Extends Lifespan

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Overexpression of Atg5 in mice activates autophagy and extends lifespan
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans
Dietary deprivation extends lifespan in Caenorhabditis elegans
An antidepressant that extends lifespan in adult Caenorhabditis elegans
rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice
Increased fidelity of protein synthesis extends lifespan
Loss of pregnancy‐associated plasma protein A extends lifespan in mice
The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet
4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila
JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila
Extracellular vesicle-contained eNAMPT delays aging and extends lifespan in mice
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
D-beta-hydroxybutyrate extends lifespan in C. elegans
The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR
Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status
Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+
PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus
Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice
Restriction of amino acids extends lifespan in Drosophila melanogaster
Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/− mice
Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan
Preventing age-related decline of gut compartmentalization limits microbiota dysbiosis and extends lifespan
Dietary restriction extends lifespan through metabolic regulation of innate immunity
Glycine supplementation extends lifespan of male and female mice
Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice
Lonicera japonica extends lifespan and healthspan in Caenorhabditis elegans
Reduced circulating insulin enhances insulin sensitivity in old mice and extends lifespan
Roux‐en‐Y gastric bypass enhances energy expenditure and extends lifespan in diet‐induced obese rats
New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53−/− mice by delaying carcinogenesis
The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
The endogenous ligand Stunted of the GPCR Methuselah extends lifespan in Drosophila
Single-dose CRISPR–Cas9 therapy extends lifespan of mice with Hutchinson–Gilford progeria syndrome
Deletion of the Mitochondrial Superoxide Dismutase sod-2 extends lifespan in Caenorhabditis elegans
Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila
Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model
The mitochondria-targeted antioxidant MitoQ extends lifespan and improves healthspan of a transgenic Caenorhabditis elegans model of Alzheimer disease
The phytochemical, EGCG, extends lifespan by reducing liver and kidney function damage and improving age‐associated inflammation and oxidative stress in healthy …
Royalactin extends lifespan of Caenorhabditis elegans through epidermal growth factor signaling
Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome
Methionine restriction extends lifespan in progeroid mice and alters lipid and bile acid metabolism
Chemical activation of a food deprivation signal extends lifespan
Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice
Aspirin Inhibits Oxidant Stress, Reduces Age-Associated Functional Declines, and extends lifespan of Caenorhabditis elegans
Ssd1 and Gcn2 suppress global translation efficiency in replicatively aged yeast while their activation extends lifespan
Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria
Grape extract protects mitochondria from oxidative damage and improves locomotor dysfunction and extends lifespan in a Drosophila Parkinson’s disease model
Arginase-II deficiency extends lifespan in mice
Silymarin extends lifespan and reduces proteotoxicity in C. elegans Alzheimer’s model
Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice
Crosstalk between cellular compartments protects against proteotoxicity and extends lifespan
Mobilization‐based transplantation of young‐donor hematopoietic stem cells extends lifespan in mice
The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice
Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis
An isocaloric moderately high-fat diet extends lifespan in male rats and Drosophila
Overexpression of frataxin in the mitochondria increases resistance to oxidative stress and extends lifespan in Drosophila
Sodium rutin extends lifespan and health span in mice including positive impacts on liver health
Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a Drosophila model of Alzheimer’s disease
Lamotrigine extends lifespan but compromises health span in Drosophila melanogaster
Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice
Protocatechuic acid extends lifespan and increases stress resistance in Caenorhabditis elegans
Mitochondrial stress extends lifespan in C. elegans through neuronal hormesis
Chicoric Acid Is an Antioxidant Molecule That Stimulates AMP Kinase Pathway in L6 Myotubes and extends lifespan in Caenorhabditis elegans
Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans
PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila
Phosphatidylcholine extends lifespan via DAF-16 and reduces amyloid-beta-induced toxicity in Caenorhabditis elegans
Panax notoginseng polysaccharide increases stress resistance and extends lifespan in Caenorhabditis elegans
Dietary nitrite extends lifespan and prevents age-related locomotor decline in the fruit fly
L-Theanine extends lifespan of adult Caenorhabditis elegans
Rebaudioside A enhances resistance to oxidative stress and extends lifespan and healthspan in Caenorhabditis elegans
Drosophila insulin‐like peptide‐6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin‐like peptide‐2 from the brain
Stimulating S-adenosyl-l-methionine synthesis extends lifespan via activation of AMPK
Dietary Restriction extends lifespan in Wild-Derived Populations of Drosophila melanogaster
The phytochemical glaucarubinone promotes mitochondrial metabolism, reduces body fat, and extends lifespan of Caenorhabditis elegans
Systemic AAV9 gene transfer in adult GM1 gangliosidosis mice reduces lysosomal storage in CNS and extends lifespan
S100A9 extends lifespan in insulin deficiency
Sorbitol treatment extends lifespan and induces the osmotic stress response in Caenorhabditis elegans
The Drosophila homolog of methionine sulfoxide reductase A extends lifespan and increases nuclear localization of FOXO
Vitamin E extends lifespan in the short-lived rotifer Asplanchna brightwelli
Prohibitin depletion extends lifespan of a TORC2/SGK‐1 mutant through autophagy and the mitochondrial UPR
Withania somnifera root extract extends lifespan of Caenorhabditis elegans
Supplemental cellular protection by a carotenoid extends lifespan via Ins/IGF-1 signaling in Caenorhabditis elegans
Ginsenoside extract from ginseng extends lifespan and health span in Caenorhabditis elegans
Genetic reduction of mTOR extends lifespan in a mouse model of Hutchinson‐Gilford Progeria syndrome
Increased uncoupling protein (UCP) activity in Drosophila insulin-producing neurons attenuates insulin signaling and extends lifespan
Genetic inhibition of an ATP synthase subunit extends lifespan in C. elegans
Near-infrared light increases ATP, extends lifespan and improves mobility in aged Drosophila melanogaster
Guanabenz delays the onset of disease symptoms, extends lifespan, improves motor performance and attenuates motor neuron loss in the SOD1 G93A mouse model …
Purple sweet potato extract extends lifespan by activating autophagy pathway in male drosophila melanogaster
A novel antioxidant peptide purified from defatted round scad (Decapterus maruadsi) protein hydrolysate extends lifespan in Caenorhabditis elegans
Grape skin extract improves muscle function and extends lifespan of a Drosophila model of Parkinson’s disease through activation of mitophagy
A deuterohemin peptide extends lifespan and increases stress resistance in Caenorhabditis elegans
Pyrroloquinoline quinone enhances the resistance to oxidative stress and extends lifespan upon DAF-16 and SKN-1 activities in C. elegans
Rhodiola rosea extends lifespan and improves stress tolerance in silkworm, Bombyx mori
Maintenance of protein homeostasis in glia extends lifespan in C. elegans
N-Acetylcysteine extends lifespan of Drosophila via modulating ROS scavenger gene expression
… red wine consumption increases the expression of longevity-associated genes in controlled human populations and extends lifespan in Drosophila melanogaster
Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice
Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases
The absence of a mitochondrial genome in rho0 yeast cells extends lifespan independently of retrograde regulation
Verapamil extends lifespan in Caenorhabditis elegans by inhibiting calcineurin activity and promoting autophagy
A reduction in age-enhanced gluconeogenesis extends lifespan
Inhibition of autophagy delays motoneuron degeneration and extends lifespan in a mouse model of spinal muscular atrophy
Lonidamine extends lifespan of adult Caenorhabditis elegans by increasing the formation of mitochondrial reactive oxygen species
