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BCL-2

  1. 225Ac-Cd33 Radioimmunotherapy Potently Increases The Sensitivity Of Resistant Acute Myeloid Leukemia Lines To Theย Bcl-2ย Inhibitor Venetoclax By Mediating A โ€ฆ
  2. 613 Poster Gx15-070, A Small Moleculeย Bcl-2ย Family Inhibitor, Induces Apoptosis And Enhances Cisplatin-Induced Apoptosis In Non-Small Cell Lung Cancer โ€ฆ
  3. 8-Chrysoeriol, As A Potentialย Bcl-2ย Inhibitor Triggers Apoptosis Of Sw1990 Pancreatic Cancer Cells
  4. A Functionally Improved Locked Nucleic Acid Antisense Oligonucleotide Inhibitsย Bcl-2ย And Bcl-Xl Expression And Facilitates Tumor Cell Apoptosis
  5. A Literature Review Of The Patent Publications On Venetoclaxโ€“A Selectiveย Bcl-2ย Inhibitor: Discovering The Therapeutic Potential Of A Novel Chemotherapeutic Agent
  6. A Novelย Bcl-2ย Inhibitor, Bm-1197, Induces Apoptosis In Malignant Lymphoma Cells Through The Endogenous Apoptotic Pathway
  7. A Novelย Bcl-2ย Small Molecule Inhibitor 4-(3-Methoxy-Phenylsulfannyl)-7-Nitro-Benzofurazan-3-Oxide (Mnb)-Induced Apoptosis In Leukemia Cells
  8. A Novel Small Molecule Inhibitor Targeted Atย Bcl-2
  9. A Phase 1B/2 Clinical Study Of Targeted Idh1 Inhibition With Ivosidenib, In Combination With Theย Bcl-2ย Inhibitor Venetoclax, For Patients With Idh1-Mutated (Midh1) โ€ฆ
  10. A Phase I Study Of The Panย Bcl-2ย Family Inhibitor Obatoclax Mesylate In Patients With Advanced Hematologic Malignancies
  11. A Phase I Trial Of The Small Molecule Pan-Bcl-2ย Inhibitor Obatoclax (Gx15โ€“070) In Combination With Docetaxel In Patients With Relapsed Non-Small Cell Lung Cancer โ€ฆ
  12. A Phase Ib/Ii Study Of Theย Bcl-2ย Inhibitor Venetoclax In Combination With Standard Intensive Aml Induction/Consolidation Therapy With Flag-Ida In Patients With โ€ฆ
  13. A Safety And Schedule Seeking Trial Ofย Bcl-2ย Inhibitor Obatoclax In Previously Untreated Older Patients With Acute Myeloid Leukemia (Aml)
  14. A Small Molecule Inhibitor Ofย Bcl-2, Ha14-1, Also Inhibits Ceramide Glucosyltransferase
  15. A Small Molecule Pan-Bcl-2ย Family Inhibitor, Gx15-070, Induces Apoptosis And Enhances Cisplatin-Induced Apoptosis In Non-Small Cell Lung Cancer Cells
  16. A64 Cells Run A-Muc: Mucin Biology In The Lung: A Small Moleculeย Bcl-2ย Inhibitor Switches Il-13 To A Cell Death Inducer For Allergen-Induced Metaplastic โ€ฆ
  17. Aberrantly Expressed Fra-1 By Il-6/Stat3 Transactivation Promotes Colorectal Cancer Aggressiveness Through Epithelialโ€“Mesenchymal Transition
  18. Absorption, Metabolism, And Excretion Of A Novelย Bcl-2ย Inhibitor Venetoclax In Humans
  19. Abstract A245: Combination Of The Glycoengineered Type Ii Cd20 Antibody Obinutuzumab (Ga101), And The Novelย Bcl-2ย Selective Inhibitor, Abt-199 (Gdc-0199) โ€ฆ
  20. Abstract A30: Inhibition Of Pmca4 As A Strategy To Increase The Effectiveness Ofย Bcl-2ย Inhibitor-Mediated Cell Death In Breast Cancer Cells.
  21. Abstract A77: Repression Of Mtorc1 Activity In Notch1 Mutant T-All Results In Sensitivity To Theย Bcl-2ย Inhibitor Abt-263
  22. Abstract B4: A Microrna Screen To Identify Modulators Of Sensitivity Toย Bcl-2ย Inhibitor Abt-263
  23. Abstract Ct069: Correlative Biomarkers Of Clinical Activity Of Theย Bcl-2ย Inhibitor, Venetoclax (Abt-199/Gdc-0199), In Acute Myeloid Leukemia Patients
  24. Abstract Lb-212: Mcl-1 And Fbw7 Control A Dominant Survival Pathway Underlying Hdac Andย Bcl-2ย Inhibitor Synergy In Squamous Cell Carcinoma.
