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Proteostasis

  1. Adapting proteostasis for disease intervention
  2. Biological and chemical approaches to diseases of proteostasis deficiency
  3. Proteostasis and aging
  4. The proteostasis network and its decline in ageing
  5. The biology of proteostasis in aging and disease
  6. Pathways of cellular proteostasis in aging and disease
  7. Aging as an event of proteostasis collapse
  8. Proteostasis impairment in protein-misfolding and-aggregation diseases
  9. Quality control of mitochondrial proteostasis
  10. Proteostasis control by the unfolded protein response
  11. Proteostasis, oxidative stress and aging
  12. Molecular chaperones in protein folding and proteostasis
  13. Proteostasis in cardiac health and disease
  14. Proteostasis and longevity: when does aging really begin?
  15. Proteostasis and the aging proteome in health and disease
  16. Proteostasis impairment in ALS
  17. FoldEco: a model for proteostasis in E. coli
  18. Molecular chaperone functions in protein folding and proteostasis
  19. Cellular proteostasis in neurodegeneration
  20. Protein folding and mechanisms of proteostasis
  21. Proteostasis and aging of stem cells
  22. Walking the tightrope: proteostasis and neurodegenerative disease
  23. Small-molecule proteostasis regulators for protein conformational diseases
  24. Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases
  25. Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity
  26. Proteostasis in complex dendrites
  27. Small molecules to improve ER proteostasis in disease
  28. Insulin regulation of proteostasis and clinical implications
  29. Proteostasis in endoplasmic reticulum—new mechanisms in kidney disease
  30. Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
  31. The endolysosomal system and proteostasis: from development to degeneration
  32. Endoplasmic reticulum proteostasis impairment in aging
  33. Immunoproteasomes are important for proteostasis in immune responses
  34. Less is more: improving proteostasis by translation slow down
  35. Shaping proteostasis at the cellular, tissue, and organismal level
  36. Modeling general proteostasis: proteome balance in health and disease
  37. A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease
  38. Dysfunction of cellular proteostasis in Parkinson’s disease
  39. The UFMylation system in proteostasis and beyond
  40. Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases–progress and prognosis
  41. The contribution of the 20S proteasome to proteostasis
  42. The proteostasis boundary in misfolding diseases of membrane traffic
  43. Diversity in the origins of proteostasis networks—a driver for protein function in evolution
  44. A ribosomal perspective on proteostasis and aging
  45. Tailoring of proteostasis networks with heat shock factors
  46. Role of protein misfolding and proteostasis deficiency in protein misfolding diseases and aging
  47. Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit
  48. Extracellular chaperones and proteostasis
  49. Targeting defective proteostasis in the collagenopathies
  50. Proteostasis and REDOX state in the heart
  51. Endoplasmic reticulum proteostasis in hepatic steatosis
  52. HSF1: guardian of proteostasis in cancer
  53. Mitochondrial proteostasis in the control of aging and longevity
  54. The nascent polypeptide‐associated complex is a key regulator of proteostasis
  55. A cellular perspective on conformational disease: the role of genetic background and proteostasis networks
  56. A genetic screening strategy identifies novel regulators of the proteostasis network
  57. Nutrient‐driven O‐GlcNAc in proteostasis and neurodegeneration
  58. Systemic stress signalling: understanding the cell non-autonomous control of proteostasis
  59. Molecular chaperones and neuronal proteostasis
  60. Proteostasis and neurodegeneration: the roles of proteasomal degradation and autophagy
  61. Regulation of organismal proteostasis by transcellular chaperone signaling
  62. Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments
  63. Happily (n) ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence
  64. Targeting the proteostasis network in Huntington’s disease
  65. ER proteostasis control of neuronal physiology and synaptic function
  66. Proteostasis collapse is a driver of cell aging and death
  67. Cellular sequestrases maintain basal Hsp70 capacity ensuring balanced proteostasis
  68. Folding and misfolding of human membrane proteins in health and disease: from single molecules to cellular proteostasis
  69. Molecular chaperones and proteostasis regulation during redox imbalance
  70. Perturbed proteostasis in autism spectrum disorders
  71. Emergent properties of proteostasis in managing cystic fibrosis
  72. Impaired proteostasis during skeletal muscle aging
  73. When proteostasis goes bad: protein aggregation in the cell
  74. MISTERMINATE mechanistically links mitochondrial dysfunction with proteostasis failure
  75. Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control
  76. Proteostasis regulation by the ubiquitin system
  77. Mitochondrial proteostasis in the context of cellular and organismal health and aging
  78. Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation
  79. Critical role of proteostasis-imbalance in pathogenesis of COPD and severe emphysema
  80. The chemical biology of molecular chaperones—implications for modulation of proteostasis
  81. Cytosolic proteostasis through importing of misfolded proteins into mitochondria
  82. Mapping and exploring the collagen-I proteostasis network
  83. Role of autophagy in proteostasis: friend and foe in cardiac diseases
  84. Small heat-shock proteins: important players in regulating cellular proteostasis
  85. Ribosome-associated chaperones as key players in proteostasis
  86. BAG3-mediated proteostasis at a glance
  87. CCPG1 is a non-canonical autophagy cargo receptor essential for ER-phagy and pancreatic ER proteostasis
  88. TFEB regulates lysosomal proteostasis
  89. Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases
  90. Malfolded protein structure and proteostasis in lung diseases
  91. Hyperammonemia and proteostasis in cirrhosis
  92. Neuroendocrine coordination of mitochondrial stress signaling and proteostasis
  93. Presenilins and γ-secretase in membrane proteostasis
  94. Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration
  95. Cytosolic proteostasis networks of the mitochondrial stress response
  96. The ER proteostasis network in ALS: Determining the differential motoneuron vulnerability
  97. Long-lived species have improved proteostasis compared to phylogenetically-related shorter-lived species
  98. Embryonic stem cells: a novel paradigm to study proteostasis?
  99. The effects of proteasomal inhibition on synaptic proteostasis
  100. Loss of hepatic chaperone‐mediated autophagy accelerates proteostasis failure in aging
  101. Proteostasis disturbance in amyotrophic lateral sclerosis
  102. FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging
  103. Regulating secretory proteostasis through the unfolded protein response: from function to therapy
  104. The pathophysiology of defective proteostasis in the hypothalamus—from obesity to ageing
  105. Cross talk of proteostasis and mitostasis in cellular homeodynamics, ageing, and disease
  106. The rise of proteostasis promoters
  107. Endoplasmic reticulum proteostasis: a key checkpoint in cancer
  108. Targeting mitochondrial function and proteostasis to mitigate dynapenia
  109. Gene therapy strategies to restore ER proteostasis in disease
  110. APP metabolism regulates tau proteostasis in human cerebral cortex neurons
  111. Proteostasis of huntingtin in health and disease
  112. Redox regulation of homeostasis and proteostasis in peroxisomes
  113. Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis
  114. Targeting the proteostasis network for mycobacterial drug discovery
  115. Mitochondrial stress restores the heat shock response and prevents proteostasis collapse during aging
  116. Proteostasis in the endoplasmic reticulum: road to cure
  117. Proteostasis and beyond: ATF6 in ischemic disease
  118. Control of systemic proteostasis by the nervous system
  119. Impaired PSII proteostasis triggers a UPR-like response in the var2 mutant of Arabidopsis
  120. Ubiquitin-dependent and independent roles of SUMO in proteostasis
  121. The stop-and-go traffic regulating protein biogenesis: How translation kinetics controls proteostasis
  122. Age-related oxidative stress compromises endosomal proteostasis
  123. Loss of proteostasis is a pathomechanism in Cockayne syndrome
  124. Impaired proteostasis: role in the pathogenesis of diabetes mellitus
  125. Autophagy and proteostasis in the control of synapse aging and disease
  126. Cellular proteostasis: degradation of misfolded proteins by lysosomes
  127. Bacterial proteostasis balances energy and chaperone utilization efficiently
  128. Proteostasis in Huntington’s disease: disease mechanisms and therapeutic opportunities
  129. Host proteostasis modulates influenza evolution
  130. ER proteostasis addiction in cancer biology: Novel concepts
  131. Using pharmacological chaperones to restore proteostasis
  132. A thiol probe for measuring unfolded protein load and proteostasis in cells
  133. Impaired proteostasis in rare neurological diseases
  134. The autophagy-lysosomal pathways and their emerging roles in modulating proteostasis in tumors
  135. The role of co-chaperones in synaptic proteostasis and neurodegenerative disease
  136. A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage
  137. Proteostasis during cerebral ischemia
  138. The measurement of protein synthesis for assessing proteostasis in studies of slowed aging
  139. Proteostasis: a new therapeutic paradigm for pulmonary disease
  140. Unfolded protein response‐induced ER dj3 secretion links ER stress to extracellular proteostasis
  141. Organismal proteostasis: role of cell-nonautonomous regulation and transcellular chaperone signaling
  142. Proteostasis regulation at the endoplasmic reticulum: a new perturbation site for targeted cancer therapy
  143. The structure of the PA28–20S proteasome complex from Plasmodium falciparum and implications for proteostasis
  144. Systematic proteome and proteostasis profiling in human Trisomy 21 fibroblast cells
  145. Aging and proteins: what does proteostasis have to do with age?
  146. Activation of the endoplasmic reticulum unfolded protein response by lipid disequilibrium without disturbed proteostasis in vivo
  147. Mechanisms of cellular proteostasis: insights from single-molecule approaches
  148. Impact of high hydrostatic pressure on bacterial proteostasis
  149. Proteasome dysfunction in Drosophila signals to an Nrf2‐dependent regulatory circuit aiming to restore proteostasis and prevent premature aging
  150. Structures and functions of protein disulfide isomerase family members involved in proteostasis in the endoplasmic reticulum
  151. mTORC1 senses stresses: Coupling stress to proteostasis
  152. The proteostasis network provides targets for neurodegeneration
  153. Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria
  154. Proteostasis and ageing: insights from long‐lived mutant mice
  155. Proteostasis and movement disorders: Parkinson’s disease and amyotrophic lateral sclerosis
  156. sHSP in the eye lens: crystallin mutations, cataract and proteostasis
  157. Hspb7 is a cardioprotective chaperone facilitating sarcomeric proteostasis
  158. An intracellular pathogen response pathway promotes proteostasis in C. elegans
  159. Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis
  160. Impact of tRNA modifications and tRNA-modifying enzymes on proteostasis and human disease
  161. Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice
  162. Aberrant proteostasis of BMAL1 underlies circadian abnormalities in a paradigmatic mTOR-opathy
  163. Dietary restriction improves proteostasis and increases life span through endoplasmic reticulum hormesis
  164. Hypoxia disrupts proteostasis in Caenorhabditis elegans
  165. Role of mTORC1 controlling proteostasis after brain ischemia
  166. NMNAT2: HSP90 complex mediates proteostasis in proteinopathies
  167. Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles
  168. The RAB GTPase RAB18 modulates macroautophagy and proteostasis
  169. Mutant huntingtin disrupts mitochondrial proteostasis by interacting with TIM23
  170. Activin Signaling Targeted by Insulin/dFOXO Regulates Aging and Muscle Proteostasis in Drosophila
  171. Proteostasis in the Hedgehog signaling pathway
  172. Innovative strategies to treat protein misfolding in inborn errors of metabolism: pharmacological chaperones and proteostasis regulators
  173. Coupling of ribostasis and proteostasis: Hsp70 proteins in mRNA metabolism
  174. Mechanisms of protein homeostasis (proteostasis) maintain stem cell identity in mammalian pluripotent stem cells
  175. Defining the essential function of yeast Hsf1 reveals a compact transcriptional program for maintaining eukaryotic proteostasis
  176. Ammonia lowering reverses sarcopenia of cirrhosis by restoring skeletal muscle proteostasis
  177. Keeping up the balance: role of HDACs in cardiac proteostasis and therapeutic implications for atrial fibrillation
  178. Germline stem cell arrest inhibits the collapse of somatic proteostasis early in Caenorhabditis elegans adulthood
  179. Targeting viral proteostasis limits influenza virus, HIV, and dengue virus infection
  180. Expanding the organismal proteostasis network: Linking systemic stress signaling with the innate immune response
  181. A Screenable in vivo Assay to Study Proteostasis Networks in Caenorhabditis elegans
  182. Defective proteostasis in celiac disease as a new therapeutic target
  183. Therapeutic strategies to correct proteostasis-imbalance in chronic obstructive lung diseases
  184. Mitochondrial DNA polymorphisms specifically modify cerebral β-amyloid proteostasis
  185. Resveratrol induces brain resilience against Alzheimer neurodegeneration through proteostasis enhancement
  186. The unfolded protein response and proteostasis in Alzheimer disease: preferential activation of autophagy by endoplasmic reticulum stress
  187. A critical appraisal of quantitative studies of protein degradation in the framework of cellular proteostasis
  188. Prions, chaperones, and proteostasis in yeast
  189. Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis
  190. Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer’s disease neuropathology: redox proteomics analysis of human …
  191. Deconvoluting stress-responsive proteostasis signaling pathways for pharmacologic activation using targeted RNA sequencing
  192. Mitophagy in maintaining skeletal muscle mitochondrial proteostasis and metabolic health with ageing
  193. A biosensor-based framework to measure latent proteostasis capacity
  194. Proteostasis, an emerging therapeutic paradigm for managing inflammatory airway stress disease
  195. Progressing neurobiological strategies against proteostasis failure: Challenges in neurodegeneration
  196. To adapt or not to adapt: consequences of declining adaptive homeostasis and proteostasis with age
  197. Fluorodeoxyuridine Improves Caenorhabditis elegans Proteostasis Independent of Reproduction Onset
  198. Manipulating proteostasis to repair the F508del-CFTR defect in cystic fibrosis
  199. Rbfox splicing factors maintain skeletal muscle mass by regulating calpain3 and proteostasis
  200. The STI and UBA domains of UBQLN1 are critical determinants of substrate interaction and proteostasis
  201. Age-related changes in the proteostasis network in the brain of the naked mole-rat: implications promoting healthy longevity
  202. Heat shock protein–inducing compounds as therapeutics to restore Proteostasis in atrial fibrillation
  203. Flagging and docking: dual roles for N-glycans in protein quality control and cellular proteostasis
  204. Expanding proteostasis by membrane trafficking networks
  205. Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation
  206. ER proteostasis disturbances in Parkinson’s disease: novel insights
  207. Role of nerve–muscle interactions and reactive oxygen species in regulation of muscle proteostasis with ageing
  208. Chaperone proteostasis in Parkinson’s disease: Stabilization of the Hsp70/α‐synuclein complex by Hip
  209. PRMT5 modulates splicing for genome integrity and preserves proteostasis of hematopoietic stem cells
  210. The ubiquitin ligase CHIP integrates proteostasis and aging by regulation of insulin receptor turnover
  211. Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling
  212. Uncoupling proteostasis and development in vitro with a small molecule inhibitor of the pancreatic endoplasmic reticulum kinase, PERK
