Telomere Shortening & Premature Aging

Telomeres, the caps on our chromosomes, shorten with each cell division. This shortening acts like a cellular clock, and critically short telomeres are linked to premature aging and a higher risk of age-related diseases. Research suggests telomere dysfunction can trigger cellular senescence, a state where cells stop dividing but linger, potentially harming surrounding tissues. This buildup of senescent cells is associated with various conditions like heart disease, Alzheimer’s, and even some cancers. While telomere shortening is a natural part of aging, understanding its role in cellular health is crucial for developing strategies to combat age-related decline and promote healthy longevity.

A branching process model of telomere shortening
A continuous correlation between oxidative stress and telomere shortening in fibroblasts
A Critical Role for Pin2/TRF1 in ATM-dependent Regulation
INHIBITION OF Pin2/TRF1 FUNCTION COMPLEMENTS telomere shortening, RADIOSENSITIVITY, AND THE G2/M CHECKPOINT DEFECT OF ATAXIA-TELANGIECTASIA CELLS
A G-quadruplex-interactive agent, telomestatin (SOT-095), induces telomere shortening with apoptosis and enhances chemosensitivity in acute myeloid leukemia
A Home Use Study in Healthy Volunteers to Assess Effectiveness of a Dietary Supplement to Halt the Shortening of telomere Length as Demonstrated by the “ …
A kinetic model of telomere shortening in infants and adults
A protein array screen for Kaposi’s sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening
A randomized-controlled clinical study of Telos95®, a novel antioxidative dietary supplement, on the shortening of telomere length in healthy volunteers
A stochastic model of cell replicative senescence based on telomere shortening, oxidative stress, and somatic mutations in nuclear and mitochondrial DNA
A tel2 Mutation That Destabilizes the Tel2-Tti1-Tti2 Complex Eliminates Rad3ATR Kinase Signaling in the DNA Replication Checkpoint and Leads to telomere shortening in Fission Yeast
A TIN2 dyskeratosis congenita mutation causes telomerase-independent telomere shortening in mice
A15812 Angiotensin Converting Enzyme Inhibitors Epigenetically Atenuate telomere shortening
A7. 9 Does telomere shortening in Women with Rheumatoid Arthritis Predict X Chromosome Inactivation Bias?
AB181. telomere shortening is associated with genetic anticipation in Chinese Von Hippel-Lindau disease families
Abnormal telomere shortening in leucocytes of children with Shwachman–Diamond syndrome
Abnormal telomere shortening of peripheral blood mononuclear cells and granulocytes in patients with chronic idiopathic neutropenia
Abrogation of miR-195 Improves Function in Aged Heart by Preventing telomere shortening and Mitochondrial Dysfunction
Abrupt telomere shortening in cell aging and cancer
Abrupt telomere shortening in normal human fibroblasts
Absence of telomere shortening and oxidative DNA damage in the young adult offspring of women with pre-gestational type 1 diabetes
Abstract A63: Rsf-1, a chromatin remodeling protein, interacts with shelterin protein hRap1 and induces telomere shortening
Abstract# 3036: telomere length shortening in individuals with sporadic compared with familial breast cancer
Abstract# 3482: telomere shortening in human tumor cells in vitro and in vivo following treatment with telomerase inhibitor, GRN163L
Abstract# 4505: Peripheral telomere shortening is most closely associated with young age of onset for pancreatic cancer
Abstract# 5139: The inflammatory cytokine TNF-\# 945; induces rapid, reversible telomere shortening in breast cancer cell lines
Accelerated aging as evidenced by increased telomere shortening and mitochondrial DNA depletion in patients with type 2 diabetes
Accelerated telomere length shortening in granulocytes: a diagnostic marker for myeloproliferative diseases
Accelerated telomere shortening and replicative senescence in human fibroblasts overexpressing mutant and wild-type lamin A
Accelerated telomere shortening and senescence in human pancreatic islet cells stimulated to divide in vitro
Accelerated telomere shortening and telomerase activation in Fanconi’s anaemia
Accelerated telomere shortening and telomere abnormalities in radiosensitive cell lines
Accelerated telomere shortening following allogeneic transplantation is independent of the cell source and occurs within the first year post transplant
Accelerated telomere shortening in acromegaly; IGF-I induces telomere shortening and cellular senescence
Accelerated telomere shortening in ataxia telangiectasia
Accelerated telomere shortening in bonemarrow recipients
Accelerated telomere shortening in CD8+ T-lymphocytes From Patients With Coronary Heart Disease Links Cytomegalovirus-Induced T Cell Response and …
Accelerated telomere shortening in Fanconi anemia fibroblasts–a longitudinal study
Accelerated telomere shortening in fibroblasts after extended periods of confluency
Accelerated telomere shortening in peripheral blood lymphocytes after occupational polychlorinated biphenyls exposure
Accelerated telomere shortening in Response to Air Pollution from Traffic Emissions.
Accelerated telomere shortening in response to life stress
Accelerated telomere shortening in rheumatic diseases: cause or consequence?
Accelerated telomere shortening in the human inactive X chromosome
Accelerated telomere shortening in young recipients of allogeneic bone-marrow transplants
Accelerated telomere shortening in β-thalassemia/HbE patients
Accelerated telomere shortening precedes development of therapy-related myelodysplasia or acute myelogenous leukemia after autologous transplantation …
Accelerated telomere shortening: Tracking the lasting impact of early institutional care at the cellular level
Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts
Advanced telomere shortening in respiratory chain disorders
Age estimation in dental pulp DNA based on human telomere shortening
Age-associated telomere shortening in mouse oocytes
Age-associated telomere shortening in Thoroughbred horses
Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress
Age‐dependent telomere‐shortening is repressed by phosphorylated α‐tocopherol together with cellular longevity and intracellular oxidative‐stress reduction in …
Age-independent telomere shortening and ion-channel defects in SCD
Ageing and telomeres: a study into organ‐and gender‐specific telomere shortening
Age-related telomere shortening occurs in lens epithelium from old rats and is slowed by caloric restriction
Age-related telomere uncapping is associated with cellular senescence and inflammation independent of telomere shortening in human arteries
Age-Related telomere Uncapping Occurs Independent of telomere shortening in Mouse Endothelial Cells
Aging-related telomere shortening and cognitive decline in the Betula study: No evidence of coupled changes
Alpha-tocopherol modulates hydrogen peroxide-induced DNA damage and telomere shortening of human skin fibroblasts derived from differently aged individuals
Amplification of the human epidermal growth factor receptor 2 gene in differentiated thyroid cancer correlates with telomere shortening
An association between telomere shortening and disease evolution patterns in MDS
An investigation on mitochondrial DNA deletions and telomere shortening during multiple passages of adult stem cells
An Isogenic Trisomic–Disomic Model System Using Cells from People with Mosaic Down Syndrome Unmasks Trisomy 21 Associated Increases in Age-Related Chromosomal Instability, Senescence Associated Distension of Satellites, and telomere shortening
Analysis of the telomere shortening in the cloned caprine cultured cell line, CPF-1, derived from placenta of Shiba goat (Capra hircus)
Ancestral telomere shortening: A countdown that will increase mean life span?
Angiotensin II type 1 receptor gene polymorphism and telomere shortening in essential hypertension
Antisense oligonucleotide-mediated inhibition of hTERT, but not hTERC, induces rapid cell growth decline and apoptosis in the absence of telomere shortening in human prostate cancer cells
Artemisinin mimics calorie restriction to initiate antioxidative responses and compromise telomere shortening
Artemisinin mimics calorie restriction to trigger mitochondrial biogenesis and compromise telomere shortening in mice
Artificial light at night does not affect telomere shortening in a developing free-living songbird: A field experiment: Artificial light at night and telomere dynamics
Asp-Ala-His-Lys (DAHK) inhibits copper-induced oxidative DNA double strand breaks and telomere shortening
Association between antidiabetic agents use and leukocyte telomere shortening rates in patients with type 2 diabetes
Association between leukocyte telomere shortening and exposure to traffic pollution: a cross-sectional study on traffic officers and indoor office workers
Association between oxidative DNA damage and telomere shortening in circulating endothelial progenitor cells obtained from metabolic syndrome patients with …
Association between telomere shortening and ageing during occupational exposure
Association of Immune Abnormalities with telomere shortening in
Association of telomere shortening in myocardium with heart weight gain and cause of death
Association of telomere shortening with impaired glucose tolerance and diabetic macroangiopathy
Asynchronous Shortening of telomere Length and Cardiovascular Outcomes
ATF7 mediates TNF-α–induced telomere shortening
Authors’ Response Correlation between baseline telomere length and shortening over time—spurious or true?