An antidiabetic polyherbal phytomedicine confers stress resistance and extends lifespan in Caenorhabditis elegans
Cyclin‐dependent kinase inhibition limits glomerulonephritis and extends lifespan of mice with systemic lupus
Carnitine promotes recovery from oxidative stress and extends lifespan in C. elegans
Emodin extends lifespan of Caenorhabditis elegans through insulin/IGF-1 signaling pathway depending on DAF-16 and SIR-2.1
PBT2 reduces toxicity in a C. elegans model of polyQ aggregation and extends lifespan, reduces striatal atrophy and improves motor performance in the R6/2 mouse …
The Yang-tonifying herbal medicine cynomorium songaricum extends lifespan and delays aging in drosophila
17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex
Resveratrol extends lifespan and preserves glia but not neurons of the Nothobranchius guentheri optic tectum
Metolazone upregulates mitochondrial chaperones and extends lifespan in Caenorhabditis elegans
Genistein from Vigna angularis extends lifespan in Caenorhabditis elegans
Sesamin extends lifespan through pathways related to dietary restriction in Caenorhabditis elegans
MicroRNA-455-3p improves synaptic, cognitive functions and extends lifespan: Relevance to Alzheimer’s disease
… of Streblus asper leaves protects against glutamate-induced toxicity in HT22 hippocampal neuronal cells and extends lifespan of Caenorhabditis elegans
Overexpression of pink1 or parkin in indirect flight muscles promotes mitochondrial proteostasis and extends lifespan in Drosophila melanogaster
Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice
Korean red ginseng tonic extends lifespan in D. melanogaster
Proteasome β5 subunit overexpression improves proteostasis during aging and extends lifespan in Drosophila melanogaster
TORC 1‐mediated sensing of chaperone activity alters glucose metabolism and extends lifespan
As predicted by hyperfunction theory, rapamycin treatment during development extends lifespan
Astragalus polysaccharide extends lifespan via mitigating endoplasmic reticulum stress in the silkworm, Bombyx mori
Echinacoside, a phenylethanoid glycoside from Cistanche deserticola, extends lifespan of Caenorhabditis elegans and protects from Aβ-induced toxicity
Cocoa improves age-associated health and extends lifespan in C. elegans
IgG3 deficiency extends lifespan and attenuates progression of glomerulonephritis in MRL/lprmice
Over-expression of human clusterin increases stress resistance and extends lifespan in Drosophila melanogaster
Early-stage treatment with Withaferin A reduces levels of misfolded superoxide dismutase 1 and extends lifespan in a mouse model of amyotrophic lateral …
S‐adenosyl‐L‐homocysteine extends lifespan through methionine restriction effects
A high-fat jelly diet restores bioenergetic balance and extends lifespan in the presence of motor dysfunction and lumbar spinal cord motor neuron loss in TDP …
A nutritional supplement containing lactoferrin stimulates the immune system, extends lifespan, and reduces amyloid β peptide toxicity in Caenorhabditis elegans
Minocycline treatment increases resistance to oxidative stress and extends lifespan in Drosophila via FOXO
Sonneradon A extends lifespan of Caenorhabditis elegans by Modulating Mitochondrial and IIS Signaling Pathways
Overexpression of metallothionein-I, a copper-regulating protein, attenuates intracellular copper dyshomeostasis and extends lifespan in a mouse model of …
Concentrated fish oil (Lovaza®) extends lifespan and attenuates kidney disease in lupus-prone short-lived (NZBxNZW) F1 mice
Caloric restriction extends lifespan of mothers at the expense of offspring survival in a predatory mite (Neoseiulus cucumeris)
Inhibition of histone acetyltransferase GCN5 extends lifespan in both yeast and human cell lines
Bark extract of the amazonian tree Endopleura uchi (Humiriaceae) extends lifespan and enhances stress resistance in Caenorhabditis elegans
Experimentally reduced insulin/IGF‐1 signaling in adulthood extends lifespan of parents and improves Darwinian fitness of their offspring
Rapamycin treatment during development extends lifespan and healthspan
Jouvence a small nucleolar RNA required in the gut extends lifespan in Drosophila
Activation of autophagy attenuates motor deficits and extends lifespan in a C. elegans model of ALS
Human IGF1 extends lifespan and enhances resistance to Plasmodium falciparum infection in the malaria vector Anopheles stephensi
Translational control of gene expression by eIF2 modulates proteostasis and extends lifespan
Dimethyl sulfide protects against oxidative stress and extends lifespan via a methionine sulfoxide reductase A‐dependent catalytic mechanism
