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Reverses Alcohol-induced Hepatic Steatosis

Alcohol-induced hepatic steatosis, also known as alcoholic fatty liver disease, is the first stage of alcoholic liver disease (ALD). It occurs when the liver metabolizes alcohol and fat builds up in the liver cells, which can impair liver function. This can happen after drinking too much alcohol for as little as two weeks, and about 90% of people who regularly drink excessive amounts of alcohol have fatty liver disease.

  1. Anti-steatotic and anti-inflammatory effects of Hovenia dulcis Thunb. extracts in chronic alcohol-fed rats
  2. Gynura procumbens reverses Acute and Chronic Ethanol-induced Liver steatosis through MAPK/SREBP-1c-Dependent and -Independent Pathways
  3. Understanding the effect of anthocyanin extracted from Lonicera caerulea L. on alcoholic hepatosteatosis
  4. alcohol abstinence rescues hepatic steatosis and liver injury via improving metabolic reprogramming in chronic alcohol-fed mice
  5. Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol–induced hepatic steatosis and cell death in mice
  6. alcohol–induced hepatic steatosis: A comparative study to identify possible indicator (s) of alcoholic fatty liver disease
  7. HIMH0021 attenuates ethanol-induced liver injury and steatosis in mice
  8. Oral intake of chicoric acid reduces acute alcohol–induced hepatic steatosis in mice
  9. Korean Red Ginseng attenuates ethanol-induced steatosis and oxidative stress via AMPK/Sirt1 activation
  10. Asperosaponin VI protects alcohol–induced hepatic steatosis and injury via regulating lipid metabolism and ER stress
  11. Echinacoside ameliorates alcohol–induced oxidative stress and hepatic steatosis by affecting SREBP1c/FASN pathway via PPARα
  12. Methyl ferulic acid attenuates ethanol-induced hepatic steatosis by regulating AMPK and FoxO1 pathways in rats and L-02 cells
  13. Quercetin alleviates ethanol-induced liver steatosis associated with improvement of lipophagy
  14. Scopoletin prevents alcohol–induced hepatic lipid accumulation by modulating the AMPK–SREBP pathway in diet-induced obese mice
  15. Oroxylin A prevents alcohol–induced hepatic steatosis through inhibition of hypoxia inducible factor 1alpha
  16. Root bark of Ulmus davidiana var. japonica restrains acute alcohol–induced hepatic steatosis onset in mice by inhibiting ROS accumulation
  17. Humulus japonicus Extract Ameliorates hepatic steatosis Through the PPARα-Mediated Suppression of alcohol–induced Oxidative Stress
  18. Effect of soyasaponins-rich extract from soybean on acute alcohol–induced hepatotoxicity in mice
  19. Lactobacillus plantarum ZY08 relieves chronic alcohol–induced hepatic steatosis and liver injury in mice via restoring intestinal flora homeostasis
  20. Baicalin ameliorates alcohol–induced hepatic steatosis by suppressing SREBP1c elicited PNPLA3 competitive binding to ATGL
  21. hepatic peroxisome proliferator‐activated receptor gamma signaling contributes to alcohol‐induced hepatic steatosis and inflammation in mice
  22. Betaine in ameliorating alcohol–induced hepatic steatosis
  23. Reversal of ethanol-induced hepatic steatosis and lipid peroxidation by taurine: a study in rats
  24. Depdc5 deficiency exacerbates alcohol–induced hepatic steatosis via suppression of PPARα pathway
  25. Fibroblast growth factor 21 deficiency exacerbates chronic alcohol–induced hepatic steatosis and injury
  26. Ligustrazine prevents alcohol–induced liver injury by attenuating hepatic steatosis and oxidative stress
  27. Mesencephalic astrocyte-derived neurotrophic factor alleviates alcohol induced hepatic steatosis via activating Stat3-mediated autophagy
  28. Monounsaturated fatty acid-enriched olive oil exacerbates chronic alcohol–induced hepatic steatosis and liver injury in C57BL/6J mice
  29. NAMPT overexpression alleviates alcohol–induced hepatic steatosis in mice
  30. Caffeic acid dimethyl ether alleviates alcohol–induced hepatic steatosis via microRNA-378b-mediated CaMKK2-AMPK pathway
  31. Aldehyde dedydrogenase-2 plays a beneficial role in ameliorating chronic alcohol–induced hepatic steatosis and inflammation through regulation of autophagy
  32. Sympathetic overdrive and unrestrained adipose lipolysis drive alcohol–induced hepatic steatosis in rodents
  33. Inhibition of Ghrelin Activity by Receptor Antagonist [d-Lys-3] GHRP-6 Attenuates alcohol–induced hepatic steatosis by Regulating hepatic Lipid Metabolism
  34. miR-203 inhibits alcohol–induced hepatic steatosis by targeting lipin1
  35. A plasma untargeted metabolomic study of Chinese medicine Zhi-Zi-Da-Huang decoction intervention to alcohol–induced hepatic steatosis
  36. Disturbances in the murine hepatic circadian clock in alcohol–induced hepatic steatosis
  37. Gomisin N alleviates ethanol-induced liver injury through ameliorating lipid metabolism and oxidative stress
  38. Ethanol-induced hepatic steatosis is modulated by glycogen level in the liver [S]
  39. Enhanced AMPK phosphorylation contributes to the beneficial effects of Lactobacillus rhamnosus GG supernatant on chronic-alcohol–induced fatty liver disease
  40. Magnesium isoglycyrrhizinate attenuates acute alcohol–induced hepatic steatosis in a zebrafish model by regulating lipid metabolism and ER stress
  41. Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model
  42. Suppression of acute ethanol-induced hepatic steatosis by docosahexaenoic acid is associated with downregulation of stearoyl-CoA desaturase 1 and inflammatory …
  43. Effect of iron on cholesterol 7α-hydroxylase expression in alcohol–induced hepatic steatosis in mice
  44. Hepatoprotective effects of sea cucumber ether-phospholipids against alcohol–induced lipid metabolic dysregulation and oxidative stress in mice
  45. Activation of autophagy attenuates EtOH-LPS-induced hepatic steatosis and injury through MD2 associated TLR4 signaling
  46. Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol–induced steatosis and liver …
  47. Binge Ethanol‐induced HDAC3 Down‐Regulates Cpt1α Expression Leading to hepatic steatosis and Injury
  48. miR-378b regulates insulin sensitivity by targeting insulin receptor and p110α in alcohol–induced hepatic steatosis
  49. Carbohydrate‐responsive element‐binding protein, Sirtuin 1, and ethanol metabolism: A complicated network in alcohol‐induced hepatic steatosis
  50. Quercetin mitigates ethanol-induced hepatic steatosis in zebrafish via P2X7R-mediated PI3K/Keap1/Nrf2 signaling pathway
  51. 1-Methylnicotinamide promotes hepatic steatosis in mice: A potential mechanism in chronic alcohol–induced fatty liver disease
  52. Herbal sgr formula prevents acute ethanol-induced liver steatosis via inhibition of lipogenesis and enhancement fatty acid oxidation in mice
  53. Involvement of AMP-activated protein kinase in beneficial effects of betaine on high-sucrose diet-induced hepatic steatosis
  54. Dietary tomato powder inhibits alcohol–induced hepatic injury by suppressing cytochrome p450 2E1 induction in rodent models
  55. Dysregulation of hepatic cAMP levels via altered Pde4b expression plays a critical role in alcohol‐induced steatosis
  56. Deficiency of NLR family member NLRC5 alleviates alcohol induced hepatic injury and steatosis by enhancing autophagy of hepatocytes
  57. AICAR, an AMPK activator, has protective effects on alcohol‐induced fatty liver in rats
  58. Dietary α-linolenic acid-rich flaxseed oil prevents against alcoholic hepatic steatosis via ameliorating lipid homeostasis at adipose tissue-liver axis in mice
  59. Puerariae Lobatae radix flavonoids and puerarin alleviate alcoholic liver injury in zebrafish by regulating alcohol and lipid metabolism
  60. A combination of Pueraria lobata and Silybum marianum protects against alcoholic liver disease in mice
  61. Inhibition of spleen tyrosine kinase activation ameliorates inflammation, cell death, and steatosis in alcoholic liver disease
  62. Mitochondria-targeted ubiquinone (MitoQ) enhances acetaldehyde clearance by reversing alcohol–induced posttranslational modification of aldehyde …
  63. The function of MGAT1 in alcohol–induced hepatic steatosis and treatment of hepatic steatosis via MGAT1 enzyme inhibition
  64. CYP2E1 potentiates binge alcohol–induced gut leakiness, steatohepatitis, and apoptosis
  65. Nrf2 activation is required for ligustrazine to inhibit hepatic steatosis in alcohol-preferring mice and hepatocytes
  66. The Adiponectin‐SIRT 1‐AMPK Pathway in alcoholic Fatty Liver Disease in the Rat
  67. Lactobacillus fermentum KP-3-fermented ginseng ameliorates alcohol–induced liver disease in C57BL/6N mice through the AMPK and MAPK pathways
  68. Imipramine blocks ethanol-induced ASMase activation, ceramide generation, and PP2A activation, and ameliorates hepatic steatosis in ethanol-fed mice
  69. Antilipogenic and Anti-Inflammatory Activities of Codonopsis lanceolata in Mice hepatic Tissues after Chronic Ethanol Feeding
  70. Binge alcohol–induced microvesicular liver steatosis and injury are associated with down‐regulation of hepatic Hdac 1, 7, 9, 10, 11 and up‐regulation of Hdac 3
  71. Upregulation of 4-hydroxynonenal contributes to the negative effect of n-6 polyunsaturated fatty acid on alcohol–induced liver injury and hepatic steatosis
  72. Immunological Features of alcohol–induced hepatic steatosis
  73. Tangeretin Protects Mice from alcohol–induced Fatty Liver by Activating Mitophagy through the AMPK–ULK1 Pathway
  74. The Edible Insect Gryllus bimaculatus Protects against Gut-Derived Inflammatory Responses and Liver Damage in Mice after Acute alcohol Exposure
  75. Water extract of green tea attenuates alcohol-related hepatitis by inhibiting liver inflammation and gut microbiota disturbance in mice
  76. Aldo-Keto Reductase Family 1 Member A1 (AKR1A1) Deficiency Exacerbates alcohol–induced hepatic Oxidative Stress, Inflammation, steatosis, and Fibrosis
  77. Lactobacillus rhamnosus GG treatment potentiates intestinal hypoxia-inducible factor, promotes intestinal integrity and ameliorates alcohol–induced liver injury
