Polyamines & Their Effect On Brain (Nmda, Depression, Suicide Risk)

The relationship between polyamines, NMDA, and depression in suicide completers.

– **Polyamines and Depression in Suicide Completers:**Spermidine has been associated with suicide completers. Studies examining gene expression in the brains of mood-disordered suicide completers revealed altered expression of several polyamine-related genes, including spermidine/spermine N1-acetyltransferase, spermine oxidase, and spermine synthase¹. These findings highlight the dysregulation of the polyamine system in suicide and its importance in the neurobiology of this complex phenomenon.

– **NMDA and Depression in Suicide Completers:** – It is known that NMDA receptors play a crucial role in depression and suicide.

1. brain polyamine levels are altered in Alzheimer’s disease
2. polyamine transport, accumulation, and release in brain
3. The polyamine transporter Slc18b1(VPAT) is important for both short and long time memory and for regulation of polyamine content in the brain
4. polyamine catabolism is enhanced after traumatic brain injury
5. polyamine metabolism in different pathological states of the brain
6. Overview of the brain polyamine –stress-response: regulation, development, and modulation by lithium and role in cell survival
7. polyamine metabolism and function in brain
8. polyamine modification increases the permeability of proteins at the blood‐nerve and blood‐brain barriers
9. Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and …
10. Modification of biodistribution and brain uptake of copper bis (thiosemicarbazonato) complexes by the incorporation of amine and polyamine functional groups
11. The antistress effect of ginseng total saponin and ginsenoside Rg3 and Rb1 evaluated by brain polyamine level under immobilization stress
12. Pharmacological characterisation and autoradiographic distribution of polyamine -sensitive [3H] ifenprodil binding sites in the rat brain
13. Attenuation of brain Edema, Blood-brain Barrier Breakdown, and injury Volume by Ifenprodil, a polyamine -Site N-Methyl-d-aspartate Receptor Antagonist, after …
14. Contribution of polyamine oxidase to brain injury after trauma
15. polyamine reutilization and turnover in brain
16. polyamine metabolism in brain tumours: diagnostic relevance of quantitative biochemistry
17. Metabolomic studies identify changes in transmethylation and polyamine metabolism in a brain -specific mouse model of tuberous sclerosis complex
18. polyamine uptake, binding and release in rat brain
19. Arginase and arginine decarboxylase–where do the putative gate keepers of polyamine synthesis reside in rat brain ?
20. polyamine metabolism in transient focal ischemia of rat brain
21. Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle …
22. Changes in polyamine levels in rat brain after systemic kainic acid administration: relationship to convulsant activity and brain damage
23. Developmental regulation of the brain polyamine –stress-response
24. In Situ Metabolomics of the Honeybee brain : The Metabolism of l-Arginine through the polyamine Pathway in the Proboscis Extension Response (PER)
25. Maternal behavior as a regulator of polyamine biosynthesis in brain and heart of the developing rat pup
26. Ornithine decarboxylase, the rate-limiting enzyme of polyamine synthesis, modifies brain pathology in a mouse model of tuberous sclerosis complex
27. Depletion of 9L rat brain tumor cell polyamine content by treatment with D, L-α-difluoromethylornithine inhibits proliferation and the G1 to S transition
28. Effect of polyamine depletion on chromatin structure in U-87 MG human brain tumour cells
29. Regional brain polyamine levels in permanent focal cerebral ischemia
30. … of superoxide dismutase at the blood‐nerve and blood‐brain barriers with retained enzymatic activity after covalent modification with the naturally occurring polyamine …