Handelin extends lifespan and healthspan of Caenorhabditis elegans by reducing ROS generation and improving motor function
Expression of the dystrophin isoform Dp116 preserves functional muscle mass and extends lifespan without preventing dystrophy in severely dystrophic mice
Traditional tonifying polyherbal infusion, Jatu-Phala-Tiga, exerts antioxidant activities and extends lifespan of Caenorhabditis elegans
Neuron-specific overexpression of core clock genes improves stress-resistance and extends lifespan of Drosophila melanogaster
Ambient temperature reduction extends lifespan via activating cellular degradation activity in an annual fish (Nothobranchius rachovii)
Hypoxia extends lifespan of Brachionus manjavacas (Rotifera)
Intermittent exposure to fluorescent light extends lifespan of human diploid fibroblasts in culture
Neuronal‐specific proteasome augmentation via Prosβ5 overexpression extends lifespan and reduces age‐related cognitive decline
Ilex paraguariensis extends lifespan and Increases an Ability to Resist Environmental Stresses in Drosophila
FOXM1 delays senescence and extends lifespan
Glycerol extends lifespan of Brachionus manjavacas (Rotifera) and protects against stressors
Inhibition of a eukaryotic initiation factor (eIF2Bδ,/F11A3.2) during adulthood extends lifespan in Caenorhabditis elegans
Crotamiton derivative JM03 extends lifespan and improves oxidative and hypertonic stress resistance in Caenorhabditis elegans via inhibiting OSM-9
Brd2 haploinsufficiency extends lifespan and healthspan in C57B6/J mice
Reduced expression of alpha‐1,2‐mannosidase I extends lifespan in Drosophila melanogaster and Caenorhabditis elegans
Lentinan extends lifespan and increases oxidative stress resistance through DAF-16 and SKN-1 pathways in Caenorhabditis elegans
Hepatic lipase deficiency delays atherosclerosis, myocardial infarction, and cardiac dysfunction and extends lifespan in SR-BI/apolipoprotein E double knockout mice
Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse …
A double whammy for aging? Rapamycin extends lifespan and inhibits cancer in inbred female mice
Transition state analogue of MTAP extends lifespan of APCMin/+ mice
Astaxanthin extends lifespan via altered biogenesis of the mitochondrial respiratory chain complex III
Inhibition of GIP signaling extends lifespan without caloric restriction
IL-10 based immunomodulation initiated at birth extends lifespan in a familial mouse model of amyotrophic lateral sclerosis
Mutation of daf‐2 extends lifespan via tissue‐specific effectors that suppress distinct life‐limiting pathologies
Rejuvenation of the disposable soma: repeated injury extends lifespan in an asexual annelid
Reduced neuronal expression of ribose‐5‐phosphate isomerase enhances tolerance to oxidative stress, extends lifespan, and attenuates polyglutamine toxicity in …
Astragaloside IV extends lifespan of Caenorhabditis elegans by Improving Age-Related Functional Declines and Triggering Antioxidant Responses
The collagen-derived compound collagen tripeptide induces collagen expression and extends lifespan via a conserved p38 mitogen-activated protein kinase cascade
Chinese liquor extract attenuates oxidative damage in HepG2 cells and extends lifespan of Caenorhabditis elegans
DhHP-6 extends lifespan of Caenorhabditis elegans by enhancing nuclear translocation and transcriptional activity of DAF-16
A critical review of the evidence that metformin is a putative anti-aging drug that enhances healthspan and extends lifespan
Gemals, a new drug candidate, extends lifespan and improves electromyographic parameters in a rat model of amyotrophic lateral sclerosis
Identification of a sustainable two-plant diet that effectively prevents age-related metabolic syndrome and extends lifespan in aged mice
Liangyi Gao extends lifespan and exerts an antiaging effect in Caenorhabditis elegans by modulating DAF-16/FOXO
Reevaluation of whether a soma–to–germ-line transformation extends lifespan in Caenorhabditis elegans
Loss of NDG‐4 extends lifespan and stress resistance in Caenorhabditis elegans
Autophagy extends lifespan via vacuolar acidification
Reduced expression of frataxin extends the lifespan of Caenorhabditis elegans
Oleuropein Enhances Stress Resistance and extends lifespan via Insulin/IGF-1 and SKN-1/Nrf2 Signaling Pathway in Caenorhabditis elegans
Genetic perturbation of key central metabolic genes extends lifespan in Drosophila and affects response to dietary restriction
Jujube (Ziziphus Jujuba Mill.) fruit feeding extends lifespan and increases tolerance to environmental stresses by regulating aging-associated gene expression in …