  78. Pathogenic role of phosphodiesterase 4 (pde4) in the development of alcohol induced hepatic steatosis.
  79. CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism
  80. Methyl ferulic acid ameliorates alcohol–induced hepatic insulin resistance via miR-378b-mediated activation of PI3K-AKT pathway
  81. Pharmacological inhibition of NOX4 ameliorates alcohol–induced liver injury in mice through improving oxidative stress and mitochondrial function
  82. Diallyl trisulfide attenuates ethanol-induced hepatic steatosis by inhibiting oxidative stress and apoptosis
  83. HIF-1α induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice
  84. Suppression of PPARγ-mediated monoacylglycerol O-acyltransferase 1 expression ameliorates alcoholic hepatic steatosis
  85. Gut‐restricted apical sodium‐dependent bile acid transporter inhibitor attenuates alcohol‐induced liver steatosis and injury in mice
  86. Low-carbohydrate high-fat dietary pattern ameliorates alcohol-related liver disease via a 6PGD-involved mechanism in mice
  87. Naringin attenuates alcoholic liver injury by reducing lipid accumulation and oxidative stress
  88. Stress‐responsive gene FK506‐Binding protein 51 mediates alcohol‐induced liver injury through the Hippo pathway and chemokine (C‐X‐C Motif) ligand 1 signaling
  89. alcohol–induced CYP2E1, mitochondrial dynamics and retrograde signaling in human hepatic 3D organoids
  90. Melatonin upregulates the activity of AMPK and attenuates lipid accumulation in alcohol–induced rats
  91. Transient receptor potential vanilloid 1 gene deficiency ameliorates hepatic injury in a mouse model of chronic binge alcohol–induced alcoholic liver disease
  92. Dihydroartemisinin protects against alcoholic liver injury through alleviating hepatocyte steatosis in a farnesoid X receptor-dependent manner
  93. Transgenic overexpression of CTRP3 prevents alcohol–induced hepatic triglyceride accumulation
  94. Lactobacillus rhamnosus GG reduces hepatic TNFα production and inflammation in chronic alcohol–induced liver injury
  95. Ginsenoside Rb1 alleviates alcohol–induced liver injury by inhibiting steatosis, oxidative stress, and inflammation
  96. Hepatoprotective potential of Aloe vera polysaccharides against chronic alcohol‐induced hepatotoxicity in mice
  97. Blueberry polyphenols play a preventive effect on alcoholic fatty liver disease C57BL/6 J mice by promoting autophagy to accelerate lipolysis to eliminate …
  98. Therapeutic benefits of spleen tyrosine kinase inhibitor administration on binge drinking‐induced alcoholic liver injury, steatosis, and inflammation in mice
  99. Dietary fisetin supplementation protects against alcohol‐induced liver injury in mice
  100. Genistein Protects against Acetaldehyde-induced Oxidative Stress and Hepatocyte Injury in Chronic alcohol-Fed Mice
  101. Aldehyde Dehydrogenase-2 (ALDH2) Ameliorates Chronic alcohol Ingestion-induced hepatic steatosis and Inflammation: Role of Autophagy
  102. Activation of PPARα-catalase pathway reverses alcoholic liver injury via upregulating NAD synthesis and accelerating alcohol clearance
  103. Molecular mechanism of alcoholic fatty liver
  104. Naringenin inhibits alcoholic injury by improving lipid metabolism and reducing apoptosis in zebrafish larvae
  105. Shanxi aged vinegar protects against alcohol–induced liver injury via activating Nrf2-mediated antioxidant and inhibiting TLR4-induced inflammatory response
  106. Dihydromyricetin modulates p62 and autophagy crosstalk with the Keap-1/Nrf2 pathway to alleviate ethanol-induced hepatic injury
  107. ZFP36L1 regulates Fgf21 mRNA turnover and modulates alcoholic hepatic steatosis and inflammation in mice
  108. In vivo hepatoprotective effects of a peptide fraction from krill protein hydrolysates against alcohol–induced oxidative damage
  109. TLR9 signaling protects alcohol–induced hepatic oxidative stress but worsens liver inflammation in mice
  110. Salvianolic acid B protects against chronic alcoholic liver injury via SIRT1-mediated inhibition of CRP and ChREBP in rats
  111. microRNA-378b regulates ethanol-induced hepatic steatosis by targeting CaMKK2 to mediate lipid metabolism
  112. Protective effects of oyster extract against hepatic tissue injury in alcoholic liver diseases
  113. The role of lipid metabolism in the pathogenesis of alcoholic and nonalcoholic hepatic steatosis
  114. The inhibitory effect of ethanol on Sestrin3 in the pathogenesis of ethanol-induced liver injury
  115. The study of Yin-Chen-Hao-Tang preventing and treating alcoholic fatty liver disease through PPAR signaling pathway based on network pharmacology and …
  116. Metagenomic Analyses of alcohol induced Pathogenic Alterations in the Intestinal Microbiome and the Effect of Lactobacillus rhamnosus GG Treatment
  117. Berberine Ameliorates Abnormal Lipid Metabolism via the Adenosine Monophosphate–Activated Protein Kinase/Sirtuin 1 Pathway in alcohol-Related Liver Disease
  118. Chronic alcohol exposure alters circulating insulin and ghrelin levels: role of ghrelin in hepatic steatosis
  119. Obeticholic acid ameliorates valproic acid–induced hepatic steatosis and oxidative stress
  120. Activation of AhR-NQO1 signaling pathway protects against alcohol–induced liver injury by improving redox balance
  121. Roxadustat, a hypoxia-inducible factor 1α activator, attenuates both long-and short-term alcohol–induced alcoholic liver disease
  122. Loss of ERdj5 exacerbates oxidative stress in mice with alcoholic liver disease via suppressing Nrf2
  123. Ghrelin regulates adipose tissue metabolism: Role in hepatic steatosis
  124. Dihydroartemisinin attenuates alcoholic fatty liver through regulation of lipin‐1 signaling
  125. Reduced Susceptibility of DNA Methyltransferase 1 Hypomorphic (Dnmt1N/+) Mice to hepatic steatosis upon Feeding Liquid alcohol Diet
  126. Synergistic Protective Effect of Fermented Schizandrae Fructus Pomace and Hoveniae Semen cum Fructus Extracts Mixture in the Ethanol-induced Hepatotoxicity
  127. Liver kinase B1/AMP‐activated protein kinase‐mediated regulation by gentiopicroside ameliorates P2X7 receptor‐dependent alcoholic hepatosteatosis
  128. D-Mannose Regulates Hepatocyte Lipid Metabolism via PI3K/Akt/mTOR Signaling Pathway and Ameliorates hepatic steatosis in alcoholic Liver Disease
  129. RAGE promotes dysregulation of iron and lipid metabolism in alcoholic liver disease
  130. Silkworm (Bombyx mori) powder supplementation alleviates alcoholic fatty liver disease in rats
  131. Adipose-specific lipin1 overexpression in mice protects against alcohol–induced liver injury
  132. Loss of long-chain acyl-CoA synthetase 1 promotes hepatocyte death in alcohol–induced steatohepatitis
  133. Dietary agents in the prevention of alcohol–induced hepatotoxicty: preclinical observations
  134. Acrolein is a pathogenic mediator of alcoholic liver disease and the scavenger hydralazine is protective in mice
  135. alcoholic-induced hepatic steatosis—role of ceramide and protein phosphatase 2A
  136. Betaine attenuates alcohol–induced pancreatic steatosis
  137. hepatic NCoR1 deletion exacerbates alcohol–induced liver injury in mice by promoting CCL2-mediated monocyte-derived macrophage infiltration
  138. Polydatin alleviated alcoholic liver injury in zebrafish larvae through ameliorating lipid metabolism and oxidative stress
  139. hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol–induced liver injury in mice
  140. Intestinal HIF-1α deletion exacerbates alcoholic liver disease by inducing intestinal dysbiosis and barrier dysfunction
  141. Immunometabolic Cross-Talk and Regulation of Endocrine and Metabolic Functions: Transgenic overexpression of CTRP3 prevents alcohol–induced hepatic …
  142. Glucagon-like peptide 1 receptor agonist, exendin-4, reduces alcohol-associated fatty liver disease
  143. Dietary camellia seed oil attenuates liver injury in mice chronically exposed to alcohol
  144. A Corn Oil–Based Diet Protects Against Combined Ethanol and Iron‐induced Liver Injury in a Mouse Model of Hemochromatosis
  145. Inhibition of cereblon by fenofibrate ameliorates alcoholic liver disease by enhancing AMPK
  146. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease
  147. The epigenetic regulator SIRT6 protects the liver from alcohol–induced tissue injury by reducing oxidative stress in mice
  148. Therapeutic potential of Chinese herbal medicines in alcoholic liver disease
  149. p53 protects against alcoholic fatty liver disease via ALDH2 inhibition
  150. Activation of carbohydrate response element-binding protein by ethanol
  151. Inhibition of hepatotoxicity by a LXR inverse agonist in a model of alcoholic liver disease
  152. Neuronal modulation of hepatic lipid accumulation induced by bingelike drinking
  153. The effect of taurine depletion by β-alanine treatment on the susceptibility to ethanol-induced hepatic dysfunction in rats
  154. Adiponectin deficiency rescues high-fat diet-induced hepatic injury, apoptosis and autophagy loss despite persistent steatosis
  155. Oyster protein hydrolysates alleviated chronic alcohol–induced liver injury in mice by regulating hepatic lipid metabolism and inflammation response
  156. Dietary linoleic acid and its oxidized metabolites exacerbate liver injury caused by ethanol via induction of hepatic proinflammatory response in mice
  157. Nrf2 knockdown disrupts the protective effect of curcumin on alcohol–induced hepatocyte necroptosis
  158. S100a16 Deficiency Prevents alcohol–induced Fatty Liver Injury via Inducing MANF Expression in Mice
  159. Trehalose activates hepatic transcription factor EB (TFEB) but fails to ameliorate alcohol‐impaired TFEB and liver injury in mice
  160. Walnut (Juglans regia L.) Oligopeptides Alleviate alcohol–induced Acute Liver Injury through the Inhibition of Inflammation and Oxidative Stress in Rats
  161. Anti‐inflammatory and anti‐apoptotic roles of endothelial cell STAT3 in alcoholic liver injury
  162. Suppression of endoplasmic reticulum stress-associated pathways and hepatocyte apoptosis participates in the attenuation of betulinic acid on alcohol-provoked liver …
  163. Deletion of Gab2 in mice protects against hepatic steatosis and steatohepatitis: a novel therapeutic target for fatty liver disease
  164. β-Lapachone alleviates alcoholic fatty liver disease in rats
  165. Cranberry (Vaccinium macrocarpon) peel polyphenol-rich extract attenuates rat liver mitochondria impairments in alcoholic steatohepatitis in vivo and after oxidative …
  166. Involvement and mechanism of DGAT2 upregulation in the pathogenesis of alcoholic fatty liver disease
  167. Metformin protects against ethanol-induced liver triglyceride accumulation by the LKB1/AMPK/ACC pathway
  168. Ginsenoside rc modulates SIRT6-NRF2 interaction to alleviate alcoholic liver disease
  169. Lipophagy and alcohol–induced fatty liver
  170. Purinergic P2X7 receptor blockade mitigates alcohol–induced steatohepatitis and intestinal injury by regulating MEK1/2-ERK1/2 signaling and egr-1 activity
  171. Hepatoprotective effects of curcumin in alcohol–induced hepatotoxicity: a memoir on the preclinical studies
  172. DNA-PKcs promotes alcohol-related liver disease by activating Drp1-related mitochondrial fission and repressing FUNDC1-required mitophagy
  173. Delayed ethanol elimination and enhanced susceptibility to ethanol-induced hepatosteatosis after liver resection
  174. Ganoderic acids-rich ethanol extract from Ganoderma lucidum protects against alcoholic liver injury and modulates intestinal microbiota in mice with …
  175. Essential role of IFN-γ in regulating gut antimicrobial peptides and microbiota to protect against alcohol–induced bacterial translocation and hepatic …
  176. Ceramide synthase 6 (CerS6) is upregulated in alcohol-associated liver disease and exhibits sex-based differences in the regulation of energy homeostasis and lipid …
  177. Transgenic overexpression of CTRP3 prevents alcohol–induced hepatic triglyceride accumulation 2 Greta Trogen1, Joshua Bacon1, Ying Li2, Gary L. Wright2, Ashley …
  178. Persistent mTORC1 activation via Depdc5 deletion results in spontaneous hepatocellular carcinoma but does not exacerbate carcinogen-and high-fat diet-induced …
