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(Nrf2) (Activator | Activators | Activation)

  1. Molecular mechanism of nrf2 activation by oxidative stress
  2. The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress
  3. Natural Nrf2 activators in diabetes
  4. Nrf2 activation as target to implement therapeutic treatments
  5. Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation
  6. Mechanism of chemical activation of Nrf2
  7. Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy
  8. Nrf2 activators as attractive therapeutics for diabetic nephropathy
  9. Effect of redox modulating NRF2 activators on chronic kidney disease
  10. Combating oxidative stress in diabetic complications with Nrf2 activators: how much is too much?
  11. CUL3 and NRF2 Mutations Confer an NRF2 Activation Phenotype in a Sporadic Form of Papillary Renal Cell Carcinoma
  12. The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress
  13. Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators
  14. Effect of Nrf2 activators on release of glutathione, cysteinylglycine and homocysteine by human U373 astroglial cells
  15. Nrf2 signaling in coordinated activation of antioxidant gene expression
  16. Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia–reperfusion injury
  17. Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2
  18. Acute oxidative stress and systemic Nrf2 activation by the ketogenic diet
  19. Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
  20. Nrf2 activation: a potential strategy for the prevention of acute mountain sickness
  21. Development of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators
  22. NRF2 activation is involved in ozonated human serum upregulation of HO-1 in endothelial cells
  23. Sulforaphane protects against cardiovascular disease via Nrf2 activation
  24. Nrf2 activation prevents cadmium-induced acute liver injury
  25. Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation
  26. The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer
  27. Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis
  28. Nrf2 activation protects the liver from ischemia/reperfusion injury in mice
  29. Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells
  30. Keap1‐Nrf2 activation in the presence and absence of DJ‐1
  31. Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer
  32. Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis–related fibrosis in a dietary rat model
  33. miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells
  34. Role of impaired Nrf2 activation in the pathogenesis of oxidative stress and inflammation in chronic tubulo-interstitial nephropathy
  35. Nrf2 activation protects against solar-simulated ultraviolet radiation in mice and humans
  36. Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: involvement of hydrogen peroxide
  37. A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62
  38. Effect of graded Nrf2 activation on phase-I and-II drug metabolizing enzymes and transporters in mouse liver
  39. Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation
  40. Abbott boosts investment in NRF2 activators for reducing oxidative stress
  41. Involvement of Nrf2 activation in resistance to 5-fluorouracil in human colon cancer HT-29 cells
  42. Activation of hepatic Nrf2 in vivo by acetaminophen in CD‐1 mice
  43. Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress
  44. Identification of ketoconazole as an AhR-Nrf2 activator in cultured human keratinocytes: the basis of its anti-inflammatory effect
  45. Activation of the Nrf2–ARE signaling pathway: a promising strategy in cancer prevention
  46. Hepatitis B virus stimulates G6PD expression through HBx-mediated Nrf2 activation
  47. Tert-butylhydroquinone induces mitochondrial oxidative stress causing Nrf2 activation
  48. Transcriptional regulation of the antioxidant response element: activation by Nrf2 and repression by MafK
  49. Dietary ellagic acid improves oxidant-induced endothelial dysfunction and atherosclerosis: role of Nrf2 activation
  50. … -mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates—Nrf2 activators and GSK-3 …
  51. The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation
  52. The Nrf2 activator tBHQ inhibits T cell activation of primary human CD4 T cells
  53. Redox activation of Nrf2 & NF-κB: a double end sword?
  54. Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify …
  55. Activation of the Nrf2/antioxidant response pathway increases IL‐8 expression
  56. Adaptive response to GSH depletion and resistance to l-buthionine-(S,R)-sulfoximine: involvement of Nrf2 activation
  57. NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer
  58. Review of molecular mechanisms involved in the activation of the Nrf2-ARE signaling pathway by chemopreventive agents
  59. Th2 skewing by activation of Nrf2 in CD4+ T cells
  60. Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes
  61. Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells
  62. Anti-Atherogenic Effect of Laminar Shear Stress via Nrf2 Activation
  63. T lymphocyte–specific activation of Nrf2 protects from AKI
  64. Skin resistance to oxidative stress induced by resveratrol: from Nrf2 activation to GSH biosynthesis
  65. Protocatechuic acid induces antioxidant/detoxifying enzyme expression through JNK-mediated Nrf2 activation in murine macrophages
  66. Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state
  67. Identification of Chromomoric Acid CI as an Nrf2 Activator in Chromolaena odorata
  68. Extracellular redox status regulates Nrf2 activation through mitochondrial reactive oxygen species
  69. … protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element: degradation of Nrf2 by the 26 S …
  70. Nrf2 activation is associated with Z-DNA formation in the human HO-1 promoter
  71. Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR‐dependent motor neuron apoptosis
  72. Nrf2 activators provide neuroprotection against 6‐hydroxydopamine toxicity in rat organotypic nigrostriatal cocultures
  73. Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation
  74. Antioxidant and anti-inflammatory activities of a natural compound, shizukahenriol, through Nrf2 activation
  75. Nrf2 activation involves an oxidative-stress independent pathway in tetrafluoroethylcysteine-induced cytotoxicity
  76. Reporter protein complementation imaging assay to screen and study Nrf2 activators in cells and living animals
  77. Caffeic acid phenethyl ester-mediated Nrf2 activation and IκB kinase inhibition are involved in NFκB inhibitory effect: structural analysis for NFκB inhibition
  78. The Nrf2 activator oltipraz also activates the constitutive androstane receptor
  79. Tyrosine phosphorylation controls nuclear export of Fyn, allowing Nrf2 activation of cytoprotective gene expression
  80. Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H‐1, 2‐dithiole‐3‐thione
  81. Hydroxytyrosol induces proliferation and cytoprotection against oxidative injury in vascular endothelial cells: role of Nrf2 activation and HO-1 induction
  82. Anti-H1N1 virus, cytotoxic and Nrf2 activation activities of chemical constituents from Scutellaria baicalensis
  83. TNF mediates the sustained activation of Nrf2 in human monocytes
  84. KEAP1 gene mutations and NRF2 activation are common in pulmonary papillary adenocarcinoma
  85. Dimethyl Fumarate and Monoethyl Fumarate Exhibit Differential Effects on KEAP1, NRF2 Activation, and Glutathione Depletion In Vitro
  86. Simvastatin lowers reactive oxygen species level by Nrf2 activation via PI3K/Akt pathway
  87. BMP-driven NRF2 activation in esophageal basal cell differentiation and eosinophilic esophagitis
  88. Discovery and modification of in vivo active Nrf2 activators with 1, 2, 4-oxadiazole core: hits identification and structure–activity relationship study
  89. Nrf2 activators modulate oxidative stress responses and bioenergetic profiles of human retinal epithelial cells cultured in normal or high glucose conditions
  90. Nrf2 activation attenuates both orthodontic tooth movement and relapse
  91. Arsenic‐mediated activation of the Nrf2‐Keap1 antioxidant pathway
  92. Nutritional strategies to modulate inflammation and oxidative stress pathways via activation of the master antioxidant switch Nrf2
  93. Transcription factor Nrf2 activation by deltamethrin in PC12 cells: involvement of ROS
  94. Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway
  95. Inhibition of liver fibrosis by solubilized coenzyme Q10: role of Nrf2 activation in inhibiting transforming growth factor-β1 expression
  96. NRF2 activation restores disease related metabolic deficiencies in olfactory neurosphere-derived cells from patients with sporadic Parkinson’s disease
  97. Potential role for Nrf2 activation in the therapeutic effect of MG132 on diabetic nephropathy in OVE26 diabetic mice
  98. Nrf2 activation by sulforaphane restores the age-related decrease of TH1 immunity: Role of dendritic cells
  99. Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of NLRP3 inflammasome and enhancing Nrf2 activation
  100. Is ozone pre-conditioning effect linked to Nrf2/EpRE activation pathway in vivo? A preliminary result
  101. The antioxidant function of sestrins is mediated by promotion of autophagic degradation of Keap1 and Nrf2 activation and by inhibition of mTORC1
  102. Ebselen attenuates cisplatin-induced ROS generation through Nrf2 activation in auditory cells
  103. A protective mechanism of licorice (Glycyrrhiza uralensis): isoliquiritigenin stimulates detoxification system via Nrf2 activation
  104. PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress
  105. Activation of Nrf2 in defense against cadmium-induced oxidative stress
  106. Activation of Nrf2/ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression
  107. MicroRNA-200a controls Nrf2 activation by target Keap1 in hepatic stellate cell proliferation and fibrosis
  108. Activation of transcription factor Nrf2 by hepatitis C virus induces the cell-survival pathway
  109. Nrf2 activation supports cell survival during hypoxia and hypoxia/reoxygenation in cardiomyoblasts; the roles of reactive oxygen and nitrogen species
  110. Activation of Nrf2-antioxidant signaling attenuates NFκB-inflammatory response and elicits apoptosis
  111. Activation of Nrf2–ARE pathway in brain after traumatic brain injury
  112. The chalcone compound isosalipurposide (ISPP) exerts a cytoprotective effect against oxidative injury via Nrf2 activation
  113. Endothelial Nrf2 activation: a new target for resveratrol?
  114. Dissection of the role of p62/Sqstm1 in activation of Nrf2 during xenophagy
  115. Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2
  116. EGFR mediates astragaloside IV-induced Nrf2 activation to protect cortical neurons against in vitro ischemia/reperfusion damages
  117. … to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response …
  118. Keap1 mutations and Nrf2 pathway activation in epithelial ovarian cancer
  119. Reoxygenation‐specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia‐reperfusion injury
  120. Activation of Nrf2 protects against triptolide-induced hepatotoxicity
  121. New insights into the pathogenesis of preeclampsia–the role of nrf2 activators and their potential therapeutic impact
  122. Activation of Nrf2 in keratinocytes causes chloracne (MADISH)‐like skin disease in mice
  123. Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1–Cul3 interaction
  124. Role of Nrf2 activation and NF-κB inhibition in valproic acid induced hepatotoxicity and in diammonium glycyrrhizinate induced protection in mice
  125. ERK and PI3K signaling cascades induce Nrf2 activation and regulate cell viability partly through Nrf2 in human glioblastoma cells
  126. Translational control of nrf2 protein in activation of antioxidant response by oxidants
  127. Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia
  128. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
  129. Lutein suppresses inflammatory responses through Nrf2 activation and NF‐κB inactivation in lipopolysaccharide‐stimulated BV‐2 microglia
  130. Nrf2 activation promotes keratinocyte survival during early skin carcinogenesis via metabolic alterations
  131. Photothrombosis-induced infarction of the mouse cerebral cortex is not affected by the Nrf2-activator sulforaphane
  132. Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophillic phase II inducers
  133. Screening of natural compounds as activators of the keap1-nrf2 pathway
  134. LKB1 Loss induces characteristic patterns of gene expression in human tumors associated with NRF2 activation and attenuation of PI3K-AKT
  135. Prevention of diabetic complications by activation of Nrf2: diabetic cardiomyopathy and nephropathy
  136. KLF2 primes the antioxidant transcription factor Nrf2 for activation in endothelial cells
  137. tert-Butylhydroquinone (tBHQ) protects hepatocytes against lipotoxicity via inducing autophagy independently of Nrf2 activation
  138. Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover
  139. Hydrogen Sulfide Protects Against Cellular Senescence via S-Sulfhydration of Keap1 and Activation of Nrf2
  140. Enhanced hepatic Nrf2 activation after ursodeoxycholic acid treatment in patients with primary biliary cirrhosis
  141. Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway
  142. Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes
  143. The Nrf2 activator, tBHQ, differentially affects early events following stimulation of Jurkat cells
  144. AICAR induces Nrf2 activation by an AMPK-independent mechanism in hepatocarcinoma cells
  145. Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice
  146. Design, synthesis and evaluation of novel PEGylated curcumin analogs as potent Nrf2 activators in human bronchial epithelial cells
  147. Nrf2 activation in astrocytes contributes to spinal cord ischemic tolerance induced by hyperbaric oxygen preconditioning
  148. Acquisition of doxorubicin resistance in ovarian carcinoma cells accompanies activation of the NRF2 pathway
  149. Activation of coupled Ah receptor and Nrf2 gene batteries by dietary phytochemicals in relation to chemoprevention
  150. Activation of Nrf2 and accumulation of ubiquitinated A170 by arsenic in osteoblasts
  151. Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formation
  152. Chemical and biological mechanisms of phytochemical activation of Nrf2 and importance in disease prevention
  153. NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation
  154. Sulforaphane and α-Lipoic Acid Upregulate the Expression of the π Class of Glutathione S-Transferase through c-Jun and Nrf2 Activation
  155. Activation of Nrf2 by H2O2: de novo synthesis versus nuclear translocation
  156. Activated Nrf2 impairs liver regeneration in mice by activation of genes involved in cell‐cycle control and apoptosis
  157. Activation of Nrf2-mediated oxidative stress response in macrophages by hypochlorous acid
  158. Dietary Nrf2 activators inhibit atherogenic processes
  159. Bilirubin mediated oxidative stress involves antioxidant response activation via Nrf2 pathway
  160. Upregulation of phase II enzymes through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress
  161. Thyroid Hormone Administration Induces Rat Liver Nrf2 Activation: Suppression by N-Acetylcysteine Pretreatment
  162. Characterization of Nrf2 activation and heme oxygenase-1 expression in NIH3T3 cells exposed to aqueous extracts of cigarette smoke
  163. The effect of Nrf2 pathway activation on human pancreatic islet cells
  164. Prevention of diabetic nephropathy by sulforaphane: possible role of Nrf2 upregulation and activation
  165. Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para-and ortho-hydroquinones
  166. Age-Associated Vascular Oxidative Stress, Nrf2 Dysfunction, and NF-κB Activation in the Nonhuman Primate Macaca mulatta
  167. Salvianolic acid A protects RPE cells against oxidative stress through activation of Nrf2/HO-1 signaling
  168. Genetic activation of Nrf2 protects against fasting-induced oxidative stress in livers of mice
  169. Activation of Nrf2-regulated glutathione pathway genes by ischemic preconditioning
  170. … of a stable antioxidant response element–driven reporter gene cell line and its use to show redox-dependent activation of Nrf2 by cancer chemotherapeutic agents
  171. Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism
  172. Hepatitis B virus induces expression of antioxidant response element-regulated genes by activation of Nrf2
  173. Nuclear heme oxygenase-1 (HO-1) modulates subcellular distribution and activation of Nrf2, impacting metabolic and anti-oxidant defenses
  174. NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1α
  175. Hsp90 interaction with INrf2 (Keap1) mediates stress-induced Nrf2 activation
  176. Lithium protects against paraquat neurotoxicity by NRF2 activation and miR-34a inhibition in SH-SY5Y cells
  177. A novel natural Nrf2 activator with PPARγ-agonist (monascin) attenuates the toxicity of methylglyoxal and hyperglycemia
  178. Antioxidant effects of Lactobacillus plantarum via activation of transcription factor Nrf2
  179. Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha
  180. Resveratrol dimers, nutritional components in grape wine, are selective ROS scavengers and weak Nrf2 activators
  181. Nrf2 is essential for cholesterol crystal‐induced inflammasome activation and exacerbation of atherosclerosis
  182. Protection against phalloidin-induced liver injury by oleanolic acid involves Nrf2 activation and suppression of Oatp1b2
  183. Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates …
  184. Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress
  185. Dieckol enhances the expression of antioxidant and detoxifying enzymes by the activation of Nrf2–MAPK signalling pathway in HepG2 cells
  186. Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells
  187. Bioactive food components prevent carcinogenic stress via Nrf2 activation in BRCA1 deficient breast epithelial cells
  188. NRF2 pathway activation and adjuvant chemotherapy benefit in lung squamous cell carcinoma
  189. Temozolomide and irradiation combined treatment-induced Nrf2 activation increases chemoradiation sensitivity in human glioblastoma cells
  190. Intracellular accumulation of subviral HBsAg particles and diminished Nrf2 activation in HBV genotype G expressing cells lead to an increased ROI level
  191. Vitamin A supplementation alleviates extrahepatic cholestasis liver injury through Nrf2 activation
  192. Activation of the NRF2 pathway and its impact on the prognosis of anaplastic glioma patients
  193. Nrf2 induces cisplatin resistance through activation of autophagy in ovarian carcinoma
  194. … of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2
  195. Estrogen increases Nrf2 activity through activation of the PI3K pathway in MCF-7 breast cancer cells
  196. Activation of Nrf2 by dimethyl fumarate improves vascular calcification
  197. Participation of covalent modification of Keap1 in the activation of Nrf2 by tert-butylbenzoquinone, an electrophilic metabolite of butylated hydroxyanisole
  198. Nrf2/ARE pathway activation, HO-1 and NQO1 induction by polychlorinated biphenyl quinone is associated with reactive oxygen species and PI3K/AKT signaling
  199. Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity
  200. Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation
  201. Activation of Nrf2-ARE signal pathway protects the brain from damage induced by epileptic seizure
  202. Phytochemical activation of Nrf2 protects human coronary artery endothelial cells against an oxidative challenge
  203. Glycycoumarin ameliorates alcohol-induced hepatotoxicity via activation of Nrf2 and autophagy
  204. Bakuchiol is a phenolic isoprenoid with novel enantiomer-selective anti-influenza A virus activity involving Nrf2 activation
  205. Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells
  206. Involvement of Nrf2 and JNK1 in the activation of antioxidant responsive element (ARE) by chemopreventive agent phenethyl isothiocyanate (PEITC)
  207. Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1
  208. Neohesperidin Dihydrochalcone versus CCl4-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation
  209. Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis
  210. Activation of Nrf2 by cadmium and its role in protection against cadmium-induced apoptosis in rat kidney cells
  211. … subfamily kinases regulate nuclear export and degradation of transcription factor Nrf2 to switch off Nrf2-mediated antioxidant activation of cytoprotective gene …
  212. Pharmacodynamics of ginsenosides: antioxidant activities, activation of Nrf2, and potential synergistic effects of combinations
  213. The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis
  214. Geraniol attenuates oxidative stress by Nrf2 activation in diet-induced experimental atherosclerosis
  215. Activation of NRF2 by p62 and proteasome reduction in sphere-forming breast carcinoma cells
  216. Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury
  217. Nitric oxide activation of Keap1/Nrf2 signaling in human colon carcinoma cells
  218. (−)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells
  219. … of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR‐32 …
  220. Hemin-induced activation of the thioredoxin gene by Nrf2: a differential regulation of the antioxidant responsive element by a switch of its binding factors
  221. Activation of Nrf2 by microcystin-LR provides advantages for liver cancer cell growth
  222. Systemic administration of the apocarotenoid bixin protects skin against solar UV-induced damage through activation of NRF2
  223. Identification and characterization of PERK activators by phenotypic screening and their effects on NRF2 activation
  224. Sulforaphane, an activator of Nrf2, suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes
  225. Chemopreventive role of anthocyanins in atherosclerosis via activation of Nrf2–ARE as an indicator and modulator of redox
  226. Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson’s disease
  227. Activation of endothelial nitric oxide synthase by dietary isoflavones: role of NO in Nrf2-mediated antioxidant gene expression
  228. Silica nanoparticles induce oxidative stress, inflammation, and endothelial dysfunction in vitro via activation of the MAPK/Nrf2 pathway and nuclear factor-κB signaling
  229. Cancer cell growth is differentially affected by constitutive activation of NRF2 by KEAP1 deletion and pharmacological activation of NRF2 by the synthetic …
  230. … , a novel naturally occurring ARE activator, induces the Nrf2/HO-1 axis and protects against oxidative stress-induced cell injury via activation of PI3K/AKT signaling
  231. Effects of different exercise durations on Keap1-Nrf2-ARE pathway activation in mouse skeletal muscle
  232. Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: activation by oxidatively modified LDL and 4-hydroxynonenal
  233. The Nrf2 triterpenoid activator, CDDO-imidazolide, protects kidneys from ischemia–reperfusion injury in mice
  234. Activation of the Nrf2-regulated antioxidant cell response inhibits HEMA-induced oxidative stress and supports cell viability
  235. Nrf2 negatively regulates osteoblast differentiation via interfering with Runx2-dependent transcriptional activation
  236. Stimulation of GSH synthesis to prevent oxidative stress-induced apoptosis by hydroxytyrosol in human retinal pigment epithelial cells: activation of Nrf2 and JNK-p62 …
  237. Resveratrol protects primary rat hepatocytes against oxidative stress damage:: Activation of the Nrf2 transcription factor and augmented activities of antioxidant …
  238. Activation of the Nrf2/HO-1 antioxidant pathway contributes to the protective effects of Lycium barbarum polysaccharides in the rodent retina after ischemia …
  239. Imine resveratrol analogues: molecular design, Nrf2 activation and SAR analysis
  240. Antiarrhythmic effect of lithium in rats after myocardial infarction by activation of Nrf2/HO-1 signaling
  241. The activation of the Nrf2/ARE pathway in HepG2 hepatoma cells by phytochemicals and subsequent modulation of phase II and antioxidant enzyme expression
  242. Impaired activation of the Nrf2-ARE signaling pathway undermines H2O2-induced oxidative stress response: a possible mechanism for melanocyte …
  243. Propofol induces proliferation and invasion of gallbladder cancer cells through activation of Nrf2
  244. Nrf2 activation diminishes during adipocyte differentiation of ST2 cells
  245. Long term effect of curcumin in restoration of tumour suppressor p53 and phase-II antioxidant enzymes via activation of Nrf2 signalling and modulation of …
  246. Estrogen Receptor and PI3K/Akt Signaling Pathway Involvement in S-(-)Equol-Induced Activation of Nrf2/ARE in Endothelial Cells
  247. Ethyl pyruvate-mediated Nrf2 activation and hemeoxygenase 1 induction in astrocytes confer protective effects via autocrine and paracrine mechanisms
  248. Constitutive activation of the Nrf2/Keap1 pathway in insecticide-resistant strains of Drosophila
  249. Antioxidant effects of diallyl trisulfide on high glucose-induced apoptosis are mediated by the PI3K/Akt-dependent activation of Nrf2 in cardiomyocytes
  250. Naringenin attenuates CCl4‐induced hepatic inflammation by the activation of an Nrf2‐mediated pathway in rats
  251. Erk activation is required for Nrf2 nuclear localization during pyrrolidine dithiocarbamate induction of glutamate cysteine ligase modulatory gene expression in HepG2 …
  252. Low concentration of 4-hydroxy hexenal increases heme oxygenase-1 expression through activation of Nrf2 and antioxidative activity in vascular endothelial cells
  253. Knockdown of Nrf2 suppresses glioblastoma angiogenesis by inhibiting hypoxia‐induced activation of HIF‐1α
  254. Induction of antioxidant and detoxification response by oxidants in cardiomyocytes: evidence from gene expression profiling and activation of Nrf2 transcription factor
  255. Kaposi’s sarcoma-associated herpesvirus induces Nrf2 activation in latently infected endothelial cells through SQSTM1 phosphorylation and interaction with …
  256. Laminar flow activation of ERK5 protein in vascular endothelium leads to atheroprotective effect via NF-E2-related factor 2 (Nrf2) activation
  257. Indoxyl sulfate, a uremic toxin, downregulates renal expression of Nrf2 through activation of NF-κB
  258. Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate …
  259. PI3K/Akt pathway mediates Nrf2/ARE activation in human L02 hepatocytes exposed to low-concentration HBCDs
  260. Seaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2–ARE pathway
  261. Toll-like receptor signaling induces Nrf2 pathway activation through p62-triggered Keap1 degradation
  262. Oxidative stress and dysregulated Nrf2 activation in the pathogenesis of schizophrenia
  263. Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in Caenorhabditis elegans
  264. HER2 confers drug resistance of human breast cancer cells through activation of NRF2 by direct interaction
  265. Z‐Ligustilide inhibits benzo (a) pyrene‐induced CYP1A1 upregulation in cultured human keratinocytes via ROS‐dependent Nrf2 activation
  266. … are critical for oxidant/electrophile-sensing, Kelch-like ECH-associated protein-1-dependent ubiquitination-proteasomal degradation, and transcription activation
  267. Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response
  268. Characterization of RA839, a noncovalent small molecule binder to Keap1 and selective activator of Nrf2 signaling
  269. Decreased lectin-like oxidized LDL receptor 1 (LOX-1) and low Nrf2 activation in placenta are involved in preeclampsia
  270. α-Lipoic acid reduces infarct size and preserves cardiac function in rat myocardial ischemia/reperfusion injury through activation of PI3K/Akt/Nrf2 pathway
  271. Acrolein causes transcriptional induction of phase II genes by activation of Nrf2 in human lung type II epithelial (A549) cells
  272. Up-regulation of Nrf2-mediated heme oxygenase-1 expression by eckol, a phlorotannin compound, through activation of Erk and PI3K/Akt
  273. Sulforaphane protects rodent retinas against ischemia-reperfusion injury through the activation of the Nrf2/HO-1 antioxidant pathway
  274. Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation …
  275. Flunarizine induces Nrf2-mediated transcriptional activation of heme oxygenase-1 in protection of auditory cells from cisplatin
  276. Alteration of serum lipid profile, SRB1 loss, and impaired Nrf2 activation in CDKL5 disorder
  277. Nrf2-dependent activation of the antioxidant responsive element by tert-butylhydroquinone is independent of oxidative stress in IMR-32 human neuroblastoma cells
  278. Lycopene attenuates colistin-induced nephrotoxicity in mice via activation of the Nrf2/HO-1 pathway
  279. Diallyl sulfide enhances antioxidants and inhibits inflammation through the activation of Nrf2 against gentamicin-induced nephrotoxicity in Wistar rats
  280. Preconditioning by sesquiterpene lactone enhances H2O2-induced Nrf2/ARE activation
  281. N-acetylcysteine protects against liver injure induced by carbon tetrachloride via activation of the Nrf2/HO-1 pathway
  282. Activation of the UPR protects against cigarette smoke-induced RPE apoptosis through up-regulation of Nrf2
  283. Is there a sweet spot for Nrf2 activation in the treatment of diabetic kidney disease?
  284. Effect of diallyl sulfide on in vitro and in vivo Nrf2-mediated pulmonic antioxidant enzyme expression via activation ERK/p38 signaling pathway
  285. … inhibits the tumor necrosis factor-α-induced expression of cell adhesion molecules in endothelial cells by suppressing NF-κB activation: Effects upon IκB and Nrf2
  286. Nrf2 pathway activation contributes to anti-fibrosis effects of ginsenoside Rg1 in a rat model of alcohol-and CCl4-induced hepatic fibrosis
  287. Activation of the Nrf2-ARE pathway by siRNA knockdown of Keap1 reduces oxidative stress and provides partial protection from MPTP-mediated neurotoxicity
  288. Sulforaphane alleviates muscular dystrophy in mdx mice by activation of Nrf2
  289. A somatic mutation of the KEAP1 gene in malignant melanoma is involved in aberrant NRF2 activation and an increase in intrinsic drug resistance
  290. Cucurbitacins attenuate microglial activation and protect from neuroinflammatory injury through Nrf2/ARE activation and STAT/NF-κB inhibition
  291. Garlic attenuates cardiac oxidative stress via activation of PI3K/AKT/Nrf2-Keap1 pathway in fructose-fed diabetic rat
  292. Succination of Keap1 and activation of Nrf2-dependent antioxidant pathways in FH-deficient papillary renal cell carcinoma type 2
  293. Willow bark extract increases antioxidant enzymes and reduces oxidative stress through activation of Nrf2 in vascular endothelial cells and Caenorhabditis elegans
  294. Effects of monascin on anti-inflammation mediated by Nrf2 activation in advanced glycation end product-treated THP-1 monocytes and methylglyoxal-treated Wistar …
  295. Toward an understanding of the role of a catechol moiety in cancer chemoprevention: The case of copper‐ and o‐quinone‐dependent Nrf2 activation by a catechol …
  296. Propofol activation of the Nrf2 pathway is associated with amelioration of acute lung injury in a rat liver transplantation model
  297. Caffeic acid phenethyl ester activation of Nrf2 pathway is enhanced under oxidative state: structural analysis and potential as a pathologically targeted therapeutic …
  298. Forsythiaside inhibits cigarette smoke-induced lung inflammation by activation of Nrf2 and inhibition of NF-κB
  299. Drug resistance associates with activation of Nrf2 in MCF‐7/DOX cells, and wogonin reverses it by down‐regulating Nrf2‐mediated cellular defense response
  300. The flavonoid, eriodictyol, induces long-term protection in ARPE-19 cells through its effects on Nrf2 activation and phase 2 gene expression
  301. Protection from cyanide‐induced brain injury by the Nrf2 transcriptional activator carnosic acid
  302. Activation of the Nrf2–ARE pathway in muscle and spinal cord during ALS-like pathology in mice expressing mutant SOD1
  303. The role of the catecholic and the electrophilic moieties of caffeic acid in Nrf2/Keap1 pathway activation in ovarian carcinoma cell lines
  304. Cadmium induced cardiac oxidative stress in rats and its attenuation by GSP through the activation of Nrf2 signaling pathway
  305. Nrf2 signaling modulates cigarette smoke-induced complement activation in retinal pigmented epithelial cells
  306. Participation of protein kinase C in the activation of Nrf2 signaling by ischemic preconditioning in the isolated rabbit heart
  307. A Curcumin Derivative That Inhibits Vinyl Carbamate-Induced Lung Carcinogenesis via Activation of the Nrf2 Protective Response
  308. Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis (cyanoenone), a highly potent Nrf2 activator with a reversible covalent …
  309. Keap1 cysteine 288 as a potential target for diallyl trisulfide-induced Nrf2 activation
  310. Oleuropein and oleacein may restore biological functions of endothelial progenitor cells impaired by angiotensin II via activation of Nrf2/heme oxygenase-1 pathway
  311. 4-Hydroxy hexenal derived from docosahexaenoic acid protects endothelial cells via Nrf2 activation
  312. Nuclear factor-E2 (Nrf2) is regulated through the differential activation of ERK1/2 and PKC α/βII by Gymnasterkoreayne B
  313. Suppression of the Nrf2-dependent antioxidant response by glucocorticoids and 11β-HSD1-mediated glucocorticoid activation in hepatic cells
  314. EGFR-activated signaling and actin remodeling regulate cyclic stretch–induced NRF2-ARE activation
  315. Dietary Lycium barbarum Polysaccharide Induces Nrf2/ARE Pathway and Ameliorates Insulin Resistance Induced by High-Fat via Activation of PI3K/AKT …
  316. Nrf2–ARE activator carnosic acid decreases mitochondrial dysfunction, oxidative damage and neuronal cytoskeletal degradation following traumatic brain injury in …
  317. … acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal …
  318. MicroRNA/gene profiling unveils early molecular changes and nuclear factor erythroid related factor 2 (NRF2) activation in a rat model recapitulating human …
  319. Activation of mouse Pi-class glutathione S-transferase gene by Nrf2 (NF-E2-related factor 2) and androgen
  320. Flavonoids derived from liquorice suppress murine macrophage activation by up-regulating heme oxygenase-1 independent of Nrf2 activation
  321. Protective Effect of the Fruit Hull of Gleditsia sinensis on LPS-Induced Acute Lung Injury Is Associated with Nrf2 Activation
  322. Synthesis and bioevaluation of a series of α-pyrone derivatives as potent activators of Nrf2/ARE pathway (part I)
  323. Isothiocyanates protect against oxidized LDL‐induced endothelial dysfunction by upregulating Nrf2‐dependent antioxidation and suppressing NFκB activation
  324. Carbon monoxide mediates heme oxygenase 1 induction via Nrf2 activation in hepatoma cells
  325. Salvianolic acid B protects against acetaminophen hepatotoxicity by inducing Nrf2 and phase II detoxification gene expression via activation of the PI3K and …
  326. Nrf2 activation as a future target of therapy for chronic diseases
  327. 4-Hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of Nrf2
  328. Increased glutathione synthesis following Nrf2 activation by vanadyl sulfate in human chang liver cells
  329. Activation of NRF2 signaling in HEK293 cells by a first‐in‐class direct KEAP1‐NRF2 inhibitor
  330. Activation of the Nrf2 defense pathway contributes to neuroprotective effects of phloretin on oxidative stress injury after cerebral ischemia/reperfusion in rats
  331. Eriodictyol protects against H2O2-induced neuron-like PC12 cell death through activation of Nrf2/ARE signaling pathway
  332. PPARβ/δ ameliorates fructose-induced insulin resistance in adipocytes by preventing Nrf2 activation
  333. tBHQ inhibits LPS-induced microglial activation via Nrf2-mediated suppression of p38 phosphorylation
  334. Administration of the Nrf2–ARE activators sulforaphane and carnosic acid attenuates 4-hydroxy-2-nonenal-induced mitochondrial dysfunction ex vivo
  335. Selenite cataracts: activation of endoplasmic reticulum stress and loss of Nrf2/Keap1-dependent stress protection
  336. Oroxylin A exerts anti-inflammatory activity on lipopolysaccharide-induced mouse macrophage via Nrf2/ARE activation
  337. Nitroxide delivery system for Nrf2 activation and skin protection
  338. Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a …
  339. Sustained NRF2 activation in hereditary leiomyomatosis and renal cell cancer (HLRCC) and in hereditary tyrosinemia type 1 (HT1)
  340. MyD88 is a mediator for the activation of Nrf2
  341. Carnosic acid, a catechol‐type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S‐alkylation of …
  342. Structural influence of isothiocyanates on expression of cytochrome P450, phase II enzymes, and activation of Nrf2 in primary rat hepatocytes
  343. Dimethoxycurcumin, a synthetic curcumin analogue, induces heme oxygenase-1 expression through Nrf2 activation in RAW264. 7 macrophages
  344. The inhibitory effects of Geranium thunbergii on interferon-γ-and LPS-induced inflammatory responses are mediated by Nrf2 activation
  345. Epigallocatechin-3-gallate prevents TNF-α-induced NF-κB activation thereby upregulating ABCA1 via the Nrf2/Keap1 pathway in macrophage foam cells
  346. Chromium (VI)‐induced oxidative stress and apoptosis is reduced by garlic and its derivative S‐allylcysteine through the activation of Nrf2 in the hepatocytes of Wistar …
  347. Activation of the Nrf2-ARE pathway attenuates hyperglycemia-mediated injuries in mouse podocytes
  348. … -derived superoxide by notoginsenoside R1 protects against cerebral ischemia–reperfusion injury through estrogen receptor-dependent activation of Akt/Nrf2 …
  349. Continuous activation of Nrf2 and its target antioxidant enzymes leads to arsenite-induced malignant transformation of human bronchial epithelial cells
  350. Dimethylfumarate alleviates early brain injury and secondary cognitive deficits after experimental subarachnoid hemorrhage via activation of Keap1-Nrf2-ARE system
  351. Chitooligosaccharides inhibit ethanol-induced oxidative stress via activation of Nrf2 and reduction of MAPK phosphorylation
  352. … adriamycin-induced cardiotoxicity by improving endothelial dysfunction from oxidative stress via upregulating the Nrf2-ARE pathway through the activation of akt
  353. Luteolin, a bioflavonoid inhibits Azoxymethane-induced colorectal cancer through activation of Nrf2 signaling
  354. Grape seed proanthocyanidin extract ameliorates diabetic bladder dysfunction via the activation of the Nrf2 pathway
  355. Disulfiram targeting lymphoid malignant cell lines via ROS-JNK activation as well as Nrf2 and NF-kB pathway inhibition
  356. Auranofin, a gold (I)-containing antirheumatic compound, activates Keap1/Nrf2 signaling via Rac1/iNOS signal and mitogen-activated protein kinase activation
  357. Nrf2/HO‐1 pathway activation by manganese is associated with reactive oxygen species and ubiquitin–proteasome pathway, not MAPKs signaling
  358. … Latifolin Isolated from MeOH Extract of Dalbergia odorifera Attenuates Inflammatory Responses by Inhibiting NF‐κB Activation via Nrf2‐Mediated Heme Oxygenase …
  359. Protective effects of diallyl disulfide on carbon tetrachloride‐induced hepatotoxicity through activation of Nrf2
  360. S [+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis
  361. Redox mechanisms involved in the selective activation of Nrf2-mediated resistance versus p53-dependent apoptosis in adenocarcinoma cells
  362. Pharmacological activation of Nrf2 pathway improves pancreatic islet isolation and transplantation
  363. Inhibition of cytochrome P450 2E1 and activation of transcription factor Nrf2 are renoprotective in myoglobinuric acute kidney injury
  364. Activation of Nrf2 target enzymes conferring protection against oxidative stress in PC12 cells by ginger principal constituent 6-shogaol
  365. The antioxidative potential of farrerol occurs via the activation of Nrf2 mediated HO-1 signaling in RAW 264.7 cells
  366. Nrf2 expression and activity in human T lymphocytes: stimulation by T cell receptor activation and priming by inorganic arsenic and tert-butylhydroquinone
  367. … of dimerumic acid on hepatic fibrosis caused from carboxymethyl-lysine (CML) by attenuating oxidative stress depends on Nrf2 activation in hepatic stellate cells …
  368. Activation of the Nrf2 pathway by inorganic arsenic in human hepatocytes and the role of transcriptional repressor Bach1
  369. The NRF2 activation and antioxidative response are not impaired overall during hyperoxia-induced lung epithelial cell death
  370. Isolation, identification, and biological evaluation of Nrf2-ARE activator from the leaves of green perilla (Perilla frutescens var. crispa f. viridis)
  371. Anti-inflammatory efficacy of dexamethasone and Nrf2 activators in the CNS using brain slices as a model of acute injury
  372. Curcumin inhibits superoxide anion-induced pain-like behavior and leukocyte recruitment by increasing Nrf2 expression and reducing NF-κB activation
  373. Enhanced CD36 expression changes the role of Nrf2 activation from anti-atherogenic to pro-atherogenic in apoE-deficient mice
  374. Alpha-lipoic acid regulates heme oxygenase gene expression and nuclear Nrf2 activation as a mechanism of protection against arsenic exposure in HepG2 cells
  375. Extracellular DNA oxidation stimulates activation of NRF2 and reduces the production of ROS in human mesenchymal stem cells
  376. Ethanol extract of peanut sprout induces Nrf2 activation and expression of antioxidant and detoxifying enzymes in human dermal fibroblasts: Implication for its …
  377. ent-kaur-16-en-19-oic Acid, isolated from the roots of Aralia continentalis, induces activation of Nrf2
  378. Melatonin induces the expression of Nrf2-regulated antioxidant enzymes via PKC and Ca2+ influx activation in mouse pancreatic acinar cells
  379. Activation of Nrf2-ARE signal pathway in hippocampus of amygdala kindling rats
  380. Bruton’s tyrosine kinase is required for TLR-dependent heme oxygenase-1 gene activation via Nrf2 in macrophages
  381. Ginsenoside Rb1 improves postoperative fatigue syndrome by reducing skeletal muscle oxidative stress through activation of the PI3K/Akt/Nrf2 pathway in aged rats
  382. Activation of Keap1/Nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells
  383. Shikonin inhibits oxidized LDL-induced monocyte adhesion by suppressing NFκB activation via up-regulation of PI3K/Akt/Nrf2-dependent antioxidation in EA. hy926 …
  384. Attenuation of NF-κB and activation of Nrf2 signaling by 1, 2, 4-triazine derivatives, protects neuron-like PC12 cells against apoptosis
  385. Protective effects of erythropoietin in traumatic spinal cord injury by inducing the Nrf2 signaling pathway activation
  386. Melatonin antagonizes Mn-induced oxidative injury through the activation of keap1–Nrf2–ARE signaling pathway in the striatum of mice
  387. Phosphorylation and dephosphorylation of tyrosine 141 regulate stability and degradation of INrf2: a novel mechanism in Nrf2 activation
  388. The activation of Nrf2 and its downstream regulated genes mediates the antioxidative activities of xueshuan xinmaining tablet in human umbilical vein …
  389. Deprenyl prevents MPP+-induced oxidative damage in PC12 cells by the upregulation of Nrf2-mediated NQO1 expression through the activation of PI3K/Akt and Erk
  390. Histone acetyltransferase MOZ acts as a co-activator of Nrf2–MafK and induces tumour marker gene expression during hepatocarcinogenesis
  391. Eckol enhances heme oxygenase-1 expression through activation of Nrf2/JNK pathway in HepG2 cells
  392. Sulforaphane protects Microcystin-LR-induced toxicity through activation of the Nrf2-mediated defensive response
  393. … effects of β-hydroxyisovalerylshikonin in BV2 microglia are mediated through suppression of the PI3K/Akt/NF-kB pathway and activation of the Nrf2/HO-1 pathway
  394. Antioxidant effects of hydrogen sulfide on left ventricular remodeling in smoking rats are mediated via PI3K/Akt-dependent activation of Nrf2
  395. The Ras GTPase-activating-like protein IQGAP1 mediates Nrf2 protein activation via the mitogen-activated protein kinase/extracellular signal-regulated kinase …
  396. Gold nanoparticles induce heme oxygenase-1 expression through Nrf2 activation and Bach1 export in human vascular endothelial cells
  397. Reactivity of Chemical Sensitizers Toward Amino Acids In Cellulo Plays a Role in the Activation of the Nrf2-ARE Pathway in Human Monocyte Dendritic Cells and the …
  398. 3, 4, 5-Trihydroxycinnamic acid inhibits lipopolysaccharide (LPS)-induced inflammation by Nrf2 activation in vitro and improves survival of mice in LPS-induced …
  399. Role of Nrf2 in neurodegenerative diseases and recent progress of its activators
  400. Nelumbo nucifera leaves protect hydrogen peroxide-induced hepatic damage via antioxidant enzymes and HO-1/Nrf2 activation
  401. Activation of Nrf2-antioxidant response element mediated glutamate cysteine ligase expression in hepatoma cell line by homocysteine
  402. Chitooligosaccharides Attenuate Cu2+-Induced Cellular Oxidative Damage and Cell Apoptosis Involving Nrf2 Activation
  403. 1, 5-Dicaffeoylquinic acid-mediated glutathione synthesis through activation of Nrf2 protects against OGD/reperfusion-induced oxidative stress in astrocytes
  404. Akt and ERK/Nrf2 activation by PUFA oxidation-derived aldehydes upregulates FABP4 expression in human macrophages
  405. Activation of the Nrf2-ARE pathway in hepatocytes protects against steatosis in nutritionally induced non-alcoholic steatohepatitis in mice
  406. Prunella vulgaris Suppresses HG-Induced Vascular Inflammation via Nrf2/HO-1/eNOS Activation
  407. Nrf2 activation in the liver of rats subjected to a preconditioning sub-chronic iron protocol
  408. … of NO and PGE2 in LPS-stimulated BV2 microglial cells by trans-isoferulic acid via suppression of PI3K/Akt-dependent NF-κB and activation of Nrf2-mediated HO-1
  409. P90RSK and Nrf2 activation via MEK1/2-ERK1/2 pathways mediated by notoginsenoside R2 to prevent 6-hydroxydopamine-induced apoptotic death in SH …
  410. Cardioprotective role of P38 MAPK during myocardial infarction via parallel activation of α‐crystallin B and Nrf2
  411. A novel kavalactone derivative protects against H2O2-induced PC12 cell death via Nrf2/ARE activation
  412. … to diesel exhaust particle extracts (DEPe) impairs some polarization markers and functions of human macrophages through activation of AhR and Nrf2
  413. Antroquinonol differentially modulates T cell activity and reduces interleukin‐18 production, but enhances Nrf2 activation, in murine accelerated severe lupus nephritis
  414. Activation of the Nrf2/ARE pathway via S-alkylation of cysteine 151 in the chemopreventive agent-sensor Keap1 protein by falcarindiol, a conjugated diacetylene …
  415. Control of cellular redox status and upregulation of quinone reductase NQO1 via Nrf2 activation by α-lipoic acid in human leukemia HL-60 cells
  416. Oleanolic acid attenuates obstructive cholestasis in bile duct-ligated mice, possibly via activation of NRF2-MRPs and FXR antagonism
  417. Antioxidative stress effect of phosphoserine dimers is mediated via activation of the Nrf2 signaling pathway
  418. Ketamine reduces LPS-induced HMGB1 via activation of the Nrf2/HO-1 pathway and NF-κB suppression
  419. … AITC attenuate methylglyoxal-induced PPARγ phosphorylation and degradation through inhibition of the oxidative stress/PKC pathway depending on Nrf2 activation
  420. Panaxatriol saponins attenuated oxygen-glucose deprivation injury in PC12 cells via activation of PI3K/Akt and Nrf2 signaling pathway
  421. Modulation of nuclear factor E2-related factor-2 (Nrf2) activation by the stress response gene immediate early response-3 (IER3) in colonic epithelial cells: a …
  422. Eriodictyol Attenuates β-amyloid 25–35 peptide-induced oxidative cell death in primary cultured neurons by activation of Nrf2
  423. 3, 4, 5-Trihydroxycinnamic acid inhibits lipopolysaccharide-induced inflammatory response through the activation of Nrf2 pathway in BV2 microglial cells
  424. Synthesis of piperlongumine analogues and discovery of nuclear factor erythroid 2-related factor 2 (Nrf2) activators as potential neuroprotective agents
  425. … response and enhancement of PC12 cell tolerance by lipopolysaccharide primarily through the upregulation of glutathione S-transferase A3 via Nrf2 activation
  426. A kavalactone derivative inhibits lipopolysaccharide-stimulated iNOS induction and NO production through activation of Nrf2 signaling in BV2 microglial cells
  427. Dangkwisoo-san, an herbal medicinal formula, ameliorates acute lung inflammation via activation of Nrf2 and suppression of NF-κB
  428. Thymoquinone induces heme oxygenase-1 expression in HaCaT cells via Nrf2/ARE activation: Akt and AMPKα as upstream targets
  429. … hydrogen sulfide modulator, S-propargyl-cysteine, on high glucose-induced apoptosis in cardiomyocytes: a novel mechanism mediated by the activation of Nrf2
