Dependent Leaf senescence by Directly Repressing miR164 Transcription in Arabidopsis
741. TP53 and MTOR crosstalk to regulate cellular senescence
742. senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans
743. Physiological and pathological consequences of cellular senescence
744. Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts
745. senescence from G2 arrest, revisited
746. ORS1, an H2O2-Responsive NAC Transcription Factor, Controls senescence in Arabidopsis thaliana
747. THE KINETICS OF senescence
748. Arbuscular mycorrhizal symbiosis can alleviate drought‐induced nodule senescence in soybean plants
749. High-Resolution Temporal Profiling of Transcripts during Arabidopsis Leaf senescence Reveals a Distinct Chronology of Processes and Regulation
750. The evolution of senescence from a comparative perspective
751. Relationship between Ethylene Evolution and senescence in Morning-Glory Flower Tissue
752. WRKY22 transcription factor mediates dark-induced leaf senescence in Arabidopsis
753. senescence of nickel-transformed cells by an X chromosome: possible epigenetic control
754. Hydrogen sulfide acts as a regulator of flower senescence in plants
755. Gene expression during anthesis and senescence in Iris flowers
756. Induced senescence of Intact Wheat Seedlings and Its Reversibility
757. Oncogene-induced senescence: the bright and dark side of the response
758. miR-29 and miR-30 regulate B-Myb expression during cellular senescence
759. Negligible senescence during Reproductive Dormancy in Drosophila melanogaster
760. Delayed Leaf senescence in Tobacco Plants Transformed with tmr, a Gene for Cytokinin Production in Agrobacterium.
761. Monitoring Tumorigenesis and senescence In Vivo with a p16INK4a-Luciferase Model
762. Endothelial Cell senescence
763. Hormonal changes during salinity-induced leaf senescence in tomato (Solanum lycopersicum L.)
764. Short Periods of Water Stress during Seed Filling, Leaf senescence, and Yield of Soybean
765. senescence, nutrient remobilization, and yield in wheat and barley
766. senescence and the Genetic-Correlation Hang-Up
767. REVIEW ARTICLE. p53: GUARDIAN OF CELLULAR senescence
768. Phospholipase D in cellular senescence
769. Rice NON-YELLOW COLORING1 Is Involved in Light-Harvesting Complex II and Grana Degradation during Leaf senescence
770. Delayed leaf senescence in ethylene‐deficient ACC‐oxidase antisense tomato plants: molecular and physiological analysis
771. Source : sink ratio and leaf senescence in maize:: I. Dry matter accumulation and partitioning during grain filling
772. Carotenoid catabolism during leaf senescence and its control by light
773. senescence: does it all happen at the ends?
774. Oxidative stress induces senescence in human mesenchymal stem cells
775. DNA damage, vascular senescence and atherosclerosis
776. Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration
777. DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion
778. Role of p21 in Apoptosis and senescence of Human Colon Cancer Cells Treated with Camptothecin
779. Oxygen free radicals in cell senescence: Are they signal transducers?
780. Genetics of cellular senescence
781. Regulation of E2Fs and senescence by PML nuclear bodies
782. Cellular senescence and cancer chemotherapy resistance
783. RNA Interference of Human Papillomavirus Type 18 E6 and E7 Induces senescence in HeLa Cells
784. senescence and immortality in hepatocellular carcinoma
785. senescence Processes in Leaf Abscission
786. Acceleration of Membrane senescence in Cut Carnation Flowers by Treatment with Ethylene
787. Oncogenic functions of tumour suppressor p21Waf1/Cip1/Sdi1: association with cell senescence and tumour-promoting activities of stromal fibroblasts
788. WRKY54 and WRKY70 co-operate as negative regulators of leaf senescence in Arabidopsis thaliana
789. Calcium regulation of senescence in rose petals
790. Leaf senescence in Brassica napus: expression of genes encoding pathogenesis-related proteins
791. Leaf senescence in maize hybrids: plant population, row spacing and kernel set effects
792. The Effects of Ear Removal on senescence and Metabolism of Maize
793. Time, telomeres and tumours: is cellular senescence more than an anticancer mechanism?
794. Asexual metazoans undergo senescence.
795. The biochemistry and regulation of senescence in chloroplasts
796. Catalase and Peroxidase in Primary Bean Leavesduring Development and senescence
797. Correlation of Xylem Sap Cytokinin Levels with Monocarpic senescence in Soybean
798. Induction of senescence by oncogenic ras
799. Mechanisms of polyamine action during senescence responses induced by osmotic stress
800. Papillomavirus E2 induces senescence in HPV‐positive cells via pRB‐ and p21CIP‐dependent pathways
801. Role of Ethylene in the senescence of Detached Rice Leaves
802. senescence, Stress, and Reactive Oxygen Species
803. A Role for Glutamine Synthetase in the Remobilization of Leaf Nitrogen during Natural senescence in Rice Leaves
804. Predatory senescence in ageing wolves
805. Hydrogen Sulfide Protects Against Cellular senescence via S-Sulfhydration of Keap1 and Activation of Nrf2
806. Estrogen reduces endothelial progenitor cell senescence through augmentation of telomerase activity
807. ABA receptor PYL9 promotes drought resistance and leaf senescence
808. senescence-associated reprogramming promotes cancer stemness
809. Arabidopsis AtNAP regulates fruit senescence
810. Reversible senescence in Human CD4+CD45RA+CD27− Memory
811. T Cell Activation and senescence Predict Subclinical Carotid Artery Disease in HIV-Infected Women
812. Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition
813. Evolutionary mechanisms of senescence
814. Changes in Capsaicinoids during Development, Maturation, and senescence of Chile Peppers and Relation with Peroxidase Activity
815. The Vacuole and Cell senescence
816. The role of ubiquitin in plant senescence and stress responses
817. DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly
818. Induction of senescence in human malignant glioma cells by p16INK4A
819. Leaf peroxisomes are directly transformed to glyoxysomes during senescence of pumpkin cotyledons
820. Convergence and divergence in gene expression profiles induced by leaf senescence and 27 senescence‐promoting hormonal, pathological and environmental stress treatments
821. senescence mechanisms of nucleus pulposus chondrocytes in human intervertebral discs
822. Transcriptional regulation of cellular senescence
823. Molecular and Cell Biology of Replicative senescence
824. Ethylene-regulated expression of a carnation cysteine proteinase during flower petal senescence
825. senescence and death of plant organs: Nutrient recycling and developmental regulation
826. p16Ink4a overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors
827. Chemokines Acting via CXCR2 and CXCR4 Control the Release of Neutrophils from the Bone Marrow and Their Return following senescence
828. The senescence of the Immune System
829. Telomere-driven replicative senescence is a stress response
830. Methyl Jasmonate, Calcium, and Leaf senescence in Rice
831. Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras
832. Smurf2 up-regulation activates telomere-dependent senescence
833. Autophagy and senescence
834. Critical pathways in cellular senescence and immortalization revealed by gene expression profiling
835. The evolutionary ecology of pre- and post-meiotic sperm senescence
836. Inhibition of phospholipase D by lysophosphatidylethanolamine, a lipid-derived senescence retardant
837. Chlorophyll-a degradation during cellular senescence and death
838. Integrated Signaling in Flower senescence
839. Mechanisms of Disease: role of chondrocytes in the pathogenesis of osteoarthritis—structure, chaos and senescence
840. Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency
841. PML interaction with p53 and its role in apoptosis and replicative senescence
842. Thidiazuron—a potent inhibitor of leaf senescence in Alstroemeria
843. The disparity between human cell senescence in vitro and lifelong replication in vivo
844. Ethylene receptor expression is regulated during fruit ripening, flower senescence and abscission
845. T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infection
846. Expression of Caveolin-1 Induces Premature Cellular senescence in Primary Cultures of Murine Fibroblasts
847. A Systematic Screen for CDK4/6 Substrates Links FOXM1 Phosphorylation to senescence Suppression in Cancer Cells
848. Stress-induced premature senescence and replicative senescence are different phenotypes, proteomic evidence
849. Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)
850. Endogenous Human Papillomavirus E6 and E7 Proteins Differentially Regulate Proliferation, senescence, and Apoptosis in HeLa Cervical Carcinoma Cells
851. Transcriptome analysis of senescence in the flag leaf of wheat (Triticum aestivum L.)
852. Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-κB
853. The Relation of Autoǵamy to senescence and Rejuvenescence in Paramecium aurelia
854. senescence and Genetic Load: Evidence from Tribolium
855. senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform
856. Leaf senescence – not just a ‘wear and tear’ phenomenon
857. Immune senescence: Mechanisms and Clinical Implications
858. Involvement of the INK4a/Arf gene locus in senescence
859. Free radical oxidation of brain proteins in accelerated senescence and its modulation by N-tert-butyl-α-phenylnitrone
860. ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence
861. Errors in Protein Synthesis and Clonal senescence in Fungi
862. The E3 SUMO Ligase PIASy Is a Regulator of Cellular senescence and Apoptosis
863. miRNA-205 Suppresses Melanoma Cell Proliferation and Induces senescence via Regulation of E2F1 Protein
864. Hidden costs of infection: Chronic malaria accelerates telomere degradation and senescence in wild birds