  179. Mechanisms and intervention strategies for alcohol and HIV-antiretroviral therapy-induced liver injury.
  180. Hepatocyte-derived MANF mitigates ethanol-induced liver steatosis in mice via enhancing ASS1 activity and activating AMPK pathway
  181. Heme oxygenase-1 alleviates alcoholic liver steatosis: histopathological study
  182. PCSK9 inhibition as a novel therapeutic target for alcoholic liver disease
  183. The role of MLKL in hepatic Ischemia-Reperfusion Injury of alcoholic Steatotic Livers
  184. Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol–induced intestinal permeability and liver injury
  185. New insights in the pathogenesis of alcohol-related liver disease: the metabolic, immunologic, and neurologic pathways☆
  186. Echinacea purpurea polysaccharide prepared by fractional precipitation prevents alcoholic liver injury in mice by protecting the intestinal barrier and regulating liver …
  187. Inhibition of aldose reductase ameliorates alcoholic liver disease by activating AMPK and modulating oxidative stress and inflammatory cytokines
  188. Intestinal ELF4 deletion exacerbates alcoholic liver disease by disrupting gut homeostasis
  189. SREBP1c mediates the effect of acetaldehyde on Cidea expression in alcoholic fatty liver Mice
  190. Red mulberry fruit aqueous extract and silk proteins accelerate acute ethanol metabolism and promote the anti‑oxidant enzyme systems in rats
  191. Anthocyanin-Rich Extract of Red Cabbage Attenuates Advanced alcohol Hepatotoxicity in Rats in Association with Mitochondrial Activity Modulation
  192. Chronic ethanol consumption-induced hepatotoxicity and protective effect of Boswellia serrata
  193. Artemisia Iwayomogi Extract Attenuates High-Fat Diet-induced Hypertriglyceridemia in Mice: Potential Involvement of the Adiponectin-AMPK Pathway and Very Low …
  194. Role of mechanistic target of rapamycin and autophagy in alcohol–induced adipose atrophy and liver injury
  195. Costunolide protects against alcohol‐induced liver injury by regulating gut microbiota, oxidative stress and attenuating inflammation in vivo and in vitro
  196. The role of ceramide in the pathogenesis of alcoholic liver disease
  197. DRAM1 increases the secretion of PKM2-enriched EVs from hepatocytes to promote macrophage activation and disease progression in ALD
  198. Inhibition of heat shock protein 90 alleviates steatosis and macrophage activation in murine alcoholic liver injury
  199. Intestinal epithelial β klotho is a critical protective factor in alcohol–induced intestinal barrier dysfunction and liver injury
  200. Natural products, extracts and formulations comprehensive therapy for the improvement of motor function in alcoholic liver disease
  201. Iron oxide nanoparticles aggravate hepatic steatosis and liver injury in nonalcoholic fatty liver disease through BMP-SMAD-mediated hepatic iron overload
  202. Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice
  203. Pharmacological chaperone therapies: Can aldehyde dehydrogenase activator make us healthier?
  204. alcoholic, nonalcoholic, and toxicant-associated steatohepatitis: mechanistic similarities and differences
  205. Defect of mitochondrial respiratory chain is a mechanism of ROS overproduction in a rat model of alcoholic liver disease: role of zinc deficiency
  206. Fibroblast growth factor 21 is required for the therapeutic effects of Lactobacillus rhamnosus GG against fructose-induced fatty liver in mice
  207. Enhanced Ca2+-channeling complex formation at the ER-mitochondria interface underlies the pathogenesis of alcohol-associated liver disease
  208. Dihydroartemisinin protects against alcoholic liver injury through alleviating
  209. Bifidobacterium breve ATCC15700 pretreatment prevents alcoholic liver disease through modulating gut microbiota in mice exposed to chronic alcohol intake
  210. Effect of ethanol on lipid metabolism
  211. Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy
  212. Cholesterol Regulation by Leptin in alcoholic Liver Disease
  213. Hepatoprotective potential of partially hydrolyzed guar gum against acute alcohol–induced liver injury in vitro and vivo
  214. The critical role of redox regulation of PTEN and peroxiredoxin III in alcoholic fatty liver
  215. Ginseng (Panax ginseng Meyer) Oligopeptides Protect Against Binge Drinking-induced Liver Damage through Inhibiting Oxidative Stress and Inflammation in Rats
  216. Lactobacillus plantarum LC27 and Bifidobacterium longum LC67 mitigate alcoholic steatosis in mice by inhibiting LPS-mediated NF-κB activation through restoration …
  217. Oxidation of fish oil exacerbates alcoholic liver disease by enhancing intestinal dysbiosis in mice
  218. Perilipin 5 protects the mitochondrial oxidative functions and improves the alcoholic liver injury in mice
  219. Metformin Ameliorates Ethanol-induced Liver Triglyceride Accumulation by LKB1/AMPK/ACC Pathway
  220. Dietary β-conglycinin prevents acute ethanol-induced fatty liver in mice
  221. alcoholic liver disease-from steatosis to cirrhosis-a biochemistry approach
  222. Chronic alcohol consumption has a biphasic effect on hepatic retinoid loss
  223. Metabolomics Study of Serum from a Chronic alcohol-Fed Rat Model Following Administration of Defatted Tenebrio molitor Larva Fermentation Extract
  224. Loss of SQSTM1/p62 Induces Obesity and Exacerbates alcohol–induced Liver Injury in Aged Mice
  225. Hesperidin protects against acute alcoholic injury through improving lipid metabolism and cell damage in zebrafish larvae
  226. Liver-specific Nrf2 deficiency accelerates ethanol-induced lethality and hepatic injury in vivo
  227. Transcriptomic Analysis Reveals Lactobacillus reuteri Alleviating alcohol–induced Liver Injury in Mice by Enhancing the Farnesoid X Receptor Signaling Pathway
  228. CTRP3 and alcoholic Liver Disease in Female Mice
  229. Activation of peroxisome proliferator-activated receptor-γ by rosiglitazone improves lipid homeostasis at the adipose tissue-liver axis in ethanol-fed mice
  230. Regulation of NOX/p38 MAPK/PPARα pathways and miR-155 expression by boswellic acids reduces hepatic injury in experimentally-induced alcoholic liver disease …