31. Acute hypoxia increases ornithine decarboxylase activity and polyamine concentrations in fetal rat brain .
32. polyamine synthesis in mammalian tissues. Isolation and characterization of spermidine synthase from bovine brain
33. brain polyamine stress response: recurrence after repetitive stressor and inhibition by lithium
34. Evidence that the Kennedy and polyamine pathways are dysregulated in human brain in cases of dementia with Lewy bodies
35. polyamine synthesis in mammalian tissues: isolation and characterization of spermine synthase from bovine brain
36. polyamine metabolism in a rat brain tumor cell line: its relationship to the growth rate
37. polyamine biosynthesis in human fetal liver and brain
38. Blood–brain Barrier Breakdown in Cold‐Injured brain Is Linked to a Biphasic Stimulation of Ornithine Decarboxylase Activity and polyamine Synthesis: Both Are …
39. Autoradiographic Distribution and Characteristics of High‐ and Low‐Affinity polyamine ‐Sensitive [3H]Ifenprodil Sites in the Rat brain : Possible Relationship to …
40. Changes in brain polyamine levels following head injury
41. Radiation brain injury is reduced by the polyamine inhibitor α-difluoromethylornithine
42. Effect of maternal deprivation on polyamine metabolism in preweanling rat brain and heart
43. Developmental aspects of polyamine interconversion in rat brain
44. Effect of ifenprodil, a polyamine site NMDA receptor antagonist, on brain edema formation following asphyxial cardiac arrest in rats
45. Fungal Enzyme l-Lysine α-Oxidase Affects the Amino Acid Metabolism in the brain and Decreases the polyamine Level
46. polyamine Concentrations in the brain of Vitamin B12-Deficient Rats
47. Blood-brain barrier breakdown by cold injury. polyamine signals mediate acute stimulation of endocytosis, vesicular transport, and microvillus formation in rat cerebral …
48. Increases in brain polyamine concentrations in chemical kindling and single convulsion induced by pentylenetetrazol in rats
49. polyamine and aminoguanidine treatments to promote structural and functional recovery in the adult mammalian brain after injury: a brief literature review and …
50. Interrelations between polyamines and nucleic acids: changes of polyamine and nucleic acid concentrations in the developing rat brain
51. Interaction of a polyamine analogue, 1, 19-bis-(ethylamino)-5, 10, 15-triazanonadecane (BE-4-4-4-4), with DNA and effect on growth, survival, and polyamine levels in …
52. polyamine TURNOVER IN DIFFERENT REGIONS OF RAT brain 1
53. Increased polyamine concentrations in the cerebrospinal fluid of patients with brain tumors
54. Inhibitory role of ecdysone on neurogenesis and polyamine metabolism in the adult cricket brain
55. Developmental changes in mouse brain polyamine metabolism
56. polyamine metabolism in experimental brain tumors of rat
57. polyamine metabolism in the brain and liver of the developing monkey
58. Effect of immobilization stress on brain polyamine levels in spontaneously hypertensive and Wistar-Kyoto rats
59. Cellular proliferation and infiltration following interstitial irradiation of normal dog brain is altered by an inhibitor of polyamine synthesis
60. Effects of dl-α-methylornithine on proliferation and polyamine content of 9L rat brain tumor cells
61. polyamine metabolism and glutamate receptor agonists‐mediated excitotoxicity in the rat brain
62. polyamine effects on the NMDA receptor in human brain
63. Kainate-induced seizure activity stimulates the polyamine interconversion pathway in rat brain
64. polyamine levels in brain and plasma after acute restraint or water-immersion restraint stress in mice
65. Regulatory interrelations between GABA and polyamines. I. brain GABA levels and polyamine metabolism
66. THE EFFECT OF dl‐ALLYLGLYCINE ON polyamine AND GABA METABOLISM IN MOUSE brain
67. Relationship between tissue polyamine levels and malignancy in primary brain tumors
68. Dynamic and regional aspects of polyamine metabolism in the brain of trout (Salmo irideus Gibb.)
69. Decreased cytotoxicity of aziridinylbenzoquinone caused by polyamine depletion in 9L rat brain tumor cells in vitro
70. Chemotherapeutic choice of ranimustine or nimustine on the basis of regional polyamine levels in rat brain .
71. Seizure activity-induced changes in polyamine metabolism and neuronal pathology during the postnatal period in rat brain
72. Interrelationships between polyamines and nucleic acids. Changes of polyamine and nucleic acid concentrations in the growing fish brain (Salmo irideus Gibb.)
73. Activity of ornithine decarboxylase (ODC) and polyamine levels as biochemical markers of malignancy in human brain tumors.
74. Depletion of intracellular polyamine content does not alter the survival of 9L rat brain tumour cells after X-irradiation
75. Two polyamine analogs (BE-4-4-4 and BE-4-4-4-4) directly affect growth, survival, and cell cycle progression in two human brain tumor cell lines
76. The ability of polyamine analogues to induce Z-DNA structure in synthetic polynucleotides in vitro inversely correlates with their effects on cytotoxicity of cis …
77. Neonatal polyamine depletion by α-difluoromethylornithine: effects on adenylyl cyclase cell signaling are separable from effects on brain region growth
78. Regional distribution of ornithine decarboxylase activity and polyamine levels in experimental cat brain tumors
79. Regional Heterogeneity of polyamine Effects on the N‐Methyl‐D‐Aspartate Receptor in Rat brain
80. Influence of polyamine depletion caused by α-difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, on alkylation-and …
81. Effects of anesthesia on polyamine metabolism and water content in the rat brain
82. The polyamine synthesis inhibitor α-difluoromethylornithine is neuroprotective against N-methyl-D-aspartate-induced brain damage in vivo
83. Effects of felbamate on brain polyamine changes following transient cerebral ischemia in the Mongolian gerbil
84. Effect of eliprodil, an NMDA receptor antagonist acting at the polyamine modulatory site, on local cerebral glucose use in the rat brain
85. The rationale for the localization of polyamine pathway enzymes in the brain
86. polyamine Regulation of Protein Phosphorylation in the brain of the Tobacco Hornworm, Manduca sexta
87. Effects of bilateral olfactory bulb ablations on the polyamine levels in rat brain
88. Lithium exerts a time-dependent and tissue-selective attenuation of the dexamethasone-induced polyamine response in rat brain and liver
89. Study of the Characterization of Partial Purified polyamine Oxidase from Sheep’s brain Tissue
90. Changes in mitochondrial structure and function in 9L rat brain tumor cells treated in vitro with α-difluoromethylornithine, a polyamine biosynthesis inhibitor
91. Modulation of A1 adenosine receptor function in rat brain by the polyamine , spermine
92. Evaluation of polyamine levels in cerebrospinal fluid of children with brain tumors
93. Effect of treatment with difluoromethylornithine on polyamine and spectrin breakdown levels in neonatal rat brain
94. Trophic control of the ornithine decarboxylase/polyamine system in neonatal rat brain regions: lesions caused by 6-hydroxydopamine produce effects selective for …
95. Decreased cell kill of vincristine and methotrexate against 9L rat brain tumor cells in vitro caused by α-difluoromethylornithine-induced polyamine depletion