865. Replicative senescence of CD8 T cells: effect on human ageing
866. Studies on Soybean Nodule senescence
867. Cellular senescence: Its role in tumor suppression and aging
868. Evidence for the function of the free radical gas — nitric oxide (NO•) — as an endogenous maturation and senescence regulating factor in higher plants
869. AtATG18a is required for the formation of autophagosomes during nutrient stress and senescence in Arabidopsis thaliana
870. Propagation and senescence of human marrow stromal cells in culture: a simple colony‐forming assay identifies samples with the greatest potential to propagate and differentiate
871. senescence Regulation by the p53 Protein Family
872. Cell surface-bound IL-1α is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network
873. mTOR Inhibition Prevents Epithelial Stem Cell senescence and Protects from Radiation-Induced Mucositis
874. Cellular lifespan and senescence signaling in embryonic stem cells
875. Lung fibroblasts from patients with emphysema show markers of senescence in vitro
876. Future atmospheric CO2 leads to delayed autumnal senescence
877. Sugars, senescence, and ageing in plants and heterotrophic organisms
878. Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation
879. Mutation and senescence: where genetics and demography meet
880. miR-200c is upregulated by oxidative stress and induces endothelial cell apoptosis and senescence via ZEB1 inhibition
881. ATR signaling can drive cells into senescence in the absence of DNA breaks
882. OPTIMALITY THEORY, GOMPERTZ’ LAW, AND THE DISPOSABLE SOMA THEORY OF senescence
883. Inhibition of ethylene synthesis and senescence in carnation by ethanol.
884. In vitro simulation of senescence-related membrane damage by ozone-induced lipid peroxidation
885. Telomere-dependent senescence
886. Stress-induced senescence in human and rodent astrocytes
887. The evolutionary basis of leaf senescence: Method to the madness?
888. Leaf Proteolytic Activities and senescence during Grain Development of Field-grown Corn (Zea mays L.)
889. Hypoxia, MTOR and autophagy
     Converging on senescence or quiescence
890. Long‐term exogenous application of melatonin delays drought‐induced leaf senescence in apple
891. Integration of soybean pod development and monocarpic senescence
892. Tissue damage and senescence provide critical signals for cellular reprogramming in vivo
893. Unexpected Pieces to the senescence Puzzle
894. Cell senescence: Role in Aging and Age-Related Diseases
895. Disposable-soma senescence mediated by sexual selection in an ungulate
896. Reactive oxygen species and hematopoietic stem cell senescence
897. Biochemical changes related to aging in the senescence-accelerated mouse
898. Programmed senescence of plant organs
899. SOCS1 Links Cytokine Signaling to p53 and senescence
900. The role of ascorbic acid in the control of flowering time and the onset of senescence
901. Autophagy and senescence in Cancer Therapy
902. Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer
903. Aging in Legume Symbiosis. A Molecular View on Nodule senescence in Medicago truncatula
904. A gene regulatory network controlled by the NAC transcription factor ANAC092/AtNAC2/ORE1 during salt‐promoted senescence
905. DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence
906. Evidence of cell loss from the rat retina during senescence
907. Evidence for a senescence-Associated Gene Induced by Darkness
908. Ascorbic acid, a familiar small molecule intertwined in the response of plants to ozone, pathogens, and the onset of senescence
909. Targeting cellular senescence prevents age-related bone loss in mice
910. Executing Cell senescence
911. Aging and senescence in plant developent.
912. Cortical bone senescence and mineral bone density of the humerus
913. Control of cellular senescence by CPEB
914. Morphological and contractile characteristics of rat cardiac myocytes from maturation to senescence
915. p16/pRb Pathway Alterations Are Required for Bypassing senescence in Human Prostate Epithelial Cells
916. Vemurafenib Induces senescence Features in Melanoma Cells
917. Role of growth regulators in the senescence of Arabidopsis thaliana leaves
918. Pigment dynamics and autumn leaf senescence in a New England deciduous forest, eastern USA
919. Suppression of tumor growth by senescence in virally transformed human fibroblasts
920. Factors that accelerate or retard red blood cell senescence.
921. IndependentInductionofsenescencebyp16INK4
922. Multiple pathways to cellular senescence: Role of telomerase repressors
923. Octopus senescence: The Beginning of the End
924. A new member of the Arabidopsis WRKY transcription factor family, AtWRKY6, is associated with both senescence‐ and defence‐related processes
925. Demographic Perspectives on Human senescence
926. Molecular mechanisms of replicative senescence in endothelial cells
927. Does Maintaining Green Leaf Area in Sorghum Improve Yield under Drought? I. Leaf Growth and senescence
928. Functional Aging and Gradual senescence in Zebrafish
929. A reassessment of the telomere hypothesis of senescence
930. Interrelationships of Ethylene and Abscisic Acid in the Control of Rose Petal senescence
931. Promotive Effect of Methyl Jasmonate on Oat Leaf senescence in the Light
932. senescence in podospora anserina: Amplification of a mitochondrial DNA sequence
933. Evolution of senescence in iteroparous perennial plants
934. Comparison of replicative senescence and stress‐induced premature senescence combining differential display and low‐density DNA arrays
935. POLLINATION-INDUCED COROLLA senescence
936. The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A–ARF locus in response to oncogene- and stress-induced senescence
937. Legume nodule senescence: roles for redox and hormone signalling in the orchestration of the natural aging process
938. Mitochondrial-Targeted Plastoquinone Derivatives. Effect on senescence and Acute Age-Related Pathologies
939. Dark‐inducible genes from Arabidopsisthaliana are associated with leaf senescence and repressed by sugars
940. Nitric oxide counteracts the senescence of rice leaves induced by abscisic acid
941. Cellular senescence in Type 2 Diabetes: A Therapeutic Opportunity
942. senescence of the retinal pigment epithelium
943. senescence-related serine protease in parsley
944. The Metabolism of Oat Leaves during senescence
945. Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence.
946. Markers of senescence?
947. Repair of telomeric DNA prior to replicative senescence
948. Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney
949. Regulation of detached coriander leaf senescence by 1-methylcyclopropene and ethylene
950. Stress-Activated MAP Kinase Cascades in Cellular senescence
951. Cellular senescence in Vitro
952. Inhibition of ethylene‐induced cellular senescence symptoms by 1‐methylcyclopropene, a new inhibitor of ethylene action
953. The Complex Regulation of senescence
954. Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence
955. Delayed senescence of apple leaves by exogenous melatonin treatment: toward regulating the ascorbate–glutathione cycle
956. High Levels of Brain Dolichols in Neuronal Ceroid‐Lipofuscinosis and senescence
957. An anti-aging drug today: from senescence-promoting genes to anti-aging pill
958. Homocysteine accelerates senescence and reduces proliferation of endothelial progenitor cells
959. Posttranslational Modifications of p53 in Replicative senescence Overlapping but Distinct from Those Induced by DNA Damage
960. Aging, life span, and senescence
961. The Role of Arabidopsis Rubisco Activase in Jasmonate-Induced Leaf senescence
962. Connecting autophagy to senescence in pathophysiology
963. Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts
964. miR-335 and miR-34a Promote Renal senescence by Suppressing Mitochondrial Antioxidative Enzymes
965. senescence-Accelerated Mouse (SAM) with Special References to Neurodegeneration Models, SAMP8 and SAMP10 Mice
966. Glycated Collagen I Induces Premature senescence-Like Phenotypic Changes in Endothelial Cells
967. Image analysis of GFA-positive astrocytes from adolescence to senescence
968. Escape from Therapy-Induced Accelerated Cellular senescence in p53-Null Lung Cancer Cells and in Human Lung Cancers
969. Cloning of senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen
970. Localization of senescent cell antigen on band 3
971. A senescent cell bystander effect: senescence‐induced senescence
972. senescent cell antigen is immunologically related to band 3
973. Measurement of DNA content and cell volume in senescent human fibroblasts utilizing flow multiparameter single cell analysis
974. A New LIM Protein Containing an Autoepitope Homologous to “senescent Cell Antigen”
975. Generation of senescent cell antigen on old cells initiates IgG binding to a neoantigen.
976. Mimetics of senescent cell derived inhibitors of DNA synthesis
977. senescent Keratinocytes Die by Autophagic Programmed Cell Death
978. Rapid disappearance of statin, a nonproliferating and senescent cell-specific protein, upon reentering the process
979. Molecular Mechanisms for the senescent Cell Cycle Arrest
980. Membrane Fragmentation and Ca++-Membrane Interaction : Potential Mechanisms of Shape Change in the senescent Red Cell
981. Long-Term in vitro Growth of Human T Cell Clones: Can Postmitotic ‘senescent’ Cell Populations Be Defined?
982. senescent cell derived inhibitors of DNA synthesis
983. Antigenicity, storage, and aging: physiologic autoantibodies to cell membrane and serum proteins and the senescent cell antigen
984. Aging of Cell Membrane Molecules Leads to Appearance of an Aging Antigen and Removal of senescent cells
985. Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice
986. Inhibition of intimal hyperplasia after vein grafting by in vivo transfer of human senescent cell-derived inhibitor-1 gene
987. Identification of senescent cell surface targetable protein DPP4
988. Synthetic senescent cell antigen
989. senescent vs. non-senescent cells in the human annulus in vivo: Cell harvest with laser capture microdissection and gene expression studies with microarray analysis
990. senescent cell derived inhibitors of DNA synthesis
991. Glucose transport protein is structurally and immunologically related to band 3 and senescent cell antigen
992. senescent Human Fibroblasts Resist Programmed Cell Death, and Failure to Suppress bcl2 Is Involved
993. Duration of senescent cell survival in vitro as a characteristic of organism longevity, an additional to the proliferative potential of fibroblasts
994. Antibodies to senescent cell-derived inhibiters of DNA synthesis
995. Expression of cell cycle-dependent genes in young and senescent WI-38 fibroblasts
996. Induction of senescent cell-derived inhibitor of DNA synthesis gene, SDI1, in hepatoblastoma (HepG2) cells arrested in the G2-phase of the cell cycle by 9-nitrocamptothecin.
997. Relationship between cell replication and volume in senescent human diploid fibroblasts
998. p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling
999. Cell-Cell Affinity of senescent Human Erythrocytes
1000. The Ability to Generate senescent Progeny as a Mechanism Underlying Breast Cancer Cell Heterogeneity
1001. senescent and quiescent cell inhibitors of DNA synthesis: Membrane-associated proteins
1002. Pseudomonas aeruginosa Transmigrates at Epithelial Cell-Cell Junctions, Exploiting Sites of Cell Division and senescent Cell Extrusion
1003. senescent cell antigen, band 3, and band 3 mutations in cellular aging.
1004. SCAMP4 enhances the senescent cell secretome
1005. senescent cell differentiation antigen.
1006. Reinitiation of DNA Synthesis and Cell Division in senescent Human Fibroblasts by Microinjection of Anti-p53 Antibodies
1007. Aging of cell membrane molecules: Band 3 and senescent cell antigen in neural tissue
1008. Impaired Cell Shortening and Relengthening with Increased Pacing Frequency are Intrinsic to the senescent Mouse Cardiomyocyte
1009. Dynamics of senescent Cell Formation and Retention Revealed by p14ARF Induction in the Epidermis
1010. Entry into S phase is inhibited in two immortal cell lines fused to senescent human diploid cells
1011. senescent cell death brings hopes to life
1012. Common senescent cell‐specific antibody epitopes on fibronectin in species and cells of varied origin
1013. senescent cell derived inhibitors of DNA synthesis
1014. Restoration of the responsiveness to growth factors in senescent cells by an embryonic cell extract
1015. MnSOD Upregulation Induces Autophagic Programmed Cell Death in senescent Keratinocytes
1016. Spontaneous cell transformation: Karyoplasts derived from multinucleated cells produce new cell growth in senescent human epithelial cell cultures
1017. senescent cell antigen: a terminal differentiation antigen.
1018. Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2
1019. Fibroblasts derived from Gpx1 knockout mice display senescent-like features and are susceptible to H2O2-mediated cell death
1020. Molecular Mapping of the Active Site of an Aging Antigen: senescent Cell Antigen Requires Lysine(s) for Antigenicity and Is Located on an Anion-Binding Segment of Band 3 Membrane Transport Protein
1021. Human platelet lysate stimulates high-passage and senescent human multipotent mesenchymal stromal cell growth and rejuvenation in vitro
1022. Gerontology and drug development: The challenge of the senescent cell
1023. Chlorophyll Degradation in senescent Tobacco Cell Culture (Nicotiana tabacum var. «Samsun»)
1024. Down-regulation of Akt/PKB in senescent cardiac fibroblasts impairs PDGF-induced cell proliferation
1025. Type 1 interferons contribute to the clearance of senescent cell
1026. Robust nuclear lamina-based cell classification of aging and senescent cells
1027. Simvastatin suppresses breast cancer cell proliferation induced by senescent cells
1028. Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype
1029. Appearance of the terminal senescent cell population in human diploid fibroblasts analyzed by flow cytometry
1030. Some chemotherapeutics-treated colon cancer cells display a specific phenotype being a combination of stem-like and senescent cell features
1031. mRNA levels of the differentiation-associated linker histone variant H1 zero in mitotically active and postmitotic senescent human diploid fibroblast cell populations
1032. Method To Purify and Analyze Heterogeneous senescent Cell Populations Using a Microfluidic Filter with Uniform Fluidic Profile
1033. Mapping of senescent cell antigen on brain anion exchanger protein (AE) isoforms using HPLC and fast atom bombardment ionization mass spectrometry (FAB‐MS)
1034. Evaluation of a near‐senescent human dermal fibroblast cell line and effect of amelogenin
1035. Level of macroautophagy drives senescent keratinocytes into cell death or neoplastic evasion
1036. Genes and ageing: beyond good and evil in the senescent cell
1037. Method of optimizing conditions for selectively removing a plurality of senescent cells from a tissue or a mixed cell population
1038. Complementation between senescent human diploid cells and a thymidine kinase-deficient murine cell line
1039. Targeting senescent cholangiocytes and activated fibroblasts with B‐cell lymphoma‐extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/−) mice
1040. Diet-induced weight loss is sufficient to reduce senescent cell number in white adipose tissue of weight-cycled mice
1041. Natural killer cell recognition of in vivo drug-induced senescent multiple myeloma cells
1042. senescence-associated secretory factors induced by cisplatin in melanoma cells promote non-senescent melanoma cell growth through activation of the ERK1/2-RSK1 pathway
1043. Density-gradient centrifugation enables the purification of cultured corneal endothelial cells for cell therapy by eliminating senescent cells
1044. senescent cell clearance by the immune system: Emerging therapeutic opportunities
1045. Life and Death of Neurons: The Role of senescent Cell Antigen
1046. Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability
1047. Retroviral vectors carrying senescent cell derived inhibitors 1 (SDI-1)or antisense SDI-1 nucleotide sequences
1048. In Vitro Expansion of Human Nasoseptal Chondrocytes Reveals Distinct Expression Profiles of G1 Cell Cycle Inhibitors for Replicative, Quiescent, and senescent Culture Stages
1049. Drug-Induced senescent Multiple Myeloma Cells Elicit NK Cell Proliferation by Direct or Exosome-Mediated IL15 Trans-Presentation
1050. Radiation-Induced Reprogramming of Pre-senescent Mammary Epithelial Cells Enriches Putative CD44+/CD24−/low Stem Cell Phenotype
1051. Epigallocatechin gallate suppresses premature senescence of preadipocytes by inhibition of PI3K/Akt/mTOR pathway and induces senescent cell death by regulation of Bax/Bcl-2 pathway
1052. The senescent cell epigenome
1053. CHAPTER 24 – senescent cell antigen and band 3 in aging and disease
1054. The mTORC1-autophagy pathway is a target for senescent cell elimination
1055. HPV-16 virions can remain infectious for 2 weeks on senescent cells but require cell cycle re-activation to allow virus entry
1056. Embryonic senescent cells re-enter cell cycle and contribute to tissues after birth
1057. Proteomics Analysis of Normal and senescent NG108-15 Cells: GRP78 Plays a Negative Role in Cisplatin-Induced senescence in the NG108-15 Cell Line
1058. Cell surface oligosaccharide modulation during differentiation: VI. The effect of biomodulation on the senescent and neoplastic cell phenotype
1059. Induction of Neointimal Formation by Local Gene Transfer of the Antisense senescent Cell-derived Inhibitor 1 (SDI) Delivered With the Needle Injection Catheter
1060. Antibody Dependent Cell Mediated Cytotoxicity and Phagocytosis of senescent Erythrocytes by Autologous Peripheral Blood Mononuclear Cells
1061. Phase-space description of the cell cycle: Application to noncycling, senescent, and transformed cells
1062. Effect of Overproduction of Mitochondrial Uncoupling Protein 2 on Cos7 Cells: Induction of senescent-like Morphology and Oncotic Cell Death
1063. senescent dermal fibroblasts enhance stem cell migration through CCL2/CCR2 axis
1064. Red cell aging: senescent cell antigen, band 3, and band 3 mutations associated with cellular dysfunction.
1065. Rock Inhibition Reduces senescent Cell Size
1066. The senescent Cell, SC
1067. senescent Cell Biomarkers
1068. THE senescent CELL POPULATION WITHIN NEW BONE PRODUCED BY DISTRACTION OSTEOGENESIS
1069. Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques
1070. Single senescent cell sequencing reveals heterogeneity in senescent cells induced by telomere erosion
1071. [Establishment of senescent cell model in primary rat aortic endothelial cells].
1072. THE ROLE OF THE RETINOBLASTOMA PROTEIN IN senescent CELL CYCLE EXIT, SURVIVAL, AND MORPHOLOGICAL ALTERATION
1073. Abstract 453: senescent Cell Depletion via Abt263 Augments Experimental Aortic Aneurysm Progression
1074. Aging and cancer: Cell non-autonomous effects of senescent fibroblasts on tissue microenvironment
1075. The senescent cell induced bystander effect
1076. [senescent cell antigens in the clearance of senescent cells].
1077. Material-induced senescence (MIS): Fluidity Induces senescent Type Cell Death of Lung Cancer Cells via Insulin-Like Growth Factor Binding Protein 5
1078. Abstract 361: Effects of Chronic, Intermittent senescent Cell Clearance in Combination with Lipid Lowering on Inflammation in Perivascular Adipose Tissue
1079. Active, Dormant, or on the Path to Elimination: What Does a senescent Cell Do?