  213. FOXO3 directly regulates an autophagy network to functionally regulate proteostasis in adult neural stem cells
  214. Proteostasis and “redoxtasis” in the secretory pathway: tales of tails from ERp44 and immunoglobulins
  215. Inflammasome activation by altered proteostasis
  216. Cellular proteostasis during influenza A virus infection—friend or foe?
  217. Pharmaceutical chaperones and proteostasis regulators in the therapy of lysosomal storage disorders: current perspective and future promises
  218. Adapting proteostasis and autophagy for controlling the pathogenesis of cystic fibrosis lung disease
  219. Sphingolipid modulation activates proteostasis programs to govern human hematopoietic stem cell self-renewal
  220. Palmitoylation enables MAPK-dependent proteostasis of axon survival factors
  221. ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer’s disease
  222. Mitochondrial proteostasis as a shared characteristic of slowed aging: the importance of considering cell proliferation
  223. Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms
  224. The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington’s disease patients
  225. Proteostasis by STUB1/HSP70 complex controls sensitivity to androgen receptor targeted therapy in advanced prostate cancer
  226. Altered proteostasis in aging and heat shock response in C. elegans revealed by analysis of the global and de novo synthesized proteome
  227. Endoplasmic reticulum proteostasis control and gastric cancer
  228. Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signalling
  229. Linking cellular proteostasis to yeast longevity
  230. Disease-relevant proteostasis regulation of cystic fibrosis transmembrane conductance regulator
  231. Non-enzymatic post-translational protein modifications and proteostasis network deregulation in carcinogenesis
  232. Mevalonate pathway regulates cell size homeostasis and proteostasis through autophagy
  233. Proteostasis and ALS: protocol for a phase II, randomised, double-blind, placebo-controlled, multicentre clinical trial for colchicine in ALS (Co-ALS)
  234. Adapt, recycle, and move on: proteostasis and trafficking mechanisms in melanoma
  235. Immunoproteasome inhibition impairs T and B cell activation by restraining ERK signaling and proteostasis
  236. Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan
  237. Proteasome‐mediated proteostasis: Novel medicinal and pharmacological strategies for diseases
  238. Proteostasis and mitochondrial role on psychiatric and neurodegenerative disorders: current perspectives
  239. Proteostasis in cerebral small vessel disease
  240. Selenoprotein T is a key player in ER proteostasis, endocrine homeostasis and neuroprotection
  241. Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells
  242. JNK modifies neuronal metabolism to promote proteostasis and longevity
  243. SUMOylation and the HSF1-regulated chaperone network converge to promote proteostasis in response to heat shock
  244. A homeostatic shift facilitates endoplasmic reticulum proteostasis through transcriptional integration of proteostatic stress response pathways
  245. Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice
  246. CCPG1, a cargo receptor required for reticulophagy and endoplasmic reticulum proteostasis
  247. Spindle assembly checkpoint robustness requires Tpr-mediated regulation of Mad1/Mad2 proteostasis
  248. Nrf2 mitigates LRRK2-and α-synuclein–induced neurodegeneration by modulating proteostasis
  249. Clp protease and OR directly control the proteostasis of phytoene synthase, the crucial enzyme for carotenoid biosynthesis in Arabidopsis
  250. Conditional protein function via N-degron pathway–mediated proteostasis in stress physiology
  251. Spatial quality control bypasses cell-based limitations on proteostasis to promote prion curing
  252. Chaperone-assisted proteostasis is essential for mechanotransduction in mammalian cells
  253. Fatty acid and lipopolysaccharide effect on beta cells proteostasis and its impact on insulin secretion
  254. Protein aggregates and proteostasis in aging: amylin and β-cell function
  255. The nucleolus as a proteostasis regulator
  256. Regulating extracellular proteostasis capacity through the unfolded protein response
  257. Proteostasis and RNA binding proteins in synaptic plasticity and in the pathogenesis of neuropsychiatric disorders
  258. Proteome dynamics: tissue variation in the kinetics of proteostasis in intact animals
  259. p53 is a master regulator of proteostasis in SMARCB1-deficient malignant rhabdoid tumors
  260. A plastic SQSTM1/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells
  261. mTOR/AMPK signaling in the brain: Cell metabolism, proteostasis and survival
  262. The chaperonin TRiC/CCT associates with prefoldin through a conserved electrostatic interface essential for cellular proteostasis
  263. A non-BRICHOS SFTPC mutant (SP-CI73T) linked to interstitial lung disease promotes a late block in macroautophagy disrupting cellular proteostasis and …
  264. A Differentiation Transcription Factor Establishes Muscle-Specific Proteostasis in Caenorhabditis elegans
  265. Proteostasis modulators prolong missense VHL protein activity and halt tumor progression
  266. Gold nanourchins induce cellular stress, impair proteostasis and damage RNA
  267. Gambogic acid triggers vacuolization-associated cell death in cancer cells via disruption of thiol proteostasis
  268. Maintenance of proteostasis by P body-mediated regulation of eIF4E availability during aging in Caenorhabditis elegans
  269. Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function
  270. Vulnerability of newly synthesized proteins to proteostasis stress
  271. MitoCPR: Meticulous monitoring of mitochondrial proteostasis
  272. Improved proteostasis in the secretory pathway rescues Alzheimer’s disease in the mouse
  273. A new Drosophila model of Ubiquilin knockdown shows the effect of impaired proteostasis on locomotive and learning abilities
  274. Exercise prevents impaired autophagy and proteostasis in a model of neurogenic myopathy
  275. Proteostasis in striatal cells and selective neurodegeneration in Huntington’s disease
  276. Proteostasis environment shapes higher-order epistasis operating on antibiotic resistance
  277. A quantitative and temporal map of proteostasis during heat shock in Saccharomyces cerevisiae
  278. Proteostasis and the regulation of intra-and extracellular protein aggregation by ATP-independent molecular chaperones: lens α-crystallins and milk caseins
  279. Proteostasis in pediatric pulmonary pathology
  280. SMPD3 deficiency perturbs neuronal proteostasis and causes progressive cognitive impairment
  281. Oxidative stress, mitochondrial and proteostasis malfunction in adrenoleukodystrophy: a paradigm for axonal degeneration
  282. J protein mutations and resulting proteostasis collapse
  283. Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1
  284. Variable repeats in the eukaryotic polyubiquitin gene ubi4 modulate proteostasis and stress survival
  285. Protein folding and the challenges of maintaining endoplasmic reticulum proteostasis in idiopathic pulmonary fibrosis
  286. Unravelling druggable signalling networks that control F508del-CFTR proteostasis
  287. The ribosome-bound quality control complex: from aberrant peptide clearance to proteostasis maintenance
  288. Unraveling the structure and dynamics of the human DNAJB6b chaperone by NMR reveals insights into Hsp40-mediated proteostasis
  289. Amelioration of mitochondrial quality control and proteostasis by natural compounds in Parkinson’s disease models
  290. Oxidative stress and proteostasis network: culprit and casualty of Alzheimer’s-like neurodegeneration
  291. Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy
  292. HSF1 stress response pathway regulates autophagy receptor SQSTM1/p62-associated proteostasis
  293. Thermal Shock Induces Host Proteostasis Disruption and Endoplasmic Reticulum Stress in the Model Symbiotic Cnidarian Aiptasia
  294. KPNB1 inhibition disrupts proteostasis and triggers unfolded protein response-mediated apoptosis in glioblastoma cells
  295. Repair or destruction—an intimate liaison between ubiquitin ligases and molecular chaperones in proteostasis
  296. Impaired PSII proteostasis promotes retrograde signaling via salicylic acid
  297. Loss of proteostasis induced by amyloid beta peptide in brain endothelial cells
  298. Adapting secretory proteostasis and function through the unfolded protein response
  299. Prion proteostasis: Hsp104 meets its supporting cast
  300. UCHL3 regulates topoisomerase-induced chromosomal break repair by controlling TDP1 proteostasis
  301. Osmotic stress–induced defective glial proteostasis contributes to brain demyelination after hyponatremia treatment
  302. Epigenetic inheritance of proteostasis and ageing
  303. A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis
  304. Lipid assemblies at the crossroads of aging, proteostasis, and neurodegeneration
  305. Tau protein aggregates inhibit the protein-folding and vesicular trafficking arms of the cellular proteostasis network
  306. PROTEOSTASIS: A European network to break barriers and integrate science on protein homeostasis
  307. Physiology and pathology of proteostasis in the early secretory compartment
  308. Caenorhabditis elegans as a model system to study intercompartmental proteostasis: Interrelation of mitochondrial function, longevity, and neurodegenerative …
  309. Combination of correctors rescues CFTR transmembrane-domain mutants by mitigating their interactions with proteostasis
  310. The function of small heat-shock proteins and their implication in proteostasis
  311. Titanium dioxide nanoparticles induce proteostasis disruption and autophagy in human trophoblast cells
  312. Intracellular crowding by age-dependent neuromelanin accumulation disrupts neuronal proteostasis and triggers Parkinson disease pathology
  313. Proteostasis: bad news and good news from the endoplasmic reticulum
  314. Partial failure of proteostasis systems counteracting TDP-43 aggregates in neurodegenerative diseases
  315. Early-age-related changes in proteostasis augment immunopathogenesis of sepsis and acute lung injury
  316. HSP60-regulated mitochondrial proteostasis and protein translation promote tumor growth of ovarian cancer
  317. Peroxisomal proteostasis involves a Lon family protein that functions as protease and chaperone
  318. Nε-lysine acetylation in the endoplasmic reticulum–a novel cellular mechanism that regulates proteostasis and autophagy
  319. SAHA enhances proteostasis of epilepsy-associated α1 (A322D) β2γ2 GABAA receptors
  320. Natural products as modulators of the proteostasis machinery: implications in neurodegenerative diseases
  321. Induction of the immunoproteasome subunit Lmp7 links proteostasis and immunity in α-synuclein aggregation disorders
  322. Diet-derived advanced glycation end products or lipofuscin disrupts proteostasis and reduces life span in Drosophila melanogaster
  323. A novel pulse-chase SILAC strategy measures changes in protein decay and synthesis rates induced by perturbation of proteostasis with an Hsp90 inhibitor
  324. Create and preserve: proteostasis in development and aging is governed by Cdc48/p97/VCP
  325. Expression of FSHD‐related DUX4‐FL alters proteostasis and induces TDP‐43 aggregation
  326. PERK signaling regulates extracellular proteostasis of an amyloidogenic protein during endoplasmic reticulum stress
  327. Changes in the turnover of the cellular proteome during metabolic reprogramming: A role for mtROS in proteostasis
  328. Impaired capacity to restore proteostasis in the aged brain after ischemia: Implications for translational brain ischemia research
  329. Defective collagen proteostasis and matrix formation in the pathogenesis of lysosomal storage disorders
  330. Compensatory increases of select proteostasis networks after Hsp70 inhibition in cancer cells
  331. Interrelation between protein synthesis, proteostasis and life span
  332. Emergent properties of proteostasis-COPII coupled systems in human health and disease
  333. On the relationship between energy metabolism, proteostasis, aging and Parkinson’s disease: possible causative role of methylglyoxal and alleviative …
  334. Cigarette smoke-induced proteostasis imbalance in obstructive lung diseases
  335. Plastid proteostasis and heterologous protein accumulation in transplastomic plants
  336. Aging attenuates redox adaptive homeostasis and proteostasis in female mice exposed to traffic-derived nanoparticles (‘vehicular smog’)
  337. Downregulation of HSP60 disrupts mitochondrial proteostasis to promote tumorigenesis and progression in clear cell renal cell carcinoma
  338. Repurposing proteostasis-modifying drugs to prevent or treat age-related dementia: a systematic review
  339. Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation
  340. Type ii epithelial-mesenchymal transition upregulates protein n-glycosylation to maintain proteostasis and extracellular matrix production
  341. Roles of the nucleotide exchange factor and chaperone Hsp110 in cellular proteostasis and diseases of protein misfolding
  342. The mevalonate pathway as a metabolic requirement for autophagy–implications for growth control, proteostasis, and disease
  343. Role of the Nervous System in the Control of Proteostasis during Innate Immune Activation: Insights from C. elegans
  344. Proteostasis Strategies for Restoring α1-Antitrypsin Deficiency
  345. Regulation of cell-non-autonomous proteostasis in metazoans
  346. Derailed proteostasis as a determinant of cardiac aging
  347. Mediation of organismal aging and somatic proteostasis by the germline
  348. Critical roles of dual-specificity phosphatases in neuronal proteostasis and neurological diseases
  349. HDAC6 suppresses age-dependent ectopic fat accumulation by maintaining the proteostasis of PLIN2 in Drosophila
  350. Proteostasis regulators and pharmacologic chaperones synergize to correct protein misfolding diseases
  351. The role of Yca1 in proteostasis. Yca1 regulates the composition of the insoluble proteome