Biological age instead of chronologic age as prognostic factor in IPF: clinical implications of telomere shortening
Biomarkers of oxidative stress: methods and measures of oxidative DNA damage (COMET assay) and telomere shortening
BJ fibroblasts display high antioxidant capacity and slow telomere shortening independent of hTERT transfection
Blood cell telomere lengths and shortening rates of chimpanzee and human females
Bone morphogenetic protein-7 induces telomerase inhibition, telomere shortening, breast cancer cell senescence, and death via Smad3.
C21 MECHANISMS THAT LINK AGING WITH LUNG DISEASE: THE CUTTING EDGE: Acrolein Induces P53-Mediated Cellular Senescence Accompanied By Enhanced Werner’s Syndrome Protein Degradation And telomere shortening
Can leukocyte telomere shortening be a possible biomarker to track Huntington’s disease progression?
Can telomere shortening be the main indicator of non-viable fetus elimination?
Can telomere shortening explain sigmoidal growth curves?
Can telomere shortening in human peripheral blood leukocytes serve as a disease biomarker of Friedreich’s ataxia?
Candidate drug BIBR1532 induces telomere shortening and growth inhibition in lymphoid cell lines
Cardiomyocyte-Specific telomere shortening is a Distinct Signature of Heart Failure in Human
Cardiomyocyte‐Specific telomere shortening is a Distinct Signature of Heart Failure in Humans
Casein Kinase II (csnk2a2) is Associated With Leucocyte telomere shortening and Increased Cardiovascular Disease Risk in Diabetes
CD 57 identifies T cells with functional senescence before terminal differentiation and relative telomere shortening in patients with activated PI 3 kinase delta …
Celiac disease autoimmunity is associated with leukocyte telomere shortening in older adults: the US National Health and Nutrition Examination Survey
Cell contact accelerates replicative senescence of human mesenchymal stem cells independent of telomere shortening and p53 activation: roles of Ras and oxidative …
CELL CYCLE ARREST AND ACCELERATED telomere shortening IN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD)
Cell cycle-dependent and-independent telomere shortening accompanies murine brain aging
Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands
Cell senescence in rat kidneys in vivo increases with growth and age despite lack of telomere shortening
Cellular consequences of telomere shortening in histologically normal breast tissues
Cellular senescence mechanisms independent of telomere shortening and telomerase: other barriers to cell immortalization and carcinogenesis
CEREBRAL VASCULAR HEALTH AND ACCELERATED LEUKOCYTE telomere shortening IN TYPE II DIABETES.
Childhood maltreatment and telomere shortening: preliminary support for an effect of early stress on cellular aging
Chlorella vulgaris modulates hydrogen peroxide-induced DNA damage and telomere shortening of human fibroblasts derived from different aged individuals
Chromosomal instability and telomere shortening in long-term culture of hematopoietic stem cells: insights from a cell culture model of RPS14 haploinsufficiency
Chromosomal instability in Barrett’s esophagus is related to telomere shortening
Chromosomal instability in ulcerative colitis is related to telomere shortening
Chromosomal instability, telomere shortening, and inactivation of p21WAF1/CIP1 in dysplastic nodules of hepatitis B virus-associated multistep …
Chromosomal telomere shortening of kidney cells in IgA nephropathy by the measurement of DNA in urinary sediment.
Chronic Oxidative Stress Leads To Accelerated telomere shortening In Children With Alpha-1 Antitrypsin Deficiency
Chronic psychosocial and financial burden accelerates 5-year telomere shortening: findings from the Coronary Artery Risk Development in Young Adults Study
Clinical impact of telomere shortening in normal and leukemia cells in chronic lymphocytic leukemia
Clinical predictive factors and prognostic implications of telomere shortening in sporadic and familial idiopathic pulmonary fibrosis
Clonal haemopoiesis may occur after conventional chemotherapy and is associated with accelerated telomere shortening and defects in the NQO1 pathway; possible …
Cocaine use may induce telomere shortening in individuals with HIV infection
Colonocyte telomere shortening is greater with dietary red meat than white meat and is attenuated by resistant starch
Comments on “Is telomere shortening reversible? A clue from NASA’s twins mission”
Comparison of Southern blotting and Real-time PCR in measuring telomere shortening
Concomitant telomere shortening, acquisition of multiple chromosomal aberrations and in vitro resistance to apoptosis in a single case of progressive CLL
Consequences of acute oxidative stress in Leishmania amazonensis: From telomere shortening to the selection of the fittest parasites
Consequences of telomere shortening at an active VSG expression site in telomerase-deficient Trypanosoma brucei
Consequences of telomere shortening during lifespan
Constitutive OGG1 variant together with BRCA mutations display accelerated telomere shortening
Contact-independent suppressive activity of regulatory T cells is associated with telomerase inhibition, telomere shortening and target lymphocyte apoptosis
Contrasting effects of telomere shortening on organ homeostasis, tumor suppression, and survival during chronic liver damage
Convergence of adipocyte hypertrophy, telomere shortening and hypoadiponectinemia in obese subjects and in patients with type 2 diabetes
Conversion of normal to malignant phenotype: telomere shortening, telomerase activation, and genomic instability during immortalization of human oral keratinocytes
Correlates of telomere length shortening in peripheral leukocytes of HIV-infected individuals and association with leukoaraiosis
Correlation of telomere length shortening with promoter methylation profile of p16/Rb and p53/p21 pathways in breast cancer
Correlation of telomere length shortening with TP53 somatic mutations, polymorphisms and allelic loss in breast tumors and esophageal cancer
Correlation telomere shortening in chronic lymphocytic leukemia cells with oxidative stress and dysregulation of shelterin proteins
Correlative polymorphism of NAD (P) H: quinone oxidoreductase (NQO1) with telomere shortening in colorectal cancer.
Cortisol increases DNA damage in lymphocytes in vitro, but is not associated with telomere shortening
Cortisol is not associated with telomere shortening or chromosomal instability in human lymphocytes cultured under low and high folate conditions
Critical telomere shortening regulated by the ataxia-telangiectasia gene acts as a DNA damage signal leading to activation of p53 protein and limited life-span …
CTC1 increases the radioresistance of human melanoma cells by inhibiting telomere shortening and apoptosis
Curcumin inhibits telomerase and induces telomere shortening and apoptosis in brain tumour cells
Data Mining in the Research and Application of telomere shortening
Decreased dyskerin levels as a mechanism of telomere shortening in X-linked dyskeratosis congenita
Decreasing initial telomere length in humans intergenerationally understates age‐associated telomere shortening
Deficiency in DNA mismatch repair increases the rate of telomere shortening in normal human cells
Demonstration of potential link between helicobacter pylori related promoter CpG island methylation and telomere shortening in human gastric mucosa
Deoxyribonucleic acid telomere length shortening can predict the incidence of non‐alcoholic fatty liver disease in patients with type 2 diabetes mellitus
Deregulated telomere transcription causes replication-dependent telomere shortening and promotes cellular senescence
Developing a Model for Stress-Associated telomere shortening: Effects of Stress-Related Mediators on Telomerase Activity
Development of a new multiplex quantitative real‐time PCR assay for the detection of the mtDNA4977 deletion in coronary artery disease patients: A link with telomere shortening
Diet Influences telomere shortening: Eating Your Way to the Fountain of Youth?