  430. Of mice, rats, and men: could Nrf2 activation protect against aflatoxin heptocarcinogenesis in humans?
  431. Molecular effects of baicalein in Hct116 cells and Caenorhabditis elegans: activation of the Nrf2 signaling pathway and prolongation of lifespan
  432. Icaritin attenuates cigarette smoke-mediated oxidative stress in human lung epithelial cells via activation of PI3K-AKT and Nrf2 signaling
  433. Nrf2 Activation Enhances Biliary Excretion of Sulfobromophthalein by Inducing Glutathione-S-Transferase Activity
  434. Activation of the transcription factor Nrf2 in macrophages, Caco-2 cells and intact human gut tissue by Maillard reaction products and coffee
  435. Nrf2, not the estrogen receptor, mediates catechol estrogen-induced activation of the antioxidant responsive element
  436. Breakdown products of neoglucobrassicin inhibit activation of Nrf2 target genes mediated by myrosinase-derived glucoraphanin hydrolysis products
  437. Lico A Enhances Nrf2-Mediated Defense Mechanisms against t-BHP-Induced Oxidative Stress and Cell Death via Akt and ERK Activation in RAW 264.7 …
  438. … -induced INrf2 (Keap1) tyrosine 85 phosphorylation controls the nuclear export and degradation of the INrf2–Cul3–Rbx1 complex to allow normal Nrf2 activation and …
  439. Activation of Nrf2/HO-1signaling pathway involves the anti-inflammatory activity of magnolol in Porphyromonas gingivalis lipopolysaccharide-stimulated mouse RAW …
  440. Autophagy deficiency diminishes indomethacin-induced intestinal epithelial cell damage through activation of the ERK/Nrf2/HO-1 pathway
  441. Catechol estrogens mediated activation of Nrf2 through covalent modification of its quinone metabolite to Keap1
  442. Neuroprotection against 6-OHDA-induced oxidative stress and apoptosis in SH-SY5Y cells by 5, 7-Dihydroxychromone: Activation of the Nrf2/ARE pathway
  443. Pro-oxidants ameliorate radiation-induced apoptosis through activation of the calcium–ERK1/2–Nrf2 pathway
  444. Involvement of activation of the Nrf2/ARE pathway in protection against 6-OHDA-induced SH-SY5Y cell death by α-iso-cubebenol
  445. Induction of activation of the antioxidant response element and stabilization of Nrf2 by 3-(3-pyridylmethylidene)-2-indolinone (PMID) confers protection against …
  446. Inhibition of LXRα-dependent steatosis and oxidative injury by liquiritigenin, a licorice flavonoid, as mediated with Nrf2 activation
  447. … water concentrate and its active component shikimic acid against hydroperoxide mediated oxidative stress through suppression of NF-κB and activation of Nrf2 …
  448. Effect of glutathione depletion on Nrf2/ARE activation by deltamethrin in PC12 Cells
  449. Norepinephrine provides short-term neuroprotection against Aβ1–42 by reducing oxidative stress independent of Nrf2 activation
  450. The role of sulfhydryl reactivity of small molecules for the activation of the KEAP1/NRF2 pathway and the heat shock response
  451. Comment on hydroxytyrosol induces proliferation and cytoprotection against oxidative injury in vascular endothelial cells: role of Nrf2 activation and HO-1 …
  452. Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers
  453. Glucose reintroduction triggers the activation of Nrf2 during experimental ischemia reperfusion
  454. Novel Nrf2/ARE Activator, trans-Coniferylaldehyde, Induces a HO-1-Mediated Defense Mechanism through a Dual p38α/MAPKAPK-2 and PK-N3 Signaling Pathway
  455. Inhibition of neointimal formation by trans‐resveratrol: Role of phosphatidyl inositol 3‐kinase‐dependent Nrf2 activation in heme oxygenase‐1 induction
  456. Cordyceps sinensis Increases Hypoxia Tolerance by Inducing Heme Oxygenase-1 and Metallothionein via Nrf2 Activation in Human Lung Epithelial Cells
  457. Activation of NRF2 pathway in spleen, thymus as well as peripheral blood mononuclear cells by acute arsenic exposure in mice
  458. Sulforaphane homologues: Enantiodivergent synthesis of both enantiomers, activation of the Nrf2 transcription factor and selective cytotoxic activity
  459. Taurine chloramine induces heme oxygenase-1 expression via Nrf2 activation in murine macrophages
  460. Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2)
  461. Schisandra chinensis regulates drug metabolizing enzymes and drug transporters via activation of Nrf2-mediated signaling pathway
  462. Activation of Nrf2 Is Required for Up-Regulation of the π Class of Glutathione S-Transferase in Rat Primary Hepatocytes with l-Methionine Starvation
  463. … -induced changes in cellular redox status and HO-1 upregulation are FGFR-dependent and proceed through both ERK and AKT to induce CREB and Nrf2 activation
  464. Curcumin analog 1, 5-bis (2-trifluoromethylphenyl)-1, 4-pentadien-3-one exhibits enhanced ability on Nrf2 activation and protection against acrolein-induced ARPE …
  465. Rat H9c2 cardiac myocytes are sensitive to arsenite due to a modest activation of transcription factor Nrf2
  466. Irradiation inhibits the maturation and mineralization of osteoblasts via the activation of Nrf2/HO-1 pathway
  467. DHEA alleviates oxidative stress of muscle cells via activation of Nrf2 pathway
  468. Squid ink polysaccharide reduces cyclophosphamide-induced testicular damage via Nrf2/ARE activation pathway in mice
  469. Chamomile confers protection against hydrogen peroxide‐induced toxicity through activation of nrf2‐mediated defense response
  470. Fragrant unsaturated aldehydes elicit activation of the Keap1/Nrf2 system leading to the upregulation of thioredoxin expression and protection against oxidative stress
  471. New monocyclic, bicyclic, and tricyclic ethynylcyanodienones as activators of the Keap1/Nrf2/ARE pathway and inhibitors of inducible nitric oxide synthase
  472. CYP2C8-derived epoxyeicosatrienoic acids decrease oxidative stress-induced endothelial apoptosis in development of atherosclerosis: role of Nrf2 activation
  473. Naphthazarin protects against glutamate-induced neuronal death via activation of the Nrf2/ARE pathway
  474. … of 7, 8-dihydroxyflavone against oxidative stress are mediated by the upregulation of Nrf2-dependent HO-1 expression through the activation of the PI3K/Akt …
  475. The combination of the active principles of Podophyllum hexandrum supports early recovery of the gastrointestinal system via activation of Nrf2-HO-1 signaling and …
  476. Lipopolysaccharide preconditioning attenuates neuroapoptosis and improves functional recovery through activation of Nrf2 in traumatic spinal cord injury rats
  477. MDA-7/IL-24 inhibits Nrf2-mediated antioxidant response through activation of p38 pathway and inhibition of ERK pathway involved in cancer cell apoptosis
  478. Persistent expression of Nqo1 by p62-mediated Nrf2 activation facilitates p53-dependent mitotic catastrophe
  479. … than resveratrol in preventing azoxymethane (AOM)-induced colon tumorigenesis via activation of the NF-E2-related factor 2 (Nrf2)-mediated antioxidant signaling …
  480. Novel oxime-bearing coumarin derivatives act as potent Nrf2/ARE activators in vitro and in mouse model
  481. … grandiflorum root-derived saponins attenuate atopic dermatitis-like skin lesions via suppression of NF-κB and STAT1 and activation of Nrf2/ARE-mediated heme …
  482. Dwindling of cardio damaging effect of isoproterenol by Punica granatum L. peel extract involve activation of nitric oxide-mediated Nrf2/ARE signaling pathway and …
  483. Danshensu protects isolated heart against ischemia reperfusion injury through activation of Akt/ERK1/2/Nrf2 signaling
  484. Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation
  485. Dihydro-CDDO-trifluoroethyl amide suppresses inflammatory responses in macrophages via activation of Nrf2
  486. Lycopene improves activation of antioxidant system and Nrf2/HO-1 pathway of muscle in rainbow trout (Oncorhynchus mykiss) with different stocking densities
  487. … ‑tocotrienol prevents 5‑FU‑induced reactive oxygen species production in human oral keratinocytes through the stabilization of 5‑FU‑induced activation of Nrf2
  488. Piceatannol induces heme oxygenase-1 expression in human mammary epithelial cells through activation of ARE-driven Nrf2 signaling
  489. Identifying panaxynol, a natural activator of nuclear factor erythroid-2 related factor 2 (Nrf2) from American ginseng as a suppressor of inflamed macrophage-induced …
  490. An IκBα phosphorylation inhibitor induces heme oxygenase-1 (HO-1) expression through the activation of reactive oxygen species (ROS)–Nrf2–ARE signaling and …
  491. Bucillamine induces glutathione biosynthesis via activation of the transcription factor Nrf2
  492. Activation of alveolar macrophages with interferon-γ promotes antioxidant defenses via the Nrf2-ARE pathway
  493. Genetic or pharmacologic activation of Nrf2 signaling fails to protect against aflatoxin genotoxicity in hypersensitive GSTA3 knockout mice
  494. Discovery of oxime-bearing naphthalene derivatives as a novel structural type of Nrf2 activators
  495. Activation of Nrf2/Keap1 signaling and autophagy induction against oxidative stress in heart in iron deficiency
  496. Quinone-induced activation of Keap1/Nrf2 signaling by aspirin prodrugs masquerading as nitric oxide
  497. Baicalein protects against 6-OHDA-induced neurotoxicity through activation of Keap1/Nrf2/HO-1 and involving PKCα and PI3K/AKT signaling pathways
  498. 15‐Deoxy‐Δ12,14‐prostaglandin J2 Induces Upregulation of Multidrug Resistance‐Associated Protein 1 via Nrf2 Activation in Human Breast Cancer Cells
  499. 15-Deoxy-Δ12, 14-prostaglandin J2 modulates manganese-induced activation of the NF-κB, Nrf2, and PI3K pathways in astrocytes
  500. Highly Potent Activation of Nrf2 by Topical Tricyclic Bis(Cyano Enone): Implications for Protection against UV Radiation during Thiopurine Therapy
  501. Reactive sulfur species-mediated activation of the Keap1–Nrf2 pathway by 1, 2-naphthoquinone through sulfenic acids formation under oxidative stress
  502. Mechanism of heme oxygenase-1 gene activation by cadmium in MCF-7 mammary epithelial cells: role of p38 kinase and Nrf2 transcription factor
  503. Ascorbic acid reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and improves survival rate in septic mice by activation of Nrf2/HO-1 signals
  504. Nrf2 and HSF-1 pathway activation via hydroquinone-based proelectrophilic small molecules is regulated by electrochemical oxidation potential
  505. Astaxanthin protects ARPE-19 cells from oxidative stress via upregulation of Nrf2-regulated phase II enzymes through activation of PI3K/Akt
  506. Pyrroloquinoline quinone rescues hippocampal neurons from glutamate-induced cell death through activation of Nrf2 and up-regulation of antioxidant genes
  507. Epigallocatechin gallate exacerbates fluoride-induced oxidative stress mediated testicular toxicity in rats through the activation of Nrf2 signaling pathway
  508. Actinidia callosa peel (kiwi fruit) ethanol extracts protected neural cells apoptosis induced by methylglyoxal through Nrf2 activation
  509. Nrf2 activation, an innovative therapeutic alternative in cerebral ischemia
  510. Role of growth hormone in maturation and activation of dendritic cells via miR‐200a and the Keap1/Nrf2 pathway
  511. Propofol pretreatment attenuates remote kidney injury induced by orthotopic liver autotransplantation, which is correlated with the activation of Nrf2 in rats
  512. Capsaicin Induces Heme Oxygenase-1 Expression in HepG2 Cells Via Activation of PI3K-Nrf2 Signaling: NAD(P)H:Quinone Oxidoreductase as a Potential Target
  513. Propofol attenuates lipopolysaccharide-induced reactive oxygen species production through activation of Nrf2/GSH and suppression of NADPH oxidase in human …
  514. … TNFα-induced ICAM-1 expression via suppression of NADPH oxidase activation and induction of HO-1 and GCLM expression through the PI3K/Akt/Nrf2 and PI3K/Akt …
  515. Activation of Nrf2 Pathways Correlates with Resistance of NSCLC Cell Lines to CBP501 In Vitro
  516. Identification of UV-protective activators of nuclear factor erythroid-derived 2-related factor 2 (Nrf2) by combining a chemical library screen with computer …
  517. CO/HO-1 induces NQO-1 expression via Nrf2 activation
  518. Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: modulation by the Nrf2/Trx axis
  519. Glutathione biosynthesis via activation of the nuclear factor E2–related factor 2 (Nrf2)–antioxidant-response element (ARE) pathway is essential for neuroprotective …
  520. Performance of the N/TERT epidermal model for skin sensitizer identification via Nrf2-Keap1-ARE pathway activation
  521. MicroRNA/gene profiling unveils early molecular changes and NRF2 activation in a rat model recapitulating human HCC.
  522. Amplified in breast cancer 1 enhances human cholangiocarcinoma growth and chemoresistance by simultaneous activation of Akt and Nrf2 pathways
  523. Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/Akt-dependent activation of Nrf2
  524. Homocysteine induces heme oxygenase-1 expression via transcription factor Nrf2 activation in HepG2 cells
  525. Protolichesterinic acid derivatives: α-methylene-γ-lactones as potent dual activators of PPARγ and Nrf2 transcriptional factors
  526. Induction of phase 2 enzymes by serum oxidized polyamines through activation of Nrf2: effect of the polyamine metabolite acrolein
  527. Nitroalkene fatty acids mediate activation of Nrf2/ARE-dependent and PPARγ-dependent transcription by distinct signaling pathways and with significantly different …
  528. … Effect of Chung-Pae, an Experimental Herbal Formula, on Acute Lung Inflammation Is Associated with Suppression of NF-κB and Activation of Nrf2
  529. Downregulation of Nrf2/HO-1 pathway and activation of JNK/c-Jun pathway are involved in homocysteic acid-induced cytotoxicity in HT-22 cells
  530. Activation of the Mouse Heme Oxygenase-1 Gene by 15-Deoxy-Δ12,14-Prostaglandin J2 Is Mediated by the Stress Response Elements and Transcription Factor …
  531. Dual TNFα-induced effects on NRF2 mediated antioxidant defence in astrocyte-rich cultures: role of protein kinase activation
  532. Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus …
  533. [18] Roles of Nrf2 in activation of antioxidant enzyme genes via antioxidant responsive elements
  534. Naringenin protects against 6-OHDA-induced neurotoxicity via activation of the Nrf2/ARE signaling pathway
  535. … oxyacantha L.) Bark Extract Regulates Antioxidant Response Element (ARE)‐Mediated Enzyme Expression Via Nrf2 Pathway Activation in Normal Hepatocyte Cell …
  536. Baicalin Ameliorates H2O2 Induced Cytotoxicity in HK-2 Cells through the Inhibition of ER Stress and the Activation of Nrf2 Signaling
  537. … Keratinocyte HaCaT Cells against H2O2‐Induced Oxidative Stress and Apoptosis through Upregulation of HO‐1 Expression via Activation of the PI3K/Akt/Nrf2 …
  538. Involvement of Nrf2 activation in the upregulation of S100A9 by exposure to inorganic arsenite
  539. Effects of that ATRA inhibits Nrf2-ARE pathway on glial cells activation after intracerebral hemorrhage
  540. Heterocyclic chalcone activators of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) with improved in vivo efficacy
  541. Dopaminergic neuroprotection via Nrf2-ARE pathway activation: identification of an activator from green perilla leaves
  542. … CoPP) protects human cardiac stem cells against apoptosis through activation of the extracellular signal-regulated kinase (ERK)/NRF2 signaling pathway and …
  543. Dual pathways of p53 mediated glucolipotoxicity-induced apoptosis of rat cardiomyoblast cell: activation of p53 proapoptosis and inhibition of Nrf2-NQO1 …
  544. … extract of Ecklonia cava against oxidative stress are associated with upregulation of Nrf2-mediated HO-1 and NQO-1 expression through activation of the MAPK …
  545. Polymeric procyanidin fraction from defatted grape seeds protects HepG2 cells against oxidative stress by inducing phase II enzymes via Nrf2 activation
  546. … : S-allyl cysteine protects against 6-hydroxydopamine-induced neurotoxicity in the rat striatum: Involvement of Nrf2 transcription factor activation and modulation of …
  547. … of the mushroom Mycoleptodonoides aitchisonii induces a series of anti-oxidative and phase II detoxifying enzymes through activation of the transcription factor Nrf2
  548. Tanshinone IIA protects against triptolide-induced liver injury via Nrf2/ARE activation
  549. 15-Deoxy-prostaglandin J2 anti-inflammation in a rat model of chronic obstructive pulmonary disease and human bronchial epithelial cells via Nrf2 activation
  550. Activation of the Nrf2 pathway, but decreased γ-glutamylcysteine synthetase heavy subunit chain levels and caspase-3-dependent apoptosis during exposure of …
  551. Activation of the Nrf2-antioxidant system by a novel cyclooxygenase-2 inhibitor furan-2-yl-3-pyridin-2-yl-propenone: implication in anti-inflammatory function by Nrf2 …
  552. Traumatic brain injury induces the activation of the Nrf2-ARE pathway in the lung in rats
  553. Induction of NAD (P) H: quinone oxidoreductase 1 expression by cysteine via Nrf2 activation in human intestinal epithelial LS180 cells
  554. Nuclear factor E2-related factor-2 (Nrf2) is required for NLRP3 and AIM2 inflammasome activation
  555. Activation of the Kelch-like ECH-associated protein 1 (Keap1)/NF-E2-related factor 2 (Nrf2) pathway through covalent modification of the 2-alkenal group of aliphatic …
  556. 5-Aminolevulinic acid combined with sodium ferrous citrate ameliorates H2O2-induced cardiomyocyte hypertrophy via activation of the MAPK/Nrf2/HO-1 pathway
  557. Activation of Nrf2 restores klotho expression and attenuates oxidative stress and inflammation in CKD
  558. Fucoxanthin enhances HO-1 and NQO1 expression in murine hepatic BNL CL. 2 cells through activation of the Nrf2/ARE system partially by its pro-oxidant activity
  559. … -1 in response to nitrosative stress induces expression of glutamate-cysteine ligase in PC12 cells via activation of phosphatidylinositol 3-kinase and Nrf2 …
  560. Synergistic activation of the Nrf2-signaling pathway by glyceollins under oxidative stress induced by glutathione depletion
  561. Ferulic acid induces heme oxygenase-1 via activation of ERK and Nrf2
  562. Inhibition of 6-hydroxydopamine-induced endoplasmic reticulum stress by sulforaphane through the activation of Nrf2 nuclear translocation
  563. Inhibition of NO-induced β-cell death by novel NF-κB inhibitor (−)-DHMEQ via activation of Nrf2–ARE pathway
  564. Chlorella ethanol extract induced phase II enzyme through NFE2L2 (nuclear factor [erythroid-derived] 2-like 2, NRF2) activation and protected ethanol-induced …
  565. … inhibit UVB-Induced MMP expression and promote type I procollagen production via repression of MAPK/AP-1/NF-κB and activation of AMPK/Nrf2 in HaCaT cells and …
  566. Zerumbone induces heme oxygenase-1 expression in mouse skin and cultured murine epidermal cells through activation of Nrf2
  567. Site-specific modification of the electrophile sensor protein Keap1 and activation of Nrf2-dependent gene expression
  568. Inhibition of AP-1 and MAPK signaling and activation of Nrf2/ARE pathway by quercitrin
  569. … -mediated neuroprotection involves estrogen receptor-dependent crosstalk between Akt and ERK1/2 pathways: a novel mechanism of Nrf2/ARE signaling activation
  570. Molecular mechanisms involved in enhancing HO-1 expression: de-repression by heme and activation by Nrf2, the” one-two” punch
  571. Attenuation of Aβ25–35-induced parallel autophagic and apoptotic cell death by gypenoside XVII through the estrogen receptor-dependent activation of Nrf2/ARE …
  572. Tert-Butylhydroquinone as a Phenolic Activator of Nrf2 Antagonizes Arsenic-Induced Oxidative Cytotoxicity but Promotes Arsenic Methylation and Detoxication in …
  573. Oxidative stress in multiple sclerosis pathology and therapeutic potential of Nrf2 activation
  574. Relationships between level of lipid peroxidation products and expression of Nrf2 and its activators/inhibitors in non-small cell lung cancer tissue
  575. Analytical approaches for quantification of a Nrf2 pathway activator: overcoming bioanalytical challenges to support a toxicity study
  576. Activation of nuclear factor-erythroid 2-related factor 2 (Nrf2) in the basilar artery after subarachnoid hemorrhage in rats
  577. Maslinic acid induces HO-1 and NOQ1 expression via activation of Nrf2 transcription factor
  578. … ∆ 2-pioglitazone, an analogue of pioglitazone, on colon cancer cell survival: Evidence of drug treatment association with autophagy and activation of the Nrf2 …
  579. … and hexane fractions from Orostachys japonicus in LPS-stimulated RAW 264.7 cells via upregulation of Nrf2 expression and activation of MAPK signaling …
  580. Cyclo (His‐Pro) up‐regulates heme oxygenase 1 via activation of Nrf2‐ARE signalling
  581. Methionine sulfoxide reductase A attenuates heme oxygenase-1 induction through inhibition of Nrf2 activation
  582. Lipoxin A4-Induced Heme Oxygenase-1 Protects Cardiomyocytes against Hypoxia/Reoxygenation Injury via p38 MAPK Activation and Nrf2/ARE Complex
  583. Guggulsterone induces heme oxygenase-1 expression through activation of Nrf2 in human mammary epithelial cells: PTEN as a putative target
  584. Simultaneous Activation of Nrf2 and Elevation of Antioxidant Chemicals in Management of Post-Traumatic Stress Disorders and Traumatic Brain Injury.
  585. Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2
  586. Withdrawal: Hsp90 interaction with INrf2 (Keap1) mediates stress-induced Nrf2 activation.
  587. Apomorphine protects against 6‐hydroxydopamine‐induced neuronal cell death through activation of the Nrf2‐ARE pathway
  588. Sulfhydryl-reactive phytochemicals as dual activators of transcription factors NRF2 and HSF1
  589. Protective Effects of BML-111 on Cerulein-Induced Acute Pancreatitis-Associated Lung Injury via Activation of Nrf2/ARE Signaling Pathway
  590. Acute exposure to 3‐methylcholanthrene induces hepatic oxidative stress via activation of the Nrf2/ARE signaling pathway in mice
  591. Involvement of heme oxygenase-1 induction via Nrf2/ARE activation in protection against H2O2-induced PC12 cell death by a metabolite of sesamin contained in …
  592. Curcumin reduces paraquat-induced oxidative injury in A549 cells by activation of the Nrf2-ARE pathway
  593. ERK1/2 activation in quercetin-treated BEAS-2B cell plays a role in Nrf2-driven HO-1 expression
  594. Preconditioning with Gua Lou Gui Zhi decoction enhances H2O2‑induced Nrf2/HO‑1 activation in PC12 cells
  595. Activation of Nrf2 by toxic bile acids provokes adaptive defense responses to enhance cell survival at the emergence of oxidative stress
  596. … on LPS-induced NO and PGE2 production in BV2 microglial cells via inhibition of ROS/PI3K/Akt-mediated NF-κB signaling and activation of Nrf2-dependent HO-1
  597. Chemoenzymatic synthesis of (2 R, 3 R, 4 R)-dehydroxymethylepoxyquinomicin (DHMEQ), a new activator of antioxidant transcription factor Nrf2
  598. DJ-1 mediates the delayed cardioprotection of hypoxic preconditioning through activation of Nrf2 and subsequent upregulation of antioxidative enzymes
  599. Antioxidant defense: Effects of an NRF2 ARE polymorphism on the activation of phase II enzymes
  600. Flavonoid naringin inhibits microglial activation and exerts neuroprotection against deltamethrin induced neurotoxicity through Nrf2/ARE signaling in the cortex and …
  601. Activation of NRF2 coordinates DDAH/PPAR-γ/ENOS pathways that enhance nitric oxide generation in human glomerular endothelial cells
  602. Correction: TNF mediates the sustained activation of Nrf2 in human monocytes
  603. Dual energy precursor and Nrf2 activator treatment additively improve redox glutathione levels and neuron survival in aging and in Alzheimer mouse neurons …
  604. Long-term cadmium exposure impairs activation of Nrf2-mediated defense mechanism
  605. The Nrf2-ARE activation protect neurones against oxidative stress
  606. The Nrf2 activator, tBHQ, exacerbates immediate hypersensitivity response to food allergen (HYP7P. 315)
  607. Nrf2 cysteine residues are critical for oxidant/electrophile-sensing, Keap1-dependent ubiquitination-proteasomal degradation, and transcription activation
  608. Activation of the Nrf2-ARE pathway as a therapeutic strategy in Parkinson’s disease
  609. … L. inhibits the lipopolysaccharide‐induced inflammatory response in RAW264. 7 macrophages through haem oxygenase‐1 induction and activation of the Nrf2 …
  610. P179 Celecoxib-mediated activation of an AMPK-CREB-Nrf2 dependent pathway: a novel mechanism for endothelial cytoprotection in chronic systemic inflammation
  611. The role of sulforaphane on duchenne muscular dystrophy by activation of Nrf2
  612. Nrf2 activation protects cells from HEMA-induced apoptosis
  613. Dimethyl Fumarate and Monoethyl Fumarate Exhibit Differential Effects on Glutathione, Keap1 and Nrf2 Activation In Vitro (P1. 204)
  614. Magnolia bark extract is a potent Nrf2 activator
  615. An Nrf2 activator, oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice
  616. Neuroprotective effect of Chinese herbal monomers and extracts via activation of Nrf2 signal pathway
  617. Inhibition of IFN production by the Nrf2 activators, tBHQ and BHA, in activated murine T cells
  618. Defect of Nrf2-ARE signaling activation in corneal stromal cells of keratoconus
  619. Heme oxygenase-1 induction through p38 MAPK/Nrf2 activation by ethanol extract of Artemisia capillaries inhibits LPS-activated iNOS, COX-2, and HMGB1 in …
  620. Schisandrin B protects against nephrotoxicity induced by cisplatin in HK-2 cells via Nrf2-ARE activation
  621. GW26-e2968 Selenium prevents from atherosclerosis formation by maintaining antioxidant activation through the Akt/GSK3β/Nrf2 axis in diabetes
  622. Cheogjogupye-tang has anti-oxidant potential through the activation of Nrf2
  623. Homocysteine induces heme oxygenase-1 expression via transcription factor Nrf2 activation in HepG2 Cells
  624. Activation of Nrf2 by Exercise Training and Curcumin Contributes to Sympatho-Inhibition in Heart Failure
  625. Activation of Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) enhances cyclooxygenase 2 expression via promoter antioxidant response element in preglomerular …
  626. Aged garlic extract reduces ROS production and cell death induced by 6-hydroxydopamine through activation of the Nrf2-ARE pathway in SH-SY5Y cells
  627. Analysis of the activation of the Nrf2-ARE pathway following optic nerve injury in mice
  628. Inhibition of liver fibrosis by solubilized coenzyme Q10: Role of Nrf2 activation in inhibiting transforming growth factor-β1 expression
  629. Activation of nuclear receptors CAR and NRF2 by garlic and garlic constituents
  630. Unconjugated Bilirubin mediated oxidative stress, ER stress, and activation of Nrf2 pathway
  631. Taxifolin Exerts Cytoprotective Effect by Activation of Nrf2-ARE Signaling Pathway in HepG2 cells
  632. Nrf2 pathway activation regulates radiation resistance in lung squamous cell carcinoma
  633. Determination of the Effects of Nrf2 upon the Early Events of Jurkat T Cell Activation by Use of CRISPR‐CAS9 Mediated Mutation
  634. Activation of Nrf2 by Sulforaphane via the AKT/GSK-3β/Fyn pathway prevents angiotensin ii-induced cardiomyopathy
  635. Mechanism of ischemic postconditioning-induced activation of Nrf2-ARE signaling pathway during myocardial ischemia-reperfusion: the relationship with ROS
  636. ATM Mutant Lymphoid Tumour Cells Exhibit Impaired Activation of the Redox-Sensitive Nrf2-ARE Detoxification Pathway and Are Differentially Sensitive to Nrf2 …
  637. The activation mechanism of Nrf2-ARE pathway in protective effect of ischemia and pinacidil postconditioning on isolated rat hearts
  638. 201 Regulation of INOS Function, Redox State and NRF2 Activation by Macrophage GCH1 and Tetrahydrobiopterin
  639. The effects of pyrrolidine dithiocarbamate on the activation of Nrf2 pathway after paraquat induced lung injury in rats
  640. δ-opioid receptor activation increases Nrf2 nuclear translocation and stabilizes mitochondrial membrane potential of hypoxic cells
  641. Project 1: The effect of Nrf2 activators on mesenchymal stem cell viability in response to light curable dimethacrylate resins and Project 2: 3D architectural influences …
  642. An Activator Of AMP Activated Kinase (AMPK) Restores Nrf2 Protein Levels Decreased By Chronic Cigarette Smoke Exposure
  643. Effects of Perilla frutescens on modulations of CYP1A1/2, HO‐1 and activation of Nrf2 in oxidative stress‐induced hepatotoxicity (647.19)
  644. Anti-inflammatory and antioxidant activities of Nrf2/HO-1 activators: in vitro studies in microglia and retinal cells
  645. Nrf2-mediated pentose phosphate pathway activity promotes macrophage inflammasome activation and bacterial killing in microbial sepsis (INM6P. 330)
  646. Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells …
  647. Identification of Chromomoric Acid CI as an Nrf2 Activator in Chromolaena odorata
  648. Identification of the Constituents for Nrf2 Activation and NF-κB Suppression in Dangguisoo-san
  649. Analysis of electrophile-induced Nrf2 gene activation
  650. Treatment with an Nrf2 Activator Ameliorates Acute Pancreatitis in Experimental Animals
  651. Exploring the Protective Effect of Nrf2 Activator On Ischemia Reperfusion Injury in Rat Liver.: Abstract# C2063
  652. … Arthritis Severity in Experimental Arthritis Model Via Reciprocal Regulation of Th17–Regulatory T Cells and Mediating Heme Oxygenase-1 Via NRF2 Activation
  653. Reporter Protein Complementation Imaging Assay to Screen and Study Nrf2 Activators in Cells and Living Animals
  654. Reduced ABCA1 expression and low Nrf2 activation due to
  655. Isolation of natural Nrf2 activators from American ginseng
  656. Modulation of Nrf2-activation by hepatitis B virus
  657. Chamomile (Matricaria chamomilla L.) upregulates heme oxygenase-1 through activation of ERK-Nrf2 signaling: Cytoprotective mechanism against oxidative damage
  658. Zerumbone, a sesquiterpene derived from tropical ginger, induces heme oxygenase-1 expression via activation of Nrf2 signaling in mouse epidermal cells and …
  659. Induction of cytochrome P450 by Nrf2 activators: Implication for aldehyde metabolism
  660. Natural Nrf2 activators protect cells from oxidative damage inflicted by angiotensin II or aldosterone
  661. PREVENTIVE AND/OR THERAPEUTIC EFFECT OF NRF2 ACTIVATORS ON DIABETES-OR ANGIOTENSIN II-INDUCED CARDIOMYOPATHY
  662. Inhibitory regulation of Nrf2 activation by RAC3/AIB1/SRC-3
  663. Nrf2 activation suppresses production of T cell cytokines and IgM in C57BL/6 mice (90.26)
  664. 2116 Activation of nuclear factor (erythroid 2-like)-related factor 2 (NRF2) and NRF-2 dependent genes by ischemic preconditioning and postconditioning: New …
  665. Angiotensin receptor blockade improves antioxidant activity by increasing nrf2 activation during a glucose challenge (693.8)
  666. Nrf2 Activation by Dimercaptopropanol Attenuates Mutant Huntingtin Toxicity
  667. Paradoxical roles of Nrf2 activation in arsenic-induced beta-cell dysfunction
  668. … , 10aS)-10a-ethynyl-4b, 8, 8-trimethyl-3, 7-dioxo-3, 4b, 7, 8, 8a, 9, 10, 10a-octahydro-phenanthrene-2, 6-dicarbonitrile, an activator of the Keap1/Nrf2/ARE pathway, for …
  669. Nrf2 activation by TUDCA in experimental models of Parkinson’s disease
  670. Prophylactic Nrf2 Activation Halts Progression of the Severe Adult Phenotype of Sickle Cell Disease in Transgenic Mice
  671. Nrf2 Activation And The Role Of NADPH Oxidase And Nrf2 In The Production Of Interferon-³ (IFN-³) By Lung Neutrophils During Pneumococcal Pneumonia In Mice
  672. Treatment With the Nrf2 Activator, Dimethyl Fumarate, Ameliorates Liver Ischemia/Reperfusion Injury in Rats.: Abstract# C1658
  673. Targeting NRF2 Activation Modulates X-Ros Signaling in Dystrophic Skeletal Muscle
  674. Nrf2-dependent* ARE activation in neural cells
  675. Inhibition Of Cigarette Smoke-Induced Chemokine Production By The NRF2 Activator Sulforaphane
  676. ROS production is required for follicle-stimulating hormone-induced Nrf2 activation in human epithelial ovarian cancer cells
  677. Dehydroglyasperin C Suppresses NF‐κB‐dependent Inflammation from Acute Lung Injury through Nrf2 Activation in mice
  678. Treatment with the Nrf2 activator, Dimethyl Fumarate, ameliorates acute pancreatitis in a rodent model
  679. Enhanced hepatic Nrf2 activation after ursodeoxycholic acid treatment in patients with primary biliary cirrhosis
  680. Treatment With the Nrf2 Activator, Dimethyl Fumarate, Ameliorates Calcineurin Inhibitor Nephrotoxicity in Rats.: Abstract# A55
  681. Colloidal carbon stimulation of Kupffer cells triggers Nrf2 activation in the isolated perfused rat liver
  682. The Nrf2 activator, tBHQ, inhibits the early production of IL‐2, but not CD69 induction, in primary murine splenocytes and human Jurkat T cells
  683. Sequential phosphorylation by protein kinase CK2 regulates NRF2 activation and degradation: Potential role In arsenic-induced skin carcinogenesis
  684. AAV-mediated activation of the Nrf2 pathway in the Nrf2-deficient mouse
  685. Propofol activation of the Nrf2 pathway is associated with
  686. Upregulation of endogenous antioxidant defenses by Nrf2 activation does not blunt exercise‐induced mitochondrial biogenesis in rats
  687. Activation of Nrf2 by dimethyl fumarate improves vascular calcification
  688. Inhibition of LXR alpha-Dependent Steatosis and Oxidative Injury by Liquiritigenin, a Licorice Flavonoid, as Mediated with Nrf2 Activation (Retracted article. See vol …
  689. Persistent expression of Nqo1 by p62-mediated Nrf2 activation facilitates p53-dependent mitotic catastrophe
  690. The role of aberrant Nrf2/Keap1 pathway activation across a broad spectrum of human cancers.
  691. Activation of Nrf2 skews CD4+ cells toward Th2 differentiation (152.15)
  692. Oral Administration of Compound K Enhances Cognitive Ability of Scopolamine-induced Memory Impaired Mice through Nrf2 Activation
  693. Reduced ABCA1 expression and low Nrf2 activation due to decreased lectin-like oxidized LDL receptor 1 (LOX-1) in the placenta are involved in preeclampsia
  694. Non-Canonical Activation of Nrf2 by Dimercaptopropaenol as a Treatment for Huntington’s Disease
  695. Effects of Monascin on Anti-inflammation Mediated by Nrf2 Activation in Advanced Glycation End Product-Treated THP-1 Monocytes and Methylglyoxal-Treated Wistar …
  696. Multiple sensing mechanism of the Keap1-Nrf2 system for responding to a wide range of activators
  697. Epigenetic activation of miR-200a targets the Nrf2-dependent chemoprevention pathway in breast cancer
  698. DIFFERENTIAL EFFECTS OF THE OXIDIZED METABOLITES OF OLTIPRAZ ON THE ACTIVATION OF C/EBPβ AND NRF2 FOR GSTA2 GENE INDUCTION
  699. Activation Of Nrf2 Attenuates Hypoxia-Induced Cardiopulmonary Alterations In Mice
  700. Impaired activation of Nrf2-ARE signaling pathway: a possible mechanism for Keratoconus
  701. Activation of the NRF2-mediated phase 2 enzyme response as a prophylactic strategy for treatment of stroke and neurodegeneration
  702. RETRACTED: Inhibition of LXRα-dependent steatosis and oxidative injury by liquiritigenin, a licorice flavonoid, as mediated with Nrf2 activation.
  703. Activation of Nrf2 Is Responsible for the Overexpression of Peroxiredoxin and Sulphiredoxin in Smoking Induced Human Lung Cancer.
  704. Biological and Chemical Analysis of Small Molecule Activators of Anti-Inflammatory and Antioxidant Nrf2-Keap1 Signaling
  705. Nrf2 deficiency promotes microgila/macrophage activation after subarachno id hemorrhage in mice
  706. The Synthesis of Tetrahydroquinazolone Derivatives for the Activation of Transcription Factor Nrf2 as Chemoprevention Agents
  707. Lipid oxidation and nitration products as activators of cytoprotective Nrf2 signaling in the endothelium
  708. Activation and Nuclear Translocation of the Transcription Factor Nrf2 by the MAP Kinase Family
  709. Activation of Nrf2 caused by tert-butylbenzoquinone, a metabolite of butylated hydroxyanisole, requires electrophilic modification of Keap1 through its reactive thiols
  710. PAR-2 activation enhances Nrf2 signaling in keratinocytes
  711. Nrf2 transcription factor activation modulates endothelial inflammatory response triggered by TNF-alpha
  712. A62 LUNG FIBROSIS: FIBROBLAST BIOLOGY: Small-Molecule And Peptide Activators Of The Nrf2-Dependent Antioxidant Response Element
  713. Persistent Activation of Nrf2 through p62 in Auditory Cells
  714. Delta-Aminolevulinate Preferentially Induces Gamma-Globin Expression in Erythroid Cells through Activation of NRF2 Stress Response
  715. B34 LUNG MACROPHAGE ACTIVATION IN HEALTH AND DISEASE: Nrf2 And Pu. 1 Are Coordinately Regulated In The Alveolar Macrophage
  716. NRF2 pathway activation and adjuvant chemotherapy benefit in lung squamous cell carcinoma David W. Cescon, Desmond She, 2 Shingo Sakashita, 2, 5 …
  717. Cigarette Smoke Triggers Excessive Complement Activation in Human RPE Cells: Involvement of Nrf2 signaling
  718. Carbocisteine Reduced Influenza Virus-Induced Pulmonary Inflammation Via Activation Of Nrf2 In Cigarette Smoke-Exposed Mice
  719. Low concentration of 4-hydroxy hexenal increases heme oxygenase-1 expression through activation of Nrf2 and antioxidative activity in vascular endothelial …
  720. Abstract A58: Cul3‐mediated Nrf2 ubiquitination and ARE activation are dependent on the partial molar volume at position 151 of Keap1
  721. Methionine sulfoxide reductase A attenuates heme oxygenase-1 induction through inhibition of Nrf2 activation (P1377)
  722. Activation Of The NRF2/ARE Pathway Protects Against Oxidative Stress And Alveolar Epithelial Barrier Dysfunction In HIV-1 Transgenic Rats
  723. Phosphorylation Of Nrf2 By Casein Kinase 2 (CK2) Regulates Activation And Degradation
  724. Liver Specific Knockout Atg5 Causes Persistent Activation of Nrf2 and Protects Against Acetaminophen‐Induced Liver Injury
  725. Activation of Nrf2 Is Required for Up-Regulation of the π Class of Glutathione S-Transferase in Rat Primary Hepatocytes with l-Methionine Starvation
  726. Bruton’s Tyrosine Kinase and Nrf2 mediate TLR-induced activation of Heme oxygenase-1 gene expression in macrophages (116.16)
  727. ISCHAEMIC PRECONDITIONING PROTECTS SKELETAL MUSCLE MYOTUBES AGAINST ISCHAEMIA-REPERFUSION INJURY THROUGH ACTIVATION OF NRF2 …
  728. Genetic Ablation of Nrf2 Enhances Susceptibility to Double-Stranded RNA-or Cigarette Smoke-Induced Activation of NF-κB and IRF-3 in Macrophages.
  729. Activation of NRF2/ABCC1 axis confers resistance to topoisomerase II poisons in human oral malignancies
  730. Resveratrol inhibits oxidative stress and prevents estrogen-induced breast carcinogenesis via activation of NRF2-mediated protective pathways.
  731. Molecular Effects of Baicalein in Hct116 Cells and Caenorhabditis elegans: Activation of the Nrf2 Signaling Pathway and Prolongation of Lifespan
  732. Chlorella Ethanol Extract Induced Phase II Enzyme Through NFE2L2 (Nuclear Factor [Erythroid-Derived] 2-Like 2, NRF2) Activation and Protected Ethanol-Induced …
  733. Nrf2 Inhibits NF-κB Activation During Ischemia Reperfusion Injury and Suppresses Subsequent Development of Cardiac Allograft Vasculopathy in Murine Heart …
  734. Activation of NRF2/ARE Pathway Regulates Hydrogen Peroxide Releasing NADPH Oxidase NOX4 in Endothelial Cells
  735. Neutrophil elastase suppresses cigarette smoke extract‐induced activation of anti‐oxidative pathway by mediating nrf2 degradation in bronchial epithelial cells …
  736. Up-regulation of Nrf2-mediated heme oxygenase-1 expression by eckol, a phlorotannin compound, through activation of Erk and PI3K/Akt
  737. miR‐125b transcriptionally induced by Nrf2 inhibits AhR repressor for AhR activation (663.12)
  738. NRF2 PROTECTS AGAINST ISCHEMIA REPERFUSION INJURY VIA INHIBITION OF NF-κB ACTIVATION AND SUPPRESSES SUBSEQUENT DEVELOPMENT OF …
  739. Correction: Activation of Transcription Factor Nrf2 Signalling by the Sphingosine Kinase Inhibitor SKI-II Is Mediated by the Formation of Keap1 Dimers
  740. Juices of cherry and strawberry confer protection of human bronchial epithelial cells against arsenic-induced toxicity via activation of Nrf2 signaling pathway.
  741. Ethanolic extract of Sargassium serratifolium attenuates inflammatory responses by regulating Nrf2 and NF-B activation in lipopolysaccharide-stimulated RAW 264.7 …
  742. The Oxidant Response Transcription Factor NRF2 Mediates Heme Activation of Placenta Growth Factor Expression in Erythroid Cells, a Contributor to …
  743. PAR-2 activation enhances Nrf2 signaling in keratinocytes: Is it associated with the pathogenesis of vitiligo?
  744. A small-molecule activator of Hsf1, Nrf1, and Nrf2 mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy models (S34. 006)
  745. Amyloid-Beta Induced Neurotoxicity Is Attenuated by Partridge Berry Polyphenols through Bcl-2/Bcl-XL and Keap1-Nrf2 Activation
  746. Research Article Cordyceps sinensis Increases Hypoxia Tolerance by Inducing Heme Oxygenase-1 and Metallothionein via Nrf2 Activation in Human Lung …
  747. Auranofin, a gold (1)-containing antirheumatic compound, activates Keap1/Nrf2 signaling via Rac1/iNOS signal and mitogen-activated protein kinase activation
  748. Pharmacologic and transgenic activation of nuclear factor-erythroid 2-related factor 2 (Nrf2) alters kinetics and toxicodynamics of xenobiotics
  749. Free Paper Presentation: OS-64; Macroautophagy Activation via Nrf2-Dependent Up-Regulation of LC3B Limits Proteasome Inhibitor (PI)-Induced Lung Cancer Cell …
  750. Sulforaphane suppresses 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse epidermal JB6 P+ cell transformation through epigenetic re-activation of Nrf2.