A mid-life crisis for aging theory: from yeast to mice, limiting food intake slows aging and extends lifespan. Activators of the sirtuins, enzymes famously linked to this …
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans
PAK1-deficiency/down-regulation reduces brood size, activates HSP16. 2 gene and extends lifespan in Caenorhabditis elegans
Syntaxin 4 overexpression ameliorates effects of aging and high-fat diet on glucose control and extends lifespan
Streptococcus thermophilus extends lifespan through activation of DAF-16-mediated antioxidant pathway in Caenorhabditis elegans
The neuroprotector benzothiazepine CGP37157 extends lifespan in C. elegans worms
Enhancing mask activity in dopaminergic neurons extends lifespan in flies
Knockdown expression of eukaryotic initiation factor 5 C-terminal domain containing protein extends lifespan in Drosophila melanogaster
Cur2004-8, a synthetic curcumin derivative, extends lifespan and modulates age-related physiological changes in Caenorhabditis elegans
S-allylmercapto-N-acetylcysteine protects against oxidative stress and extends lifespan in Caenorhabditis elegans
Short-term enhancement of motor neuron synaptic exocytosis during early aging extends lifespan in Caenorhabditis elegans
Loss of miR-83 extends lifespan and affects target gene expression in an age-dependent manner in Caenorhabditis elegans
Alternative NADH dehydrogenase extends lifespan and increases resistance to xenobiotics in Drosophila
A C-terminal truncated mutation of spr-3 gene extends lifespan in Caenorhabditis elegans
Knock-down of odr-3 and ife-2 additively extends lifespan and healthspan in C. elegans
Ethanol extends lifespan of the rotifer Brachionus plicatilis
Increased Akt signaling in the fat body of Anopheles stephensi extends lifespan and increases lifetime fecundity through modulation of insulin-like peptides
Potassium restriction boosts vacuolar acidity and extends lifespan in yeast
A steroid hormone that extends the lifespan of Caenorhabditis elegans
Consumption of a low glycaemic index diet in late life extends lifespan of Balb/c mice with differential effects on DNA damage
2-SeCD treatment extends lifespan, improves healthspan and enhances resistance to stress in Caenorhabditis elegans
Rapamycin additively extends lifespan in short-and long-lived lines of the nematode Caenorhabditis remanei
Degradation of alpha-synuclein by dendritic cell factor 1 delays neurodegeneration and extends lifespan in Drosophila
Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan
Enhancing autophagy by redox regulation extends lifespan in Drosophila
Glucose extends lifespan through enhanced intestinal barrier integrity in Drosophila
Rapamycin extends maximal lifespan in cancer-prone mice
Dietary Glycine Supplementation extends lifespan of Genetically Heterogeneous Mice
Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan
10-Hydroxy-2-decenoic acid, the major lipid component of royal jelly, extends the lifespan of Caenorhabditis elegans through dietary restriction and target of …
Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK
Valproic acid extends Caenorhabditis elegans lifespan
Hyperactivation of the proteasome core particle in Caenorhabditis elegans protects against proteotoxic stress and extends lifespan
Osh6 overexpression extends the lifespan of yeast by increasing vacuole fusion
Pyropia haitanensis polysaccharide extends lifespan by inhibiting protein aggregation in Caenorhabditis elegans
Downregulation of EDTP in glial cells suppresses polyglutamine protein aggregates and extends lifespan in Drosophila melanogaster
Enhanced proteasome degradation extends Caenorhabditis elegans lifespan and alleviates aggregation-related pathologies
A genetic model of methionine restriction extends Drosophila health-and lifespan
Systemic delivery of rAAV6-microdystrophin preserves muscle function and extends lifespan in a murine model of severe muscular dystrophy
ENA-A actimineral resource A extends lifespan associated with antioxidant mechanism in SMP30 knockout mice
Overexpression of Fatty-Acid-𝜷-Oxidation-Related Genes extends the lifespan of Drosophila melanogaster
Transition state analogue of MTAP extends lifespan of APCMin/+ mice
Crocus sativus L. protects against SDS‑induced intestinal damage and extends lifespan in Drosophila melanogaster
PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila
Anti-aging effects of Ketanserin; Ketanserin extends lifespan in female drosophila, inhibits cellular senescence and promotes wound healing in-vitro