Diet-Induced Leukocyte telomere shortening Correlates with Extent of Atherosclerosis
Diet-induced leukocyte telomere shortening in a baboon model for early stage atherosclerosis
Diet-related telomere shortening and chromosome stability
Different effects of accelerated development and enhanced growth on oxidative stress and telomere shortening in amphibian larvae
Different Phase of telomere shortening with Age in Peripheral Blood Mononuclear Cells
Different rates of telomere shortening and telomerase activity reduction in CD8 T and CD16 NK lymphocytes with ageing
Differential expression of non-shelterin genes associated with high telomerase levels and telomere shortening in plasma cell disorders
Differential shortening rate of telomere length in the development of human fetus
Differential telomere shortening in blood versus arteries in an animal model of type 2 diabetes
Differential timing of oxidative DNA damage and telomere shortening in hepatitis C and B virus–related liver carcinogenesis
Disease anticipation is associated with progressive telomere shortening in families with dyskeratosis congenita due to mutations in TERC
Divergent patterns of telomere shortening in tropical compared to temperate stonechats
DNA damage and telomere length shortening in the peripheral blood leukocytes of 20 years SM-exposed veterans
DNA Damage and telomere shortening in Embryonic Stem Cells Induced by Cigarette Smoke.
DNA damage response correlates with telomere shortening and telomeric proteins down regulation in the colorectal multistep process
DNA demethylation leads to telomere shortening with accelerated aging process in human diploid fibroblasts
DNA methylation of human telomerase reverse transcriptase associated with leukocyte telomere length shortening in hyperhomocysteinemia-type hypertension in …
Does telomere shortening precede the onset of hypertension in spontaneously hypertensive mice?
Downregulation of methyltransferase Dnmt2 results in condition‐dependent telomere shortening and senescence or apoptosis in mouse fibroblasts
Down-regulation of telomerase activity and replication-independent telomere shortening induced by SH-7 in human leukemia HL-60 cells
Dynamics of telomere shortening in neutrophils and T lymphocytes during ageing and the relationship to skewed X chromosome inactivation patterns
Dyslipidemia and chronic inflammation markers are correlated with telomere length shortening in Cushing’s syndrome
Dysregulation of shelterin factors coupled with telomere shortening in Philadelphia chromosome negative myeloproliferative neoplasms
Early and late steps in telomere overhang processing in normal human cells: the position of the final RNA primer drives telomere shortening
Early growth determines longevity in male rats and may be related to telomere shortening in the kidney
Early Senescence and Leukocyte telomere shortening in SCHIZOPHRENIA: A Role for Cytomegalovirus Infection?
Early telomere shortening and Genomic Instability in Tubo-Ovarian Preneoplastic Lesions
Early telomere shortening and genomic instability in tubo-ovarian preneoplastic lesions—response
Early-senescing human skin fibroblasts do not demonstrate accelerated telomere shortening
Effect of D-gal on mouse fibroblast telomere shortening
Effect of maternal protein restriction upon growth, longevity and telomere shortening
Enhanced microglial pro‐inflammatory response to lipopolysaccharide correlates with brain infiltration and blood–brain barrier dysregulation in a mouse model of telomere shortening
Enhanced telomere shortening in transformed lymphoblasts from patients with X linked dyskeratosis
Epigallocatechin‐3‐gallate induces telomere shortening and clastogenic damage in glioblastoma cells
Estimating age of humans based on telomere shortening
Estimation of human age according to telomere shortening in peripheral blood leukocytes
Estimation of human age according to telomere shortening in peripheral blood leukocytes of Tibetan
Estrogen deficiency leads to telomerase inhibition, telomere shortening and reduced cell proliferation in the adrenal gland of mice
Estrogen deficiency reversibly induces telomere shortening in mouse granulosa cells and ovarian aging in vivo
EVALUATION OF DYNAMIC telomere LENGTH SHORTENING OF LYMPHOCYTES IN IMMUNOCOMPROMISED CHILDREN WITH CHRONIC DISEASES OF THE …
Evaluation of the mechanism of nucleoplasmic bridge formation due to premature telomere shortening in agricultural workers exposed to mixed pesticides …
Examining a scaled dynamical system of telomere shortening
Excess Neurohormonal Activation-Induced Heart Failure Results in Significant but Non-Critical Cardiomyocyte telomere shortening, Which is Associated With …
Excess of Yra1 RNA-Binding Factor Causes Transcription-Dependent Genome Instability, Replication Impairment and telomere shortening
Exercise training increase antioxidant enzyme capacity and protect the shortening of telomere length
Exome Sequencing Links Loss-of-Function and Missense Mutations in PARN and RTEL1 with Familial Pulmonary Fibrosis and telomere shortening
Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening
Expression of miR-23a induces telomere shortening and is associated with poor clinical outcomes in patients with coronary artery disease
Expression of mutant RPA in human cancer cells causes telomere shortening
Expression of TRF1, TRF2, TIN2, TERT, KU70, and BRCA1 proteins is associated with telomere shortening and may contribute to multistage carcinogenesis of gastric …
Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening
F19. telomere shortening IN YOUNG PEOPLE WITH FIRST EPISODE PSYCHOSIS: A 12-MONTH FOLLOW-UP STUDY
Fetal growth restriction is associated with accelerated telomere shortening and increased expression of cell senescence markers in the placenta
Flow cytometric detection of accelerated telomere shortening in myelodysplastic syndromes: correlations with aetiological and clinical–biological findings
Forensic application of telomere shortening in age-at-death estimation
Fragmentation and rapid shortening of telomere in HeLa cells in the early phase of hydroxyl radical-induced apoptosis
From cellular senescence to Alzheimer’s disease: The role of telomere shortening
From incomplete penetrance with normal telomere length to severe disease and telomere shortening in a family with monoallelic and biallelic PARN pathogenic …
Functional haplotypes of the hTERT gene, leukocyte telomere length shortening, and the risk of peripheral arterial disease
Fusing Aging Theories: telomere shortening Leads to Mitochondrial Dysfunction Fusing Aging Theories: telomere shortening Leads to Mitochondrial …
Gemcitabine causes telomere shortening by stabilizing TRF2
Gender specific profiles of human telomere shortening during aging
Gene disruption of a G4-DNA-dependent nuclease in yeast leads to cellular senescence and telomere shortening
Genetic anticipation is associated with telomere shortening in hereditary breast cancer
Genetic heterogeneity of HER2 amplification and telomere shortening in papillary thyroid carcinoma
Genomic imbalances in key ion channel genes and telomere shortening in sudden cardiac death victims
Genotoxic risk of ethyl‐paraben could be related to telomere shortening
Ginger (Zingiber officinale) Extract Promotes telomere shortening and Induces Cellular Senescence in A549 Lung Cancer Cells
Ginger Extract Promotes telomere shortening and Cellular Senescence in A549 Lung Cancer Cells
GP 12.03 telomere shortening and telomere-associated proteins in Duchenne muscular dystrophy
Gradual telomere shortening and increasing chromosomal instability among PanIN grades and normal ductal epithelia with and without cancer in the …
Growth arrest, apoptosis, and telomere shortening of Barrett’s-associated adenocarcinoma cells by a telomerase inhibitor
Growth kinetics rather than stress accelerate telomere shortening in cultures of human diploid fibroblasts in oxidative stress‐induced premature senescence
Growth kinetics rather than stress accelerate telomere shortening in cultures of human diploid fibroblasts in oxidative…
Haploinsufficiency of Parp1 accelerates Brca1-associated centrosome amplification, telomere shortening, genetic instability, apoptosis, and embryonic …
Helicobacter pylori-induced chronic inflammation causes telomere shortening of gastric mucosa by promoting PARP-1-mediated non-homologous end joining of DNA
Hepatocellular telomere shortening correlates with chromosomal instability and the development of human hepatoma
Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis
Hepatocyte telomere shortening of primary HCC correlates with increasing aneuploidy of chromosome 8
High lead exposure is associated with telomere length shortening in Chinese battery manufacturing plant workers
High resolution telomere FISH analysis of testicular germ cell tumors reveals telomere anomalies specific to cancer subtypes and demonstrates telomere shortening as an early event in TGCT carcinogenesis
Higher serum phenylalanine concentration is associated with more rapid telomere shortening in men
Hostility and telomere shortening among US military veterans: Results from the National Health and Resilience in Veterans Study
Hydroxyl radical‐induced apoptosis in human tumor cells is associated with telomere shortening but not telomerase inhibition and caspase activation
Immortalization of human oral keratinocytes is associated with elevation of telomerase activity and shortening of telomere length.