  751. 5.1 Nrf2 transcriptional activity controls Nlrp3 inflammasome activation independent of reactive oxygen species levels
  752. D33 AIRWAY EPITHELIA ACTIVATION AND RESPONSES TO TREATMENT: Nuclear Factor, Erythroid Derived 2, Like 2 (nrf2) Regulates Airway Epithelial Barrier …
  753. Sulfuraphane (SFN) activation of nuclear factor E2‐related factor 2 (Nrf2) increases expression and transport activity of P‐glycoprotein (P‐gp) and breast cancer …
  754. … Korean Academy of Tuberculosis and Respiratory Diseases: Slide Session; OS-064: Lung Cancer; Macroautophagy Activation via Nrf2-Dependent Up-Regulation of …
  755. Heme Oxygenase-1 via Transcriptional Activation of Nrf2 Attenuates Apoptosis in Lung Cancer Cells
  756. Canonical and non-canonical mechanisms of Nrf2 activation
  757. NRF2 activation in cancer: from DNA to protein
  758. Activators and inhibitors of NRF2: a review of their potential for clinical development
  759. Naturally occurring Nrf2 activators: potential in treatment of liver injury
  760. Role of Nrf2 and its activators in respiratory diseases
  761. Nrf2 activator for the treatment of kidney diseases
  762. NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis
  763. Preventive and protective roles of dietary Nrf2 activators against central nervous system diseases
  764. Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function
  765. Repurposing the NRF2 activator dimethyl fumarate as therapy against synucleinopathy in Parkinson’s disease
  766. Sulforaphane and other nutrigenomic Nrf2 activators: can the clinician’s expectation be matched by the reality?
  767. Nrf2 activation drive macrophages polarization and cancer cell epithelial-mesenchymal transition during interaction
  768. Resveratrol, an Nrf2 activator, ameliorates aging-related progressive renal injury
  769. Nrf2 activation promotes lung cancer metastasis by inhibiting the degradation of Bach1
  770. Therapeutic effects of Nrf2 activation by bardoxolone methyl in chronic heart failure
  771. Pterostilbene-mediated Nrf2 activation: Mechanistic insights on Keap1: Nrf2 interface
  772. Recent advances in understanding NRF2 as a druggable target: development of pro-electrophilic and non-covalent NRF2 activators to overcome systemic …
  773. Nrf2 activation is a potential therapeutic approach to attenuate diabetic retinopathy
  774. Activation of Nrf2 signaling by natural products-can it alleviate diabetes?
  775. Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson’s disease
  776. Control of oxidative stress and inflammation in sickle cell disease with the Nrf2 activator dimethyl fumarate
  777. Hydrogen sulfide induces Keap1 S-sulfhydration and suppresses diabetes-accelerated atherosclerosis via Nrf2 activation
  778. Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates
  779. Nrf2 activators as potential modulators of injury in human kidney cells
  780. Suppressed ubiquitination of Nrf2 by p47phox contributes to Nrf2 activation
  781. Identification of non-electrophilic Nrf2 activators from approved drugs
  782. C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape
  783. Nrf2 mutagenic activation drives hepatocarcinogenesis
  784. ROS-independent Nrf2 activation in prostate cancer
  785. The role of Nrf2 in NLRP3 inflammasome activation
  786. A dual AMPK/Nrf2 activator reduces brain inflammation after stroke by enhancing microglia M2 polarization
  787. Recent advances of natural polyphenols activators for Keap1‐Nrf2 signaling pathway
  788. The effect of dietary supplementation with curcumin on redox status and Nrf2 activation in patients with nondiabetic or diabetic proteinuric chronic kidney disease: a …
  789. Design, synthesis, and evaluation of curcumin derivatives as Nrf2 activators and cytoprotectors against oxidative death
  790. Differential effects of the Nrf2 activators tBHQ and CDDO-Im on the early events of T cell activation
  791. Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation
  792. NRF2 activation impairs quiescence and bone marrow reconstitution capacity of hematopoietic stem cells
  793. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis
  794. Lutein prevents osteoarthritis through Nrf2 activation and downregulation of inflammation
  795. … /nanoparticulate powders of a novel Nrf2 activator and an aerosol performance enhancer for pulmonary delivery targeting the lung Nrf2/Keap-1 pathway
  796. Nrf2 activation provides atheroprotection in diabetic mice through concerted upregulation of antioxidant, anti-inflammatory, and autophagy mechanisms
  797. High CD44 expression mediates p62-associated NFE2L2/NRF2 activation in breast cancer stem cell-like cells: Implications for cancer stem cell resistance
  798. The Nrf2 activator tBHQ inhibits the activation of primary murine natural killer cells
  799. Pro-fibrotic compounds induce stellate cell activation, ECM-remodelling and Nrf2 activation in a human 3D-multicellular model of liver fibrosis
  800. Nrf2‐lncRNA controls cell fate by modulating p53‐dependent Nrf2 activation as an miRNA sponge for Plk2 and p21cip1
  801. Anti-neuroinflammatory effect of emodin in LPS-stimulated microglia: involvement of AMPK/Nrf2 activation
  802. Nrf2 activation attenuates genetic endoplasmic reticulum stress induced by a mutation in the phosphomannomutase 2 gene in zebrafish
  803. Systemic activation of NRF2 alleviates lethal autoimmune inflammation in scurfy mice
  804. Circadian control of BDNF-mediated Nrf2 activation in astrocytes protects dopaminergic neurons from ferroptosis
  805. Nrf2 activation in osteoblasts suppresses osteoclastogenesis via inhibiting IL-6 expression.
  806. Transient acceleration of autophagic degradation by pharmacological Nrf2 activation is important for retinal pigment epithelium cell survival
  807. Broccoli sprout extract prevents diabetic cardiomyopathy via Nrf2 activation in db/db T2DM mice
  808. Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding
  809. Elevating CXCR7 improves angiogenic function of EPCs via Akt/GSK-3β/Fyn-mediated Nrf2 activation in diabetic limb ischemia
  810. Oxidative damage control in a human (mini-) organ: Nrf2 activation protects against oxidative stress-induced hair growth inhibition
  811. Astaxanthin suppresses cigarette smoke-induced emphysema through Nrf2 activation in mice
  812. Liver injury attenuation by curcumin in a rat NASH model: an Nrf2 activation-mediated effect?
  813. Lutein suppresses oxidative stress and inflammation by Nrf2 activation in an osteoporosis rat model
  814. Tanshinone IIA attenuates contrast-induced nephropathy via Nrf2 activation in rats
  815. Methane ameliorates spinal cord ischemia-reperfusion injury in rats: antioxidant, anti-inflammatory and anti-apoptotic activity mediated by Nrf2 activation
  816. … underlying the beneficial effects of hydroxytyrosol in the pathogenic alterations induced by a high-fat diet in mouse liver: PPAR-α and Nrf2 activation, and NF-κB down …
  817. Non-covalent NRF2 activation confers greater cellular protection than covalent activation
  818. Are astrocytes the predominant cell type for activation of Nrf2 in aging and neurodegeneration?
  819. ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells
  820. Nrf2 activator RTA-408 protects against ozone-induced acute asthma exacerbation by suppressing ROS and γδT17 cells
  821. … -induced adhesion molecule expression and oxidant production in human aortic endothelial cells by p38-mediated Nrf2 activation and antioxidant enzyme …
  822. Diverse Nrf2 activators coordinated to cobalt carbonyls induce heme oxygenase-1 and release carbon monoxide in vitro and in vivo
  823. Nrf2 activation protects mouse beta cells from glucolipotoxicity by restoring mitochondrial function and physiological redox balance
  824. Chemical activation of the constitutive androstane receptor leads to activation of oxidant-induced Nrf2
  825. Non-canonical activation of NRF2: New insights and its relevance to disease
  826. Collaborative Power of Nrf2 and PPARγ Activators against Metabolic and Drug-Induced Oxidative Injury
  827. Activation of the p62‐Keap1‐NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells
  828. Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer
  829. Lycopene relieves AFB1-induced liver injury through enhancing hepatic antioxidation and detoxification potential with Nrf2 activation
  830. Carnosol as a Nrf2 activator improves endothelial barrier function through antioxidative mechanisms
  831. Cytoprotective effects of a novel Nrf2 activator, RS9, in rhodopsin Pro347Leu rabbits
  832. A proof-of-concept clinical study examining the NRF2 activator sulforaphane against neutrophilic airway inflammation
  833. Myricetin ameliorates brain injury and neurological deficits via Nrf2 activation after experimental stroke in middle-aged rats
  834. Nrf2 activator RS9 suppresses pathological ocular angiogenesis and hyperpermeability
  835. Chronic oxidative stress, mitochondrial dysfunction, Nrf2 activation and inflammation in the hippocampus accompany heightened systemic inflammation and …
  836. Antioxidant and pro-angiogenic effects of corilagin in rat cerebral ischemia via Nrf2 activation
  837. An overview of the advantages of KEAP1-NRF2 system activation during inflammatory disease treatment
  838. Nrf2 activators from Glycyrrhiza inflata and their hepatoprotective activities against CCl4-induced liver injury in mice
  839. Targeted Nrf2 activation therapy with RTA 408 enhances regenerative capacity of diabetic wounds
  840. Brain ischemic preconditioning protects against ischemic injury and preserves the blood-brain barrier via oxidative signaling and Nrf2 activation
  841. HDAC3 inhibition prevents blood-brain barrier permeability through Nrf2 activation in type 2 diabetes male mice
  842. A novel Nrf2 activator, RS9, attenuates secondary brain injury after intracerebral hemorrhage in sub-acute phase
  843. The NRF2 activator DH404 attenuates adverse ventricular remodeling post-myocardial infarction by modifying redox signalling
  844. Rosmarinic acid attenuates β-amyloid-induced oxidative stress via Akt/GSK-3β/Fyn-mediated Nrf2 activation in PC12 cells
  845. Fucoxanthin elicits epigenetic modifications, Nrf2 activation and blocking transformation in mouse skin JB6 P+ cells
  846. Inhibiting inflammation and modulating oxidative stress in oxalate-induced nephrolithiasis with the Nrf2 activator dimethyl fumarate
  847. Valproic acid sensitizes hepatocellular carcinoma cells to proton therapy by suppressing NRF2 activation
  848. Isoalantolactone protects LPS-induced acute lung injury through Nrf2 activation
  849. Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury
  850. Artesunate protects LPS-induced acute lung injury by inhibiting TLR4 expression and inducing Nrf2 activation
  851. Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity
  852. A solid dispersion of quercetin shows enhanced Nrf2 activation and protective effects against oxidative injury in a mouse model of dry age-related macular …
  853. Zedoarondiol attenuates endothelial cells injury induced by oxidized low-density lipoprotein via Nrf2 activation
  854. Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury
  855. Antioxidant, anti-inflammatory, and neuroprotective effects of novel vinyl sulfonate compounds as nrf2 activator
  856. Nrf2 activation attenuates the early suppression of mitochondrial respiration due to the α-synuclein overexpression
  857. Nrf2 activation protects against intratracheal LPS induced mouse/murine acute respiratory distress syndrome by regulating macrophage polarization
  858. Nrf2 activator ameliorates hemorrhagic transformation in focal cerebral ischemia under warfarin anticoagulation
  859. Activation of the astrocytic Nrf2/ARE system ameliorates the formation of demyelinating lesions in a multiple sclerosis animal model
  860. Identification of novel Nrf2 activators from Cinnamomum chartophyllum HW Li and their potential application of preventing oxidative insults in human lung …
  861. Oregano essential oil induces SOD1 and GSH expression through Nrf2 activation and alleviates hydrogen peroxide-induced oxidative damage in IPEC-J2 …
  862. Nrf2 activation by 5-lipoxygenase metabolites in human umbilical vascular endothelial cells
  863. A small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy
  864. HYCO-3, a dual CO-releaser/Nrf2 activator, reduces tissue inflammation in mice challenged with lipopolysaccharide
  865. Inhibition of Nrf2/HO-1 signaling leads to increased activation of the NLRP3 inflammasome in osteoarthritis
  866. Xanthohumol analogues as potent Nrf2 activators against oxidative stress mediated damages of PC12 cells
  867. Nrf2 activation induced by Sirt1 ameliorates acute lung injury after intestinal ischemia/reperfusion through NOX4-mediated gene regulation
  868. Experimental nonalcoholic steatohepatitis and liver fibrosis are ameliorated by pharmacologic activation of Nrf2 (NF-E2 p45-related factor 2)
  869. Activation of anti-oxidant Nrf2 signaling by enone analogues of curcumin
  870. Brg1-mediated Nrf2/HO-1 pathway activation alleviates hepatic ischemia–reperfusion injury
  871. Activation of the Nrf2 cell defense pathway by ancient foods: disease prevention by important molecules and microbes lost from the modern western diet
  872. Inhibition of neuroinflammation by thymoquinone requires activation of Nrf2/ARE signalling
  873. Influence of Nrf2 activators on subcellular skeletal muscle protein and DNA synthesis rates after 6 weeks of milk protein feeding in older adults
  874. Activation of Nrf2/HO-1 pathway by nardochinoid C inhibits inflammation and oxidative stress in lipopolysaccharide-stimulated macrophages
  875. … persulfides and polysulfides produced by exchange reactions with H2S protect SH-SY5Y cells from methylglyoxal-induced toxicity through Nrf2 activation
  876. Nrf2 activation as a key event triggered by skin sensitisers: The development of the stable KeratinoSens reporter gene assay
  877. … inhibits platelet-derived growth factor-induced vascular smooth muscle cell proliferation by targeting mTOR/p70S6kinase signaling independent of Nrf2 activation
  878. Grape seed procyanidin extract ameliorates lead-induced liver injury via miRNA153 and AKT/GSK-3β/Fyn-mediated Nrf2 activation
  879. Skin redox balance maintenance: the need for an Nrf2-activator delivery system
  880. Nrf2 activation is required for curcumin to induce lipocyte phenotype in hepatic stellate cells
  881. Xiaochaihutang attenuates liver fibrosis by activation of Nrf2 pathway in rats
  882. Maggot extracts alleviate inflammation and oxidative stress in acute experimental colitis via the activation of Nrf2
  883. A systematic analysis of Nrf2 pathway activation dynamics during repeated xenobiotic exposure
  884. Structure-activity and structure-property relationships of novel Nrf2 activators with a 1, 2, 4-oxadiazole core and their therapeutic effects on acetaminophen (APAP) …
  885. Lipoic acid prevents high-fat diet-induced hepatic steatosis in Goto Kakizaki rats by reducing oxidative stress through Nrf2 activation
  886. A potent Nrf2 activator, dh404, bolsters antioxidant capacity in glial cells and attenuates ischaemic retinopathy
  887. Ketone body 3‐hydroxybutyrate mimics calorie restriction via the Nrf2 activator, fumarate, in the retina
  888. Antioxidant and hepatoprotective effect of polyphenols from apple pomace extract via apoptosis inhibition and Nrf2 activation in mice
  889. Activation of Nrf2 might reduce oxidative stress in human granulosa cells
  890. Nrf2/ARE pathway inhibits ROS-induced NLRP3 inflammasome activation in BV2 cells after cerebral ischemia reperfusion
  891. Anti-inflammatory effects of astroglial α7 nicotinic acetylcholine receptors are mediated by inhibition of the NF-κB pathway and activation of the Nrf2 pathway
  892. l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway
  893. Prodigiosin promotes Nrf2 activation to inhibit oxidative stress induced by microcystin-LR in HepG2 cells
  894. Schisantherin A attenuates neuroinflammation in activated microglia: role of Nrf2 activation through ERK phosphorylation
  895. Neuroprotective effect of Nrf2 activator dimethyl fumarate, on the hippocampal neurons in chemical kindling model in rat
  896. Nrf2 activation by SK-119 attenuates oxidative stress, UVB, and LPS-induced damage
  897. RPA1 binding to NRF2 switches ARE-dependent transcriptional activation to ARE-NRE–dependent repression
  898. Flazin as a promising Nrf2 pathway activator
  899. Protective activity of tovophyllin A, a xanthone isolated from Garcinia mangostana pericarps, against acetaminophen-induced liver damage: role of Nrf2 activation
  900. … rat offspring against hypertension programmed by prenatal dexamethasone administration and postnatal high-fat diet with the Nrf2 activator dimethyl fumarate during …
  901. Sulforaphane protects from myocardial ischemia-reperfusion damage through the balanced activation of Nrf2/AhR
  902. Mesenchymal stromal cell-derived extracellular vesicles protect against acute kidney injury through anti-oxidation by enhancing Nrf2/ARE activation in rats
  903. … Isolated from Pogostemon cablin Bentham Exerts Antioxidant and Cytoprotective Effects in HepG2 Cells: Possible Role of ERK-Dependent Nrf2 Activation
  904. Honokiol alleviates oxidative stress-induced neurotoxicity via activation of Nrf2
  905. Schisandrol B protects against acetaminophen-induced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathway
  906. Nrf2 activator, sulforaphane ameliorates autism-like symptoms through suppression of Th17 related signaling and rectification of oxidant-antioxidant imbalance in …
  907. Short-term pharmacological activation of Nrf2 ameliorates vascular dysfunction in aged rats and in pathological human vasculature. A potential target for …
  908. Activation of Nrf2-antioxidant signaling by 1, 25-dihydroxycholecalciferol prevents leptin-induced oxidative stress and inflammation in human endothelial cells
  909. 1, 25‐Dihydroxyvitamin D exerts an antiaging role by activation of Nrf2‐antioxidant signaling and inactivation of p16/p53‐senescence signaling
  910. NRF2 activation inhibits both TGF-β1-and IL-13-mediated periostin expression in fibroblasts: Benefit of cinnamaldehyde for antifibrotic treatment
  911. Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt/GSK-3ß/Fyn pathway
  912. Asiatic acid enhances Nrf2 signaling to protect HepG2 cells from oxidative damage through Akt and ERK activation
  913. Constitutive activation of Nrf2 induces a stable reductive state in the mouse myocardium
  914. Simultaneous activation of Nrf2 and elevation of antioxidant compounds for reducing oxidative stress and chronic inflammation in human Alzheimer’s disease
  915. Copper diethyldithiocarbamate as an activator of Nrf2 in cultured vascular endothelial cells
  916. Reversal of cigarette smoke extract‐induced sinonasal epithelial cell barrier dysfunction through Nrf2 Activation
  917. Activation of Nrf2 by the dengue virus causes an increase in CLEC5A, which enhances TNF-α production by mononuclear phagocytes
  918. The hepatoprotective effects of Sedum sarmentosum extract and its isolated major constituent through Nrf2 activation and NF-κB inhibition
  919. Rice protein suppresses ROS generation and stimulates antioxidant gene expression via Nrf2 activation in adult rats
  920. PFOS induces adipogenesis and glucose uptake in association with activation of Nrf2 signaling pathway
  921. The protective effects of isoliquiritigenin and glycyrrhetinic acid against triptolide-induced oxidative stress in HepG2 cells involve Nrf2 activation
  922. Evidence of activation of the Nrf2 pathway in multiple sclerosis patients treated with delayed-release dimethyl fumarate in the Phase 3 DEFINE and CONFIRM studies
  923. Astragalus membranaceus Extract Attenuates Inflammation and Oxidative Stress in Intestinal Epithelial Cells via NF-κB Activation and Nrf2 Response
  924. Can co-activation of Nrf2 and neurotrophic signaling pathway slow Alzheimer’s disease?
  925. … sativus) intake provides nutritional preconditioning against myocardial ischemia–reperfusion injury in Wild Type and ApoE (−/−) mice: Involvement of Nrf2 activation
  926. Nrf2 protects stellate cells from Smad-dependent cell activation
  927. Neuroprotective effect of an Nrf2-ARE activator identified from a chemical library on dopaminergic neurons
  928. Diabetic wound healing and activation of Nrf2 by herbal medicine
  929. Activation of Nrf2 in the liver is associated with stress resistance mediated by suppression of the growth hormone-regulated STAT5b transcription factor
  930. Antioxidant and antihypertensive responses to oral nitrite involves activation of the Nrf2 pathway
  931. … -induced oxidative stress and inflammation in human umbilical vein endothelial cells through suppression of mitochondrial dysfunction and activation of Nrf2
  932. … , a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation
  933. Farrerol ameliorates APAP-induced hepatotoxicity via activation of Nrf2 and autophagy
  934. Evaluation of the rotenone-induced activation of the Nrf2 pathway in a neuronal model derived from human induced pluripotent stem cells
  935. Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in …
  936. Simvastatin induces heme oxygenase-1 via NF-E2-related factor 2 (Nrf2) activation through ERK and PI3K/Akt pathway in colon cancer
  937. Activation of Nrf2 by costunolide provides neuroprotective effect in PC12 cells
  938. NRF2 through RPS6 Activation Is Related to Anti-HER2 Drug Resistance in HER2-Amplified Gastric Cancer
  939. Nrf2 activation is required for ligustrazine to inhibit hepatic steatosis in alcohol-preferring mice and hepatocytes
  940. Fenofibrate ameliorates diabetic retinopathy by modulating Nrf2 signaling and NLRP3 inflammasome activation
  941. Dihydromyricetin relieves rheumatoid arthritis symptoms and suppresses expression of pro-inflammatory cytokines via the activation of Nrf2 pathway in rheumatoid …
  942. Activation of Nrf2 pathway contributes to neuroprotection by the dietary flavonoid tiliroside
  943. Melatonin attenuates LPS-induced acute depressive-like behaviors and microglial NLRP3 inflammasome activation through the SIRT1/Nrf2 pathway
  944. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activator dh404 protects against diabetes-induced endothelial dysfunction
  945. Nrf2 activation in myeloid cells and endothelial cells differentially mitigates sickle cell disease pathology in mice
  946. Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults
  947. Comprehensive landscape of Nrf2 and p53 pathway activation dynamics by oxidative stress and DNA damage
  948. Niga-ichigoside F1 ameliorates high-fat diet-induced hepatic steatosis in male mice by Nrf2 activation
  949. Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet
  950. GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway
  951. Activation of Nrf2/HO-1 pathway and human atherosclerotic plaque vulnerability: an in vitro and in vivo study
  952. Activation of Nrf2-driven antioxidant enzymes by cardamonin confers neuroprotection of PC12 cells against oxidative damage
  953. Activation of Nrf2 by Ginsenoside Rh3 protects retinal pigment epithelium cells and retinal ganglion cells from UV
  954. Oxidative stress in metabolic disorders and drug-induced injury: the potential role of Nrf2 and PPARs activators
  955. Osteocalcin improves nonalcoholic fatty liver disease in mice through activation of Nrf2 and inhibition of JNK
  956. Curcumin ameliorates dopaminergic neuronal oxidative damage via activation of the Akt/Nrf2 pathway
  957. Melatonin receptor activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathway
  958. Protective effects of sulforaphane on diabetic retinopathy: activation of the Nrf2 pathway and inhibition of NLRP3 inflammasome formation
  959. Lactucopicrin ameliorates oxidative stress mediated by scopolamine-induced neurotoxicity through activation of the NRF2 pathway
  960. Primary cilium-autophagy-Nrf2 (PAN) axis activation commits human embryonic stem cells to a neuroectoderm fate
  961. RS 9, a novel Nrf2 activator, attenuates light‐induced death of cells of photoreceptor cells and Müller glia cells
  962. Sesamin enhances Nrf2-mediated protective defense against oxidative stress and inflammation in colitis via AKT and ERK activation
  963. Effects of acute hypoxia exposure with different durations on activation of Nrf2-ARE pathway in mouse skeletal muscle
  964. Activation of the KEAP1‑NRF2‑ARE signaling pathway reduces oxidative stress in Hep2 cells
  965. Molecular similarity guided optimization of novel Nrf2 activators with 1, 2, 4-oxadiazole core
  966. Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activator NRF2
  967. Sirtuin 6 protects the brain from cerebral ischemia/reperfusion injury through NRF2 activation
  968. Activation of KGFR-Akt-mTOR-Nrf2 signaling protects human retinal pigment epithelium cells from Ultra-violet
  969. Activation of Nrf2 signaling augments vesicular stomatitis virus oncolysis via autophagy-driven suppression of antiviral immunity
  970. Impact of glucoraphanin-mediated activation of Nrf2 on non-alcoholic fatty liver disease with a focus on mitochondrial dysfunction
  971. Dietary luteolin protects against HgCl2-induced renal injury via activation of Nrf2-mediated signaling in rat
  972. Sinomenine activation of Nrf2 signaling prevents hyperactive inflammation and kidney injury in a mouse model of obstructive nephropathy
  973. Compound analysis of jing liqueur and Nrf2 activation by jing liqueur—One of the most popular beverages in China
  974. Phenethyl isothiocyanate, a dual activator of transcription factors NRF2 and HSF1
  975. Activation of the Nrf2-ARE pathway by the Alternaria alternata mycotoxins altertoxin I and II
  976. Reversing ROS‐mediated neurotoxicity by chlorogenic acid involves its direct antioxidant activity and activation of Nrf2‐ARE signaling pathway
  977. Babao Dan attenuates acute ethanol-induced liver injury via Nrf2 activation and autophagy
  978. Dimethyl fumarate ameliorates dextran sulfate sodium-induced murine experimental colitis by activating Nrf2 and suppressing NLRP3 inflammasome activation
  979. Activation of NRF2/ARE by isosilybin alleviates Aβ25-35-induced oxidative stress injury in HT-22 cells
  980. 6-O-Galloylpaeoniflorin attenuates cerebral ischemia reperfusion-induced neuroinflammation and oxidative stress via PI3K/Akt/Nrf2 activation
  981. Baicalein protects human vitiligo melanocytes from oxidative stress through activation of NF-E2-related factor2 (Nrf2) signaling pathway
  982. A novel role of topical iodine in skin: Activation of the Nrf2 pathway
  983. … brain injury after experimental intracerebral hemorrhage via suppressing ROS-and/or NF-κB-mediated NLRP3 inflammasome activation by promoting Nrf2 …
  984. Lycopene ameliorates oxidative stress in the aging chicken ovary via activation of Nrf2/HO-1 pathway
  985. Cardioprotective role of azafrin in against myocardial injury in rats via activation of the Nrf2-ARE pathway
  986. Curcumin attenuates lipopolysaccharide/d-galactosamine-induced acute liver injury by activating Nrf2 nuclear translocation and inhibiting NF-kB activation
  987. Activation of AKT pathway by Nrf2/PDGFA feedback loop contributes to HCC progression
  988. A novel Nrf2 activator from microbial transformation inhibits radiation-induced dermatitis in mice
  989. Activation of AMPK/Nrf2 signalling by Manuka honey protects human dermal fibroblasts against oxidative damage by improving antioxidant response and …
  990. Leonurine ameliorates D-galactose-induced aging in mice through activation of the Nrf2 signalling pathway
  991. KEAP1 editing using CRISPR/Cas9 for therapeutic NRF2 activation in primary human T lymphocytes
  992. Neuroprotective role of fucoxanthin against cerebral ischemic/reperfusion injury through activation of Nrf2/HO-1 signaling
  993. Ethanol-mediated stress promotes autophagic survival and aggressiveness of colon cancer cells via activation of Nrf2/HO-1 pathway
  994. Isoorientin ameliorates APAP-induced hepatotoxicity via activation Nrf2 antioxidative pathway: The involvement of AMPK/Akt/GSK3β
  995. Activation of Nrf2 signaling by sitagliptin and quercetin combination against β‐amyloid induced Alzheimer’s disease in rats
  996. … effects of novel derivatives of vitamin D3 and lumisterol against UVB-induced damage in human keratinocytes involve activation of Nrf2 and p53 defense …
  997. Tussilagonone-induced Nrf2 pathway activation protects HepG2 cells from oxidative injury
  998. KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo
  999. Sodium butyrate attenuates diabetes-induced aortic endothelial dysfunction via P300-mediated transcriptional activation of Nrf2
  1000. Protection against HEMA-Induced Mitochondrial Injury In Vitro by Nrf2 Activation
  1001. Activation of the Nrf2 signaling pathway in usnic acid-induced toxicity in HepG2 cells
  1002. Resveratrol attenuates testicular apoptosis in type 1 diabetic mice: Role of Akt-mediated Nrf2 activation and p62-dependent Keap1 degradation
  1003. … mitochondrial dysfunction and oxidative stress in chicken (Gallus gallus) kidney via mitochondrial UPR inhibition and Nrf2-mediated antioxidant defense activation
  1004. Optimization of vinyl sulfone derivatives as potent nuclear factor erythroid 2-related factor 2 (Nrf2) activators for Parkinson’s disease therapy
  1005. Ferulic acid protects against methotrexate nephrotoxicity via activation of Nrf2/ARE/HO-1 signaling and PPARγ, and suppression of NF-κB/NLRP3 inflammasome axis
  1006. Naringenin reduces oxidative stress and improves mitochondrial dysfunction via activation of the Nrf2/ARE signaling pathway in neurons
  1007. The natural flavone acacetin confers cardiomyocyte protection against hypoxia/reoxygenation injury via AMPK-mediated activation of Nrf2 signaling pathway
  1008. Fluid shear stress stimulates MATE2-K expression via Nrf2 pathway activation
  1009. Activation of KEAP1/NRF2/P62 signaling alleviates high phosphate-induced calcification of vascular smooth muscle cells by suppressing reactive oxygen …
  1010. Air pollutant–mediated disruption of sinonasal epithelial cell barrier function is reversed by activation of the Nrf2 pathway
  1011. Paeonol ameliorates diabetic renal fibrosis through promoting the activation of the Nrf2/ARE pathway via up-regulating Sirt1
  1012. Cell-specific activation of the Nrf2 antioxidant pathway increases mucosal inflammation in acute but not in chronic colitis
  1013. Calcitriol inhibits ROS-NLRP3-IL-1β signaling axis via activation of Nrf2-antioxidant signaling in hyperosmotic stress stimulated human corneal epithelial cells
  1014. L-F001, a novel multifunctional ROCK inhibitor, suppresses neuroinflammation in vitro and in vivo: Involvement of NF-κB inhibition and Nrf2 pathway activation
  1015. … antiphotoaging and dermatoprotective properties in ultraviolet A-irradiated human skin fibroblast cells via the activation of Nrf2/ARE defensive pathway
  1016. Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway
  1017. ERK/Nrf2 pathway activation by caffeic acid in HepG2 cells alleviates its hepatocellular damage caused by t-butylhydroperoxide-induced oxidative stress
  1018. The Nrf2 activator vinylsulfone reduces high glucose-induced neural tube defects by suppressing cellular stress and apoptosis
  1019. A novel nuclear factor erythroid 2-related factor 2 (Nrf2) activator RS9 attenuates brain injury after ischemia reperfusion in mice
  1020. Melatonin attenuates acute kidney ischemia/reperfusion injury in diabetic rats by activation of the SIRT1/Nrf2/HO-1 signaling pathway
  1021. Activation of Nrf2 attenuates carbonyl stress induced by methylglyoxal in human neuroblastoma cells: Increase in GSH levels is a critical event for the detoxification …
  1022. … ameliorates lipopolysaccharide-induced acute lung injury in mice by suppressing oxidative stress and inflammation via the activation of the Nrf2-mediated HO-1 …
  1023. Activation of Nrf2/ARE pathway alleviates the cognitive deficits in PS1V97L‐Tg mouse model of Alzheimer’s disease through modulation of oxidative stress
  1024. Luteolin ameliorates dextran sulfate sodium-induced colitis in mice possibly through activation of the Nrf2 signaling pathway
  1025. Mechanism of isoniazid-induced hepatotoxicity in zebrafish larvae: activation of ROS-mediated ERS, apoptosis and the Nrf2 pathway
  1026. Pharmacological activation of the Nrf2 pathway by 3H-1, 2-dithiole-3-thione is neuroprotective in a mouse model of Alzheimer disease
  1027. HIV-Tat induces the Nrf2/ARE pathway through NMDA receptor-elicited spermine oxidase activation in human neuroblastoma cells
  1028. Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program
  1029. A novel compound AB-38b improves diabetes-associated cognitive decline in mice via activation of Nrf2/ARE pathway
  1030. Hydrogen sulfide ameliorates learning memory impairment in APP/PS1 transgenic mice: a novel mechanism mediated by the activation of Nrf2
  1031. Activation of GSK3β/β-TrCP axis via PHLPP1 exacerbates Nrf2 degradation leading to impairment in cell survival pathway during diabetic nephropathy
  1032. Inhibition of PRMT5 attenuates oxidative stress-induced pyroptosis via activation of the Nrf2/HO-1 signal pathway in a mouse model of renal ischemia …
  1033. Nrf2 activation and down-regulation of HMGB1 and MyD88 expression by amnion membrane extracts in response to the hypoxia-induced injury in cardiac …
  1034. Activation of the NRF2-ARE signalling pathway by the Lentinula edodes polysaccharose LNT alleviates ROS-mediated cisplatin nephrotoxicity
  1035. Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors
  1036. SIRT6 protects vascular endothelial cells from angiotensin II-induced apoptosis and oxidative stress by promoting the activation of Nrf2/ARE signaling
  1037. A ROS-mediated mitochondrial pathway and Nrf2 pathway activation are involved in BDE-47 induced apoptosis in Neuro-2a cells
  1038. Bisdemethoxycurcumin protection of cardiomyocyte mainly depends on Nrf2/HO-1 activation mediated by the PI3K/AKT pathway
  1039. Sulforaphane prevents testicular damage in Kunming mice exposed to cadmium via activation of Nrf2/ARE signaling pathways
  1040. Activation of Nrf2 is required for normal and ChREBPα-augmented glucose-stimulated β-cell proliferation
  1041. Nrf2 activation as a protective feedback to limit cell death in high glucose‐exposed cardiomyocytes
  1042. Yellow Wine Polyphenolic Compounds prevents Doxorubicin‐induced cardiotoxicity through activation of the Nrf2 signalling pathway
  1043. … endothelial cells against oxygen-glucose deprivation/reperfusion-induced barrier dysfunction via activation of PI3K/Akt/Nrf2 antioxidant signaling pathway
  1044. … A protects lipopolysaccharide/D-galactosamine-induced acute liver injury in mice by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation
  1045. Activation of c-Met in cancer cells mediates growth-promoting signals against oxidative stress through Nrf2-HO-1
  1046. Activation of cannabinoid receptor type II by AM1241 ameliorates myocardial fibrosis via Nrf2-mediated inhibition of TGF-β1/Smad3 pathway in myocardial …
  1047. NRF2/HO-1 activation via ERK pathway involved in the anti-neuroinflammatory effect of Astragaloside IV in LPS induced microglial cells
  1048. Ginnalin A from Kujin tea (Acer tataricum subsp. ginnala) exhibits a colorectal cancer chemoprevention effect via activation of the Nrf2/HO-1 signaling pathway
  1049. Ginsenoside Rb1 attenuates intestinal ischemia/reperfusion‑induced inflammation and oxidative stress via activation of the PI3K/Akt/Nrf2 signaling pathway
  1050. Hydrogen sulfide attenuates calcification of vascular smooth muscle cells via KEAP1/NRF2/NQO1 activation
  1051. Antioxidant properties of 5-hydroxy-4-phenyl-butenolide via activation of Nrf2/ARE signaling pathway
  1052. A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system
  1053. … functions of a cytoprotective effect and apoptosis induction by bioavailable marine carotenoid fucoxanthinol through modulation of the Nrf2 activation in RAW264. 7 …
  1054. Deletion of Nrf2 leads to hepatic insulin resistance via the activation of NF-κB in mice fed a high-fat diet
  1055. Melatonin alleviates aluminium chloride-induced immunotoxicity by inhibiting oxidative stress and apoptosis associated with the activation of Nrf2 signaling pathway
  1056. Curcumin attenuates heat-stress-induced oxidant damage by simultaneous activation of GSH-related antioxidant enzymes and Nrf2-mediated phase II …
  1057. Cardiac Aging–Benefits of Exercise, Nrf2 Activation and Antioxidant Signaling
  1058. Activation of the Nrf2 signaling pathway and neuroprotection of nigral dopaminergic neurons by a novel synthetic compound KMS99220
  1059. … induces Sertoli cell apoptosis in mice via ROS/JNK-dependent activation of the mitochondrial pathway and inhibition of Nrf2-mediated antioxidant response
  1060. Forsythiaside A exhibits anti-inflammatory effects in LPS-stimulated BV2 microglia cells through activation of Nrf2/HO-1 signaling pathway
  1061. Construction of a novel quinoxaline as a new class of Nrf2 activator
  1062. Applying an electrophilicity-based strategy to develop a novel nrf2 activator inspired from dietary [6]-shogaol
  1063. Activation of Nrf2 attenuates pulmonary vascular remodeling via inhibiting endothelial-to-mesenchymal transition: an insight from a plant polyphenol
  1064. Characterization of the potent, selective Nrf2 activator, 3-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2h-chromen-2-one, in cellular and in vivo models of pulmonary …
  1065. Ferulic acid (FA) abrogates γ-radiation induced oxidative stress and DNA damage by up-regulating nuclear translocation of Nrf2 and activation of NHEJ pathway
  1066. Chicoric acid prevents methotrexate-induced kidney injury by suppressing NF-κB/NLRP3 inflammasome activation and up-regulating Nrf2/ARE/HO-1 signaling
  1067. Colon-Targeted delivery facilitates the therapeutic switching of sofalcone, a gastroprotective agent, to an anticolitic drug via Nrf2 activation
  1068. 5-(3, 4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1, 2, 4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute …
  1069. Therapeutic potential of Salviae miltiorrhizae Radix et Rhizoma against human diseases based on activation of Nrf2-mediated antioxidant defense system …
  1070. Synthesis, evaluation, and metabolism of novel [6]-shogaol derivatives as potent Nrf2 activators
  1071. Reduced Nrf2 activation in PI3K phosphorylation‐impaired vitiliginous keratinocytes increases susceptibility to ROS‐generating chemical‐induced apoptosis
  1072. Ethanol Extract of Centipeda minima Exerts Antioxidant and Neuroprotective Effects via Activation of the Nrf2 Signaling Pathway
  1073. Activation of the Nrf2/ARE signaling pathway by probucol contributes to inhibiting inflammation and neuronal apoptosis after spinal cord injury
  1074. Rapamycin protects against paraquat-induced pulmonary fibrosis: activation of Nrf2 signaling pathway
  1075. Activation of Nrf2 by sulforaphane inhibits high glucose-induced progression of pancreatic cancer via AMPK dependent signaling
  1076. Pterostilbene decreases cardiac oxidative stress and inflammation via activation of AMPK/Nrf2/HO-1 pathway in fructose-fed diabetic rats
  1077. Andrographolide protects chondrocytes from oxidative stress injury by activation of the Keap1–Nrf2–Are signaling pathway
  1078. Calycosin suppresses expression of pro-inflammatory cytokines via the activation of p62/Nrf2-linked heme oxygenase 1 in rheumatoid arthritis synovial fibroblasts
  1079. Anti-inflammatory activity of myricetin from Diospyros lotus through suppression of NF-κB and STAT1 activation and Nrf2-mediated HO-1 induction in …
  1080. Magnesium lithospermate B protects the endothelium from inflammation-induced dysfunction through activation of Nrf2 pathway
  1081. Protective effect of phloroglucinol on oxidative stress-induced DNA damage and apoptosis through activation of the Nrf2/HO-1 signaling pathway in HaCaT human …
  1082. Aurothioglucose does not improve alveolarization or elicit sustained Nrf2 activation in C57BL/6 models of bronchopulmonary dysplasia
  1083. Xueshuantong Injection (Lyophilized) Attenuates Cerebral Ischemia/Reperfusion Injury by the Activation of Nrf2–VEGF Pathway
  1084. Resveratrol represses estrogen-induced mammary carcinogenesis through NRF2-UGT1A8-estrogen metabolic axis activation
  1085. 3H-1, 2-dithiole-3-thione protects retinal pigment epithelium cells against Ultra-violet radiation via activation of Akt-mTORC1-dependent Nrf2-HO-1 signaling
  1086. Activation of Nrf2 reduces UVA-mediated MMP-1 upregulation via MAPK/AP-1 signaling cascades: the photoprotective effects of sulforaphane and hispidulin
  1087. … alterations in a mouse cardiac model of Friedreich ataxia: an impaired Nrf2 response mediated via upregulation of Keap1 and activation of the Gsk3β axis
  1088. Nrf2 pathway activation upon rotenone treatment in human iPSC-derived neural stem cells undergoing differentiation towards neurons and astrocytes
  1089. Activation of Keap1-Nrf2 signaling by 4-octyl itaconate protects human umbilical vein endothelial cells from high glucose
  1090. Protective effects of fucoxanthin against alcoholic liver injury by activation of Nrf2-mediated antioxidant defense and inhibition of TLR4-mediated inflammation
  1091. Activation of Nrf2 attenuates delayed gastric emptying in obesity induced diabetic (T2DM) female mice
  1092. Nrf2 downregulates zymosan-induced neutrophil activation and modulates migration
  1093. Hepatocyte-protective effect of nectandrin B, a nutmeg lignan, against oxidative stress: Role of Nrf2 activation through ERK phosphorylation and AMPK-dependent …
  1094. N-acetylcysteine alleviates fluoride-induced testicular apoptosis by modulating IRE1α/JNK signaling and nuclear Nrf2 activation
  1095. Activation of Nrf2 signaling by salvianolic acid C attenuates NF‑κB mediated inflammatory response both in vivo and in vitro
  1096. Propofol induces proliferation partially via downregulation of p53 protein and promotes migration via activation of the Nrf2 pathway in human breast cancer …
  1097. Ethanol extract of Ganoderma lucidum augments cellular anti-oxidant defense through activation of Nrf2/HO-1
  1098. Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated …
  1099. Hyperoside attenuates dextran sulfate sodium-induced colitis in mice possibly via activation of the Nrf2 signalling pathway
  1100. Protective effect of Nrf2–ARE activator isolated from green perilla leaves on dopaminergic neuronal loss in a Parkinson’s disease model
  1101. Amelioration of oxidative stress in Caco-2 cells treated with pro-inflammatory proteins by chlorogenic acid isomers via activation of the Nrf2–Keap1–ARE-signaling …
  1102. Dexmedetomidine alleviates hepatic injury via the inhibition of oxidative stress and activation of the Nrf2/HO-1 signaling pathway
  1103. … alleviates lipopolysaccharide and D-galactosamine-induced acute liver injury by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation
  1104. Renal toxicity through AhR, PXR, and Nrf2 signaling pathway activation of ochratoxin A-induced oxidative stress in kidney cells
  1105. Triptolide attenuates myocardial ischemia/reperfusion injuries in rats by inducing the activation of Nrf2/HO-1 defense pathway