  352. Drug repurposing to target proteostasis and prevent neurodegeneration: accelerating translational efforts
  353. Remodeling the endoplasmic reticulum proteostasis network restores proteostasis of pathogenic GABAA receptors
  354. Remodeling of proteostasis upon transition to adulthood is linked to reproduction onset
  355. Caloric restriction induces microRNAs to improve mitochondrial proteostasis
  356. CYLD regulates centriolar satellites proteostasis by counteracting the E3 ligase MIB1
  357. Mitochondrial matrix proteostasis is linked to hereditary paraganglioma: LON‐mediated turnover of the human flavinylation factor SDH5 is regulated by its interaction …
  358. Insulin/IGF1 signalling mediates the effects of β2‐adrenergic agonist on muscle proteostasis and growth
  359. Gp78 E3 ubiquitin ligase: essential functions and contributions in proteostasis
  360. Proteostasis is essential during cochlear development for neuron survival and hair cell polarity
  361. Candidate-based screening via gene modulation in human neurons and astrocytes implicates FERMT2 in Aβ and TAU proteostasis
  362. Reconstitution of a Mycobacterium tuberculosis proteostasis network highlights essential cofactor interactions with chaperone DnaK
  363. BAG3 plays a central role in proteostasis in the heart
  364. Curcumin improves palmitate-induced insulin resistance in human umbilical vein endothelial cells by maintaining proteostasis in endoplasmic reticulum
  365. Pharmaceutical inhibition of mTOR in the common marmoset: effect of rapamycin on regulators of proteostasis in a non-human primate
  366. An engineered, quantifiable in vitro model for analysing the effect of proteostasis-targeting drugs on tissue physical properties
  367. Modest overexpression of FOXO maintains cardiac proteostasis and ameliorates age‐associated functional decline
  368. The struggle by Caenorhabditis elegans to maintain proteostasis during aging and disease
  369. Novel α-tubulin mutation disrupts neural development and tubulin proteostasis
  370. dFOXO activates large and small heat shock protein genes in response to oxidative stress to maintain proteostasis in Drosophila
  371. ATP13A2/PARK9 regulates endo-/lysosomal cargo sorting and proteostasis through a novel PI (3, 5) P2-mediated scaffolding function
  372. Assembly of proteins by free RNA during the early phase of proteostasis stress
  373. Nuclear inclusion bodies of mutant and wild‐type p53 in cancer: a hallmark of p53 inactivation and proteostasis remodelling by p53 aggregation
  374. The Plastid and Mitochondrial Peptidase Network in Arabidopsis thaliana: A Foundation for Testing Genetic Interactions and Functions in Organellar Proteostasis
  375. CHIP as a membrane-shuttling proteostasis sensor
  376. Role of altered proteostasis network in chronic hypobaric hypoxia induced skeletal muscle atrophy
  377. Mechanisms of L-serine neuroprotection in vitro include er proteostasis regulation
  378. The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation
  379. Oxidative protein modification alters proteostasis under acute hypobaric hypoxia in skeletal muscles: a comprehensive in vivo study
  380. Genome-wide RNAi screen for fat regulatory genes in C. elegans identifies a proteostasis-AMPK axis critical for starvation survival
  381. SAGA DUBm-mediated surveillance regulates prompt export of stress-inducible transcripts for proteostasis
  382. Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of …
  383. Longitudinal measures of proteostasis in live neurons: features that determine fate in models of neurodegenerative disease
  384. Exosomes and STUB1/CHIP cooperate to maintain intracellular proteostasis
  385. Global and local mechanisms sustain axonal proteostasis of transmembrane proteins
  386. Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocation
  387. Aqueous extracts of Paeonia suffruticosa modulates mitochondrial proteostasis by reactive oxygen species-induced endoplasmic reticulum stress in pancreatic cancer …
  388. Loss of the novel Vcp (valosin containing protein) interactor Washc4 interferes with autophagy-mediated proteostasis in striated muscle and leads to myopathy in vivo
  389. ER strikes again: proteostasis dysfunction in ALS
  390. Characterization of the Proteostasis Roles of Glycerol Accumulation, Protein Degradation and Protein Synthesis during Osmotic Stress in C. elegans
  391. Ophiobolin A kills human glioblastoma cells by inducing endoplasmic reticulum stress via disruption of thiol proteostasis
  392. VAMP-associated proteins (VAP) as receptors that couple cystic fibrosis transmembrane conductance regulator (CFTR) proteostasis with lipid homeostasis
  393. PPARGC1A/PGC-1α, TFEB and enhanced proteostasis in Huntington disease: Defining regulatory linkages between energy production and protein–organelle quality …
  394. Roscovitine is a proteostasis regulator that corrects the trafficking defect of F 508del‐CFTR by a CDK‐independent mechanism
  395. DEG10 contributes to mitochondrial proteostasis, root growth, and seed yield in Arabidopsis
  396. Polylysine is a proteostasis network-engaging structural determinant
  397. Integrative quantitative proteomics unveils proteostasis imbalance in human hepatocellular carcinoma developed on nonfibrotic livers
  398. Proteostasis and SUMO in the heart
  399. Proteasome β5 subunit overexpression improves proteostasis during aging and extends lifespan in Drosophila melanogaster
  400. Ca2+ Homeostasis Modulation Enhances the Amenability of L444P Glucosylcerebrosidase to Proteostasis Regulation in Patient-Derived Fibroblasts
  401. Ryanodine receptor antagonists adapt NPC1 proteostasis to ameliorate lipid storage in Niemann–Pick type C disease fibroblasts
  402. iTRAQ-based analysis of progerin expression reveals mitochondrial dysfunction, reactive oxygen species accumulation and altered proteostasis
  403. Control of anterior GR adient 2 (AGR 2) dimerization links endoplasmic reticulum proteostasis to inflammation
  404. Restoration of Proteostasis in the Endoplasmic Reticulum Reverses an Inflammation-Like Response to Cytoplasmic DNA in Caenorhabditis elegans
  405. Compromised mutant EFEMP1 secretion associated with macular dystrophy remedied by proteostasis network alteration
  406. Cranberry Extract Standardized for Proanthocyanidins Alleviates β-Amyloid Peptide Toxicity by Improving Proteostasis Through HSF-1 in Caenorhabditis elegans …
  407. Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis
  408. In Vivo Interaction Proteomics Reveal a Novel p38 Mitogen-Activated Protein Kinase/Rack1 Pathway Regulating Proteostasis in Drosophila Muscle
  409. The metacaspase Yca1 maintains proteostasis through multiple interactions with the ubiquitin system
  410. Enhanced ER proteostasis and temperature differentially impact the mutational tolerance of influenza hemagglutinin
  411. Endoplasmic reticulum proteostasis influences the oligomeric state of an amyloidogenic protein secreted from mammalian cells
  412. Recurrent background mutations in WHI2 impair proteostasis and degradation of misfolded cytosolic proteins in Saccharomyces cerevisiae
  413. Altered organization of the intermediate filament cytoskeleton and relocalization of proteostasis modulators in cells lacking the ataxia protein sacsin
  414. A Novel mouse model of enhanced proteostasis: Full-length human heat shock factor 1 transgenic mice
  415. Targeting proteostasis and autophagy in SMARCB1-deficient malignancies: where next?
  416. NFκB mitigates the pathological effects of misfolded α1-antitrypsin by activating autophagy and an integrated program of proteostasis mechanisms
  417. Differential roles of the thylakoid lumenal Deg protease homologs in chloroplast proteostasis
  418. Molecular chaperones: from proteostasis to pathogenesis
  419. 2D DIGE based proteomics study of erythrocyte cytosol in sickle cell disease: altered proteostasis and oxidative stress
  420. Proteostasis network deregulation signatures as biomarkers for pharmacological disease intervention
  421. Aggregation of human S100A8 and S100A9 amyloidogenic proteins perturbs proteostasis in a yeast model
  422. Aqueous extract of Polygonum bistorta modulates proteostasis by ROS-induced ER stress in human hepatoma cells
  423. Remodeling the proteostasis network to rescue glucocerebrosidase variants by inhibiting ER-associated degradation and enhancing ER folding
  424. Special Issue on “Proteostasis and Autophagy”
  425. Modulating proteostasis: peptidomimetic inhibitors and activators of protein folding
  426. Modulation of protein synthesis and degradation maintains proteostasis during yeast growth at different temperatures
  427. Review and literature mining on proteostasis factors and cancer
  428. Resveratrol attenuates copper-induced senescence by improving cellular proteostasis
  429. Phosphorylation dependent proteostasis of sterol regulatory element binding proteins
  430. Neuroinflammation alters cellular proteostasis by producing endoplasmic reticulum stress, autophagy activation and disrupting ERAD activation
  431. Neuroinflammation and proteostasis are modulated by endogenously biosynthesized neuroprotectin D1
  432. Balancing the Photoreceptor proteome: proteostasis network therapeutics for inherited retinal disease
  433. Molecular targets for modulating the protein translation vital to proteostasis and neuron degeneration in Parkinson’s disease
  434. Hyperactivation of the insulin signaling pathway improves intracellular proteostasis by coordinately up-regulating the proteostatic machinery in adipocytes
  435. Overexpression of pink1 or parkin in indirect flight muscles promotes mitochondrial proteostasis and extends lifespan in Drosophila melanogaster
  436. FKBP10 depletion enhances glucocerebrosidase proteostasis in Gaucher disease fibroblasts
  437. Proteostasis as a therapeutic target in glomerular injury associated with mutant α-actinin-4
  438. Multiple myeloma proteostasis can be targeted via translation initiation factor eIF4E
  439. Manipulating proteostasis
  440. The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy
  441. Enhanced proteostasis in post-ischemic stroke mouse brains by ubiquilin-1 promotes functional recovery
  442. Molecular chaperones as therapeutic targets to counteract proteostasis defects
  443. Failed mitochondrial import and impaired proteostasis trigger SUMOylation of mitochondrial proteins
  444. Dendrimer-based selective proteostasis-inhibition strategy to control NSCLC growth and progression
  445. Possible mechanisms by which stefin B could regulate proteostasis and oxidative stress
  446. Modulation of the Proteostasis Machinery to Overcome Stress Caused by Diminished Levels of t6A‐Modified tRNAs in Drosophila
  447. Toxicant-mediated redox control of proteostasis in neurodegeneration
  448. Sigma-1 receptor activation induces autophagy and increases proteostasis capacity in vitro and in vivo
  449. Coffee extract and caffeine enhance the heat shock response and promote proteostasis in an HSF-1-dependent manner in Caenorhabditis elegans
  450. (Poly) phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis
  451. Quantitative proteomics of rat livers shows that unrestricted feeding is stressful for proteostasis with implications on life span
  452. The therapeutic effects of 4-phenylbutyric acid in maintaining proteostasis
  453. Alpha-fetoprotein is a biomarker of unfolded protein response and altered proteostasis in hepatocellular carcinoma cells exposed to sorafenib
  454. Resveratrol reduces amyloid-beta (Aβ1–42)-induced paralysis through targeting proteostasis in an Alzheimer model of Caenorhabditis elegans
  455. CCPG1 is a noncanonical autophagy cargo receptor essential for reticulophagy and pancreatic ER proteostasis
  456. Sorting out how Msp1 maintains mitochondrial membrane proteostasis
  457. Activation of histone deacetylase-6 induces contractile dysfunction through derailment of α-tubulin proteostasis in experimental and human atrial fibrillation
  458. Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregation
  459. Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans
  460. TRNA mutations that affect decoding fidelity deregulate development and the proteostasis network in zebrafish
  461. Proteostasis maintenance of Cys-loop receptors
  462. Neuronal XBP-1 activates intestinal lysosomes to improve proteostasis in C. elegans
  463. SIL1, the endoplasmic-reticulum-localized BiP co-chaperone, plays a crucial role in maintaining skeletal muscle proteostasis and physiology
  464. Anti-prion Protein Antibody 6D11 Restores Cellular Proteostasis of Prion Protein Through Disrupting Recycling Propagation of PrP Sc and Targeting PrP Sc for …
  465. Agents that stabilize mutated von Hippel–Lindau (VHL) protein: results of a high-throughput screen to identify compounds that modulate VHL proteostasis
  466. Proteostasis takes center stage in pulmonary fibrosis
  467. How is proteinuric diabetic nephropathy caused by disturbed proteostasis and autophagy in podocytes?
  468. The burden of trisomy 21 disrupts the proteostasis network in Down syndrome
  469. Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function
  470. Blocking TGF-β signaling pathway preserves mitochondrial proteostasis and reduces early activation of PDGFRβ+ pericytes in aristolochic acid induced acute …
  471. Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis
  472. Cross‐compartment proteostasis regulation during redox imbalance induced ER stress
  473. Worming our way to novel drug discovery with the Caenorhabditis elegans proteostasis network, stress response and insulin-signaling pathways
  474. Thermophilic adaptation in prokaryotes is constrained by metabolic costs of proteostasis
  475. Proteomic analysis of eIF5B silencing-modulated proteostasis
  476. The case for therapeutic proteostasis modulators
  477. Combined inhibition of Hsp90 and the proteasome affects NSCLC proteostasis and attenuates cell migration
  478. The insulin/IGF signaling cascade modulates SUMOylation to regulate aging and proteostasis in Caenorhabditis elegans