  231. Role of phosphodiesterase-4 in alcohol–induced organ injury.
  232. Protection of LP-cs on acute alcohol–induced liver and intestine injury
  233. Chronic alcohol Consumption Causes Liver Injury in High‐Fructose‐Fed Male Mice Through Enhanced hepatic Inflammatory Response
  234. Glutamate signaling in hepatic stellate cells drives alcoholic steatosis
  235. Inhibition of HMGB1/TLR4 signaling pathway by digitoflavone: a potential therapeutic role in alcohol-associated liver disease
  236. Dietary Bacillus subtilis supplementation alleviates alcohol‑induced liver injury by maintaining intestinal integrity and gut microbiota homeostasis in mice
  237. Ginsenoside Rg1 inhibits inflammatory responses via modulation of the nuclear factor‑κB pathway and inhibition of inflammasome activation in alcoholic hepatitis
  238. Gender differences in early alcohol–induced liver injury: role of CD14, NF-κB, and TNF-α
  239. Fuzhuan brick tea ameliorates hepatic steatosis and steatohepatitis through gut microbiota-derived aryl hydrocarbon receptor ligands in high-fat diet-induced obese …
  240. Promotion of autophagosome–lysosome fusion via salvianolic acid A-mediated SIRT1 up-regulation ameliorates alcoholic liver disease
  241. Probiotics counteract hepatic steatosis caused by ketogenic diet and upregulate AMPK signaling in a model of infantile epilepsy
  242. Combination of s-methyl cysteine and protocatechuic acid provided greater lipid-lowering and anti-inflammatory effects in mice liver against chronic alcohol …
  243. Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease
  244. Protective Effect of Probiotic in alcohol–induced Liver Disorders: Role of Probiotics in alcohol–induced Liver Disorders
  245. Nanoformulated SOD1 ameliorates the combined NASH and alcohol-associated liver disease partly via regulating CYP2E1 expression in adipose tissue and liver
  246. alcohol–induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcohol-related liver disease
  247. Diallyl trisulfide protects against ethanol-induced oxidative stress and apoptosis via a hydrogen sulfide-mediated mechanism
  248. Absolute quantitative lipidomics reveals lipids profiling in liver of mice with early-stage alcoholic liver disease
  249. Genetically encoded probiotic EcN 1917 alleviates alcohol–induced acute liver injury and restore gut microbiota homeostasis
  250. Linking dysregulated AMPK signaling and ER stress in ethanol-induced liver injury in hepatic alcohol dehydrogenase deficient deer mice
  251. Contrasting effects of fasting on liver-adipose axis in alcohol-associated and non-alcoholic fatty liver
  252. MicroRNA-29b ameliorates hepatic inflammation via suppression of STAT3 in alcohol-associated liver disease
  253. Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy
  254. alcoholic liver disease: A current molecular and clinical perspective
  255. Therapy of NAFLD: antioxidants and cytoprotective agents
  256. The role of SHP/REV-ERBα/CYP4A axis in the pathogenesis of alcohol-associated liver disease
  257. Adipose tissue autophagy and homeostasis in alcohol–induced liver injury
  258. Physcion alleviates chronic alcoholic hepatic inflammation and pyroptosis through SIRT1-AMPK activation
  259. Protective effects of cichoric acid on H2O2-induced oxidative injury in hepatocytes and larval zebrafish models
  260. Oroxylin A regulates the turnover of lipid droplet via downregulating adipose triglyceride lipase (ATGL) in hepatic stellate cells
  261. Site‐specific identification and validation of hepatic histone nitration in vivo: Implications for alcohol‐induced liver injury
  262. Comprehensive analysis of the expression profiles of hepatic lncRNAs in the mouse model of alcoholic liver disease
  263. Compound probiotic ameliorates acute alcoholic liver disease in mice by modulating gut microbiota and maintaining intestinal barrier
  264. Lipid droplet dynamics in alcoholic fatty liver disease
  265. Protective mechanism of edible food plants against alcoholic liver disease with special mention to polyphenolic compounds
  266. Anti-inflammatory and hepatoprotective effects of exopolysaccharides isolated from Pleurotus geesteranus on alcohol–induced liver injury
  267. Role of gut bacterial and non-bacterial microbiota in alcohol-associated liver disease: Molecular mechanisms, biomarkers, and therapeutic prospective
  268. Qinggan Huoxue Recipe Protects against Experimental alcoholic Liver Fibrosis through CXCL16 Inhibition
  269. Decreasing phosphatidylcholine on the surface of the lipid droplet correlates with altered protein binding and steatosis
  270. Is cannabidiol hepatotoxic or hepatoprotective: A review
  271. Indole-3-acetamide from gut microbiota activated hepatic AhR and mediated the remission effect of Lactiplantibacillus plantarum P101 on alcoholic liver injury in mice
  272. Protection of Inonotus hispidus (Bull.) P. Karst. against Chronic alcohol–induced Liver Injury in Mice via Its Relieving Inflammation Response
  273. Dissociation between diurnal cycles in locomotor activity, feeding behavior and hepatic PERIOD2 expression in chronic alcohol-fed mice
  274. Effect of taurine on alcoholic liver disease in rats
  275. Role of autophagy and regulatory mechanisms in alcoholic cardiomyopathy
  276. Protective effects of probiotics on acute alcohol–induced liver injury in mice through alcohol metabolizing enzymes activation and hepatic TNF-α response reduction
  277. An overview of the mechanism of Penthorum chinense Pursh on alcoholic fatty liver
  278. Glutamate/metabotropic glutamate receptor-5 signaling in hepatic stellate cells drives endocannabinoid-mediated alcoholic steatosis
  279. Distinct histopathological phenotypes of severe alcoholic hepatitis suggest different mechanisms driving liver injury and failure
  280. Plant-based foods and their bioactive compounds on fatty liver disease: Effects, mechanisms, and clinical application
  281. FGF21 induced by carbon monoxide mediates metabolic homeostasis via the PERK/ATF4 pathway
  282. P2X7 receptor‐targeted regulation by tetrahydroxystilbene glucoside in alcoholic hepatosteatosis: A new strategy towards macrophage–hepatocyte crosstalk
  283. alcohol–induced liver injury in signalling pathways and curcumin’s therapeutic potential
  284. Role of mitochondria in alcoholic liver disease
  285. Total saponins from Panax japonicus attenuate acute alcoholic liver oxidative stress and hepatosteatosis by p62-related Nrf2 pathway and AMPK-ACC/PPARα axis in …
  286. Hepatitis B virus X protein induces ALDH2 ubiquitin-dependent degradation to enhance alcoholic steatohepatitis
  287. alcohol induces more severe fatty liver disease by influencing cholesterol metabolism
  288. Acrolein Is a Pathogenic Mediator of alcoholic Liver Disease and the Scavenger Hydralazine Is Protective in Mice
  289. Liver iron loading in alcohol-associated liver disease
  290. Profiling of polar metabolites in mouse feces using four analytical platforms to study the effects of cathelicidin-related antimicrobial peptide in alcoholic liver disease
  291. Role of Adipose Lipolysis in Development of alcoholic Liver Disease
  292. hepatic regulator of G protein signaling 6 (RGS6) drives non-alcoholic fatty liver disease by promoting oxidative stress and ATM-dependent cell death
  293. alcohol and liver clock disruption increase small droplet macrosteatosis, alter lipid metabolism and clock gene mRNA rhythms, and remodel the triglyceride lipidome …
  294. Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury
  295. Dysregulation of hepatic zinc transporters in a mouse model of alcoholic liver disease
  296. Emerging roles of SIRT1 in fatty liver diseases
  297. Resveratrol alleviates alcoholic fatty liver in mice
  298. The murine hepatic sequelae of long-term ethanol consumption are sex-specific and exacerbated by Aldh1b1 loss
  299. Taxifolin ameliorate high-fat-diet feeding plus acute ethanol binge-induced steatohepatitis through inhibiting inflammatory caspase-1-dependent pyroptosis
  300. Protective effects of lactic acid bacteria against TLR4 induced inflammatory response in hepatoma HepG2 cells through modulation of toll-like receptor negative …
  301. Role of cAMP and phosphodiesterase signaling in liver health and disease
  302. Blocking alcoholic steatosis in mice with a peripherally restricted purine antagonist of the type 1 cannabinoid receptor
  303. The methyl donor S-adenosylmethionine prevents liver hypoxia and dysregulation of mitochondrial bioenergetic function in a rat model of alcohol–induced …
  304. Levilactobacillus brevis MG5311 Alleviates Ethanol-induced Liver Injury by Suppressing hepatic Oxidative Stress in C57BL/6 Mice
  305. Mechanism for prevention of alcohol–induced liver injury by dietary methyl donors
  306. Inhibition of vascular endothelial growth factor signaling facilitates liver repair from acute ethanol-induced injury in zebrafish
  307. Cheong-sang-bang-pung-san alleviated hepatic lipid accumulation by regulating lipid metabolism in vitro and in vivo
  308. Iron and iron-related proteins in alcohol consumers: cellular and clinical aspects
  309. Ginsenoside Rg2 ameliorating CDAHFD-induced hepatic fibrosis by regulating AKT/mTOR-mediated autophagy
  310. Fructooligosaccharides and galactooligosaccharides improve hepatic steatosis via gut microbiota-brain axis modulation
  311. Diverse consequences in liver injury in mice with different autophagy functional status treated with alcohol
  312. The longitudinal effect of the aldehyde dehydrogenase 2* 2 allele on the risk for nonalcoholic fatty liver disease
  313. Apple Consumption Protects against Acute Ethanol-induced Liver Injury in Rats
  314. Liver and Biliary Tract Physiology/Pathophysiology: Nanoformulated SOD1 ameliorates the combined NASH and alcohol-associated liver disease partly via …