  1106. Hyperoside alleviated N-acetyl-para-amino-phenol-induced acute hepatic injury via Nrf2 activation
  1107. Activation of Nrf2/HO-1 signal with Myricetin for attenuating ECM degradation in human chondrocytes and ameliorating the murine osteoarthritis
  1108. Quercetin and its metabolites protect hepatocytes against ethanol-induced oxidative stress by activation of Nrf2 and AP-1
  1109. Salvianolic acid A protects against oxidative stress and apoptosis induced by intestinal ischemia-reperfusion injury through activation of Nrf2/HO-1 pathways
  1110. Ulinastatin protects against CVB3-induced acute viral myocarditis through Nrf2 activation
  1111. Organic dust, causing both oxidative stress and Nrf2 activation, is phagocytized by bronchial epithelial cells
  1112. Epigallocatechin-3-gallate enhances radiation sensitivity in colorectal cancer cells through Nrf2 activation and autophagy
  1113. … effects of esculetin against oxidative stress are associated with the upregulation of Nrf2-mediated NQO1 expression via the activation of the ERK pathway
  1114. Ginsenoside Rg1 protects cardiomyocytes against hypoxia/reoxygenation injury via activation of Nrf2/HO-1 signaling and inhibition of JNK
  1115. Orientin-mediated Nrf2/HO-1 signal alleviates H2O2-induced oxidative damage via induction of JNK and PI3K/AKT activation
  1116. The protective role of vitamin D3 in a murine model of asthma via the suppression of TGF-β/Smad signaling and activation of the Nrf2/HO-1 pathway
  1117. Concomitant Nrf2-and ATF4-activation by carnosic acid cooperatively induces expression of cytoprotective genes
  1118. Possible activation of NRF2 by Vitamin E/Curcumin against altered thyroid hormone induced oxidative stress via NFĸB/AKT/mTOR/KEAP1 signalling in rat …
  1119. Investigation of Nrf2, AhR and ATF4 activation in toxicogenomic databases
  1120. Activation of Nrf2 signaling as a common treatment of neurodegenerative diseases
  1121. Anthocyanin delphinidin prevents neoplastic transformation of mouse skin JB6 P+ cells: epigenetic re-activation of Nrf2-ARE pathway
  1122. Recurrent loss of NFE2L2 exon 2 is a mechanism for Nrf2 pathway activation in human cancers
  1123. α-Lipoic acid prevents against cisplatin cytotoxicity via activation of the NRF2/HO-1 antioxidant pathway
  1124. Activation of Nrf2 by phloretin attenuates palmitic acid-induced endothelial cell oxidative stress via AMPK-dependent signaling
  1125. Activation of p62-keap1-Nrf2 antioxidant pathway in the early stage of acetaminophen-induced acute liver injury in mice
  1126. Sulforaphane protects granulosa cells against oxidative stress via activation of NRF2-ARE pathway
  1127. Cryptotanshinone from the Salvia miltiorrhiza Bunge Attenuates Ethanol-Induced Liver Injury by Activation of AMPK/SIRT1 and Nrf2 Signaling Pathways
  1128. … action of N-acetyl serotonin in oxidative stress-induced apoptosis through the activation of both TrkB/CREB/BDNF pathway and Akt/Nrf2/Antioxidant enzyme in …
  1129. Activation of Akt and JNK/Nrf2/NQO1 pathway contributes to the protective effect of coptisine against AAPH-induced oxidative stress
  1130. Irisin pretreatment ameliorates intestinal ischemia/reperfusion injury in mice through activation of the Nrf2 pathway
  1131. Notoginsenoside R1 ameliorates diabetic encephalopathy by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation
  1132. Aspirin induces Nrf2‐mediated transcriptional activation of haem oxygenase‐1 in protection of human melanocytes from H2O2‐induced oxidative stress
  1133. Asbestos induces oxidative stress and activation of Nrf2 signaling in murine macrophages: chemopreventive role of the synthetic lignan secoisolariciresinol …
  1134. Noncanonical SQSTM1/p62-Nrf2 pathway activation mediates proteasome inhibitor resistance in multiple myeloma cells via redox, metabolic and …
  1135. JWA antagonizes paraquat-induced neurotoxicity via activation of Nrf2
  1136. Hydrogen-rich water intake accelerates oral palatal wound healing via activation of the Nrf2/antioxidant defense pathways in a rat model
  1137. Lycium barbarum polysaccharide protects HSF cells against ultraviolet-induced damage through the activation of Nrf2
  1138. Sulforaphane prevents methylmercury-induced oxidative damage and excitotoxicity through activation of the Nrf2-ARE pathway
  1139. Propolis reversed cigarette smoke-induced emphysema through macrophage alternative activation independent of Nrf2
  1140. Mulberry crude extracts induce Nrf2 activation and expression of detoxifying enzymes in rat liver: Implication for its protection against NP-induced toxic effects
  1141. … rhamnosus GG and its supernatant against myocardial dysfunction in obese mice exposed to intermittent hypoxia is associated with the activation of Nrf2 …
  1142. Hesperidin attenuates learning and memory deficits in APP/PS1 mice through activation of Akt/Nrf2 signaling and inhibition of RAGE/NF-κB signaling
  1143. NRF2 regulates endothelial glycolysis and proliferation with miR-93 and mediates the effects of oxidized phospholipids on endothelial activation
  1144. Protective effect of hyperoside on cardiac ischemia reperfusion injury through inhibition of ER stress and activation of Nrf2 signaling
  1145. Mechanism of rapid nuclear factor-E2-related factor 2 (Nrf2) activation via membrane-associated estrogen receptors: roles of NADPH oxidase 1, neutral …
  1146. FGF19 protects hepatocellular carcinoma cells against endoplasmic reticulum stress via activation of FGFR4–GSK3β–Nrf2 signaling
  1147. Grape peel extract and resveratrol inhibit wrinkle formation in mice model through activation of Nrf2/HO‐1 signaling pathway
  1148. Activation of the Nrf2/HO-1 signaling pathway contributes to the protective effects of baicalein against oxidative stress-induced DNA damage and apoptosis in …
  1149. Activation of Nrf2-mediated anti-oxidant genes by antrodin C prevents hyperglycemia-induced senescence and apoptosis in human endothelial cells
  1150. MicroRNA-27b inhibition promotes Nrf2/ARE pathway activation and alleviates intracerebral hemorrhage-induced brain injury
  1151. Alpha lipoic acid exerts antioxidant effect via Nrf2/HO-1 pathway activation and suppresses hepatic stellate cells activation induced by methotrexate in rats
  1152. Oncogenic activation of Nrf2, though as a master antioxidant transcription factor, liberated by specific knockout of the full-length Nrf1α that acts as a dominant tumor …
  1153. Activation of autophagic flux and the Nrf2/ARE signaling pathway by hydrogen sulfide protects against acrylonitrile-induced neurotoxicity in primary rat astrocytes
  1154. Activation of Nrf2/HO-1 pathway by glycogen synthase kinase-3β inhibition attenuates renal ischemia/reperfusion injury in diabetic rats
  1155. Minocycline attenuates sevoflurane-induced cell injury via activation of Nrf2
  1156. Antioxidants cinnamaldehyde and Galactomyces fermentation filtrate downregulate senescence marker CDKN2A/p16INK4A via NRF2 activation in keratinocytes
  1157. Activation of Nrf2 signaling by Icariin protects against 6‐OHDA‐induced neurotoxicity
  1158. Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies
  1159. The bright side of plasmonic gold nanoparticles; activation of Nrf2, the cellular protective pathway
  1160. Activation of Nrf2 contributes to the protective effect of Exendin-4 against angiotensin II-induced vascular smooth muscle cell senescence
  1161. Dehydroepiandrosterone alleviates oxidative stress and apoptosis in iron-induced epilepsy via activation of Nrf2/ARE signal pathway
  1162. Soybean-derived phytoalexins improve cognitive function through activation of Nrf2/HO-1 signaling pathway
  1163. Mechanisms of NRF2 activation to mediate fetal hemoglobin induction and protection against oxidative stress in sickle cell disease
  1164. Isoliquiritigenin protects against triptolide-induced hepatotoxicity in mice through Nrf2 activation
  1165. Aucubin, a natural iridoid glucoside, attenuates oxidative stress-induced testis injury by inhibiting JNK and CHOP activation via Nrf2 up-regulation
  1166. Lycopene inhibits NF-κB activation and adhesion molecule expression through Nrf2-mediated heme oxygenase-1 in endothelial cells
  1167. Nrf2 activation inhibits effects of thrombin in human amnion cells and thrombin-induced preterm birth in mice
  1168. Melatonin protects against arsenic trioxide-induced liver injury by the upregulation of Nrf2 expression through the activation of PI3K/AKT pathway
  1169. … efficacy and the upregulation of Nrf2-mediated HO-1 expression by (+)-lariciresinol, a lignan isolated from Rubia philippinensis, through the activation of p38
  1170. Artemether Activation of AMPK/GSK3β(ser9)/Nrf2 Signaling Confers Neuroprotection towards β-Amyloid-Induced Neurotoxicity in 3xTg Alzheimer’s Mouse …
  1171. Novel protective mechanism of reducing renal cell damage in diabetes: activation AMPK by AICAR increased NRF2/OGG1 proteins and reduced oxidative DNA …
  1172. Novel diterpenoid-type activators of the Keap1/Nrf2/ARE signaling pathway and their regulation of redox homeostasis
  1173. Autophagy involved in the activation of the Nrf2-antioxidant system in testes of heat-exposed mice
  1174. Activation of anti-oxidant of curcumin pyrazole derivatives through preservation of mitochondria function and Nrf2 signaling pathway
  1175. Protective effects of curcumin against mercury-induced hepatic injuries in rats, involvement of oxidative stress antagonism, and Nrf2-ARE pathway activation
  1176. … M is an anti-aging reagent that eliminates hyperglycemia-accelerated premature senescence in dermal fibroblasts by direct activation of Nrf2 and SIRT-1
  1177. Isovitexin alleviates liver injury induced by lipopolysaccharide/d-galactosamine by activating Nrf2 and inhibiting NF-κB activation
  1178. Naringenin Ameliorates Behavioral Dysfunction and Neurological Deficits in a d-Galactose-Induced Aging Mouse Model Through Activation of PI3K/Akt/Nrf2 Pathway
  1179. Transcriptional activation of follistatin by Nrf2 protects pulmonary epithelial cells against silica nanoparticle-induced oxidative stress
  1180. Neferine prevents autophagy induced by hypoxia through activation of Akt/mTOR pathway and Nrf2 in muscle cells
  1181. Anti-neuroinflammatory Activity of Elephantopus scaber L. via Activation of Nrf2/HO-1 Signaling and Inhibition of p38 MAPK Pathway in LPS-Induced …
  1182. … A4 restores oxidative stress-induced vascular endothelial cell injury and thrombosis-related factor expression by its receptor-mediated activation of Nrf2-HO-1 axis
  1183. Synthesis of new ferulic/lipoic/comenic acid-melatonin hybrids as antioxidants and Nrf2 activators via Ugi reaction
  1184. Inhibiting adhesion events by Panax notoginseng saponins and Ginsenoside Rb1 protecting arteries via activation of Nrf2 and suppression of p38–VCAM-1 signal …
  1185. The association between oxidative stress alleviation via sulforaphane-induced Nrf2-HO-1/NQO-1 signaling pathway activation and chronic renal allograft …
  1186. Neglected role of hydrogen sulfide in sulfur mustard poisoning: Keap1 S-sulfhydration and subsequent Nrf2 pathway activation
  1187. Piceatannol protects against cisplatin nephrotoxicity via activation of Nrf2/HO-1 pathway and hindering NF-κB inflammatory cascade
  1188. Berberine protects immortalized line of human melanocytes from H2O2-induced oxidative stress via activation of Nrf2 and Mitf signaling pathway
  1189. Sageretia thea Inhibits Inflammation through Suppression of NF-B and MAPK and Activation of Nrf2/HO-1 Signaling Pathways in RAW264.7 Cells
  1190. Inhibition of autophagy reverses alcohol-induced hepatic stellate cells activation through activation of Nrf2-Keap1-ARE signaling pathway
  1191. Anti-inflammatory effect of erinacine C on NO production through down-regulation of NF-κB and activation of Nrf2-mediated HO-1 in BV2 microglial cells treated with …
  1192. … action of tea polyphenols on oxidative stress-induced apoptosis through the activation of the TrkB/CREB/BDNF pathway and Keap1/Nrf2 signaling pathway in SH …
  1193. Fumaric acid esters promote neuronal survival upon ischemic stress through activation of the Nrf2 but not HIF-1 signaling pathway
  1194. Co–Cr dental alloys induces cytotoxicity and inflammatory responses via activation of Nrf2/antioxidant signaling pathways in human gingival fibroblasts and …
  1195. Eriodictyol attenuates arsenic trioxide-induced liver injury by activation of Nrf2
  1196. L-carnitine regulated Nrf2/Keap1 activation in vitro and in vivo and protected oxidized fish oil-induced inflammation response by inhibiting the NF-κB signaling …
  1197. Celastrol attenuates angiotensin II mediated human umbilical vein endothelial cells damage through activation of Nrf2/ERK1/2/Nox2 signal pathway
  1198. Asiatic acid ameliorates doxorubicin-induced cardiac and hepato-renal toxicities with Nrf2 transcriptional factor activation in rats
  1199. Diallyl trisulfide suppresses tumor growth through the attenuation of Nrf2/Akt and activation of p38/JNK and potentiates cisplatin efficacy in gastric cancer …
  1200. Salidroside protects against bleomycin-induced pulmonary fibrosis: activation of Nrf2-antioxidant signaling, and inhibition of NF-κB and TGF-β1/Smad-2/-3 pathways
  1201. Preconditioning by low dose LPS prevents subsequent LPS-induced severe liver injury via Nrf2 activation in mice
  1202. Activation of Nrf2 by MIND4-17 protects osteoblasts from hydrogen peroxide-induced oxidative stress
  1203. Aspirin suppresses neuronal apoptosis, reduces tissue inflammation, and restrains astrocyte activation by activating the Nrf2/HO-1 signaling pathway
  1204. Activation of Nrf2 and hypoxic adaptive response contribute to neuroprotection elicited by phenylhydroxamic acid selective HDAC6 inhibitors
  1205. Polydatin protects against acute myocardial infarction-induced cardiac damage by activation of Nrf2/HO-1 signaling
  1206. Antiviral effect of 7-(4-benzimidazole-butoxy)-coumarin on rhabdoviral clearance via Nrf2 activation regulated by PKCα/β phosphorylation
  1207. Dietary oleuropein and its new acyl-derivate attenuate murine lupus nephritis through HO-1/Nrf2 activation and suppressing JAK/STAT, NF-κB, MAPK and NLRP3 …
  1208. Helenalin from Centipeda minima ameliorates acute hepatic injury by protecting mitochondria function, activating Nrf2 pathway and inhibiting NF-κB activation
  1209. Sodium valproate prevents radiation-induced injury in hippocampal neurons via activation of the Nrf2/HO-1 pathway
  1210. Activation of the Nrf2 signaling pathway involving KLF9 plays a critical role in allicin resisting against arsenic trioxide-induced hepatotoxicity in rats
  1211. … of Nrf2-mediated heme oxygenase-1 expression in anti-inflammatory action of chitosan oligosaccharides through MAPK activation in murine macrophages
  1212. Anthraquinone and naphthopyrone glycosides from Cassia obtusifolia seeds mediate hepatoprotection via Nrf2-mediated HO-1 activation and MAPK modulation
  1213. Nrf2 activation ameliorates cytotoxic effects of arsenic trioxide in acute promyelocytic leukemia cells through increased glutathione levels and arsenic efflux from cells
  1214. Benznidazole, the trypanocidal drug used for Chagas disease, induces hepatic NRF2 activation and attenuates the inflammatory response in a murine model of sepsis
  1215. Andrographolide protects PC12 cells against β-amyloid-induced autophagy-associated cell death through activation of the Nrf2-mediated p62 signaling pathway
  1216. Andrographolide Activates Keap1/Nrf2/ARE/HO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by Aβ42 through Nrf2-Related Inflammatory …
  1217. Retracted: Activation of the Nrf2‐ARE Signaling Pathway Prevents Hyperphosphatemia‐Induced Vascular Calcification by Inducing Autophagy in Renal Vascular …
  1218. Proanthocyanidins antagonize arsenic-induced oxidative damage and promote arsenic methylation through activation of the Nrf2 signaling pathway
  1219. Ameliorating mitochondrial dysfunction restores carbon ion-induced cognitive deficits via co-activation of NRF2 and PINK1 signaling pathway
  1220. Xiaochaihutang inhibits the activation of hepatic stellate cell line T6 through the Nrf2 pathway
  1221. Activation of Nrf2/Keap1 pathway by oral Dimethylfumarate administration alleviates oxidative stress and age-associated infertility might be delayed in the …
  1222. Effects of 3‐Bromo‐4, 5‐dihydroisoxazole Derivatives on Nrf2 Activation and Heme Oxygenase‐1 Expression
  1223. 20C, a bibenzyl compound isolated from Gastrodia elata, protects PC12 cells against rotenone-induced apoptosis via activation of the Nrf2/ARE/HO-1 …
  1224. Two sesquiterpene aminoquinones protect against oxidative injury in HaCaT keratinocytes via activation of AMPKα/ERK-Nrf2/ARE/HO-1 signaling
  1225. Forsythiaside A protects against focal cerebral ischemic injury by mediating the activation of the Nrf2 and endoplasmic reticulum stress pathways
  1226. Taurine protects mouse spermatocytes from ionizing radiation-induced damage through activation of Nrf2/HO-1 signaling
  1227. … protective effect of the total flavonoids of Abelmoschus esculentus L. flowers on transient cerebral ischemia-reperfusion injury is due to activation of the Nrf2 …
  1228. Pterostilbene protects against uraemia serum-induced endothelial cell damage via activation of Keap1/Nrf2/HO-1 signaling
  1229. Spica prunellae and its marker compound rosmarinic acid induced the expression of efflux transporters through activation of Nrf2-mediated signaling pathway in …
  1230. Chrysin attenuates carrageenan-induced pleurisy and lung injury via activation of SIRT1/NRF2 pathway in rats
  1231. … -induced cardiotoxicity and genotoxicity by an indole-based natural compound 3, 3′-diindolylmethane (DIM) through activation of Nrf2/ARE signaling pathways and …
  1232. Lycopene ameliorates atrazine-induced oxidative damage in adrenal cortex of male rats by activation of the Nrf2/HO-1 pathway
  1233. Targeting crosstalk between Nuclear factor (erythroid-derived 2)-like 2 and Nuclear factor kappa beta pathway by Nrf2 activator dimethyl fumarate in epileptogenesis
  1234. A novel GSK-3β inhibitor YQ138 prevents neuronal injury induced by glutamate and brain ischemia through activation of the Nrf2 signaling pathway
  1235. The antidepressant-like effect of guanosine is dependent on GSK-3β inhibition and activation of MAPK/ERK and Nrf2/heme oxygenase-1 signaling pathways
  1236. Activation of the Nrf2-ARE pathway ameliorates hyperglycemia-mediated mitochondrial dysfunction in podocytes partly through Sirt1
  1237. Kinsenoside ameliorates intervertebral disc degeneration through the activation of AKT-ERK1/2-Nrf2 signaling pathway
  1238. Tryptanthrin suppresses the activation of the LPS-treated BV2 microglial cell line via Nrf2/HO-1 antioxidant signaling
  1239. TGF-β and Hypoxia/Reoxygenation Promote Radioresistance of A549 Lung Cancer Cells through Activation of Nrf2 and EGFR
  1240. Boric acid activation of eIF2α and Nrf2 is PERK dependent: a mechanism that explains how boron prevents DNA damage and enhances antioxidant status
  1241. Drug screens of NGLY1 deficiency in worm and fly models reveal catecholamine, NRF2 and anti-inflammatory-pathway activation as potential clinical approaches
  1242. Kiwi fruit (Actinidia deliciosa) ameliorates gentamicin-induced nephrotoxicity in albino mice via the activation of Nrf2 and the inhibition of NF-κB (Kiwi & gentamicin …
  1243. Activation of Nrf2/ARE signaling pathway attenuates lanthanum chloride induced injuries in primary rat astrocytes
  1244. Simultaneous activation of Nrf2 and elevation of dietary and endogenous antioxidant chemicals for cancer prevention in humans
  1245. … regulation of innate immune cytokine production through pharmacological activation of Nuclear Factor-Erythroid-2-Related Factor 2 (NRF2) in burn patient …
  1246. 4-Hydroperoxy-2-decenoic acid ethyl ester protects against 6-hydroxydopamine-induced cell death via activation of Nrf2-ARE and eIF2α-ATF4 pathways
  1247. Equol attenuates atherosclerosis in apolipoprotein E-deficient mice by inhibiting endoplasmic reticulum stress via activation of Nrf2 in endothelial cells
  1248. L-ascorbic acid and α-tocopherol attenuate arsenic trioxide-induced toxicity in H9c2 cardiomyocytes by the activation of Nrf2 and Bcl2 transcription factors
  1249. Activation of the Nrf2-ARE signal pathway after blast induced traumatic brain injury in mice
  1250. … cytoprotective effects against oxidative stress in C2C12 myoblasts via the upregulation of Nrf2-dependent HO-1 expression and the activation of the ERK …
  1251. TTB Protects Astrocytes Against Oxygen-Glucose Deprivation/Reoxygenation-Induced Injury via Activation of Nrf2/HO-1 Signaling Pathway
  1252. Dynorphin activation of kappa opioid receptor protects against epilepsy and seizure-induced brain injury via PI3K/Akt/Nrf2/HO-1 pathway
  1253. Pomegranate (Punica granatum L.) wine polyphenols affect Nrf2 activation and antioxidant enzyme expression in human neuroblastoma cells (SH-SY5Y)
  1254. Activation of anti-oxidant Nrf2 signaling by substituted trans stilbenes
  1255. Ultraviolet B irradiation induced Nrf2 degradation occurs via activation of TRPV1 channels in human dermal fibroblasts
  1256. DADLE improves hepatic ischemia/reperfusion injury in mice via activation of the Nrf2/HO‑1 pathway
  1257. … roots inhibit the production of pro-inflammatory mediators through the inhibition of NF-κB and MAPK signaling, and activation of ROS/Nrf2/HO-1 signaling in …
  1258. Soluble P-selectin promotes retinal ganglion cell survival through activation of Nrf2 signaling after ischemia injury
  1259. Z-Guggulsterone attenuates glucocorticoid-induced osteoporosis through activation of Nrf2/HO-1 signaling
  1260. Low-dose dose–response for in vitro Nrf2-ARE activation in human HepG2 cells
  1261. Inhibition of JNK and activation of the AMPK-Nrf2 axis by corosolic acid suppress osteolysis and oxidative stress
  1262. Lipoicmethylenedioxyphenol reduces experimental atherosclerosis through activation of Nrf2 signaling
  1263. TCF7L1 indicates prognosis and promotes proliferation through activation of Keap1/NRF2 in gastric cancer
  1264. Sigma-1 receptor activation ameliorates LPS-induced NO production and ROS formation through the Nrf2/HO-1 signaling pathway in cultured astrocytes
  1265. 5‐Aminolevulinic acid exerts renoprotective effect via Nrf2 activation in murine rhabdomyolysis‐induced acute kidney injury
  1266. Selenium supplementation of lung epithelial cells enhances nuclear factor E2-related factor 2 (Nrf2) activation following thioredoxin reductase inhibition
  1267. Nuclear trapping of inactive FOXO1 by the Nrf2 activator diethyl maleate
  1268. Pharmacogenomics of chemically distinct classes of Keap1-Nrf2 activators identify common and unique gene, protein, and pathway responses in vivo
  1269. Remote limb ischaemic postconditioning protects against myocardial ischaemia/reperfusion injury in mice: activation of JAK/STAT3-mediated Nrf2-antioxidant …
  1270. Promising therapeutic effect of thapsigargin nanoparticles on chronic kidney disease through the activation of Nrf2 and FoxO1
  1271. A new BEACON of hope for the treatment of inflammation? The endogenous metabolite itaconate as an alternative activator of the KEAP1-Nrf2 system
  1272. Obeticholic acid protects against diabetic cardiomyopathy by activation of FXR/Nrf2 signaling in db/db mice
  1273. Cytoprotective effects of diosmetin against hydrogen peroxide-induced L02 cell oxidative damage via activation of the Nrf2-ARE signaling pathway
  1274. Proteomics analysis of dendritic cell activation by contact allergens reveals possible biomarkers regulated by Nrf2
  1275. The protective role of tanshinone IIA in silicosis rat model via TGF-β1/Smad signaling suppression, NOX4 inhibition and Nrf2/ARE signaling activation
  1276. Activation of the Nrf2/HO-1 signaling pathway contributes to the protective effects of coptisine against oxidative stress-induced DNA damage and apoptosis in HaCaT …
  1277. Isobavachalcone attenuates Sephadex-induced lung injury via activation of A20 and NRF2/HO-1 in rats
  1278. Ciliary neurotrophic factor (CNTF) protects myocardial cells from oxygen glucose deprivation (OGD)/re-oxygenation via activation of Akt-Nrf2 signaling
  1279. The Bcl‐2 inhibitor venetoclax inhibits Nrf2 antioxidant pathway activation induced by hypomethylating agents in AML
  1280. … tiliroside derivative, 3-O-[(E)-(2-oxo-4-(p-tolyl) but–3–en–1–yl] kaempferol produced inhibition of neuroinflammation and activation of AMPK and Nrf2/HO-1 pathways …
  1281. Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling
  1282. RETRACTED ARTICLE: Activation of PERK-Nrf2 oncogenic signaling promotes Mdm2-mediated Rb degradation in persistently infected HCV culture
  1283. … fields reduces neuroinflammation and ameliorates scopolamine-induced amnesia in mouse brain through its antioxidant ability via Nrf2-HO-1 activation
  1284. Protective properties of Huperzine A through activation Nrf2/ARE‐mediated transcriptional response in X‐rays radiation‐induced NIH3T3 cells
  1285. … stem cells combined with plumbagin alleviates spinal cord injury by affecting oxidative stress, inflammation, apoptotis and the activation of the Nrf2 pathway
  1286. Aldehyde dehydrogenase 2 activation ameliorates CCl4‐induced chronic liver fibrosis in mice by up‐regulating Nrf2/HO‐1 antioxidant pathway
  1287. Activation of the Nrf2/HO-1 Signaling Pathway Contributes to the Protective Effects of Sargassum serratifolium Extract against Oxidative Stress-Induced DNA …
  1288. Procyanidin B2 ameliorates carrageenan-induced chronic nonbacterial prostatitis in rats via anti-inflammatory and activation of the Nrf2 pathway
  1289. Spleen tyrosine kinase-dependent Nrf2 activation regulates oxidative stress-induced cell death in WiL2-NS human B lymphoblasts
  1290. Punicalagin protects H9c2 cardiomyocytes from doxorubicin-induced toxicity through activation of Nrf2/HO-1 signaling
  1291. The angiotensin‐(1‐7)/Mas receptor axis protects from endothelial cell senescence via klotho and Nrf2 activation
  1292. Carnosic acid protects mitochondria of human neuroblastoma SH-SY5Y cells exposed to paraquat through activation of the Nrf2/HO-1Axis
  1293. l-carnitine protects human hepatocytes from oxidative stress-induced toxicity through Akt-mediated activation of Nrf2 signaling pathway
  1294. Circadian control of p75 neurotrophin receptor leads to alternate activation of Nrf2 and c-Rel to reset energy metabolism in astrocytes via brain-derived neurotrophic …
  1295. Anti-inflammatory effect of sulforaphane on LPS-activated microglia potentially through JNK/AP-1/NF-κB inhibition and Nrf2/HO-1 activation
  1296. HX‐1171, a Novel Nrf2 Activator, Induces NQO1 and HMOX1 Expression
  1297. Repetitive exposure to low-dose X-irradiation attenuates testicular apoptosis in type 2 diabetic rats, likely via Akt-mediated Nrf2 activation
  1298. Nrf2-Keap1 activation, a promising strategy in the prevention of cancer
  1299. … TXNIP mediated NLRP3 inflammasome activation in MSU crystal stimulated RAW 264.7 macrophages through the upregulation of Nrf2 transcription factor and …
  1300. Up-regulation of HO-1 by Nrf2 activation protects against palmitic acid-induced ROS increase in human neuroblastoma BE (2)-M17 cells
  1301. Downregulation of Bach1 protects osteoblasts against hydrogen peroxide-induced oxidative damage in vitro by enhancing the activation of Nrf2/ARE signaling
  1302. The novel triterpenoid RTA 408 protects human retinal pigment epithelial cells against H2O2-induced cell injury via NF-E2-related factor 2 (Nrf2) activation
  1303. Activation of Nrf2-ARE signaling mitigates cyclophosphamide-induced myelosuppression
  1304. Neuroprotective effect of fermented papaya preparation by activation of Nrf2 pathway in astrocytes
  1305. Glycyrrhizin protects against sodium iodate‐induced RPE and retinal injury though activation of AKT and Nrf2/HO‐1 pathway
  1306. Association of Neuroprotective Effect of Di-O-Demethylcurcumin on Aβ25–35-Induced Neurotoxicity with Suppression of NF-κB and Activation of Nrf2
  1307. Vanadium(III)-L-cysteine protects cisplatin-induced nephropathy through activation of Nrf2/HO-1 pathway
  1308. Nitro-oleic acid ameliorates oxygen and glucose deprivation/re-oxygenation triggered oxidative stress in renal tubular cells via activation of Nrf2 and suppression of …
  1309. 3-NP-induced Huntington’s-like disease impairs Nrf2 activation without loss of cardiac function in aged rats
  1310. Curcumin prevents high glucose damage in retinal pigment epithelial cells through ERK1/2‐mediated activation of the Nrf2/HO‐1 pathway
  1311. Recuperating lung decoction attenuates inflammation and oxidation in cigarette smoke‐induced COPD in rats via activation of ERK and Nrf2 pathways
  1312. Aloin reduces HMGB1-mediated septic responses and improves survival in septic mice by activation of the SIRT1 and PI3K/Nrf2/HO-1 signaling axis
  1313. Activation of the Nrf2-Keap 1 pathway in short-term iodide excess in thyroid in rats
  1314. … injury in patients with rheumatic valvular heart disease undergoing CPB surgery are associated with the suppression of NF‐κB pathway and the activation of Nrf2 …
  1315. Lansoprazole halts contrast induced nephropathy through activation of Nrf2 pathway in rats
  1316. Activation of autophagy and Nrf2 signaling in human breast adenocarcinoma MCF-7 cells by novel monophenolic antioxidants
  1317. Melatonin protects H9c2 cells against ischemia/reperfusion‑induced apoptosis and oxidative stress via activation of the Nrf2 signaling pathway
  1318. Prunus Mahaleb Fruit Extract Prevents Chemically Induced Colitis and Enhances Mitochondrial Oxidative Metabolism via the Activation of the Nrf2 Pathway
  1319. Lycopene attenuates AFB 1-induced renal injury with the activation of the Nrf2 antioxidant signaling pathway in mice
  1320. Amelioratory effects of testosterone propionate on age-related renal fibrosis via suppression of TGF-β1/Smad signaling and activation of Nrf2-ARE signaling
  1321. Sulforaphane ameliorates bladder dysfunction through activation of the Nrf2-ARE pathway in a rat model of partial bladder outlet obstruction
  1322. Activation of the MAPK/Akt/Nrf2-Egr1/HO-1-GCLc axis protects MG-63 osteosarcoma cells against 15d-PGJ2-mediated cell death
  1323. Pterisolic Acid B is a Nrf2 Activator by Targeting C171 within Keap1-BTB Domain
  1324. Glucose oxidase facilitates osteogenic differentiation and mineralization of embryonic stem cells through the activation of Nrf2 and ERK signal transduction pathways
  1325. Co-activation of PKC-δ by CRIF1 modulates oxidative stress in bone marrow multipotent mesenchymal stromal cells after irradiation by phosphorylating NRF2 …
  1326. Probucol improves erectile function via Activation of Nrf2 and coordinates the HO-1/DDAH/PPAR-γ/eNOS pathways in streptozotocin-induced diabetic rats
  1327. Protective effects of diallyl sulfide on ovalbumin-induced pulmonary inflammation of allergic asthma mice by microRNA-144,-34a, and-34b/c-modulated Nrf2 activation
  1328. Sodium tanshinone IIA sulfonate suppresses pulmonary fibroblast proliferation and activation induced by silica: role of the Nrf2/Trx pathway
  1329. Gambogic acid induces heme oxygenase-1 through Nrf2 signaling pathway and inhibits NF-κB and MAPK activation to reduce inflammation in LPS-activated …
  1330. Methyleugenol protects against t-BHP-triggered oxidative injury by induction of Nrf2 dependent on AMPK/GSK3β and ERK activation
  1331. Lotus seed skin proanthocyanidin extract exhibits potent antioxidant property via activation of the Nrf2–ARE pathway
  1332. Ziziphus spina-christi Leaf Extract Suppressed Mercury Chloride-Induced Nephrotoxicity via Nrf2-Antioxidant Pathway Activation and Inhibition of …
  1333. Hesperetin suppresses inflammatory responses in lipopolysaccharide-induced RAW 264.7 cells via the inhibition of NF-κB and activation of Nrf2/HO-1 pathways
  1334. Suppression of 6-hydroxydopamine-induced oxidative stress by hyperoside via activation of Nrf2/HO-1 signaling in dopaminergic neurons
  1335. … of periostin prevents high glucose-induced mitochondrial apoptosis in human umbilical vein endothelial cells via activation of Nrf2/HO-1 signaling
  1336. Nrf2 activation ameliorates hepatotoxicity induced by a heme synthesis inhibitor
  1337. … serratifolium attenuates RANKL-induced osteoclast differentiation and oxidative stress through inhibition of NF-κB and activation of the Nrf2/HO-1 signaling pathway
  1338. Structured DAG oil ameliorates renal injury in streptozotocin-induced diabetic rats through inhibition of NF-κB and activation of Nrf2 pathway
  1339. Melittin ameliorates CVB3-induced myocarditis via activation of the HDAC2-mediated GSK-3β/Nrf2/ARE signaling pathway
  1340. Enhancement of dopaminergic activity and region-specific activation of Nrf2-ARE pathway by intranasal supplements of testosterone propionate in aged male rats
  1341. Astragaloside IV and ferulic acid synergistically promote neurite outgrowth through Nrf2 activation
  1342. Lignans from Saururus chinensis exhibit anti-inflammatory activity by influencing the Nrf2/HO-1 activation pathway
  1343. Anticancer activity of Honokiol against lymphoid malignant cells via activation of ROS-JNK and attenuation of Nrf2 and NF-κB
  1344. Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in …
  1345. … human dopamine D5 receptor mutation in mice causes a dilated cardiomyopathy through ROS over-generation by NADPH oxidase activation and Nrf2 …
  1346. Activation of Nrf2/HO-1 pathway protects retinal ganglion cells from a rat chronic ocular hypertension model of glaucoma
  1347. … chinensis total lignans on acute alcoholic-induced liver injury related to inhibiting CYP2E1 activation and activating the Nrf2/ARE signaling pathway
  1348. Umbilical cord MSCs reverse D-galactose-induced hepatic mitochondrial dysfunction via activation of Nrf2/HO-1 pathway
  1349. LL202 ameliorates colitis against oxidative stress of macrophage by activation of the Nrf2/HO‐1 pathway
  1350. … from the edible marine algae Padina tetrastromatica attenuates isoproterenol-induced oxidative damage via activation of PI3K/Akt/Nrf2 signaling pathway-an in vitro …
  1351. Stevia rebaudiana tea prevents experimental cirrhosis via regulation of NF‐κB, Nrf2, transforming growth factor beta, Smad7, and hepatic stellate cell activation
  1352. Keap1 cystenine 151 as a potential target for artemisitene-induced Nrf2 activation
  1353. Activation of cannabinoid type 2 receptor protects skeletal muscle from ischemia-reperfusion injury partly via Nrf2 signaling
  1354. Nrf2 activation via Keap1 deletion or sulforaphane treatment reduces Ova-induced sinonasal inflammation
  1355. Gedunin Inhibits Oligomeric Aβ1–42-Induced Microglia Activation Via Modulation of Nrf2-NF-κB Signaling
  1356. GYY4137 protects against myocardial ischemia/reperfusion injury via activation of the PHLPP-1/Akt/Nrf2 signaling pathway in diabetic mice
  1357. … multi-herbal medicine kyung-ok-ko in an animal model of Parkinson’s disease: inhibition of MAPKs and NF-κB pathways and activation of keap1-Nrf2 …
  1358. Nanoceria restrains PM2. 5-induced metabolic disorder and hypothalamus inflammation by inhibition of astrocytes activation related NF-κB pathway in Nrf2 deficient …
  1359. Saikosaponin a inhibits cigarette smoke-induced oxidant stress and inflammatory responses by activation of Nrf2
  1360. Critical role of p21 on olaquindox-induced mitochondrial apoptosis and S-phase arrest involves activation of PI3K/AKT and inhibition of Nrf2/HO-1pathway
  1361. The Ethanol Extract of Licorice (Glycyrrhiza uralensis) Protects against Triptolide-Induced Oxidative Stress through Activation of Nrf2
  1362. Antidepressant effects of TBE-31 and MCE-1, the novel Nrf2 activators, in an inflammation model of depression
  1363. … Velvet Antler (Cervus elaphus) against Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting MAPK/NF-κB Activation and Inducing AMPK/Nrf2 …
  1364. Cyanidin-3-O-glucoside inhibits NF-kB signalling in intestinal epithelial cells exposed to TNF-α and exerts protective effects via Nrf2 pathway activation
  1365. Dimethyl fumarate accelerates peripheral nerve regeneration via activation of the anti-inflammatory and cytoprotective Nrf2/HO-1 signaling pathway
  1366. Sulforaphane exerts its anti-inflammatory effect against amyloid-β peptide via STAT-1 dephosphorylation and activation of Nrf2/HO-1 cascade in human THP-1 …
  1367. HO‑1 alleviates cholesterol‑induced oxidative stress through activation of Nrf2/ERK and inhibition of PI3K/AKT pathways in endothelial cells
  1368. Homoeriodictyol protects human endothelial cells against oxidative insults through activation of Nrf2 and inhibition of mitochondrial dysfunction
  1369. Ginsenoside re inhibits ROS/ASK-1 dependent mitochondrial apoptosis pathway and activation of Nrf2-antioxidant response in beta-amyloid-challenged SH-SY5Y …
  1370. Hepatocellular iNOS protects liver from NASH through Nrf2-dependent activation of HO-1
  1371. Peanut arachidin-1 enhances Nrf2-mediated protective mechanisms against TNF-α-induced ICAM-1 expression and NF-κB activation in endothelial cells
  1372. Herbal formula SC-E1 suppresses lipopolysaccharide-stimulated inflammatory responses through activation of Nrf2/HO-1 signaling pathway in RAW 264.7 …
  1373. … -methylhonokiol ameliorates type 2 diabetes-induced nephropathy in mice likely by activation of AMPK-mediated fatty acid oxidation and Nrf2-mediated anti-oxidative …
  1374. Diallyl sulfide attenuates transforming growth factor-β-stimulated pulmonary fibrosis through Nrf2 activation in lung MRC-5 fibroblast
  1375. … -gallate ameliorates angiotensin II-induced oxidative stress and apoptosis in human umbilical vein endothelial cells through the activation of Nrf2/caspase-3 signaling
  1376. Early antioxidant responses via the concerted activation of NF-κB and Nrf2 characterize the gamma-radiation-induced adaptive response in quiescent human …
  1377. Hydroxytyrosol butyrate inhibits 6-OHDA-induced apoptosis through activation of the Nrf2/HO-1 axis in SH-SY5Y cells
  1378. Mechanism of Emulsified Isoflurane Postconditioning–Induced Activation of the Nrf2–Antioxidant Response Element Signaling Pathway During Myocardial Ischemia …
  1379. Trans-cinnamic acid attenuates UVA-induced photoaging through inhibition of AP-1 activation and induction of Nrf2-mediated antioxidant genes in human skin …
  1380. Rosmarinic acid counteracts activation of hepatic stellate cells via inhibiting the ROS-dependent MMP-2 activity: Involvement of Nrf2 antioxidant system
  1381. Contrasting effects of a classic Nrf2 activator, tert-butylhydroquinone, on the glutathione-related antioxidant defenses in Pacific oysters, Crassostrea gigas
  1382. CRISPR/Cas9 editing of glia maturation factor regulates mitochondrial dynamics by attenuation of the NRF2/HO-1 dependent ferritin activation in glial cells
  1383. Astragaloside IV attenuates lead acetate-induced inhibition of neurite outgrowth through activation of Akt-dependent Nrf2 pathway in vitro
  1384. Oncogenic mutations in KEAP1 disturbing inhibitory Nrf2‐Keap1 interaction: Activation of antioxidative pathway in papillary thyroid carcinoma
  1385. Sulforaphane prevents angiotensin II-induced testicular cell death via activation of NRF2
  1386. Anti-inflammatory activity of 8-hydroxydaidzein in LPS-stimulated BV2 microglial cells via activation of Nrf2-antioxidant and attenuation of Akt/NF-κB-inflammatory …
  1387. Cyanidin‐3‐glucoside and its phenolic acid metabolites attenuate visible light‐induced retinal degeneration in vivo via activation of Nrf2/HO‐1 pathway and NF‐κB …
  1388. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of LPS-induced inflammation and redox imbalance: Evidence from in …
  1389. Methionine sulfoxide reductase B3 deficiency stimulates heme oxygenase-1 expression via ROS-dependent and Nrf2 activation pathways
  1390. α-Cyperone inhibits LPS-induced inflammation in BV-2 cells through activation of Akt/Nrf2/HO-1 and suppression of the NF-κB pathway
  1391. Interleukin-18 binding protein attenuates lipopolysaccharide-induced acute lung injury in mice via suppression NF-κB and activation Nrf2 pathway
  1392. … effects of oxymatrine against lipopolysaccharide/D‑galactosamine‑induced acute liver failure through oxidative damage, via activation of Nrf2/HO‑1 and …
  1393. Withaferin A induces heme oxygenase (HO-1) expression in endothelial cells via activation of the Keap1/Nrf2 pathway
  1394. Transcriptional regulation of Hb‐α and Hb‐β through nuclear factor E2‐related factor‐2 (Nrf2) activation in human vaginal cells: A novel mechanism of cellular …
  1395. DHA and vitamin e antagonized the Aβ 25–35-mediated neuron oxidative damage through activation of Nrf2 signaling pathways and regulation of CD36, SRB1 and …
  1396. Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling
  1397. … and Mr. Hyde: Oxidizable phenol-generated reactive oxygen species enhance sulforaphane’s antioxidant response element activation, even as they suppress Nrf2 …
  1398. 7-deacetylgedunin suppresses inflammatory responses through activation of Keap1/Nrf2/HO-1 signaling
  1399. Piceatannol protects ARPE-19 cells against vitamin A dimer-mediated photo-oxidative damage through activation of Nrf2/NQO1 signalling
  1400. … extract of Prunus mume fruit attenuates hydrogen peroxide-induced oxidative stress and apoptosis involving Nrf2/HO-1 activation in C2C12 myoblasts
  1401. Apigenin attenuates oxidative injury in ARPE-19 cells thorough activation of Nrf2 pathway
  1402. HX-1171 attenuates pancreatic β-cell apoptosis and hyperglycemia-mediated oxidative stress via Nrf2 activation in streptozotocin-induced diabetic model
  1403. Therapeutic effect of Mahaenggamseok-tang on neutrophilic lung inflammation is associated with NF-κB suppression and Nrf2 activation
  1404. Isoflavone biochanin A, a novel nuclear factor erythroid 2‐related factor 2 (Nrf2)‐antioxidant response element activator, protects against oxidative damage in HepG2 …
  1405. Nardochinoid B inhibited the activation of RAW264. 7 macrophages stimulated by lipopolysaccharide through activating the Nrf2/HO-1 pathway
  1406. Quercetin phospholipid complex significantly protects against oxidative injury in ARPE-19 cells associated with activation of Nrf2 pathway
  1407. Propofol post‐conditioning alleviates hepatic ischaemia reperfusion injury via BRG1‐mediated Nrf2/HO‐1 transcriptional activation in human and mice
  1408. Activation of p38MAPK and NRF2 signaling pathways in the toxicity induced by chlorpyrifos in Drosophila melanogaster: protective effects of Psidium guajava …
  1409. n-3 Polyunsaturated fatty acids induce acute myeloid leukemia cell death associated with mitochondrial glycolytic switch and Nrf2 pathway activation
  1410. … prevents nonalcoholic fatty liver disease (NAFLD) and hyperlipidemia via PI3K/AKT-dependent activation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in …
  1411. Pinocembrin provides mitochondrial protection by the activation of the Erk1/2-Nrf2 signaling pathway in SH-SY5Y neuroblastoma cells exposed to paraquat
  1412. Celastrol protects RPE cells from oxidative stress-induced cell death via activation of Nrf2 signaling pathway
  1413. Nrf2 knockout: The effect on neurological dysfunction and the activation of glial cells of mice after brain injury.