  25. Abstract Lb-72: An Immunoassay Detectingย Bcl-2: Bim And Mcl-1: Bim Complexes In The Phase 1 Monotherapy Study Of Theย Bcl-2ย Inhibitor, Abt-199/Gdc-0199, In โ€ฆ
  26. Abstract Pd1-06: A Phase 1B Dose-Escalation And Expansion Study Of Theย Bcl-2ย Inhibitor Venetoclax Combined With Tamoxifen In Er Andย Bcl-2โ€“Positive Metastatic โ€ฆ
  27. Abstract# 3990: The Pan-Bcl-2ย Family Inhibitor Abt-737 Synergizes With Dna Damaging Agents By Enhancing Apoptosis In Acute Lymphoblastic Leukemia Cells
  28. Abt-199, A Potent And Selectiveย Bcl-2ย Inhibitor, Achieves Antitumor Activity While Sparing Platelets
  29. Abt-737, An Inhibitor Ofย Bcl-2ย Family Proteins, Is A Potent Inducer Of Apoptosis In Multiple Myeloma Cells
  30. Abt-737: A Small Molecule Inhibitor Ofย Bcl-2ย With Dramatic Anti-Tumor Activity In Xenograft Models Of Small Cell Lung Cancer
  31. Abtโ€199 (Venetoclax), A Bh3โ€Mimetic Bclโ€2 Inhibitor, Does Not Cause Ca2+โ€Signalling Dysregulation Or Toxicity In Pancreatic Acinar Cells
  32. Abtโ€199 Selectively Inhibitsย Bcl-2ย But Notย Bcl-2ย L 1 And Efficiently Induces Apoptosis Of Chronic Lymphocytic Leukaemic Cells But Not Platelets
  33. Acquisition Of Resistance To Trastuzumab In Gastric Cancer Cells Is Associated With Activation Of Il-6/Stat3/Jagged-1/Notch Positive Feedback Loop
  34. Activation Of Stat3 In Human Gastric Cancer Cells Via Interleukin (Il)-6-Type Cytokine Signaling Correlates With Clinical Implications
  35. Activity Of Vincristine, L-Asparaginase, And Dexamethasone Against Acute Lymphoblastic Leukemia Was Enhanced By Theย Bcl-2ย Inhibitor Abt-737 In Vitro And In Vivo
  36. An Anti-Apoptoticย Bcl-2ย Family Protein Index Predicts The Response Of Leukemic Cells To The Pan-Bcl-2ย Inhibitor S1.
  37. An Efficient Synthesis Of Abt-263, A Novel Inhibitor Of Antiapoptoticย Bcl-2ย Proteins
  38. An Inhibitor Ofย Bcl-2ย Family Proteins Induces Regression Of Solid Tumours
  39. Anti-Allergic And Anti-Inflammatory Effects Of Theย Bcl-2ย Inhibitor Abt-737 On Experimental Allergic Rhinitis Models
  40. Antiangiogenic Effect Of Tw37, A Small-Molecule Inhibitor Ofย Bcl-2
  41. Anticancer Effect Of Icaritin Inhibits Cell Growth Of Colon Cancer Through Reactive Oxygen Species,ย Bclโ€‘2ย And Cyclin D1/E Signaling
  42. Antitumor Effects Of Sorafenib, Bevacizumab And Cetuximab As Single Agents Or In Combination With An Mek, Mtor Orย Bcl-2ย Inhibitor, In A Snu-398 Human โ€ฆ
  43. Apogossypolone, A Small-Molecule Inhibitor Ofย Bcl-2, Induces Radiosensitization Of Nasopharyngeal Carcinoma Cells By Stimulating Autophagy
  44. Apoptosis And Cell Cycle Arrest In Human Hepatocellular Carcinoma Cells And Enhance Chemosensitivity To Paclitaxel, Docetaxel, Doxorubicin And Theย Bcl-2ย Inhibitor โ€ฆ
  45. Apoptosis And Cell Cycle Arrest In Human Hepatocellular Carcinoma Cells And Enhance Chemosensitivity To Paclitaxel, Docetaxel, Doxorubicin And Theย Bclโ€“2ย Inhibitor โ€ฆ
  46. Apoptosis-Based Treatment Of Glioblastomas With Abt-737, A Novel Small Molecule Inhibitor Ofย Bcl-2ย Family Proteins
  47. Arsenic Trioxide Synergistically Enhances The Antileukemia Activity Ofย Bcl-2ย Inhibitor Abt-199 In Acute Myeloid Leukemia
  48. Aspirin Induces Apoptosis Through The Blockade Of Il-6-Stat3 Signaling Pathway In Human Glioblastoma A172 Cells
  49. Aspirin Promotes Apoptosis In A Murine Model Of Colorectal Cancer By Mechanisms Involving Downregulation Of Il-6โ€“Stat3 Signaling Pathway
  50. At-101, A Pan-Bcl-2ย Inhibitor, Leads To Radiosensitization Of Non-Small Cell Lung Cancer
  51. Autocrine Il-6-Induced Stat3 Activation Contributes To The Pathogenesis Of Lung Adenocarcinoma And Malignant Pleural Effusion