  479. Caloric restriction rescues yeast cells from alpha-synuclein toxicity through autophagic control of proteostasis
  480. Absence of collagen XVIII in mice causes age-related insufficiency in retinal pigment epithelium proteostasis
  481. Overview: the modulation of ageing through altered proteostasis
  482. P97/CDC-48: proteostasis control in tumor cell biology
  483. Novel modulators of proteostasis: RNAi screen of chromosome I in a heat stress paradigm in C. elegans
  484. Cross-species functional modules link proteostasis to human normal aging
  485. Can correcting the ΔF508-CFTR proteostasis-defect rescue CF lung disease?
  486. The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis
  487. A chemical genetic screen reveals a role for proteostasis in capsule and biofilm formation by Cryptococcus neoformans
  488. Healthy ageing through regulated proteostasis
  489. Effect of oxygen tension on bioenergetics and proteostasis in young and old myoblast precursor cells
  490. Modulation of proteostasis counteracts oxidative stress and affects DNA base excision repair capacity in ATM-deficient cells
  491. New roles for OMA1 metalloprotease: From mitochondrial proteostasis to metabolic homeostasis
  492. Endoplasmic reticulum Ca 2+ increases enhance mutant glucocerebrosidase proteostasis
  493. Dietary-induced signals that activate the gonadal longevity pathway during development regulate a proteostasis switch in Caenorhabditis elegans adulthood
  494. A PQM-1-mediated response triggers transcellular chaperone signaling and regulates organismal proteostasis
  495. SerpinB2 (PAI-2) modulates proteostasis via binding misfolded proteins and promotion of cytoprotective inclusion formation
  496. Perturbation of cellular proteostasis networks identifies pathways that modulate precursor and intermediate but not mature levels of frataxin
  497. MDT-15/MED15 permits longevity at low temperature via enhancing lipidostasis and proteostasis
  498. Proteostasis collapse, inter-tissue communication, and the regulation of aging at the organismal level
  499. Targeting the angio-proteostasis network: Combining the forces against cancer
  500. The intrinsic and extrinsic factors that contribute to proteostasis decline and pathological protein misfolding
  501. Cellular proteostasis: a new twist in the action of thymosin α1
  502. Fasting prevents hypoxia-induced defects of proteostasis in C. elegans
  503. Impaired proteostasis in senescent vascular endothelial cells: a perspective on estrogen and oxidative stress in the aging vasculature
  504. Proteostasis impairment: at the intersection between Alzheimer’s disease and diabetes
  505. Probing tumour proteostasis and the UPR with serum markers
  506. Potential influence of cyclo (his-pro) on proteostasis: Impact on neurodegenerative diseases
  507. Proteostasis in epicardial versus subcutaneous adipose tissue in heart failure subjects with and without diabetes
  508. Mitochondria and proteostasis: it’sa kind of MAGIC
  509. Homeostatic interplay between FoxO proteins and ER proteostasis in cancer and other diseases
  510. cindr, the Drosophila homolog of the CD2AP Alzheimer’s disease risk gene, is required for synaptic transmission and proteostasis
  511. Hsp90 maintains proteostasis of the galactose utilization pathway to prevent cell lethality
  512. Restoring podocyte proteostasis in DN
  513. Targeting the proteostasis network in rhodopsin retinitis pigmentosa
  514. Ribosome-associated chaperones act as proteostasis sentinels
  515. Role of Derlin-1 protein in proteostasis regulation of ATP-sensitive potassium channels
  516. Transglutaminase type 2 in the regulation of proteostasis
  517. Hormetic heat shock and HSF-1 overexpression improve C. elegans survival and proteostasis by inducing autophagy
  518. Abnormal Osmotic Avoidance Behavior in C. elegans Is Associated with Increased Hypertonic Stress Resistance and Improved Proteostasis
  519. Overexpression of SIRT3 disrupts mitochondrial proteostasis and cell cycle progression
  520. Targeting endoplasmic reticulum acetylation to restore proteostasis in Alzheimer’s disease
  521. (off) Targeting UPR signaling: the race toward intervening ER proteostasis
  522. The AAA ATPase Afg1 preserves mitochondrial fidelity and cellular health by maintaining mitochondrial matrix proteostasis
  523. Targeting proteostasis through the protein quality control function of the Hsp90/Hsp70-based chaperone machinery for treatment of adult onset …
  524. Proteostasis and diseases of the motor unit
  525. Mild exercise differently affects proteostasis and oxidative stress on motor areas during neurodegeneration: a comparative study of three treadmill running protocols
  526. Expression‐level dependent perturbation of cell proteostasis and nuclear morphology by aggregation‐prone polyglutamine proteins
  527. Assessing proteostasis and proteasome stress in light chain amyloidosis
  528. Beyond proteostasis: Roles of type I chaperonins in bacterial pathogenesis
  529. Quality control mechanisms of protein biogenesis: proteostasis dies hard
  530. Gene expression modulation by the linker of nucleoskeleton and cytoskeleton complex contributes to proteostasis
  531. Aberrations in proteostasis orchestrate: The genotypic and phenotypic changes in aging
  532. RESEtting proteostasis
  533. Uncoupling the trade-off between somatic proteostasis and reproduction in Caenorhabditis elegans models of polyglutamine diseases
  534. Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts
  535. RESET ing ER proteostasis: selective stress pathway hidden in the secretory route
  536. Proteostasis or aging: let the CHIPs fall where they may
  537. Genetic Interactions Between BOB1 and Multiple 26S Proteasome Subunits Suggest a Role for Proteostasis in Regulating Arabidopsis Development
  538. Post-transcriptional negative feedback regulation of proteostasis through the Dis3 ribonuclease and its disruption by polyQ-expanded Huntingtin
  539. DNAJC12: A molecular chaperone involved in proteostasis, PKU, biogenic amines metabolism and beyond?
  540. Royal jelly promotes DAF-16-mediated proteostasis to tolerate β-amyloid toxicity in C. elegans model of Alzheimer’s disease
  541. Transcriptome-wide analysis links the short-term expression of the b isoforms of TIA proteins to protective proteostasis-mediated cell quiescence response
  542. In search of a cure for proteostasis-addicted cancer: a AAA target revealed
  543. Correctors rescue CFTR mutations in nucleotide-binding domain 1 (NBD1) by modulating proteostasis
  544. The Wilms tumor protein Wt1 contributes to female fertility by regulating oviductal proteostasis
  545. HSP90 et al.: chaperome and proteostasis deregulation in human disease
  546. An iTRAQ proteomics screen reveals the effects of the MDM2 binding ligand Nutlin-3 on cellular proteostasis
  547. Gene therapy in Parkinson’s disease: targeting the endplasmic reticulum proteostasis network
  548. Role of second-hand smoke (SHS)-induced proteostasis/autophagy impairment in pediatric lung diseases
  549. Quantifying Chaperone-Mediated Transitions in the Proteostasis Network of E. coli
  550. Progress toward development of a proteostasis drug for myocilin-associated glaucoma
  551. The disruption of proteostasis in neurodegenerative disorders
  552. The inhibition of IGF‐1 signaling promotes proteostasis by enhancing protein aggregation and deposition
  553. Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of …
  554. Longevity and GAPDH stability in bivalves and mammals: a convenient marker for comparative gerontology and proteostasis
  555. Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin
  556. The regulation of proteostasis in glial cells by nucleotide receptors is key in acute neuroinflammation
  557. mTOR signaling in proteostasis and its relevance to autism spectrum disorders
  558. Quantification of Cellular Proteostasis in Live Cells by Fluorogenic Assay Using the AgHalo Sensor
  559. Lysine trimethylation regulates 78-kDa glucose-regulated protein proteostasis during endoplasmic reticulum stress
  560. Nature versus nurture: does proteostasis imbalance underlie the genetic, environmental, and age-related risk factors for Alzheimer’s disease?
  561. Proteostasis goes global
  562. Proteostasis alterations in myeloproliferative neoplasms: Oncogenic relevance and therapeutic opportunities
  563. Role of the deubiquitinating enzyme ubiquitin-specific protease-14 in proteostasis in renal cells
  564. An HSP90 co-chaperone controls circadian proteostasis
  565. A42 Reactive astrocytes promote proteostasis in huntington’s disease
  566. Heat-shock proteins and molecular chaperones: role in regulation of cellular proteostasis and stress management
  567. Mechanisms regulating proteostasis are involved in sympatric speciation of the blind mole rat, Spalax galili
  568. Proteome imbalance is linked with proteostasis decline and aggregation in aging C. elegans
  569. Low erythrocyte levels of proteasome and acyl-peptide hydrolase (APEH) activities in Alzheimer’s disease: a sign of defective proteostasis?
  570. Autophagy and Proteostasis
  571. NRF2 controls proteostasis through the transcriptional regulation of autophagy
  572. Effect of liposome-encapsulated hemoglobin resuscitation on proteostasis in small intestinal epithelium after hemorrhagic shock
  573. … loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis
  574. Impaired proteostasis contributes to renal tubular dysgenesis
  575. Redox Status and Proteostasis in Ageing and Disease
  576. Too salty for worms: hypertonic stress challenges proteostasis networks. Focus on “Hypertonic stress induces rapid and widespread protein damage in C …
  577. Proteostasis and Energetics as Proteome Hallmarks of Aging and Influenza Challenge in Pulmonary Disease
  578. Heterogeneity in heat shock response dynamics caused by translation fidelity decline and proteostasis collapse
  579. Proteostasis therapeutics
  580. Meeting Report–proteostasis in Ericeira
  581. ML346: a novel modulator of proteostasis for protein conformational diseases
  582. Evaluation of Xie et al.: Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal
  583. Alteration of the proteostasis network of plant cells promotes the post-endoplasmic reticulum trafficking of recombinant mutant (L444P) human β-glucocerebrosidase
  584. Probing the proteostasis network
  585. Cellular responses to proteostasis perturbations reveal non-optimal feedback in chaperone networks
  586. Temporally distinct regulation of pathways contributing to cardiac proteostasis during the acute and recovery phases of sepsis
  587. Geroscience From Cell-body Dynamics and Proteostasis Cooperation Supported by αB-crystallin and Human will~ A Proposal of “Body-Mind Integrative Science”
  588. Correction: Spatial quality control bypasses cell-based limitations on proteostasis to promote prion curing
  589. Fibrillin-1 mgΔlpn Marfan syndrome mutation associates with preserved proteostasis and bypass of a protein disulfide isomerase-dependent quality checkpoint
  590. Limiting influenza virus, HIV and dengue virus infection by targeting viral proteostasis
  591. Plant proteostasis: methods and protocols
  592. Author correction: dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation
  593. Semen modulated secretory activity of oviductal epithelial cells is linked to cellular proteostasis network remodeling: Proteomic insights into the early phase of …
  594. Editorial (Hot Topic: Proteostasis-Imbalance and Pathogenesis of Chronic Obstructive Lung Diseases)
  595. N-term 2017: proteostasis via the N-terminus
  596. Hsp60 and Hsp70 chaperones: Guardians of mitochondrial proteostasis
  597. Targeting the Cyclophilin domain of Ran-binding Protein 2 (Ranbp2) with novel small molecules to control the proteostasis of STAT3, hnRNPA2B1 and M-Opsin
  598. Heat shock transcription factor 1 is activated as a consequence of lymphocyte activation and regulates a major proteostasis network in T cells critical for cell division …
  599. Catalytic linkage between caspase activity and proteostasis in Archaea
  600. Stretching to understand how proteostasis and the unfolded protein response regulate lung injury
  601. The novel tumor suppressor AIRAPL regulates IGF1R proteostasis
  602. Proteostasis function and disfunction: the folding machines that maintain proteome health
  603. Modulation of proteostasis and protein trafficking: a therapeutic avenue for misfolded G protein-coupled receptors causing disease in humans
  604. HSF1 is activated as a consequence of lymphocyte activation and regulates a major proteostasis network in T cells critical for cell division during stress
  605. Erratum to “Resveratrol Attenuates Copper-Induced Senescence by Improving Cellular Proteostasis”
  606. Circadian rhythms and proteostasis in aging
  607. Proteostasis and adaptation to high temperature stress
  608. Loss of Proteostasis as a substrate for Atrial Fibrillation
  609. Proteome Aggregation Patterns Under Proteostasis Stress as Signatures for Understanding Huntington’s Disease
  610. The Discovery and Characterization of Small Molecule 20s Proteasome Activators: Implications in Proteostasis Disorders
  611. The first Autumn School on Proteostasis: from molecular mechanisms to organismal consequences
  612. Cell stress and proteostasis networks in biology, aging, and disease
  613. Alpha-1 antitrypsin deficiency: A model of alteration of protein homeostasis or proteostasis
  614. Amyloidogenic Proteins Drive Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease
  615. P12 proteostasis as a therapeutic target in glomerular injury
  616. TXLNB is a Novel Regulator of Cardiac Proteostasis
  617. Links between Aging and Proteostasis Decline in Saccharomyces cerevisiae
  618. Thiol-Based Redox Signaling: Impacts on Molecular Chaperones and Cellular Proteostasis
  619. CHIPped balance of proteostasis and longevity
  620. Inhibition of ER stress-induced autophagy preserves proteostasis and protects against cardiomyocyte dysfunction in experimental and human Atrial Fibrillation
  621. In vivo interaction proteomics reveal a novel p38MAPK/Rack1 pathway regulating proteostasis in Drosophila muscle
  622. THE DECLINE OF PROTEOSTASIS IN AGING
  623. CHIP as a membrane-shuttling proteostasis sensor
  624. Proteostasis network in Down Syndrome, The
  625. Active role of free RNA during the early phase of proteostasis stress
  626. Proteostasis in retinal pigment epithelial cells: Relevance to age-related macular degeneration
  627. Restore the Secretion and Activity of Factor VIII Mutants By Proteostasis Regulator
  628. Small molecule osmolytes can modulate proteostasis
  629. The Role of AMPK in the Regulation of Skeletal Muscle Proteostasis During Cancer Cachexia
  630. Combating Parkinson’s disease-associated toxicity by modulating proteostasis
  631. Plastid Proteostasis: Relevance of Transcription, Translation, and Post-translational Modifications
  632. Different Mutations in Cilia Preassembly Gene HEATR2 Are Associated with Variable Clinical Phenotypes and Defects in Proteostasis
  633. The endoplasmic reticulum chaperone, GRP78, protects against the adverse effects of cigarette smoke on lung cell proteostasis
  634. Proteostasis Maintenance of γ-aminobutyric Acid Type A Receptors (GABAARs)
  635. Thiol-based Misfolding: Linking Redox Balance to Cytosolic Proteostasis
  636. Signaling Pathways of Proteostasis Network Unraveled by Proteomic Approaches on the Understanding of Misfolded Protein Rescue
  637. The Role of Fatty Acids on Endoplasmic Reticulum Proteostasis in Non-Alcoholic Fatty Liver Disease
  638. Role of HSPB8 in the proteostasis network: from protein synthesis to protein degradation and beyond
  639. Type I collagen proteostasis
  640. D17 STOP, DROP, AND DIE: PROTEOSTASIS AND AUTOPHAGY IN THE LUNG: Proteasome Function In The Aging Lungs
  641. Proteostasis collapse halts G1 progression and delimits replicative lifespan
  642. Non-cell Autonomous Maintenance of Proteostasis by Molecular Chaperones and Its Molecular Mechanism
  643. … phosphate affinity chromatography (PIP chromatography) for the isolation of proteins involved in protein quality control and proteostasis mechanisms in plants
  644. Aging Skeletal Muscle Proteomics Finds Changes in Spliceosome, Immune factors, Proteostasis and Mitochondria
  645. Fasting protects against proteostasis defects induced by hypoxia
  646. Epitranscriptomics: translational regulation of metabolism, drug resistance and proteostasis during cellular stress
  647. Linking cellular proteostasis to yeast longevity
  648. The impact of proteostasis imbalance on proteome solubility
  649. Yeast FIT2 homologs mediate the crosstalk between stress response pathways and cellular proteostasis
  650. Plant Proteostasis
  651. Boosting proteostasis
  652. The role of mTORC1 in muscle proteostasis
  653. Amyloidogenic Proteins Drive Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease
  654. Neuronal Proteostasis is mediated by the switch-like expression of Heme-regulated Kinase 1, acting as both a sensor and effector
  655. D17 STOP, DROP, AND DIE: PROTEOSTASIS AND AUTOPHAGY IN THE LUNG: Non-Canonical Autophagy And The Anti-Fibrotic Effects Of Bibf-1120 In Ipf
  656. Impact of Loss of Proteostasis on Central Nervous System Disorders
  657. Surfaceome dynamics during neuronal development and synaptic plasticity reveal system-wide surfaceome reorganization independent of global proteostasis
  658. Proteostasis: Found in translation
  659. Restoring proteostasis to ameliorate disease
  660. The Yeast AIF Homolog Nde1 Integrates Signals from Metabolism and Proteostasis on the Mitochondrial Surface and Executes Cell Death
  661. Towards the quantification of the proteostasis capacity of a cell
  662. Endoplasmic reticulum proteostasis impairment in aging
  663. Regulation of cellular Hsp70: Proteostasis and aggregate management
  664. Global Quantification of Proteostasis Regulation
  665. Investigations into the mechanisms of neuronal proteostasis
  666. Molecular mechanisms regulating cellular proteostasis
  667. Compensation of select proteostasis networks after Hsp70 inhibition in cancer
  668. ER stress and lipid droplet-dependent proteostasis in response to lipid stress in yeast and a novel congenital muscular dystrophy
  669. Proteostasis and Myeloid Stem Cell Production
  670. Cellular Mechanisms of Proteostasis: Cigarette smoke-induced autophagy impairment accelerates lung aging, COPD-emphysema exacerbations and …
  671. A co-translational folding reporter to monitor proteostasis
  672. PI3K/AKT Signaling Activates HSF1 to Preserve Proteostasis and Sustain Growth
  673. 599Caenorhabditis elegans Aging is Associated with a Decline in Proteostasis
  674. N1-methyladenine safeguards against aberrant RNA-protein association during proteostasis stress
  675. Proteostasis and the aging pathways
  676. Effect of Treatment with a NRF2 Activator on In Vivo Proteostasis in Mice
  677. Hsp70: A Multi-Tasking Chaperone at the Crossroad of Cellular Proteostasis
  678. An Emergent Paradigm for Vision Research: Proteostasis, Variation and Precision Management of Human Disease
  679. The Decline of Adaptive Homeostasis & Adaptive Proteostasis in Ageing
  680. T180. Unraveling the Effect of Physiological Stress on Chaperone Mediated Autophagy-Dependent Synaptic Proteostasis
  681. Mitochondrial Proteostasis and Hypoxic Injury
  682. AJP-Cell Physiology begins a theme series on the control of the proteostasis network in health and diseases
  683. Sphingolipid Perturbation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal
  684. Endoplasmic reticulum proteostasis impairment in aging
  685. Mechanisms of Division Site Selection and Role of the ATP-Dependent Protease ClpXP in Mind Regulation and Proteostasis in E. coli
  686. Molecular probe for measuring proteostasis decline in cells
  687. Deregulated expression of the HSP40 family members Auxilin-1 and-2 is indicative of proteostasis imbalance and predicts patient outcome in Ph+ leukemia
  688. Epigenetics and proteostasis in correction of misfolding disease
  689. PROTEOSTASIS IN BUDDING YEAST
  690. Proteostasis and Aging in Saccharomyces cerevisiae-The role of a Peroxiredoxin
  691. Max Delbruck Prize in Biological Physics Talk: The Physics of Cellular Proteostasis
  692. Healthspan‐Extending Treatments Enhance Proteostasis through Reduced Cellular Proliferation
  693. Proteostasis and Senescence in the Aging Lung
  694. SAGA regulates mRNA quality control and export for proteostasis
  695. Targeting Proteostasis in Atrial Fibrillation
  696. MAINTENANCE OF PROTEOSTASIS AS A PILLAR OF SLOWED AGING: LESSONS FROM LONG-LIVED MURINE MODELS
  697. Endoplasmic reticulum, oxidative stress and their complex crosstalk in neurodegeneration: proteostasis, signaling pathways and molecular chaperones