1080. The connection between the cardiac glycoside‐induced senescent cell morphology and Rho/Rho kinase pathway
1081. Cloning of animals from senescent cell nuclei–what are the implications for aging research?
1082. Cell Cycle Traverse and Growth Arrest Control in senescent Human Fibroblasts
1083. senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition
1084. Aging and cancer: Cell non-autonomous effects of senescent fibroblasts on tissue microenvironment
1085. Klotho‐mediated targeting of CCL2 suppresses the induction of colorectal cancer progression by stromal cell senescent microenvironments
1086. Hydroxyurea‐induced senescent peripheral blood mesenchymal stromal cells inhibit bystander cell proliferation of JAK2V617F‐positive human erythroleukemia cells
1087. Aging and cancer: Cell non-autonomous effects of senescent fibroblasts on tissue microenvironment
1088. Antibodies to senescent Antigen and C3 Are Not Required for Normal Red Blood Cell Lifespan in a Murine Model
1089. Removing senescent cells from a mixed cell population or tissue using a phosphoinositide 3-kinase (pi3k) inhibitor
1090. Differential Regulation of Methylation-Regulating Enzymes by senescent Stromal Cells Drives Colorectal Cancer Cell Response to DNA-Demethylating Epi-Drugs
1091. senescent Pulmonary-Artery Smooth Muscle Cell (PA-SMC)-Derived Osteopontin Promotes PA-SMC Proliferation in Chronic Obstructive Pulmonary Disease
1092. 303: A role for senescent cell-derived IL6 in HER2+ breast cancer progression
1093. A New LIM Protein Containing an Autoepitope Homologous to ‘senescent Cell Antigen,’
1094. Aging and the senescent cell
1095. Differences between cytotoxicity of chemicals determined in vitro on young and old cells of a senescent cell line
1096. Modulation of Phenotype and Induction of Apoptosis in Vascular Smooth Muscle Cells (VSMC) by Transfer of Human senescent Cell-Derived Inhibitor-1 Gene: 190
1097. Adventitial gene transfer of the antisense to senescent cell-derived inhibitor 1 results in increased neointima
1098. senescent CELL DERIVED INHIBITORS OF DNA SYNTHESIS
1099. Cell cycle and apoptosis: death of a senescent cell
1100. MIMETICS OF senescent CELL DERIVED INHIBITORS OF DNA SYNTHESIS
1101. senescent cell distribution in human skeletal muscle : Role of exercise and protein availability
1102. A new LIM protein containing an autoepitope homologous to’senescent cell antigen’ (vol 201, pg 1127, 1994)
1103. Chemotherapeutics-treated cancer cells display stem-like and senescent cell features
1104. Fisetin is a senotherapeutic that extends health and lifespan
1105. The emerging field of senotherapeutic drugs
1106. SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs.
1107. Src Tyrosine Kinase Inhibitors: New Perspectives on Their Immune, Antiviral, and Senotherapeutic Potential
1108. Senotherapy: growing old and staying young?
1109. Senotherapy for attenuation of cellular senescence in aging and organ implantation
1110. Targeting normal and cancer senescent cells as a strategy of senotherapy
1111. Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)
1112. SASP reflects senescence
1113. SASP mediates chemoresistance and tumor-initiating-activity of mesothelioma cells
1114. Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses
1115. Detection of the senescence-associated secretory phenotype (SASP)
1116. Melatonin regulates PARP 1 to control the senescence‐associated secretory phenotype (SASP) in human fetal lung fibroblast cells
1117. Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2
1118. SASP: tumor suppressor or promoter? Yes!
1119. The experimental demonstration of a SASP-based full software radio receiver
1120. Anti-TNF-α treatment modulates SASP and SASP-related microRNAs in endothelial cells and in circulating angiogenic cells
1121. Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans
1122. Evaluation of the mutagenicity of the anti-inflammatory drug salicylazosulfapyridine (SASP)
1123. Whole Chromosome Instability induces senescence and promotes SASP
1124. SASP gene delivery: a novel antibacterial approach
1125. Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells
1126. The small acid soluble proteins (SASP α and SASP β) of Bacillus weihenstephanensis and Bacillus mycoides group 2 are the most distinct among the Bacillus cereus …
1127. ATM, MacroH2A. 1, and SASP: the checks and balances of cellular senescence
1128. … absorption of 5-aminosalicylic acid (5-ASA) after administration of a 5-ASA enema and salazosulfapyridine (SASP) after an SASP suppository in Japanese volunteers
1129. SASP (Small, Acid-Soluble Spore Proteins) and Spore Properties in Bacillus thuringiensis israelensis and Bacillus sphaericus
1130. Isolation and identification of Lom-SG-SASP, a salivation stimulating peptide from the salivary glands of Locusta migratoria
1131. Targeting the SASP to combat ageing: Mitochondria as possible intracellular allies?
1132. “Social Life” of Senescent Cells: What Is SASP and Why Study It?
1133. Synthesis and characterization of a 29-amino acid residue DNA-binding peptide derived from α/β-type small, acid-soluble spore proteins (SASP) of bacteria
1134. Effects of NAT2 polymorphism on SASP pharmacokinetics in Chinese population
1135. Sensitive detection and monitoring of senescence-associated secretory phenotype by SASP-RAP assay
1136. Another classic of EU sports jurisprudence: Legal implications of Olympique Lyonnais SASP v Olivier Bernard and Newcastle UFC (C-325/08)
1137. Clinical Observation on 30 Cases of Ulcerative Colitis of Damp Heat in the Large Intestine Stagnation Type Treated with Kuijieling Granules Combinated SASP [J]
1138. SASP regulation by noncoding RNA
1139. Scavenger effect of sulphasalazine (SASP), 5-aminosalicylic acid (5-ASA), and olsalazine (OAZ)
1140. SASP, a Senescence-Associated Subtilisin Protease, is involved in reproductive development and determination of silique number in Arabidopsis
1141. Symbol manipulation in FORTRAN: SASP I subroutines
1142. Chronic resveratrol treatment inhibits MRC5 fibroblast SASP-related protumoral effects on melanoma cells
1143. Pharmacokinetics of salazosulfapyridine (Sulfasalazine, SASP)(I): Plasma kinetics and plasma metabolites in the rat after a single intravenous or oral administration
1144. Sirt1 and Parp1 as epigenome safeguards and microRNAs as SASP-associated signals, in cellular senescence and aging
1145. SASP, a Production Planning and Control System for Shipbuilding on Individual Orders
1146. TORn about SASP regulation
1147. Case C-325/08, Olympique Lyonnais SASP v. Olivier Bernard and Newcastle United UFC, Judgment of the Court of Justice (Grand Chamber) of 16 March 2010
1148. Beneficial effect of salazosulfapyridine (SASP) in a patient with secondary renal amyloidosis
1149. Optical design and performance of the SASP spectrometer at TRIUMF
1150. Detecting the senescence-associated secretory phenotype (SASP) by high content microscopy analysis
1151. Pharmacokinetics of Salazosulfapyridine (Sulfasalazine, SASP)(V): Pharmacokinetics of SASP after a single intravenous or oral administration in the dog.
1152. Comparison of SKP (semi-automated kinetic perimetry) and SASP (suprathreshold automated static perimetry) techniques in patients with advanced glaucoma
1153. SIN3B, the SASP, and pancreatic cancer
1154. Pharmacokinetics of Salazosulfapyridine (Sulfasalazine, SASP)(III) Metabolism and biliary excretion of SASP in the rat after a single intravenous or oral administration.
1155. PAI-1 Regulation of TGF-β1-induced ATII Cell Senescence, SASP Secretion, and SASP-mediated Activation of Alveolar Macrophages
1156. Maintenance treatment of ulcerative colitis (UC) with oral 5-aminosalicylic acid (5-ASA) in patients unable to take sulphasalazine (SASP)
1157. Observation of curative effect of Sanguis Draxonis combined with SASP in the treatment of non-specific ulcerative colitis
1158. Replica exchange molecular dynamics simulations of an α/β-type small acid soluble protein (SASP)
1159. 98: Term fetal membranes and senescence associated secretory phenotype (SASP)-like gene expression: a signal for parturition?
1160. COMPARATIVE STUDY OF THE EFFECT OF SULPHASALAZINE (SASP) AND 3 5 DIPS ON GLUTATHIONE (GSH) LEVEL IN RED CELLS OF HUMAN BLOOD IN …
1161. Inhibition of neutral proteases from polymorphonuclear (PMN) neutrophils by salicylazosulfapyridine (SASP)
1162. Senescence-associated secretory phenotype (SASP) involvement in the development of cancer, aging, and age related diseases
1163. RNA-binding Protein Immunoprecipitation (RIP) to examine AUF1 binding to senescence-associated secretory phenotype (SASP) factor mRNA
1164. Modified bacteriophage including an alpha/beta small acid-soluble spore protein (SASP) gene
1165. Modified bacteriophage including an alpha/beta small acid-soluble spore protein (SASP) gene
1166. Arabidopsis subtilase SASP is involved in the regulation of ABA signaling and drought tolerance by interacting with OPEN STOMATA 1
1167. The first experimental demonstration of a SASP-based full Software Radio receiver
1168. A low power digitally-enhanced SASP-based receiver architecture for mobile DVB-S applications in the Ku-band (10.7–12.75 GHz)
1169. Senescence can be BETter without the SASP?
1170. Cancer cell cannibalism and the SASP: Ripples in the murky waters of tumor dormancy
1171. Methyl caffeate and some plant constituents inhibit age-related inflammation: effects on senescence-associated secretory phenotype (SASP) formation
1172. Dissecting cellular senescence and SASP in Drosophila
1173. 169: IL-19, a novel SASP factor, is upregulated during senescence and in response to DSBs
1174. Growth arrest by sulfasalazine (SASP) of subrenal capsule prostate cancer xenografts in immuno-deficient mice is coupled to a decrease in the number of tumor …
1175. COMPARISON OF THE EFFICACY OF 5 ASA AND SASP IN TREATMENT OF ULCERATIVE COLITIS