  1414. Alleviated Oxidative Damage by Taraxacum officinale through the Induction of Nrf2-MAPK/PI3K Mediated HO-1 Activation in Murine Macrophages RAW 264.7 Cell …
  1415. Maresin 1 mitigates renal ischemia/reperfusion injury in mice via inhibition of the TLR4/MAPK/NF-κB pathways and activation of the Nrf2 pathway
  1416. Chronic activation of hepatic Nrf2 has no major effect on fatty acid and glucose metabolism in adult mice
  1417. Epigallocatechin-3-gallate attenuates microcystin-LR-induced apoptosis in human umbilical vein endothelial cells through activation of the NRF2/HO-1 pathway
  1418. Puerarin protects endothelial progenitor cells from damage of angiotensin II via activation of ERK1/2‑Nrf2 signaling pathway
  1419. Redox signaling in ischemic postconditioning protection involves PKCε and Erk1/2 pathways and converges indirectly in Nrf2 activation
  1420. Zinc L-carnosine suppresses inflammatory responses in lipopolysaccharide-induced RAW 264.7 murine macrophages cell line via activation of Nrf2/HO-1 signaling …
  1421. Artocarmitin B enhances intracellular antioxidant capacity via activation of Nrf2 signaling pathway in human lung epithelial cells
  1422. Proteasome inhibitor-induced IκB/NF-κB activation is mediated by Nrf2-dependent light chain 3B induction in lung cancer cells
  1423. Cytoprotective effect of Makgeolli lees on paraquat induced oxidative stress in A549 cells via activation of NRF2 and antioxidant genes
  1424. Prevention effect of Ligusticum chuanxiong extraction against oxidative stress injury induced by myocardial ischemia through activation of Nrf2 signaling pathway
  1425. A red pumpkin seed extract reduces melanosome transfer to keratinocytes by activation of Nrf2 signaling
  1426. Berberine upregulates P-glycoprotein in human Caco-2 cells and in an experimental model of colitis in the rat via activation of Nrf2-dependent mechanisms
  1427. Fibroblast growth factor 19 protects the heart from oxidative stress-induced diabetic cardiomyopathy via activation of AMPK/Nrf2/HO-1 pathway
  1428. Pilot-scale produced fermented lentil protects against t-BHP-triggered oxidative stress by activation of Nrf2 dependent on SAPK/JNK phosphorylation
  1429. Mangiferin upregulates glyoxalase 1 through activation of Nrf2/ARE signaling in central neurons cultured with high glucose
  1430. BQ123 stimulates skeletal muscle antioxidant defense via Nrf2 activation in LPS-treated rats
  1431. Melaleuca alternifolia Induces Heme Oxygenase-1 Expression in Murine RAW264.7 Cells through Activation of the Nrf2-ARE Pathway
  1432. Activation of NRF2 by dexamethasone in ataxia telangiectasia cells involves KEAP1 inhibition but not the inhibition of p38
  1433. … 1 ameliorates the neuronal apoptosis and oxidative stress induced by oxygen-glucose deprivation/reoxygenation through activation of Nrf2/HO-1 signaling
  1434. Sake lees hydrolysate protects against acetaminophen-induced hepatotoxicity via activation of the Nrf2 antioxidant pathway
  1435. Effect of repeated daily dosing with 2, 4-dinitrochlorobenzene on glutathione biosynthesis and Nrf2 activation in reconstructed human epidermis
  1436. Genistein attenuates di‑(2‑ethylhexyl) phthalate-induced testicular injuries via activation of Nrf2/HO‑1 following prepubertal exposure
  1437. N-butyl-α-D-fructofuranoside isolated from Ulmus davidiana enhances Nrf2 activity through activation of JNK
  1438. Mitochondrial permeabilization without caspase activation mediates the increase of basal apoptosis in cells lacking Nrf2
  1439. Fraxetin induces heme oxygenase-1 expression by activation of Akt/Nrf2 or AMP-activated protein kinase α/Nrf2 pathway in HaCaT cells
  1440. Nrf2 activation by curcumin improves exercise performance of mice with chronic heart failure
  1441. The role of Nrf2 in primary human CD4 T cell activation and differentiation
  1442. Nrf2 activator corosolic acid meliorates alloxan induced diabetic nephropathy in mice
  1443. Sirt1 activation prevents anti-Thy 1.1 mesangial proliferative glomerulonephritis in the rat through the Nrf2/ARE pathway
  1444. … inhibits TNF-α-induced angiogenesis and ROS generation through suppression of MMP-9/NF-κB signaling and activation of Nrf2-mediated antioxidant genes …
  1445. Plumbagin ameliorates memory dysfunction in streptozotocin induced Alzheimer’s disease via activation of Nrf2/ARE pathway and inhibition of β-secretase
  1446. Fusaric acid induces NRF2 as a cytoprotective response to prevent NLRP3 activation in the liver derived HepG2 cell line
  1447. Gintonin, a ginseng-derived ingredient, as a novel therapeutic strategy for Huntington’s disease: Activation of the Nrf2 pathway through lysophosphatidic acid …
  1448. 1, 4-Naphthoquinone, a pro-oxidant, ameliorated radiation induced gastro-intestinal injury through perturbation of cellular redox and activation of Nrf2 pathway
  1449. HO-1/EBP interaction alleviates cholesterol-induced hypoxia through the activation of the AKT and Nrf2/mTOR pathways and inhibition of carbohydrate …
  1450. Epicatechin isolated from Tripterygium wilfordii extract reduces tau-GFP-induced neurotoxicity in zebrafish embryo through the activation of Nrf2
  1451. Protective effects of tyrosol against LPS-induced acute lung injury via inhibiting NF-κB and AP-1 activation and activating the HO-1/Nrf2 pathways
  1452. Saeng-Kankunbi-Tang (生肝健脾汤) protects liver against oxidative damage through activation of ERK/Nrf2 pathway
  1453. Possible involvement of transcriptional activation of nuclear factor erythroid 2-related factor 2 (Nrf2) in the protective effect of caffeic acid on paraquat-induced …
  1454. In vitro biotransformation of the Nrf2 activator bardoxolone: formation of an epoxide metabolite that undergoes two novel glutathione-mediated metabolic pathways …
  1455. Research progress of small molecule activators in Keapl-Nrf2-ARE signaling pathway
  1456. Utilization of the Ability to Induce Activation of the Nuclear Factor (Erythroid‐derived 2)‐like Factor 2 (Nrf2) to Assess Potential Cancer Chemopreventive Activity of …
  1457. … revitalizes Amyloid beta (25–35)-induced and organophosphate pesticides pestered neurotoxicity in SH-SY5Y and IMR-32 cells via activation of APE1 and Nrf2
  1458. S-1-propenylmercaptocysteine protects murine hepatocytes against oxidative stress via persulfidation of Keap1 and activation of Nrf2
  1459. 17-β estradiol exerts anti-inflammatory effects through activation of Nrf2 in mouse embryonic fibroblasts
  1460. Protective effect of Nrf2 activation by curcumin against lead-induced toxicity and apoptosis in SH-SY5Y cells
  1461. Activation of the molecular and functional effects of Nrf2 against chronic iron oxide nanorod overload-induced cardiotoxicity
  1462. Protective effect of Rumenic acid rich cow’s milk against colitis is associated with the activation of Nrf2 pathway in a murine model
  1463. Docosahexaenoic acid induces expression of heme oxygenase-1 and NAD (P) H: quinone oxidoreductase through activation of Nrf2 in human mammary epithelial …
  1464. Activation of Nrf2 translation by a Keap1 independent mechanism
  1465. Neuroligin-3 protects retinal cells from H2O2-induced cell death via activation of Nrf2 signaling
  1466. Thymus vulgaris alleviates UVB irradiation induced skin damage via inhibition of MAPK/AP‐1 and activation of Nrf2‐ARE antioxidant system
  1467. … cells (HTMCs) via the phosphatidylinositol 3-kinase (PI3K)/serine/threonine kinase (Akt)-mediated factor-E2-related factor 2 (Nrf2) signaling activation
  1468. Cinnamaldehyde attenuates high glucose-induced oxidative stress and endothelial dysfunction as an Nrf2 activator
  1469. Phytochemical combinations modulate the activation of Nrf2 and expression of SOD in pancreatic cancer cells more efficiently than single plant components
  1470. Nrf2-Mediated System xc− Activation in Astroglial Cells Is Involved in HIV-1 Tat-Induced Neurotoxicity
  1471. IL-17 enhances oxidative stress in hepatocytes through Nrf2/keap1 signal pathway activation
  1472. Response to comment on “NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis”
  1473. Ligustrazine nanoparticles nano spray’s activation on Nrf2/ARE pathway in oxidative stress injury in rats with postoperative abdominal adhesion
  1474. Nrf2 activation mediates tumor-specific hepatic stellate cells-induced DIgR2 expression in dendritic cells
  1475. Activation of imidazoline I1 receptor by moxonidine regulates the progression of liver fibrosis in the Nrf2-dependent pathway
  1476. Activation of the nuclear erythroid 2-related factor 2 antioxidant responsive element (Nrf2-ARE) signaling pathway alleviates acute graft-versus-host disease …
  1477. Inhibition of early biochemical defects in prodromal Huntington’s disease by simultaneous activation of Nrf2 and elevation of multiple micronutrients
  1478. Ethyl 2, 4-dicarboethoxy pantothenate, a derivative of pantothenic acid, prevents cellular damage initiated by environmental pollutants through Nrf2 activation
  1479. Hepatoprotective effect of 7-hydroxycoumarin against methyl glyoxal toxicity via activation of Nrf2
  1480. Chronic arsenic-induced metabolic syndrome: A role for prolonged Nrf2 activation and mitochondrial metabolism
  1481. Protective function of pyridoxamine on retinal photoreceptor cells via activation of the p‑Erk1/2/Nrf2/Trx/ASK1 signalling pathway in diabetic mice
  1482. 4-Nitrophenol induces activation of Nrf2 antioxidant pathway and apoptosis of the germ cells in rat testes
  1483. Schisandra chinensis Stem Ameliorates 3-Nitropropionic Acid-Induced Striatal Toxicity via Activation of the Nrf2 Pathway and Inhibition of the MAPKs and NF …
  1484. Activation of NRF2 signaling in breast cancer stem cell-enriched population
  1485. Protective effects of ursolic acid on osteoblastic differentiation via activation of IER3/Nrf2
  1486. The Immune Response to Influenza is Suppressed by the Synthetic Food Additive and Nrf2 Activator, tert‐butylhydroquinone (tBHQ)
  1487. Over-activation of the Nrf2-antioxidant response element pathway in hepatocytes decreases hepatic ischemia reperfusion injury in mice
  1488. Hepatoprotective effect of Paeoniae radix via Nrf2 activation
  1489. Mycosporine-like amino acid activation of the Keap1-Nrf2 pathway
  1490. Thai herbal antipyretic 22 formula (APF22) inhibits UVA‐mediated melanogenesis through activation of Nrf2‐regulated antioxidant defense
  1491. MiR‐21‐Mediated Suppression of Smad7 Induces TGF β1 and Can Be Inhibited by Activation of Nrf2 in Alcohol‐Treated Lung Fibroblasts
  1492. … from Rhizoma Panacis Majoris attenuate myocardial ischemia/reperfusion injury via the activation of the Sirt1/Foxo1/Pgc-1α and Nrf2/antioxidant defense pathways in …
  1493. Evaluation of a new pharmacologic strategy for Nrf2 activation for retinal ischemia-reperfusion injury
  1494. Src subfamily kinases regulate nuclear export and degradation of transcription factor Nrf2 to switch off Nrf2-mediated antioxidant activation of cytoprotective gene …
  1495. Effects of Schisandrae chinensis fructus induced CYPs and Nrf2 activation on acute liver injury induced by acetaminophen
  1496. … analysis in peripheral blood cells of patients with hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC): identification of NRF2 pathway activation
  1497. Publisher Correction: Valproic Acid Sensitizes Hepatocellular Carcinoma Cells to Proton Therapy by Suppressing Nrf2 Activation
  1498. Involvement of Oxidative Stress, Inflammation, and Glutamate in Ototoxici-ty, and their Attenuation by Simultaneous Activation of Nrf2 and Elevation of …
  1499. Activation of Nrf2 Target Genes by Aged Garlic Extract in THP‐1 Macrophages: Regulation by Glutathione Depletion
  1500. Roasted coffee induction of aldo-keto reductase 1C3 expression in LNCaP human prostate cancer cells is associated with Nrf2 activation
  1501. A new approach for skin-derived precursors to ameliorate skin photodamage through activation of nrf2 signaling pathway
  1502. Nrf2 activation but not vitamin C treatment promotes proteostatic maintenance during an oxidative challenge
  1503. Identification and Structural Analysis of New Nrf2 Activators by Mechanism‐Based Chemical Transformation of 15‐Deoxy‐Δ12, 14‐PGJ2
  1504. The Nrf2 activators tBHQ and CDDO-Im have both Nrf2-dependent and–independent effects on human Jurkat T cell activation, as determined by CRISPR-Cas9 gene …
  1505. FO006 THE NRF2 ACTIVATOR BARDOXOLONE METHYL INHIBITS CYST FORMATION, REDUCES INFLAMMATION, AND IMPROVES MITOCHONDRIAL …
  1506. Nrf2 activation and fetal hemoglobin induction in sickle cell disease
  1507. A pan-ErbB family inhibitor, AF8c, promotes apoptosis by DR5/Nrf2 activation via ROS in colorectal cancer cells
  1508. Simultaneous Activation of Nrf2 and Elevation of Dietary and Endogenous Antioxidants for Prevention and Improved Management of Parkinson’s Disease
  1509. Abstract TP573: Nrf2 Activation With Sulforaphane Reduces Post-Stroke Cognitive Impairment in Mice
  1510. Dual Activation of NRF2 in Multiple Myeloma and Bone Marrow Mesenchymal Stromal Cells Regulates Chemotherapy Resistance
  1511. Single-cell RNA-sequencing of Herpes simplex virus 1-infected cells identifies NRF2 activation as an antiviral program
  1512. Zinc, sulphate preconditioning alleviates rat myocardial hypoxia reoxygenation injury in vitro: activation of the Nrf2/ARE signaling pathway
  1513. Genetic activation of NRF2 By KEAP1 inhibition induces fetal hemoglobin expression and triggers anti-oxidant stress response in erythroid cells
  1514. Luteolin 5-O-glucoside from Korean milk thistle, Cirsium maackii, exhibits anti-inflammatory activity via activation of the Nrf2/HO-1 pathway
  1515. NRF2 activation via PI3K/AKT/mTOR/RPS6 causes resistance to anti-HER2 agents among HER2 amplified gastric cancer
  1516. R970, A Selective Activator of Nrf2, is Efficacious in a Murine Model of Multiple Sclerosis
  1517. Activation of nuclear factor erythroid 2-related (Nrf2) system as a novel therapeutic approach in COPD
  1518. Nrf2 But Not Autophagy Activation Is Associated with Resistance to EGFR Inhibitor‐Induced Lung Tumor Cell Apoptosis
  1519. … B, a nutmeg lignan, in nonalcoholic fatty liver disease: Anti‐lipogenic and hepatocyte‐protective effects through AMP‐activated protein kinase and Nrf2 activation
  1520. Application of Nrf2 activators in the treatment of Alzheimer′ s disease
  1521. 213 Nrf2 activation improves both hyperpolarization-and NO-mediated responses in penile vasculature from patients with erectile dysfunction
  1522. Lactucopicrin suppresses oxidative stress initiated by scopolamine‐induced neurotoxicity through activation of NRF2 pathway
  1523. Effect of PI3K-Mediated Nrf2 Phosphorylated Activation in Quercetin in Inhibiting Clivorine-Induced Hepatotoxicity
  1524. Correction to: Sulforaphane protects granulosa cells against oxidative stress via activation of NRF2-ARE pathway
  1525. The Protective Effect of Nrf2 Activation in Cardiovascular Disease
  1526. Protective effects of sulforaphane on STZ‐induced diabetic retinopathy via activation of Nrf2/HO‐1 antioxidant pathway and inhibition of NADPH oxidase
  1527. Quantifying synergy for hormetic compounds using the dose-equivalence/zero-interaction (DE/ZI) method: Nrf2/antioxidant response element pathway activation
  1528. … exert anti-photoaging effects on primary dermal fibroblasts and mouse skin exposed to UVA in association with activation of Nrf2-mediated antioxidant response
  1529. Chicoric acid prevents methotrexate-induced kidney injury by suppressing NF-κB/NLRP3 inflammasome activation and up-regulating Nrf2/ARE/HO-1 signaling.
  1530. A ROLE FOR NRF2 ACTIVATION IN DELAYED AGING: EVIDENCE FROM BENCH TO BEDSIDE
  1531. Inhibition of ROS-Induced Nrf2 antioxidant pathway activation may explain synergy between venetoclax and hypomethylating agents against acute myeloid …
  1532. MP369 D PINITOL ALLEVIATES CYCLOSPORINE-INDUCED RENAL FIBROSIS VIA THE ACTIVATION OF SIRT1 AND NRF2 ANTIOXIDANT PATHWAYS
  1533. Nrf2 activators as therapy for acute radiation dermatitis
  1534. Characterization of the Molecular Mechanisms of Xenobiotic-Induced NRF2 Activation for Disease Prevention and Intervention
  1535. Effect of Treatment with a NRF2 Activator on In Vivo Proteostasis in Mice
  1536. Beneficial Effects of Nrf2 Activation on Vascular Function and Detrimental Effects of Nrf2 Activation on Renal Function in Dahl Salt‐Sensitive Rats
  1537. A novel Nrf2 activator RS9 protects ARPE-19 cells from oxidative stress induced by NaIO3 via autophagic pathway
  1538. Regular intake of high-fat diet exacerbates oxidative stress-mediated DNA hypermethylation and activation of Nrf2-Keap1 signaling in UVB-induced skin tumors in …
  1539. The effects of Nrf2 activator in a rodent model of anterior ischemic optic neuropathy (rAION)
  1540. Evaluation of a novel phytochemical Nrf2 activator on cytoprotective gene expression and proteostasis in vivo
  1541. GW27-e1152 Activation of cannabinoid receptor II-CB2 ameliorates cardiac fibrosis after myocardial infarction via Nrf2-mediated inhibition of TGFβ-1/Smad3 pathway
  1542. Nrf2 activation skews murine and human CD4 T cell differentiation towards a Th2 phenotype
  1543. Inflammatory stress induces a biphasic Nrf2 activation in neuronal cells
  1544. Restoration of Microglial Transporter Expression by Nrf2 Activation
  1545. Rescuing Alzheimer’s Disease-Related Memory Impairment Through Nrf2 Activation
  1546. The Role Of Aldo-Keto Reductases And Nrf2 Signaling In The Metabolic Activation Of Nitrated Polycyclic Aromatic Hydrocarbons
  1547. The Phytochemistry of Selected Ancistrocladus and Monsonia Species and their Anti-Pancreatic Cancer and Nrf2 Activator Properties
  1548. The Nrf2 activator methyl bardoxolone exacerbates mitochondrial dysfunction in palmitate-treated breast cancer cells
  1549. Interactions between Nrf2 Activation and Glutathione in the Maintenance of Redox Homeostasis
  1550. NRF2 activator RS9 protects corneal epithelium from cell damage in dry eye models
  1551. Activation of Nrf2 by Lipid Peroxidation Products
  1552. A therapeutic strategy for psoriasis: STAT3 and NF-κB inhibition by tussilagonone as an Nrf2 activator in keratinocytes
  1553. Induction of Endogenous Nrf2 Activation in the Retina Partially Protects from Oxidative Stress and Inflammation
  1554. The Nrf2 activator, tBHQ, inhibits IL-2 production by human T cells in a largely Nrf2-independent manner
  1555. GW29-e0001 Cinnameldehyde Attenuated Endothelial Dysfunction through Nrf2 Activation as a TRPA1 Agonist
  1556. A0625 Cinnameldehyde Attenuated Endothelial Dysfunction through Nrf2 Activation as a TRPA1 Agonist
  1557. Nrf2 Activation Rescues Dendritic Pathology in hPSC‐Derived And Primary Neuron Based Models of Parkinson’s Disease
  1558. Nature‐inspired Nrf2 activators in retinal pigment epithelial cells: a source for therapeutics in age‐related macular degeneration
  1559. Dengue virus infection causes Nrf2 activation to induce CLEC5A-facilitated TNF-α production in mononuclear phagocytes
  1560. Novel regulators of Nrf2 activation relevant for drug-induced liver injury identified by a RNAi-based high throughput microscopy screening
  1561. Activated SIRT1 and SIRT6 by Nrf2 Activator Attenuated Cisplatin-Induced Acute Nephrotoxicity in Mice
  1562. Effect of NRF2 Activation on Endothelial Function, Microvessel Density, and Gene Expression in Rats fed High Salt Diet
  1563. Targeting the Nrf2/NLRP3-Inflammasome Axis with Nrf2 Activators Lessens Macrophage Oxidative Stress and Cytokine Production, and Improves End Points …
  1564. Involvement of lipid rafts on Nrf2 activation induced by quercetin
  1565. BENEFICAL EFFECTS OF BARDOXOLONE METHYL, A NRF2 ACTIVATOR, ON ACETAMINOPHEN-INDUCED ACUTE NEPHROTOXICITY IN RATS
  1566. Identification and Structural Analysis of New Nrf2 Activators by Mechanism-Based Chemical Transformation of 15-Deoxy-Δ12, 14-PGJ2
  1567. Sulforaphane Induces Colorectal Cancer Cell Proliferation through Nrf2 Activation in a p53‐Dependent Manner
  1568. Nrf2 Activation Attenuates Hemolysis but Promotes Pulmonary Vascular Dysfunction in Sickle Mice
  1569. Diallyl Trisulfide Prospectively Retrieves Arsenic Induced Lung Oxidative Stress, Inflammation Through the Activation of Nrf2/HO-1 Signaling
  1570. The Role of Nrf2 in the Activation of Primary CD4 T Cells from Mice and Humans
  1571. … : Ischemic Preconditioning Improves Long-Term Outcomes and Preserves Blood-Brain Barrier After Ischemic Stroke via Oxidative Signaling and Nrf2 Activation
  1572. Protandim® Treatment Causes Reversible Nuclear Translocation of Nrf2 and Activation of the Antioxidant Response Element
  1573. 2′-O-Galloylhyperin Isolated From Pyrola incarnata Fisch. Attenuates LPS-Induced Inflammatory Response by Activation of SIRT1/Nrf2 and Inhibition of the …
  1574. Activation of Nrf2 by 18α-GA affects proliferation of adult neural stem cells
  1575. Abstract B16: Activation of NRF2 and adaptive resistance to chemotherapy
  1576. The Nrf2 activator dimethyl fumarate inhibits acute graft-versus-host disease with retention of graft-versus-tumor effects
  1577. Muscle contractile activity‐mediated regulation of antioxidant enzymes in oxidative muscle requires p62/SQSTM1 phosphorylation‐induced Nrf2 activation
  1578. Spatio-temporal analysis of the Nrf2 activation in transgenic reporter mouse fed with high dosage of saturated or unsaturated fatty acids using in vivo bioluminescent …
  1579. FOXQ1 promotes proliferation and metastasis of epithelial ovarian cancer via activation of SIRT1/NRF2 signaling pathway
  1580. The Neuroprotective Effect of a Synthetic Chalcone Analog Through the Activation of Akt/Erk/Nrf2 Signaling
  1581. Non-electrophilic activation of the Nrf2 pathway ameliorated experimental Nonalcoholic Steatohepatitis ADD YOUR LOGOS
  1582. … to “Brain ischemic preconditioning protects against ischemic injury and preserves the blood-brain barrier via oxidative signaling and Nrf2 activation”[Redox Biol. 17 …
  1583. … /Zero-Interaction (DE/ZI) Method for Quantifying Small Molecule Interactions: Nrf2/Antioxidant Response Element Pathway Activation by Sulforaphane and a …
  1584. Selective Inhibition Of Hdac3 Prevents Diabetic Cardiomyopathy In Ove26 Mice Via Mir-200a-mediated Nrf2 Activation
  1585. Fermented black radish (FBR) ameliorates hepatic lipid accumulation by transcriptional factor Nrf2 activation in HepG2 cells
  1586. KEAP1 gene editing using CRISPR/Cas9 for therapeutic NRF2 activation in human T cells
  1587. Correction to: A Dual AMPK/Nrf2 Activator Reduces Brain Inflammation After Stroke by Enhancing Microglia M2 Polarization by Wang Y, Huang Y, Xu Y, Ruan W …
  1588. Effects of PKC activation on expression of Nrf2 in rabbit RPE cells
  1589. 24-hydroxycholesterol as Nrf2 activator able to enhance tau clearance for treatment of Alzheimer’s disease
  1590. Oncogenic activation of Nrf2 by specific knockout of Nrf1α that acts as a dominant tumor repressor
  1591. … latifolin isolated from Dalbergia odorifera attenuates hypoxia-reoxygenation injury by reactive oxygen species scavenging and Nrf2 activation in H9c2 cardiomyocyte
  1592. … Prognosis Acute Myeloid Leukemia and Suggests a Novel Therapeutic Strategy By Combined Bromodomain Inhibition and Forced NRF2 Pathway Activation
  1593. Corrigendum to” Nrf2 activators from Glycyrrhiza inflata and their hepatoprotective activities against CCl4-induced liver injury in mice”[Bioorg. Med. Chem. 25 (20) …
  1594. A novel role of topical iodine in skin: Activation of the Nrf2 pathway.
  1595. … sativus) intake provides nutritional preconditioning against myocardial ischemia-reperfusion injury in wild type and Apo-E (−/−) mice: involvement of Nrf2 activation
  1596. Synthesis and biological activity of chalcone derivatives as potent activators of Nrf2
  1597. Xiaochaihutang attenuates liver fibrosis in rats through activation of Nrf2 pathway
  1598. C15 is actionable drug target for anti-arthritis via activation Nrf2 signaling
  1599. Activation Of Nrf2 Appears To Prevent Alcohol-Mediated Induction Of TGFβ1 By Suppressing MiR-21 And Restoring Smad7 Expression
  1600. Brg1 Protects Cardiomyocytes Against Oxidative Damage Through Activation of the Nrf2 Signaling Pathway in Acute Myocardial Infarction
  1601. Activation of the Transcription factor Nrf2 involved in human trophoblast syncytialization (in vitro study)
  1602. NRF2 drives glioma malignancy through transcriptional activation of an important oncogenic mechanism
  1603. Ameliorative effect of esculetin against streptozotocin-induced experimental dementia via activation of Nrf2/HO-1 axis and suppression of NF-kappa B
  1604. Inhibition of neuroinflammation by thymoquinone requires activation of Nrf2/ARE signalling Ravikanth Velagapudi1, 4, Asit Kumar2, 5, Harsharan S Bhatia2, 3 …
  1605. Nrf2 knockout: The effect on neurological dysfunction and the activation of glial cells of mice after brain injury
  1606. Cardiac-Specific Constitutive Activation of Nrf2 Induces a Stable Reductive State in Mice
  1607. RPS6 through the activation of NRF2 causes resistance to antiHER2 drugs in HER2 amplified gastric cancer (GC) models
  1608. Protective effects of novel derivatives of vitamin D3 and lumisterol against UVB-induced damage in human keratinocytes involve activation of Nrf2 and P53 defense …
  1609. Dr. Jekyll and Mr. Hyde: Reactive Oxygen Species Play Opposing Roles in Electrophile-Mediated Nrf2/Antioxidant Response Element Activation
  1610. Activation of Nrf2 suppresses inflammation and semaphorin 6A signaling in oxygen-induced retinopathy
  1611. Cardiac-specific Constitutive Activation of Nrf2 Induces Reductive Stress and Pathological Cardiac Remodeling
  1612. THU0053 Selective activation of an AMPK-CREB-NRF2-dependent pathway by celecoxib induces vasculoprotective genes and mitigates against cardiovascular risk
  1613. Corrigendum to” JWA antagonizes paraquat-induced neurotoxicity via activation of Nrf2″[Toxicol. Lett. 277 (August)(2017) 32-40]
  1614. … Article Dietary Lycium barbarum Polysaccharide Induces Nrf2/ARE Pathway and Ameliorates Insulin Resistance Induced by High-Fat via Activation of PI3K/AKT …
  1615. Activation of Nrf2 attenuates pulmonary vascular remodeling via inhibiting endothelial-to-mesenchymal transition
  1616. Retraction: Phosphorylation and dephosphorylation of tyrosine 141 regulate stability and degradation of INrf2. A NOVEL MECHANISM IN NRF2 ACTIVATION.
  1617. Corrigendum: Investigation of Nrf2, AhR and ATF4 activation in toxicogenomic databases
  1618. Pharmacological Activation of Nrf2 by Sesamol Stimulates Ucp1 Induction in Adipocytes and Increases Energy Expenditure in Mice
  1619. Downregulated Microrna-27b Attenuates Lipopolysaccharide-Induced Acute Lung Injury Via Activation of Nrf2 and Inhibition of NF-κB Signaling Pathways
  1620. Correction to: Nrf2-Mediated System xc − Activation in Astroglial Cells Is Involved in HIV-1 Tat-Induced Neurotoxicity
  1621. Role of ROS in emulsified isoflurane postconditioning-induced activation of Nrf2/ARE signaling pathway in rat cardiomyocytes
  1622. Activation of the proteasome machinery by NRF2/mutant p53 axis and its therapeutic implications for triple negative breast cancer
  1623. Glutathione (GSH) distribution by quantitative MALDI imaging in reconstructed human skin upon activation of GSH biosynthesis by Nrf2 pathway activator
  1624. Role of ROS in emulsified isoflurane postconditioning-induced promotion of Nrf2∕ ARE signaling pathway activation in rats with myocardial injury
  1625. Retinoid X Receptor´ s activation modulates a crosstalk between NrF2 and NFkB pathway in retinal pigment epithelium cells upon H2O2 treatment
  1626. A defect in the Nrf2/HO-1 pathway and Nox2 activation results in regulatory T cell mitochondrial dysfunction in alcohol related cirrhosis
  1627. A28 EXOSOMES AND MICRORNA: Activation Of Nrf2 Appears To Prevent Alcohol-Mediated Induction Of Tgfβ1 By Suppressing Mir-21 And Restoring Smad7 …
  1628. Rodgersia podophylla Leaves Suppress Inflammatory mediators through activation of Nrf2/HO-1 signaling, and inhibition of LPS-induced NF-κB and MAPKs signaling …
  1629. Phosphorylation and dephosphorylation of tyrosine 141 regulate stability and degradation of INrf2. A NOVEL MECHANISM IN NRF2 ACTIVATION.
  1630. Phosphorylation and dephosphorylation of tyrosine 141 regulate stability and degradation of INrf2. A novel mechanism in Nrf2 activation.
  1631. Tsg101 Protects the Heart Against Ischemia/Reperfusion Injury Through Aggregation of P62 and Activation of NRF2 Signaling
  1632. Activated microglia enhance astroglial neuroprotective pentose-phosphate pathway through the activation of the Keap1/Nrf2 system by nitric oxide
  1633. Activation of NF-Kappa B-p62-NRF2 Signaling Supports the Survival of CLL Cells That Express High Levels of ROR1
  1634. … sulfide ameliorates learning memory impairment in APP/PS1 transgenic mice: A novel mechanism mediated by the activation of Nrf2″[Pharmacol. Biochem. Behav …
  1635. 5-aminolevulinic acid exerts renoprotective effect via Nrf2 activation in murine rhabdomyolysis-induced acute kidney injury
  1636. … Effect of Sageretia theezans against the Production of Pro-Inflammatory Mediators through the Inhibition of NF-κB and MAPK, and Activation of Nrf2/HO-1 Signaling …
  1637. … -induced INrf2 (Keap1) tyrosine 85 phosphorylation controls the nuclear export and degradation of the INrf2–Cul3–Rbx1 complex to allow normal Nrf2 activation and …
  1638. EF Derived from Human Placental Mesenchymal Stem Cells Improves Premature Ovarian Insufficiency Via NRF2/HO-1 Activation
  1639. Artemether Activation of AMPK/GSK3β (ser9)/Nrf2 Signaling Confers Neuroprotection towards β-Amyloid-Induced Neurotoxicity in 3xTg Alzheimer’s Mouse Model
  1640. Stromal Cell-derived Factor-1 Prevents From Diabetic Cardiomyopathy via Cxcr7/ampk-mediated Nrf2 Activation in Type 2 Diabetic Mice
  1641. Intracellular redox status determines self-renewal activity of breast cancer stem-like cells through activation of Nrf2-mediated FoxO3a-Bmi-1 signaling
  1642. … /Food Microbiology: Cytoprotective Effect of Makgeolli Lees on Paraquat Induced Oxidative Stress in A549 Cells via Activation of NRF2 and Antioxidant Genes
  1643. Suppression of microRNA-128 attenuates high glucose-induced podocyte apoptosis through activation of Nrf2-ARE signaling pathway
  1644. Citrus polymethoxyflavones (PMFs) inhibit 12‐O‐tetradecanoylphorbol 13‐acetate (TPA) induced mouse skin JB6 P+ cell transformation through the activation of Nrf2 …
  1645. : Anthraquinone and naphthopyrone glycosides from Cassia obtusifolia seeds exhibit hepatoprotective activity via activation of the Nrf2/HO-1 and modulation of JNK …
  1646. Involvement of Nrf2-mediated heme oxygenase-1 expression in anti-inflammatory action of chitooligosaccharides through MAPK activation in murine macrophages
  1647. Role of Protein Kinases on Activation of Nrf2/Keap1/ARE Signaling Pathway by Sulforaphane and Licochalcone A in HCT116 Human Colon Cancer Cells
  1648. Andrographolide Activates Keap1/Nrf2/ARE/HO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by A𝛽42 through Nrf2-Related Inflammatory …
  1649. … serratifolium suppresses RANKL-induced osteoclast differentiation and oxidative stress through inhibition of NF-κB and activation of the Nrf2/HO-1 signaling pathway
  1650. … Differential regulation of innate immune cytokine production through pharmacological activation of Nuclear Factor-Erythroid-2-Related Factor 2 (NRF2) in burn patient …
  1651. MP45-05 ACTIVATION OF NRF2 IMPROVES ENDOTHELIAL FUNCTION IN CORPUS CAVERNOSUM FROM AGED RATS AND IN CORPUS CAVERNOSUM AND …
  1652. … ) ATTENUATES CPP-INDUCED CALCIFICATION OF VASCULAR SMOOTH MUSCLE CELLS VIA ACTIVATION OF THE KEAP1 NRF2 NQO1 SIGNALING PATHWAY
  1653. Angiotensin-(1-7) attenuates endothelial cell senescence via klotho and Nrf2 activation
  1654. Thioredoxin related protein of 14 kDa (TRP14, TXNDC17) represses Nrf2 and NFκB activities and augments HIF activation
  1655. Protective effects of Zhen-Gan Xi-Feng decoction-containing serum on 6-OHDA-induced oxidative stress in PC12 cells through Nrf2-ARE pathway activation
  1656. Epigallocatechin-3-gallate as an activator of Nrf2/ARE signaling pathway: a review
  1657. 60 Quercetin protects bovine pre-implantation embryos against oxidative stress via activation of Nrf2 signaling pathway
  1658. 516-P: Preventive Effect of Sulforaphane on Type 2 Diabetes-Induced Diabetic Nephropathy via AMPK-Mediated Activation of Glucose/Lipid Metabolism and Nrf2 …
  1659. 372-P: Activation of the Nrf2 Pathway Provides Protection against Hypoglycaemia-Induced Cognitive Impairment in a Rodent Model of Type 1 Diabetes
  1660. 613-P: Preventive Effect of Sulforaphane on Type 2 Diabetes-Induced Diabetic Cardiomyopathy via AMPK-Mediated Activation of Glucose/Lipid Metabolism and Nrf2 …
  1661. Abstract P344: Nuclear Factor E2-related Factor 2 (nrf2) Causes Early Microvascular Endothelial Dysfunction and Increased Adma by Activation of the Cox2/tp …
  1662. … (Chinese mystery snail) alcalase hydrolysate attenuates inflammatory responses in LPS-stimulated Raw 264.7 macrophages via the activation of Nrf2/HO-1 signaling
  1663. … CHANNEL BLOCKER ATTENUATES UNILATERAL URETERAL OBSTRUCTION-INDUCED RENAL INTERSTITIAL FIBROSIS VIA ACTIVATION OF THE NRF2 …
  1664. Thai herbal antipyretic 22 formula inhibits melanogenesis through activation of NRF2-regulated antioxidant defense in UVA-irradiated B16 melanoma cells
  1665. … toS-Allyl cysteine protects against 6-hydroxydopamine-induced neurotoxicity in the rat striatum: involvement of Nrf2 transcription factor activation and modulation of …
  1666. … 1 inducer (CoPP) protects human cardiac stem cells against apoptosis through activation of the extracellular signal-related kinase (ERK)/NRF2 signaling pathway and …
  1667. … of hepatitis B surface antigen and mutated alpha-1 antitrypsin promotes the development of liver disease via autophagy overload and activation of p62-mTOR-Nrf2 …
  1668. Hesperetin induces glyoxalase 1 enhancement in SH-SY5Y cells cultured with high glucose via Nrf2/ARE activation.
  1669. Paeonol attenuates high glucose-induced expression of FN and ICAM-1 by promoting the activation of Nrf2/ARE pathway via upregulation of Sirt1 in GMCs
  1670. An update of Nrf2 activators and inhibitors in cancer prevention/promotion
  1671. The hormetic dose-response mechanism: Nrf2 activation
  1672. The Nrf2 activator (DMF) and covid-19: is there a possible role?
  1673. Nrf2 Activator PB125® as a Potential Therapeutic Agent against COVID-19
  1674. Can activation of NRF2 be a strategy against COVID-19?
  1675. COPD lung studies of Nrf2 expression and the effects of Nrf2 activators
  1676. Potential therapeutic effects of Nrf2 activators on intracranial hemorrhage
  1677. NRF2 activation promotes aggressive lung cancer and associates with poor clinical outcomes
  1678. Nrf2 activation in chronic kidney disease: promises and pitfalls
  1679. The pivotal role of Nrf2 activators in adipocyte biology
  1680. Nrf2 activation through the inhibition of Keap1–Nrf2 protein–protein interaction
  1681. Nrf2 activator via interference of Nrf2-Keap1 interaction has antioxidant and anti-inflammatory properties in Parkinson’s disease animal model
  1682. Recent progress in the development of small molecule Nrf2 activators: a patent review (2017-present)
  1683. Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis
  1684. Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response
  1685. Systems biology reveals anatabine to be an NRF2 activator
  1686. Role of microgliosis, oxidative stress and associated neuroinflammation in the pathogenesis of Parkinson’s disease: The therapeutic role of Nrf2 activators
  1687. NRF2 activation promotes the recurrence of dormant tumour cells through regulation of redox and nucleotide metabolism
  1688. Nrf2 activation and its coordination with the protective defense systems in response to electrophilic stress
  1689. Combination of autophagy and NFE2L2/NRF2 activation as a treatment approach for neuropathic pain
  1690. A review on herbal Nrf2 activators with preclinical evidence in cardiovascular diseases
  1691. Impaired antioxidant KEAP1-NRF2 system in amyotrophic lateral sclerosis: NRF2 activation as a potential therapeutic strategy
  1692. Genetic or pharmacologic Nrf2 activation increases proteinuria in chronic kidney disease in mice
  1693. Microenvironmental activation of Nrf2 restricts the progression of Nrf2-activated malignant tumors
  1694. NRF2 activation and downstream effects: focus on Parkinson’s disease and brain angiotensin
  1695. NRF2 and the ambiguous consequences of its activation during initiation and the subsequent stages of tumourigenesis
  1696. Impacts of NRF2 activation in non–small‐cell lung cancer cell lines on extracellular metabolites
  1697. The Nrf2 activator RTA-408 attenuates osteoclastogenesis by inhibiting STING dependent NF-κb signaling
  1698. Electrophilic Nrf2 activators and itaconate inhibit inflammation at low dose and promote IL-1β production and inflammatory apoptosis at high dose
  1699. … mechanisms underlying hepatocellular carcinoma induction by aberrant NRF2 activation-mediated transcription networks: interaction of NRF2-KEAP1 controls the …
  1700. Dietary phenolic-type Nrf2-activators: implications in the control of toxin-induced hepatic disorders
  1701. Potential role of Nrf2 activators with dual antiviral and anti-inflammatory properties in the management of viral pneumonia
  1702. Pros and cons of NRF2 activation as adjunctive therapy in rheumatoid arthritis
  1703. Ammonium tetrathiomolybdate triggers autophagy-dependent NRF2 activation in vascular endothelial cells
  1704. Nrf2 activators as dietary phytochemicals against oxidative stress, inflammation, and mitochondrial dysfunction in autism spectrum disorders: a systematic …
  1705. Role of NRF2 and Sirtuin activators in COVID-19
  1706. EV71 virus reduces Nrf2 activation to promote production of reactive oxygen species in infected cells
  1707. Design, synthesis and identification of novel, orally bioavailable non-covalent Nrf2 activators
  1708. Nrf2 activation ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain
  1709. Bruceine D elevates Nrf2 activation to restrain Parkinson’s disease in mice through suppressing oxidative stress and inflammatory response
  1710. Systemic activation of Nrf2 pathway in Parkinson’s disease
  1711. Activation of Nrf2 by natural bioactive compounds: a promising approach for stroke?
  1712. … DBZ ameliorates neuroinflammation in LPS-stimulated microglia and ischemic stroke rats: Role of Akt (Ser473)/GSK3β (Ser9)-mediated Nrf2 activation
  1713. Nrf2 activator PB125® as a carnosic acid-based therapeutic agent against respiratory viral diseases, including COVID-19
  1714. Pharmacological activation of Nrf2 promotes wound healing
  1715. Nrf2 activation attenuates acrylamide-induced neuropathy in mice
  1716. p62 bodies: phase separation, NRF2 activation, and selective autophagic degradation
  1717. … of redox processes in biological systems with the participation of the Keap1/Nrf2/ARE signaling pathway, biogenic selenium nanoparticles as Nrf2 activators
  1718. Nrf2 activation putatively mediates clinical benefits of low-dose radiotherapy in COVID-19 pneumonia and acute respiratory distress syndrome (ARDS): Novel …
  1719. SPOP mutations promote p62/SQSTM1-dependent autophagy and Nrf2 activation in prostate cancer
  1720. Development and optimization of halogenated vinyl sulfones as Nrf2 activators for the treatment of Parkinson’s disease
  1721. Oxidative stress and redox signaling in CRPC progression: therapeutic potential of clinically-tested Nrf2-activators
  1722. Carbon monoxide releasing molecule-A1 improves nonalcoholic steatohepatitis via Nrf2 activation mediated improvement in oxidative stress and …
  1723. Ethyl carbamate triggers ferroptosis in liver through inhibiting GSH synthesis and suppressing Nrf2 activation
  1724. Metformin alleviates lead-induced mitochondrial fragmentation via AMPK/Nrf2 activation in SH-SY5Y cells
  1725. Novel biphenyl diester derivative AB-38b inhibits NLRP3 inflammasome through Nrf2 activation in diabetic nephropathy
  1726. Phloretin suppresses neuroinflammation by autophagy-mediated Nrf2 activation in macrophages
  1727. AMPK/p38/Nrf2 activation as a protective feedback to restrain oxidative stress and inflammation in microglia stimulated with sodium fluoride
  1728. Dimethyl Fumarate Triggers the Antioxidant Defense System in Human Retinal Endothelial Cells through Nrf2 Activation
  1729. Activation of the NRF2 antioxidant program sensitizes tumors to G6PD inhibition
  1730. Therapeutic effects of CO-releaser/Nrf2 activator hybrids (HYCOs) in the treatment of skin wound, psoriasis and multiple sclerosis
  1731. Eriodictyol ameliorates cognitive dysfunction in APP/PS1 mice by inhibiting ferroptosis via vitamin D receptor-mediated Nrf2 activation
  1732. Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular …
  1733. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease
  1734. Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson’s disease
  1735. NRF2 in dermatological disorders: Pharmacological activation for protection against cutaneous photodamage and photodermatosis
  1736. The genotoxic potential of mixed nitrosamines in drinking water involves oxidative stress and Nrf2 activation
  1737. Beyond direct Nrf2 activation; reinvestigating 1, 2, 4-oxadiazole scaffold as a master key unlocking the antioxidant cellular machinery for cancer therapy
  1738. β-Arrestin1 reduces oxidative stress via Nrf2 activation in the rostral ventrolateral medulla in hypertension
  1739. Non-canonical NRF2 activation promotes a pro-diabetic shift in hepatic glucose metabolism
  1740. Role of Nrf2 and its activators in cardiocerebral vascular disease
  1741. … -target directed ligands strategy for the treatment of Alzheimer’s disease: Dimethyl fumarate plus Tranilast modified Dithiocarbate as AChE inhibitor and Nrf2 activator
  1742. Physalin B ameliorates nonalcoholic steatohepatitis by stimulating autophagy and NRF2 activation mediated improvement in oxidative stress
  1743. Natural Nrf2 activators from juices, wines, coffee, and cocoa
  1744. Carveol a naturally-derived potent and emerging Nrf2 activator protects against acetaminophen-induced hepatotoxicity
  1745. Nrf2 activation is involved in osteogenic differentiation of periodontal ligament stem cells under cyclic mechanical stretch
  1746. Aerobic exercise training partially reverses the impairment of Nrf2 activation in older humans
  1747. Nrf2 activation through the PI3K/GSK-3 axis protects neuronal cells from Aβ-mediated oxidative and metabolic damage
  1748. Pharmacological activation of Nrf2 enhances functional liver regeneration
  1749. Nrf2 activation: involvement in central nervous system traumatic injuries. a promising therapeutic target of natural compounds
  1750. Activation of the Nrf2 pathway as a therapeutic strategy for ALS treatment
  1751. Discovery of eicosapentaenoic acid esters of hydroxy fatty acids as potent Nrf2 activators
  1752. Dietary prenylated flavonoid xanthohumol alleviates oxidative damage and accelerates diabetic wound healing via Nrf2 activation
  1753. Biotinylation of an acetylenic tricyclic bis (cyanoenone) lowers its potency as an NRF2 activator while creating a novel activity against BACH1
  1754. Nrf2 activation sensitizes K-Ras mutant pancreatic cancer cells to glutaminase inhibition
  1755. Proanthocyanidins-mediated Nrf2 activation ameliorates glucocorticoid-induced oxidative stress and mitochondrial dysfunction in osteoblasts
  1756. Nrf2 activation protects auditory hair cells from cisplatin-induced ototoxicity independent on mitochondrial ROS production
  1757. Mutational activation of the NRF2 pathway upregulates kynureninase resulting in tumor immunosuppression and poor outcome in lung adenocarcinoma
  1758. A small molecule NRF2 activator BC-1901S ameliorates inflammation through DCAF1/NRF2 axis
  1759. Identification and evaluation of a napyradiomycin as a potent Nrf2 activator: Anti-oxidative and anti-inflammatory activities
  1760. NRF2 activation confers resistance to eIF4A inhibitors in cancer therapy
  1761. Ferulic acid influences Nrf2 activation to restore testicular tissue from cadmium‐induced oxidative challenge, inflammation, and apoptosis in rats