Immunosenescence and rheumatoid arthritis: does telomere shortening predict impending disease?
Impact of telomere shortening on cell cycle progression and induction of senescence
Impact of telomere shortening with Age in Stem Cell Therapy: New Strategies to Increase telomere Length
Improved Methods for Analysis of Telomere-initiated Cellular Senescence and telomere shortening in Saccharomyces Cerevisiae
In vitro proinflammatory gene expression predicts in vivo telomere shortening: A preliminary study
In utero TNF‐α treatment induces telomere shortening in young adult mice in an ATF7‐dependent manner
Increased expression of p21 in CD14+ human monocytes correlates with telomere shortening in ocular sarcoidosis patients
Increased genomic alteration complexity and telomere shortening in B-CLL cells resistant to radiation-induced apoptosis
Independent and Combined Effects of telomere shortening and mtDNA4977 Deletion on Long-term Outcomes of Patients with Coronary Artery Disease
Induction of nitric oxide synthase-dependent telomere shortening after functional inhibition of Hsp90 in human tumor cells
Induction of telomere shortening and cellular apoptosis by sodium meta-arsenite in human cancer cell lines
Induction of telomere shortening and replicative senescence by cryopreservation
Inflammatory response to acute mental stress is associated with altered cortisol reactivity and telomere shortening in patients with coronary artery disease
Inhibition of 6A8 α-mannosidase gene expression resulted in telomere length shortening in nasopharyngeal carcinoma cell CNE-2L2
Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death
Inhibition of microRNA-34a Protects against Aging and Progeria Associated Cardiac Dysfunction by Interfering with telomere shortening and DNA Damage …
Inhibition of tankyrase 1 in human gastric cancer cells enhances telomere shortening by telomerase inhibitors
INSULIN RESISTANCE DETERMINES telomere shortening IN PHAGOCYTIC CELLS FROM METABOLIC SYNDROME PATIENTS. INVOLVEMENT OF …
Intramitotic and intraclonal variation in proliferative potential of human diploid cells: explained by telomere shortening
Inula Viscosa Extracts Induces telomere shortening and Apoptosis in Cancer Cells and Overcome Drug Resistance
Investigation of telomere shortening caused by dyskeratosis congenita-associated heterozygous TIN2 mutations
Ionizing radiation-induced gene modulations, cytokine content changes and telomere shortening in mouse fetuses exhibiting forelimb defects
iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors
Irreversible cellular senescence induced by prolonged exposure to H2O2 involves DNA-damage-and-repair genes and telomere shortening
Irreversible telomere shortening by 3′-azido-2′, 3′-dideoxythymidine (AZT) treatment
Is telomere Length shortening a Predictive Biomarker for Cancer Risk in Ulcerative Colitis?
Is telomere shortening Related to Progeria?
Is telomere shortening reversible? A clue from NASA’s Twin study.
Knockdown of homeobox containing 1 increases the radiosensitivity of cervical cancer cells through telomere shortening
Lack of age‐associated telomere shortening in long‐and short‐lived species of sea urchins
Lack of telomerase causes telomere shortening in RA
Lack of telomere shortening during senescence in Paramecium.
Lack of telomere shortening with age in mouse resting zone chondrocytes
Lactobacilli modulated AMPK activity and prevented telomere shortening in ageing rats
L-carnosine reduces telomere damage and shortening rate in cultured normal fibroblasts
Leucocyte telomere shortening in relation to newly diagnosed type 2 diabetic patients with depression
Leucocyte telomere shortening is associated with nonalcoholic fatty liver disease‐related advanced fibrosis
Leukocyte telomere Length Shortening and Alzheimer’s Disease Etiology
Leukocyte telomere Length Shortening, hTERT Genetic Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia
Leukocyte telomere shortening in elderly Type2DM patients with previous myocardial infarction
Leukocyte telomere shortening in grown-up patients with congenital heart disease
Leukocyte telomere shortening in Huntington’s disease
Leukocyte telomere shortening in staff working in cardiac catheterization laboratory
Lifetime pesticide use and telomere shortening among male pesticide applicators in the Agricultural Health Study
Limited telomere shortening in hematopoietic stem cells after transplantation
Lineage-specific telomere shortening and unaltered capacity for telomerase expression in human T and B lymphocytes with age
Lipid peroxidation-mediated telomere shortening in hydroxyl radical-induced apoptosis in HeLa cells
Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening
Longitudinal associations between metabolic syndrome components and telomere shortening
Longitudinal telomere length shortening and cognitive and physical decline in later life: The Lothian Birth Cohorts 1936 and 1921
Longitudinal telomere shortening and early Alzheimer’s disease progression in adults with down syndrome
Longitudinal versus cross-sectional evaluations of leukocyte telomere length dynamics: age-dependent telomere shortening is the rule
Long‐term follow‐up of recipients of allogeneic bone marrow grafts reveals no progressive telomere shortening and provides no evidence for haematopoietic stem …
Long-term lymphoma survivors following high-dose chemotherapy and autograft: evidence of permanent telomere shortening in myeloid cells, associated with marked …
Lower antioxidant capacity and elevated p53 and p21 may be a link between gender disparity in renal telomere shortening, albuminuria, and longevity
LSC Abstract–Increased oxidative stress leads to telomere shortening in children with alpha-1 antitrypsin deficiency
Luminal and cancer cells in the breast show more rapid telomere shortening than myoepithelial cells and fibroblasts
Lung alveolar integrity is compromised by telomere shortening in telomerase-null mice
Lung function and telomere shortening in blood leukocytes in clean-up workers of Chornobyl NPP suffered of COPD
Mammalian telomere dynamics: healing, fragmentation shortening and stabilization
Marked telomere shortening in mobilized peripheral blood progenitor cells (PBPC) following two tightly spaced high-dose chemotherapy courses with G-CSF
Markers of cellular senescence. telomere shortening as a marker of cellular senescence
Maternal smoking hastens telomere shortening in neonatal umbilical cord blood leukocytes
Maternal‐fetal cross talk through cell‐free fetal DNA, telomere shortening, microchimerism, and inflammation
Mathematical modeling confirms the length-dependency of telomere shortening
Mathematical modeling of telomere shortening: an overview
Mathematical modeling of vascular endothelial layer maintenance: the role of endothelial cell division, progenitor cell homing, and telomere shortening
Mathematical Models and Computer Simulations of telomere shortening
Mean leukocyte telomere length shortening and type 2 diabetes mellitus: a case-control study
Measurement of telomere length in cells from pleural effusion: Asbestos exposure causes telomere shortening in pleural mesothelial cells
Mechanism of acridine-based telomerase inhibition and telomere shortening
Mechanism of p53 Accumulation and Activation by Ionizing Radiation and telomere shortening
Mechanism of telomere shortening by oxidative stress
Mechanism of telomere shortening in photoaging model induced by 8-methoxypsoralen and ultraviolet A
Mechanisms of breast cancer risk in shift workers: association of telomere shortening with the duration and intensity of night work
Mechanisms of telomere shortening in placentas from pregnancies complicated with intrauterine growth restriction
Medaka fish exhibits longevity gender gap, a natural drop in estrogen and telomere shortening during aging: a unique model for studying sex-dependent …
Microbiota and telomere shortening in gut-lung axis of human immunodeficiency virus infected donors
Minimal Shortening of Leukocyte telomere Length Across Age Groups in a Cross-Sectional Study for Carriers of a Longevity-Associated FOXO3 Allele
Mitogen stimulation cooperates with telomere shortening to activate DNA damage responses and senescence signaling
MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress
Modeling of the Process of telomere shortening: an Overview
Modelling telomere shortening and the role of oxidative stress
Moderate stem-cell telomere shortening rate postpones cancer onset in a stochastic model
Monocyte telomere shortening and oxidative DNA damage in type 2 diabetes
Mutated telomeres sensitize tumor cells to anticancer drugs independently of telomere shortening and mechanisms of telomere maintenance
Mutations in XLF/NHEJ1/Cernunnos gene results in downregulation of telomerase genes expression and telomere shortening
Nanoparticle mediated delivery of 2′-O-methyl-RNA leads to efficient telomerase inhibition and telomere shortening in human lung cancer cells
Nestling telomere shortening, but not telomere length, reflects developmental stress and predicts survival in wild birds
Neural Correlates and Peripheral miRNAs Associated with Stress-Related telomere shortening
No evidence of substantia nigra telomere shortening in Parkinson’s disease
No telomere shortening in marrow stroma from patients with MDS
Nonmyeloablative conditioning does not prevent telomere shortening after allogeneic stem cell transplantation
Novel and potent telomerase antagonist (GRN163L) inhibits telomerase activity, resulting in telomere shortening and apoptosis of multiple myeloma cells
Novel biomolecules of ageing, sex differences and potential underlying mechanisms of telomere shortening in coronary artery disease
Nutrition, oxidative damage, telomere shortening, and cellular senescence: individual or connected agents of aging?