LanCL1 promotes motor neuron survival and extends the lifespan of amyotrophic lateral sclerosis mice
Lindera obtusiloba extends lifespan of Caenorhabditis elegans
Correction: PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila
Inhibition of retrotransposition improves health and extends lifespan of SIRT6 knockout mice
Fructose extends lifespan and Reduces Intestinal Fat Deposition in Caenorhabditis elegans
Ras inhibition by trametinib treatment in Drosophila attenuates gut pathology in females and extends lifespan in both sexes
Author Correction: IL-10 based immunomodulation initiated at birth extends lifespan in a familial mouse model of amyotrophic lateral sclerosis
Commentary: Sorbitol treatment extends lifespan and induces the osmotic stress response in Caenorhabditis elegans
Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans
eIF2B extends lifespan through inhibition of the integrated stress response
Valproic ACID extends lifespan of the Zebrafish Model of CLN2 Disease (Late Infantile Neuronal Ceroid Lipofuscinosis)
Dietary Restriction extends lifespan through Metabolic Regulation of Innate Immunity
Overexpression of protein carboxyl methyltransferase extends lifespan in Drosophila melanogaster
Antioxidant extends lifespan
d-Allulose, a stereoisomer of d-fructose, extends Caenorhabditis elegans lifespan through a dietary restriction mechanism: A new candidate dietary restriction mimetic
Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a Drosophila model of Alzheimer’s disease.
… of rheumatoid arthritis. Nat. Med. (2005) 11:936-943, and BARBER DF, BARTOLOMÉ A, HERNANDEZ C et al.: PI3Kg inhibition blocks glomerulonephritis and extends lifespan in a mouse …
INCREASE IN HSP25 extends lifespan AND IMPROVES RESPONSE TO TAU TOXICITY THROUGH A CELL, NON-AUTONOMOUS MECHANISM
Hepatocyte Transplantation (HTx) extends lifespan, Increases Branched Chain a-Keto Acid Dehydrogenase (BCKDH) Activity, and Improves Neurotransmitter and …
Systemic Administration of Telomerase RNA Reverses Vascular Senescence and extends lifespan in Progeria Mice
ZOLEDRONATE extends lifespan AND HEALTHSPAN IN VIVO
Ophiopogon japonicus herbal tea ameliorates oxidative stress and extends lifespan in caenorhabditis elegans
Lithium extends lifespan and Slows Brain Aging
NEURONAL-SPECIFIC PROTEASOME AUGMENTATION VIA extends lifespan AND REDUCES AGE-RELATED NEURODEGENERATION
Celecoxib extends C. elegans lifespan via inhibition of insulin‐like signaling but not cyclooxygenase‐2 activity
Downregulation of the tyrosine degradation pathway extends Drosophila lifespan
Inhibition of lipid peroxidation during the reproductive period extends the lifespan of Caenorhabditis elegans
REGULATION OF GLUCOSE STORAGE extends lifespan AND PROMOTES HEALTHSPAN
Prohibitin depletion extends lifespan of a TORC2/SGK-1 mutant through autophagy
No evidence that wine drinking extends lifespan
Drinking Chamomile Tea extends lifespan
Use of stable isotopes to examine how dietary restriction extends Drosophila lifespan
Royalactin extends lifespan of C. elegans through EGF signaling
Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins
A small molecule norathyriol extends lifespan in association with mitochondrial function in C. elegans
Supplementation with elenocysteine extends lifespan and modulates age-related physiological alterations in C. elegans
Chicoric Acid Promotes Glucose Uptake and extends lifespan
Enzyme role found for aging gene: two labs independently discover mechanism for how Sir2 extends lifespan.(Hot Papers)
Metformin extends C. elegans lifespan through lysosomal pathway
jouvence, a new small nucleolar RNA required in the gut extends lifespan in Drosophila
Long live the Queen-Royalactin extends lifespan of C. elegans through epidermal growth factor (EGF) signaling
β‐Guanidinopropionic acid extends the lifespan of Drosophila melanogaster via an AMP‐activated protein kinase‐dependent increase in autophagy
Korean Red Ginseng Tonic extends lifespan in D. melanogaster
Inhibition of Isw2‐mediated chromatin remodeling by calorie restriction extends lifespan by potentiating stress response
Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorh…
Alaskan Lowbush Cranberry extends lifespan in C. elegans
Tissue-specific downregulation of EDTP suppresses polyglutamine protein aggregates and extends lifespan in Drosophila
Fully hydrogenated canola oil extends lifespan in stroke-prone spontaneously hypertensive rats
Inhibition of autophagy delays motoneuron degeneration and extends lifespan in a mouse model of spinal muscular atrophy.