96. Correction: Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and …
97. Effects of the polyamine analogs BE-3-7-3, 3-8-3, and BE-3-8-3 on human brain tumor cell growth and survival.
98. Pentylenetetrazol-induced kindling stimulates the polyamine interconversion pathway in rat brain
99. Effect of kainate-induced seizure activity on the polyamine interconversion pathway in juvenile rat brain
100. Alterations in methylation affect polyamine biosynthesis in mouse brain
101. Reversal by polyamine of the aluminum-induced inhibition of hexokinase from human brain
102. Chemotherapeutic targeting of etoposide to regions of the brain on the basis of polyamine level
103. polyamine ‐enhanced NMDA ‐induced behavioural changes and FOS‐immunoreactivity in rat brain
104. Effects of fructose-1, 6-bisphosphate on brain polyamine biosynthesis in a model of transient cerebral ischemia
105. Erratum: Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and …
106. Thyroxine effects on polyamine metabolism in rat cerebellum and brain cortex during postnatal development.
107. Plasma polyamine changes and possible effects on hypofunctional NMDA receptor found in schlzophrenic brain
108. NMDA receptors mediate activation of polyamine synthesis and blood-brain barrier breakdown after cold injury
109. polyamine acetylation in the developing and aging mouse brain
110. Effect of lithium on the polyamine Response in brain after stress
111. Interaction of rigid polyamine analogues with the NMDA receptor complex from rat brain
112. Fos‐B expression is required for polyamine ‐induced increase in nuclear activator protein‐1 DNA binding in discrete structures of murine brain
113. Enhanced Uptake of [3 H] Spermidine by 9L Rat brain Tumors After Direct Intratumoral Infusion of Inhibitors of Enzymes of the polyamine Biosynthetic Pathway
114. … dependence of the potentiation of 1, 3-bis (2-chloroethyl)-1-nitrosourea cytotoxicity caused by α-difluoromethylornithine-induced polyamine depletion in 9L rat brain …
115. Effect of long-term space flight on polyamine levels in the rat brain
116. Reversible changes in goldfish brain polyamine concentrations and synthetic enzymes after cold exposure
117. polyamine contents in the brain and liver of rats during acclimatization to the cold
118. A New Target for Treatment of Schizophrenia: Agmatine and brain polyamine System
119. Ornithine decarboxylase activity and polyamine concentrations in fetal rat brain : response to chronic hypoxic-hypoxia and/or carbon monoxide-hypoxia
120. Possible involvement of humoral regulation in the effects of elevated cerebral 4‐aminobutyric acid levels on the polyamine metabolism in brain
121. Study of ocular tissue changes, brain GABA and polyamine levels in rats exposed to carbon disulfide.
122. Effect of melatonin administration on the immobilization stress-induced polyamine responses in brain and gastrointestinal tract
123. Pretreatment with the polyamine analog 1, 19-bis-(ethylamino)-5, 10, 15-triazanonadecane (BE-4-4-4-4) inhibits etoposide cytotoxicity in U-251 MG (NCI) human brain …
124. polyamine binding sites in the rat brain hippocampus plasma membranes: MK 801 does not influence the binding process
125. Spermine and L-NAME pretreatment effects on polyamine and nitric oxide metabolism in rat brain during seizures
126. Analysis of polyamine Level in Certain brain Regions of Aging Rats
127. Contribution of polyamine oxidase to brain injury after
128. … 2-carboxypiperazin-4-yl) propyl-1-phosphonic acid ([3H] CPP) binding by ligands acting at the glycine and the polyamine sites of the rat brain NMDA receptor complex
129. polyamine Uptake by Malignant brain Tumour Xenografts in Nude Mice
130. brain polyamine Metabolism During Soman-induced Status Epilepticus. Modulation with alpha-DFMO.