  315. Acrolein is a critical mediator of alcohol–induced liver and intestinal injury in alcoholic liver disease.
  316. Vinyl chloride-induced interaction of nonalcoholic and toxicant-associated steatohepatitis: Protection by the ALDH2 activator Alda-1
  317. Defect of mitochondrial respiratory chain is a mechanism of ROS overproduction in a rat 1
  318. Dysregulated phosphorylation and nuclear translocation of cyclic AMP response element binding protein (CREB) in rat liver after chronic ethanol binge
  319. Protective effect of Lactobacillus rhamnosus GG and its supernatant against myocardial dysfunction in obese mice exposed to intermittent hypoxia is …
  320. Liver metabolomics identifies bile acid profile changes at early stages of alcoholic liver disease in mice
  321. hepatic cannabinoid signaling in the regulation of alcohol-associated liver disease
  322. Lemon balm and dandelion leaf extracts synergistically protect against carbon tetrachloride-induced acute liver injury in mice
  323. Hepatocyte-specific loss of PPARγ protects mice from NASH and increases the therapeutic effects of rosiglitazone in the liver
  324. Nrf2 in alcoholic liver disease
  325. NAMPT-mediated NAD+ biosynthesis suppresses activation of hepatic stellate cells and protects against CCl4-induced liver fibrosis in mice
  326. Soyasaponin A2 Alleviates Steatohepatitis Possibly through Regulating Bile Acids and Gut Microbiota in the Methionine and Choline‐Deficient (MCD) Diet‐induced …
  327. Stimulation of fat accumulation in hepatocytes by PGE2-dependent repression of hepatic lipolysis, β-oxidation and VLDL-synthesis
  328. Novel in vitro model for combined effects of alcohol and free fatty acids on hepatocellular lipid accumulation and inflammation
  329. Endogenous mitochondrial aldehyde dehydrogenase-2 as an antioxidant in liver
  330. Metabolic profiling of CB1 neutral antagonists
  331. Targeting the gut barrier for the treatment of alcoholic liver disease
  332. Fatty liver disease caused by high-alcohol-producing Klebsiella pneumoniae
  333. alcohol and lipid metabolism
  334. Focus on emerging drugs for the treatment of patients with non-alcoholic fatty liver disease
  335. Cannabinoids and Chronic Liver Diseases
  336. The role of hypoxia-inducible factor 1α in hepatic lipid metabolism
  337. Involvement of mammalian sirtuin 1 in the action of ethanol in the liver
  338. 24-Norursodeoxycholic acid ameliorates experimental alcohol-related liver disease and activates hepatic PPARγ
  339. Serum metabolomic profiling identifies key metabolic signatures associated with pathogenesis of alcoholic liver disease in humans
  340. Benefits of Combining Sonchus brachyotus DC. Extracts and Synbiotics in Alleviating Non-alcoholic Fatty Liver Disease
  341. Promoting intestinal antimicrobial defense and microbiome symbiosis contributes to IL-22-mediated protection against alcoholic hepatitis in mice
  342. Qinggan Huoxue Recipe attenuates alcoholic Liver Disease by suppressing PI3K/AKT signaling pathway based on network pharmacology
  343. The effect of alcohol on body composition
  344. Kinsenoside alleviates alcoholic liver injury by reducing oxidative stress, inhibiting endoplasmic reticulum stress, and regulating AMPK-dependent autophagy
  345. Advances in traditional Chinese medicine for liver disease therapy in 2021
  346. Hawk tea flavonoids as natural hepatoprotective agents alleviate acute liver damage by reshaping the intestinal microbiota and modulating the Nrf2 and NF-κB …
  347. Microsomal ethanol‐oxidizing system (MEOS): the first 30 years (1968‐1998)–a review
  348. Autophagy, Oxidative Stress, and alcoholic Liver Disease: A Systematic Review and Potential Clinical Applications
  349. Emerging roles of impaired autophagy in fatty liver disease and hepatocellular carcinoma
  350. Mangiferin improves hepatic damage-associated molecular patterns, lipid metabolic disorder and mitochondrial dysfunction in alcohol hepatitis rats
  351. Aldehyde dehydrogenase 2 deficiency negates chronic low-to-moderate alcohol consumption-induced cardioprotecion possibly via ROS-dependent …
  352. Inhibitory effect of ethanol on AMPK phosphorylation is mediated in part through elevated ceramide levels
  353. Etracellular vesicles from lactobacillus rhamnosus GG protect against alcohol–induced liver injury through suppression of intestinal MIR 194 and subsequent activation …
  354. G protein-coupled receptors as potential targets for nonalcoholic fatty liver disease treatment
  355. Echinacea in hepatopathy: A review of its phytochemistry, pharmacology, and safety
  356. Protective Effects of Three Flavonoids from Dendrobium huoshanense Flowers on alcohol‐induced Hepatocyte Injury via Activating Nrf2 and Inhibiting NF‐κB …
  357. Curcumol Suppresses CCF-Mediated Hepatocyte Senescence Through Blocking LC3B–Lamin B1 Interaction in alcoholic Fatty Liver Disease
  358. The potential effects of HECTD4 variants on fasting glucose and triglyceride levels in relation to prevalence of type 2 diabetes based on alcohol intake
  359. Ruichao Yue 1, Xiaoyuan Wei2, Jiangchao Zhao2, Zhanxiang Zhou1, 3 and Wei Zhong1, 3
  360. The Role of Phosphohistidine Phosphatase 1 in Ethanol-induced Liver Injury
  361. Olanzapine induces SREBP-1-related adipogenesis in 3T3-L1 cells
  362. Emerging roles of sirtuins in alleviating alcoholic liver disease: a comprehensive review
  363. Characterization of Adipose Tissue Inflammation in alcoholic Liver Disease
  364. Pathogenesis, early diagnosis, and therapeutic management of alcoholic liver disease
  365. Deciphering the impact and mechanism of Trikatu, a spices-based formulation on alcoholic liver disease employing network pharmacology analysis and in …
  366. Increased plasma corticosterone contributes to the development of alcoholic fatty liver in mice
  367. Augmented liver inflammation in a microsomal prostaglandin E synthase 1 (mPGES-1)-deficient diet-induced mouse NASH model
  368. Downregulation of proinflammatory liver gene expression by Justicia spicigera and kaempferitrin in a murine model of obesity-induced by a high-fat diet
  369. Interleukin-6 signal transduction and its role in hepatic lipid metabolic disorders
  370. Mechanisms, biomarkers and targets for therapy in alcohol-associated liver injury: from genetics to nutrition: summary of the ISBRA 2018 symposium
  371. Carboxylesterase 1 plays a protective role against metabolic disease
  372. Mesencephalic astrocyte‐derived neurotrophic factor alleviates non‐alcoholic steatohepatitis induced by Western diet in mice
  373. Knockdown of GBP5 alleviates lipid accumulation and inflammation in alcoholic fatty liver through inhibition of NF-κB pathway in mice
  374. Distinct metabolic adaptation of liver circadian pathways to acute and chronic patterns of alcohol intake
  375. Insulin sensitivity of hepatic glucose and lipid metabolism in animal models of hepatic steatosis
  376. Protective Effect of Polyphenols, Protein, Peptides, and Polysaccharides on alcoholic Liver Disease: A Review of Research Status and Molecular Mechanisms
  377. Circ_1639 induces cells inflammation responses by sponging miR-122 and regulating TNFRSF13C expression in alcoholic liver disease
  378. ALDH2 protects against alcoholic cardiomyopathy through a mechanism involving the p38 MAPK/CREB pathway and local renin-angiotensin system inhibition in …
  379. Perfluorooctane sulfonate‐induced apoptosis in kidney cells by triggering the NOX4/ROS/JNK axis and antagonism of cannabidiol
  380. Lactobacillus plantarum ZJUIDS14 alleviates non-alcoholic fatty liver disease in mice in association with modulation in the gut microbiota
  381. Endocrine factors associated with non-alcoholic fatty liver disease in women with polycystic ovary syndrome: do androgens play a role?
  382. Progress of research on the role of active ingredients of Citri Reticulatae Pericarpium in liver injury
  383. Recent insights into the pathogenesis and therapeutic targets of chronic liver diseases
  384. Role of gp91phox in hepatic macrophage programming and alcoholic liver disease
  385. Fibroblast growth factor 21 response in a preclinical alcohol model of acute-on-chronic liver injury
  386. Adaptive effect of sericin on hepatic mitochondrial conformation through its regulation of apoptosis, autophagy and energy maintenance: a proteomics approach
  387. Functions of hepatic non-parenchymal cells in alcoholic liver disease
  388. Advances in alcoholic liver disease: An update on alcoholic hepatitis
  389. Cannabinoids and Chronic Liver Diseases
  390. Curcumin combined with Baicalin attenuated ethanol-induced hepatitis by suppressing p38 MAPK and TSC1/eIF-2α/ATF4 pathways in rats
  391. The Role of CD36 in the Pathogenesis of alcohol-Related Disease
  392. Epithelial splicing regulatory protein 2–mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis
  393. β-catenin ISGylation promotes lipid deposition and apoptosis in ethanol-stimulated liver injury models
  394. The beneficial roles of SIRT1 in drug-induced liver injury
  395. Hydroxynonenal causes hepatocyte death by disrupting lysosomal integrity in nonalcoholic steatohepatitis
  396. Nicotinamide N-methyltransferase upregulation contributes to palmitate-elicited peroxisome proliferator-activated receptor transactivation in hepatocytes
  397. The circadian clock and liver function in health and disease
  398. Consumption of a high-fat diet rapidly exacerbates the development of fatty liver disease that occurs with chronically elevated glucocorticoids
  399. A novel fibroblast growth factor 1 variant reverses nonalcoholic fatty liver disease in type 2 diabetes.
  400. Natural compounds for counteracting nonalcoholic fatty liver disease (NAFLD): advantages and limitations of the suggested candidates
  401. Inebriated Immunity: alcohol Affects Innate Immune Signaling in the Gut-Liver-Brain Axis
  402. FGF21, a liver hormone that inhibits alcohol intake in mice, increases in human circulation after acute alcohol ingestion and sustained binge drinking at …
  403. FGF21 in obesity and cancer: New insights
  404. Structure, function and metabolism of hepatic and adipose tissue lipid droplets: implications in alcoholic liver disease
  405. Dual role of antimicrobial peptide cathelicidin in alcohol-associated liver disease.
  406. Akkermansia muciniphila Ameliorates alcoholic Liver Disease in Experimental Mice by Regulating Serum Metabolism and Improving Gut Dysbiosis
  407. Chronic ethanol-mediated decrease in cAMP primes macrophages to enhanced LPS-inducible NF-κB activity and TNF expression: relevance to alcoholic liver disease
  408. Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice
  409. High alcohol-Producing Klebsiella Pneumonia is a Bacterial Culprit of Fatty Liver Disease
  410. Low-dose ethanol intake prevents high-fat diet-induced adverse cardiovascular events in mice
  411. Parkin deficiency accentuates chronic alcohol intake-induced tissue injury and autophagy defects in brain, liver and skeletal muscle
  412. The role of HIF-1α in intestinal epithelial barrier function in alcoholic liver disease.
  413. Protective effect of ALDH2 against cyclophosphamide-induced acute hepatotoxicity via attenuating oxidative stress and reactive aldehydes
  414. Increased severity of alcoholic liver injury in female rats: role of oxidative stress, endotoxin, and chemokines
  415. Adipose lipolysis is important for ethanol to induce fatty liver in the National Institute on alcohol Abuse and alcoholism murine model of chronic and binge ethanol …
  416. Class III alcohol Dehydrogenase Plays a Key Role in the Onset of alcohol-Related/-Associated Liver Disease as an S-Nitrosoglutathione Reductase in Mice
  417. Therapeutic potential of sulforaphane in liver diseases: a review
  418. Small heterodimer partner/neuronal PAS domain protein 2 axis regulates the oscillation of liver lipid metabolism
  419. Circadian Clock and Lipid Metabolism Disruption in Fatty Liver Disease
  420. Prolonged darkness reduces liver fibrosis in a mouse model of primary sclerosing cholangitis by miR-200b down-regulation
  421. Interaction of alcohol with time of eating on markers of circadian dyssynchrony and colon tissue injury
  422. MiRNAs in alcohol-Related Liver Diseases and Hepatocellular Carcinoma: A Step toward New Therapeutic Approaches?
  423. Ubiquitin pathways regulate the pathogenesis of chronic liver disease
  424. Effects of Huangjiu, Baijiu and red Wine combined with high-fat diet on glucose and lipid metabolism: aggravate or alleviate?