1176. A La Recherche of Functions for the Spore Protein SASP-E from Bacillus subtilis
1177. SASP: a symbolic algorithm for shortest paths
1178. Molecules and Clusters in Motion: Looking Back and Looking Forward, SASP and Beyond
1179. I no longer dread teaching physics, I now enjoy it!’Participant reflections from the SASP physics course
1180. The salivary gland salivation stimulating peptide from Locusta migratoria (Lom-SG-SASP) is not a typical neuropeptide
1181. Pharmacokinetics of Salazosulfapyridine (Sulfasalazine, SASP)(II) Tissue distribution and excretion of SASP in the rat after a single intravenous or oral administration.
1182. Deciphering the mechanism for induction of senescence-associated secretory phenotype (SASP) and its role in ageing and cancer development
1183. Optimisation of a screening platform for determining IL-6 inflammatory signalling in the senescence-associated secretory phenotype (SASP)
1184. Overexpression of Klotho Inhibits HELF Fibroblasts SASP-related Protumoral Effects on Non-small Cell Lung Cancer Cells
1185. SASP-Dependent Interactions between Senescent Cells and Platelets Modulate Migration and Invasion of Cancer Cells
1186. SKYNET Applications Software Package (SASP) Operators’ and Users’ Handbook, Version 2.
1187. The rehabilitation village-Paper presented at SASP Congress 1993
1188. Designing in uncertainty: The I-SASP model for tactical and innovative risk management in the hi-performing professional practice
1189. Characterization of structural changes in alpha/beta-type small, acid-soluble spore proteins (SASP) upon binding to DNA.
1190. SASP: The future of School Psychology
1191. Regulation of the senescence-associated secretory phenotype (SASP)
1192. Micromanaging fibroblast senescence: The role of small non-coding RNAs in senescence associated secretory phenotype (SASP)
1193. Effect of sulfasalazine (SASP) on sodium flux in rat colon
1194. Senescence utilises inflammatory caspases to drive SASP
1195. Outcome of Patients with Ankylosing Spondyloarthritis Continuing Treated with Thalidomide and SASP after a Short Course of Etanercept Therapy [J]
1196. Study on Effect of Regulation to Th1/Th2 in AUC Patients with Chinese Medicine Combined with SASP Enema under Guidance of Synchronous Treatment of Lung …
1197. Effect of combine probiotics with SASP on inflammatory bowel disease
1198. Changes of T regulatory cells in rats with experimental colitis after drug treatment with SASP and PSL
1199. Clinical effects of 99Tc-2MDP combined with SASP for ankylosing spondylitis
1200. Ex-SASP-erating cancer
1201. ETDEWEB/Search Results/Proceedings of the DASS/SASP (Dual Arm Spectrometer System/Second Arm Spectrometer) workshop
1202. Immunological Responses and Protection in Dairy Cows Vaccinated with Staphylococcus aureus Surface Proteins (SASP) and Staphylococcus chromogenes …
1203. Studies on the Role of SASP in Heat and Radiation Resistance of Bacterial Spores and on Regulation of a SASP Specific Protease
1204. Scavenger effect of sulphasalazine (SASP)
1205. SASP: targeted delivery to Gram-negative pathogens
1206. Slow-Release 5-Aminosalicylic Acid (Pentasa) versus Sulphasalazine (SASP) in the Maintenance Treatment of Ulcerative Colitis (82)
1207. SKYNET Applications Software Package (SASP) Programmers’ Handbook, Version 2.
1208. Signatures analysis systems prototype (SASP)
1209. PAI-1-Stimulated AT2 Cell SASP Promotes Profibrotic Polarization of Alveolar Macrophages
1210. … serum antibodies to bacterial antigens may be used as markers for the likelihood of response to SASP could have implications regarding the tailoring of SASP …
1211. Advances in pain management and research presented at the 2015 Scientific Meeting of the Scandinavian Association for the Study of Pain (SASP)
1212. SASP-A digital signal processor system for speech processing applications
1213. Poster-abstracts from SASP–The Scandinavian Association for the Study of Pain scientific meeting, Oslo, Norway, April 7–9, 2014
1214. The salivary gland salivation stimulating peptide from Locusta migratoria (Lom-SG-SASP) is not a neuropeptide
1215. Poor attendance at the SASP annual meeting
1216. … OF SOLUBLE TAU AGGREGATES IN BRAIN MICROVASCULAR ENDOTHELIAL CELLS PROMOTES CELLULAR SENESCENCE/SASP AND BLOCKS ENOS …
1217. Senescence-Associated Secretory Pheno-type (SASP)
1218. Provisional programme for SASP congress
1219. THE MANIPULATIVE THERAPISTS’GROUP OF THE SASP
1220. Algorithms for arithmetic operation in a systolic array of single-bit processor (SASP)
1221. SASP Erwin Schrödinger Gold Medal 2010
1222. Lipid metabolism is involved in mitotic slippage-induced SASP upon treatment with anti-mitotic drugs
1223. The role of SASP in tumor microenvironment.
1224. Effection of Tripterygium Wilfordii Unions SASP Moves to Rheumatoid Arthritis [J]
1225. Prospects for (p, pi) physics in the Delta region using the SASP spectrometer
1226. Scientific presentations at the 2017 annual meeting of the Scandinavian Association for the Study of Pain (SASP)
1227. Assessing Functional Roles of the Senescence-Associated Secretory Phenotype (SASP)
1228. Report of first AGM of obstetric group of SASP
1229. Conceptual design study Science and Application Space Platform SASP. Volume 1: Executive summary
1230. Pharmacokinetics of Salazosulfapyridine (Sulfasalazine, SASP)(IV): Pharmacokinetics of SASP in the rat following consecutive oral doses.
1231. Treating 150 Cases with Active Ankylosing Spondylitis with Chinese Peashrub Root Powder Capsule combined with SASP
1232. TOE MANIPULATIVE THERAPISTS’GROUP OF THE SASP
1233. … of long term radionuclide data for lead-210 and beryllium-7 collected at Murdoch University for the Surface Air Sampling Program (SASP) of the Environmental …
1234. Human SLE bone marrow mesenchymal stem cells (BMSCs) have a senescence-associated secretory phenotype (SASP) mediated by a MAVS-IFNβ …
1235. Secondary amine selective Petasis (SASP) bioconjugation
1236. The senescence-associated secretory phenotype (SASP) from mesenchymal stromal cells impairs growth of immortalized prostate cells but has no effect on …
1237. Convergent validity of the Richmond Reversal Rating in relation to visual-spatial perception as measured by the SASP
1238. In Search of Nutritional Anti-Aging Targets: TOR Inhibitors, SASP Modulators And BCL-2 Family Suppressors
1239. Non-overlapping roles of the RP and p19Arf pathways in protecting oncogenic induced HCC and their roles to modulate SASP
1240. XXth Symposium on Atomic, Cluster and Surface Physics 2016 (SASP 2016)
1241. Hep:: HepNames:: Institutions:: Conferences:: Jobs:: Experiments:: Journals:: Help Home> Conferences> DASS/SASP (Dual Arm Spectrometer System …
1242. 14 ANALYSIS OF SASP REFERENCES: INSIGHTS FOR EFFECTIVE CONTINUING MEDICAL EDUCATION FOR UROLOGISTS
1243. Correction to: Optimisation of a screening platform for determining IL-6 inflammatory signalling in the senescence-associated secretory phenotype (SASP)
1244. Brief Overview of the ECJ Judgement in the Case of Olympique Lyonais SASP v. Olivier Bernard and Newcastle United Football Club
1245. The Senescence-Associated Secretory Phenotype (SASP) and Redox-Dependent Invasion of Metastatic Cancer Cells
1246. PO-112 The senescence associated secretory phenotype (SASP)-factor ccl2 fosters vascular dysfunction and endothelial cell loss in radiation-induced lung disease
1247. Efficacy of artemisinin and SASP on chicken coccidiosis induced by Eimeria tenella.
1248. AISA can control the inflammatory facet of SASP
1249. Momentum Calibration for the SASP Spectrometer
1250. … Article Folic Acid Supplementation Suppresses Sleep Deprivation-Induced Telomere Dysfunction and Senescence-Associated Secretory Phenotype (SASP)
1251. Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase
1252. SASP. Contributions to the 13. Symposium on atomic and surface physics and related topics
1253. Folic Acid Supplementation Suppresses Sleep Deprivation-Induced Telomere Dysfunction and Senescence-Associated Secretory Phenotype (SASP)
1254. SKYNET Applications Software Package (SASP) Operator’s and User’s Handbook.
1255. Unmasking senescence: context-dependent effects of SASP in cancer
1256. VOLUME II-TECHNICAL REPORT PART A SASP SPECIAL EMPHASIS TRADE STUDIES’k
1257. Sexual Assault Services Program (SASP) and Sexual Offense Services (SOS)
1258. Review of Best Practices for ICJI Program Areas: Sexual Assault Services Program (SASP) and Sexual Offense Services (SOS)
1259. Chronic resveratrol treatment inhibits MRC5 fibroblast SASP-related pro-tumoral effects on melanoma cells
1260. P10 CELL SURFACE INTERLEUKIN-1α, WHICH DRIVES THE SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP), IS TETHERED VIA IL …
1261. The annual meeting of the Scandinavian Association for the Study of Pain (SASP) 18-20 April 2018− S1
1262. Science and Applications Space Platform (SASP) End-to-End Data System Study
1263. … Responses and Protection in Dairy Cows Vaccinated withStaphylococcus aureusSurface Proteins (SASP) andStaphylococcus chromogenes Surface Proteins …
1264. … /REPERFUSION (I/R) INDUCED INFLAMMAGING BY INHIBITING SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP) IN TUBULAR EPITHELIAL …
1265. SASP-Symposium on atomic, cluster and surface physics’ 94
1266. The Triumf Second Arm Spectrometer System (SASP)
1267. Proceedings of the DASS/SASP (Dual Arm Spectrometer System/Second Arm Spectrometer) Workshop, Vancouver, March 17-18, 1986
1268. The Abstracts of SASP 2001: The Seventh Annual Meeting of the Society of Australasian Social Psychologists
1269. SASP’86: Symposium on atomic and surface physics
1270. 1‐Amino‐2‐(Silyloxymethyl) Pyrrolidines (SASP)
1271. Address at the opening Jubilee Congress of the SASP by the Minister of Health and Welfare
1272. SASP. Symposium on atomic and surface physics’ 82. Contributions