On telomere shortening in soft-tissue tumors
On the origin of Robertsonian fusions in nature: evidence of telomere shortening in wild house mice
OP20 Hepatocytes and cholangiocytes do not have significant telomere shortening with increasing chronological age in normal livers
Organization of telomere sequences in birds: evidence for arrays of extreme length and for in vivo shortening
Osteoarthritis and telomere shortening
Oxidative DNA damage and telomere shortening
Oxidative stress and telomere shortening in normal human fibroblasts after ir-radiation with X-rays
Oxidative stress, telomere shortening, and DNA methylation in relation to low‐to‐moderate occupational exposure to welding fumes
Oxidative stress‐induced renal telomere shortening as a mechanism of cyclosporine‐induced nephrotoxicity
Oxidative stress-induced telomere length shortening of circulating leukocyte in patients with obstructive sleep apnea
P-039: telomere shortening and/or “absence” may indicate dementia/AD status in older individuals with down syndrome
P3995Advanced glycation end-products and telomere shortening contribute to cardiac aging: the relationship with myocardial strain
P838Expression of miR-23a induces leukocyte telomere shortening and is associated with poor clinical outcomes in patients with coronary artery disease
Parallel telomere shortening in multiple body tissues owing to malaria infection
Patients with multiple sclerosis show increased oxidative stress markers and somatic telomere length shortening
Pharmacodynamics of telomerase inhibition and telomere shortening by noncytotoxic suramin
Phosphorylation of telomeric repeat binding factor 1 (TRF1) by Akt causes telomere shortening
Placental Ageing in Adverse Pregnancy Outcomes: telomere shortening, Cell Senescence, and Mitochondrial Dysfunction
Placental telomere shortening in stillbirth: a sign of premature senescence?
Platinum (II) phenanthroimidazole G-quadruplex ligand induces selective telomere shortening in A549 cancer cells
Poor maternal nutrition followed by accelerated postnatal growth leads to telomere shortening and increased markers of cell senescence in rat islets
Potential CO2 effects on telomere shortening in Porites lutea & Method improvements for telomere assessment in corals
Predictive factors and prognostic effect of telomere shortening in pulmonary fibrosis
Premature telomere shortening and impaired regenerative response in hepatocytes of individuals with NAFLD
Premature telomere shortening in polymorphonuclear neutrophils from patients with systemic lupus erythematosus is related to the lupus disease activity
Prevalence of telomere shortening in familial and sporadic pulmonary fibrosis is increased in men
Prevention of critical telomere shortening by oestradiol in human normal hepatic cultured cells and carbon tetrachloride induced rat liver fibrosis
Prevention of Radiation-Induced telomere shortening, A Novel Mechanism Underlying Low-Dose Arsenic-Mediated Protection of Normal T-Lymphocytes
Prevention Of telomere shortening
Pro12Ala Polymorphism of the PPARγ2 Gene Interacts With a Mediterranean Diet to Prevent telomere shortening in the PREDIMED-NAVARRA Randomized Trial
Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesis
Progressive telomere shortening is part of the natural history of chronic lymphocytic leukaemia and impacts clinical outcome: evidences from long term follow-up.
Progressive telomere shortening occurs in cultured rat microglia, but not astrocytes
Progressive telomere shortening of Epstein-Barr virus-specific memory T cells during HIV infection: contributor to exhaustion?
Prostate stromal cell telomere shortening is associated with risk of prostate cancer in the placebo arm of the Prostate Cancer Prevention Trial
Proteomic and microRNA data clarifying the effects of telomere shortening on cancer cells
Proximity to roads, but not exposure to metal pollution, is associated with accelerated developmental telomere shortening in nestling great tits
Race-related health disparities and biological aging: does rate of telomere shortening differ across blacks and whites?
Radiation and chemotherapy bystander effects induce early genomic instability events: telomere shortening and bridge formation coupled with mitochondrial …
Radiation-induced senescence-like growth arrest requires TP53 function but not telomere shortening
Radiobiological effectiveness of ultrashort laser-driven Electron bunches: micronucleus frequency, telomere shortening and cell viability
Rapid telomere shortening in children
Rate of telomere shortening and cardiovascular damage: a longitudinal study in the 1946 British Birth Cohort
RATE OF telomere shortening AND CARDIOVASCULAR PHENOTYPES
Rate of telomere shortening and metabolic and cardiovascular risk factors: A longitudinal study in the 1934–44 Helsinki Birth Cohort Study
Recent advances of Blood telomere length (BTL) shortening: A potential biomarker for development of cancer
Relationship between microsatellite instability and telomere shortening in colorectal cancer
Relationship between spontaneous or radiation-induced apoptosis and telomere shortening in G0 human lymphocytes
Relationship between telomere shortening, genetic instability, and site of tumour origin in colorectal cancers
Renal failure induces telomere shortening in the rat heart
Replicative senescence as a model of aging: the role of oxidative stress and telomere shortening–an overview
Replicative senescence of hematopoietic stem cells during serial transplantation: does telomere shortening play a role?
Replicative senescence, telomere shortening and cell proliferation rate in Gaddi goat’s skin fibroblast cell line
Resistance to senescence induction and telomere shortening by a G-quadruplex ligand inhibitor of telomerase
Response to comments on is telomere shortening reversible? A clue from NASA’s twins mission
Reversibility of defective hematopoiesis caused by telomere shortening in telomerase knockout mice
Revisiting telomere shortening in Cancer
Ribozyme-mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells
Robertsonian translocation as a result of telomere shortening during replicative senescence and immortalization of bovine oviduct epithelial cells
Role of arterial telomere dysfunction in hypertension: relative contributions of telomere shortening and telomere uncapping
Role of cell‐cycle turnover and oxidative stress in telomere shortening and cellular senescence in patients with chronic hepatitis C
Role of Oxidative DNA Damage in telomere shortening and Cellular Aging
Role of oxidative stress in telomere shortening in cultured fibroblasts from normal individuals and patients with ataxia–telangiectasia
Role of shelterin proteins for telomere shortening in chronic lymphocytic leukemia
Saccharomyces cerevisiae as a model to study replicative senescence triggered by telomere shortening
Senescence and chromosomal instability induced by telomere shortening affect liver regeneration and hepatocarcinogenesis
Senescence and telomere shortening induced by novel potent G-quadruplex interactive agents, quindoline derivatives, in human cancer cell lines
Senescence occurs with hTERT repression and limited telomere shortening in human oral keratinocytes cultured with feeder cells
Senescence, telomere shortening and telomere maintenance
Sepsis induces telomere shortening: a potential mechanism responsible for delayed pathophysiological events in sepsis survivors?