  1762. Coniferaldehyde attenuates Alzheimer’s pathology via activation of Nrf2 and its targets
  1763. Harnessing the cardiovascular benefits of exercise: Are Nrf2 activators useful?
  1764. NRF2-dependent bioactivation of mitomycin C as a novel strategy to target KEAP1-NRF2 pathway activation in human cancer
  1765. Chrysin rescues rat myocardium from ischemia-reperfusion injury via PPAR-γ/Nrf2 activation
  1766. Plant-derived polyphenols as Nrf2 activators to counteract oxidative stress and intestinal toxicity induced by deoxynivalenol in swine: An emerging research …
  1767. Acute lung inflammation induced by zinc oxide nanoparticles: Evolution and intervention via NRF2 activator
  1768. Salidroside protects against osteoporosis in ovariectomized rats by inhibiting oxidative stress and promoting osteogenesis via Nrf2 activation
  1769. Flavonoids activation of the transcription factor Nrf2 as a hypothesis approach for the prevention and modulation of SARS-CoV-2 infection severity
  1770. Iron-mediated epigenetic activation of NRF2 targets
  1771. Advances of natural activators for Nrf2 signaling pathway on cholestatic liver injury protection: a review
  1772. Chlorogenic acid improves diabetic retinopathy by alleviating blood‐retinal‐barrier dysfunction via inducing Nrf2 activation
  1773. A novel uterine leiomyoma subtype exhibits NRF2 activation and mutations in genes associated with neddylation of the Cullin 3-RING E3 ligase
  1774. HACE1-mediated NRF2 activation causes enhanced malignant phenotypes and decreased radiosensitivity of glioma cells
  1775. The protective effects of flavonoids in cataract formation through the activation of Nrf2 and the inhibition of MMP-9
  1776. The novel Nrf2 activator omaveloxolone regulates microglia phenotype and ameliorates secondary brain injury after intracerebral hemorrhage in mice
  1777. The role of organosulfur compounds as Nrf2 activators and their antioxidant effects
  1778. Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents
  1779. Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease
  1780. A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model
  1781. NRF2 activation by reversible KEAP1 binding induces the antioxidant response in primary neurons and astrocytes of a Huntington’s disease mouse model
  1782. Nrf2 activation contributes to hepatic tumor-augmenting effects of developmental arsenic exposure
  1783. Activation of Nrf2 signaling pathway by natural and synthetic chalcones: A therapeutic road map for oxidative stress
  1784. Sulforaphane-mediated Nrf2 activation prevents radiation-induced skin injury through inhibiting the oxidative-stress-activated DNA damage and NLRP3 …
  1785. Nrf2 activation induces mitophagy and reverses Parkin/Pink1 knock down-mediated neuronal and muscle degeneration phenotypes
  1786. Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs
  1787. ROS-Nrf2 pathway mediates the development of TGF-β1-induced epithelial-mesenchymal transition through the activation of Notch signaling
  1788. Nrf2 Activation Attenuates Chronic Constriction Injury-Induced Neuropathic Pain via Induction of PGC-1α-Mediated Mitochondrial Biogenesis in the Spinal …
  1789. The effects of two Nrf2 activators, bardoxolone methyl and omaveloxolone, on retinal ganglion cell survival during ischemic optic neuropathy
  1790. NRF2 preserves genomic integrity by facilitating ATR activation and G2 cell cycle arrest
  1791. Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance
  1792. Antioxidative effects of chrysoeriol via activation of the Nrf2 signaling pathway and modulation of mitochondrial function
  1793. Activating Nrf2 signalling alleviates osteoarthritis development by inhibiting inflammasome activation
  1794. Dehydroepiandrosterone alleviates intestinal inflammatory damage via GPR30-mediated Nrf2 activation and NLRP3 inflammasome inhibition in colitis mice
  1795. Activation of Nrf2 to Optimise Immune Responses to Intracerebral Haemorrhage
  1796. … of Pengze crucian carp concurrent with modulating the antioxidant defense response and exerting beneficial impacts on inflammatory response via Nrf2 activation
  1797. Nrf2 Activation and NF-Kb & caspase/bax signaling inhibition by sodium butyrate alleviates LPS-induced cell injury in bovine mammary epithelial cells
  1798. Miconazole contributes to NRF2 activation by noncanonical P62-KEAP1 pathway in bladder cancer cells
  1799. Persistent activation of Nrf2 promotes a vicious cycle of oxidative stress and autophagy inhibition in cadmium-induced kidney injury
  1800. Moderate Nrf2 activation by genetic disruption of Keap1 has sex-specific effects on bone mass in mice
  1801. The novel Nrf2 activator CDDO‐EA attenuates cerebral ischemic injury by promoting microglia/macrophage polarization toward M2 phenotype in mice
  1802. Activation of Nrf2 in fibroblasts promotes a skin aging phenotype via an Nrf2-miRNA-collagen axis
  1803. Therapeutic effects of specialized pro-resolving lipids mediators on cardiac fibrosis via NRF2 activation
  1804. Activation of Nrf2 signaling: A key molecular mechanism of protection against cardiovascular diseases by natural products
  1805. Four-octyl itaconate attenuates UVB-induced melanocytes and keratinocytes apoptosis by Nrf2 activation-dependent ROS inhibition
  1806. Resveratrol mediates its anti-cancer effects by Nrf2 signaling pathway activation
  1807. Lycium barbarum polysaccharide protects rats and cardiomyocytes against ischemia/reperfusion injury via Nrf2 activation through autophagy inhibition
  1808. Urolithin A protects human dermal fibroblasts from UVA-induced photoaging through NRF2 activation and mitophagy
  1809. Effects of the phytochemical combination PB123 on Nrf2 Activation, gene expression, and the cholesterol pathway in HepG2 cells
  1810. Treatment with dimethyl fumarate reduces the formation and rupture of intracranial aneurysms: Role of Nrf2 activation
  1811. Maresin1 suppresses high-glucose-induced ferroptosis in osteoblasts via Nrf2 activation in type 2 diabetic osteoporosis
  1812. Nonalcoholic steatohepatitis and mechanisms by which it is ameliorated by activation of the CNC-bZIP transcription factor Nrf2
  1813. Dynamic modeling of Nrf2 pathway activation in liver cells after toxicant exposure
  1814. A nature-inspired Nrf2 activator protects retinal explants from oxidative stress and neurodegeneration
  1815. Itaconate prevents abdominal aortic aneurysm formation through inhibiting inflammation via activation of Nrf2
  1816. Dexmedetomidine alleviates inflammation in neuropathic pain by suppressing NLRP3 via Nrf2 activation
  1817. Dietary chlorogenic acid ameliorates oxidative stress and improves endothelial function in diabetic mice via Nrf2 activation
  1818. Allyl isothiocyanate protects acetaminophen-induced liver injury via NRF2 activation by decreasing spontaneous degradation in hepatocyte
  1819. The anti-melanogenic effects of ellagic acid through induction of autophagy in melanocytes and suppression of UVA-activated α-MSH pathways via Nrf2 activation in …
  1820. Beneficial effects of bardoxolone methyl, an Nrf2 activator, on crush-related acute kidney injury in rats
  1821. A triterpenoid Nrf2 activator, RS9, promotes LC3-associated phagocytosis of photoreceptor outer segments in a p62-independent manner
  1822. Tussilagonone ameliorates psoriatic features in keratinocytes and imiquimod-induced psoriasis-like lesions in mice via NRF2 activation
  1823. NRF2 activation ameliorates oxidative stress and improves mitochondrial function and synaptic plasticity, and in A53T α-synuclein hippocampal neurons
  1824. α-Cyperone Attenuates H2O2-Induced Oxidative Stress and Apoptosis in SH-SY5Y Cells via Activation of Nrf2
  1825. Nrf2 signaling activation by a small molecule activator compound 16 inhibits hydrogen peroxide-induced oxidative injury and death in osteoblasts
  1826. Nrf2 mediates hypoxia-inducible HIF1α activation in kidney tubular epithelial cells
  1827. Activation of Nrf2 by miR-152 inhibits doxorubicin-induced cardiotoxicity via attenuation of oxidative stress, inflammation, and apoptosis
  1828. Melatonin suppresses ferroptosis induced by high glucose via activation of the Nrf2/HO-1 signaling pathway in type 2 diabetic osteoporosis
  1829. The Nrf2 activator MIND4‐17 protects retinal ganglion cells from high glucose‐induced oxidative injury
  1830. P38 MAPK and Nrf2 activation mediated naked gold nanoparticle induced heme oxygenase-1 expression in rat aortic vascular smooth muscle cells
  1831. Luteolin Alleviates AflatoxinB1-Induced Apoptosis and Oxidative Stress in the Liver of Mice through Activation of Nrf2 Signaling Pathway
  1832. LncRNA MALAT1 facilitates inflammasome activation via epigenetic suppression of Nrf2 in Parkinson’s disease
  1833. … ameliorates experimental diabetic kidney disease by inhibiting oxidative stress via GPER mediated p62-dependent Keap1 degradation and Nrf2 activation
  1834. Cannabinoid-profiled agents improve cell survival via reduction of oxidative stress and inflammation, and Nrf2 activation in a toxic model combining hyperglycemia+ …
  1835. Neuropeptide Y Promotes Human M2 Macrophage Polarization and Enhances p62/SQSTM1-Dependent Autophagy and NRF2 Activation
  1836. Use of Physiologically Based Kinetic Modeling-Based Reverse Dosimetry to Predict In Vivo Nrf2 Activation by EGCG and Its Colonic Metabolites in Humans
  1837. Nrf2/ARE activators improve memory in aged mice via maintaining of mitochondrial quality control of brain and the modulation of gut microbiome
  1838. Gallic acid alleviates gouty arthritis by inhibiting NLRP3 inflammasome activation and pyroptosis through enhancing Nrf2 signaling
  1839. Hepatic miR-144 drives fumarase activity preventing NRF2 activation during obesity
  1840. NRF2 pathway activation by KEAP1 inhibition attenuates the manifestation of aging phenotypes in salivary glands
  1841. … overexpression alleviates hydrogen peroxide-induced apoptosis and oxidative stress in retinal ganglion cells by enhancing Nrf2 activation via Keap1 downregulation
  1842. Mechanisms underlying unidirectional laminar shear stress-mediated Nrf2 activation in endothelial cells: Amplification of low shear stress signaling by primary …
  1843. Molecular docking and dynamics guided approach to identify potential anti-inflammatory molecules as NRF2 activator to protect against drug-induced liver injury (DILI) …
  1844. Nrf2 Promotes Inflammation in Early Myocardial Ischemia-Reperfusion via Recruitment and Activation of Macrophages
  1845. Inhalable nanoparticles/microparticles of an AMPK and Nrf2 activator for targeted pulmonary drug delivery as dry powder inhalers
  1846. … metabolic syndrome and oxidative stress in high-fat diet-induced metabolic dysfunction-associated fatty liver disease (MAFLD) in rats: Role on Nrf2 activation
  1847. NRF2 pathway activation attenuates ageing-related renal phenotypes due to α-klotho deficiency
  1848. Discovery of caffeoylisocitric acid as a Keap1-dependent Nrf2 activator and its effects in mesangial cells under high glucose
  1849. Plasmodium berghei-mediated NRF2 activation in infected hepatocytes enhances parasite survival
  1850. Chemical activators of the Nrf2 signaling pathway in nonalcoholic fatty liver disease
  1851. SIRT6 inhibits cholesterol crystal-induced vascular endothelial dysfunction via Nrf2 activation
  1852. Arsenic trioxide and venetoclax synergize against AML progenitors by ROS induction and inhibition of Nrf2 activation
  1853. Resveratrol attenuates high glucose-induced osteoblast dysfunction via AKT/GSK3β/FYN-mediated NRF2 activation
  1854. Nrf2 activation protects against lithium-induced nephrogenic diabetes insipidus
  1855. Activation of NRF2 by topical apocarotenoid treatment mitigates radiation-induced dermatitis
  1856. Resveratrol inhibits MRGPRX2-mediated mast cell activation via Nrf2 pathway
  1857. Luteolin confers cerebroprotection after subarachnoid hemorrhage by suppression of NLPR3 inflammasome activation through Nrf2-dependent pathway
  1858. Anti-fibrotic activity of sitagliptin against concanavalin A-induced hepatic fibrosis. Role of Nrf2 activation/NF-κB inhibition
  1859. Generation of potent Nrf2 activators via tuning the electrophilicity and steric hindrance of vinyl sulfones for neuroprotection
  1860. Discovery of a coumarin derivative as Nrf2 activator mitigating oxidative stress and fibrosis in mesangial cells under high glucose
  1861. Resveratrol ameliorates rheumatoid arthritis via activation of SIRT1‐Nrf2 signaling pathway
  1862. Quercetin protects against lipopolysaccharide-induced intestinal oxidative stress in broiler chickens through activation of Nrf2 pathway
  1863. c-MYC-directed NRF2 drives malignant progression of head and neck cancer via glucose-6-phosphate dehydrogenase and transketolase activation
  1864. Effects of Launaea sarmentosa Extract on Lipopolysaccharide-Induced Inflammation via Suppression of NF-κB/MAPK Signaling and Nrf2 Activation
  1865. Synthesis of dithiolethiones and identification of potential neuroprotective agents via activation of Nrf2-driven antioxidant enzymes
  1866. Stabilization of Nrf2 leading to HO-1 activation protects against zinc oxide nanoparticles-induced endothelial cell death
  1867. Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties
  1868. Forsythoside a mitigates alzheimer’s-like pathology by inhibiting ferroptosis-mediated neuroinflammation via Nrf2/GPX4 axis activation
  1869. Carnosic acid protects against ferroptosis in PC12 cells exposed to erastin through activation of Nrf2 pathway
  1870. Distinct mechanisms are responsible for Nrf2-Keap1 pathway activation at different stages of rat hepatocarcinogenesis
  1871. The principal molecular mechanisms behind the activation of Keap1/Nrf2/ARE pathway leading to neuroprotective action in Parkinson’s disease
  1872. Apigenin protects human melanocytes against oxidative damage by activation of the Nrf2 pathway
  1873. Maresin1 protect against ferroptosis-induced liver injury through ROS inhibition and Nrf2/HO-1/GPX4 activation
  1874. Crosstalk between Sirtuins and Nrf2: SIRT1 activators as emerging treatment for diabetic neuropathy
  1875. Antioxidative and angiogenesis-promoting effects of tetrahedral framework nucleic acids in diabetic wound healing with activation of the Akt/Nrf2/HO-1 pathway
  1876. … use of the rosemary diterpene carnosic acid for Alzheimer’s disease, Parkinson’s disease, and long-COVID through NRF2 activation to counteract the NLRP3 …
  1877. Evaluation of oxidative damage and Nrf2 activation by combined pollution exposure in lung epithelial cells
  1878. Activation of NRF2/FPN1 pathway attenuates myocardial ischemia–reperfusion injury in diabetic rats by regulating iron homeostasis and ferroptosis
  1879. The effects of nuclear factor erythroid 2 (NFE2)-related factor 2 (Nrf2) activation in preclinical models of peripheral neuropathic pain
  1880. Activation of Nrf2/AREs-mediated antioxidant signalling, and suppression of profibrotic TGF-β1/Smad3 pathway: a promising therapeutic strategy for hepatic fibrosis …
  1881. Nrf2 promotes esophageal squamous cell carcinoma (ESCC) resistance to radiotherapy through the CaMKIIα-associated activation of autophagy
  1882. Palmatine protects against cerebral ischemia/reperfusion injury by activation of the AMPK/Nrf2 pathway
  1883. … oxidase 1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by driving EGFR endosomal trafficking and inhibiting NRF2 activation
  1884. Constitutive activation of Nrf2 in mice expands enterogenesis in small intestine through negative regulation of Math1
  1885. Tadalafil alleviates cisplatin-induced reproductive toxicity through the activation of the Nrf2/HO-1 pathway and the inhibition of oxidative stress and apoptosis in male …
  1886. Genetic alterations of Keap1 confers chemotherapeutic resistance through functional activation of Nrf2 and Notch pathway in head and neck squamous cell …
  1887. Vitamin E protects against cadmium-induced sub-chronic liver injury associated with the inhibition of oxidative stress and activation of Nrf2 pathway
  1888. Nrf2 activation mediates antiallodynic effect of electroacupuncture on a rat model of complex regional pain syndrome type-I through reducing local oxidative …
  1889. Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress
  1890. Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer
  1891. Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T …
  1892. Nrf2 activation in the human brain after stroke due to supratentorial intracerebral haemorrhage: a case–control study
  1893. Loss-of-function mutations in KEAP1 drive lung cancer progression via KEAP1/NRF2 pathway activation
  1894. Diethylnitrosamine and thioacetamide-induced hepatic damage and early carcinogenesis in rats: Role of Nrf2 activator dimethyl fumarate and NLRP3 inhibitor …
  1895. Activation of Nrf2 signaling protects hypoxia‐induced HTR‐8/SVneo cells against ferroptosis
  1896. NRF2 Exerts Anti-Inflammatory Effects in LPS-Induced gEECs by Inhibiting the Activation of the NF-κB
  1897. Nrf2 mutation/activation is dispensable for the development of chemically induced mouse HCC
  1898. Irisin protects against sepsis-associated encephalopathy by suppressing ferroptosis via activation of the Nrf2/GPX4 signal axis
  1899. The effect of dietary phytochemicals on nuclear factor erythroid 2-related factor 2 (Nrf2) activation: A systematic review of human intervention trials
  1900. Nrf2 activation by Morinda citrifolia L.(Noni) fruit juices
  1901. Paeonol protects melanocytes against hydrogen peroxide‐induced oxidative stress through activation of Nrf2 signaling pathway
  1902. Transcriptional activation of antioxidant gene expression by Nrf2 protects against mitochondrial dysfunction and neuronal death associated with acute and chronic …
  1903. Fisetin attenuates doxorubicin-induced cardiomyopathy in vivo and in vitro by inhibiting ferroptosis through SIRT1/Nrf2 signaling pathway activation
  1904. Activation of p62-Keap1-Nrf2 pathway protects 6-hydroxydopamine-induced ferroptosis in dopaminergic cells
  1905. Phyllostachys nigra Variety Henosis, a Domestic Bamboo Species, Protects PC12 Cells from Oxidative Stress-mediated Cell Injury through Nrf2 Activation
  1906. β-Caryophyllene suppresses ferroptosis induced by cerebral ischemia reperfusion via activation of the NRF2/HO-1 signaling pathway in MCAO/R rats
  1907. Activation of the NRF2 pathway in Keap1-knockdown mice attenuates progression of age-related hearing loss
  1908. Rosmarinic acid exerts anti-inflammatory effect and relieves oxidative stress via Nrf2 activation in carbon tetrachloride-induced liver damage
  1909. Puerarin induces Nrf2 as a cytoprotective mechanism to prevent cadmium-induced autophagy inhibition and NLRP3 inflammasome activation in AML12 hepatic cells
  1910. Pinocembrin ameliorates post-infarct heart failure through activation of Nrf2/HO-1 signaling pathway
  1911. Age-related mitochondrial impairment and renal injury is ameliorated by sulforaphane via activation of transcription factor NRF2
  1912. NRF2 activation protects against valproic acid-induced disruption of neurogenesis in P19ácells
  1913. The ameliorative effect of kaempferol against CdCl2- mediated renal damage entails activation of Nrf2 and inhibition of NF-kB
  1914. … chronic unpredictable mild stress-induced depressive-like behaviors via restoring changes in oxidative stress and the activation of Nrf2 signaling pathway in …
  1915. TDAG51-Deficiency Podocytes are Protected from High-Glucose-Induced Damage Through Nrf2 Activation via the AKT–GSK-3β Pathway
  1916. Cyanidin chloride induces apoptosis by inhibiting NF-κB signaling through activation of Nrf2 in colorectal cancer cells
  1917. Ferulic Acid Ameliorates MPP+/MPTP-Induced Oxidative Stress via ERK1/2-Dependent Nrf2 Activation: Translational Implications for Parkinson Disease Treatment
  1918. Nrf2 activation is involved in cyclic mechanical stress-stimulated osteogenic differentiation in periodontal ligament stem cells via pi3k/akt signaling and ho1 …
  1919. Ginsenoside Rg1 reduces oxidative stress via Nrf2 activation to regulate age-related mesenchymal stem cells fate switch between osteoblasts and adipocytes
  1920. Melatonin Prevents Cartilage Degradation in Early‐Stage Osteoarthritis Through Activation of miR‐146a/NRF2/HO‐1 Axis
  1921. TRPV1 Modulator Ameliorates Alzheimer-Like Amyloid-β Neuropathology via Akt/Gsk3β-Mediated Nrf2 Activation in the Neuro-2a/APP Cell Model
  1922. Lipoxin A4 attenuates MSU-crystal-induced NLRP3 inflammasome activation through suppressing Nrf2 thereby increasing TXNRD2
  1923. Honokiol alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo
  1924. Amentoflavone ameliorates carrageenan-induced pleurisy and lung injury by inhibiting the NF-κB/STAT3 pathways via Nrf2 activation
  1925. Activation of Nrf2 in astrocytes suppressed PD-like phenotypes via antioxidant and autophagy pathways in rat and Drosophila models
  1926. Activation of the Nrf2/HO-1 signaling pathway by dimethyl fumarate ameliorates complete Freund’s adjuvant-induced arthritis in rats
  1927. Britanin relieves ferroptosis-mediated myocardial ischaemia/reperfusion damage by upregulating GPX4 through activation of AMPK/GSK3β/Nrf2 signalling
  1928. Sinomenine activation of Nrf2 signaling prevents inflammation and cerebral injury in a mouse model of ischemic stroke
  1929. Nrf2/HO-1 signaling activator acetyl-11-keto-beta Boswellic acid (AKBA)-Mediated Neuroprotection in Methyl Mercury-induced experimental model of ALS
  1930. The anti-arthritis effect of sulforaphane, an activator of Nrf2, is associated with inhibition of both B cell differentiation and the production of inflammatory …
  1931. … suppresses inflammation, apoptosis and oxidative stress in cigarette smoke-induced human bronchial epithelial cells through activation of Nrf2/HO-1 and …
  1932. Upregulation of antioxidant and autophagy pathways via NRF2 activation protects spinal cord neurons from ozone damage
  1933. Immune-responsive gene 1 protects against liver injury caused by concanavalin A via the activation Nrf2/HO-1 pathway and inhibition of ROS activation pathways
  1934. NRF2 activation inhibits valproic acid-induced neural tube defects in mice
  1935. Ferritinophagy-mediated ferroptosis and activation of Keap1/Nrf2/HO-1 pathway were conducive to EMT inhibition of gastric cancer cells in action of 2, 2-di …
  1936. Identification and optimization of piperlongumine analogues as potential antioxidant and anti-inflammatory agents via activation of Nrf2
  1937. NRF2 activation induced by PML‐RARα promotes microRNA 125b‐1 expression and confers resistance to chemotherapy in acute promyelocytic leukemia
  1938. Sodium‐glucose cotransporter‐2 inhibition reduces cellular senescence in the diabetic kidney by promoting ketone body‐induced NRF2 activation
  1939. The protective role of Zingerone in a murine asthma model via activation of the AMPK/Nrf2/HO-1 pathway
  1940. Danshensu attenuates cisplatin-induced nephrotoxicity through activation of Nrf2 pathway and inhibition of NF-κB
  1941. Metformin promotes osteogenic differentiation and protects against oxidative stress-induced damage in periodontal ligament stem cells via activation of the Akt/Nrf2 …
  1942. Emodin protects against acute pancreatitis-associated lung injury by inhibiting NLPR3 inflammasome activation via Nrf2/HO-1 signaling
  1943. Phillyrin mitigates apoptosis and oxidative stress in hydrogen peroxide-treated RPE cells through activation of the Nrf2 signaling pathway
  1944. Urolithin A protects against acetaminophen-induced liver injury in mice via sustained activation of Nrf2
  1945. Sirt6-mediated Nrf2/HO-1 activation alleviates angiotensin II-induced DNA DSBs and apoptosis in podocytes
  1946. Tanshinone IIA prevents rifampicin‐induced liver injury by regulating BSEP/NTCP expression via epigenetic activation of NRF2
  1947. Zhen-Wu decoction and lactiflorin, an ingredient predicted by in silico modelling, alleviate uremia induced cardiac endothelial injury via Nrf2 activation
  1948. Antioxidation and Nrf2-mediated heme oxygenase-1 activation contribute to renal protective effects of hydralazine in diabetic nephropathy
  1949. Sulforaphane prevents angiotensin II‐induced cardiomyopathy by activation of Nrf2 through epigenetic modification
  1950. Activation of NRF2 by APE1/REF1 is redox-dependent in Barrett’s related esophageal adenocarcinoma cells
  1951. Sulforaphane induces colorectal cancer cell proliferation through Nrf2 activation in a p53-dependent manner
  1952. Garcinia cambogia Ameliorates Non-Alcoholic Fatty Liver Disease by Inhibiting Oxidative Stress-Mediated Steatosis and Apoptosis through NRF2-ARE Activation
  1953. Sulforaphane inhibits NLRP3 inflammasome activation in microglia through Nrf2-mediated miRNA alteration
  1954. … shows psycho-cardiology therapeutic effect on acute myocardial infarction with comorbid anxiety by the activation of Nrf2/HO-1 pathway and suppression of …
  1955. Dehydroepiandrosterone attenuates LPS-induced inflammatory responses via activation of Nrf2 in RAW264. 7 macrophages
  1956. Photodriven nanoreactor with a hydrogen-insulin double act repairs diabetic wounds through Nrf2 pathway activation
  1957. Effects of inorganic arsenic on human prostate stem-progenitor cell transformation, autophagic flux blockade, and NRF2 pathway activation
  1958. The protective effect of sulforaphane against oxidative stress through activation of NRF2/ARE pathway in human granulosa cells
  1959. Alpinetin inhibits macrophage infiltration and atherosclerosis by improving the thiol redox state: Requirement of GSk3β/Fyn‐dependent Nrf2 activation
  1960. Sestrin1 exerts a cytoprotective role against oxygen-glucose deprivation/reoxygenation-induced neuronal injury by potentiating Nrf2 activation via the modulation of …
  1961. Chalcone-derived Nrf2 activator protects cognitive function via maintaining neuronal redox status
  1962. Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway
  1963. Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling
  1964. FAM129B‐dependent activation of NRF2 promotes an invasive phenotype in BRAF mutant melanoma cells
  1965. Sulforaphane attenuates hexavalent chromium-induced cardiotoxicity via the activation of the Sesn2/AMPK/Nrf2 signaling pathway
  1966. Anti-inflammatory Role of Trilobatin on Lipopolysaccharide-induced Acute Lung Injury through Activation of AMPK/GSK3β-Nrf2 Pathway.
  1967. Pharmacological activation of Nrf2 by rosolic acid attenuates endoplasmic reticulum stress in endothelial cells
  1968. Bisdemethoxycurcumin Attenuated Renal Injury via Activation of Keap1/Nrf2 Pathway in High-Fat Diet-Fed Mice
  1969. Role of Nrf2 Pathway Activation in Neurological Disorder: A Brief Review
  1970. Nrf2 activation for kidney disease treatment—a mixed blessing?
  1971. A comparison study between dimethyl itaconate and dimethyl fumarate in electrophilicity, Nrf2 activation, and anti-inflammation in vitro
  1972. Taraxasterol protects hippocampal neurons from oxygen-glucose deprivation-induced injury through activation of Nrf2 signalling pathway
  1973. Protective effects of Nrf2–ARE activator on dopaminergic neuronal loss in Parkinson disease model mice: Possible involvement of heme oxygenase-1
  1974. Recombinant CCL17 enhances hematoma resolution and activation of CCR4/ERK/Nrf2/CD163 signaling pathway after intracerebral hemorrhage in mice
  1975. … effects of nanoparticle-selenium, selenium-enriched yeast and sodium selenite against cadmium-induced cardiotoxicity via AHR/CAR/PXR/Nrf2 pathways activation
  1976. Anti-inflammatory activity of the extracts from Rodgersia podophylla leaves through activation of Nrf2/HO-1 pathway, and inhibition of NF-κB and MAPKs pathway in …
  1977. Resveratrol protects against CIH-induced myocardial injury by targeting Nrf2 and blocking NLRP3 inflammasome activation
  1978. Formononetin protects against cisplatin‑induced acute kidney injury through activation of the PPARα/Nrf2/HO‑1/NQO1 pathway
  1979. Ellagic acid protects dopamine neurons from rotenone‐induced neurotoxicity via activation of Nrf2 signalling
  1980. PPARγ activation mitigates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of Nrf2/HO-1 signaling pathway
  1981. Downregulation of FOXO6 alleviates hypoxia-induced apoptosis and oxidative stress in cardiomyocytes by enhancing Nrf2 activation via upregulation of SIRT6
  1982. Activation of Nrf2 signaling by oltipraz inhibits death of human macrophages with mycobacterium tuberculosis infection
  1983. Erythronium japonicum Alleviates Inflammatory Pain by Inhibiting MAPK Activation and by Suppressing NF-κB Activation via ERK/Nrf2/HO-1 Signaling Pathway
  1984. … cell apoptosis and mitochondrial dysfunction in remote lung tissue after renal ischemia and reperfusion via Nrf2 activation-mediated NLRP3 pathway …
  1985. GYY4137 protected the integrity of the blood‐brain barrier via activation of the Nrf2/ARE pathway in mice with sepsis
  1986. Pharmaceutical activation of Nrf2 accelerates diabetic wound healing by exosomes from bone marrow mesenchymal stem cells
  1987. Hemistepsin A protects human keratinocytes against hydrogen peroxide-induced oxidative stress through activation of the Nrf2/HO-1 signaling pathway
  1988. Anti-neuropathic pain activity of Ajugarin-I via activation of Nrf2 signaling and inhibition of TRPV1/TRPM8 nociceptors in STZ-induced diabetic neuropathy
  1989. The activation of nuclear factor-E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling blunts cholestasis-induced liver and kidney injury
  1990. Procyanidins inhibit fine particulate matter-induced vascular smooth muscle cells apoptosis via the activation of the Nrf2 signaling pathway
  1991. Doxorubicin cardiomyopathy is ameliorated by acacetin via Sirt1‐mediated activation of AMPK/Nrf2 signal molecules
  1992. Alginate oligosaccharide ameliorates D-galactose-induced kidney aging in mice through activation of the Nrf2 signaling pathway
  1993. … enhances therapeutic effect of human umbilical cord mesenchymal stem cells against LPS-mediated inflammation and lung injury via activation of Nrf2/HO-1 signaling
  1994. Melatonin suppresses ferroptosis via activation of the Nrf2/HO-1 signaling pathway in the mouse model of sepsis-induced acute kidney injury
  1995. Arctiin antagonizes triptolide-induced hepatotoxicity via activation of Nrf2 pathway
  1996. Asparaginyl endopeptidase (AEP) regulates myocardial apoptosis in response to radiation exposure via alterations in NRF2 activation
  1997. Mitigation of Aflatoxin B1 Hepatoxicity by Dietary Hedyotis diffusa Is Associated with Activation of NRF2/ARE Signaling in Chicks
  1998. Resveratrol and FGF1 synergistically ameliorates doxorubicin-induced cardiotoxicity via activation of SIRT1-NRF2 pathway
  1999. Enhanced autophagy and NFE2L2/NRF2 pathway activation in SPOP mutation-driven prostate cancer
  2000. Dimethyl fumarate and curcumin attenuate hepatic ischemia/reperfusion injury via Nrf2/HO-1 activation and anti-inflammatory properties
  2001. Activation of Nrf2 by electrophiles is largely independent of the selenium status of HepG2 cells
  2002. Nrf2 Activation Protects Against Organic Dust and Hydrogen Sulfide Exposure Induced Epithelial Barrier Loss and K. pneumoniae Invasion
  2003. Asiatic acid alleviates LPS-induced acute kidney injury in broilers by inhibiting oxidative stress and ferroptosis via activation of the Nrf2 pathway
  2004. Mechanism of Cadmium Exposure Induced Hepatotoxicity in the Mud Crab (Scylla paramamosain): Activation of Oxidative Stress and Nrf2 Signaling Pathway
  2005. Involvement of estrogen receptor-α in the activation of Nrf2-antioxidative signaling pathways by silibinin in pancreatic β-cells
  2006. TRIM22 inhibits osteosarcoma progression through destabilizing NRF2 and thus activation of ROS/AMPK/mTOR/autophagy signaling
  2007. Luteolin prevents THP-1 macrophage pyroptosis by suppressing ROS production via Nrf2 activation
  2008. 6′-O-galloylpaeoniflorin alleviates inflammation and oxidative stress in pediatric pneumonia through activating Nrf2 activation
  2009. Sulforaphane inhibits the production of Aβ partially through the activation of Nrf2-regulated oxidative stress
  2010. … saponin ameliorates myocardial infarction-induced cardiac fibrosis by targeting Keap1/Nrf2 to regulate oxidative stress and inhibit cardiac-fibroblast activation and …
  2011. Phosphodiesterase 4B is required for NLRP3 inflammasome activation by positive feedback with Nrf2 in the early phase of LPS-induced acute lung injury
  2012. Discovery of 4-anilinoquinolinylchalcone derivatives as potential NRF2 activators
  2013. … of DiDang Tang Against AlCl3-Induced Oxidative Stress and Apoptosis in PC12 Cells Through the Activation of SIRT1-Mediated Akt/Nrf2/HO-1 Pathway
  2014. p62-induced cancer-associated fibroblast activation via the Nrf2-ATF6 pathway promotes lung tumorigenesis
  2015. … PC12 cells from corticosterone-induced neurotoxicity via regulation of metabolic disorders, attenuation ERK1/2-NF-κB pathway, activation Nrf2-Keap1 pathway, and …
  2016. Activation of autophagy and suppression of apoptosis by dapagliflozin attenuates experimental inflammatory bowel disease in rats: Targeting AMPK/mTOR, HMGB1 …
  2017. Lutein reverses hyperglycemia-mediated blockage of Nrf2 translocation by modulating the activation of intracellular protein kinases in retinal pigment epithelial (ARPE …
  2018. … attenuates secondary brain injury following intracerebral hemorrhage by inhibiting NLRP3 inflammasome activation and promoting Nrf2/ARE signaling pathway in …
  2019. … Keap1-Nrf2/Trx-1 axis by daphnetin protects against oxidative stress-driven hepatotoxicity via inhibiting ASK1/JNK and Txnip/NLRP3 inflammasome activation
  2020. The neuroprotective effect of phillyrin in intracerebral hemorrhagic mice is produced by activation of the Nrf2 signaling pathway
  2021. Specialized Proresolving Mediators Protect Against Experimental Autoimmune Myocarditis by Modulating Ca2+ Handling and NRF2 Activation
  2022. Arenaria kansuensis attenuates pulmonary fibrosis in mice via the activation of Nrf2 pathway and the inhibition of NF‐kB/TGF‐beta1/Smad2/3 pathway
  2023. Activation of anti-oxidant Keap1/Nrf2 pathway modulates efficacy of dihydroartemisinin-based monotherapy and combinatory therapy with ionizing radiation
  2024. Bdh1 overexpression ameliorates hepatic injury by activation of Nrf2 in a MAFLD mouse model
  2025. Lipid accumulation-induced hepatocyte senescence regulates the activation of hepatic stellate cells through the Nrf2-antioxidant response element pathway
  2026. Esculetin alleviates murine lupus nephritis by inhibiting complement activation and enhancing Nrf2 signaling pathway
  2027. Sporadic activation of an oxidative stress–dependent NRF2-p53 signaling network in breast epithelial spheroids and premalignancies
  2028. Irg1-itaconate axis protects against acute kidney injury via activation of Nrf2
  2029. Icariin protects podocytes from NLRP3 activation by Sesn2-induced mitophagy through the Keap1-Nrf2/HO-1 axis in diabetic nephropathy
  2030. The aggravation of allergic airway inflammation with dibutyl phthalate involved in Nrf2-mediated activation of the mast cells
  2031. IL-4 induces reparative phenotype of RPE cells and protects against retinal neurodegeneration via Nrf2 activation
  2032. Spinal Nrf2 translocation may inhibit neuronal NF‐κB activation and alleviate allodynia in a rat model of bone cancer pain
  2033. Combined lead and zinc oxide‐nanoparticles induced thyroid toxicity through 8‐OHdG oxidative stress‐mediated inflammation, apoptosis, and Nrf2 activation in rats
  2034. … the main antioxidant in coffee, reduces radiation-induced apoptosis and DNA damage via NF-E2-related factor 2 (Nrf2) activation in hepatocellular carcinoma
  2035. Hydrogen sulfide attenuates renal I/R‑induced activation of the inflammatory response and apoptosis via regulating Nrf2‑mediated NLRP3 signaling pathway …
  2036. Activation of p62-NRF2 Axis protects against doxorubicin-induced ferroptosis in cardiomyocytes: a novel role and molecular mechanism of resveratrol
  2037. Sulforaphane suppresses carcinogenesis of colorectal cancer through the ERK/Nrf2‑UDP glucuronosyltransferase 1A metabolic axis activation
  2038. Cardioprotective effects of melatonin against myocardial ischaemia/reperfusion injury: Activation of AMPK/Nrf2 pathway
  2039. Diosmetin alleviates cerebral ischemia‐reperfusion injury through Keap1‐mediated Nrf2/ARE signaling pathway activation and NLRP3 inflammasome inhibition
  2040. Adenylosuccinate lyase is oncogenic in colorectal cancer by causing mitochondrial dysfunction and independent activation of NRF2 and mTOR-MYC-axis
  2041. Discovery of polypodiside as a Keap1-dependent Nrf2 activator attenuating oxidative stress and accumulation of extracellular matrix in glomerular mesangial cells …
  2042. Nrf2 activation with CDDO-Methyl promotes beneficial and deleterious clinical effects in transgenic mice with sickle cell anemia
  2043. … extraction, characterization of a polysaccharide from Salvia miltiorrhiza Bunge and its antioxidant effects via ferroptosis-mediated activation of the Nrf2/HO-1 pathway
  2044. Suppression of Fpr2 expression protects against endotoxin-induced acute lung injury by interacting with Nrf2-regulated TAK1 activation
  2045. Baicalein alleviates liver oxidative stress and apoptosis induced by high-level glucose through the activation of the PERK/Nrf2 signaling pathway
  2046. Butein ameliorates oxidative stress in H9c2 cardiomyoblasts through activation of the NRF2 signaling pathway
  2047. … exposure triggers testicular dysfunction and oxidative stress in mice via p38/ERK MAPK inhibition and Nrf2-mediated antioxidant defense activation
  2048. VDR activation attenuates osteoblastic ferroptosis and senescence by stimulating the Nrf2/GPX4 pathway in age-related osteoporosis
  2049. 7-hydroxycoumarin attenuates colistin-induced kidney injury in mice through the decreased level of histone deacetylase 1 and the activation of Nrf2 signaling …
  2050. Newly synthesized chitosan-nanoparticles attenuate carbendazim hepatorenal toxicity in rats via activation of Nrf2/HO1 signalling pathway
  2051. … microvascular endothelial cell permeability and apoptosis by reducing oxidative stress and inflammation associated with activation of Nrf2 signaling in oxygen …
  2052. The activation of AMPK/NRF2 pathway in lung epithelial cells is involved in the protective effects of kinsenoside on lipopolysaccharide-induced acute lung …
  2053. … protects retinal pigment epithelial cells against hydrogen peroxide-induced oxidative stress and apoptosis through the activation of Nrf2/HO-1 pathway
  2054. … Synthesis of Novel Multitarget-Directed Ligands with Ca2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation
  2055. docosahexaenoic acid esters of hydroxy fatty acid is a novel activator of NRF2
  2056. The effect of Nrf2 activators tBHQ and 4-octyl itaconate on the nucleus pulposus cell degeneration.
  2057. Inhibiting BTB domain and CNC homolog 1 (Bach1) as an alternative to increase Nrf2 activation in chronic diseases
  2058. Friend or foe: xenobiotic activation of Nrf2 in disease control and cardioprotection
  2059. Co-activation of Akt, Nrf2, and NF-κB signals under UPRER in torpid Myotis ricketti bats for survival
  2060. Choline protects the heart from doxorubicin-induced cardiotoxicity through vagal activation and Nrf2/HO-1 pathway
  2061. Dietary olive oil intake aggravates psoriatic skin inflammation in mice via Nrf2 activation and polyunsaturated fatty acid imbalance
  2062. Lycopene prevents carcinogen-induced cutaneous tumor by enhancing activation of the Nrf2 pathway through p62-triggered autophagic Keap1 degradation
  2063. … of amygdalin against angiotensin II induced cardiac hypertrophy, oxidative stress and inflammatory responses through modulation of Nrf2 and NF‐κB activation
  2064. Heme-mediated activation of the Nrf2/HO-1 axis attenuates calcification of valve interstitial cells
  2065. … protected against diabetic cardiomyopathy through inducing autophagy and reducing apoptosis relying on Nrf2 upregulation and transcription activation
  2066. Lycopene inhibits IL-6 expression by upregulating NQO1 and HO-1 via activation of Nrf2 in ethanol/lipopolysaccharide-stimulated pancreatic acinar cells
  2067. Leonurine inhibits the TXNIP/NLRP3 and NF‐κB pathways via Nrf2 activation to alleviate carrageenan‐induced pleurisy in mice
  2068. Extracellular superoxide dismutase prevents skin aging by promoting collagen production through the activation of AMPK and Nrf2/HO-1 cascades
  2069. … , ameliorates acute pancreatitis-associated liver injury partially through Nrf2-mediated antioxidant effects and inhibition of NLRP3 inflammasome activation
  2070. … on arsenic trioxide-induced hepatic injury: involvement of suppression in oxidative stress and inflammation through activation of Nrf2 signaling pathway in …
  2071. Sargachromenol Purified from Sargassum horneri Inhibits Inflammatory Responses via Activation of Nrf2/HO-1 Signaling in LPS-Stimulated Macrophages
  2072. Ergosterol limits osteoarthritis development and progression through activation of Nrf2 signaling
  2073. Chlamydia trachomatis Pgp3 protein regulates oxidative stress via activation of the Nrf2/NQO1 signal pathway
  2074. Allicin mitigates hepatic injury following cyclophosphamide administration via activation of Nrf2/ARE pathways and through inhibition of inflammatory and apoptotic …
  2075. … oxidized low‑density lipoprotein‑induced HUVEC injury by inhibiting NLRP3 inflammasome‑mediated pyroptosis via the activation of the SIRT1/Nrf2 signaling …
  2076. Vincamine protects against cisplatin induced nephrotoxicity via activation of Nrf2/HO-1 and hindering TLR4/IFN-γ/CD44 cells inflammatory cascade
  2077. Nrf2 regulates granuloma formation and macrophage activation during mycobacterium avium infection via mediating nramp1 and ho-1 expressions
  2078. Loganin inhibits lipopolysaccharide-induced inflammation and oxidative response through the activation of the Nrf2/HO-1 signaling pathway in RAW264. 7 …
  2079. Artemisinin analogue SM934 protects against lupus-associated antiphospholipid syndrome via activation of Nrf2 and its targets
  2080. DPHC from Alpinia officinarum ameliorates oxidative stress and insulin resistance via activation of Nrf2/ARE pathway in db/db mice and high glucose-treated …
  2081. 5-Caffeoylquinic acid ameliorates oxidative stress-mediated cell death via Nrf2 activation in hepatocytes
  2082. Anti-Inflammatory and Anti-Oxidative Effects of luteolin-7-O-glucuronide in LPS-Stimulated Murine Macrophages through TAK1 Inhibition and Nrf2 Activation
  2083. The activation of Nrf2/HO-1 by 8-Epi-7-deoxyloganic acid attenuates inflammatory symptoms through the suppression of the MAPK/NF-κB signaling cascade in in vitro …
  2084. Ergothioneine alleviates senescence of fibroblasts induced by UVB damage of keratinocytes via activation of the Nrf2/HO-1 pathway and HSP70 in keratinocytes
  2085. Andrographolide Attenuates Blood–Brain Barrier Disruption, Neuronal Apoptosis, and Oxidative Stress Through Activation of Nrf2/HO-1 Signaling Pathway in …
  2086. Solving the problem of assessing synergy and antagonism for non-traditional dosing curve compounds using the DE/ZI method: application to Nrf2 activators
  2087. NOX4 blockade suppresses titanium nanoparticle-induced bone destruction via activation of the Nrf2 signaling pathway
  2088. Activation of Nrf2 modulates protective immunity against Mycobacterium tuberculosis infection in THP1-derived macrophages
  2089. The alleviative effect of flavonol‐type Nrf2 activator rhamnazin from Physalis alkekengi L. var. franchetii (Mast.) Makino on pulmonary disorders
  2090. Korean Red Ginseng Extract Inhibits IL-8 Expression via Nrf2 Activation in Helicobacter pylori-Infected Gastric Epithelial Cells
  2091. Procyanidins inhibit zearalenone-induced apoptosis and oxidative stress of porcine testis cells through activation of Nrf2 signaling pathway
  2092. Pratensein mitigates oxidative stress and NLRP3 inflammasome activation in OGD/R-injured HT22 cells by activating Nrf2-anti-oxidant signaling
  2093. BRG1 protects the heart from acute myocardial infarction by reducing oxidative damage through the activation of the NRF2/HO1 signaling pathway
  2094. An Update on the Role of Nrf2 and its Activators in Diseases Associated with Oxidative Stress.
  2095. Cadmium exposure induces rat proximal tubular cells injury via p62-dependent Nrf2 nucleus translocation mediated activation of AMPK/AKT/mTOR pathway
  2096. Jujube (Ziziphus jujuba Mill.) Protects Hepatocytes against Alcohol-Induced Damage through Nrf2 Activation
  2097. … effect of danshen Zexie decoction against non-alcoholic fatty liver disease through inhibition of ROS/NLRP3/IL-1β pathway by Nrf2 signaling activation
  2098. Folic acid protects melanocytes from oxidative stress via activation of Nrf2 and inhibition of HMGB1
  2099. Selenium-rich yeast attenuates ochratoxin A-induced small intestinal injury in broiler chickens by activating the Nrf2 pathway and inhibiting NF-KB activation
  2100. Activation of MT1/MT2 to protect testes and leydig cells against cisplatin-induced oxidative stress through the SIRT1/Nrf2 signaling pathway
  2101. Activation of Nrf2 pathway by dimethyl fumarate attenuates renal ischemia-reperfusion injury
  2102. Tianxiangdan improves coronary microvascular dysfunction in rats by inhibiting microvascular inflammation via Nrf2 activation
  2103. Exercise protects against ethanol-induced damage in rat heart and liver through the inhibition of apoptosis and activation of Nrf2/Keap-1/HO-1 pathway
  2104. Nanocurcumin alleviates inflammation and oxidative stress in LPS-induced mastitis via activation of Nrf2 and suppressing TLR4-mediated NF-κB and HMGB1 …
  2105. Nattokinase attenuates bisphenol A or gamma irradiation-mediated hepatic and neural toxicity by activation of Nrf2 and suppression of inflammatory …