131. polyamine modulation of phosphorylation of channel-forming cytosolic protein in bovine brain
132. Pentylenetetrazol-induced kindling stimulates polyamine acetylation in rat brain
133. … for Treatment of Alzheimer Disease by polyamine Modification of Antioxidant Enzymes and Neurotrophic Factors to Increase Their Permeability at the Blood-brain …
134. polyamine acetylation in rat brain during N-ethyl-N-nitrosourea-induced cerebral carcinogenesis
135. Influences of Hydrocortisone, DHEA, Estradiol and Testosterone on the polyamine Metabolism of Mouse brain , Kidney, Liver and Intestine
136. Anti-stress effects of the ginsenosides Rg3 and R bl on the changes in brain polyamine levels after immobilization stress
137. Effect of Melatonin on brain polyamine Contents and Hippocampal Neuronal Damage after Transient Global Ischemia in Mongolian Gerbil
138. Choice of vincristine or 6-mercaptopurine on the basis of polyamine level in tumor-bearing regions of the brain
139. Modulation of the NMDA receptor by polyamines
140. Control of proton sensitivity of the NMDA receptor by RNA splicing and polyamines
141. Molecular basis of positive allosteric modulation of GluN2B NMDA receptors by polyamines
142. Characterization of polyamines having agonist, antagonist, and inverse agonist effects at the polyamine recognition site of the NMDA receptor
143. Role of polyamines and NMDA receptors in ethanol dependence and withdrawal
144. The involvement of the polyamines binding sites at the NMDA receptor in creatine-induced spatial learning enhancement
145. polyamines contribute to ethanol withdrawal‐induced neurotoxicity in rat hippocampal slice cultures through interactions with the NMDA receptor
146. Effects of polyamines on NMDA -induced currents in rat hippocampal neurons: a whole-cell and single-channel study
147. polyamines modulate the neurotoxic effects of NMDA in vivo
148. The role of hydrophobic interactions in binding of polyamines to non NMDA receptor ion channels
149. glutamate and glycine co-activate while polyamines merely modulate the NMDA receptor complex.
150. The polyamines, spermine and spermidine, negatively modulate N-methyl-d-aspartate (NMDA ) and quisqualate receptor mediated responses in vivo: Cerebellar …
151. polyamines and the NMDA receptor: Modifying intrinsic activities with aromatic substituents
152. Lack of evidence for direct involvement of NMDA receptors or polyamines in blood–brain barrier injury after cerebral ischemia in rats
153. polyamines and NMDA receptors modulate pericapillary astrocyte swelling following cerebral cryo-injury in the rat
154. Motor depressant effects of systemically administered polyamines in mice: involvement of central NMDA receptors
155. Histamine release from mast cells by polyamines: an NMDA receptor-mediated event?
156. polyamines modulate [3H] L-689 binding to the glycine site of the NMDA receptor from rat brain
157. polyamines modulate events mediated by the N-methyl-D-aspartate (NMDA ) receptor complex through an ifenprodil-insensitive pathway: in vivo measurements of …
158. Histamine and NMDA -receptors in the hippocampus: polyamines and intracellular binding site.
159. Differential effects of linear and cyclic polyamines on NMDA receptor activities
160. Comparison of anti-amnesia properties of NMDA -receptor” fast” blockers and polyamines
161. Do polyamines regulate the NMDA inhibition of muscarinic receptor-induced phosphoinositide turnover in guinea pig brain ?
162. Anatomical and developmental heterogeneity of the effects of polyamines on the NMDA receptor.
163. The actions of polyamines on NMDA receptors: Electrophysiological and molecular studies.
164. The actions of polyamines on NMDA receptors: Electrophysiological and molecular studies
165. polyamines and the NMDA receptor: Modifying intrinsic activities with aromatic substituents pp 2837–2841
166. Antidepressant-like actions of the polyamine site NMDA antagonist, eliprodil (SL-82.0715)
167. Characterization of polyamines having agonist, antagonist, and inverse agonist effects at the polyamine recognition site of the NMDA receptor