[HTML] Senolytics: A Translational Bridge Between Cellular Senescence and Organismal Aging

H Thoppil, K Riabowol – Frontiers in Cell and Developmental Biology, 2019
… Huang et al., 1999; Montero et al., 2011). These compounds form one of the first discovered members of the senolytic class of drugs that selectively induce apoptosis in senescent cells. Four years after their initial identification as …

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BIOMARKERS FOR CELLULAR SENESCENCE

M Demaria – US Patent App. 16/492,410, 2020
… 15. The drug conjugate according to claim 12, wherein the cytotoxic agent is a senolytic agent, a radioisotope, a toxin or a toxic peptide. 16 … The cytotoxic agent can be a radioisotope, a toxin, toxic peptide or a senolytic drug …

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[HTML] Potential Role of Cellular Senescence in Asthma

ZN Wang, RN Su, BY Yang, KX Yang, LF Yang, Y Yan… – Frontiers in Cell and …, 2020
… proteases expressed by senescent lung fibroblasts could result in low-level inflammation and fibrosis (Schafer et al., 2017; Álvarez et al., 2017). Clearance of these senescent fibroblasts by senolytic drugs would render the reso.

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The Heterogeneity of Senescent Cells

LITO Salon
… However, there is no single senolytic that has been shown to target all of our senescent cells … One example is Cleara Biotechnologies, whose founder, Dr. Peter De Keizer, has talked about senolytic “cocktails” and the problem …

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Perspectives of the potential implications of polyphenols in influencing the interrelationship between oxi-inflammatory stress, cellular senescence and …

R Sharma, Y Padwad – Trends in Food Science & Technology, 2020
JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page. Skip to main content Skip to article …

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[PDF] Special issue on “Molecular genetics of aging and longevity”: a critical time in the field of geroscience

BA Benayoun, RA Veitia
… aging. From the perspective of precision medicine, it will be possible to identify individu- als at higher risk of developing single or multiple morbidi- ties for devising new preventive measures, such as specific senolytic treatments …

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Pharmacotherapy to gene editing: potential therapeutic approaches for Hutchinson–Gilford progeria syndrome

S Saxena, S Kumar – GeroScience
… 2017). Senescent cells also upregulate the expression of anti-apoptotic proteins BCL-W and BCL-XL, the inhibition of which with siRNA or small molecules ABT-737 or ABT-263 (senolytic drugs) leads to apoptosis (Chang …

[PDF] Establishment of a Temperature-Sensitive Model of Oncogene-Induced Senescence in Angiosarcoma Cells

A Costa, MY Bonner, S Rao, L Gilbert, M Sasaki… – Cancers, 2020
… the nonpermissive temperature. This suggests that the maintenance of the senescent phenotype results in a low level of p38 signaling and that p38 activators might be effective in mediating senolytic therapies. Consistent with …

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Cancer as a disease of old age: changing mutational and microenvironmental landscapes

E Laconi, F Marongiu, J DeGregori – British Journal of Cancer, 2020
Why do we get cancer mostly when we are old? According to current paradigms, the answer is simple: mutations accumulate in our tissues throughout life, and some of these mutations contribute to cancers.