  2106. Autophagy assuages myocardial infarction through Nrf2 signaling activation-mediated reactive oxygen species clear.
  2107. Protective effects of rare earth lanthanum on acute ethanol-induced oxidative stress in mice via Keap 1/Nrf2/p62 activation
  2108. Sitagliptin Alleviates Radiation-Induced Intestinal Injury by Activating NRF2-Antioxidant Axis, Mitigating NLRP3 Inf–lammasome Activation, and Reversing Gut …
  2109. Asiaticoside ameliorates osteoarthritis progression through activation of Nrf2/HO-1 and inhibition of the NF-κB pathway
  2110. NRF2 activator A-1396076 ameliorates inflammation in autoimmune disease models by inhibiting antigen dependent T cell activation
  2111. DL0410 attenuates oxidative stress and neuroinflammation via BDNF/TrkB/ERK/CREB and Nrf2/HO-1 activation
  2112. Function‐Oriented and Modular (+/−)‐cis‐Pseudoguaianolide Synthesis: Discovery of New Nrf2 Activators and NF‐κB Inhibitors
  2113. Suppression of LPS-induced inflammation by chalcone flavokawain a through activation of Nrf2/ARE-mediated antioxidant genes and inhibition of ROS/NFκB …
  2114. Galangin ameliorates Imiquimod-Induced psoriasis-like skin inflammation in BALB/c mice via down regulating NF-κB and activation of Nrf2 signaling pathways
  2115. Urolithin A ameliorates diabetic retinopathy via activation of the Nrf2/HO-1 pathway
  2116. Chrysin attenuates high glucose-induced BMSC dysfunction via the activation of the PI3K/AKT/Nrf2 signaling pathway
  2117. … oxalate-induced epithelial-mesenchymal transition of renal tubular cells by its anti-oxidative property through activation of Nrf2 signaling and suppression of …
  2118. … from bone marrow mesenchymal stem cells pretreated with berberine rescues neurons with oxidative damage through activation of the Keap1-Nrf2-HO-1 signaling …
  2119. The skin-whitening effects of ectoine via the suppression of α-MSH-stimulated melanogenesis and the activation of antioxidant Nrf2 pathways in UVA-irradiated …
  2120. Activation of autophagy by sitagliptin attenuates cadmium-induced testicular impairment in rats: Targeting AMPK/mTOR and Nrf2/HO-1 pathways
  2121. Protective effects of 1, 25 dihydroxyvitamin D3 against high-glucose-induced damage in human umbilical vein endothelial cells involve activation of Nrf2 antioxidant …
  2122. A hydrogen peroxide responsive prodrug of Keap1-Nrf2 inhibitor for improving oral absorption and selective activation in inflammatory conditions
  2123. Involvement of Nrf2 and Keap1 in the activation of antioxidant responsive element (ARE) by chemopreventive agent peptides from soft-shelled turtle
  2124. Melatonin suppresses Ti-particle-induced inflammatory osteolysis via activation of the Nrf2/Catalase signaling pathway
  2125. MiR-30a-3p ameliorates oxidative stress in rheumatoid arthritis synovial fibroblasts via activation of Nrf2-ARE signaling pathway
  2126. EGF released from human placental mesenchymal stem cells improves premature ovarian insufficiency via NRF2/HO-1 activation
  2127. … AML-12 hepatocyte EMT and LX-2 HSC activation and alleviates mouse liver fibrosis provoked by CCl 4: roles in the activation of the Nrf2 cascade and subsequent …
  2128. Nrf2 activation mediates the protection of mouse Sertoli Cells damage under acute heat stress conditions
  2129. Hesperidin ameliorates hypobaric hypoxia-induced retinal impairment through activation of Nrf2/HO-1 pathway and inhibition of apoptosis
  2130. The combination of NRF1 and Nrf2 activators in myoblasts stimulate mechanisms of proteostasis without changes in mitochondrial respiration
  2131. Gastrodin pretreatment protects liver against ischemia-reperfusion injury via activation of the Nrf2/HO-1 pathway
  2132. … effect of astaxanthin on blue light light-emitting diode-induced retinal cell damage via free radical scavenging and activation of PI3K/Akt/Nrf2 pathway in 661W cell …
  2133. Melatonin inhibits the apoptosis of rooster Leydig cells by suppressing oxidative stress via AKT-Nrf2 pathway activation
  2134. Lycopene mitigates arsenic-induced nephrotoxicity with activation of the Nrf2 pathway in mice
  2135. Sodium tanshinone IIA sulfonate attenuates silica-induced pulmonary fibrosis in rats via activation of the Nrf2 and thioredoxin system
  2136. Polysaccharides from Enteromorpha prolifera protect against carbon tetrachloride-induced acute liver injury in mice via activation of Nrf2/HO-1 signaling, and …
  2137. Astaxanthin protects human granulosa cells against oxidative stress through activation of NRF2/ARE pathway and its downstream phase II enzymes
  2138. Activation of the Nrf2/HO-1 pathway by curcumin inhibits oxidative stress in human nasal fibroblasts exposed to urban particulate matter
  2139. Rg1 protects H9C2 cells from high glucose‐/palmitate‐induced injury via activation of AKT/GSK‐3β/Nrf2 pathway
  2140. … lysosomal membrane permeabilization and leads to ferroptosis insensitivity via the autophagy dysfunction/p62-KEAP1-NRF2 activation in neuronal cells
  2141. Berbamine induced AMPK activation regulates mTOR/SREBP-1c axis and Nrf2/ARE pathway to allay lipid accumulation and oxidative stress in steatotic HepG2 cells
  2142. Modified Qing’e Formula protects against UV-induced skin oxidative damage via the activation of Nrf2/ARE defensive pathway
  2143. Activation of AMPK/p38/Nrf2 is involved in resveratrol alleviating myocardial ischemia-reperfusion injury in diabetic rats as an endogenous antioxidant stress …
  2144. Solasonine alleviates high glucose‐induced podocyte injury through increasing Nrf2‐medicated inhibition of NLRP3 activation
  2145. The gut-microbiota-testis axis mediated by the activation of the Nrf2 antioxidant pathway is related to prepuberal steroidogenesis disorders induced by di-(2-ethylhexyl …
  2146. Dimethyl fumarate alleviates dextran sulfate sodium-induced colitis, through the activation of Nrf2-mediated antioxidant and anti-inflammatory pathways
  2147. Nattokinase attenuates retinal neovascularization via modulation of Nrf2/HO-1 and glial activation
  2148. Activation of nrf2/ho-1 by peptide yd1 attenuates inflammatory symptoms through suppression of tlr4/myyd88/nf-κb signaling cascade
  2149. Protective effect of lemon peel polyphenols on oxidative stress-induced damage to human keratinocyte hacat cells through activation of the nrf2/ho-1 signaling …
  2150. Antiaging function of Chinese pond turtle (Chinemys reevesii) peptide through activation of the Nrf2/Keap1 signaling pathway and its structure-activity …
  2151. Capsaicin prevents contrast-associated acute kidney injury through activation of Nrf2 in mice
  2152. Synthesis and biological evaluation of 1, 2, 4-triazole derivatives as potential Nrf2 activators for the treatment of cerebral ischemic injury
  2153. Hydrogen sulfide protects against ammonia-induced neurotoxicity through activation of Nrf2/ARE signaling in astrocytic model of hepatic encephalopathy
  2154. Effect of combined exposure to environmental aliphatic electrophiles from plants on Keap1/Nrf2 activation and cytotoxicity in HepG2 cells: A model of an electrophile …
  2155. Activation of the PPARγ prevents ferroptosis-induced neuronal loss in response to intracerebral hemorrhage through synergistic actions with the Nrf2
  2156. Discovery of cinnamamide-barbiturate hybrids as a novel class of Nrf2 activator against myocardial ischemia/reperfusion injury
  2157. Immune response gene 1 deficiency impairs Nrf2 activation and aggravates liver fibrosis in mice
  2158. iTRAQ-based quantitative proteomics indicated Nrf2/OPTN-mediated mitophagy inhibits NLRP3 inflammasome activation after intracerebral hemorrhage
  2159. Activation of Nrf2 by Lithospermic Acid Ameliorates Myocardial Ischemia and Reperfusion Injury by Promoting Phosphorylation of AMP-Activated Protein Kinase α …
  2160. Activation of NRF2 and ATF4 Signaling by the Pro-Glutathione Molecule I-152, a Co-Drug of N-Acetyl-Cysteine and Cysteamine
  2161. … /D-Galactosamine-Induced Acute Liver Failure by Upregulating the Nrf2 Pathway and Inhibiting NF-κB, MAPK, and NLRP3 Inflammasome Activation
  2162. Human Placental Extract Delays In Vitro Cellular Senescence through the Activation of NRF2-Mediated Antioxidant Pathway
  2163. NXP032 ameliorates aging-induced oxidative stress and cognitive impairment in mice through activation of Nrf2 signaling
  2164. Ferulic acid induces keratin 6α via inhibition of nuclear β-catenin accumulation and activation of Nrf2 in wound-induced inflammation
  2165. Electrophilic thymol isobutyrate from Inula nervosa Wall.(Xiaoheiyao) ameliorates steatosis in HepG2 cells via Nrf2 activation
  2166. Spermidine inhibits LPS-induced pro-inflammatory activation of macrophages by acting on Nrf2 signaling but not autophagy
  2167. Activation of the Nrf2 response by oleanolic acid oxime morpholide (3-hydroxyiminoolean-12-en-28-oic acid morpholide) is associated with its ability to induce …
  2168. Castor Oil Plant (Ricinus communis L.) Leaves Improve Dexamethasone-Induced Muscle Atrophy via Nrf2 Activation
  2169. Oligo-fucoidan improves diabetes-induced renal fibrosis via activation of sirt-1, glp-1r, and nrf2/ho-1: An in vitro and in vivo study
  2170. Sagittaria sagittifolia polysaccharide protects against six-heavy-metal-induced hepatic injury associated with the activation of Nrf2 pathway to regulate oxidative stress …
  2171. Brain Protection by Methylene Blue and Its Derivative, Azur B, via Activation of the Nrf2/ARE Pathway in Cisplatin-Induced Cognitive Impairment
  2172. Lignans from Eucommia ulmoides Oliver leaves exhibit neuroprotective effects via activation of the PI3K/Akt/GSK-3β/Nrf2 signaling pathways in H2O2-treated PC-12 …
  2173. … chinense Pursh attenuates hepatic ischemia/reperfusion injury by suppressing oxidative stress and inflammation through activation of the Nrf2/HO-1 signaling …
  2174. Acertannin attenuates LPS-induced inflammation by interrupting the binding of LPS to the TLR4/MD2 complex and activating Nrf2-mediated HO-1 activation
  2175. … (Xingxiong injection) protects against focal cerebral ischaemia/reperfusion injury via activating the Akt/Nrf2 pathway and inhibiting NLRP3 inflammasome activation
  2176. Neuroprotective effect of apigenin against hypoxic-ischemic brain injury in neonatal rats via activation of the PI3K/Akt/Nrf2 signaling pathway
  2177. Chlorogenic Acid Activates Nrf2/SKN-1 and Prolongs the Lifespan of Caenorhabditis elegans via the Akt-FOXO3/DAF16a-DDB1 Pathway and Activation of DAF16f
  2178. Early growth response 1 suppresses macrophage phagocytosis by inhibiting NRF2 activation through upregulation of autophagy during Pseudomonas …
  2179. n-BuOH extract of Bletilla striata exerts chemopreventive effects on lung against SiO2 nanoparticles through activation of Nrf2 pathway
  2180. Activation of the Nrf2/HO-1 signaling pathway contributes to the protective effects of platycodin D against oxidative stress-induced DNA damage and apoptosis in …
  2181. Lablab purpureus protects HaCaT cells from oxidative stress-induced cell death through Nrf2-mediated heme oxygenase-1 expression via the activation of p38 and …
  2182. Vernonia patula (Dryand.) Merr. and Leucas chinensis (Retz.) R. Brown exert anti-inflammatory activities and relieve oxidative stress via Nrf2 activation
  2183. Advanced therapeutic inhalation aerosols of a Nrf2 activator and RhoA/Rho kinase (ROCK) inhibitor for targeted pulmonary drug delivery in pulmonary hypertension …
  2184. Diacerein ameliorates kidney injury induced by cisplatin in rats by activation of Nrf2/Ho-1 pathway and Bax down-regulation
  2185. Sulforaphane prevents type 2 diabetes-induced nephropathy via AMPK-mediated activation of lipid metabolic pathways and Nrf2 antioxidative function
  2186. The potential of Nrf2 activation as a therapeutic target in systemic lupus erythematosus
  2187. Suppressive role of microRNA-130b-3p in ferroptosis in melanoma cells correlates with DKK1 inhibition and Nrf2-HO-1 pathway activation
  2188. … cardiomyocytes from hypoxia/reoxygenation‐induced injury by inhibiting apoptosis, oxidative stress, and inflammatory response via enhancing Nrf2/ARE activation
  2189. Polysaccharides extracted from Rheum tanguticum ameliorate radiation-induced enteritis via activation of Nrf2/HO-1
  2190. Hepatoprotective effect of neoagarooligosaccharide via activation of Nrf2 and enhanced antioxidant efficacy
  2191. Eletrophilic chemistry of tranilast is involved in its anti-colitic activity via Nrf2-HO-1 pathway activation
  2192. Saikosaponin-D mitigates oxidation in SH-SY5Y cells stimulated by glutamate through activation of Nrf2 pathway: involvement of PI3K
  2193. Induction of HO-1 by 5, 8-dihydroxy-4, 7-dimethoxyflavone via activation of ROS/p38 MAPK/Nrf2 attenuates thrombin-induced connective tissue growth factor …
  2194. The potential for reducing Lynch syndrome cancer risk with nutritional Nrf2 activators
  2195. Herba houttuyniae Extract Benefits Hyperlipidemic Mice via Activation of the AMPK/PGC-1α/Nrf2 Cascade
  2196. Aloperine protects human retinal pigment epithelial cells against hydrogen peroxide–induced oxidative stress and apoptosis through activation of Nrf2/HO-1 pathway
  2197. Ferulic acid prevents cyclosporine-induced nephrotoxicity in rats through exerting anti-oxidant and anti-inflammatory effects via activation of Nrf2/HO-1 signaling and …
  2198. Novel cudraisoflavone J derivatives as potent neuroprotective agents for the treatment of Parkinson’s disease via the activation of Nrf2/HO-1 signaling
  2199. Cytoprotective effects of fermented oyster extracts against oxidative stress-induced DNA damage and apoptosis through activation of the Nrf2/HO-1 signaling …
  2200. Atractylenolide III attenuates bleomycin-induced experimental pulmonary fibrosis and oxidative stress in rat model via Nrf2/NQO1/HO-1 pathway activation
  2201. Yinhuang oral liquid protects acetaminophen-induced acute liver injury by regulating the activation of autophagy and Nrf2 signaling
  2202. Vitexin attenuates autoimmune hepatitis in mouse induced by syngeneic liver cytosolic proteins via activation of AMPK/AKT/GSK-3β/Nrf2 pathway
  2203. Quercetin supports bovine preimplantation embryo development under oxidative stress condition via activation of the Nrf2 signalling pathway
  2204. Minocycline inhibits sleep deprivation-induced aberrant microglial activation and Keap1-Nrf2 expression in mouse hippocampus
  2205. Betanin ameliorates fipronil-induced nephrotoxicity via activation of Nrf2-HO-1/NQO-1 pathway in albino rat model
  2206. … protective effect of sulforaphane against oxidative stress in granulosa cells of patients with polycystic ovary syndrome (PCOS) through activation of AMPK/AKT/NRF2 …
  2207. α‐Lipoic acid protects against microcystin‐LR induced hepatotoxicity through regeneration of glutathione via activation of Nrf2
  2208. Activation of the Nrf2/HO-1 Pathway by Amomum villosum Extract Suppresses LPS-Induced Oxidative Stress In Vitro and Ex Vivo
  2209. Activation of AdipoR1 with rCTRP9 preserves BBB integrity through the APPL1/AMPK/Nrf2 signaling pathway in ICH mice
  2210. Activation of cannabinoid receptor type 2-induced osteogenic differentiation involves autophagy induction and p62-mediated Nrf2 deactivation
  2211. Design and evaluation of Nrf2 activators with 1, 3, 4-oxa/thiadiazole core as neuro-protective agents against oxidative stress in PC-12 cells
  2212. Glaucocalyxin A protects H9c2 cells against hypoxia/reoxygenation-induced injury through the activation of Akt/Nrf2/HO-1 pathway
  2213. Activation of M3AChR (type 3 muscarinic acetylcholine receptor) and Nrf2 (nuclear factor erythroid 2–related factor 2) signaling by choline alleviates vascular smooth …
  2214. Dieckol alleviates dextran sulfate sodium‐induced colitis via inhibition of inflammatory pathway and activation of Nrf2/HO‐1 signaling pathway
  2215. Dimethyl itaconate protects against lipopolysaccharide-induced endometritis by inhibition of TLR4/NF-κB and activation of Nrf2/HO-1 signaling pathway in …
  2216. … Sargassum horneri Attenuates Glutamate-Induced Neuronal Cell Death and Oxidative Stress through Inhibition of MAPK/NF-κB and Activation of Nrf2/HO-1 Signaling …
  2217. The Keap1/Nrf2-ARE signaling pathway is involved in atrazine induced dopaminergic neurons degeneration via microglia activation
  2218. Impact of the ACE2 activator xanthenone on tacrolimus nephrotoxicity: Modulation of uric acid/ERK/p38 MAPK and Nrf2/SOD3/GCLC signaling pathways
  2219. Spiraeoside protects human cardiomyocytes against high glucose‐induced injury, oxidative stress, and apoptosis by activation of PI3K/Akt/Nrf2 pathway
  2220. Inhibition of CYP2E1 and activation of Nrf2 signaling pathways by a fraction from Entada africana alleviate carbon tetrachloride-induced hepatotoxicity
  2221. Hydrogen Sulfide Donor GYY4137 Rescues NRF2 Activation in Respiratory Syncytial Virus Infection
  2222. Naturally-derived diterpenoid sphaeropsidin C as an activator of Nrf2/ARE pathway and its potential capability of relieving intracellular oxidative stress in …
  2223. … of PHLPP1 ameliorates high glucose-evoked injury in retinal ganglion cells by attenuating apoptosis and oxidative stress through enhancement of Nrf2 activation
  2224. … -related renal fibrosis by inhibition of inflammation mediated by NF-κB and TGF-β1/Smad signaling and suppression of oxidative stress via activation of Nrf2 …
  2225. Bisphenol A stabilizes Nrf2 via Ca2+ influx by direct activation of the IP3 receptor
  2226. Roles of JNK/Nrf2 pathway on hemin-induced heme oxygenase-1 activation in MCF-7 human breast cancer cells
  2227. Soy Isoflavones Protect Neuronal PC12 Cells against Hypoxic Damage through Nrf2 Activation and Suppression of p38 MAPK and AKT–mTOR Pathways
  2228. Akt/GSK3β/Nrf2/HO-1 pathway activation by flurbiprofen protects the hippocampal neurons in a rat model of glutamate excitotoxicity
  2229. … acid, a cyclooxygenase-2 inhibitor, attenuates inflammatory responses by regulating NF-κB Inactivation and Nrf2 activation in lipopolysaccharide-stimulated cells
  2230. Protective effect of USP22 against paraquat-induced lung injury via activation of SIRT1/NRF2 pathway.
  2231. Upregulation of Nrf2 attenuates oxidative stress–induced, complement activation–associated endothelial injury and apoptosis in transplant-associated …
  2232. Tanshinone IIA prevents acetaminophen‐induced nephrotoxicity through the activation of the Nrf2‐Mrp2/4 pathway in mice
  2233. Activation of Atg7-dependent autophagy by a novel inhibitor of the Keap1–Nrf2 protein–protein interaction from Penthorum chinense Pursh. attenuates 6 …
  2234. Activation of Akt‐dependent Nrf2/ARE pathway by restoration of Brg‐1 remits high glucose‐induced oxidative stress and ECM accumulation in podocytes
  2235. H2O2/DEM-Promoted Maft Promoter Demethylation Drives Nrf2/ARE Activation in Zebrafish
  2236. Vinpocetine reduces cisplatin-induced acute kidney injury through inhibition of NF–κB pathway and activation of Nrf2/ARE pathway in rats
  2237. Mogroside V alleviates lipopolysaccharide-induced neuroinflammation via inhibition of TLR4-MyD88 and activation of AKT/AMPK-Nrf2 signaling pathway
  2238. Downregulation of P300/CBP-associated factor protects from vascular aging via Nrf2 signal pathway activation
  2239. Effect of sulfasalazine on endothelium-dependent vascular response by the activation of Nrf2 signalling pathway
  2240. Agmatine-mediated inhibition of NMDA receptor expression and amelioration of dyskinesia via activation of Nrf2 and suppression of HMGB1/RAGE/TLR4/MYD88/NF …
  2241. … japonicus suppresses hepatocyte EMT and HSC activation in vitro and CCl4-provoked liver fibrosis in mice: Roles of its modulatory effects on the Akt/GSK3β/Nrf2 …
  2242. Ribisins and Certain Analogues Exert Neuroprotective Effects through Activation of the Keap1‐Nrf2‐ARE Pathway
  2243. Activation of the melanocortin-1 receptor by NDP-MSH attenuates oxidative stress and neuronal apoptosis through PI3K/Akt/Nrf2 pathway after intracerebral …
  2244. Gut bacterial metabolite Urolithin A inhibits myocardial fibrosis through activation of Nrf2 pathway in vitro and in vivo
  2245. Opuntia ficus indica (L.) fruit extract alleviates oxidative stress through activation of dual oxidases and Keap1/Nrf2 signaling cascades in high-fat-diet associated …
  2246. Artemisia judaica L. diminishes diabetes-induced reproductive dysfunction in male rats via activation of Nrf2/HO-1-mediated antioxidant responses
  2247. Physiological Concentration of H2O2 Supports Dopamine Neuronal Survival via Activation of Nrf2 Signaling in Glial Cells
  2248. Ketone analog of caffeic acid phenethyl ester exhibits antioxidant activity via activation of ERK-dependent Nrf2 pathway
  2249. Activation of Nrf2/HO‐1 signaling pathway attenuates ROS‐mediated autophagy induced by silica nanoparticles in H9c2 cells
  2250. Activation of KEAP1/NRF2 stress signaling involved in the molecular basis of hemin-induced cytotoxicity in human pro-erythroid K562 cells
  2251. … B surface peptide protects against acute lung injury through reducing oxidative stress and endoplasmic reticulum stress via activation of Nrf2/HO-1 signaling …
  2252. Activation of Nrf2 in Mice Causes Early Microvascular Cyclooxygenase-Dependent Oxidative Stress and Enhanced Contractility
  2253. … 2-related factor 2 (Nrf2), protects against the formation of BAPN-induced aneurysms and dissection of the thoracic aorta in mice by inhibiting activation of the ROS …
  2254. Gnaq protects PC12 cells from oxidative damage by activation of Nrf2 and inhibition of NF-kB
  2255. tert‐Butylhydroquinone‐induced formation of high‐molecular‐weight p62: A novel mechanism in the activation of Nrf2‐Keap1
  2256. Identification of Novel Nrf2 Activator via Protein-ligand Interactions as Remedy for Oxidative Stress in Diabetes Mellitus
  2257. Apomorphine reduces A53T α-synuclein-induced microglial reactivity through activation of NRF2 signalling pathway
  2258. Shockwave treatment enhanced extracellular matrix production in articular chondrocytes through activation of the ROS/MAPK/Nrf2 signaling pathway
  2259. HIF-1α and Nrf2 regulates hypoxia induced overexpression of DDAH1 through promoter activation in prostate cancer
  2260. … of ergothioneine in UVA-irradiated human dermal fibroblasts via the inhibition of the AP-1 pathway and the activation of Nrf2-mediated antioxidant genes
  2261. Thioredoxin reductase-1 levels are associated with NRF2 pathway activation and tumor recurrence in non-small cell lung cancer
  2262. Activation of the Nrf2/ARE signaling pathway protects against palmitic acid-induced renal tubular epithelial cell injury by ameliorating mitochondrial reactive …
  2263. Early neurotoxic effects of inorganic arsenic modulate cortical GSH levels associated with the activation of the Nrf2 and NFκB pathways, expression of amino …
  2264. Phytoconstituents of Sansevieria suffruticosa NEBr. Leaves and Its Hepatoprotective Effect via Activation of the NRF2/ARE Signaling Pathway in an Experimentally …
  2265. Apigenin-7-O-β-D-(-6”-p-coumaroyl)-glucopyranoside treatment elicits a neuroprotective effect through GSK-3β phosphorylation-mediated Nrf2 activation
  2266. Paraoxonase 2 protects against oxygen-glucose deprivation/reoxygenation-induced neuronal injury by enhancing Nrf2 activation via GSK-3β modulation
  2267. Trans-anethole Ameliorates Intestinal Injury Through Activation of Nrf2 Signaling Pathway in Subclinical Necrotic Enteritis-Induced Broilers
  2268. … resistance of head and neck squamous cell carcinoma is mediated by EpCAM induction driven by IL-6/p62 associated Nrf2-antioxidant pathway activation
  2269. RTA404, an Activator of Nrf2, Activates the Checkpoint Kinases and Induces Apoptosis through Intrinsic Apoptotic Pathway in Malignant Glioma
  2270. Mistimed H2S upregulation, Nrf2 activation and antioxidant proteins levels in renal tubular epithelial cells subjected to anoxia and reoxygenation
  2271. Guan Xin Dan Shen formulation protects db/db mice against diabetic cardiomyopathy via activation of Nrf2 signaling
  2272. Protective effects of Hirudin against compartment syndrome in rabbits through the activation of Nrf2/HO-1
  2273. Genetic activation of Nrf2 reduces cutaneous symptoms in a murine model of Netherton syndrome
  2274. Parthenolide inhibits lipid accumulation via activation of Nrf2/Keap1 signaling during adipocyte differentiation
  2275. Activation of GPR39 with TC-G 1008 attenuates neuroinflammation via SIRT1/PGC-1α/Nrf2 pathway post-neonatal hypoxic–ischemic injury in rats
  2276. Activation of Nrf2 by lead sulfide nanoparticles induces impairment of learning and memory
  2277. Formononetin attenuates Aβ25-35-induced adhesion molecules in HBMECs via Nrf2 activation
  2278. Arsenite inhibits tissue-type plasminogen activator synthesis through NRF2 activation in cultured human vascular endothelial EA. hy926 cells
  2279. Shinorine ameliorates chromium induced toxicity in zebrafish hepatocytes through the facultative activation of Nrf2-Keap1-ARE pathway
  2280. … against Oxidative Stress by Methylnissolin-3-O-β-d-glucopyranoside from Astragalus membranaceus Mainly via the Activation of the Nrf2/HO-1 Pathway
  2281. … of Sansevieria trifasciata hort ex. Prain leaves and roots by HPLC-PAD-ESI/MS and its hepatoprotective effect via activation of the NRF2/ARE signaling pathway in an …
  2282. … of endotoxin-induced acute lung injury in rats by bone marrow–derived mesenchymal stem cells: Role of Nrf2/HO-1 signal axis in inhibition of NLRP3 activation
  2283. Activation of Nrf2 signaling by apelin attenuates renal ischemia reperfusion injury in diabetic rats
  2284. … ) protects against high glucose-induced apoptosis, oxidative stress and inflammatory response in retinal ganglion cells by enhancing Nrf2 activation via regulation of …
  2285. Activation of the PDGFRα-Nrf2 pathway mediates impaired adipocyte differentiation in bone marrow mesenchymal stem cells lacking Nck1
  2286. 6-Shogaol protects human melanocytes against oxidative stress through activation of the Nrf2-antioxidant response element signaling pathway
  2287. Arctiin suppresses H9N2 avian influenza virus-mediated inflammation via activation of Nrf2/HO-1 signaling
  2288. Activation of Nrf2 by methylene blue is associated with the neuroprotection against MPP+ induced toxicity via ameliorating oxidative stress and mitochondrial …
  2289. Synthesis and Anti‐Inflammatory Activity of 2‐Amino‐4,5,6,7‐tetrahydrobenzo[b]thiophene‐Derived NRF2 Activators
  2290. Apigenin attenuates high-fat diet-induced nephropathy in rats by hypoglycemic and hypolipidemic effects, and concomitant activation of the Nrf2/antioxidant …
  2291. Protective effect of MitoQ on oxidative stress-mediated senescence of canine bone marrow mesenchymal stem cells via activation of the Nrf2/ARE pathway
  2292. Melatonin attenuates restenosis after vascular injury in diabetic rats through activation of the Nrf2 signaling pathway
  2293. Mn-TAT PTD-Ngb ameliorates inflammation through the elimination of damaged mitochondria and the activation of Nrf2-antioxidant signaling pathway
  2294. Curcumin activation of nuclear factor E2-related factor 2 gene (Nrf2): Prophylactic and therapeutic effect in nonalcoholic steatohepatitis (NASH)
  2295. 1, 25-Dihydroxyvitamin D3 attenuates IL-1β secretion by suppressing NLRP1 inflammasome activation by upregulating the NRF2-HO-1 pathway in epidermal …
  2296. Sestrin2 protects against traumatic brain injury by reinforcing the activation of Nrf2 signaling
  2297. Near-infrared Nrf2 activator IR-61 dye alleviates radiation-induced lung injury
  2298. S-Allylcysteine Protects Against Excitotoxic Damage in Rat Cortical Slices Via Reduction of Oxidative Damage, Activation of Nrf2/ARE Binding, and BDNF …
  2299. Protective effects of sulforaphane on type 2 diabetes-induced cardiomyopathy via AMPK-mediated activation of lipid metabolic pathways and NRF2 function
  2300. Nrf2/ARE pathway activation is involved in negatively regulating heat-induced apoptosis in non-small cell lung cancer cells
  2301. Activation of Nrf2 decreases bile acid concentrations in livers of female mice
  2302. Compensatory expression of NRF2-dependent antioxidant genes is required to overcome the lethal effects of Kv11. 1 activation in breast cancer cells and …
  2303. Suppression of bromodomain-containing protein 4 protects trophoblast cells from oxidative stress injury by enhancing Nrf2 activation
  2304. Ellagic acid improved diabetes mellitus-induced testicular damage and sperm abnormalities by activation of Nrf2
  2305. Cerevisterol alleviates inflammation via suppression of MAPK/NF-κB/AP-1 and activation of the Nrf2/HO-1 signaling cascade
  2306. The protective effect of isoliquiritigenin against doxorubicin-induced nephropathy in rats entails activation of Nrf2 signaling as one key mechanism
  2307. The role of transcription factor Ap1 in the activation of the Nrf2/ARE pathway through TET1 in diabetic nephropathy
  2308. Nrf2 axis and endoplasmic reticulum stress mediated autophagy activation is involved in molybdenum and cadmium co-induced hepatotoxicity in ducks
  2309. Epigallocatechin 3-Gallate has a neuroprotective effect in retinas of rabbits with ischemia/reperfusion through the activation of Nrf2/HO-1
  2310. GSKIP protects cardiomyocytes from hypoxia/reoxygenation-induced injury by enhancing Nrf2 activation via GSK-3β inhibition
  2311. Activation of Nrf2/HO-1 antioxidant pathway by heme attenuates calcification of human lens epithelial cells
  2312. Evaluating skin cancer chemopreventive potential of water extract of Syzygium samarangense leaves through activation of the Nrf2-mediated cellular defense …
  2313. Cryptotanshinone protects hippocampal neurons against oxygen-glucose deprivation-induced injury through the activation of Nrf2/HO-1 signaling pathway
  2314. α-Bisabolol Attenuates NF-κB/MAPK Signaling Activation and ER-Stress-Mediated Apoptosis by Invoking Nrf2-Mediated Antioxidant Defense Systems against …
  2315. Oridonin attenuates carrageenan-induced pleurisy via activation of the KEAP-1/Nrf2 pathway and inhibition of the TXNIP/NLRP3 and NF-κB pathway in mice
  2316. Berberine attenuates cholesterol accumulation in macrophage foam cells by suppressing AP-1 activity and activation of the Nrf2/HO-1 pathway
  2317. Rosemary extract reverses oxidative stress through activation of Nrf2 signaling pathway in hamsters fed on high fat diet and HepG2 cells
  2318. lncRNA Eif4g2 improves palmitate-induced dysfunction of mouse β-cells via modulation of Nrf2 activation
  2319. … Effects of Heterotrigona itama (Stingless Bee) Bee Bread in Improving Hepatic Lipid Metabolism through the Activation of the Keap1/Nrf2 Signaling Pathway in an …
  2320. … of a Natural Flavanol 3,3′-Diindolylmethane against CCl4-Induced Chronic Liver Injury in Mice and TGFβ1-Induced EMT in Mouse Hepatocytes via Activation of Nrf2 …
  2321. … from Potentilla fragarioides ameliorates high glucose-induced oxidative stress and accumulation of ECM in mesangial cells via Keap1-dependent activation of Nrf2
  2322. Proteomic examination of Cornus officinalis stimulated 1.1 B4 human pancreatic cells reveals activation of autophagy and Keap1/Nrf2 pathway
  2323. The antibiotic cefotaxime works as both an activator of Nrf2 and an inducer of HSP70 in mammalian cells
  2324. … Oxidative Stress-Induced Apoptosis by Fermented Sea Tangle (Laminaria japonica Aresch) in Osteoblastic MC3T3-E1 Cells through Activation of Nrf2 …
  2325. C1q/TNF-related Protein 9 Inhibits High Glucose–Induced Oxidative Stress and Apoptosis in Retinal Pigment Epithelial Cells Through the Activation of AMPK/Nrf2 …
  2326. Schisandra chinensis (Turcz.) Baill. essential oil exhibits antidepressant-like effects and against brain oxidative stress through Nrf2/HO-1 pathway activation
  2327. Coptisine ameliorates renal injury in diabetic rats through the activation of Nrf2 signaling pathway
  2328. D-Cysteine Activates Chaperone-Mediated Autophagy in Cerebellar Purkinje Cells via the Generation of Hydrogen Sulfide and Nrf2 Activation
  2329. Identification of Nrf2 Activators from the Roots of Valeriana officinalis
  2330. NRF2 activation by 2-methoxycinnamaldehyde attenuates inflammatory responses in macrophages via enhancing autophagy flux
  2331. Methamphetamine and HIV-1 Tat proteins synergistically induce microglial autophagy via activation of the Nrf2/NQO1/HO-1 signal pathway
  2332. Harpagophytum procumbens Inhibits Iron Overload-Induced Oxidative Stress through Activation of Nrf2 Signaling in a Rat Model of Lumbar Spinal Stenosis
  2333. Semisynthetic quercetin-quinone mitigates BV-2 microglia activation through modulation of Nrf2 pathway
  2334. Activation of the Nrf2 pathway prevents mitochondrial dysfunction induced by caspase-3 cleaved tau: implications for Alzheimer’s disease
  2335. Nrf2 Activation Enhances Muscular MCT1 Expression and Hypoxic Exercise Capacity.
  2336. Nrf2/Keap1-pathway activation and reduced susceptibility to chemotherapy treatment by acidification in esophageal adenocarcinoma cells
  2337. Keap1-targeting microRNA-941 protects endometrial cells from oxygen and glucose deprivation-re-oxygenation via activation of Nrf2 signaling
  2338. Olive oil promotes the survival and migration of dermal fibroblasts through Nrf2 pathway activation.
  2339. … Hyperplasia In Vivo and Vascular Smooth Muscle Cell Dedifferentiation, Proliferation, and Migration In Vitro via Activation of the Keap1-Nrf2-ARE Antioxidant System
  2340. NRF2 Activation in Autophagy Defects Suppresses a Pharmacological Transactivation of the Nuclear Receptor FXR
  2341. Nrf2 Mediated Heme Oxygenase-1 Activation Contributes to Diabetic Wound Healing–an Overview
  2342. Quercetin protects the buffalo rat liver (BRL-3A) cells from aflatoxin B1-induced cytotoxicity via activation of Nrf2-ARE pathway
  2343. Aldosterone Induces DNA Damage and Activation of Nrf2 Mainly in Tubuli of Mouse Kidneys
  2344. … oxygen‑glucose deprivation/reperfusion injury by inhibiting oxidative stress and inflammatory response via the activation of SIRT1/Nrf2 signaling pathway in …
  2345. … Human In Vitro Intestinal Microbial Conversion of Green Tea (‐)‐Epigallocatechin‐3‐O‐Gallate and Consequences for Activation of Nrf2 Mediated Gene Expression
  2346. Isoorientin Alleviates Inflammatory Bowel Disease by Inhibiting NLRP3 Inflammasome Activation through Nrf2/NQO1 Pathway.
  2347. Activation of the Nrf2 Antioxidant Pathway by Longjing Green Tea Polyphenols in Mice Livers
  2348. SARS-CoV-2 virus NSP14 Impairs NRF2/HMOX1 activation by targeting Sirtuin 1
  2349. Exendin-4 protects human retinal pigment epithelial cells from H2O2-induced oxidative damage via activation of NRF2 signaling
  2350. Ephedrine ameliorates cerebral ischemia injury via inhibiting NOD-like receptor pyrin domain 3 inflammasome activation through the Akt/GSK3β/NRF2 pathway
  2351. ALK7 Knockdown Plays a Protective Role on HG-Stimulated MCs through Activation of the Nrf2/HO-1 Pathway
  2352. Identification and optimization of piperine analogues as neuroprotective agents for the treatment of Parkinson’s disease via the activation of Nrf2/keap1 pathway
  2353. Trehalose prevents glyphosate-induced hepatic steatosis in roosters by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation
  2354. Metabolic activation of retrorsine may disrupt bile acid homeostasis in mice through the Nrf2 pathway
  2355. Dual proteotoxic stress accelerates liver injury via activation of p62‐Nrf2
  2356. Edaravone dexborneol alleviates cerebral ischemic injury via MKP-1-mediated inhibition of MAPKs and activation of Nrf2
  2357. Green tea polyphenols cause apoptosis and autophagy in HPV-16 subgene-immortalized human cervical epithelial cells via the activation of the Nrf2 pathway
  2358. Oxyresveratrol-induced activation of Nrf2/HO-1 signaling pathway enhances ability of resveratrol to inhibit UVB-induced melanin
  2359. NOX4 stimulates ANF secretion via activation of the Sirt1/Nrf2/ATF3/4 axis in hypoxic beating rat atria
  2360. Ischemic postconditioning-mediated DJ-1 activation mitigate intestinal mucosa injury induced by myocardial ischemia reperfusion in rats through Keap1/Nrf2 …
  2361. Identification of a potent Nrf2 displacement activator among aspirin-containing prodrugs
  2362. Human papillomavirus 16 E7 promotes EGFR/PI3K/AKT1/NRF2 signaling pathway contributing to PIR/NF-κB activation in oral cancer cells
  2363. Ginsenoside Rb1 Attenuates Triptolide-Induced Cytotoxicity in HL-7702 Cells via the Activation of Keap1/Nrf2/ARE Pathway
  2364. (±)-5-bromo-2-(5-fluoro-1-hydroxyamyl) Benzoate Protects Against Oxidative Stress Injury in PC12 Cells Exposed to H2O2 Through Activation of Nrf2 …
  2365. … Alzheimer’s disease progression and prevents the exacerbation of cardiovascular dysfunction of socially isolated depressed rats through activation of Nrf2/HO-1 and …
  2366. 7-deacetyl-gedunin suppresses proliferation of Human rheumatoid arthritis synovial fibroblast through activation of Nrf2/ARE signaling
  2367. … of leaf and branch extracts of honeyberry (Lonicera caerulea) on lipopolysaccharide‑stimulated RAW264. 7 cells through ATF3 and Nrf2/HO‑1 activation
  2368. Notoginsenoside R1 alleviates TEGDMA-induced mitochondrial apoptosis in preodontoblasts through activation of Akt/Nrf2 pathway-dependent mitophagy
  2369. Hepatocyte-Specific Deficiency of BAP31 Amplified Acetaminophen-Induced Hepatotoxicity via Attenuating Nrf2 Signaling Activation in Mice
  2370. Catalpol protects arpe-19 cells against oxidative stress via activation of the keap1/nrf2/are pathway
  2371. … impairment of late-stage autophagic flux in murine splenocytes leads to sqstm1/p62 mediated nrf2-keap1 antioxidant pathway activation and induced proteasome …
  2372. Comparative effectiveness of 4 natural and chemical activators of Nrf2 on inflammation, oxidative stress, macrophage polarization, and bactericidal activity in …
  2373. Mechanisms and therapeutic implications of RTA 408, an activator of Nrf2, in subarachnoid hemorrhage–induced delayed cerebral vasospasm and …
  2374. Sevoflurane preconditioning prevents acute renal injury caused by ischemia‑reperfusion in mice via activation of the Nrf2 signaling pathway
  2375. CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes
  2376. Neuroprotective Effects of Rhynchophylline Against Aβ1–42-Induced Oxidative Stress, Neurodegeneration, and Memory Impairment Via Nrf2–ARE Activation
  2377. Protective Effect of Alpinia oxyphylla Fruit against tert-Butyl Hydroperoxide-Induced Toxicity in HepG2 Cells via Nrf2 Activation and Free Radical Scavenging …
  2378. Diastereoselective Copper-Mediated Conjugate Addition of Functionalized Magnesiates for the Preparation of Bisaryl Nrf2 Activators
  2379. Carvedilol and rosuvastatin mitigate nephrotoxicity of sodium valproate through activation of Nrf2 pathway in rats.