168. Synthetic analogues of conantokin‐G: NMDA antagonists acting through a novel polyamine ‐coupled site
169. An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurones
170. Selective antagonism of native and cloned kainate and NMDA receptors by polyamine -containing toxins.
171. polyamine analogue regulation of NMDA MK-801 binding: A structure− activity study
172. Characterisation of a functional polyamine site on rat mast cells: association with a NMDA receptor macrocomplex
173. Inhibition of the polyamine system counteracts β-amyloid peptide-induced memory impairment in mice: involvement of extrasynaptic NMDA receptors
174. polyamine -like actions of peptides derived from conantokin-G, an N-methyl-D-aspartate (NMDA ) antagonist
175. Molecular features associated with polyamine modulation of NMDA receptors
176. Effects of acamprosate and some polyamine site ligands of NMDA receptor on short-term memory in rats
177. Blockade of the polyamine site of NMDA receptors produces antinociception and enhances the effect of morphine, in mice
178. Effects of ifenprodil, a polyamine site NMDA receptor antagonist, on reperfusion injury after transient focal cerebral ischemia
179. Impact of polyamine Analogs on the NMDA Receptor
180. Radioligand binding studies reveal agmatine is a more selective antagonist for a polyamine -site on the NMDA receptor than arcaine or ifenprodil
181. Combined stimulation of the glycine and polyamine sites of the NMDA receptor attenuates NMDA blockade-induced learning deficits of rats in a 14-unit T-maze
182. polyamine -like actions of aminoglycosides and aminoglycoside derivatives at NMDA receptors
183. polyamine and ifenprodil interactions with the NMDA receptor’s glycine site
184. Effect of ifenprodil, a polyamine site NMDA receptor antagonist, on brain edema formation following asphyxial cardiac arrest in rats
185. A critical importance of polyamine site in NMDA receptors for neurite outgrowth and fasciculation at early stages of P19 neuronal differentiation
186. Potent analgesia induced in rats by combined action at PCP and polyamine recognition sites of the NMDA receptor complex
187. Intrathecal high-dose histamine induces spinally-mediated nociceptive behavioral responses through a polyamine site of NMDA receptors
188. Design, synthesis, and evaluation of polyamine -memantine hybrids as NMDA channel blockers
189. … of the antinociceptive activity of combinations of competitive and non-competitive NMDA antagonists with agents acting at allosteric-glycine and polyamine receptor …
190. polyamine effects on the NMDA receptor in human brain
191. polyamine regulation of the NMDA receptor complex as a target in drug development
192. Exploring the polyamine regulatory site of the NMDA receptor: a parallel synthesis approach
193. polyamine -enhanced NMDA receptor activity: effect of ethanol
194. New polyamine -sensitive inhibitors of the NMDA receptor: Syntheses and pharmacological evaluation
195. Developmental differences in antagonism of NMDA toxicity by the polyamine site antagonist ifenprodil
196. Chronic treatment with the uncompetitive NMDA receptor antagonist memantine influences the polyamine and glycine binding sites of the NMDA receptor complex in …
197. Blockade by polyamine NMDA antagonists related to ifenprodil of NMDA ‐induced synthesis of cyclic GMP, increases in calcium and cytotoxicity in cultured neurones
198. Neuroprotective potential of the polyamine site-directed NMDA receptor antagonists—ifenprodil and eliprodil
199. SL 82.0715, an NMDA antagonist acting at the polyamine site, does not induce neurotoxic effects on rat cortical neurons
200. polyamine sulfonamides with NMDA antagonist properties are potent calmodulin antagonists and cytotoxic agents
201. [125I] Ifenprodil: a convenient radioligand for binding and autoradiographic studies of the polyamine -sensitive site of the NMDA receptor
202. NMDA receptor subtype selectivity: eliprodil, polyamine spider toxins, dextromethorphan, and desipramine selectively block NMDA ‐evoked striatal acetylcholine but …
203. Modification of the philanthotoxin-343 polyamine moiety results in different structure-activity profiles at muscle nicotinic ACh, NMDA and AMPA receptors
204. Inverse agonists at the polyamine -sensitive modulatory site of the NMDA receptor: 50-fold increase in potency by insertion of an aromatic ring into an alkanediamine …
205. The polyamine diaminodecane (DA-10) produces a voltage-dependent flickery block of single NMDA receptor channels
206. Effect of eliprodil, an NMDA receptor antagonist acting at the polyamine modulatory site, on local cerebral glucose use in the rat brain
207. Ornithine decarboxylase inhibition or NMDA receptor antagonism reduce cortical polyamine efflux associated with dialysis probe implantation
208. Effects of the polyamine spermidine on NMDA -induced arterial hypertension in freely moving rats
209. A photoaffinity probe for the polyamine site regulating the NMDA receptor
210. Conantokin-G and its analogs: Novel probes of the NMDA receptor-associated polyamine site
211. Regulation of polyamine and magnesium inhibition of the N-methyl-d-aspartate (NMDA ) receptor ionophore complex
212. The putative polyamine antagonists ifenprodil and SL 82.0715 enhance dopamine efflux from rat striatal slices independent of NMDA receptor activation
213. polyamine ‐enhanced NMDA ‐induced behavioural changes and FOS‐immunoreactivity in rat brain
214. polyamine conjugates as selective NMDA inhibitors and anti-cancer drugs
215. Intracellular polyamine levels are involved in NMDA ‐evoked nitric oxide production in chick retina cells
216. polyamine potentiation and inhibition of NMDA -mediated increases of intracellular free Ca2+ in cultured chick cortical neurons
217. polyamine -sensitive binding of [125I] ifenprodil in washed, frozen-thawed synaptic membranes: evidence for high affinity binding requiring an open NMDA channel
218. Aminooxy-analogues of spermidine: new partial agonists and antagonists at the polyamine site of the rat hippocampal NMDA receptor complex
219. Plasma polyamine changes and possible effects on hypofunctional NMDA receptor found in schlzophrenic brain
220. Chronic neonatal blockade of NMDA receptor does not affect developmental polyamine metabolism but results in altered response to the excitotoxic induction of …