Sex-dependent telomere shortening, telomerase activity and oxidative damage in marine medaka Oryzias melastigma during aging
Shortening of telomere length by metabolic factors in diabetes: protective effects of fenofibrate
Shortening telomere is associated with subclinical atherosclerosis biomarker in omnivorous but not in vegetarian healthy men
Significant telomere shortening in acute and chronic leukemia
Significant telomere shortening in childhood leukemia
Site‐specific DNA damage at GGG sequence by oxidative stress may accelerate telomere shortening
Site-specific DNA damage at the GGG sequence by UVA involves acceleration of telomere shortening
Six-year telomere shortening is associated with increased incidence of subclinical carotid vascular damage and cardiovascular prognosis
Slow‐down of age‐dependent telomere shortening is executed in human skin keratinocytes by hormesis‐like‐effects of trace hydrogen peroxide or by anti‐oxidative …
SORBS2 transcription is activated by telomere position effect–over long distance upon telomere shortening in muscle cells from patients with facioscapulohumeral …
Stochastic mechanism of cellular aging—abrupt telomere shortening as a model for stochastic nature of cellular aging
Stochastic modeling of length-dependent telomere shortening in Corvus monedula
Stochastic Modeling of telomere Biology: Probabilistic Analysis of telomere shortening and Network-Based Approach to Gene Expression Analysis
Stochastic modelling in molecular biology: a probabilistic analysis of protein polymerisation and telomere shortening
Stochastic modelling of length dependent telomere shortening in
Stochastic models of telomere shortening
Stochastic telomere shortening and the Route to Limitless Replicative Potential
Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span
Stress and telomere shortening among central Indian conservation refugees
Stress induced telomere shortening: longer life with less mutations?
Stress resilience: Narrative identity may buffer the longitudinal effects of chronic caregiving stress on mental health and telomere shortening
Subclinical inflammation, telomere shortening, homocysteine, vitamin B6, and mortality: the Ludwigshafen Risk and Cardiovascular Health Study
Substantial telomere shortening in the substantia nigra of telomerase-deficient mice does not increase susceptibility to MPTP-induced dopamine depletion
Supplemental Data telomere shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a
Suppression of Ku80 correlates with radiosensitivity and telomere shortening in the U2OS telomerase-negative osteosarcoma cell line
Syndromes Associated with telomere shortening
Syndromes of telomere shortening
T cell renewal rates, telomerase, and telomere length shortening
Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation.
Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress
Telomerase gene mutations and telomere length shortening in patients with idiopathic pulmonary fibrosis in a C hinese population
Telomerase inhibition by 3′-azido-2′, 3′-dideoxynucleoside 5′-triphosphates and telomere shortening in human cultured cells by the corresponding nucleosides
Telomerase Inhibition, telomere shortening, and Cellular Uptake of the Perylene Derivatives PM2 and PIPER in Prostate Cancer Cells
Telomerase Inhibition, telomere shortening, and Decreased Cell Proliferation by Cell Permeable 2′-O-Methoxyethyl Oligonucleotides
Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins
Telomerase inhibition, telomere shortening, cell growth suppression and induction of apoptosis by telomestatin in childhood neuroblastoma cells
Telomerase regulation and progressive telomere shortening of rat hepatic stem-like epithelial cells during in vitro aging
telomere and its role in the aging pathways: telomere shortening, cell senescence and mitochondria dysfunction
telomere G-quadruplex as a potential target to accelerate telomere shortening by expanding the incomplete end-replication of telomere DNA
telomere Length Inheritance and Shortening in Trisomy 21
telomere length maintenance, shortening, and lengthening
telomere length shortening and gastric cancer risk in a high risk Polish population
telomere length shortening in Alzheimer’s disease: procedures for a causal investigation using single nucleotide polymorphisms in a mendelian randomization study
telomere length shortening in gastric mucosa is a field effect associated with increased risk of gastric cancer
telomere length shortening in Langerhans cell histiocytosis
telomere Length Shortening in Malignant Patients Undergoing Chemotherapy
telomere length shortening in non-Hodgkin’s lymphoma patients undergoing chemotherapy
telomere length shortening in patients with dementia with Lewy bodies
telomere length shortening is associated with disease evolution in chronic myelogenous leukemia
telomere length shortening is associated with treatment-free remission in chronic myeloid leukemia patients
telomere length shortening of peripheral blood mononuclear cells in solid-cancer patients undergoing standard-dose chemotherapy might be correlated with good …
telomere longitudinal shortening as a biomarker for dementia status of adults with Down syndrome
telomere position effect: regulation of gene expression with progressive telomere shortening over long distances
telomere shortening & metabolic/vascular diseases
telomere shortening Abrogates Dentate Gyrus Neurogenesis But Improves Alzheimer’S Disease Progression In Mice
telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells
telomere shortening activates TGF-β/Smads signaling in lungs and enhances both lipopolysaccharide and bleomycin-induced pulmonary fibrosis
telomere shortening alters the kinetics of the DNA damage response after ionizing radiation in human cells
telomere shortening among male applicators in the Agricultural Health Study
telomere shortening and accelerated aging in COPD: findings from the BODE cohort
telomere shortening and age estimation in forensic medicine
telomere shortening and ageing
telomere shortening and ageing of the immune system
telomere shortening and Alzheimer’s disease
telomere shortening and aortic plaque progression in Apoliprotein E knockout mice after pulmonary exposure to candle light combustion particles
telomere shortening and apoptosis in telomerase-inhibited human tumor cells
telomere shortening and associated chromosomal instability in peripheral blood lymphocytes of patients with Hodgkin’s lymphoma prior to any treatment are …
telomere shortening and atherosclerosis
telomere shortening and cell cycle arrest in Trypanosoma brucei expressing human telomeric repeat factor TRF1
telomere shortening and cell cycle arrest induced by p16 gene introduction in human breast cancer MCF-7 cells
telomere shortening and cell fates in mouse models of neoplasia
telomere shortening and cell senescence induced by perylene derivatives in A549 human lung cancer cells
telomere shortening and cellular senescence in a model of chronic renal allograft rejection
telomere shortening and chromosomal abnormalities in intestinal metaplasia of the urinary bladder
telomere shortening and chromosomal instability abrogates proliferation of adult but not embryonic neural stem cells
telomere shortening and chromosomal instability in myelodysplastic syndromes
telomere shortening and decline in replicative potential as a function of donor age in human adrenocortical cells
telomere shortening and decreased replicative potential, contrasted by continued proliferation of telomerase-positive CD8+ CD28lo T cells in patients with systemic …
telomere shortening and DNA damage of embryonic stem cells induced by cigarette smoke
telomere shortening and frailty in Mexican older adults
telomere shortening and Growth Inhibition of Human Cancer Cells by Novel Synthetic Telomerase Inhibitors MST-312, MST-295, and MST-199 1 Supported in part …
telomere shortening and haemodialysis
telomere shortening and immune activity in war veterans with posttraumatic stress disorder
telomere shortening and inactivation of cell cycle checkpoints characterize human hepatocarcinogenesis
telomere shortening and increased oxidative stress are restricted to venous tissue in patients with varicose veins: A merely local disease?
telomere shortening and ionizing radiation: a possible role in vascular dysfunction?
telomere shortening and karyotypic alterations in hepatocytes in long‐term transplanted human liver allografts
telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells
telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy
telomere shortening and mitotic dysfunction generate cytogenetic heterogeneity in a subgroup of renal cell carcinomas
telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated aging
telomere shortening and oxidative stress in aged macrophages results in impaired STAT5a phosphorylation
telomere shortening and oxidative stress in patients with COPD
telomere shortening and p21-checkpoint inactivation characterize multistep hepatocarcinogenesis in humans
telomere shortening And Progression In Patients With Chronic Obstructive Pulmonary Disease (COPD)
telomere shortening and regenerative capacity after acute kidney injury
telomere shortening and stem cell failure in dyskeratosis congenita
telomere shortening and survival in free-living corvids
telomere shortening and Telomerase Activation during Cancer Formation
telomere shortening and telomerase activity in ischaemic cardiomyopathy patients–potential markers of ventricular arrhythmia
telomere shortening and telomerase expression during multistage carcinogenesis of intraductal papillary mucinous neoplasms of the pancreas
telomere shortening and telomerase reactivation in dysplastic nodules of human hepatocarcinogenesis
telomere shortening and telomerase reverse transcriptase expression in preinvasive bronchial lesions
telomere shortening and telomere position effect in mild ring 17 syndrome
telomere shortening and the clinicopathologic characteristics of human colorectal carcinomas
telomere shortening and the population size-dependency of life span of human cell culture: further implication for two proliferation-restricting telomeres
telomere shortening and tumor formation by mouse cells lacking telomerase RNA
telomere shortening as a genetic risk factor for the development of cirrhosis
telomere shortening as a hallmark of stem cell senescence
telomere shortening as a mechanism of long-term cost of infectious diseases in natural animal populations
telomere shortening as genetic risk factor of liver cirrhosis
telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.