Preadipocyte secretory factors differentially modulate murine macrophage functions during aging which are reversed by the application of phytochemical EGCG

R Kumar, A Sharma, Y Padwad, R Sharma – Biogerontology
… Working on green tea EGCG, we have previously reported its anti- immunosenescence, anti-inflammatory, anti-senescence, senolytic and synbiotic attributes thereby suggesting its multi-faceted potency as an …

[PDF] Novel properties of mature adipocytes in obesity and hyperinsulinemia

Q Li – 2020
Page 1. From the Department of Cell and Molecular Biology Karolinska Institutet, Stockholm, Sweden Novel properties of mature adipocytes in obesity and hyperinsulinemia Qian Li 李 倩 Stockholm 2020 Page 2. Cover picture …

[PDF] Establishment of a Temperature-Sensitive Model of Oncogene-Induced Senescence in Angiosarcoma Cells

A Costa, MY Bonner, S Rao, L Gilbert, M Sasaki… – Cancers, 2020
… the nonpermissive temperature. This suggests that the maintenance of the senescent phenotype results in a low level of p38 signaling and that p38 activators might be effective in mediating senolytic therapies. Consistent with …

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Cancer as a disease of old age: changing mutational and microenvironmental landscapes

E Laconi, F Marongiu, J DeGregori – British Journal of Cancer, 2020
Why do we get cancer mostly when we are old? According to current paradigms, the answer is simple: mutations accumulate in our tissues throughout life, and some of these mutations contribute to cancers. Although …

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Preadipocyte secretory factors differentially modulate murine macrophage functions during aging which are reversed by the application of phytochemical EGCG

R Kumar, A Sharma, Y Padwad, R Sharma – Biogerontology
… Working on green tea EGCG, we have previously reported its anti- immunosenescence, anti-inflammatory, anti-senescence, senolytic and synbiotic attributes thereby suggesting its multi-faceted potency as an …

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[PDF] Novel properties of mature adipocytes in obesity and hyperinsulinemia

Q Li – 2020
Page 1. From the Department of Cell and Molecular Biology Karolinska Institutet, Stockholm, Sweden Novel properties of mature adipocytes in obesity and hyperinsulinemia Qian Li 李 倩 Stockholm 2020 Page 2. Cover picture …

Targeted reduction of senescent cell burden alleviates focal radiotherapy-related bone loss.

A Chandra, AB Lagnado, JN Farr, DG Monroe, S Park… – Journal of bone and mineral …, 2020
… To test if senolytic drugs, which clear senescent cells, alleviate FRT-related bone damage, we administered the senolytic agents, Dasatinib (D), Quercetin (Q), Fisetin (F), and a cocktail of D and Q (D+Q). We found moderate …

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Treating cognitive decline and other neurodegenerative conditions by selectively removing senescent cells from neurological tissue

RM Laberge, J Campisi, M Demaria, N David… – US Patent App. 16/584,638, 2020
… US 20200030323 A1 US20200030323 A1 US 20200030323A1 US 201916584638 A US201916584638 A US 201916584638A US 2020030323 A1 US2020030323 A1 US 2020030323A1 Authority US United States Prior …

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[HTML] Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis

T Montero-Melendez, A Nagano, C Chelala, A Filer… – Nature Communications, 2020
Rheumatoid arthritis affects individuals commonly during the most productive years of adulthood. Poor response rates and high costs associated with treatment mandate the search for new therapies. Here we show that targeting a specific …

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[HTML] SENEBLOC, a long non-coding RNA suppresses senescence via p53-dependent and independent mechanisms

CL Xu, B Sang, GZ Liu, JM Li, XD Zhang, LX Liu… – Nucleic Acids Research, 2020
… Moreover, SENEBLOC was shown to be involved in both oncogenic and replicative senes- cence, and from the perspective of senolytic agents we show that the antagonistic actions of rapamycin on senescence are dependent on SENEBLOC ex- pression …

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Repurposing cell penetrating peptides and their novel derivatives and iopromide and iodo-aryl carbonates for treatment of senescence-related diseases and disorders

SS Çinarouglu, E Timucin, GB Akcapinar, U Sezerman… – US Patent App. 16/526,997, 2020
… US2020031873A1 US 20200031873 A1 US20200031873 A1 US 20200031873A1 US 201916526997 A US201916526997 A US 201916526997A US 2020031873 A1 US2020031873 A1 US 2020031873A1 …

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[HTML] Implications of Oxidative Stress and Cellular Senescence in Age-Related Thymus Involution

A Barbouti, PVS Vasileiou, K Evangelou, KG Vlasis… – Oxidative Medicine and …, 2020

The human thymus is a primary lymphoepithelial organ which supports the production of self-tolerant T cells with competent and regulatory functions. Paradoxically, despite the crucial role that it exerts in T cell-mediated immunity …

[HTML] Taking in consideration the bystander effects of articular senescence

JM Brondello, YM Pers – Annals of Translational Medicine, 2019
… harboring shorten telomeres, by accumulating cycle-dependent kinases inhibitors driving senescence such as p16 Ink4a , p21 Cdkn1A and p57 KIP2 , and finally by producing deleterious catabolic and inflammatory mediators …

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RNA Biology Provides New Therapeutic Targets for Human

LW Harries – Role of RNA Modification in Disease, 2020
… For example, strategies are emerging now which allow selective delivery of senolytic cargoes to senescent cells only using galactosaccharide nanoparticles, which harness the observation that senescent cells harbor …

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The ageing epigenome and its rejuvenation

W Zhang, J Qu, GH Liu, JCI Belmonte – Nature Reviews Molecular Cell Biology, 2020

Ageing is characterized by the functional decline of tissues and organs and the increased risk of ageing-associated disorders. Several ‘rejuvenating’ interventions have been proposed to delay ageing and the onset of …

[PDF] Beyond Tumor Suppression: Senescence in Cancer Stemness and Tumor Dormancy

F Triana-Martínez, MI Loza, E Domínguez – Cells, 2020
… with the promise of future directions on innovative anticancer therapies. Keywords: cellular senescence; stemness; dormancy; quiescence; senolytic 1. Introduction Natural tumor evolution is a complex process, composed of …

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The Heterogeneity of Senescent Cells

NK September
… However, there is no single senolytic that has been shown to target all of our senescent cells … One example is Cleara Biotechnologies, whose founder, Dr. Peter De Keizer, has talked about senolytic “cocktails” and the problem …

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[PDF] Regorafenib Alteration of the BCL-xL/MCL-1 Ratio Provides a Therapeutic Opportunity for BH3-Mimetics in Hepatocellular Carcinoma Models

B Cucarull, A Tutusaus, M Subías, M Stefanovic… – Cancers, 2020
… A-1331852 has been proposed as an agent in cancer therapy [42,43] and, more recently, as a senolytic compound [44]. Interestingly, through a dual mechanism acting on senescent cholangiocytes and activated fibroblasts …

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Cellular Senescence and Tumor Promotion

M Demaria – Geriatric Oncology
… rejuvenation of aged-tissue stem cells (Childs et al. 2017; Soto- Gamez and Demaria 2017). Currently, a limited number of senolytic agents have been identified. 2-DG, a false substrate for the glycolytic metabolism, or bafilomycin A1, a

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[PDF] Henry Ford Health System Scholarly Common s

DE Citrin, PGS Prasanna, AJ Walker, ML Freeman…
… this setting. Although preventing premature senescence has shown promise in preventing RIF, there is increasing interest in agents that can clear prematurely senescent cells from tissues using “senolytic” drugs. Indeed, clearance …

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The role of adipose tissue senescence in obesity-and ageing-related metabolic disorders

Z Liu, KKL Wu, X Jiang, A Xu, KKY Cheng – Clinical Science, 2020

Skip to Main Content …

[PDF] Stress-induced Cellular Senescence Contributes to Chronic Inflammation and Cancer Progression

S KOBASHIGAWA, YM SAKAGUCHI, S MASUNAGA… – Thermal Medicine, 2019
… In addition, a recent study demonstrated the efficacy of senolytic drugs in the selective elimination of senescent cells123); a combined treatment of dasatinib and quercetin (D＋Q) was found to reduce the number of senescent …

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[PDF] Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice

MJ Yousefzadeh, J Zhao, C Bukata, EA Wade… – Aging Cell
Abstract Senescent cells accumulate with age in vertebrates and promote aging largely through their senescence‐associated secretory phenotype (SASP). Many types of stress induce senescence, includi…

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Cardiac Glycosides as Senolytic Compounds

N Martin, O Soriani, D Bernard – Trends in Molecular Medicine, 2020
The identification of senolytics, compounds that eliminate senescent cells, is presently a key priority given their therapeutic promise in cancer and aging-associated diseases. Two recent papers by Triana-Martínez et al. and Guerrero et al …

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[HTML] Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype

AJ Barinda, K Ikeda, DB Nugroho, DA Wardhana… – Nature Communications, 2020
Vascular senescence is thought to play a crucial role in an ageing-associated decline of organ functions; however, whether vascular senescence is causally implicated in age-related disease remains unclear. Here we show that …

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[HTML] Urogenital Support

BI Blog, ADN Booster
… Current research has shown that certain plant polyphenols (ie quercetin and fisetin) are strong senolytic agents (molecules that stop senescence), and have exciting potential for reducing and preventing senescence, which …

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[PDF] Transplanting cells from old but not young donors causes physical dysfunction in older recipients

B Wang, Z Liu, VP Chen, L Wang, CL Inman, Y Zhou… – Aging Cell
… Our study potentially begins new avenues of research to discover whether pharmacological interventions, such as senolytic drugs (Tchkonia & Kirkland, 2018) or anti‐inflammatory drugs, can prevent or reverse dysfunction caused …