221. Central effects of SL 82.0715, an antagonist of polyamine site of the NMDA receptor complex.
222. NMDA receptors mediate activation of polyamine synthesis and blood-brain barrier breakdown after cold injury
223. Interaction of rigid polyamine analogues with the NMDA receptor complex from rat brain
224. QSAR studies combined with DFT-calculations and Molecular docking of polyamine -sensitive inhibitors of the NMDA receptor
225. An alternative approach to understand schizophrenia: polyamine hypothesis through NMDA receptors
226. polyamine conjugates as selective NMDA inhibitors and anti-cancer drugs
227. Lack of antidepresant-like activity of some ligands of polyamine binding sites of NMDA receptors in models of depression
228. Complex polyamine effects on [3H] MDL 105,519 binding to the NMDA receptor glycine site.
229. … of [3H] 3-((±)-2-carboxypiperazin-4-yl) propyl-1-phosphonic acid ([3H] CPP) binding by ligands acting at the glycine and the polyamine sites of the rat brain NMDA …
230. polyamine -phospholipid complex blocks NMDA -activated currents in vitro
231. Screening for novel ligands at a polyamine recognition domain on the N-methyl-D-aspartate (NMDA ) receptor complex.
232. polyamine spider toxins and NMDA receptors: structural basis for channel block and binding of argiotoxin636
233. Characterization of the polyamine site associated with the N-methyl-D-aspartate (NMDA ) receptor/ionophore complex.
234. (sup 125 I) Ifenprodil: a convenient radioligand for binding and autoradiographic studies of the polyamine -sensitive site of the NMDA receptor
235. Ifenprodil and SL 82.0715 antagonize the effects of NMDA via a polyamine -sensitive modulatory site
236. polyamine -dependent facilitation of postsynaptic AMPA receptors counteracts paired-pulse depression
237. The side effects of antimalarial drugs indicates a polyamine involvement in both schizophrenia and depression
238. COX-2-independent induction of apoptosis by celecoxib and polyamine naphthalimide conjugate mediated by polyamine depression in colorectal cancer cell lines
239. depression of polyamine synthesis in L1210 leukemic mice during treatment with a potent antileukemic agent, 5-azacytidine
240. Lack of antidepresant-like activity of some ligands of polyamine binding sites of NMDA receptors in models of depression
241. Regulatory role of miRNAs in polyamine gene expression in the prefrontal cortex of depressed suicide completers
242. Global gene expression profiling of the polyamine system in suicide completers
243. Evidence of altered polyamine concentrations in cerebral cortex of suicide completers
244. suicide and the polyamine system
245. Effects of histone modifications on increased expression of polyamine biosynthetic genes in suicide
246. Targets of polyamine dysregulation in major depression and suicide : activity-dependent feedback, excitability, and neurotransmission
247. Effects of promoter methylation on increased expression of polyamine biosynthetic genes in suicide
248. Effects of the suicide inhibitors of arginine and ornithine decarboxylase activities on organogenesis, growth, free polyamine and hydroxycinnamoyl putrescine levels in …
249. Susceptibility of Microsporum and Trichophyton species to suicide inhibitors of polyamine biosynthesis
250. polyamine ‐mediated regulation of S‐adenosylmethionine decarboxylase expression in mammalian cells: Studies using 5′‐{[(Z)‐4‐amino‐2‐butenyl]methylamino} …
251. Involvement of the polyamine System in suicide
252. polyamines and suicide risk
253. polyamines, Hydroxycinnamoylputrescines, and Root Formation in Leaf Explants of Tobacco Cultivated in Vitro: Effects of the suicide Inhibitors of Putrescine …
254. Oxidation of polyamines and brain injury
255. Age-related changes in polyamines in memory-associated brain structures in rats
256. polyamines in the brain : distribution, biological interactions, and their potential therapeutic role in brain ischaemia
257. Limited blood‐brain barrier transport of polyamines
258. The role of glia in stress: polyamines and brain disorders
259. polyamines in human brain : regional distribution and influence of aging
260. polyamines in the basal ganglia of human brain . Influence of aging and degenerative movement disorders
261. Effect of deltamethrin on regional brain polyamines and behaviour in young rats
262. A novel role for polyamines in adult neurogenesis in rodent brain
263. Neuronal and glial responses to polyamines in the ischemic brain
264. The regional distribution of the polyamines spermidine and spermine in brain
265. The dynamics of synthesis and degradation of polyamines in normal and regenerating rat liver and brain
266. Short biodegradable polyamines for gene delivery and transfection of brain capillary endothelial cells
267. A quantitative GC‐MS method for three major polyamines in postmortem brain cortex
268. polyamines in brain tumor therapy
269. polyamines in human brain tumors
270. polyamines stimulate mitochondrial calcium transport in rat brain
271. Block of native Ca (2+)‐permeable AMPA receptors in rat brain by intracellular polyamines generates double rectification.
272. Synthesis and biological evaluation of boron-containing polyamines as potential agents for neutron capture therapy of brain tumors
273. Blood brain barrier breakdown in brain edema following cold injury is mediated by microvascular polyamines
274. Boron-containing polyamines as DNA targeting agents for neutron capture therapy of brain tumors: Synthesis and biological evaluation
275. stress-induced dynamic changes in mouse brain polyamines. Role in behavioral reactivity
276. Inhibition of Na, K-ATPase from chick brain by polyamines
277. brain polyamines are controlled by N-methyl-D-aspartate receptors during ischemia and recirculation.