telomere shortening associated with disease evolution patterns in myelodysplastic syndromes
telomere shortening associated with increased genomic complexity in chronic lymphocytic leukemia
telomere shortening associated with increased levels of oxidative stress in sulfur mustard-exposed Iranian veterans
telomere shortening Behind the Harm of Immunosuppressive Therapy In Idiopathic Pulmonary Fibrosis
telomere shortening by cisplatin in yeast nucleotide excision repair mutant
telomere shortening by mutations in the RTEL1 helicase cause severe form of dyskeratosis congenita, Hoyerall-Hreidarsson syndrome.
telomere shortening By Terc Knockout in the Eµ-TCL1 Transgenic Murine Model of CLL: Characterization of Disease Development and Survival
telomere shortening by transgenerational transmission of TNF-α-induced TERRA via ATF7
telomere shortening correlates to dysplasia but not to DNA aneuploidy in longstanding ulcerative colitis
telomere shortening correlates with increasing aneuploidy of chromosome 8 in human hepatocellular carcinoma
telomere shortening correlates with leukemic stem cell burden at diagnosis of chronic myeloid leukemia
telomere shortening correlates with prognostic score at diagnosis and proceeds rapidly during progression of chronic myeloid leukemia
telomere shortening distinguishes inverted urothelial neoplasms
telomere shortening does not occur during postmaturational aging in situ in normal human oral fibroblasts
telomere shortening during aging of human osteoblasts in vitro and leukocytes in vivo: lack of excessive telomere loss in osteoporotic patients
telomere shortening during aging: attenuation by antioxidants and anti-inflammatory agents
telomere shortening Exposes Functions
telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes
telomere shortening impairs organ regeneration by inhibiting cell cycle re‐entry of a subpopulation of cells
telomere shortening impairs regeneration of the olfactory epithelium in response to injury but not under homeostatic conditions
telomere shortening in a long-lived marine bird: cross-sectional analysis and test of an aging tool
telomere shortening in a Telomerase Null Mouse Model Restores Susceptibility to Bleomycin-Induced Lung Fibrosis.
telomere shortening in Aging, Coronary Heart Disease and Cerebrovascular Diseases [J]
telomere shortening in alcohol dependence: Roles of alcohol and acetaldehyde
telomere shortening in alveolar macrophages of smokers and COPD patients
telomere shortening in Alzheimer’s disease patients
telomere shortening in atherosclerosis
telomere shortening in Barrett’s mucosa and esophageal adenocarcinoma and its association with loss of heterozygosity
telomere shortening in blood leukocytes of patients with chronic obstructive pulmonary disease
telomere shortening in blood leukocytes of patients with posttraumatic stress disorder
telomere shortening in breast cancer cells (MCF7) under treatment with low doses of the benzylisoquinoline alkaloid chelidonine
telomere shortening in breast cancer correlates with the pathological features of tumor progression
telomere shortening in cancer cells by electrolyzed-reduced water
telomere shortening in centroacinar-acinar region of the pancreas: relationships with aging, cancers and tissue stem cells
telomere shortening in chronic liver diseases
telomere shortening in chronic obstructive pulmonary disease
telomere shortening in CLL Correlates with Cell Cycle-Dependent Dysregulation of Shelterin Proteins
telomere shortening In COPD And Lung Cancer: A Pilot Study In Chronic Smokers
telomere shortening in cultured autografts of patients with burns
telomere shortening in cultured human dermal fibroblasts is associated with acute photodamage induced by UVA irradiation
telomere shortening in diabetic rats: effects of dietary intervention with fisetin and n-acetylcysteine
telomere shortening in diaphragm and tibialis anterior muscles of aged mdx mice
telomere shortening in Down Syndrome Patients—When Does It Start?
telomere shortening in elderly individuals with mild cognitive impairment may be attenuated with ω-3 fatty acid supplementation: a randomized controlled pilot study
telomere shortening in elderly individuals with mild cognitive impairment may be attenuated with¿-3 fatty acid supplementation: a randomized controlled pilot study
telomere shortening in elderly people with mild cognitive impairment may be attenuated with omega-3 fatty acid supplementation: A randomised controlled pilot …
telomere shortening in endothelial and progenitor cells likely to play a crucial role in the development of vascular disease
telomere shortening in familial and sporadic pulmonary fibrosis
telomere shortening in Fanconi anaemia demonstrated by a direct FISH approach
telomere shortening in formerly abused and never abused women
telomere shortening in gastric carcinoma with aging despite telomerase activation
telomere shortening in Hematological Malignancies with Tetraploidization—A Mechanism for Chromosomal Instability?
telomere shortening in hematopoietic stem cell transplantation: a potential mechanism for late graft failure?
telomere shortening in human coronary artery diseases
telomere shortening in human diseases
telomere shortening in human fibroblasts is not dependent on the size of the telomeric-3′-overhang
telomere shortening in human fibroblasts is not dependent on the size of the telomeric‐3′‐overhang
telomere shortening in human HL60 cells by treatment with 3′-azido-2′, 3′-dideoxynucleosides and telomerase inhibition by their 5′-triphosphates
telomere shortening in human HL60 cells by treatment with deoxyguanosine analogs
telomere shortening in human kidney-The key to the adverse effects of donor age?
telomere shortening in intra uterine growth restriction placentas
telomere shortening in kidneys with age
telomere shortening in leucocyte subsets of long‐term survivors of allogeneic bone marrow transplantation
telomere shortening in leukemic cells is related to their genetic alterations but not replicative capability
telomere shortening in leukocyte subpopulations from baboons
telomere shortening in leukocyte subpopulations in depression
telomere shortening in liver transplant recipients is not influenced by underlying disease or metabolic derangements.
telomere shortening in middle-aged men with sleep-disordered breathing
telomere shortening in mouse strains with constitutional chromosomal aberrations
telomere shortening in mTR−/− embryos is associated with failure to close the neural tube
telomere shortening in mucosa surrounding the tumor: biosensor of field cancerization and prognostic marker of mucosal failure in head and neck squamous cell …
telomere shortening in neural stem cells disrupts neuronal differentiation and neuritogenesis
telomere shortening in neurological disorders: an abundance of unanswered questions
telomere shortening in non-tumorous and tumor mucosa is independently related to colorectal carcinogenesis in precancerous lesions
telomere shortening in pancreatic cancer is correlated to KRAS mutation
telomere shortening in patients with plasma cell disorders
telomere shortening in peripheral blood cells was related with aging but not with white blood cell count
telomere shortening In Peripheral Skeletal Muscle Of Patient With Chronic Obstructive Pulmonary Disease
telomere shortening in Ph-negative chronic myeloproliferative neoplasms: a biological marker of polycythemia vera and myelofibrosis, regardless of …
telomere shortening in placentas from pregnancies complicated with diabetes
telomere shortening in rat hepatic stem-like epithelial cells and subcellular localization of rat PinX1
telomere shortening in recipients of bone-marrow transplants
telomere shortening in renal cell carcinoma
telomere shortening in sleep apnea syndrome
telomere shortening in smokers with and without COPD
telomere shortening in stillbirth: a sign of premature placental senescence
telomere shortening in T cells correlates with Alzheimer’s disease status
telomere shortening in T lymphocytes of older individuals with Down syndrome and dementia
telomere shortening in the Alzheimer’s disease neuroimaging initiative cohort
telomere shortening in the colonial coral Acropora digitifera during development
telomere shortening in the colonic mucosa of patients with ulcerative colitis
telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence
telomere shortening in the esophagus of Japanese alcoholics: relationships with chromoendoscopic findings, ALDH2 and ADH1B genotypes and smoking …
telomere shortening in the Oral Epithelium in Relation to Alcohol Intake, Alcohol Dehydrogenase (ADH‐1B) and Acetaldehyde Dehydrogenase (ALDH‐2) Genotypes …
telomere shortening in the pathogenesis of nasopharyngeal carcinoma
telomere shortening in type II pneumocytes relates to idiopathic pulmonary fibrosis
telomere shortening in uterine leiomyomas
telomere shortening in women resident close to waste landfill sites
telomere shortening induces cell intrinsic checkpoints and environmental alterations limiting adult stem cell function
telomere shortening is a hallmark of genetic cardiomyopathies
telomere shortening is a prognostic factor in chronic hepatitis C virus infection
telomere shortening is a sole mechanism of aging in mammals
telomere shortening is an early somatic DNA alteration in human prostate tumorigenesis
telomere shortening is an in vivo marker of myocyte replication and aging
telomere shortening is associated to TRF1 and PARP1 overexpression in Duchenne muscular dystrophy
telomere shortening is associated with cell division in vitro and in vivo
telomere shortening is associated with genetic anticipation in Chinese Von Hippel–Lindau disease families
telomere shortening is associated with malformation in p53-deficient mice after irradiation during specific stages of development
telomere shortening is associated with poor prognosis and telomerase activity correlates with DNA repair impairment in non-small cell lung cancer
telomere shortening is associated with reduced duodenal HCO3− secretory but normal gastric acid secretory capacity in aging mice
telomere shortening is correlated with the DNA damage response and telomeric protein down-regulation in colorectal preneoplastic lesions
telomere shortening is nearly universal in pancreatic intraepithelial neoplasia
telomere shortening is proportional to the size of the G-rich telomeric 3′-overhang
telomere shortening is the sole mechanism of aging
telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model
telomere shortening leads to earlier age of onset in ALS mice
telomere shortening may be associated with human keloids
telomere shortening may contribute to aging and cancer: a perspective
telomere shortening mechanisms
telomere shortening occurs early during breast tumorigenesis: a cause of chromosome destabilization underlying malignant transformation?