  425. Zinc reduces hepatic lipid deposition and activates lipophagy via Zn2+/MTF‐1/PPARα and Ca2+/CaMKKβ/AMPK pathways
  426. Zinc supplementation reduces diet-induced obesity and improves insulin sensitivity in rats
  427. PTP1B promotes macrophage activation by regulating the NF-κB pathway in alcoholic liver injury
  428. CGX, a standardized herbal syrup, inhibits colon-liver metastasis by regulating the hepatic microenvironments in a splenic injection mouse model
  429. Physiological processes underlying organ injury in alcohol abuse
  430. Loss of Hepatocyte-Specific PPARγ Expression Ameliorates Early Events of Steatohepatitis in Mice Fed the Methionine and Choline-Deficient Diet
  431. Cichoric acid from extracted Echinacea purpurea induces the proliferation and apoptosis of peripheral blood mononuclear cells from yaks
  432. Methyl ferulic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway
  433. Mitochondrial dysfunction and mitochondrion-targeted therapeutics in liver diseases
  434. Hydrogen sulfide attenuates high-fat diet-induced non-alcoholic fatty liver disease by inhibiting apoptosis and promoting autophagy via reactive oxygen species …
  435. Enzymatic responses to alcohol and tobacco nicotine-derived nitrosamine ketone exposures in long evans rat livers
  436. Targeting epigenetics and lncRNAs in liver disease: From mechanisms to therapeutics
  437. Genetics and epigenetics of aldehyde dehydrogenase (ALDH2) in alcohol related liver disease
  438. Early-phase alcoholic liver disease: an update on animal models, pathology, and pathogenesis
  439. Effects of WY-14,643 on the phosphorylation and activation of AMP-dependent protein kinase
  440. Macrophage polarization and its role in liver disease
  441. Involvement of ceramides in non-alcoholic fatty liver disease (Nafld) atherosclerosis (ats) development: Mechanisms and therapeutic targets
  442. Chronic voluntary ethanol consumption induces favorable ceramide profiles in selectively bred alcohol-preferring (P) rats
  443. Mitochondrial dysfunction and liver disease: role, relevance, and potential for therapeutic modulation
  444. hepatic steatosis and alcoholic Hepatitis
  445. Dysregulation of Nicotinamide Adenine Dinucleotide-Dependent Pathways as a Driver of alcoholic Liver Fibrosis during Aging
  446. A comprehensive review of natural products against liver fibrosis: flavonoids, quinones, lignans, phenols, and acids
  447. Establishment and bioinformatics evaluation of the ethanol combined with palmitic acid-induced mouse hepatocyte AFLD model (the Hu-Qiu Model)
  448. Farnesol-Mediated Regulation Of hepatic Lipid Metabolism In Heparg Cells
  449. 24-Norursodeoxycholic acid ameliorates experimental alcohol-related liver disease and activates hepatic PPARc
  450. Chicoric acid suppresses BAFF expression in B lymphocytes by inhibiting NF-κB activity
  451. Evidence for an effect of clozapine on the regulation of fat-cell derived factors
  452. hepatic macrophage iron aggravates experimental alcoholic steatohepatitis
  453. Breaking fat: The regulation and mechanisms of lipophagy
  454. Hepatoprotective effects of natural drugs: Current trends, scope, relevance and future perspectives
  455. IL-37d Suppresses Rheb-mTORC1 Axis Independently of TCS2 to Alleviate alcoholic Liver Disease
  456. Gut Microbiota-Related Clinical Events and Therapeutic Interventions in alcohol-Associated Liver Disease
  457. hepatic Nampt Deficiency Aggravates Dyslipidemia and Fatty Liver in High Fat Diet Fed Mice
  458. Puerarin Prevents Bisphenol S induced Lipid Accumulation by Reducing Liver Lipid Synthesis and Promoting Lipid Metabolism in C57BL/6J Mice
  459. Mechanism and therapeutic opportunities of histone modifications in chronic liver disease
  460. Aldehyde dehydrogenase-2 activation by Alda-1 decreases necrosis and fibrosis after bile duct ligation in mice
  461. The role of the gut microbiota in the pathology and prevention of liver disease
  462. Hepato-and reno-protective effects of thymoquinone, crocin, and carvacrol: A comprehensive review
  463. Host homeostatic responses to alcohol–induced cellular stress in animal models of alcoholic liver disease
  464. Metabolomics reveals that chronic restraint stress alleviates carbon tetrachloride-induced hepatic fibrosis through the INSR/PI3K/AKT/AMPK pathway
  465. The potential application of chinese medicine in liver diseases: a new opportunity
  466. alcohol inhibits T-cell glucose metabolism and hepatitis in ALDH2-deficient mice and humans: roles of acetaldehyde and glucocorticoids
  467. Health Benefits of Silybum marianum: Phytochemistry, Pharmacology, and Applications
  468. Deletion of TLR4 attenuates lipopolysaccharide-induced acute liver injury by inhibiting inflammation and apoptosis
  469. Genetic deletion of the circadian clock transcription factor BMAL1 and chronic alcohol consumption differentially alter hepatic glycogen in mice
  470. Long-term low-dose alcohol intake promotes white adipose tissue browning and reduces obesity in mice
  471. Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice
  472. Mouse models of metabolic liver injury
  473. Clinical features, disease modifiers, and natural history of alcoholic liver disease
  474. A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators
  475. Effect of silibinin on ethanol-or acetaldehyde-induced damge of mouse primary hepatocytes in vitro
  476. Modulation of biochemical responses in rats following consumption of some herbalized Nigerian alcoholic drinks
  477. Oral administration of Ulmus davidiana extract suppresses interleukin-1β expression in LPS-induced immune responses and lung injury
  478. Probiotics for the treatment of liver disease
  479. Intestinal Microbiotas and alcoholic Hepatitis: Pathogenesis and Therapeutic Value
  480. Intestinal Microbiomics and Metabolomics Insights into the Hepatoprotective Effects of Lactobacillus paracasei CCFM1222 Against the Acute Liver Injury in Mice
  481. hepatic Neuronal Nitric Oxide Synthase Impaired hepatic Insulin Sensitivity Through Activation of p38 MAPK
  482. Long-term low-dose ethanol intake improves healthspan and resists high-fat diet-induced obesity in mice
  483. Acetaminophen-induced liver injury is attenuated in transgenic fat-1 mice endogenously synthesizing long-chain n-3 fatty acids
  484. The role of aldehyde dehygrogenase 2 in liver injury caused by vinyl chloride and high-fat diet.
  485. Rapamycin attenuates liver injury caused by vinyl chloride metabolite chloroethanol and lipopolysaccharide in mice
  486. Cannabinoid receptor type 1 (CB1R) signaling regulates hepatic gluconeogenesis via induction of endoplasmic reticulum-bound transcription factor cAMP-responsive …
  487. Role of hepatic macrophages in alcoholic liver disease
  488. Chicoric acid is a potent anti-atherosclerotic ingredient by anti-oxidant action and anti-inflammation capacity
  489. Oligochitosan glycosylation of casein by TGase: Protective effect and mechanism on alcohol–induced intestinal injury in C57BL/6 mice
  490. Chronic exposure to green light aggravates high-fat diet-induced obesity and metabolic disorders in male mice
  491. The effects of resveratrol in the treatment of metabolic syndrome
  492. Host ALDH2 deficiency aggravates nonalcoholic steatohepatitis through gut-liver axis
  493. Applications of metabolomics for understanding the action of peroxisome proliferator-activated receptors (PPARs) in diabetes, obesity and cancer
  494. Chronic low-grade inflammation is involved in TLR4 knockout-induced spontaneous obesity in aged mice
  495. Pregnane X Receptor–Humanized Mice Recapitulate Gender Differences in Ethanol Metabolism but Not Hepatotoxicity
  496. Liver-specific glucocorticoid action in alcoholic liver disease
  497. Lipopolysaccharide mediates hepatic stellate cell activation by regulating autophagy and retinoic acid signaling
  498. Articles in PresS. Am J Physiol Endocrinol Metab (February 1, 2011). doi: 10.1152/ajpendo. 00387.2010
  499. Chicoric acid prevents methotrexate hepatotoxicity via attenuation of oxidative stress and inflammation and up-regulation of PPARγ and Nrf2/HO-1 signaling
  500. hepatic nNOS impaired hepatic insulin sensitivity through the activation of p38 MAPK
  501. Neurosecretory Protein GL Promotes Normotopic Fat Accumulation in Male ICR Mice
  502. Aldehyde dehydrogenase-2 as a therapeutic target
  503. Effects of Astaxanthin on Body and Liver Weight of High-Fat Diet through Regulation of Peroxisome Proliferator-Activated Receptors (PPARs)
  504. Articles in PresS. Am J Physiol Gastrointest Liver Physiol (April 26, 2012). doi: 10.1152/ajpgi. 00024.2012
  505. Luteolin-mediated inhibition of hepatic stellate cell activation via suppression of the STAT3 pathway
  506. Bile acid metabolism and circadian rhythms
  507. Functionalized 6-(piperidin-1-yl)-8, 9-diphenyl purines as peripherally restricted inverse agonists of the CB1 receptor
  508. Progress in the Correlation Between Inflammasome NLRP3 and Liver Fibrosis
  509. The Impact of Gut Microbiota on Liver Injury
  510. A Transcriptomic Response to Lactiplantibacillus plantarum-KCC48 against High-Fat Diet-induced Fatty Liver Diseases in Mice
  511. Colonic microbiome is altered in alcoholism