278. Differential response of rat brain polyamines to convulsant agents
279. Cellular and subcellular rat brain spermidine synthase expression patterns suggest region‐specific roles for polyamines, including cerebellar pre‐synaptic function
280. Differential responses of regional brain polyamines followingin utero exposure to synthetic pyrethroid insecticides: A preliminary report
281. polyamines in the developing mouse brain
282. Changes in concentration of polyamines in the developing mouse brain
283. Glia and glial polyamines. Role in brain function in health and disease
284. Depletion of intracellular polyamines may alter DNA conformation in 9L rat brain tumor cells
285. polyamines mediate the reversible opening of the blood-brain barrier by the intracarotid infusion of hyperosmolal mannitol
286. polyamines contribute to calcium-stimulated release of aspartate from brain particulate fractions
287. On the turnover of polyamines spermidine and spermine in mouse brain and other organs
288. polyamines: DEVELOPMENTAL ALTERATIONS IN REGIONAL DISPOSITION AND METABOLISM IN RAT brain 1
289. Metabolism of polyamines and oxidative stress in the brain of cholestatic rats
290. Interrelations between polyamines and nucleic acids: changes of polyamine and nucleic acid concentrations in the developing rat brain
291. … of growth sparing during neonatal nutritional deprivation or enhancement: ornithine decarboxylase, polyamines, and macromolecules in brain regions and heart
292. Effects of polyamines on the uptake of neurotransmitters by rat brain synaptosomes
293. polyamines allosterically modulate [3H] nitrendipine binding to the voltage-sensitive calcium channel in rat brain
294. polyamines and Ca2+ Mediate Hyperosmolal Opening of the Blood‐brain Barrier: In Vitro Studies in Isolated Rat Cerebral Capillaries
295. Accumulation of exogenous polyamines in gerbil brain after ischemia
296. Toxic effects of putrescine in rat brain : polyamines can be involved in the action of excitotoxins
297. polyamines and nucleic acid metabolism during development of chick embryo brain
298. Decreased cytotoxicity of cis-diamminedichloroplatinum (II) by α-difluoromethylornithine depletion of polyamines in 9L rat brain tumor cells in vitro
299. Regulation of the phosphoinositide cascade by polyamines in brain
300. Relationships between GABA and polyamines in developing rat brain
301. Analysis of dansyl derivatives of di-and polyamines in mouse brain , human serum and duodenal biopsy specimens by high-performance liquid chromatography on a …
302. Analysis of histidine-containing dipeptides, polyamines, and related amino acids by high-performance liquid chromatography: Application to guinea pig brain
303. Characterization of serotonin receptors in fish brain : polyamines inhibit the binding process
304. Regulatory interrelations between GABA and polyamines. I. brain GABA levels and polyamine metabolism
305. Effects of polyamines on calcium‐dependent rat brain phosphatidylinositol‐phosphodiesterase
306. Role of polyamines in experience-dependent brain plasticity
307. The research of role of non ureotelic arginases in polyamines biosynthesis in brain and kidney in vitro
308. Effect of polyamines on the stability of brain -cortex ribosomes
309. Interrelationships between polyamines and nucleic acids. III. Metabolic and autoradiographic studies of putrescine in mouse brain
310. polyamines of the human brain during normal fetal and postnatal growth and during postnatal malnutrition
311. Inhibition of glutamate Dehydrogenase in brain Mitochondria and Synaptosomes by Mg2+ and polyamines: A Possible Cause for Its Low In Vivo Activity
312. Effect of dibutyltin dilaurate on regional brain polyamines in rats
313. Interrelationships between polyamines and nucleic acids. Changes of polyamine and nucleic acid concentrations in the growing fish brain (Salmo irideus Gibb.)
314. polyamines increase in the brain stem and cerebellum following labyrinthectomy.