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[PDF] Preclinical Pharmacological Activities of Epigallocatechin-3-gallate in Signaling Pathways: An Update on Cancer

M Sharifi-Rad, R Pezzani, M Redaelli, M Zorzan… – Molecules, 2020
Page 1. Molecules 2020, 25, 467; doi:10.3390/molecules25030467 www.mdpi.com/ journal/molecules Review Preclinical Pharmacological Activities of Epigallocatechin- 3-gallate in Signaling Pathways: An Update on Cancer

Senolytic compositions and uses thereof

MA Gallop, J Klein, M Quarta – US Patent App. 16/508,477, 2020
UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound data: image/svg+xml; base64, PD94bWwgdmVyc2lvbj0nMS4wJyBlbm…/+ IDwvcmVjdD4KPHBhdGggY2xhc3M9J2…+Cjx0ZXh0IHg9JzIyOS45MjQnIHk9JzE1… PHRzcGFuPkg8L3RzcGFuPjwvdGV4d …

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Impaired Myofibroblast Dedifferentiation Contributes to Non-Resolving Fibrosis in Aging

K Kato, NJ Logsdon, YJ Shin, S Palumbo, A Knox… – American Journal of …, 2020
… One study demonstrated that the senolytic agent, quercetin, restored apoptosis susceptibility in IPF lung myofibroblasts, and inhibited fibrotic responses to lung injury in aged mice (62). Further, the first-in-human pilot study with a senolytic …

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[HTML] Browsed by Tag: Mitochondrial mutations

N Bagalà, S Hill

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[PDF] Cellular senescence contributes to age‐dependent changes in circulating extracellular vesicle cargo and function

FJ Alibhai, F Lim, A Yeganeh, PV DiStefano… – Aging Cell
… Instead, we show that cellular senescence contributes to changes in particle cargo and function. Notably, senolytictreatment of old mice shifted plasma particle cargo and function toward that of a younger phenotype.

Therapy-induced senescence—an induced synthetic lethality in liver cancer?

K Wolter, L Zender – Nature Reviews Gastroenterology & Hepatology, 2020
… cells. Therefore, the directed use of senolytic therapies in human cancers necessitates imaging modalities to non-invasively visualize TIS, thereby enabling image-guidedapplications of senolytic therapies. Full size image. Two …

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Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice.

MB Cavalcante, TD Saccon, ADC Nunes, JL Kirkland… – Aging, 2020
… Collagen deposition in the uterus is related to uterine aging. Senolytic therapies are an option for reducing health complications related to aging. We investigated effects of agingand the senolytic drug combination of dasatinib plus quercetin (D+Q) on uterine fibrosis …

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[HTML] CMV-independent increase in CD27− CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians

C Martin-Ruiz, J Hoffmann, E Shmeleva, T von Zglinicki… – npj Aging and Mechanisms …, 2020
… p < 0.001; **p < 0.01; *p < 0.05 using 1-way ANOVA. Full size image. Senolytic therapy … The gating scheme is depicted in Fig. 2a. Animals, procedures and senolytictreatment. C57BL/6 mice were analyzed at either …

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Dasatinib, a second-generation tyrosine kinase inhibitor, induces melanogenesis via ERK-CREB-MITF-tyrosinase signaling in normal human melanocytes

B Kang, Y Kim, TJ Park, HY Kang – Biochemical and Biophysical Research …, 2020
… allergic asthma. Br. J. Pharmacol., 173 (2016), pp. 1236-1247. Google Scholar. [8] JL Kirkland, T. Tchkonia, Y. Zhu, LJ Niedernhofer, PD RobbinsThe clinical potential of senolytic drugs. J. Am. Geriatr. Soc., 65 (2017), pp. 2297 …

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[PDF] The role of the microbiota in sedentary life style disorders and ageing: Lessons from the animal kingdom

PW O’Toole, PG Shiels – Journal of Internal Medicine, 2020
… Nrf2 regulates over 390 stress defence genes linked to longevity and health span. Moreover, alkyl catechols comprise a group of chemicals that include the senolytic agents fisetin and quercetin, which have proven efficacy in …

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[HTML] Browsed by Tag: cancer

G Stolyarov II, A Grases
… When I am 85, the senolytic DNA machinery will be far from the only addition to my cells … Inflammatory conditions of aging will be a shadow of what they once were, because of senolytic therapies presently under development …

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Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation–induced impairment of neurovascular coupling responses protecting …

A Yabluchanskiy, S Tarantini, P Balasubramanian… – GeroScience
… Data are expressed as mean ± SEM. Results. WBI induces astrocyte senescence: protective effects of senolytictreatments … 3d, e). WBI impairs eicosanoid gliotransmitter-mediated NVC responses: protective effects of senolytictreatments …

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[HTML] Astrocyte Support for Oligodendrocyte Differentiation can be Conveyed via Extracellular Vesicles but Diminishes with Age

CM Willis, AM Nicaise, ER Bongarzone, M Givogri… – Scientific Reports, 2020
The aging brain is associated with significant changes in physiology that alter the tissue microenvironment of the central nervous system (CNS). In the aged CNS, increased demyelination has been associated with astrocyte hypertrophy …

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[HTML] TGF-β1/IL-11/MEK/ERK signaling mediates senescence-associated pulmonary fibrosis in a stress-induced premature senescence model of Bmi-1 deficiency

H Chen, H Chen, J Liang, X Gu, J Zhou, C Xie, X Lv… – Experimental & Molecular …, 2020
To study whether TGF-β1/IL-11/MEK/ERK (TIME) signaling mediates senescence-associated pulmonary fibrosis (SAPF) in Bmi-1-deficient (Bmi-1−/−) mice and determines the major downstream mediator of Bmi-1 …

[HTML] Underlying Histopathology Determines Response to Oxidative Stress in Cultured Human Primary Proximal Tubular Epithelial Cells

MA Khan, X Wang, KTK Giuliani, P Nag, A Grivei… – International Journal of …, 2020
Proximal tubular epithelial cells (PTEC) are key players in the progression of kidney diseases. PTEC studies to date have primarily used mouse models and transformed human PTEC lines. However, the translatability of these …

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[HTML] Metabolic Syndrome Support

BI Blog, HIA You
… Current research has shown that certain plant polyphenols (ie quercetin and fisetin) are strong senolytic agents (molecules that stop senescence), and have exciting potential for reducing and preventing senescence, which …

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PDF] Senescent Colon and Breast Cancer Cells Induced by Doxorubicin Exhibit Enhanced Sensitivity to Curcumin, Caffeine, and Thymoquinone

AH El-Far, NHE Darwish, SA Mousa – Integrative Cancer Therapies, 2020
Cellular senescence is a process of physiological growth arrest that can be induced by intrinsic or extrinsic stress signals. Some cancer therapies are associated with senescence of cancer cells wi…

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Targeting defective pulmonary innate immunity–A new therapeutic option?

KBR Belchamber, LE Donnelly – Pharmacology & Therapeutics, 2020

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Targeting the progression of chronic kidney disease

M Ruiz-Ortega, S Rayego-Mateos, S Lamas, A Ortiz… – Nature Reviews Nephrology, 2020
Chronic kidney disease (CKD) is a devastating condition that is reaching epidemic levels owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well as ageing of the population. Regardless …

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Cellular senescence: from anti-cancer weapon to anti-aging target

L Yuan, PB Alexander, XF Wang – Science China Life Sciences, 2020
Cellular senescence (CS) is a state of stable cell cycle arrest characterized by the production and secretion of inflammatory molecules. Early studies desc.

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[PDF] Targeting Age-Related Pathways in Heart Failure

H Li, MH Hastings, J Rhee, LE Trager, JD Roh… – Circulation Research, 2020
During aging, deterioration in cardiac structure and function leads to increased susceptibility to heart failure. The need for interventions to combat this age-related cardiac decline is becoming i…

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[HTML] Autophagy Reprograms Alveolar Progenitor Cell Metabolism in Response to Lung Injury

X Li, J Wu, X Sun, Q Wu, Y Li, K Li, Q Zhang, Y Li… – Stem Cell Reports, 2020
JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page. Skip to main content Skip to article …

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[HTML] A Newly Synthesized Rhamnoside Derivative Alleviates Alzheimer’s Amyloid-β-Induced Oxidative Stress, Mitochondrial Dysfunction, and Cell Senescence through …

Y Li, J Lu, X Cao, H Zhao, L Gao, P Xia, G Pei – Oxidative Medicine and Cellular …, 2020
Oxidative stress-induced mitochondrial dysfunction and cell senescence are considered critical contributors to Alzheimer’s disease (AD), and oxidant/antioxidant imbalance has been a therapeutic target in AD. SIRT3 …

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