  512. miR-130b is a potent stimulator of hepatic very-low-density lipoprotein assembly and secretion via marked induction of microsomal triglyceride transfer protein
  513. Bakuchiol, main component of root bark of Ulmus davidiana var. japonica, inhibits TGF-β-induced in vitro EMT and in vivo metastasis
  514. Fibroblast growth factor 21 in chronic kidney disease
  515. Zebrafish Models for Liver Diseases
  516. Baicalin—Current Trends in Detection Methods and Health-Promoting Properties
  517. An Insight into the Promising Therapeutic Potential of Chicoric Acid
  518. Autophagy in health and disease. 2. Regulation of lipid metabolism and storage by autophagy: pathophysiological implications
  519. FGF21 counteracts alcohol intoxication by activating the noradrenergic nervous system
  520. 11th Annual Meeting of the Great Lakes Drug Metabolism & Disposition Group
  521. frontiers Frontiers in Physiology 2022 published: 05 July REVIEW
  522. ALDH2—the genetic polymorphism and enzymatic activity regulation: their epidemiologic and clinical implications
  523. Oroxylin A regulates cGAS DNA hypermethylation induced by methionine metabolism to promote HSC senescence
  524. Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism
  525. Role of acid sphingomyelinase in steatohepatitis
  526. Articles in PresS. Am J Physiol Endocrinol Metab (July 19, 2016). doi: 10.1152/ajpendo. 00270.2016
  527. Mincle Signaling Exacerbates Autoimmune Hepatitis
  528. ER stress and autophagy in obesity and nonalcoholic fatty liver disease
  529. Role of Ancient Ubiquitous Protein 1 in hepatic ApoB Degradation and VLDL production
  530. Neuronal modulation of hepatic lipid accumulation induced by binge-like drinking 2
  531. Mitophagy in the pathogenesis of liver diseases
  532. The hormone FGF21 stimulates water drinking in response to ketogenic diet and alcohol
  533. Liver and Biliary Tract Physiology/Pathophysiology: Genetic deletion of the circadian clock transcription factor BMAL1 and chronic alcohol consumption …
  534. GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment
  535. Roles of Small Heterodimer Partner and Retinol Binding Protein Receptor 4 Receptor Stimulated by Retinoic Acid 6-Like in hepatic Glucose and Lipid Metabolism
  536. Studies of the adduction of hepatocellular proteins by 4-HNE in animal models of alcoholic liver disease: Systematic analysis of hepatocellular Erk 1/2 modulation and …
  537. How lipid droplets “TAG” along: Glycerolipid synthetic enzymes and lipid storage
  538. Inhibition of ghrelin activity by the receptor antagonist [D-Lys3]-GHRP-6 enhances hepatic fatty acid oxidation and gluconeogenesis in a growing pig model
  539. Direct regulation of myocardial triglyceride metabolism by the cardiomyocyte circadian clock
  540. A novel comparative pattern analysis approach identifies chronic alcohol mediated dysregulation of transcriptomic dynamics during liver regeneration
  541. Fatty acid composition but not quantity is an important indicator of Non-alcoholic Fatty Liver Disease: A Systematic Review
  542. Lactobacillus paracasei CCFM1223 Protects against Lipopolysaccharide-induced Acute Liver Injury in Mice by Regulating the “Gut–Liver” Axis
  543. Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients
  544. The influence of chronic alcohol consumption on invariant natural killer T cells
  545. Oroxylin A: A promising flavonoid for prevention and treatment of chronic diseases
  546. Ghrelin ameliorates cardiac fibrosis after myocardial infarction by regulating the Nrf2/NADPH/ROS pathway
  547. Effect of ethanol on hydrogen peroxide-induced AMPK phosphorylation
  548. Mesencephalic astrocyte-derived neurotrophic factor (MANF): Structure, functions and therapeutic potential
  549. ALDH2 protects against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1 …
  550. The role of ferroptosis in organ toxicity
  551. Thymoquinone binds and activates human salivary aldehyde dehydrogenase: Potential therapy for the mitigation of aldehyde toxicity and maintenance of oral health
  552. Antrodia cinnamomea Confers Obesity Resistance and Restores Intestinal Barrier Integrity in Leptin-deficient Obese Mice
  553. Chemical constituents of the root bark of Ulmus davidiana var. japonica and their potential biological activities
  554. Blockade of glycolysis-dependent contraction by oroxylin a via inhibition of lactate dehydrogenase-a in hepatic stellate cells
  555. Electroacupuncture ameliorates peptic ulcer disease in association with gastroduodenal microbiota modulation in mice
  556. Deciphering the Underlying Mechanisms of Formula Le-Cao-Shi Against Liver Injuries by Integrating Network Pharmacology, Metabonomics, and …
  557. Gut-liver axis
  558. Current evidence on the use of probiotics in liver diseases
  559. BBA-Molecular Basis of Disease
  560. Introducing Trolox as an Antioxidant: Preclinical Safety and Efficacy Investigations on Mice
  561. Browning of the white adipose tissue regulation: New insights into nutritional and metabolic relevance in health and diseases
  562. Intestinal barrier dysfunction, LPS translocation, and disease development
  563. Methyl ferulic acid ameliorates prolonged high insulin-induced insulin release and synthesis in pancreatic β-cells via the miR-378b–PI3K–AKT pathway
  564. Liuyi Hao, Qian Sun, Wei Zhong, Wenliang
  565. Metabolomics analysis reveals the mechanisms of the effect of Sijunzi decoction on spleen deficiency syndrome in a rat model
  566. Targeting NR1D1 in organ injury: challenges and prospects
  567. Application of a dye-based mitochondrion-thermometry to determine the receptor downstream of prostaglandin E2 involved in the regulation of hepatocyte …
  568. Redox modulation of adipocyte differentiation: hypothesis of “Redox Chain” and novel insights into intervention of adipogenesis and obesity
  569. Lipid droplets in health and disease
  570. Hypoglycemic effect of polysaccharides of Dendrobium officinale compound on type 2 diabetic mice
  571. Metabolic profiling of copper-laden hepatolenticular degeneration model rats and the interventional effects of Gandou decoction using UPLC-Q-TOF/MS
  572. Site-specific ubiquitination of VDAC1 restricts its oligomerization and mitochondrial DNA release in liver fibrosis
  573. Health Benefits of Key Constituents in Cichorium intybus L.
  574. Activation of aldehyde dehydrogenase 2 slows down the progression of atherosclerosis via attenuation of ER stress and apoptosis in smooth muscle cells
  575. Mitochondrial aldehyde dehydrogenase obliterates insulin resistance-induced cardiac dysfunction through deacetylation of PGC-1α
  576. Abnormal lipid droplets accumulation induced cognitive deficits in obstructive sleep apnea syndrome mice via JNK/SREBP/ACC pathway but not through PDP1/PDC …
  577. Differential impact of cold and hot tea extracts on tyrosine phosphatases regulating insulin receptor activity: a focus on PTP1B and LMW-PTP
  578. Pros and cons of fatty acids in bone biology
  579. Betaine inhibits Toll-like receptor 4 responses and restores intestinal microbiota in acute liver failure mice
  580. Glucocorticoid receptor contributes to the altered expression of hepatic cytochrome P450 upon cigarette smoking
  581. Betaine as a Functional Ingredient: Metabolism, Health-Promoting Attributes, Food Sources, Applications and Analysis Methods
  582. Pharmacological Activities and Pharmacokinetics of Glycycoumarin
  583. Activator of mitochondrial aldehyde dehydrogenase (Alda-1) could enhance quality of equine cooled semen by ameliorating loss of mitochondrial function over time
  584. A Review on Pharmacological and Therapeutic Properties of Echinacea
  585. The anti-diabetic potential of betaine. Mechanisms of action in rodent models of type 2 diabetes
  586. Regulation of hepatic ER stress by the E3 ubiquitin ligase gp78 in zebrafish
  587. Inhibition of PPARγ Gene Particle Downregulates the Differentiation of Rabbit Bone Marrow Mesenchymal Stem Cells into Adipocytes
  588. Inhibition of miR-155 potentially protects against lipopolysaccharide-induced acute lung injury through the IRF2BP2-NFAT1 pathway
  589. Integrative Analysis of Transcriptomic and Metabolomic Data for Identification of Pathways Related to Matrine-induced Hepatotoxicity
  590. Phosphodiesterase-4B as a therapeutic target for cognitive impairment and obesity-related metabolic diseases
  591. AMPK activation enhances the anti-atherogenic effects of high density lipoproteins in apoE−/− mice
  592. Obesity and Hepatocellular Carcinoma: Epidemiology and Mechanisms
  593. FGF21 Depletion Attenuates Colitis through Intestinal Epithelial IL-22-STAT3 Activation in Mice
  594. Protection of retinal function and morphology in MNU-induced retinitis pigmentosa rats by ALDH2: an in-vivo study
  595. Cichoric Acid May Play a Role in Protecting Hair Cells from Ototoxic Drugs
  596. Chicoric acid attenuates hyperglycemia-induced endothelial dysfunction through AMPK-dependent inhibition of oxidative/nitrative stresses
  597. Potential Anti-Skin Aging Effect of (-)-Catechin Isolated from the Root Bark of Ulmus davidiana var. japonica in Tumor Necrosis Factor-α-Stimulated Normal Human …
  598. Inhibition of miR-155 potentially protects
  599. Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism.