Rapamycin extends murine lifespan but has limited effects on aging
β‐Hydroxy‐β‐methylbutyrate extends lifespan and attenuates age‐dependent loss of flight ability in Drosophila melanogaster (246.2)
Corrigendum to “Autophagy induction extends lifespan and reduces lipids content in response to frataxin silencing in C. elegans”[Exp. Gerontol. 48 (2013) 191–201]
Geranylgeranylacetone Ameliorates Beta-Amyloid Toxicity and extends lifespan via the Heat Shock Response in Caenorhabditis elegans
Reprogrammed M1 macrophages with inhibited STAT3, STAT6 and/or SMAD3 extends lifespan of mice with experimental carcinoma
miR-17 extends mouse lifespan by inhibiting senescence signaling mediated by MKP7
… TREATMENT REGIMENS MITIGATE THE IMPACT OF RAPAMYCIN ON GLUCOSE HOMEOSTASIS AND THE IMMUNE SYSTEM, AND extends lifespan
Dietary restriction extends the lifespan of circadian mutants tim and per
Moderate hypoxia (10 kPa) extends lifespan with adult but not juvenile exposure in the fruitfly, Drosophila melanogaster
629. Intravenous Delivery of a MTMR2-Encoding AAV9 Vector extends lifespan and Improves Muscle Function in Mice with X-Linked Myotubular Myopathy
713. IntraCSF Administration of AAV9/MeCP2 extends lifespan of MeCP2-Null Mice While Preventing Toxicity Associated With IV Administration
Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan
Neoagarotetraose extends the lifespan of Caenorhabditis elegans through AMPK mediated signaling pathways and activation of autophagy
Is Gcn4-induced autophagy the ultimate downstream mechanism by which hormesis extends yeast replicative lifespan?
Nmdmc overexpression extends Drosophila lifespan and reduces levels of mitochondrial reactive oxygen species
Caffeine extends yeast lifespan by targeting TORC1
A salicylic acid derivative extends the lifespan of Caenorhabditis elegans by activating autophagy and the mitochondrial unfolded protein response
A new Schizosaccharomyces pombe chronological lifespan assay reveals that caloric restriction promotes efficient cell cycle exit and extends longevity
Ferulsinaic acid attenuation of advanced glycation end products extends the lifespan of Caenorhabditis elegans
Inhibition of GMP synthesis extends yeast replicative lifespan
CAN1 arginine permease deficiency extends yeast replicative lifespan via translational activation of stress response genes
HUMAN IGF1 extends MOZZIE lifespan
Restoration of energy homeostasis by SIRT6 extends healthy lifespan
Overexpression of malic enzyme in the larval stage extends Drosophila lifespan
Inhibitor GSK690693 extends Drosophila lifespan via reduce AKT signaling pathway
rBTI extends Caenorhabditis elegans lifespan by mimicking calorie restriction
Neuronal expression of a single‐subunit yeast NADH–ubiquinone oxidoreductase (Ndi1) extends Drosophila lifespan
Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan
Isonicotinamide extends yeast chronological lifespan through a mechanism that diminishes nucleotides
Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan
Aiweixin, a Traditional Uyghur Medicinal Formula, extends the lifespan of Caenorhabditis elegans
SIRT1 markedly extends replicative lifespan if the NAD+ salvage pathway is enhanced
Elevated Proteasome Capacity extends Replicative lifespan in Saccharomyces cerevisiae
Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity
Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway
Curcumin Acetylsalicylate extends the lifespan of Caenorhabditis elegans
gas1 mutation extends chronological lifespan via Pmk1 and Sty1 MAPKs in Schizosaccharomyces pombe
SKO1 deficiency extends chronological lifespan in Saccharomyces cerevisiae
Gengnianchun extends the lifespan of Caenorhabditis elegans via the insulin/IGF-1 signalling pathway