315. CSF polyamines: Potential as brain tumor markers
316. Effects of gestational or neonatal treatment with alpha-difluoromethylornithine on ornithine decarboxylase and polyamines in developing rat brain and on adult rat …
317. Effects of polyamines on proline endopeptidase activity in rat brain
318. Lack of evidence for direct involvement of NMDA receptors or polyamines in blood–brain barrier injury after cerebral ischemia in rats
319. polyamines in rat brain extracellular space after ischemia
320. polyamines in brain and heart of the neontal rat: Effects of inhibitors of ornithine decarboxylase and spermidine synthase
321. Ornithine decarboxylase and polyamines in developing rat brain and heart: Effects of perinatal hypothyroidism
322. Effect of l-arginine on metabolism of polyamines in rat’s brain with extrahepatic cholestasis
323. Acetylation of polyamines in mouse brain : subcellular and regional distribution
324. Complex interactions between polyamines and calpain‐mediated proteolysis in rat brain
325. Cerebrospinal fluid polyamines: biochemical markers of malignant childhood brain tumors
326. Blood levels of polyamines in patients with brain tumor: Special reference to relationship between blood levels of polyamines and histological finding, extension as …
327. The biosynthesis of polyamines in the brain of audiogenic seizure‐susceptible and‐resistant deermice
328. polyamines Differentially Inhibit Cyclic AMP‐Dependent Protein Kinase‐Mediated Phosphorylation in the brain of the Tobacco Hornworm, Manduca sexta
329. Ontogeny of polyamines in relation to nucleic acids in brain and spinal cord of the developing human fetus
330. Stimulation of brain lipase activity by polyamines. Comparison with the effect of ACTH
331. High-resolution capillary gas chromatography in combination with mass spectrometry for quantification of three major polyamines in postmortem brain cortex
332. polyamines modulate [3H] L-689 binding to the glycine site of the NMDA receptor from rat brain
333. Effects of polyamines on amino acid incorporation into protein by cerebral and cerebellar as well as “Neuronal” and “glial” nuclei of rat brain
334. Metabolism of polyamines in normal and scrapie‐affected mouse brain and spleen
335. Increased brain concentrations of polyamines in rats with encephalopathy due to a galactosamine-induced fulminant hepatic failure
336. Multiple phosphorylation of pp30, a rat brain polyribosomal protein, sensitive to polyamines and corticotropin
337. The effect of polyamines on the enzymes of the 4-aminobutyric acid metabolism in mouse brain in vitro
338. Biosynthesis of polyamines in mouse brain : Effects of methionine sulfoximine and adenosylhomocysteine
339. Acetylation of polyamines in chicken brain and retina.
340. Red blood cell polyamines in brain tumour patients
341. Diurnal levels of polyamines and activities of ornithine and S-adenosyl-l-methionine decarboxylases in mouse brain
342. Phosphatidylinositol‐4‐phosphate kinase from rat brain : Activation by polyamines and inhibition by phosphatidylinositol 4, 5‐bisphosphate
343. Role of polyamines in the Control of the Immune Response in the brain
344. Stabilization of neuronal microtubules by polyamines and transglutaminase: its roles in brain function
345. polyamines and the regulation of protein synthesis in brain .
346. brain polyamines and aggressive behavior of isolated mice
347. Rat brain polyamines: an analytical method validation
348. Influence of the naturally occurring polyamines spermine, spermidine and putrescine on the kinetic properties of acetylcholinesterase. Comparative studies with the …
349. polyamines IN THE NORMALLY DEVELOPING MALE AND FEMALE MOUSE brain .
350. … characterization of the binding of (+)-5-methyl-10, 11-dihydro-5H-dibenzo [a, d] cyclohepten-5, 10-imine ([3H] MK-801) in rat brain : regional effects of polyamines.
351. Determination of blood polyamines in patients with brain tumor-with special reference to relationship between varieties of tumors and concentrations of blood …
352. Electrophysiological studies on the brain : Effects of nucleotide and tryptophan metabolites as modified by polyamines in normal and psychotic subjects.
353. Monoamine oxidase activity and brain levels of histamine and polyamines in various extreme exposures
354. The Control of Casein Kinase II Activity and Protein Phosphorylation in the brain of ManducaSexta by polyamines
355. [3H]MK‐801 Binding to N‐Methyl‐d‐Aspartate Receptors Solubilized from Rat brain : Effects of Glycine Site Ligands, polyamines, Ifenprodil, and Desipramine
356. Do polyamines regulate the NMDA inhibition of muscarinic receptor-induced phosphoinositide turnover in guinea pig brain ?
357. … between abilities of a variety of polyamines to increase activator protein-1 DNA binding and to inhibit [3H] spermidine transport in nuclear fractions of murine brain
358. Accumulation of Exogenous polyamines in Gerbil brain After lschemia
359. Free and acetylated polyamines in cyst fluids of brain tumors
360. CSF polyamines in childhood brain tumors.
361. Variations in red blood cell polyamines in brain tumour patients treated with stereotactic radiosurgery
362. Modulation by polyamines of the phosphorylation of the channel-forming cytosol protein of bovine brain
363. The levels of polyamines in autopsy materials of some structures of brain lymbic system and reticular formation of patients with schizophrenia
364. The levels of polyamines in autopsy materials of some structures of brain lymbic system and reticular formation of patients with schizophrenia
365. Effect of hyperoxia on content of the polyamines spermine and spermidine in rat brain and liver
366. Spermine and spermidine polyamines in the brain and liver of rats under hyperoxic action
367. Improved analytical procedure for the measurements of selected biogenic polyamines by HPLC following dabsyl derivatisation in brain tissue
368. Determination of polyamines in samples of human brain , spinal cord, CSF, muscle and muscle microdialysate by precolumn derivatization with 9-fluorenylmethyl …
369. Measurement of blood polyamines in patients with brain tumor–special reference to relationship between the blood levels of spermidine and spermine, and …
370. Activation of brain mitochondrial Ca2+ uptake by polyamines and by Ca2+
371. Activation of brain mitochondrial Ca sup 2+ uptake by polyamines and by Ca sup 2+
372. Metabolism of polyamines in rats’ brain with extrahepatic cholestasis