  52. Autophagy Eliminates Er Membrane Reorganization Induced Byย Bcl-2ย Inhibitor In Hela Cells
  53. Autophagy Inhibition Enhances Pan-Bcl-2ย Inhibitor At-101-Induced Apoptosis In Non-Small Cell Lung Cancer.
  54. Bcl-2ย Family Regulation By The 20S Proteasome Inhibitor Bortezomib
  55. Bcl-2ย Gene Silencing By Rna Interference Inhibits The Growth Of The Human Gallbladder Carcinoma Cell Line Gbc-Sd In Vitro And In Vivo
  56. Bcl-2ย Inhibitor Abt-737 Enhances The Cisplatin-Induced Apoptosis In Breast Cancer T47D Cells
  57. Bcl-2ย Inhibitor Ha14-1 And Genistein Together Adeptly Down Regulated Survival Factors And Activated Cysteine Proteases For Apoptosis In Human Malignant โ€ฆ
  58. Bcl-2ย Inhibitor Scaffolds That Are Preorganized Along An Axis Of Chirality; The Effect Of Atropisomerism On Protein Binding
  59. Bcl-2ย Inhibitor Uploaded Upconversion Nanophotosensitizers To Overcome The Photodynamic Therapy Resistance Of Cancer Through Adjuvant Intervention Strategy
  60. Bcl-2ย Inhibitor Venetoclax Enhances Temozolomide Sensitivity In Aml
  61. Bcl-2ย Selective Inhibitor Abt-199 Primes Rhabdomyosarcoma Cells To Histone Deacetylase Inhibitor-Induced Apoptosis
  62. Bclโ€2ย Inhibitors Enhance Fgfr Inhibitorโ€Induced Mitochondrialโ€Dependent Cell Death In Fgfr2โ€Mutant Endometrial Cancer
  63. Bevacizumab Synergizes With Theย Bcl-2ย Inhibitor Venetoclax To Effectively Treat Bโ€Cell Nonโ€Hodgkinโ€™S Lymphoma
  64. Bi-33, A Novel And Potent Pan-Bcl-2ย Inhibitor, Induces Apoptosis In Cancer Cells And Shows Combinational Effect With Chemo Drugs
  65. Binding Of Aย Bcl-2ย Family Inhibitor To Bovine Serum Albumin: Fluorescence Quenching And Molecular Docking Study
  66. Bortezomib Induces Oxidative Stress And Apoptosis That Are Synergistically Enhanced By Aย Bcl-2ย Inhibitor In Human Pancreatic Cancer Cells
  67. Breast Cancer Cells Can Evade Apoptosis-Mediated Selective Killing By A Novel Small Molecule Inhibitor Ofย Bcl-2
  68. Chemoresistance To Concanamycin A1 In Human Oral Squamous Cell Carcinoma Is Attenuated By An Hdac Inhibitor Partly Via Suppression Ofย Bcl-2ย Expression
  69. Clinical Experience With Theย Bcl-2โ€Inhibitor Venetoclax In Combination Therapy For Relapsed And Refractory Acute Myeloid Leukemia And Related Myeloid Malignancies
  70. Co-Administration Of The Mtorc1/Torc2 Inhibitor Ink128 And Theย Bcl-2/Bcl-Xl Antagonist Abt-737 Kills Human Myeloid Leukemia Cells Through Mcl-1 Down โ€ฆ
  71. Combinationย Bcl-2ย Inhibitor Therapy With Venetoclax And Navitoclax In Patients With Relapsed/Refractory Acute Lymphoblastic โ€ฆ
  72. Combination Of Guanine Arabinoside And Bclโ€2 Inhibitor Yc 137 Overcomes The Cytarabine Resistance In Hlโ€60 Leukemia Cell Line
  73. Combination Of The Glycoengineered Type Ii Cd20 Antibody Obinutuzumab (Ga101) And The Novelย Bcl-2ย Selective Inhibitor Gdc-0199 Results In Superior In Vitro And โ€ฆ
  74. Combining A Gsi Andย Bcl-2ย Inhibitor To Overcome Melanomaโ€™S Resistance To Current Treatments
  75. Critical Upstream Signals Of Cytochrome C Release Induced By A Novelย Bcl-2ย Inhibitor
  76. Cycling1 Amplification Enhances Aurora Kinase Inhibitor-Induced Polyploid Resistance And Inhibition Ofย Bcl-2ย Pathway Reverses The Resistance
  77. Deletion Of The Innate Immune Nlrp3 Receptor Abolishes Cardiac Ischemic Preconditioning And Is Associated With Decreased Il-6/Stat3 Signaling