telomere shortening occurs early during gastrocarcinogenesis
telomere shortening occurs in Asian Indian Type 2 diabetic patients
telomere shortening occurs in subsets of normal breast epithelium as well as in situ and invasive carcinoma
telomere shortening of epithelial cells characterises the adenoma-carcinoma transition of human colorectal cancer
telomere shortening of MCF 7 Cells Caused by Antisense Telomerase cDNA
telomere shortening of MCF-7 Cells Caused by Antisense Telomerase cDNA.
telomere shortening of peripheral blood mononuclear cells in coronary disease patients with metabolic disorders
telomere shortening over 6 years is associated with increased subclinical carotid vascular damage and worse cardiovascular prognosis in the general population
telomere shortening produces an inflammatory environment that promotes tumor invasiveness in zebrafish
telomere shortening rate predicts species life span
telomere shortening reduces Alzheimer’s disease amyloid pathology in mice
telomere shortening Reduces Regenerative Capacity after Acute Kidney Injury
telomere shortening reduces Survival despite Suppression of Carcinoma Formation during Chronic Liver Damage
telomere shortening relaxes X chromosome inactivation and forces global transcriptome alterations
telomere shortening sensitizes cancer cells to selected cytotoxic agents: in vitro and in vivo studies and putative mechanisms
telomere shortening triggers a feedback loop to enhance end protection
telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments
telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21CIP1, but not p16INK4a
telomere shortening unrelated to smoking, body weight, physical activity, and alcohol intake: 4,576 general population individuals with repeat measurements …
telomere shortening with aging in human esophageal mucosa
telomere shortening with aging in human liver
telomere shortening with aging in human thyroid and parathyroid tissue
telomere shortening with aging in the human pancreas
telomere shortening, ageing, and chromosome damage
telomere shortening, atherosclerosis, and metabolic syndrome
telomere shortening, clonal evolution and disease progression in myelodysplastic syndrome patients with 5q deletion treated with lenalidomide
telomere shortening, inflammatory cytokines, and anti-cytomegalovirus antibody follow distinct age-associated trajectories in humans
telomere shortening, regenerative capacity, and cardiovascular outcomes
telomere shortening, telomerase expression, and chromosome instability in rat hepatic epithelial stem‐like cells
telomere shortening, TP53 mutations and deletions in chronic lymphocytic leukemia result in increased chromosomal instability and breakpoint clustering in …
telomere shortening: a biological marker of sporadic colorectal cancer with normal expression of p53 and mismatch repair proteins
telomere shortening: a diagnostic tool and therapeutic target for cardiovascular disease?
telomere shortening: A marker of atherosclerosis?
telomere shortening: a new prognostic factor for cardiovascular disease post-radiation exposure
telomere shortening: significant for keratinocyte grafting?
telomere shortening: The main mechanism of natural and radiation aging
telomere structure and shortening in telomerase-deficient Trypanosoma brucei
telomere Structure and Shortening in Telomerase-Deficient Trypanosoma brucei: Implications for Anitgenic Variation
telomere uncapping in progenitor cells with critical telomere shortening is coupled to S-phase progression in vivo
Telomeric noncoding RNA TERRA is induced by telomere shortening to nucleate telomerase molecules at short telomeres
TERRA promotes telomere shortening through exonuclease 1–mediated resection of chromosome ends
TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence
The aging lung: tissue telomere shortening in health and disease
The association between statins and telomere shortening
The association of occupational metals exposure and oxidative damage, telomere shortening in fitness equipments manufacturing workers
The effect of pro-inflammatory conditioning and/or high glucose on telomere shortening of aging fibroblasts
The effects of telomere shortening on cancer cells: a network model of proteomic and microRNA analysis
The interaction effects of polycyclic aromatic hydrocarbons exposure and TERT-CLPTM1L variants on longitudinal telomere length shortening: A prospective cohort …
The Pro12Ala polymorphism of the PPARγ2 gene interacts with a Mediterranean Diet to prevent telomere shortening in the PREDIMED-NAVARRA randomized trial
The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men
The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men: a novel demonstration
The role of telomere shortening in carcinogenesis: A hybrid stochastic-deterministic approach
The role of telomere shortening in somatic stem cells and tissue aging: lessons from telomerase model systems
The role of telomere shortening in the development and progression of COPD
The roles of senescence and telomere shortening in cardiovascular disease
The shortening of leukocyte telomere length relates to DNA hypermethylation of LINE-1 in type 2 diabetes mellitus
The shortening telomere length of T lymphocytes maybe associated with hyper‑function in servere aplastic anemia
The teleost Oryzias latipes shows telomere shortening with age despite considerable telomerase activity throughout life
The telomerase inhibitor telomestatin induces telomere shortening and cell death in Arabidopsis
The telomere shortening signal may be explained by a fountain mechanism modulating the expression of eukaryotic genes
The THO complex component Thp2 counteracts telomeric R‐loops and telomere shortening
The two isomers of HDTIC compounds from Astragali Radix slow down telomere shortening rate via attenuating oxidative stress and increasing DNA repair ability in …
The Yeast TEL1 Gene Partially Substitutes for Human ATM in Suppressing Hyperrecombination, Radiation-Induced Apoptosis and telomere shortening in AT Cells
Thymoquinone induces telomere shortening, DNA damage and apoptosis in human glioblastoma cells
T-loop formation and abrupt telomere shortening
Tomentosin Induces telomere shortening and Caspase‐Dependant Apoptosis in Cervical Cancer Cells
Topical application of preparations containing DNA repair enzymes prevents ultraviolet-induced telomere shortening and c-FOS proto-oncogene hyperexpression in …
TRF2 overexpression diminishes repair of telomeric single-strand breaks and accelerates telomere shortening in human fibroblasts
triphosphates inhibit telomerase activity in vitro , and the corresponding nucleosides cause telomere shortening in human HL60 cells
Two consecutive courses of peripheral blood progenitor cell (PBPC) mobilization induce marked telomere length shortening
Uncoupling the senescent phenotype from telomere shortening in hydrogen peroxide-treated fibroblasts
Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesis
Urothelial cell senescence is not linked with telomere shortening
WRN controls formation of extrachromosomal telomeric circles and is required for TRF2ΔB-mediated telomere shortening
XAV939 promotes apoptosis in a neuroblastoma cell line via telomere shortening
XPF with mutations in its conserved nuclease domain is defective in DNA repair but functions in TRF2-mediated telomere shortening
Zscan4 is activated after telomere shortening in mouse embryonic stem cells
γ-Tocotrienol prevents oxidative stress-induced telomere shortening in human fibroblasts derived from different aged individuals

Telomere Shortening & Premature Aging

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