  698. Are proteostasis defects responsible for amyotrophic lateral sclerosis?
  699. Evaluation of a novel phytochemical Nrf2 activator on cytoprotective gene expression and proteostasis in vivo
  700. Novel Genetic Modulators Regulate Healthspan by Altering Proteostasis
  701. Proteostasis perturbation destabilizes respiratory complex assembly-intermediates via aggregation of subunits
  702. Functions of The Seventeen Kilodalton Protein in Escherichia coli Proteostasis
  703. Modulation of Developmental Signaling by the Proteostasis Network
  704. Yeast Proteostasis under Acute Stress
  705. A Fluorogenic Proteostasis Sensor to Monitor Proteome Stress in Real‐Time
  706. Proteostasis and Chaperone Surveillance
  707. Adapting the Chemistry and/or Biology of Proteostasis to Ameliorate Protein Aggregation Diseases
  708. Inhibition of ER Translocation by Chaperone HSPA13 and Consequences for Proteostasis
  709. Ankyrin-B: proteostasis and impact on cardiomyocyte behaviours in H9c2 cells
  710. Respiratory chain deficiency alters cellular proteostasis and triggers Alzheimer’s disease-like tau alterations
  711. Caloric restriction rescues yeast cells from alpha-synuclein toxicity through autophagic control of proteostasis
  712. Endoplasmic reticulum proteostasis impairment in aging
  713. Chaperone-directed ubiquitylation maintains proteostasis at the expense of longevity
  714. Regulation of Functional Proteome by the Heat Shock Response and Proteostasis Network
  715. The disruption of proteostasis in neurodegenerative diseases
  716. Abstract B73: Proteostasis network modules as molecular targets for cancer therapeutics.
  717. Pharmacologic ATF6 Activation Confers Global Protection in Widespread Disease Models by Reprogramming Cellular Proteostasis
  718. Small heat shock proteins: Their role in proteostasis and neurodegeneration
  719. Proteostasis and SUMO in the heart.
  720. Age-related Decline of the Adaptive Proteostasis Gene Program in Cardiac Myocytes
  721. Translation Attenuation by Minocycline Increases Lifespan and Improves Proteostasis in Old Post-Stress-Responsive Organisms
  722. Redox Status and Proteostasis in Ageing and Disease
  723. Proteostasis disturbance in amyotrophic lateral sclerosis
  724. A confocal microscopy investigation of the release of chaperones from the endoplasmic reticulum during proteostasis stress
  725. Proteostasis function and disfunction: the delicate art of maintaining a healthy proteome
  726. Targeting proteostasis in atrial fibrillation
  727. Regulating proteostasis: a study of interactions between HSP70 proteins, HSP40 proteins, and the sigma 1 receptor
  728. Adapting Proteostasis to Ameliorate Loss‐and Gain‐of‐Function Diseases
  729. Proteostasis control by the unfolded protein response
  730. Effects of impaired proteostasis on tissue physical properties in a model of bone-like tissue formation
  731. Regulating proteostasis by a chemical genetics approach
  732. Treatment with rapamycin or rapamycin in combination with metformin contributes to mechanisms of mitochondrial proteostasis in vivo and in vitro
  733. Correction: Gene therapy in Parkinson’s disease: targeting the endoplasmic reticulum proteostasis network Valentina Castillo, Gabriela Mercado, Claudio Hetz
  734. The functional nonequivalence of α-crystallins in the lens proteostasis network
  735. Prion proteostasis
  736. Study of the endoplasmic reticulum proteostasis network during ageing
  737. Mechanistic Understanding, Biochemical Modulation, and Autophagic Degradation of Mammalian Proteasomes, and Their Pathological Implications in Proteostasis
  738. A role of SUMOylation in proteostasis, centromere integrity and the DNA damage
  739. ROLE OF CARBONYL MODIFICATIONS ON AGING-ASSOCIATED LOSS OF PROTEOSTASIS
  740. Mechanisms of cellular proteostasis: insights from single molecule approaches (226.3)
  741. Adapting Proteostasis Through Stress-Responsive Signaling
  742. The Proteostasis System in Nematodes and Baker´ s Yeast
  743. Regulating Secretory Proteostasis through the Unfolded Protein Response:[249_TD $ DIFF] From Function to Therapy
  744. Monitoring ER calcium and ER proteostasis under hypoxic conditions
  745. Coordinated Control of Proteostasis in Neuronal Stress Response and Neurodegenerative Diseases
  746. Proteostasis Modulators with Discriminating Taste
  747. The Proteostasis Function of the Saccharomyces Cerevisiae Metacaspase Yca1
  748. Chaperone network based on cellular response reveals the non-optimal response to perturbed proteostasis
  749. A Role for PI31-Mediated Proteasome Regulation in Proteostasis and Neuronal Health
  750. Distant chaperones and N-glycan signals: new mechanisms of secretory pathway proteostasis
  751. Neurodegenerative stress related mitochondrial proteostasis
  752. The transcriptome of proteostasis perturbations reveal non-optimal response in chaperone networks
  753. Interactome Changes Quantified to Identify the ER Proteostasis Network to Fight Amyloid Diseases
  754. HSP-inducing compounds as therapeutics to restore proteostasis in Atrial Fibrillation
  755. ATF6 Activation Remodels the Endoplasmic Reticulum Proteostasis Network to Restore Proteostasis of Pathogenic GABAA Receptors
  756. Monitoring Proteostasis in Populations of Living E. coli Cells at the Single-Cell Level
  757. Emergent Properties of Proteostasis in CFTR Folding and Misfolding
  758. D17 STOP, DROP, AND DIE: PROTEOSTASIS AND AUTOPHAGY IN THE LUNG: Acute Lung Injury Is Associated With Altered Proteostasis In The Lung Epithelium
  759. AGING-LINKED PROTEOSTASIS DECLINE: IMPLICATIONS FOR NEURODEGENERATIVE DISEASE
  760. Polyphenols and proteostasis: The role of heat shock response and the ubiquitin-proteasome system
  761. Understanding the role of tRNA modifying enzymes in proteostasis in human health and disease–FCT
  762. The modulation of tau proteostasis in tauopathies by NUB1/NUB1L interaction with the autophagy-lysosomal pathway
  763. RESETing ER proteostasis: Selective stress pathway hidden in the secretory route
  764. Abstract A03: Perturbation of proteostasis is lethal in SMARCB1-deficient tumors
  765. The Age-Dependent Collapse of Proteostasis: A Polyglutamine Model for Protein Misfolding Disorders
  766. Targeting proteostasis in atrial fibrillation: Molecular footprints and novel therapeutic strategies
  767. Organismal proteostasis: role of cell-nonautonomous regulation and
  768. Identifying small molecule regulators of the Proteostasis Network that enhance CFTR protein function
  769. ribosome-bound quality control complex: from aberrant peptide clearance to proteostasis maintenance
  770. Membrane Dynamics of Lipid Droplet-Mediated ER Proteostasis in the Budding Yeast, Saccharomyces cerevisiae
  771. PROTEOSTASIS OF THE TONOPLAST: SYNTHESIS, SORTING AND TURNOVER OF THE POTASSIUM CHANNEL ATTPK1
  772. Circadian control and proteostasis in NRF-2/PGC-1 alpha knock-out mice
  773. Contribution of Satellite Cells to Skeletal Muscle Proteostasis during Advanced Age and Aerobic Exercise
  774. Monitoring the Proteostasis Function of the Saccharomyces cerevisiae Metacaspase Yca1
  775. Targeting protein‐protein interactions in chaperone complexes to normalize proteostasis
  776. Abstract B40: Perturbation of proteostasis is lethal in SMARCB1-deficient tumors
  777. A39 Triad of neuronal vulnerability in huntington’s disease: huntingtin proteostasis, inclusion body formation and mitochondrial function
  778. Proteostasis Responses to Endogenous Alpha-Synuclein Aggregation in the Brain
  779. Nuclear targeting of Hsp110 modifies the proteostasis system by mobilizing latent Hsp70 chaperones
  780. Resveratrol Induces Brain Resilience Against Alzheimer Neurodegeneration Through Proteostasis Enhancement
  781. mberHappily (n) ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence
  782. Investigating the impact of small molecule ligands and the proteostasis network on protein folding inside the cell
  783. Measuring proteostasis capacity using transiently transfected bait proteins by flow cytometry
  784. Loss of proteostasis in brain vascular endothelial cells in an in vitro model of alzheimer’s disease
  785. Understanding Dysregulated Collagen‐I Proteostasis Linked to Osteogenesis Imperfecta
  786. Drug repurposing to target proteostasis and prevent neurodegeneration: accelerating translational efforts
  787. Exploring the Impact of the E. coli Proteostasis Network on the Folding Fate of Proteins with Different Intrinsic Biophysical Properties
  788. Prion initiation in vivo Requires Limitations in the Proteostasis Network
  789. A systems biology approach to the correction of Cystic Fibrosis: from building a network of proteostasis regulatory pathways to combinatorial targeting
  790. TFEB regulates lysosomal proteostasis
  791. The Role of proteases and chaperones in extracellular proteostasis
  792. Cytoprotective alpha crystallins in the regulation of RPE cell proteostasis
  793. Resveratrol induces resilience against age-related neurodegeneration through improvement of proteostasis
  794. Restoring Proteostasis via Chaperone Networks in Ageing and Neurodegenerative Disease
  795. The proteostasis of the endoplasmic reticulum and the activation of the unfolded protein response pathway in vivo
  796. Restoring Epilepsy‐Associated Mutant GABAA Receptor Proteostasis
  797. Defining the Proteostasis Network Responsible for Managing the Fate of Newly Synthesized Alpha1-Antitrypsin
  798. Results of a high-throughput screen to identify compounds that modulate VHL proteostasis.
  799. Cellular Mechanisms of Proteostasis: Ulk1-mediated autophagy plays an essential role in mitochondrial remodeling and functional regeneration of skeletal …
  800. The unfolded protein response: from regulator of proteostasis to stimulator of malignancies
  801. Glycation disrupts proteostasis and promotes neurodegenerative alterations in synucleinopathies
  802. Research Topic: Plastid Proteostasis: Relevance of Transcription, Translation, and Post-translational Modifications
  803. Absence of collagen XVIII in mice causes age-related insuffiency in retinal pigment epithelium proteostasis
  804. Autophagy, FOXO1 and proteostasis: implications for human diseases
  805. Hormetic Effects of Zerumbone in Proteostasis
  806. Lack of collagen XVIII in mice evokes age‐dependent deficiency in retinal pigment epithelium proteostasis
  807. CSIG-03. CYCLIC DEPSIPEPTIDE LIGANDS TO TARGET CO-TRANSLATIONAL TRANSLOCATION AND ER PROTEOSTASIS IN GLIOBLASTOMA CELLS
  808. Intravitreal injection of novel small molecule proteostasis regulators activates the Unfolded Protein Response in murine retina
  809. proteostasis defects by inhibition of PPP1R15A could benefit many conditions characterized by the accumulation of misfolded proteins.