  78. Development Of A Convergent Large-Scale Synthesis For Venetoclax, A First-In-Classย Bcl-2ย Selective Inhibitor
  79. Dipg-62. Carboplatin Synergizes Withย Bcl-2ย Inhibitor To Potentiate Killing Of Dipg Cells
  80. Discovery Of A Potent And Selectiveย Bcl-2ย Inhibitor Using Sar By Nmr
  81. Dna Damage Induces The Il-6/Stat3 Signaling Pathway, Which Has Anti-Senescence And Growth-Promoting Functions In Human Tumors
  82. Down-Regulation Of The Apoptosis-Inducing Factor Orย Bcl-2ย Inhibitor Of Transcription By Rna Interference Can Alleviate Tap63ฮ“-Induced Apoptosis In Esophageal โ€ฆ
  83. Dysregulated Mir-124 And Mir-200 Expression Contribute To Cholangiocyte Proliferation In The Cholestatic Liver By Targeting Il-6/Stat3 Signalling
  84. Early Data Promising For Pan-Bcl-2ย Inhibitor In Hematologic Malignancies
  85. Effect Of A Small Molecule Bclโ€2 Inhibitor On Immune Function And Use With A Recombinant Vaccine
  86. Effect Of Ketoconazole, A Strong Cyp3A Inhibitor, On The Pharmacokinetics Of Venetoclax, Aย Bclโ€2ย Inhibitor, In Patients With Nonโ€Hodgkin Lymphoma
  87. Effect Of Lowโ€And Highโ€Fat Meals On The Pharmacokinetics Of Venetoclax, A Selective Firstโ€Inโ€Classย Bclโ€2ย Inhibitor
  88. Effect Of Rifampin On The Pharmacokinetics, Safety And Tolerability Of Navitoclax (Abtโ€263), A Dual Inhibitor Ofย Bclโ€2ย And Bclโ€Xl, In Patients With Cancer
  89. Efficacy And Safety Ofย Bcl-2ย Inhibitor Venetoclax In Hematological Malignancy: A Systematic Review And Meta-Analysis Of Clinical Trials
  90. Efficacy Of The Pan-Bcl-2ย Inhibitor (Obatoclax) As A Single Agent To Treat Myeloproliferative Neoplasm In Jak2V617F Murine Transplantation Model
  91. Elevated Expression Of S100A8 And S100A9 Correlates With Resistance To Theย Bcl-2ย Inhibitor Venetoclax In Aml
  92. Embelin Reduces Colitis-Associated Tumorigenesis Through Limiting Il-6/Stat3 Signaling
  93. Epigenetic Alterations In Cholangiocarcinoma-Sustained Il-6/Stat3 Signaling In Cholangio-Carcinoma Due To Socs3 Epigenetic Silencing
  94. Evaluation Of Rifampinโ€™S Transporter Inhibitory And Cyp3A Inductive Effects On The Pharmacokinetics Of Venetoclax, Aย Bclโ€2ย Inhibitor: Results Of A Singleโ€And Multiple โ€ฆ
  95. Evaluation Of Theย Bcl-2ย Inhibitor Abt-199 In Xenograft Models Of Acute Lymphoblastic Leukemia By The Pediatric Preclinical Testing Program
  96. Exploring The Selectivity Of Inhibitor Complexes Withย Bcl-2ย And Bcl-Xl: A Molecular Dynamics Simulation Approach
  97. Exposure-Response Analyses Of The Effects Of Venetoclax, A Selectiveย Bcl-2ย Inhibitor, On B-Lymphocyte And Total Lymphocyte Counts In Women With Systemic โ€ฆ
  98. Extended Phase I Trial Of The Oral Pan-Bcl-2ย Inhibitor At-101 By Multiple Dosing Schedules In Patients With Advanced Cancers
  99. Fcn-338, A Novel And Selectiveย Bcl-2ย Inhibitor, Exhibits Potent Anti-Tumor Activity In B-Cell Lymphoma
  100. Fenretinide Via Noxa Induction, Enhanced Activity Of Theย Bcl-2ย Inhibitor Venetoclax In Highย Bcl-2โ€“Expressing Neuroblastoma Preclinical Models
  101. Genomic Analysis Of Small-Cell Lung Carcinomas: Discovery Of A Candidate Stratification Biomarker For Aย Bcl-2ย Inhibitor
  102. Gx15โ€“070 (Obatoclax), Aย Bcl-2ย Family Proteins Inhibitor Engenders Apoptosis And Pro-Survival Autophagy And Increases Chemosensitivity In Neuroblastoma