  600. Effect of fibroblast growth factor 21 on hepatic fibrosis in mice and its mechanism
  601. Identification of a Novel Heart–Liver Axis: Matrix Metalloproteinase‐2 Negatively Regulates Cardiac Secreted Phospholipase A2 to Modulate Lipid Metabolism and …
  602. Metabolic messengers: endocannabinoids
  603. Possible Mechanisms of Dark Tea in Cancer Prevention and Management: A Comprehensive Review
  604. Metabolic Regulation by Lipid Activated Receptors
  605. FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit
  606. Intervention effect of qi-Yu-San-Long decoction on Lewis lung carcinoma in C57bl/6 mice: Insights from uplc–Qtof/Ms-Based metabolic profiling
  607. Secretomics to discover regulators in diseases
  608. The intestinal microbiota as a therapeutic target in the treatment of NAFLD and ALD
  609. The Ameliorative Potential of Alda-1 on Experimentally induced Liver Fibrosis in Adult Male Mice. A Histological, Immunohistochemical and Biochemical Study
  610. Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers …
  611. Ghrelin regulates mitochondrial-lipid metabolism gene expression and tissue fat distribution in liver and skeletal muscle
  612. Increased liver carnitine content in obese women
  613. Bta-miR-34b regulates milk fat biosynthesis by targeting mRNA decapping enzyme 1A (DCP1A) in cultured bovine mammary epithelial cells
  614. Targeting hepatic serine-arginine protein kinase 2 ameliorates alcohol-associated liver disease by alternative splicing control of lipogenesis
  615. Protective effect of alkaline phosphatase supplementation on infant health
  616. Protective Effect of Baicalin on Chlorpyrifos-induced Liver Injury and Its Mechanism
  617. Diurnal oscillations of endogenous H2O2 sustained by p66Shc regulate circadian clocks
  618. Iron overload reduces synthesis and elimination of bile acids in rat liver
  619. Fish oil, but not olive oil, ameliorates depressive-like behavior and gut microbiota dysbiosis in rats under chronic mild stress
  620. CD74 ablation rescues type 2 diabetes mellitus-induced cardiac remodeling and contractile dysfunction through pyroptosis-evoked regulation of ferroptosis
  621. Dual Effects of ALDH2 rs671 on Biochemical Indicators in Chinese Males
  622. Modulation of diverse oncogenic signaling pathways by oroxylin A: An important strategy for both cancer prevention and treatment
  623. Regulation of glucose homeostasis by FGF21
  624. Nicotinamide Adenine Dinucleotide (NAD+) and Enkephalinase Inhibition (IV1114589NAD) Infusions Significantly Attenuate Psychiatric Burden Sequalae in …
  625. FGF21 protects the blood–brain barrier by upregulating PPARγ via FGFR1/β-klotho after traumatic brain injury
  626. Possible mechanisms of the prevention of doxorubicin toxicity by cichoric acid—antioxidant nutrient
  627. Circadian regulation of low density lipoprotein receptor promoter activity by CLOCK/BMAL1, Hes1 and Hes6
  628. Effects of dietary pyruvate and exercise training on body composition and insulin resistance of obese Zucker rats
  629. The role of ALDH2 in sepsis and the to-be-discovered mechanisms
  630. Comparative effectiveness of glycyrrhizic acid preparations aimed at improving liver function of patients with chronic hepatitis B: A network meta-analysis of 53 …
  631. Ethanol (EtOH)-Mediated Differentiation of Embryonic Stem Cells via Retinoic Acid (RA)-Retinoic Acid Receptor-Gamma (RARγ) Signaling
  632. Fisetin: A senolytic drug
  633. Quantification of common and planar bile acids in tissues and cultured cells
  634. Regulation of Glucose Homeostasis by FGF21
  635. TMT-based quantitative proteomics reveals the targets of andrographolide on LPS-induced liver injury
  636. Comprehensive metabolomic analysis reveals dynamic metabolic reprogramming in Hep3B cells with aflatoxin B1 exposure
  637. A NOVEL FLUORESCENT HPLC-BASED METABOLIC LABELING TECHNIQUE REVEALS EFFECTS OF NUTRITIONAL CONTEXT ON DIETARY FATTY ACID …
  638. The bioactive effects of chicoric acid as a functional food ingredient
  639. Mechanisms of carnitine-mediated modulation of aflatoxin B (1)-DNA adduct formation
  640. Chicoric acid ameliorates sepsis-induced cardiomyopathy via regulating macrophage metabolism reprogramming
  641. The inhibition of microRNA-203 on ischemic reperfusion injury after total knee arthroplasty via suppressing MYD88-mdiated toll-like receptor signaling pathway
  642. MicroRNA-212 targets SIRT2 to influence lipogenesis in bovine mammary epithelial cell line
  643. A phenomics-based approach for the detection and interpretation of shared genetic influences on 29 biochemical indices in southern Chinese men
  644. Age-related NAD+ decline
  645. Lpin1/2, Dgat2, and Pnpla2/3), and lipid droplet (Plin2/5, Lipe, Mgll, and Abdh5) genes, along with protein abundances of p-ACC, MCD, and FASN. Lipidomics …
  646. PPARγ-mediated insulin sensitization: the importance of fat versus muscle
  647. TMT-Based Quantitative Proteomics Reveals the Targets of Andrographolide on LPS-induced Liver Injury
  648. The role and possible mechanism of lncRNA U90926 in modulating 3T3-L1 preadipocyte differentiation
  649. MicroRNAs as systemic biomarkers to assess distress in animal models for gastrointestinal diseases
  650. Amaranth’s 2-caffeoylisocitric acid—An anti-inflammatory caffeic acid derivative that impairs NF-κB signaling in LPS-challenged RAW 264.7 macrophages
  651. TRP channels as sensors of aldehyde and oxidative stress
  652. Possible Mechanisms of the Prevention of Doxorubicin Toxicity by Cichoric Acid—Antioxidant Nutrient
  653. The effect of fibroblast growth factor 21 on a mouse model of bovine viral diarrhea
  654. Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers
  655. Targeting ALDH2 in atherosclerosis: molecular mechanisms and therapeutic opportunities
  656. Long noncoding RNA ACART knockdown decreases 3T3-L1 preadipocyte proliferation and differentiation
  657. GPR120 suppresses adipose tissue lipolysis and synergizes with GPR40 in antidiabetic efficacy
  658. UVB-induced microvesicle particle release and its effects on the cutaneous microenvironment
  659. Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload
  660. Probiotics increase intramuscular fat and improve the composition of fatty acids in Sunit sheep through the adenosine 5′-monophosphate-activated protein …
  661. n–3 PUFAs Reduce T-Helper 17 Cell Differentiation by Decreasing Responsiveness to Interleukin-6 in Isolated Mouse Splenic CD4+ T Cells
  662. Aldehyde dehydrogenase 2 (ALDH2) and aging: is there a sensible link?
  663. MiR-203 regulates estrogen receptor α and cartilage degradation in IL-1β-stimulated chondrocytes
  664. The use of chicoric acid from Echinacea purpurea as a feed additive in poultry nutrition
  665. Lactobacillus plantarum ZJUIDS04 alleviates DSS-induced colitis via modulating gut microbiota
  666. Untargeted metabolomics profiles delineate metabolic alterations in mouse plasma during lung carcinoma development using UPLC-QTOF/MS in MSE mode
  667. PGC-1α: a key regulator of energy metabolism
  668. miR-378 affects metabolic disturbances in the mdx model of Duchenne muscular dystrophy
  669. Structural elucidation of 3-nitrophenylhydrazine derivatives of tricarboxylic acid cycle acids and optimization of their fragmentation to boost sensitivity in liquid …
  670. Study on the anti-mitochondrial apoptosis mechanism of Erigeron breviscapus injection based on UPLC-Q-TOF-MS metabolomics and molecular docking in …
  671. Enhancement in the catalytic activity of human salivary aldehyde dehydrogenase by alliin from garlic: implications in aldehyde toxicity and oral health
  672. Role of fibroblast growth factor 21 in obesity-induced hypothalamic inflammation
  673. HIF-1α is a potential molecular target for herbal medicine to treat diseases
  674. Combination of starvation interval and food volume determines the phase of liver circadian rhythm in Per2::Luc knock-in mice under two meals per day feeding
  675. Macrophage migration inhibitory factor deficiency augments doxorubicin‐induced cardiomyopathy
  676. A preliminary study on the possibility of fermented pineapple peel residue partially replacing whole corn silage in feeding Chuanzhong black goats
  677. Exercise-induced extracellular vesicles delay the progression of prostate cancer
  678. Effects of n-3 polyunsaturated fatty acids on chemical-induced liver injury in mice
  679. Human Amniotic Mesenchymal Stem Cells Alleviate aGVHD after allo-HSCT by Regulating Interactions between Gut Microbiota and Intestinal Immunity
  680. Bile Acids as Biomarkers and Evolutionary Phenotypes
  681. Liver scaffolds obtained by decellularization: A transplant perspective in liver bioengineering
  682. Obtaining Cell Cultures of Medicinal Plants
  683. Psychobiotic potential of Lactiplantibacillus plantarum: Current perspective in neurodegeneration and geriatric therapies
  684. Stress decreases spermatozoa quality and induces molecular alterations in zebrafish progeny
  685. Stress decreases spermatozoa quality and induces molecular alterations in zebrafish progeny
  686. Enzyme immobilization strategies and bioprocessing applications
  687. Metabolomic Profiling of Lungs from Mice Reveals the Variability of Metabolites in Pneumocystis Infection and the Metabolic Abnormalities in BAFF-R-Deficient Mice
  688. Mutations of DEPDC5 cause autosomal dominant focal epilepsies
  689. Knockout of the epilepsy gene Depdc5 in mice causes severe embryonic dysmorphology with hyperactivity of mTORC1 signalling
  690. Mutations in DEPDC5 cause familial focal epilepsy with variable foci
  691. alcohol: the role in nutrition and health
  692. Long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 correlates with microRNA-125b/microRNA-146a/microRNA-203 and predicts 2-year …
  693. Improvement of inflammatory bowel disease by lactic acid bacteria-derived metabolites: a review
  694. BIGKnock: fine-mapping gene-based associations via knockoff analysis of biobank-scale data
  695. Fine-mapping gene-based associations via knockoff analysis of biobank-scale data with applications to UK Biobank
  696. Parallel metabolomic profiling of cerebrospinal fluid, plasma, and spinal cord to identify biomarkers for spinal cord injury
  697. Neuregulin-1β promotes glucose uptake via PI3K/Akt in neonatal rat cardiomyocytes
  698. High-resolution in situ hybridization to whole-mount zebrafish embryos
  699. frontiers MINI REVIEW in Immunology published: 30 March 2022 doi: 10.3389/fimmu. 2022.876515
  700. Growth factors-based therapeutic strategies and their underlying signaling mechanisms for peripheral nerve regeneration
  701. Pharmacological correction of long QT-linked mutations in KCNH2 (hERG) increases the trafficking of Kv11.1 channels stored in the transitional endoplasmic …
  702. Unknown Etiology of Liver Abscess
  703. Advances in biological functions and clinical studies of FGF21
  704. Activity pattern, budget and diurnal rhythmicity of the brown-throated three-toed sloth (Bradypus variegatus) in northeastern Brazil
  705. and Hanxiao Ge () Air Force Medical Center of AFMU, Beijing 100142, China gehanxiao@ foxmail. com
  706. Advances in the mechanism of action of silent information regulator 1 in alcoholic liver disease and related pharmaceutical studies
  707. Current status and perspectives of fibroblast growth factor 21 in nonalcoholic fatty liver disease
  708. Ascites, Renal Dysfunction, and Hepatorenal Syndrome
  709. Features of lipidomic profile of erythrocyte membranes and blood serum in patients with fatty liver disease
  710. Association of hypoxic microenvironment with the development and progression of liver diseases
  711. Sleep Duration and the Gut Microbiota in Infancy: an exploration of the determinants of sleep and the association between sleep and the gut microbiota at 3 months of …
  712. The insulin receptor: structure, function, and signaling
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