  810. In vivo activation of the endoplasmic reticulum unfolded protein response without disturbed proteostasis
  811. Tau proteostasis in stress-triggered neuronal dysfunction: implications for Alzheimer´ s disease
  812. Host vs Virus: HSV has evolved to evade host antiviral mechanisms by manipulating the host proteostasis machinery
  813. A Small Molecular Activator of the ER Proteostasis Regulator, ATF6, is Beneficial in the Ischemic Heart
  814. The pivotal role of proteasome enhancement in ageing, longevity and proteostasis across species
  815. PUB127 Role of microRNAs and Proteostasis System in Diesel Exhaust Particle Induced Lung Toxicity
  816. Direct Substrate Recognition by the ATP-Dependent Chaperone Protease CLPXP and Roles in Proteostasis
  817. Nrf2‐ and PGC‐1α‐deficient mice: A novel animal model for disturbed proteostasis and RPE degeneration
  818. Targeting oncoproteins via disruption of proteostasis: Identification of oncoprotein destabilizing agents using luciferase tagged oncoproteins
  819. Reprogramming the proteostasis network to prevent the accumulation of alpha-synuclein aggregates
  820. Molecular And Cellular Networks in Critical Illness Associated Muscle Weakness: Skeletal Muscle Proteostasis in the Intensive Care Unit
  821. P436 Role of myocardial proteostasis in hypoxic tolerance: effect of chemical chaperones and er stress inducers.
  822. Modulation of Proteostasis for the Efficient Intracellular Transport of the ΔF508 Mutant of Cystic Fibrosis Transmembrane Conductance Regulator
  823. The Regulation of ER Chaperones and Proinsulin Proteostasis by Perk EIF2ALPHA Kinase
  824. Effects of different ratios of medicine dosage for isoflurane and propofol on GABAAreceptor α1sub-unit proteostasis during hypoxia injury to hippocampal neurons of …
  825. Proteostasis by HSP70/STUB1 complex regulates androgen receptor variants expression and confers resistance to enzalutamide and abiraterone
  826. p97 is Critical for Cardiac Proteostasis and Dysregulation of p97 Activity Causes Cardiomyopathy
  827. Quaternary dynamics underlie the chaperone function of Hsp27 and αB-crystallin in maintaining proteostasis
  828. Unfolded protein response coordinates autophagy in maintaining proteostasis and clonal survival of limbal stem cells under UVA stress
  829. Linking the Conformational Landscape of Huntingtin to Proteostasis and Neurotoxicity in Huntington’s Disease
  830. Loss of Sil1, an ER Co‐Chaperone, Causes an Age‐Dependent Collapse of Skeletal Muscle Proteostasis, Affecting Pathways Critical for Muscle Physiology
  831. The P5 Type ATPase Atp13A2, a Parkinson associated gene, coordinates key trafficking mechanisms involved in the maintenance of cancer cell proteostasis
  832. Proteostasis in C. elegans is maintained during extreme osmotic stress by reduced translation with resultant increases in molecular chaperone capacity
  833. D17 STOP, DROP, AND DIE: PROTEOSTASIS AND AUTOPHAGY IN THE LUNG: Autophagy Is Required For Neutrophil-Mediated Inflammation
  834. Compromised Mutant EFEMP1 Secretion Associated with Macular Dystrophy Remedied by Proteostasis Network Alteration John D. Hulleman, Shalesh Kaushal …
  835. Elucidating the mechanism of action of a small molecule proteostasis regulator with potential relevance for treatment of the lysosomal storage disease …
  836. C60 QUALITY CONTROL IN LUNG CELLS: AUTOPHAGY AND PROTEOSTASIS: Toxicity Of Carbon Nanotubes: The Role Of Autophagy
  837. Hsf1 Activation Regulates The Transcriptional Activity Of The Heat Shock And Unfolded Protein Responses Altering Myeloid Proteostasis And Driving Granulopoeisis
  838. Cardiolipin exposure on the outer mitochondrial membrane modulates α‐synuclein proteostasis in hPSC‐derived Parkinson’s Disease neurons
  839. … Small Molecule Protects Against Myocardial Ischemia and Doxorubicin-Induced Cardiomyopathy Through Heat Shock Response and Proteostasis Regulation In Vivo
  840. … : Hsf1 Activation Regulates The Transcriptional Activity Of The Heat Shock And Unfolded Protein Responses Altering Myeloid Proteostasis And Driving Granulopoeisis
  841. C60 QUALITY CONTROL IN LUNG CELLS: AUTOPHAGY AND PROTEOSTASIS: Altered Proteasome Function In Pulmonary Fibrosis
  842. C60 QUALITY CONTROL IN LUNG CELLS: AUTOPHAGY AND PROTEOSTASIS: Transcriptional Regulation Of Autophagy By Stat1
  843. D17 STOP, DROP, AND DIE: PROTEOSTASIS AND AUTOPHAGY IN THE LUNG: Epigenetic Repression Of Autophagy Machinery In Idiopathic Pulmonary Fibrosis …
  844. D17 STOP, DROP, AND DIE: PROTEOSTASIS AND AUTOPHAGY IN THE LUNG: Autophagy Regulates Mucin Expression In Chronic Airway Inflammation
  845. C60 QUALITY CONTROL IN LUNG CELLS: AUTOPHAGY AND PROTEOSTASIS: Comparison Of Liver And Lung Macroautophagy Substrate Proteomes Reveals …
  846. Regulation of Nucleocytoplasmic Partitioning and Proteostasis of Substrates and Chemokine Signaling by Ran-binding protein 2 (Ranbp2) in Thy1+-Ganglionic …
  847. C60 QUALITY CONTROL IN LUNG CELLS: AUTOPHAGY AND PROTEOSTASIS: Hypercapnia Impairs Autophagy In Human Macrophages
  848. … communication, and the regulation of aging at the organismal level. Front. Genet. 6: 80. doi: 10.3389/fgene. 2015.00080 Proteostasis collapse, inter-tissue …
  849. Ryanodine receptor antagonists adapt NPC1 proteostasis to ameliorate lipid storage in Niemann-Pick type C disease fibroblasts
  850. … Post-Translational Modification and Subcellular Localization: Results of a High Throughput Screen to Identify Compounds that Modulate VHL Proteostasis
  851. C60 QUALITY CONTROL IN LUNG CELLS: AUTOPHAGY AND PROTEOSTASIS: Regulation Of Fas Expression By Tgf-[Beta] 1 Contributes To Apoptosis Resistance …
  852. D17 STOP, DROP, AND DIE: PROTEOSTASIS AND AUTOPHAGY IN THE LUNG: Autophagy Deficiency Blocks Il-13 Muc5ac Mediated Secretion In Airway Epithelial …
  853. C60 QUALITY CONTROL IN LUNG CELLS: AUTOPHAGY AND PROTEOSTASIS: Decreased Phagocytosis Is Associated With Impaired Lc3 Expression In Nicotine …
  854. C60 QUALITY CONTROL IN LUNG CELLS: AUTOPHAGY AND PROTEOSTASIS: The Role Of Autophagy In Murine Adipose-Derived Mesenchymal Stromal Cell …
  855. … : A non-BRICHOS SFTPC mutant (SP-CI73T) linked to interstitial lung disease promotes a late block in macroautophagy disrupting cellular proteostasis and …
  856. D17 STOP, DROP, AND DIE: PROTEOSTASIS AND AUTOPHAGY IN THE LUNG: Crosstalk Between Efferocytosis And Autophagy In Alveolar Macrophages During …
  857. Modulation of neuronal mitochondrial dynamics, autophagy and huntingtin proteostasis by HDAC inhibitors: Insights for Huntington’s Disease
  858. C60 QUALITY CONTROL IN LUNG CELLS: AUTOPHAGY AND PROTEOSTASIS: Rapamycin Protects Ova Induced Asthma In Mice Through Regulating Autophagy
  859. MP22-08 PROTEOSTASIS BY HSP70/STUB1 COMPLEX REGULATES ANDROGEN RECEPTOR VARIANTS EXPRESSION AND CONFERS RESISTANCE TO …
  860. C60 QUALITY CONTROL IN LUNG CELLS: AUTOPHAGY AND PROTEOSTASIS: Autophagy And The Unfolded Protein Response Are Necessary For Tgf [Beta] 1 …
  861. C60 QUALITY CONTROL IN LUNG CELLS: AUTOPHAGY AND PROTEOSTASIS: Enhanced Autophagy Of Pulmonary Endothelial Cells On Exposure To Hiv-Protein …
  862. 849 The Nucleolus as a Proteostasis Regulator Fatima Amer-Sarsour and Avraham Ashkenazi 851 Apoptotic Caspases: A Double-Edged Sword in Radiation-Induced …
  863. D17 STOP, DROP, AND DIE: PROTEOSTASIS AND AUTOPHAGY IN THE LUNG: The Surfactant Protein C I73t Missense Mutation Induces A Cellular Phenotype …
  864. C60 QUALITY CONTROL IN LUNG CELLS: AUTOPHAGY AND PROTEOSTASIS: Cytosolic Alpha-1 Proteinase Inhibitor Regulates Mitochondrial Superoxide …
  865. Cytoplasmic Aggregates Of Human Tdp-25 Protein In C. Elegans Challenge Proteostasis
  866. Abstract A2-57: Identification of genetic vulnerabilities within the proteostasis network of multiple myeloma
  867. C108 AGING: THE COMMON DENOMINATOR: Hic-5/nox4 Signaling Regulates Proteostasis And Senescence
  868. A Highlights from MBoC Selection: Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine …
  869. The role of PQM-1 in proteostasis and transcellular chaperone signalling
  870. Dynamin-Related Protein 1 Regulates Proteostasis and Proprotein Convertase Subtilisin/Kexin Type 9 Secretion
  871. IL‐6 modulates cardiac muscle proteostasis and anti‐oxidative capacity post‐burn
  872. Inhibition of Histone Deacetylase-6 (HDAC6) Protects Against Atrial Remodeling Through Derailment of a-Tubulin Proteostasis in Experimental and Human Atrial …
  873. Activation of Histone Deacetylase-6 (HDAC6) Induces Contractile Dysfunction Through Derailment of α-Tubulin Proteostasis in Experimental and Human Atrial …
  874. Activation of Histone Deacetylase-6 (HDAC6) Induces Contractile Dysfunction through Derailment of α-Tubulin Proteostasis in Experimental and Human Atrial …
  875. Session 9: Proteostasis and stress response
  876. Adapting proteostasis for disease intervention
  877. Functional modules of the proteostasis network
  878. Chemical biology framework to illuminate proteostasis
  879. Mitochondria-associated proteostasis
  880. Proteostasis failure in neurodegenerative diseases: Focus on oxidative stress
  881. When endoplasmic reticulum proteostasis meets the DNA damage response
  882. Adapting the proteostasis capacity to sustain brain healthspan
  883. Inflammasomes and proteostasis novel molecular mechanisms associated with atrial fibrillation
  884. The intrinsic proteostasis network of stem cells
  885. Proteostasis Disturbances and Inflammation in Neurodegenerative Diseases
  886. Proteostasis of islet amyloid polypeptide: a molecular perspective of risk factors and protective strategies for type II diabetes
  887. Cellular proteostasis decline in human senescence
  888. Mechanisms linking mitochondrial dysfunction and proteostasis failure
  889. Extracellular proteostasis prevents aggregation during pathogenic attack
  890. Cell-nonautonomous regulation of proteostasis in aging and disease
  891. The protein disulfide isomerase family: from proteostasis to pathogenesis
  892. Proteasome inhibitors: Harnessing proteostasis to combat disease
  893. QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis
  894. PARPs and ADP-ribosylation in RNA biology: from RNA expression and processing to protein translation and proteostasis
  895. Interplay between mitochondrial oxidative disorders and proteostasis in Alzheimer’s disease
  896. Zinc at the crossroads of exercise and proteostasis
  897. Mitochondrial quality control and cellular proteostasis: two sides of the same coin
  898. Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming
  899. Mitochondria in Alzheimer’s disease and their potential role in Alzheimer’s proteostasis
  900. Mastering organismal aging through the endoplasmic reticulum proteostasis network
  901. Maternal immune activation in mice disrupts proteostasis in the fetal brain
  902. Build-UPS and break-downs: metabolism impacts on proteostasis and aging
  903. Cancer and pH dynamics: Transcriptional regulation, proteostasis, and the need for new molecular tools
  904. Embryo integrity regulates maternal proteostasis and stress resilience
  905. Proteostasis of α-Synuclein and Its Role in the Pathogenesis of Parkinson’s Disease
  906. Thyroglobulin interactome profiling defines altered proteostasis topology associated with thyroid dyshormonogenesis
  907. Disruption of cellular proteostasis by H1N1 influenza A virus causes α-synuclein aggregation
  908. Hematopoietic stem cell regulation by the proteostasis network
  909. FOXO1 deficiency impairs proteostasis in aged T cells
  910. Integrating ER and mitochondrial proteostasis in the healthy and diseased heart
  911. The dual roles of clusterin in extracellular and intracellular proteostasis
  912. Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity
  913. Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress
  914. Molecular perspectives of mitochondrial adaptations and their role in cardiac proteostasis
  915. BAG3 proteomic signature under proteostasis stress
  916. Proteostasis failure and cellular senescence in long‐term cultured postmitotic rat neurons
  917. Pharmacologic approaches for adapting proteostasis in the secretory pathway to ameliorate protein conformational diseases
  918. Noise exposures causing hearing loss generate proteotoxic stress and activate the proteostasis network
  919. The yeast FIT2 homologs are necessary to maintain cellular proteostasis and membrane lipid homeostasis
  920. Mitochondrial proteostasis requires genes encoded in a neurodevelopmental syndrome locus
  921. … and meta-analysis of human transcriptomics reveals neuroinflammation, deficient energy metabolism, and proteostasis failure across neurodegeneration
  922. Vimentin’s side gig: Regulating cellular proteostasis in mammalian systems
  923. Does proteostasis get lost in translation? Implications for protein aggregation across the lifespan
  924. Proteostasis unbalance of nucleophosmin 1 in Acute Myeloid Leukemia: An aggregomic perspective
  925. Hedgehog signaling modulates glial proteostasis and lifespan
  926. From beta amyloid to altered proteostasis in Alzheimer’s disease
  927. LONP1 and ClpP cooperatively regulate mitochondrial proteostasis for cancer cell survival
  928. The eIF2α kinase HRI in innate immunity, proteostasis, and mitochondrial stress
  929. Challenging proteostasis: role of the chaperone network to control aggregation-prone proteins in human disease
  930. Chaperones and proteostasis: Role in Parkinson’s Disease
  931. Plant proteostasis-shaping the proteome: a research community aiming to understand molecular mechanisms that control protein abundance