  103. Hematologic Tumor Cell Resistance To Theย Bcl-2ย Inhibitor Venetoclax: A Product Of Its Microenvironment?
  104. Hepatic Acute Phase Proteinsโ€“Regulation By Il-6-And Il-1-Type Cytokines Involving Stat3 And Its Crosstalk With Nf-ฮšb-Dependent Signaling
  105. Hmgb1-Il-23-Il-17-Il-6-Stat3 Axis Promotes Tumor Growth In Murine Models Of Melanoma
  106. Hsp90 Inhibitor (Nvp-Auy922) Enhances Anti-Cancer Effect Ofย Bcl-2ย Inhibitor (Abt-737) In Small Cell Lung Cancer
  107. Hsp90 Inhibitor (Nvp-Auy922) Enhances The Anti-Cancer Effect Ofย Bcl-2ย Inhibitor (Abt-737) In Small Cell Lung Cancer Expressingย Bcl-2
  108. Ibrutinib Combined With Car-T Cells In The Treatment Of Del (17P) Chronic Lymphocytic Leukemia Withย Bcl-2ย Inhibitor Resistance: A Case Report And Literature Review
  109. Identification Of A Novelย Bcl-2ย Inhibitor By Ligand-Based Screening And Investigation Of Its Anti-Cancer Effect On Human Breast Cancer Cells
  110. Il-17 Induces Akt-Dependent Il-6/Jak2/Stat3 Activation And Tumor Progression In Hepatocellular Carcinoma
  111. Il-6 Promotes Head And Neck Tumor Metastasis By Inducing Epithelialโ€“Mesenchymal Transition Via The Jak-Stat3-Snail Signaling Pathway
  112. Il-6 Trans-Signaling Modulates Tlr4-Dependent Inflammatory Responses Via Stat3
  113. Il-6 Trans-Signaling Via Stat3 Directs T Cell Infiltration In Acute Inflammation
  114. Il-6โ€“Gp130โ€“Stat3 In T Cells Directs The Development Of Il-17+ Th With A Minimum Effect On That Of Treg In The Steady State
  115. Il-6/Stat3/Tff3 Signaling Regulates Human Biliary Epithelial Cell Migration And Wound Healing In Vitro
  116. Immunosensitization With Aย Bcl-2ย Small Molecule Inhibitor
  117. Immunotoxin Andย Bcl-2ย Inhibitor Combination Therapy Targeting Chondroitin Sulfate Proteoglycan 4.
  118. Implantation Of Bone Marrow Mesenchymal Stem Cells Inhibitsย Bcl-2ย And Bax-Mediated Neuronal Apoptosis In Rats After Cerebral Ischemic Injury
  119. In Vitro Analysis Of Pan-Bcl-2ย Inhibitor Gx15-070 (Obatoclax) On Human Lymphocytes For The Feasibility Of Combination Immunotherapy.
  120. In Vivo And In Vitro Inhibition Of Osteosarcoma Growth By The Panย Bcl-2ย Inhibitor At-101
  121. In Vivo Efficacy Of At-101, An Orally Active Panย Bcl-2ย Family Protein Inhibitor In Combination With Docetaxel Or Erlotinib For Non Small Cell Lung Cancer Therapy
  122. In Vivo Efficacy Of Novel Methionine Aminopeptidase 2 Inhibitors, Alone And In Combination With Clinical Drugs And A Novelย Bcl-2ย Inhibitor
  123. Inducible Microrna-223 Down-Regulation Promotes Tlr-Triggered Il-6 And Il-1ฮ’ Production In Macrophages By Targeting Stat3
  124. Inducing Apoptosis In Mantle Cell Lymphoma Using Inhibitors Of Cyclin-Dependent Kinases And Theย Bcl-2ย Inhibitor Abt-737
  125. Induction Of Neutrophil Apoptosis By Aย Bcl-2ย Inhibitor Reduces Particulate Matter-Induced Lung Inflammation
  126. Induction Of Neutrophil Apoptosis Byย Bcl-2ย Inhibitor Reduces Pm-Induced Airway Inflammation
  127. Inhibiting Mitochondria Function Byย Bcl-2ย Inhibitor Venetoclax And Complex I Inhibitor Iacs-010759 Eliminate Leukemia Cells In Pre-Clinical Aml Models
  128. Inhibition Of Chk1 Enhances Cell Death Induced By Theย Bcl-2-Selective Inhibitor Abt-199 In Acute Myeloid Leukemia Cells
  129. Inhibition Of Growth Of Human Breast Cancer Cell Lines With The Combination Of An Egfr/Her-2/Neu Tyrosine Kinase Inhibitor And Aย Bcl-2ย Inhibitor
  130. Inhibition Of Growth Of Human Breast Cancer Cell Lines With The Combination Of An Mtor Inhibitor And Aย Bcl-2ย Inhibitor
  131. Inhibition Of Il-6/Stat3 Axis And Targeting Axl And Tyro3 Receptor Tyrosine Kinases By Apigenin Circumvent Taxol Resistance In Ovarian Cancer Cells
  132. Inhibition Of Stat3 Signaling Blocks The Anti-Apoptotic Activity Of Il-6 In Human Liver Cancer Cells
  133. Interaction Studies To Evaluate 2-Carboxyphenolate Analogues As Inhibitor Of Anti-Apoptotic Proteinย Bcl-2