The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan
Deficiency of the RNA-binding protein Cth2 extends yeast replicative lifespan by alleviating its repressive effects on mitochondrial function
Reduced expression of C/EBPβ-LIP extends health and lifespan in mice
Post-reproductive inhibition of the autophagic vesicle nucleation complex extends C. elegans lifespan through the neurons
Growth hormone receptor gene disruption in mature-adult mice improves male insulin sensitivity and extends female lifespan
A novel gene, ecl1+, extends the chronological lifespan in fission yeast
Telomere elongation in the gut extends zebrafish lifespan
Low-dose chloroquine treatment extends the lifespan of aged rats
Glucosamine extends the lifespan of Caenorhabditis elegans via autophagy induction
Parishin from Gastrodia elata extends the lifespan of yeast via regulation of Sir2/Uth1/TOR signaling pathway
Acidic Food pH Increases Palatability and Consumption and extends Drosophila lifespan
Dairy Propionibacterium extends the mean lifespan of Caenorhabditis elegans via activation of the innate immune system
D-Allose, a Stereoisomer of D-Glucose, extends the lifespan of Caenorhabditis elegans via Sirtuin and Insulin Signaling D-Allose extends Nematode lifespan via …
Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway
Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice
Reduced expression of C/EBPb-LIP extends health and lifespan in mice
Korean mistletoe (Viscum album coloratum) extract extends the lifespan of nematodes and fruit flies
Mild Muscle Mitochondrial Fusion Distress extends Drosophila lifespan through an Early and Systemic Metabolome Reorganization
Iron supplementation delays aging and extends cellular lifespan through potentiation of mitochondrial function
Loss of tumor suppressor STAG2 promotes telomere recombination and extends the replicative lifespan of normal human cells
Tectochrysin increases stress resistance and extends the lifespan of Caenorhabditis elegans via FOXO/DAF-16
Sulfur restriction extends fission yeast chronological lifespan through Ecl1 family genes by downregulation of ribosome
Zymolytic Grain Extract (ZGE) Significantly extends the lifespan and Enhances the Environmental Stress Resistance of Caenorhabditis elegans
A mutation that alters the 255th glutamate to lysine in RSKS-1/S6 kinase reliably extends the lifespan of C. elegans
Expression of human HSP27 in yeast extends replicative lifespan and uncovers a hormetic response
Serum from calorie-restricted animals delays senescence and extends the lifespan of normal human fibroblasts in vitro
Gentiopicroside, a secoiridoid glycoside from Gentiana rigescens Franch, extends the lifespan of yeast via inducing mitophagy and antioxidative Stress
Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1 (+/−) mice
Nordihydroguaiaretic Acid extends the lifespan of Drosophila and Mice, Increases Mortality-Related Tumors and Hemorrhagic Diathesis, and Alters …
Honeysuckle extract (Lonicera pallasii L.) exerts antioxidant properties and extends the lifespan and healthspan of Drosophila melanogaster
Lithocholic Acid extends Yeast Chronological lifespan, Drives the Evolution of Longevity Regulation Mechanisms in Ecosystems and Suppresses Mitochondrial …
Inhibition of intestinal absorption of cholesterol by ezetimibe or bile acids by SC-435 alters lipoprotein metabolism and extends the lifespan of SR-BI/apoE double …
The retrotransposon Ty1 extends chronological lifespan in Saccharomyces paradoxus by influencing cellular responses to stress

Extends Lifespan

Star Protein

HMGB1

Senescence-Associated Beta-Galactosidase (Sa-β-gal Or Sabg)

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