  932. A Mitochondrial Stress-Specific Form of HSF1 Protects against Age-Related Proteostasis Collapse
  933. Mitochondrial cross-compartmental signalling to maintain proteostasis and longevity
  934. Therapeutic role of a cysteine precursor, OTC, in ischemic stroke is mediated by improved proteostasis in mice
  935. Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes
  936. How autophagy can restore proteostasis defects in multiple diseases?
  937. VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism
  938. Corrupted ER‐mitochondrial calcium homeostasis promotes the collapse of proteostasis
  939. Proteostasis in the Male and Female Germline: A New Outlook on the Maintenance of Reproductive Health
  940. The selective autophagy receptor SQSTM1/p62 improves lifespan and proteostasis in an evolutionarily conserved manner
  941. Redefining proteostasis transcription factors in organismal stress responses, development, metabolism, and health
  942. Maintaining proteostasis under mechanical stress
  943. Mitochondrial DNA variants modulate N-formylmethionine, proteostasis and risk of late-onset human diseases
  944. Proteomic analysis links alterations of bioenergetics, mitochondria-ER interactions and proteostasis in hippocampal astrocytes from 3xTg-AD mice
  945. Proteostasis in viral infection: Unfolding the complex virus–chaperone interplay
  946. The interplay between redox signalling and proteostasis in neurodegeneration: In vivo effects of a mitochondria-targeted antioxidant in Huntington’s disease …
  947. Targeting the mitochondria-proteostasis axis to delay aging
  948. Acute intermittent porphyria: an overview of therapy developments and future perspectives focusing on stabilisation of HMBS and proteostasis regulators
  949. Defective gating and proteostasis of human clC-1 chloride channel: molecular pathophysiology of myotonia congenita
  950. Fluc‐EGFP reporter mice reveal differential alterations of neuronal proteostasis in aging and disease
  951. Proteostasis disturbances and endoplasmic reticulum stress contribute to polycystic liver disease: new therapeutic targets
  952. Small-molecule endoplasmic reticulum proteostasis regulator acts as a broad-spectrum inhibitor of dengue and Zika virus infections
  953. A genetic screen identifies new steps in oocyte maturation that enhance proteostasis in the immortal germ lineage
  954. Proteostasis regulators modulate proteasomal activity and gene expression to attenuate multiple phenotypes in Fabry disease
  955. Raloxifene is a female-specific proteostasis therapeutic in the spinal cord
  956. Targeting cellular senescence based on interorganelle communication, multilevel proteostasis, and metabolic control
  957. Insights into the molecular basis of genome stability and pristine proteostasis in naked mole-rats
  958. Changes in Metabolism and Proteostasis Drive Aging Phenotype in Aplysia californica Sensory Neurons
  959. Starting at the beginning: endoplasmic reticulum proteostasis and systemic amyloid disease
  960. Altered proteostasis in neurodegenerative tauopathies
  961. Amyotrophic Lateral Sclerosis: Proteins, Proteostasis, Prions, and Promises
  962. The role of proteostasis in the regulation of cardiac intercellular communication
  963. Nuclear ubiquitin-proteasome pathways in proteostasis maintenance
  964. Proteostasis in thermogenesis and obesity
  965. The molecular chaperone CCT/TRiC: An essential component of proteostasis and a potential modulator of protein aggregation
  966. Implications of long non-coding RNAs in age-altered proteostasis
  967. Increased supraorganization of respiratory complexes is a dynamic multistep remodelling in response to proteostasis stress
  968. Nicotinamide riboside enhances mitochondrial proteostasis and adult neurogenesis through activation of mitochondrial unfolded protein response signaling …
  969. The Zscan4-Tet2 transcription nexus regulates metabolic rewiring and enhances proteostasis to promote reprogramming
  970. Membrane dynamics and protein targets of lipid droplet microautophagy during ER stress-induced proteostasis in the budding yeast, Saccharomyces cerevisiae
  971. Differential effects of rapamycin and metformin in combination with rapamycin on mechanisms of proteostasis in cultured skeletal myotubes
  972. … : Shared and divergent properties of wild type and mutant UBQLN2 in phase separation, subcellular localization, altered proteostasis pathways, and selective …
  973. USP11 controls R-loops by regulating senataxin proteostasis
  974. Systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma of C. elegans
  975. Basic limonoid modulates chaperone-mediated proteostasis and dissolve Tau fibrils
  976. Multiple myeloma cells are exceptionally sensitive to heat shock, which overwhelms their proteostasis network and induces apoptosis
  977. Pharmacologic targeting of plasma cell endoplasmic reticulum proteostasis to reduce amyloidogenic light chain secretion
  978. Protein synthesis in the developing neocortex at near-atomic resolution reveals Ebp1-mediated neuronal proteostasis at the 60S tunnel exit
  979. Proteostasis regulators as potential rescuers of PMM2 activity
  980. Stimulation of cytoprotective autophagy and components of mitochondrial biogenesis/proteostasis in response to ionizing radiation as a credible pro-survival strategy
  981. Distinct modes of balancing glomerular cell proteostasis in mucolipidosis type II and III prevent proteinuria
  982. PolyQ-expanded proteins impair cellular proteostasis of ataxin-3 through sequestering the co-chaperone HSJ1 into aggregates
  983. Resetting proteostasis with ISRIB promotes epithelial differentiation to attenuate pulmonary fibrosis
  984. Biological evaluation and in silico study of benzoic acid derivatives from Bjerkandera adusta targeting proteostasis network modules
  985. Designing novel therapies to mend broken hearts: ATF6 and cardiac proteostasis
  986. Dietary protein, exercise, ageing and physical inactivity: Interactive influences on skeletal muscle proteostasis
  987. Acute Neural and Proteostasis Messenger Ribonucleic Acid Levels Predict Chronic Locomotor Recovery after Contusive Spinal Cord Injury
  988. The NADH dehydrogenase Nde1 executes cell death after integrating signals from metabolism and proteostasis on the mitochondrial surface
  989. Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance
  990. Intramitochondrial proteostasis is directly coupled to α-synuclein and amyloid β1-42 pathologies
  991. The proteostasis guardian HSF1 directs the transcription of its paralog and interactor HSF2 during proteasome dysfunction
  992. Multiomics-identified intervention to restore ethanol-induced dysregulated proteostasis and secondary sarcopenia in alcoholic liver disease
  993. Proteostasis is adaptive: Balancing chaperone holdases against foldases
  994. Elucidation of proteostasis defects caused by osteogenesis imperfecta mutations in the collagen-α2 (I) C-propeptide domain
  995. A novel stable isotope approach demonstrates surprising degree of age-related decline in skeletal muscle collagen proteostasis
  996. Insulin-induced de novo lipid synthesis occurs mainly via mTOR-dependent regulation of proteostasis of SREBP-1c
  997. Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging
  998. The aging proteostasis decline: From nematode to human
  999. Attenuation of ischemic stroke-caused brain injury by a monoamine oxidase inhibitor involves improved proteostasis and reduced neuroinflammation
  1000. Genome-wide signatures of plastid-nuclear coevolution point to repeated perturbations of plastid proteostasis systems across angiosperms
  1001. Secretory proteostasis of the retinal pigmented epithelium: Impairment links to age-related macular degeneration
  1002. Knock-in of mutated hTAU causes insulin resistance, inflammation and proteostasis disturbance in a mouse model of frontotemporal dementia
  1003. Mitochondria-affecting small molecules ameliorate proteostasis defects associated with neurodegenerative diseases
  1004. A perspective on the potential involvement of impaired proteostasis in neuropsychiatric disorders
  1005. The Role of Proteostasis Derailment in Cardiac Diseases
  1006. Extracellular Proteostasis: Laying Siege to Pathogens
  1007. Revealing functional insights into ER proteostasis through proteomics and interactomics
  1008. Does inter-organellar proteostasis impact yeast quality and performance during beer fermentation?
  1009. Author Correction: Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity
  1010. Phenotypic Discovery of Neuroprotective Agents by Regulation of Tau Proteostasis via Stress‐Responsive Activation of PERK Signaling
  1011. Regular Exercise Participation Contributes to Better Proteostasis, Inflammatory Profile, and Vasoactive Profile in Patients With Hypertension
  1012. Transcriptomic and proteostasis networks of CFTR and the development of small molecule modulators for the treatment of cystic fibrosis lung disease
  1013. The Cryo-EM Effect: Structural Biology of Neurodegenerative Disease Proteostasis Factors
  1014. Lanosterol modulates proteostasis via dissolving cytosolic sequestosomes/aggresome-like induced structures
  1015. Role of IRE1α in podocyte proteostasis and mitochondrial health
  1016. Double hit viral parasitism, polymicrobial CNS residency and perturbed proteostasis in Alzheimer’s disease: a data driven, in silico analysis of gene expression data
  1017. Loss of Fis1 impairs proteostasis during skeletal muscle aging in Drosophila
  1018. Exercise alters the mitochondrial proteostasis and induces the mitonuclear imbalance and UPR mt in the hypothalamus of mice
  1019. Endogenous siRNAs promote proteostasis and longevity in germline-less Caenorhabditis elegans
  1020. ATF6 as a Nodal Regulator of Proteostasis in the Heart
  1021. Beyond Proteostasis: Lipid Metabolism as a New Player in ER Homeostasis
  1022. Expression of mutant ubiquitin and proteostasis impairment in Kii Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex brains
  1023. Proteostasis network alteration in lysosomal storage disorders: Insights from the mouse model of Krabbe disease
  1024. Therapeutic targeting of proteostasis in Amyotrophic Lateral Sclerosis—a systematic review and meta-analysis of preclinical research
  1025. Chaperone-mediated autophagy: a gatekeeper of neuronal proteostasis
  1026. Therapeutic Approaches Targeting Proteostasis in Kidney Disease and Fibrosis
  1027. Inflammation, Extracellular Matrix Remodeling, and Proteostasis in Tumor Microenvironment
  1028. The sigma-1 receptor at the crossroad of proteostasis, neurodegeneration, and autophagy
  1029. The transfer of specific mitochondrial lipids and proteins to lipid droplets contributes to proteostasis upon stress and aging in the eukaryotic model system …
  1030. Protein trapping leads to altered synaptic proteostasis in synucleinopathies
  1031. Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4
  1032. MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration
  1033. The functions and regulation of heat shock proteins; key orchestrators of proteostasis and the heat shock response
  1034. Proteostasis Regulators Restore Function of Epilepsy-Associated GABAA Receptors
  1035. Determining the effects of nanoparticulate air pollution on proteostasis in Caenorhabditis elegans
  1036. Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers
  1037. Colonization of the Caenorhabditis elegans gut with human enteric bacterial pathogens leads to proteostasis disruption that is rescued by butyrate
  1038. The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function
  1039. CUL4-DDB1-CRBN E3 ubiquitin ligase regulates proteostasis of ClC-2 chloride channels: implication for aldosteronism and leukodystrophy
  1040. Protein S-nitrosylation regulates proteostasis and viability of hematopoietic stem cell during regeneration
  1041. Homeostatic Roles of the Proteostasis Network in Dendrites
  1042. Pinpointing oxidative stress behind the white striping myopathy: Depletion of antioxidant defenses, accretion of oxidized proteins and impaired proteostasis
  1043. Cleaning the molecular machinery of cells via proteostasis, proteolysis and endocytosis selectively, effectively, and precisely: intracellular self-defense and cellular …
  1044. Divergent modulation of proteostasis in prostate cancer
  1045. Effects of Cell Proteostasis Network on the Survival of SARS-CoV-2
  1046. Proteostasis and proteotoxicity in the network medicine era
  1047. The Proteome Folding Problem and Cellular Proteostasis
  1048. Stochastic and Age‐Dependent Proteostasis Decline Underlies Heterogeneity in Heat‐Shock Response Dynamics
  1049. Alpha 1-antitrypsin deficiency: a disorder of proteostasis-mediated protein folding and trafficking pathways
  1050. Proteome-scale mapping of perturbed proteostasis in living cells
  1051. Protective effects of cannabidiol on the membrane proteins of skin keratinocytes exposed to hydrogen peroxide via participation in the proteostasis network
  1052. CSNAP, the smallest CSN subunit, modulates proteostasis through cullin-RING ubiquitin ligases
  1053. Proteostasis Regulation in the Endoplasmic Reticulum: An Emerging Theme in the Molecular Pathology and Therapeutic Management of Familial …
  1054. Acceleration of ageing via disturbing mTOR‐regulated proteostasis by a new ageing‐associated gene PC4
  1055. Proteostasis dysfunction in aged mammalian cells. The stressful role of inflammation
  1056. Inhibition of the oligosaccharyl transferase in Caenorhabditis elegans that compromises ER proteostasis suppresses p38-dependent protection against …
  1057. Expression of Amyloidogenic Transthyretin Drives Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease
  1058. The Traditional Formula Kai-Xin-San Alleviates Polyglutamine-Mediated Neurotoxicity by Modulating Proteostasis Network in Caenorhabditis elegans
  1059. Mapping sites of carboxymethyllysine modification on proteins reveals its consequences for proteostasis and cell proliferation
  1060. Cellular proteostasis decline in human senescence
  1061. Mitochondrial proteostasis requires genes encoded in a neurodevelopmental syndrome locus that are necessary for synapse function
  1062. SUMOylation contributes to proteostasis of the chloroplast protein import receptor TOC159 during early development
  1063. Understanding and exploiting interactions between cellular proteostasis pathways and infectious prion proteins for therapeutic benefit
  1064. The impact of proteostasis dysfunction secondary to environmental and genetic causes on neurodegenerative diseases progression and potential therapeutic …
  1065. Harnessing the Proteostasis Network in Alcohol-associated Liver Disease