  134. Interim Results From A Dose-Escalation Study Of Theย Bcl-2ย Inhibitor Venetoclax (Abt-199/Gdc-0199) Plus Bendamustine (B) And Rituximab (R) In Patients (Pts) With โ€ฆ
  135. Jak/Stat3 Pathway Inhibition Blocks Skeletal Muscle Wasting Downstream Of Il-6 And In Experimental Cancer Cachexia
  136. Lipopolysaccharides Upregulate Hepcidin In Neuron Via Microglia And The Il-6/Stat3 Signaling Pathway
  137. Lps And Tnfฮฑ Induce Socs3 Mrna And Inhibit Ilโ€6โ€Induced Activation Of Stat3 In Macrophages
  138. Mcl-1 And Bcl-Xl-Dependent Resistance To Theย Bcl-2ย Inhibitor Abt-199 Can Be Overcome By Preventing Pi3K/Akt/Mtor Activation In Lymphoid โ€ฆ
  139. Mcl-1 And Fbw7 Control A Dominant Survival Pathway Underlying Hdac Andย Bcl-2ย Inhibitor Synergy In Squamous Cell Carcinoma
  140. Mcl-1 Inhibitor-Induced Killing Of Multiple Myeloma Is Modulated By The Relative Level Of Expression Of Pro-Survival Members Of Theย Bcl-2ย Family And The Proto โ€ฆ
  141. Mcl-1 Or Bcl-Xl-Dependent Resistance To Theย Bcl-2ย Antagonist (Abt-199) Can Be Overcome By Specific Inhibitor As Single Agents And In Combination With Abt-199 In โ€ฆ
  142. Mcl-1 Up-Regulation Through Mapk Activation Confers Acquired Resistance Toย Bcl-2ย Inhibitor Abt-199 In Pre-Clinical Aml Models
  143. Metabolic Changes Associated With Metformin Potentiatesย Bcl-2ย Inhibitor, Venetoclax, And Cdk9 Inhibitor, Bay1143572 And Reduces Viability Of Lymphoma โ€ฆ
  144. Metformin Synergizes With Bcl-Xl/Bcl-2ย Inhibitor Abt-263 To Induce Apoptosis Specifically In P53-Defective Cancer Cells
  145. Metronomic Small Molecule Inhibitor Ofย Bcl-2ย (Tw-37) Is Antiangiogenic And Potentiates The Antitumor Effect Of Ionizing Radiation
  146. Mik665/S64315, A Novel Mcl-1 Inhibitor, In Combination Withย Bcl-2ย Inhibitors Exhibits Strong Synergistic Antitumor Activity In A Range Of Hematologic Malignancies
  147. Mir-143 Is Downregulated In Cervical Cancer And Promotes Apoptosis And Inhibits Tumor Formation By Targetingย Bcl-2
  148. Mir-17-92 Cluster Promotes Cholangiocarcinoma Growth: Evidence For Pten As Downstream Target And Il-6/Stat3 As Upstream Activator
  149. Mir-1915-3P Inhibitsย Bcl-2ย Expression In The Development Of Gastric Cancer
  150. Mirโ€1915 Inhibits Bclโ€2 To Modulate Multidrug Resistance By Increasing Drugโ€Sensitivity In Human Colorectal Carcinoma Cells
  151. Mitochondrial Targeting By Use Of Lipid Nanocapsules Loaded With Sv30, An Analogue Of The Small-Moleculeย Bcl-2ย Inhibitor Ha14-1
  152. Molecular Dynamic Simulations On An Inhibitor Of Anti-Apoptoticย Bcl-2ย Proteins For Insights Into Its Interaction Mechanism For Anti-Cancer Activity
  153. N-(3-Oxo-Acyl) Homoserine Lactone Inhibits Tumor Growth Independent Ofย Bcl-2ย Proteins
  154. Nโ€ฒ-((2-(6-Bromo-2-Oxo-2H-Chromen-3-Yl)-1H-Indol-3-Yl) Methylene) Benzohydrazide As A Probableย Bcl-2/Bcl-Xl Inhibitor With Apoptotic And Anti-Metastatic Potential
  155. Naringenin-Induced Apoptosis Is Attenuated Byย Bcl-2ย But Restored By The Small Moleculeย Bcl-2ย Inhibitor, Ha 14-1, In Human Leukemia U937 Cells
  156. Navitoclax, A Targeted High-Affinity Inhibitor Ofย Bcl-2, In Lymphoid Malignancies: A Phase 1 Dose-Escalation Study Of Safety, Pharmacokinetics, Pharmacodynamics, And โ€ฆ
  157. Non-Cell-Autonomous Activation Of Il-6/Stat3 Signaling Mediates Fgf19-Driven Hepatocarcinogenesis
  158. Obatoclax, A Pan-Bcl-2ย Inhibitor, Targets Cyclin D1 For Degradation To Induce Antiproliferation In Human Colorectal Carcinoma Cells
  159. Oocyte-Secreted Growth Differentiation Factor 9 Inhibitsย Bcl-2-Interacting Mediator Of Cell Death-Extra Long Expression In Porcine Cumulus Cell
  160. Overcoming Resistance To Ac0010, A Third Generation Of Egfr Inhibitor, By Targeting C-Met Andย Bcl-2
  161. Overcoming The Radioresistance Of Prostate Cancer Cells With A Novelย Bcl-2ย Inhibitor