  2380. Nrf2 Activation in Chronic Kidney Disease: Promises and Pitfalls. Antioxidants 2022, 11, 1112
  2381. Inhibition of MRP1 Induces Fetal Hemoglobin through NRF2 Activation to Protect Human Erythroid Cells from Sickling
  2382. Methyl 6-O-cinnamoyl-α-d-glucopyranoside ameliorates acute liver injury by inhibiting oxidative stress through the activation of Nrf2 signaling pathway
  2383. TBHQ attenuates ferroptosis against 5-fluorouracil-induced intestinal epithelial cell injury and intestinal mucositis via activation of Nrf2
  2384. QSAR study, molecular docking, and ADMET prediction of vinyl sulfone-containing Nrf2 activator derivatives for treating Parkinson disease
  2385. The anti-inflammatory activities of twelve Nigerian medicinal plants: Inhibition of NfkB, activation of Nrf2, and antioxidant content
  2386. L-carnitine mitigates bisphenol A-induced hepatic toxicity via activation of Nrf2 and inhibition of pro-inflammatory cytokine gene expression in rats
  2387. Correction to: novel biphenyl diester derivative AB-38b inhibits NLRP3 inflammasome through Nrf2 activation in diabetic nephropathy
  2388. Nicotinamide adenine dinucleotide attenuates acetaminophen-induced acute liver injury via activation of PARP1, Sirt1, and Nrf2 in mice
  2389. … against pyroptosis to attenuate sevoflurane inhalation-induced post-operative cognitive dysfunction in rats via activation of HTR2A/ERK/Nrf2 axis by targeting …
  2390. In-silico study of Marselia crenata compounds as activator Keap1/Nrf2 pathway in ovarian function
  2391. Fucoxanthin suppresses OxLDL-induced inflammation via activation of Nrf2 and inhibition of NF-κB signaling
  2392. Docosahexaenoic acid induces expression of NAD (P) H: quinone oxidoreductase and heme oxygenase-1 through activation of Nrf2 in cerulein-stimulated pancreatic …
  2393. Sikyungbanha-Tang suppressing acute lung injury in mice is related to the activation of Nrf2 and TNFAIP3
  2394. Design, Synthesis and Pharmacological Evaluation of N‐Benzyl Linoleamide Analogues from Tropaeolum tuberosum as NF‐κB Inhibitors and Nrf2 Activators
  2395. Activation of the Nrf2/GPX4 Signaling by Pratensein From Trifolium pretense Mitigates Ferroptosis in OGD/R-Insulted H9c2 Cardiomyocytes
  2396. Phytochemical Nrf2 activator attenuates skeletal muscle mitochondrial dysfunction and impaired proteostasis in a preclinical model of musculoskeletal aging
  2397. Nrf2 Activation Improves Mitochondrial Function in Kidneys of Aged F344 Rats
  2398. MEF2D upregulation protects neurons from oxygen–glucose deprivation/re-oxygenation-induced injury by enhancing Nrf2 activation
  2399. Assessment and characterization of tomato lipophilic electrophiles and their potential contribution to nutraceutical properties via SKN-1/Nrf2 signaling activation
  2400. SOCS3-mediated activation of p53-p21-NRF2 axis and cellular adaptation to oxidative stress in SOCS1-deficient hepatocellular carcinoma
  2401. … attenuated oxidative stress-induced cellular damage in ARPE-19 human retinal pigment epithelial cells through Nrf2-mediated activation of heme oxygenase …
  2402. Analogs of imine resveratrol alleviate oxidative stress‐induced neurotoxicity in PC12 cells via activation of Nrf2
  2403. 5-Methyltetrahydrofolate Attenuates Oxidative Stress and Improves Kidney Function in Acute Kidney Injury through Activation of Nrf2 and Antioxidant Defense
  2404. The Temporal and Contextual Relationship of NRF2 Activation and Cancer
  2405. … neuronal derangements and kidney disturbances in streptozotocin-induced diabetic nephropathy via concomitant activation of Nrf2/Bcl-2/antioxidants axis
  2406. IL-20R Activation via rIL-19 Enhances Hematoma Resolution through the IL-20R1/ERK/Nrf2 Pathway in an Experimental GMH Rat Pup Model
  2407. NRF2/HO-1 pathway activation by ATF3 in a noise-induced hearing loss murine model
  2408. Identification of novel and potent Nrf2 activators from medicinal plants
  2409. … from Salicornia herbacea L. on Lipopolysaccharide-Stimulated Murine Macrophage via NF-kB and MAPK Inhibition and Nrf2/HO-1 Signaling Activation
  2410. Protection Against Post-resuscitation Acute Kidney Injury by N-Acetylcysteine via Activation of the Nrf2/HO-1 Pathway
  2411. RTA‐408 protects against propofol‐induced cognitive impairment in neonatal mice via the activation of Nrf2 and the inhibition of NF‐κB p65 nuclear translocation
  2412. Neuroprotective Effect of WYY026B on Cerebral Ischemia/Reperfusion Injury in Rodents Through Activation of Nrf2/HO-1 Pathway
  2413. Knockdown of IL-32 protects PC12 cells against oxygen-glucose deprivation/reoxygenation-induced injury via activation of Nrf2/NF-κB pathway
  2414. … peptide protects vertebral endplate chondrocytes against H2O2‑induced apoptosis and oxidative stress through activation of the Nrf2/HO‑1 signaling …
  2415. Fraxin Promotes the Activation of Nrf2/ARE Pathway via Increasing the Expression of Connexin43 to Ameliorate Diabetic Renal Fibrosis
  2416. Petatewalide B alleviates oxygen‑glucose deprivation/reoxygenation‑induced neuronal injury via activation of the AMPK/Nrf2 signaling pathway
  2417. Tiron alleviates MPTP‐induced Parkinsonism in mice via activation of Keap‐1/Nrf2 pathway
  2418. Evodiamine attenuates cadmium-induced nephrotoxicity through activation of Nrf2/HO-1 pathway
  2419. Activation of nrf2/NQO1 pathway attenuates oxidative stress in neuronal cells induced by microwave and protects neurite development
  2420. … ) phenyl) furan-2-carboxamide (BK3C231) induces cytoprotection in CCD18-Co human colon fibroblast cells through Nrf2/ARE pathway activation
  2421. Elevation of chemosensitivity of lung adenocarcinoma a549 spheroid cells by Claudin-2 knockdown through activation of glucose transport and inhibition of Nrf2 …
  2422. trans-Cinnamaldehyde prevents oxidative stress-induced apoptosis in V79-4 Chinese hamster lung fibroblasts through the Nrf2-mediated HO-1 activation
  2423. Review on role of nrf2 pathway activation in neurological disorder
  2424. n-3 Polyunsaturated fatty acid-enriched phosphatidylglycerol suppresses inflammation in RAW264. 7 cells through Nrf2 activation via alteration of fatty acids in cellular …
  2425. Opioid-sparing Effects of the Nrf2 Activator Diroximel Fumarate in Mice
  2426. … EFFECTS OF ISOLIQUIRITIN ON BEAS-2B CELLS AGAINST LPS-INDUCED OXIDATIVE STRESS AND INFLAMMATION INVOLVING ACTIVATION OF NRF2
  2427. Keap1-Nrf2 signaling activation by Bardoxolone-methyl ameliorates high glucose-induced oxidative injury in human umbilical vein endothelial cells
  2428. Molecular hydrogen protects against oxidative stress-induced RAW 264.7 macrophage cells through the activation of Nrf2 and inhibition of MAPK signaling pathway
  2429. Costunolide Protects Myocardial from Ischemia Reperfusion Injury through Nrf2 Activation
  2430. Modulation of Nrf2 by activation of estrogen receptor β as a therapeutic strategy to prevent cancer development and overcome inflammation-related drug resistance in …
  2431. NRF2 Activation by KEAP1 Inhibition Induces Fetal Hemoglobin and Regulates Antioxidant Response in Erythroid Cells
  2432. Bdh1-Mediated βOHB Metabolism Ameliorates Diabetic Kidney Disease by Activation of Nrf2-Mediated Antioxidative Pathway
  2433. Anti-Inflammatory and Anti-Oxidant Effects of Epilobium amurense subsp. cephalostigma via Activation of Nrf2/HO-1 and Inhibition of NF-κB/p38 MAPK …
  2434. Activation of intracellular antioxidant master gene Nrf2 by the extracts of Garcinia subelliptica, Ocimum gratissimum L., and Plectranthus ornatus
  2435. 15-Keto prostaglandin E2 induces heme oxygenase-1 expression through activation of Nrf2 in human colon epithelial CCD 841 CoN cells
  2436. Oxidative Stress and Nrf2 Activation in Dogs
  2437. Activation of the Keap1-Nrf2 pathway by specioside and the n-butanol extract from the inner bark of Tabebuia rosea (Bertol) DC
  2438. Correction to: novel biphenyl diester derivative AB-38b inhibits NLRP3 inflammasome through Nrf2 activation in diabetic nephropathy.
  2439. Lentinan alleviates arsenic-induced hepatotoxicity in mice via downregulation of OX40/IL-17A and activation of Nrf2 signaling
  2440. Ellagic Acid Protects from Rotenone-Induced Dopaminergic Neuronal Damage via Activation of Nrf2 Signaling in Astroglia
  2441. Activation of NRF2 Pathways in Glaucoma
  2442. Rosiglitazone ameliorates acute hepatic injury via activating the Nrf2 signaling pathway and inhibiting activation of the NLRP3 inflammasome
  2443. Activation of α7 nicotinic acetylcholine receptor by its selective agonist improved learning and memory of amyloid precursor protein/presenilin 1 (APP/PS1) …
  2444. Arsenite induces tissue factor synthesis through Nrf2 activation in cultured human aortic smooth muscle cells
  2445. Nuclear factor erythroid 2-related factor 2 (NRF2) is a negative regulator of tissue plasminogen activator synthesis in cultured human vascular endothelial EA. hy926 …
  2446. Research Article Nrf2 Activation Mediates Antiallodynic Effect of Electroacupuncture on a Rat Model of Complex Regional Pain Syndrome Type-I through …
  2447. High Glucose Enhances Skin Sensitizer-induced NRF2 Activation In Vitro
  2448. The Impact of the NRF2 Activators Arsenic Trioxide and Tert Butylhydroquinone on B Cell Function
  2449. The Keap1/Nrf2/ARE system activators do not increase cardiac resistance to long-term ischemia/reperfu-sion
  2450. … (Mertens) Kuntze Prevents Oxidative Stress-Induced Cellular Damage in V79-4 Chinese Hamster Lung Fibroblasts through the Activation of the Nrf2/HO-1 Signaling …
  2451. Modulators of Nrf2 Activation During Inflammation
  2452. Apigenin exerts chemopreventive effects on lung injury induced by SiO2 nanoparticles through the activation of Nrf2
  2453. ANTIOXIDANT EFFECT OF SPINACH EXTRACT IN LIVER FIBROGENESIS ASSOCIATED TO ACTIVATION OF NRF2/HO-1 IN HYPERGLYCEMIC RATS
  2454. The Role of Car and Nrf2 Dual Activation in Doxorubicin/Cyclophosphamide-Based Treatment of Triple Negative Breast Cancer
  2455. Clinical Research Progress of NRF2 Activators in the Treatment of Age-related Diseases
  2456. Inhibition of sphingomyelin synthase 2 relieves hypoxia-induced cardiomyocyte injury by reinforcing Nrf2/ARE activation via modulation of GSK-3β
  2457. TPNA10168, an Nrf-2 activator, attenuates inflammatory responses independently of Nrf2 in microglial BV-2 cells: Involvement of the extracellular-signal …
  2458. Eriodictyol ameliorated cognitive dysfunction in APP/PS1 mice through inhibited ferroptosis via vitamin D receptor mediated Nrf2 activation
  2459. Extracts and Steroids from the Edible Mushroom Hypholoma lateritium Exhibit Anti‐Inflammatory Properties by Inhibition of COX‐2 and Activation of Nrf2
  2460. Small Molecules for NRF2 Activation and Analytical Techniques to Visualize Cell Permeability
  2461. Nrf2 Activator PB125® as a Potential Therapeutic
  2462. Spinosin Attenuates Osteoclastogenesis through Suppressing NF-Κb by the Activation of Nrf2/HO-1 Signaling in Osteoporosis
  2463. Could targeting miRNA-142-5p be a therapeutic strategy against COVID-19 through activation of the anti-inflammatory Nrf2/Keap1 pathway?
  2464. Aloperine attenuates high glucose-induced oxidative injury in Schwann cells via activation of NRF2/HO-1 pathway
  2465. Nutraceutical Activation of the Transcription Factor Nrf2 as a Potential Approach for Modulation of Aging
  2466. The modulatory effects of Nrf2 activators in a pulmonary arterial hypertension model
  2467. Modulatory Effects of Cilostazol; an Nrf2/HO-1 activator against NAFLD in Rats Confirmed by Molecular Docking and FTIR Studies
  2468. Hesperetin protects SH-SY5Y cells against 6-hydroxydopamine-induced neurotoxicity via activation of NRF2/ARE signaling pathways
  2469. Impact of the NRF2 activator, stabilised synthetic sulforaphane, on systemic inflammation in COVID19: results from the STAR-COVID19 trial
  2470. Dexmedetomidine alleviates inflammation-induced neuropathic pain by suppressing NLRP3 via activation of Nrf2
  2471. Therapeutic potential of oxymatrine in impeding the cardiomyopathy in the STZ-nicotinamide induced diabetes through SIRT1/Nrf2 signaling activation
  2472. Polysaccharide From Laminaria Japonica Attenuates Radiation-Induced Xerostomia In Mice Via Activation of Nrf2 Signaling Pathway
  2473. Neuroprotective Effects of Rhynchophylline Against Aβ1–42-Induced Oxidative Stress, Neurodegeneration, and Memory Impairment Via Nrf2–ARE Activation
  2474. Compensatory Activation of Nrf2 in Endothelial Cells inhibits Atherosclerosis through Limiting Inflammation and Lipid Peroxidation
  2475. The effects of Nrf2 activators and oxidative stress on COPD alveolar macrophages
  2476. Elucidation of the respective roles of itaconate and nitric oxide in the nuclear accumulation and activation of Nrf2 in activated macrophages
  2477. Kaurenoic acid, a natural substance from traditional herbal medicine, alleviates palmitate induced hepatic lipid accumulation via Nrf2 activation
  2478. Sulfiredoxin-1 inhibits PDGF-BB-induced vascular smooth muscle cell proliferation and migration by enhancing the activation of Nrf2/ARE signaling
  2479. … attenuates secondary brain injury following intracerebral hemorrhage by inhibiting NLRP3 inflammasome activation and promoting Nrf2/ARE signaling pathway in …
  2480. Targeting Skeletal Muscle Mitochondrial Function with a Nrf2 Activator in a Novel Model of Musculoskeletal Decline
  2481. Toxicity of new monophenolic synthetic activator of Keap1/Nrf2/ARE redox-sensitive signaling system in vitro and in vivo
  2482. The Role of Nrf2 Activation on the Murine T Cell Response to Influenza Infection
  2483. Maslinic Acid Alleviates Atherosclerosis by Suppressing Mitochondrial ROS-Dependent NLRP3 Inflammasome Activation in Vascular Endothelial Cells via SIRT1/Nrf2 …
  2484. Intraperitoneal injection of Nrf2 activator inhibited calvarial bone destruction in mice
  2485. Nrf2 activator-encapsulating polymeric nanoparticles and LDL-like nanoparticles target atherosclerotic plaque
  2486. Author Correction: Moderate Nrf2 Activation by Genetic Disruption of Keap1 Has Sex-Specific Effects on Bone Mass in Mice
  2487. IMR-261, a Novel Oral Nrf2 Activator, Induces Fetal Hemoglobin in Human Erythroblasts, Reduces VOCs, and Ameliorates Ineffective Erythropoiesis in …
  2488. deprivation/reoxygenation‑induced neuronal injury via activation of the AMPK/Nrf2 signaling pathway
  2489. AITC induces MRP1 expression by protecting against CS/CSE-mediated DJ-1 protein degradation via activation of the DJ-1/Nrf2 axis
  2490. Activation of NRF2/HO-1 Pathway by aqueous methanolic leaf extract of Triclisia gilletii and selected identified compounds in Triclisia gilletii, modulates crystal …
  2491. … inflammatory mediator effects in LPS-induced macrophage and microglial cells by regulating BACH1 and HO-1/Nrf2 signals through inhibition of TLR4 activation
  2492. To each their own: Disparate abilities of Nrf2 activators to protect against various electrophilic and oxidative insults
  2493. Pathological Analyses in Constitutive Nrf2 Activation in The Liver
  2494. Antioxidant status of blood plasma of acutely psychotic patients and its correlation with Nrf2 activation
  2495. Activation of Nrf2‐mediated protective pathways by nature‐inspired hybrids improves proteostasis in retinal pigment epithelial cells
  2496. Correction to: Nrf2 activation through the PI3K/GSK-3 axisprotects neuronal cells from Aβ-mediatedoxidative and metabolic damage
  2497. Repurposing dimethyl fumarate? In vitro evidence of Nrf2‐pathway activation and cytoprotective effects in human retinal endothelial cells
  2498. Evaluation of antioxidant activation by potential nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/Keap1 complex inhibitors
  2499. Z-ligustilide reduces cisplatin-induced nephrotoxicity via activation of NRF2/HO-1 signaling pathways
  2500. Nrf2 activator Sulforaphane attenuates maternal adiposity and hepatic steatosis
  2501. 391-P: The Nrf2 Activator Increases TFAM and Suppresses STING in Human Renal Proximal Tubular Cells
  2502. Activation of Nrf2 By Genetic Alteration of Keap1 Confers Resistance to Chemotherapy in Head and Neck Squamous Carcinoma
  2503. Correction: The anti-arthritis effect of sulforaphane, an activator of Nrf2, is associated with inhibition of both B cell differentiation and the production of inflammatory …
  2504. Anti-Inflammatory and Antioxidant Effects of Epilobium Amurense Subsp. Cephalostigma (Hausskn.) CJ Chen, Hoch & PH Raven via Activation of Nrf2/HO-1 and …
  2505. TRIB3 promotes lung cancer cell survival and inhibits apoptosis through NRF2 activation
  2506. Corrigendum to “Maggot Extracts Alleviate Inflammation and Oxidative Stress in Acute Experimental Colitis via the Activation of Nrf2”
  2507. Possibility of NRF2 Activation as a Priming Tool Against SARS-COV-2 Infection
  2508. Cancer cachexia‐mediated regulation of EcSOD synthesis requires Nrf2 activation by p62 phosphorylation
  2509. Activation of Nrf2 Fails to Protect from Ischemia-reperfusion Cardiac Injury
  2510. Activation of Nrf2/ARE signal pathway reduces radiotherapy-induced tissue injury
  2511. Nrf2 activator relieves pulmonary vascular remodeling in rats with hypoxic pulmonary arterial hypertension
  2512. Tetramethylpyrazine nitrone exerts neuroprotection via PGC-1α/Nrf2 activation and α-synuclein clearance in Parkinson’s disease models
  2513. Therapeutic Nrf2 Activation improves LV function in the cardiomyocyte‐specific GPER knockdown mouse
  2514. P1560: IMR-261, A NOVEL, ORAL NRF2 ACTIVATOR, REDUCES IRON OVERLOAD IN AN EXPERIMENTAL MOUSE MODEL BY ACTIVATING BMP6-MEDIATED …
  2515. The Role of Nuclear Factor Erythroid 2-Related Factor 2 (NRF2) in Preventing Inflammasome Activation in Peripheral Nerve Injury
  2516. Activation of Transcription Factor Nrf2 Ameliorates Age‐Associated Decline in Kidney Function
  2517. Study on the mechanism underlying activation of Nrf2/SKN-1 and lifespan elongation in Caenorhabditis elegans by chlorogenic acid
  2518. Activation of NRF2 Blocks HIV Replication and Apoptosis in Macrophages
  2519. Activation of Nrf2 at Critical Windows of Development Alters Protein S-Glutathionylation in the Zebrafish Embryo (Danio rerio)
  2520. The cadmium altered oxidative homeostasis leads to energetic metabolism rearrangement, Nrf2 activation with increased GSH production and reduced SOD1 activity …
  2521. Publisher Correction: Extracellular Hsp90α stimulates a unique innate gene profile in microglial cells with simultaneous activation of Nrf2 and protection from oxidative …
  2522. Costunolide protects myocardium from ischemia reperfusion injury by inhibiting oxidative stress through Nrf2/Keap1 pathway activation
  2523. Retraction Note: Activation of PERK-Nrf2 oncogenic signaling promotes Mdm2-mediated Rb degradation in persistently infected HCV culture
  2524. Activation of NRF2 signaling accelerates development of small cell lung cancer in mice
  2525. Protective Effect of Swertiamarin on Myocardial Injury Through Activation of Nrf2/HO-1 Pathway in Heart Failure Model of Rats.
  2526. Corrigendum to” Probucol improves erectile function via activation of Nrf2 and coordinates the HO-1/DDAH/PPAR-γ/eNOS pathways in streptozotocin-induced diabetic …
  2527. Fucoxanthin Attenuates Aβ-Induced Oxidative Stress via Akt/GSK-3β/Fyn-mediated Nrf2 Activation
  2528. Constitutive activation of Nrf2 antioxidant pathway leads to age-dependent goiter and compensated hypothyroidism in mice
  2529. Blue Mussel-derived Peptides Lead to Activation of Nrf2 and HO-1 Signaling Pathway to Alleviate H₂O₂-induced HUVEC Damage
  2530. Cytoprotective effects of fermented oyster extracts against oxidative stress-induced DNA damage and apoptosis through activation of the Nrf2/HO-1 signaling …
  2531. … of (-)-Linalool,(-)-Borneol and Trans-Caryophyllene Inhibits Inflammation and Apoptosis Through Suppression of NF-κB and Activation of Nrf2/HO-1 Signaling …
  2532. Protective effects of fermented oyster extracts against oxidative stress-induced-DNA damage and apoptosis through activation of the Nrf2/HO-1 signaling pathway in …
  2533. OR28-01 Constitutive Activation of NRF2 Antioxidant Response Leads to Age-Dependent Goiter and Compensated Hypothyroidism in Male Mice
  2534. … Via Suppression of Oxidative Stress-Associated Txnip and Peroxynitrite-Dominated Nlrp3 Inflammasome Activation by Motivating the Nrf2 Pathway after Subarachnoid …
  2535. CKIP-1 participates in the activation of Nrf2 signaling pathway by Cx43 and the regulation of diabetic renal fibrosis
  2536. … oxygen‑glucose deprivation/reperfusion injury by inhibiting oxidative stress and inflammatory response via the activation of SIRT1/Nrf2 signaling pathway in human …
  2537. Protective effects of naringin phospholipid complex on oxidative injury in ARPE-19 cells associated with activation of Nrf2 pathway
  2538. p62 promotes HIV-1 gp120 V3 loop-mediated microglial inflammation by promoting noncanonical activation of Nrf2
  2539. … AML-12 hepatocyte EMT and LX-2 HSC activation and alleviates mouse liver fibrosis provoked by CCl₄: roles in the activation of the Nrf2 cascade and subsequent …
  2540. Lycopene Induces Expression of NAD (P) H Quinone Oxidoreductase and Heme Oxygenase-1 through Activation of Nrf2 in Ethanol/LPS-stimulated Pancreatic Acinar …
  2541. … the secretion of IL‐8 in retinal pigment epithelial cells suffering from mitochondrial dysfunction via activation of nuclear factor erythroid 2 related factor 2 (NFE2L2/Nrf2)
  2542. Action dichotomique du cinnamaldehyde dans l’activation des kératinocytes: un rôle à jouer pour Nrf2?
  2543. Eudesmanolide from Salvia plebeia Protects H9c2 Cardiomyocytes Against Hypoxia/Reoxygenation-Induced Apoptosis with Nrf2 Activation
  2544. Isoliquiritigenin inhibits Oxidative Stress and Inflamamtion in LPS-Induced BEAS-2B Cells Involving Nrf2 Activation
  2545. 3-NP-induced Huntington’s-like disease impairs Nrf2 activation without loss of cardiac function in aged rats
  2546. Human papillomavirus 16 E7 promotes EGFR/PI3K/AKT1/NRF2 signaling pathway contributing to PIR/NF-κB activation in oral cancer cells
  2547. NRF2 Activation by Nitrogen Heterocycles: A Review
  2548. An updated patent review of Nrf2 activators (2020-present)
  2549. Activators of Nrf2 to Counteract Neurodegenerative Diseases
  2550. NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer
  2551. NRF2 Activation Reprograms Defects in Oxidative Metabolism to Restore Macrophage Function in Chronic Obstructive Pulmonary Disease
  2552. LncRNA MHRT Prevents Angiotensin II-Induced Myocardial Oxidative Stress and NLRP3 Inflammasome via Nrf2 Activation
  2553. Persistent activation of Nrf2 in a p62-dependent non-canonical manner aggravates lead-induced kidney injury by promoting apoptosis and inhibiting …
  2554. A comprehensive and mechanistic review on protective effects of kaempferol against natural and chemical toxins: Role of NF‐κB inhibition and Nrf2 activation
  2555. Olive oil promotes the survival and migration of dermal fibroblasts through Nrf2 pathway activation
  2556. N‐Acetylserotonin is an oxidation‐responsive activator of Nrf2 ameliorating colitis in rats
  2557. The Multi-Faceted Consequences of NRF2 Activation throughout Carcinogenesis
  2558. Optimization and evaluation of pyridinyl vinyl sulfones as Nrf2 activator for the antioxidant and anti-inflammatory effects
  2559. Activation of NRF2 blocks HIV replication and apoptosis in macrophages
  2560. Phenylsulfonimide PPARα Antagonists Enhance Nrf2 Activation and Promote Oxidative Stress-Induced Apoptosis/Pyroptosis in MCF7 Breast Cancer Cells
  2561. Omaveloxolone: an activator of Nrf2 for the treatment of Friedreich ataxia
  2562. Estradiol protects hair cells from cisplatin-induced ototoxicity via Nrf2 activation
  2563. Simultaneous Elimination of Reactive Oxygen Species and Activation of Nrf2 by Ultrasmall Nanoparticles to Relieve Acute Kidney Injury
  2564. Nrf2 Activation Does Not Protect from Aldosterone-Induced Kidney Damage in Mice
  2565. Synthesis of New Shogaol Analogues as NRF2 Activators and Evaluation of Their Anti-Inflammatory Activity, Modes of Action and Metabolic Stability
  2566. Nrf2 and its dependent autophagy activation cooperatively counteract ferroptosis to alleviate acute liver injury
  2567. Metformin suppresses oxidative stress induced by high glucose via activation of the Nrf2/HO-1 signaling pathway in type 2 diabetic osteoporosis
  2568. Identification of NRF2 Activation as a Prognostic Biomarker in T-Cell Acute Lymphoblastic Leukaemia
  2569. Phytochemical activators of Nrf2: a review of therapeutic strategies in diabetes: Phytochemical activators of Nrf2
  2570. CD4+ T Cell NRF2 Signaling Improves Liver Transplantation Outcomes by Modulating T Cell Activation and Differentiation
  2571. Developmental impacts of Nrf2 activation by dimethyl fumarate (DMF) in the developing zebrafish (Danio rerio) embryo
  2572. Quercetin and resveratrol inhibit ferroptosis independently of Nrf2–ARE activation in mouse hippocampal HT22 cells
  2573. Carnosic acid mitigates depression-like behavior in ovariectomized mice via activation of Nrf2/HO-1 pathway
  2574. Decrease in cholesterol in the cell membrane is essential for Nrf2 activation by quercetin
  2575. β-patchoulene alleviates cognitive dysfunction in a mouse model of sepsis associated encephalopathy by inhibition of microglia activation through Sirt1/Nrf2 …
  2576. Genistein and Procyanidin B2 Reduce Carcinogen-Induced Reactive Oxygen Species and DNA Damage through the Activation of Nrf2/ARE Cell Signaling in …
  2577. Lycopene ameliorates aflatoxin B1-induced testicular lesion by attenuating oxidative stress and mitochondrial damage with Nrf2 activation in mice
  2578. The Triterpenoid Nrf2 Activator, CDDO-Me, Decreases Neutrophil Senescence in a Murine Model of Joint Damage
  2579. SOCS1 Deficiency Promotes Hepatocellular Carcinoma via SOCS3-Dependent CDKN1A Induction and NRF2 Activation
  2580. Salidroside alleviates cognitive impairment by inhibiting ferroptosis via activation of the Nrf2/GPX4 axis in SAMP8 mice
  2581. Methyl eugenol protects the kidney from oxidative damage in mice by blocking the Nrf2 nuclear export signal through activation of the AMPK/GSK3β axis
  2582. … tanshinone IIA sulfonate protects against hyperhomocysteine-induced vascular endothelial injury via activation of NNMT/SIRT1-mediated NRF2/HO-1 and …
  2583. Nrf2-mediated activation of HO-1 is required in the blocking effect of compound K, a ginseng saponin metabolite, against oxidative stress damage in ARPE-19 …
  2584. … abrogates the protective effects of liraglutide on ischaemic stroke via inhibition of M2 polarisation and activation of NLRP3 inflammasome by reducing Nrf2 activation
  2585. S-allylmercapto-N-acetylcysteine ameliorates pulmonary fibrosis in mice via Nrf2 pathway activation and NF-κB, TGF-β1/Smad2/3 pathway suppression
  2586. Enhanced liquidity of p62 droplets mediated by Smurf1 links Nrf2 activation and autophagy
  2587. … from steam‐processed Polygonatum cyrtonema Hua protect against d‐galactose‐induced oxidative damage in mice by activation of Nrf2/HO‐1 signaling
  2588. Irisin attenuates ethanol-induced behavioral deficits in mice through activation of Nrf2 and inhibition of NF-κB pathways
  2589. Antioxidant and Anti-Inflammatory Mechanisms of Cardamonin through Nrf2 Activation and NF-kB Suppression in LPS-Activated BV-2 Microglial Cells
  2590. The Role of Fucoxanthin as a Potent Nrf2 Activator via Akt/GSK-3β/Fyn Axis against Amyloid-β Peptide-Induced Oxidative Damage
  2591. A homogeneous Lonicera japonica polysaccharide alleviates atopic dermatitis by promoting Nrf2 activation and NLRP3 inflammasome degradation via p62
  2592. Mangiferin protects DNase 2 abundance via Nrf2 activation to prevent cytosolic mtDNA accumulation during liver injury
  2593. Hesperetin ameliorates spinal cord injury by inhibiting NLRP3 inflammasome activation and pyroptosis through enhancing Nrf2 signaling
  2594. Choline and trimethylamine N-oxide impair metabolic activation of and platelet response to clopidogrel through activation of the NOX/ROS/Nrf2/CES1 pathway
  2595. The preventive effect of Mori Ramulus on oxidative stress-induced cellular damage in skeletal L6 myoblasts through Nrf2-mediated activation of HO-1
  2596. Pterostilbene attenuates hemin-induced dysregulation of macrophage M2 polarization via Nrf2 activation in experimental hyperglycemia
  2597. CRISPR/Cas9-Based Screening of FDA-Approved Drugs for NRF2 Activation: A Novel Approach to Discover Therapeutics for Non-Alcoholic Fatty Liver …
  2598. NRF2 activation suppresses motor neuron ferroptosis induced by the SOD1G93A mutation and exerts neuroprotection in amyotrophic lateral sclerosis
  2599. Melatonin attenuates bisphenol A-induced colon injury by dual targeting mitochondrial dynamics and Nrf2 antioxidant system via activation of SIRT1/PGC-1α signaling …
  2600. Suppression of MAPK/NF‐kB and activation of Nrf2 signaling by Ajugarin‐I in EAE model of multiple sclerosis
  2601. … protects against oleic acid-triggered mitochondrial dysfunction to relieve oxidative stress and inflammation via activation of the AMPK-Nrf2 axis by targeting GPR30 in …
  2602. 17β-estradiol plays the anti-osteoporosis role via a novel ESR1-Keap1-Nrf2 axis-mediated stress response activation and Tmem119 upregulation
  2603. … inhibits KGN cells oxidative stress and apoptosis and attenuates polycystic ovary syndrome phenotypes in mice through Keap1‐mediated Nrf2/HO‐1 activation
  2604. … ameliorates carbon tetrachloride-induced acute liver injury via the inhibition of oxidative stress, NF-κB pathways, and the activation of Nrf2/HO-1 pathway
  2605. … chronic restraint stress aggravated DSS-induced ulcerative colitis in mice via inhibition of NF-κB/STAT3 and activation of HO-1/Nrf2/SIRT1 signaling pathways
  2606. The anti-inflammatory and anti-oxidative effect of a classical hypnotic bromovalerylurea mediated by the activation of NRF2
  2607. Kaempferol ameliorates palmitate-induced lipid accumulation in HepG2 cells through activation of the Nrf2 signaling pathway
  2608. Sarmentosin induces autophagy-dependent apoptosis via activation of Nrf2 in hepatocellular carcinoma
  2609. Activation of NRF2 Signaling Pathway Delays the Progression of Hyperuricemic Nephropathy by Reducing Oxidative Stress
  2610. Involvement of the inhibition of mitochondrial apoptotic, p53, NF-κB pathways and the activation of Nrf2/HO-1 pathway in the protective effects of curcumin …
  2611. Dimethyl fumarate‐mediated Nrf2/ARE pathway activation and glibenclamide‐mediated NLRP3 inflammasome cascade inhibition alleviate type II diabetes …
  2612. Differential Activation of NRF2 Signaling Pathway in Renal-Cell Carcinoma Caki Cell Lines
  2613. Indian traditional rice variety “Gathuwan” suppresses T-cell-mediated immune responses via activation of ERK/Nrf2/HO-1 signalling pathway
  2614. PD184352 exerts anti-inflammatory and antioxidant effects by promoting activation of the Nrf2/HO-1 axis
  2615. SESN2-mediated AKT/GSK-3β/NRF2 Activation to Ameliorate Adriamycin Cardiotoxicity in High Fat Diet-induced Obese Mice
  2616. Cytoprotective Effect of Pteryxin on Insulinoma MIN6 Cells Due to Antioxidant Enzymes Expression via Nrf2/ARE Activation
  2617. Activation of Nrf2 signaling by 4-octyl itaconate attenuates the cartilaginous endplate degeneration by inhibiting E3 ubiquitin ligase ZNF598
  2618. Pharmacological activation of the Nrf2 pathway by Taxifolin remodels articular cartilage microenvironment for the therapy of Osteoarthritis
  2619. Copper induces liver lipotoxicity disease by up-regulating Nrf2 expression via the activation of MTF-1 and inhibition of SP1/Fyn pathway
  2620. … zinc alleviates tert-butyl hydroperoxide-induced mitochondrial oxidative stress on embryonic development involving the activation of Nrf2/PGC-1α pathway
  2621. Lycopene attenuates chlorpyrifos-induced hepatotoxicity in rats via activation of Nrf2/HO-1 axis
  2622. Nrf2 regulates the activation of THP-1 cells induced by chloral hydrate
  2623. Irisin drives macrophage anti-inflammatory differentiation via JAK2-STAT6-dependent activation of PPARγ and Nrf2 signaling
  2624. Sestrin2 provides cerebral protection through activation of Nrf2 signaling in microglia following subarachnoid hemorrhage
  2625. The inhibitory effect of vitamin D on myocardial homocysteine levels involves activation of Nrf2-mediated methionine synthase
  2626. Omentin-1 ameliorates experimental inflammatory bowel disease via Nrf2 activation and redox regulation
  2627. Photobiomodulation Controls Keratinocytes Inflammatory Response through Nrf2 and Reduces Langerhans Cells Activation
  2628. Osthole Antagonizes Microglial Activation in an NRF2-Dependent Manner
  2629. … effects of different doses of selenium against fluoride-triggered apoptosis and oxidative stress-mediated renal injury in rats through the activation of Nrf2/HO-1/NQO1 …
  2630. Bisphenol A-induced autophagy ameliorates human B cell death through Nrf2-mediated regulation of Atg7 and Beclin1 expression by Syk activation
  2631. Phytochemicals to regulate oxidative and electrophilic stress through Nrf2 activation
  2632. Knockdown of PHLDA1 alleviates necrotizing enterocolitis by inhibiting NLRP3 inflammasome activation and pyroptosis through enhancing Nrf2 signaling
  2633. Samarcandin protects against testicular ischemia/reperfusion injury in rats via activation of Nrf2/HO-1-mediated antioxidant responses
  2634. Activation of Nrf2 pathway as a protective mechanism against oxidative stress-induced diseases: Potential of astaxanthin
  2635. Selenomethionine attenuates ochratoxin A-induced small intestinal injury in rabbits by activating the Nrf2 pathway and inhibiting NF-κB activation
  2636. Astragaloside IV attenuates high glucose‐induced NF‐κB‐mediated inflammation through activation of PI3K/AKT‐ERK‐dependent Nrf2/ARE signaling pathway in …
  2637. AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells
  2638. Bioactive compounds in Layacha brown rice (Oryza sativa L.) improve immune responses in mice via activation of transcription factor Nrf2
  2639. H2S Alleviates Neuropathic Pain in Mice by Nrf2 Signaling Pathway Activation
  2640. … selenite preserves rBM-MSCs’ stemness, differentiation potential, and immunophenotype and protects them against oxidative stress via activation of the Nrf2 …
  2641. MitoQ alleviates triptolide-induced cardiotoxicity via activation of p62/Nrf2 axis in H9c2 cells
  2642. PPAR-γ Activation Alleviates Osteoarthritis through Both the Nrf2/NLRP3 and PGC-1α/Δψm Pathways by Inhibiting Pyroptosis
  2643. Kaempferol prevents acetaminophen-induced liver injury by suppressing hepatocyte ferroptosis via Nrf2 pathway activation
  2644. Salidroside alleviates acetaminophen-induced hepatotoxicity via Sirt1-mediated activation of Akt/Nrf2 pathway and suppression of NF-κB/NLRP3 inflammasome axis
  2645. Farnesol exerts protective effects against chronic sleep deprivation‐induced cognitive impairment via activation SIRT1/Nrf2 pathway in the hippocampi of adult mice
  2646. Suppression of neuronal apoptosis and glial activation with modulation of Nrf2/HO-1 and NF-kB signaling by curcumin in streptozotocin-induced diabetic …
  2647. A Preclinical Model for Parkinson’s Disease Based on Transcriptional Gene Activation via KEAP1/NRF2 to Develop New Antioxidant Therapies
  2648. Chemoprevention of lotus leaf ethanolic extract through epigenetic activation of the NRF2-mediated pathway in murine skin JB6 P+ cell neoplastic …
  2649. Hydroxy-Selenomethionine Mitigated Chronic Heat Stress-Induced Porcine Splenic Damage via Activation of Nrf2/Keap1 Signal and Suppression of NFκb …
  2650. … effects of bavachin against neuroinflammation and oxidative stress-induced neuronal damage via activation of Sirt1/Nrf2 pathway and inhibition of NF-κB …
  2651. BRG1 alleviates microglial activation by promoting the KEAP1-NRF2/HO-1 signaling pathway and minimizing oxidative damage in cerebral ischemia–reperfusion
  2652. Melatonin attenuates high glucose‑induced endothelial cell pyroptosis by activating the Nrf2 pathway to inhibit NLRP3 inflammasome activation
  2653. Saikosaponin A and D attenuate skeletal muscle atrophy in chronic kidney disease by reducing oxidative stress through activation of PI3K/AKT/Nrf2 pathway
  2654. Activation of α7nAChR by PNU282987 improves cognitive impairment through inhibiting oxidative stress and neuroinflammation in D-galactose induced …
  2655. Nrf2 Is Involved in Hyperglycemia-Induced Abnormal Lung Development Through Both Antioxidation-Dependent and Antioxidation-Independent Activation
  2656. Parthenolide Phytosomes Attenuated Gentamicin-Induced Nephrotoxicity in Rats via Activation of Sirt-1, Nrf2, OH-1, and NQO1 Axis
  2657. 6-Formylindolo (3, 2-b) carbazole Dampens Inflammation and Reduces Endotoxin-Induced Kidney Injury via Nrf2 Activation
  2658. Acylated ghrelin suppresses doxorubicin-induced testicular damage and improves sperm parameters in rats via activation of Nrf2 and mammalian target of rapamycin
  2659. Polyphyllin I induces apoptosis and autophagy in temozolomide-resistant glioma via modulation of NRF2 and MAPK-signaling activation
  2660. NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner
  2661. … cerebral neurotoxicity by activating Nrf2 and suppressing redox cycle imbalance, inflammatory iNOS/NO/NF-κB response and caspase-3/Bax activation in rats
  2662. Lipoxin A4 attenuated dexamethasone-induced muscle atrophy via activation of PGC-1α/Nrf2/TFAM pathway
  2663. Antioxidative effect of Periplaneta americana extract on dextran sulfate sodium-induced ulcerative colitis through activation of the Nrf2 signal
  2664. Dopamine D1 receptor activation ameliorates ox-LDL-induced endothelial cell senescence via CREB/Nrf2 pathway
  2665. Baicalein Alleviates Arsenic-induced Oxidative Stress through Activation of the Keap1/Nrf2 Signalling Pathway in Normal Human Liver Cells
  2666. … protein alleviates allodynia and improves Schwann cell function against diabetic peripheral neuropathy via activation of the Nrf2‐dependent antioxidant system and …
  2667. Zn and Se abrogate heavy metal mixture induced ovarian and thyroid oxido-inflammatory effects mediated by activation of NRF2-HMOX-1 in female albino …
  2668. δ-Opioid Receptor Activation Inhibits Ferroptosis by Activating the Nrf2 Pathway in MPTP-Induced Parkinson Disease Models
  2669. Structural basis of Nrf2 activation by flavonolignans from silymarin
  2670. Comments on “The ameliorative effect of kaempferol against CdCl2-mediated renal damage entails activation of Nrf2 and inhibition of NF-kB” by Alshehri Ali et al …
  2671. Activation of Nrf2/HO-1 antioxidant signaling correlates with the preventive effect of loganin on oxidative injury in ARPE-19 human retinal pigment epithelial cells
  2672. … Inhibits Oxidative Stress and NF-κB/NLRP3 Activation in Dextran Sulfate Sodium Salt-Induced Colitis in Mice with Involvement of the Nrf2 Signaling Pathway and …
  2673. Salidroside attenuates LPS-induced kidney injury through activation of SIRT1/Nrf2 pathway
  2674. Lung protective effects of dietary malate esters derivatives from Bletilla striata against SiO2 nanoparticles through activation of Nrf2 pathway
  2675. Activation of the Cap’n’collar C pathway (Nrf2 pathway in vertebrates) signaling in insulin pathway compromised Drosophila melanogaster flies ameliorates the …
  2676. Ferulic acid exerts a protective effect against cyclosporine‐induced liver injury in rats via activation of the Nrf2/HO‐1 signaling, suppression of oxidative stress …
  2677. Activation of PPARγ prevents ferroptosis-induced damage through Nrf2/Gpx4 signaling pathway in rat hippocampus following epilepsy
  2678. … metaplasia through NLR family pyrin domain-containing 3 (NLRP3)-mediated IL-33 activation via a reactive oxygen species (ROS)-NRF2-Heme oxygenase-1 (HO-1) …
  2679. Activation of the Keap1/Nrf2 Pathway as an Adaptive Response to an Electrophilic Metabolite of Morphine
  2680. NRF2 activation in the heart induces glucose metabolic reprogramming and mediates cardioprotection via upregulation of the pentose phosphate pathway.
  2681. Resolvin D1/N-formyl peptide receptor 2 ameliorates paclitaxel-induced neuropathic pain through the activation of IL-10/Nrf2/HO-1 pathway in mice
  2682. 6-Gingerol attenuates sepsis-induced acute lung injury by suppressing NLRP3 inflammasome through Nrf2 activation
  2683. Fucoidan Ameliorates Ferroptosis in Ischemia-reperfusion-induced Liver Injury through Nrf2/HO-1/GPX4 Activation
  2684. Succinylation of a KEAP1 sensor lysine promotes NRF2 activation
  2685. … Hepatocytes-Derived Extracellular Vesicles Ameliorated Liver Fibrosis in Mice via Suppression of TGF-β1/Smad Signaling and Activation of Nrf2/HO-1 Signaling
  2686. Targeted activation of Nrf2/HO‐1 pathway by Corynoline alleviates osteoporosis development
  2687. P235 Pharmacological activation of NRF2 has protective effects during Mycobacterium abscessus infection by promoting host defences and reducing inflammatory …
  2688. The Role of Nrf2 Activation and Autophagy in Aging and Neurodegenerative Diseases
  2689. Mountain-cultivated ginseng protects against cognitive impairments in aged GPx-1 knockout mice via activation of Nrf2/ChAT/ERK signaling pathway
  2690. Activation of the NLRP3 inflammasome by HMGB1 through inhibition of the Nrf2/HO-1 pathway promotes bleomycin-induced pulmonary fibrosis after acute lung injury …
  2691. Phenolic compound SG-1 from Balanophora harlandii and its derivatives exert anti-influenza A virus activity via activation of the Nrf2/HO-1 pathway
  2692. Baicalin Reduces Renal Inflammation in Mesangial Proliferative Glomerulonephritis through Activation of Nrf2/ARE and PI3K/AKT Pathways
  2693. Inhibition of p62-Keap1-Nrf2 Pathway Activation by Realgar Promotes the Inhibition of Esophageal Cancer Cell Proliferation, Migration, and Ferroptosis
  2694. CRISPR-Based Screening of FDA-Approved Drugs for NRF2 Activation: A Novel Approach to Discover Therapeutics for Non-Alcoholic Fatty Liver Disease
  2695. Two Weeks of Nrf2 Activation Improves Maximal Mitochondrial Respiration in Older Adults with Lower Starting Values
  2696. Cannabinoid type 2 receptor activation inhibits MPP+-induced M1 differentiation of microglia through activating PI3K/Akt/Nrf2 signal pathway
  2697. Flavonoids Activation of Nrf2 and Osteoporosis
  2698. Role of Flavonoid Activation of Nrf2 in Neurodegenerative Disease and Brain Aging
  2699. Balancing Nrf2 activation: A promising strategy for cancer treatment
  2700. Bryostatin‐1 attenuates intestinal ischemia/reperfusion‐induced intestinal barrier dysfunction, inflammation, and oxidative stress via activation of Nrf2/HO‐1 signaling
  2701. Reducing neurodegeneration and oxidative damage in Alzheimer’s disease: Role of the Nrf2 pathway activation by natural compounds
  2702. Pirfenidone attenuates nonalcoholic fatty liver disease through activation of the nuclear factor erythroid 2‐related factor 2 (Nrf2) signaling pathway
  2703. Protective effects of baicalin against L-glutamate-induced oxidative damage in HT-22 cells by inhibiting NLRP3 inflammasome activation via Nrf2/HO-1 signaling
  2704. Investigation into the Enhanced Activation of the ARE and the Correlations between NRF2 and Other Cytoprotective Pathways such as AHR, HSP, and Apoptosis
  2705. The Nrf2 activator tBHQ promotes OVA-Elicited Food Allergy in Mice
  2706. Lung-Targeted Delivery of Nrf2 Activators Promotes the Reversal of Age-Dependent Established Lung Fibrosis
  2707. Effect of Dunaliella salina on myocardial ischemia-reperfusion injury through KEAP1/NRF2 pathway activation and JAK2/STAT3 pathway inhibition
  2708. Sulforaphane alleviates psoriasis by enhancing antioxidant defense through KEAP1-NRF2 Pathway activation and attenuating inflammatory signaling
  2709. Retraction notice to “Cadmium induced cardiac oxidative stress in rats and its attenuation by GSP through the activation of Nrf2 signaling pathway”[Chem. Biol. Interact …
  2710. The reno-protective effect of celastrol mediated by Nrf2/HO-1 activation and NF-κB/NLRP3 suppression in hepatic ischemia/reperfusion model
  2711. Activation of Nrf2 Pathway by Natural Products
  2712. Activation of Nrf2 signaling pathway by Tectoridin protects against ferroptosis in particulate matter‐induced lung injury
  2713. Activation of NRF2-mediated oxidative stress response pathway by curcumin analog FLLL12: Implication for chemoprevention
  2714. Activation of Nrf2 by sulfuretin stimulates chondrocyte differentiation and increases bone lengths in zebrafish.
  2715. Hidrosmin Attenuates Inflammatory Response Induced by IL1β by Suppressing the Activation of NF-κB Involving Nrf2/HO1 Pathway in Human Osteoarthritis …
  2716. … myocardial infarction-induced cardiac fibrosis by targeting Keap1/Nrf2 to regulate oxidative stress and inhibit cardiac-fibroblast activation and proliferation”[Free Radic …
  2717. Low-dose Naltrexone (LDN) extends healthspan and lifespan through activation of the transcription factor SKN-1/NRF2 in C. elegans.
  2718. ACOD1 Facilitates p62-Mediated Keap1 Degradation for Nrf2 Activation to Reduce Neuroinflammation and Oxidative Stress Post Spinal Cord Contusion
  2719. A computational study to identify Sesamol derivatives as NRF2 activator for protection against drug-induced liver injury (DILI)
  2720. Diallyl disulfide blocks cigarette carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis via activation of Nrf2 antioxidant system and …
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