  1066. Functional genomics screen identifies proteostasis targets that modulate prion protein (PrP) stability
  1067. The interplay between proteostasis systems and Parkinson’s disease
  1068. Aggresomes predict poor outcomes and implicate proteostasis in the pathogenesis of pediatric choroid plexus tumors
  1069. Deciphering the Proteotoxic Stress Responses Triggered by the Perturbed Thylakoid Proteostasis in Arabidopsis
  1070. Lysosomes to the rescue: Anterograde axonal lysosome transport and neuronal proteostasis
  1071. The switch-like expression of heme-regulated kinase 1 mediates neuronal proteostasis following proteasome inhibition
  1072. Chrysanthemum zawadskil Herbich attenuates dexamethasone-induced muscle atrophy through the regulation of proteostasis and mitochondrial function
  1073. In case of stress, hold tight: phosphorylation switches PDI from an oxidoreductase to a holdase, tuning ER proteostasis
  1074. Regulation of the proteostasis network during enterovirus infection: A feedforward mechanism for EV-A71 and EV-D68
  1075. The SINEB1 element in the long non-coding RNA Malat1 is necessary for TDP-43 proteostasis
  1076. Peroxiredoxin 6 mediates protective function of astrocytes in Aβ proteostasis
  1077. Altered transcriptome-proteome coupling indicates aberrant proteostasis in Parkinson’s disease
  1078. Proteostasis-associated aging: lessons from a Drosophila model
  1079. Addendum: a lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage
  1080. Translational control of gene expression by eIF2 modulates proteostasis and extends lifespan
  1081. Activation of the unfolded protein response and proteostasis disturbance in parkinsonism-dementia of Guam
  1082. The linear ubiquitin E3 ligase-Relish pathway is involved in the regulation of proteostasis in Drosophila muscle during aging
  1083. ATG9A regulates proteostasis through reticulophagy receptors FAM134B and SEC62 and folding chaperones CALR and HSPB1
  1084. … Potential of Yeast Cells Depends on Overall Action of Interconnected Changes in Central Carbon Metabolism, Cellular Biosynthetic Capacity, and Proteostasis
  1085. The Importance of Autophagy and Proteostasis in Metabolic Cardiomyopathy
  1086. Estimating the number of protein molecules in a plant cell: a quantitative perspective on proteostasis and amino acid homeostasis during progressive drought stress
  1087. … supplementation ameliorates hypobaric hypoxia‐induced skeletal muscle loss via attenuating endoplasmic reticulum stress response and maintaining proteostasis
  1088. Lysosomal nucleotide metabolism regulates ER proteostasis through mTOR signaling
  1089. Mucosal humoral immunity in cystic fibrosis-a tangled web of failed proteostasis, infection and adaptive immunity
  1090. Proteostasis Dysfunction in Aged Mammalian Cells. The Stressful Role of Inflammation
  1091. … selenium on modulation of expression of several non-selenoprotein genes related to key ovarian functions, female fertility, and proteostasis: a transcriptome-based …
  1092. Functional connections between cell cycle and proteostasis in the regulation of Candida albicans morphogenesis
  1093. Distinct metabolic states of a cell guide alternate fates of mutational buffering through altered proteostasis
  1094. DNA Methyltransferase 1 (DNMT1) Acts on neurodegeneration by modulating proteostasis-relevant intracellular processes
  1095. Tetraspanin1 promotes NGF signaling by controlling TrkA receptor proteostasis
  1096. Regulation of autophagy by VPS34 branched ubiquitination controls proteostasis and liver metabolism
  1097. Resetting proteostasis with ISRIB prevents pulmonary fibrosis
  1098. The architecture of protein synthesis in the developing neocortex at near-atomic resolution reveals Ebp1-mediated neuronal proteostasis at the 60S tunnel …
  1099. ER proteostasis regulators reduce amyloidogenic light chain secretion through an on-target, ATF6-independent mechanism
  1100. Kinetic Monitoring Of Neuronal Stress Response To Proteostasis Dysfunction
  1101. Protein intake and loss of Proteostasis in the eldery
  1102. Temporal requirements of SKN-1/NRF as a regulator of lifespan and proteostasis in Caenorhabditis elegans
  1103. … of endoplasmic reticulum (ER) Ca2+ stores by deletion of inositol‐1,4,5‐trisphosphate receptor type 1 promotes ER retrotranslocation, proteostasis, and protein outer …
  1104. ADEP1 activated ClpP1P2 macromolecule of Leptospira, an ideal Achilles’ heel to deregulate proteostasis and hamper the cell survival
  1105. High-content analysis of proteostasis capacity in cellular models of amyotrophic lateral sclerosis (ALS)
  1106. Disruption of Endoplasmic Reticulum Proteostasis in Age-Related Nervous System Disorders
  1107. Analysis of proteostasis during aging with western blot of detergent-soluble and insoluble protein fractions
  1108. The diverse functions of small heat shock proteins in the proteostasis network
  1109. Proteostasis Dysregulation in Pancreatic Cancer
  1110. Dengue and Zika virus infection are impaired by small molecule ER proteostasis regulator 147 in an ATF6-independent manner
  1111. A role for mitochondrial DNA in cellular proteostasis
  1112. Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma
  1113. How Isomerization and Epimerization in Long‐Lived Proteins Affect Lysosomal Degradation and Proteostasis
  1114. METTL18-mediated histidine methylation on RPL3 modulates translation elongation for proteostasis maintenance
  1115. DOPAL initiates αSynuclein-mediated impaired proteostasis in neuronal projections leading to enhanced vulnerability in Parkinson’s disease.
  1116. MicroRNA Regulation and Cellular Proteostasis in Parkinson’s Disease
  1117. Therapeutic potential of insulin-like growth factor 2 in Huntington’s disease: controlling proteostasis to alleviate the load of misfolded protein
  1118. Regulation of ClC-2 Chloride Channel Proteostasis by Molecular Chaperones: Correction of Leukodystrophy-Associated Defect
  1119. Distinct proteostasis states drive pharmacologic chaperone susceptibility for Cystic Fibrosis Transmembrane Conductance Regulator misfolding mutants
  1120. Lipid droplets modulate proteostasis, SQST-1/SQSTM1 dynamics, and lifespan in C. elegans
  1121. Metabolically Activated Proteostasis Regulators Protect Against Glutamate Toxicity by Activating NRF2
  1122. The JAK2-STAT3 pathway controls a beneficial proteostasis response of reactive astrocytes in Huntington disease
  1123. Impaired mRNA splicing and proteostasis in preadipocytes in obesity-related metabolic disease
  1124. Mathematical model of a short translatable G-quadruplex and an assessment of its relevance to misfolding-induced proteostasis
  1125. Nicotinamide riboside alleviates Parkinson’s disease symptoms but downregulates dopamine metabolism upon lactacystin-induced proteostasis failure
  1126. Beyond Proteostasis: Lipid Metabolism as a New Player in ER Homeostasis. Metabolites 2021, 11, 52
  1127. Characterization of Proteostasis Mechanisms in Chlamydia Trachomatis
  1128. Proteostasis and Viral Evolution
  1129. A virtuous cycle operated by ERp44 and ERGIC-53 guarantees proteostasis in the early secretory compartment
  1130. Proteostasis and Disease: From Basic Mechanisms to Clinics
  1131. Yeast FIT2 homolog is necessary to maintain cellular proteostasis by regulating lipid homeostasis
  1132. Proteostasis and Neurodegeneration: Perspectives in the Pathogenesis of Molecular and Cellular Mechanisms
  1133. XBP1s-Mediated Endoplasmic Reticulum Proteostasis Network Enhancement Can Selectively Improve Folding and Secretion of an Osteogenesis Imperfecta-Causing …
  1134. Novel proteostasis reporter mouse reveals different effects of cytoplasmic and nuclear aggregates on protein quality control in neurons
  1135. The Host Cell’s Endoplasmic Reticulum Proteostasis Network Profoundly Shapes the Protein Sequence Space Accessible to HIV Envelope
  1136. Compartment-specific proteostasis
  1137. Characterization of proteostasis loss in neurodegeneration using a proteomics approach
  1138. Linking proteostasis, aging, and brain ischemia
  1139. Ribosome protein mutant cells rely on the GR64 cluster of gustatory receptors for survival and proteostasis in Drosophila
  1140. Nuclear Ubiquitin-Proteasome Pathways in Proteostasis Maintenance. Biomolecules 2021, 11, 54
  1141. Autophagy and proteostasis adjustment role in normal brain function and neurodegenerative disorders
  1142. Untargeted 1H NMR Metabolomics and Pathway Analysis Reveals Dysregulated Proteostasis in Cyclophilin D (CypD)-deficient Mice Tissues
  1143. Phytochemical Nrf2 activator attenuates skeletal muscle mitochondrial dysfunction and impaired proteostasis in a preclinical model of musculoskeletal aging
  1144. A new mouse model to study neuronal proteostasis
  1145. Small Molecule ER Proteostasis Regulators Reduce Amyloidogenic Immunoglobulin Light Chain Secretion Through an On-Target, ATF6-Independent Mechanism
  1146. New intervention strategies in aging and cancer based on gene edition and proteostasis modulation
  1147. Proteostasis of Glial Intermediate Filaments: Disease Models, Tools, and Mechanisms
  1148. Divergent Modulation of Proteostasis in Prostate Cancer.
  1149. Selected Conference Abstracts from “The Regulation of Proteostasis in Cancer”
  1150. Modifying the proteostasis status: the role of cross-organelle communication
  1151. Regulation of proteostasis and proteasome function by cigarette smoke
  1152. Discovery of a molecular glue that enhances UPRmt to restore proteostasis via TRKA-GRB2-EVI1-CRLS1 axis
  1153. A genetic screen identifies processes that couple oocyte maturation to proteostasis in the immortal C. elegans germ lineage
  1154. Muscle physiology and proteostasis–Effects of changes in muscle size and exercise
  1155. Molecular Chaperones in Neurodegeneration: Mechanisms of Regulation in Cellular Proteostasis
  1156. Universal protein misfolding intermediates can bypass the proteostasis network and remain soluble and non-functional
  1157. A role of SUMOylation in proteostasis, centromere integrity and the DNA damage response
  1158. Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity
  1159. Adapting Proteostasis and Autophagy for Controlling the Pathogenesis of Cystic Fibrosis Lung
  1160. The interplay between arginine dimethylation and ubiquitylation coordinates TDP1 proteostasis for the repair of topoisomerase I covalent complexes
  1161. Prolonged disturbance of proteostasis induces cellular senescence via temporal mitochondrial dysfunction and enhanced mitochondrial biogenesis in human …
  1162. Mitochondrial DNA variants modulate proteostasis through N-formylmethionine
  1163. Microfluidics: Stochastic and Age‐Dependent Proteostasis Decline Underlies Heterogeneity in Heat‐Shock Response Dynamics (Small 30/2021)
  1164. Cleaning up translation failures: how Ribosome-associated Quality Control maintains cellular proteostasis
  1165. Divergent Modulation of Proteostasis in Prostate Cancer
  1166. … E. Coli Proteome it is Common for Proteins to Become Kinetically Trapped in Soluble, Near-Native, Non-Functional Conformations that Bypass the Proteostasis …
  1167. Erratum to “mTOR/AMPK signaling in the brain: Cell metabolism, proteostasis and survival”,[Curr Opin Toxicol, Volume 8, April 2018, Pages 102–110](Current Opinion …
  1168. Microglia implicated in tau proteostasis disturbances in the striatum of neurodegenerative disease patients from genotype to phenotype
  1169. Acute neural and proteostasis mRNA levels predict chronic locomotor recovery after contusive spinal cord injury.
  1170. Cellular proteostasis decline in human senescence
  1171. Mechanisms of statin effects on muscle and neuronal proteostasis
  1172. Quantitative and Multiplexed Chemical-Genetic Phenotyping Reveals the Architecture of the Proteostasis Network in Breast Cancer
  1173. The Role of Eicosanoids in Regulating the Ubiquitin Proteasome System and Proteostasis
  1174. GENETICALLY-DETERMINED MYB INSUFFICIENCY DIRECTLY IMPACTS ON PROTEOSTASIS IN HEMATOPOIETIC STEM CELLS PREDISPOSING TO AGE …
  1175. Abstract A54: Targeting new links in the proteostasis network as novel therapies in high-grade serous ovarian cancer
  1176. Increased supra-organization is a dynamic multistep remodelling of respiratory complexes against proteostasis stress
  1177. Mapping networks of alpha-Synuclein proteostasis in cellular models of Parkinson’s disease pathology
  1178. Erratum: Differential Effects of Rapamycin and Metformin in Combination with Rapamycin on Mechanisms of Proteostasis in Cultured Skeletal Myotubes (Journals of …
  1179. Endogenous siRNAs promote proteostasis and longevity in germline
  1180. Mitochondrial metabolism regulates cellular proteostasis
  1181. Visual dysfunction in a zebrafish FASD model is associated with retinal proteostasis impairment
  1182. Mutation‐Dependent Capacity of the ER Proteostasis Network to Quality Control Disease‐Causing Collagen Misfolding
  1183. TID1 Maintains Mitochondrial Proteostasis and Reduces Aging Effects in Stem Cells to Enhance Their Potential Against Doxorubicin Induced Cardiac Damage
  1184. Proteostasis Modulation Prevents Photoreceptor Pathology in Retinal Organoids
  1185. Prolonged disturbance of proteostasis induces cellular senescence via temporal mitochondrial
  1186. Squalene Monooxygenase at the Nexus between Cholesterol Homeostasis and Proteostasis
  1187. Modeling of Disease-Related SFTPC Mutations Links a Challenged Lung Epithelial Proteostasis Network and Pulmonary Fibrosis
  1188. Small Molecule Proteostasis Regulator Corrects Cone Photoreceptor Pathology in Retinal Organoids
  1189. Neonatal Maternal Separation Modifies Proteostasis Marker Expression in the Adult Hippocampus
  1190. Drug repurposing identifies inhibitors of the proteostasis network to augment radioiodine uptake in combinatorial approaches targeting thyroid cancer
  1191. Folding Mitochondrial-Mediated Cytosolic Proteostasis Into the Mitochondrial Unfolded Protein Response
  1192. Proteostasis failure and mitochondrial dysfunction leads to aneuploidy-induced senescence
  1193. … (ER) Ca2+ efflux channel inositol-1, 4, 5-trisphosphate receptor type 1 or ryanodine receptor 2 promotes ER retrotranslocation/proteostasis in cyclic nucleotide-gated …
  1194. Does TDP-43 Impact Neuronal Proteostasis?
  1195. Targeting of misfolded, pathogenic TDP‐43 with rationally designed antibodies: Nonhuman/Target identification and validation studies: Proteostasis
  1196. R&D Area for the Research and Development Objective “Understanding and medical application of proteostasis”(AMED-CREST, PRIME) Evaluation Panel Members
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