  162. P53-Dependent Regulation Of Mcl-1 Contributes To Synergistic Cell Death By Ionizing Radiation And Theย Bcl-2/Bcl-Xl Inhibitor Abt-737
  163. Pan-Bcl-2ย Inhibitor At-101 Enhances Tumor Cell Killing By Egfr Targeted T Cells
  164. Pan-Bcl-2ย Inhibitor, Gx15-070 (Obatoclax), Decreases Human T Regulatory Lymphocytes While Preserving Effector T Lymphocytes: A Rationale For Its Use In Combination โ€ฆ
  165. Pediatric Preclinical Testing Program (Pptp) Evaluation Of Theย Bcl-2ย Inhibitor Abt-263
  166. Pharmacokinetics Of The B-Cell Lymphoma 2 (Bcl-2) Inhibitor Venetoclax In Female Subjects With Systemic Lupus Erythematosus
  167. Pharmacokinetics Of Theย Bcl-2ย Inhibitor Venetoclax In Subjects With Hepatic Impairment
  168. Pharmacokinetics Of Theย Bclโ€2ย Inhibitor Venetoclax In Healthy Chinese Subjects
  169. Pharmacokinetics Of Venetoclax, A Novelย Bclโ€2ย Inhibitor, In Patients With Relapsed Or Refractory Chronic Lymphocytic Leukemia Or Nonโ€Hodgkin Lymphoma
  170. Phase 1 Study Of The Safety, Pharmacokinetics, And Antitumour Activity Of Theย Bcl-2ย Inhibitor Navitoclax In Combination With Rituximab In Patients With Relapsed Or โ€ฆ
  171. Phase I Study Of A Novelย Bcl-2ย Inhibitor, At-101 In Combination With Lenalidomide And Dexamethasone In Patients With Relapsed And/Or Refractory Multiple Myeloma โ€ฆ
  172. Phase I Trial Of Escalating Doses Of Theย Bcl-2ย Inhibitor Venetoclax In Combination With Daunorubicin/Cytarabine Induction And High Dose Cytarabine Consolidation In โ€ฆ
  173. Pmca2 Silencing Potentiates Mda-Mb-231 Breast Cancer Cell Death Initiated With Theย Bcl-2ย Inhibitor Abt-263
  174. Potential Utility Of The Pan-Bcl-2ย Inhibitor Gx15โ€“070 (Obatoclax) In Cancer Immunotherapy
  175. Pre-Clinical Evaluation Ofย Bcl-2ย Inhibitor Abt-737 In Small Cell Lung Cancer
  176. Preclinical Evaluation Of Apoptosis Induction By The Novel Small Moleculeย Bcl-2ย Inhibitor, Gx015โ€“070, In Ex Vivo Chronic Lymphoid Leukemia (Cll) Cells
  177. Preclinical Study Of Aย Bcl-2ย Inhibitor In Neuroblastoma.
  178. Prediction Of Human Nonlinear Pharmacokinetics Of A Newย Bcl-2ย Inhibitor Using Pbpk Modeling And Interspecies Extrapolation Strategy
  179. Promise Of Combining Aย Bcl-2ย Family Inhibitor With Bortezomib Or Saha For Adult T-Cell Leukemia/Lymphoma
  180. Rac1 Mediates Stat3 Activation By Autocrine Il-6
  181. Radiosensitization By A Novelย Bcl-2ย And Bcl-Xl Inhibitor S44563 In Small-Cell Lung Cancer
  182. Rapid Complete Response To Single-Agentย Bcl-2ย Inhibitor Venetoclax In A Heart-Transplanted Patient With Triple Refractory Immunoglobulin Light-Chain Amyloidosis
  183. Ras Blockade Inhibitsย Bcl-2ย Modifying Factor (Bmf) Expression And Prevents Hypertension And Tubular Apoptosis In Diabetic Akita Mouse Kidneys
  184. Removed: Molecular Mechanisms Involved In Resistance Of Cll Cells Towards Abt-737, A Specificย Bcl-2ย Inhibitor
  185. Rnai Inhibitsย Bcl-2ย Gene Expression And Enhances Radio-Sensitivity Of Lung Adenocarcinoma Cell Line A549.
  186. S55746 Is A Novel Orally Activeย Bcl-2ย Selective And Potent Inhibitor That Impairs Hematological Tumor Growth
  187. Safety, Pharmacokinetics, Pharmacodynamics, And Activity Of Navitoclax, A Targeted High Affinity Inhibitor Ofย Bcl-2, In Lymphoid Malignancies
  188. Selectiveย Bcl-2ย Inhibitor Probes
  189. Ser727โ€Dependent Transcriptional Activation By Association Of P300 With Stat3 Upon Ilโ€6 Stimulation
  190. Small Moleculeย Bcl-2ย Inhibitor Enhances Apoptosis Induction By Gemcitabine Or Sulindac Sulfide In Bxpc-3 Pancreatic Cancer Cells
  191. Small Molecule Pan-Bcl-2ย Inhibitor At-101 Induces Apoptosis In Nsclc By Up-Regulating Noxa And Enhances Antitumor Activity Of Docetaxel Or Targeted Kinase โ€ฆ
  192. Small-Molecule Bh3 Mimetic And Pan-Bcl-2ย Inhibitor At-101 Enhances The Antitumor Efficacy Of Cisplatin Through Inhibition Of Ape1 Repair And Redox Activity In โ€ฆ
  193. Stat3 Activation By Il-6 From Mesenchymal Stem Cells Promotes The Proliferation And Metastasis Of Osteosarcoma
  194. Stat3 Activation In Response To Il-6 Is Prolonged By The Binding Of Il-6 Receptor To Egf Receptor
  195. Stat3 Mediates Ilโ€6โ€Induced Neuroendocrine Differentiation In Prostate Cancer Cells
  196. Statins Enhance Killing Of Multiple Myeloma Cells By Theย Bcl-2ย Inhibitor Venetoclax And The Mcl-1 Inhibitor S63845
  197. Sulindac Sulfideโ€“Induced Apoptosis Is Enhanced By A Small-Moleculeย Bcl-2ย Inhibitor And By Trail In Human Colon Cancer Cells Overexpressingย Bcl-2
  198. Survivin Inhibition Is Critical Forย Bcl-2ย Family Inhibitor, Abt-263 To Induce Apoptosis In Liver Cancer Cells
  199. Survivin Inhibition Is Critical Forย Bcl-2ย Inhibitor-Induced Apoptosis In Hepatocellular Carcinoma Cells
  200. Synergistic Aml Cell Death Induction By Marine Cytotoxin (+)-1 (R), 6 (S), 1โ€ฒ(R), 6โ€ฒ(S), 11 (R), 17 (S)-Fistularin-3 Andย Bcl-2ย Inhibitor Venetoclax
  201. Synergistic Combination Of Small Molecule Inhibitor And Rna Interference Against Antiapoptoticย Bcl-2ย Protein In Head And Neck Cancer Cells
  202. Synergistic Effect Ofย Bcl-2ย Inhibitor Apg-2575 And Cdk9 Inhibitor In Acute Myeloid Leukemia And Dlbcl Preclinical Tumor Models
  203. Synergistic Growth Inhibition Of Human Cancer Cells With Atrasentan And Aย Bcl-2ย Inhibitor
  204. Synergistic Induction Of Apoptosis By Theย Bcl-2ย Inhibitor Abt-737 And Imatinib Mesylate In Gastrointestinal Stromal Tumor Cells
  205. Synergistic Inhibition Of Breast Cancer Cell Lines With A Dual Inhibitor Of Egfr-Her-2/Neu And Aย Bcl-2ย Inhibitor
  206. Synergistic Inhibition Of Breast Cancer Cell Lines With The Combination Of A Dual Inhibitor Of Egfr/Her-2/Neu And Aย Bcl-2ย Inhibitor
  207. Synergistic Inhibition Of Tumor Growth By Combined Treatment With The Panย Bcl-2ย Inhibitor At-101 And Docetaxel In Human Cancer Xenograft Models
  208. Systemic Inhibition Of Il-6/Stat3 Signalling Protects Against Experimental Osteoarthritis
  209. Tanshinone Iia Inhibits Breast Cancer Stem Cells Growth In Vitro And In Vivo Through Attenuation Of Ilโ€6/Stat3/Nfโ€Kb Signaling Pathways
  210. Targeted Therapies For Epithelial Cancers: In Vivo Efficacy Of Theย Bcl-2/Bcl-Xl Inhibitor 2-Meaa
  211. Targeted Therapy With A Selectiveย Bcl-2ย Inhibitor In Older Patients With Acute Myeloid Leukemia
  212. Targeting 14-3-3 Sensitizes Native And Mutant Bcr-Abl To Inhibition With U0126, Rapamycin Andย Bcl-2ย Inhibitor Gx15-070
  213. Targeting Aml Through Apoptosis Activation Usingย Bcl-2/Mcl-1 Orย Bcl-2/Hdm2 Inhibitor Combination Therapies
  214. Targeting Apoptosis And Autophagy By A Novelย Bcl-2ย Inhibitor, Gx15-070, In Neuroblastoma.
  215. Targetingย Bcl-2ย Overexpression In Various Human Malignancies Through Nf-ฮšb Inhibition By The Proteasome Inhibitor Bortezomib
  216. Targeting The Il-6/Jak/Stat3 Signalling Axis In Cancer
  217. Telomerase Inhibitor Imetelstat In Combination With Theย Bcl-2ย Inhibitor Venetoclax Enhances Apoptosis In Vitro And Increases Survival In Vivo In Acute Myeloid โ€ฆ
  218. Theย Bcl-2ย Inhibitor Abt-199 Enhances Imatinib-Induced Cell Death In Chronic Phase Cml Progenitors
  219. Theย Bcl-2ย Inhibitor Abt-263 Enhances The Response Of Multiple Chemotherapeutic Regimens In Hematologic Tumors In Vivo
  220. Theย Bcl-2ย Inhibitor Abt-737 Shows Significant Anti-Tumor Efficacy In A Model Of Non-Hodgkinโ€™S B Cell Lymphoma
  221. Theย Bcl-2/Bcl-Xl Inhibitor Abt-737 Promotes Death Of Retinoblastoma Cancer Cells
  222. Theย Bcl-2/Bcl-Xl Inhibitor Bh3I-2โ€ฒ Affects The Dynamics And Subcellular Localization Of Sumoylated Proteins
  223. Theย Bclโ€2ย Inhibitor Venetoclax Inhibits Nrf2 Antioxidant Pathway Activation Induced By Hypomethylating Agents In Aml
  224. The Combination Of A Sphingosine Kinase 2 Inhibitor (Abc294640) And Aย Bclโ€2ย Inhibitor (Abtโ€199) Displays Synergistic Antiโ€Myeloma Effects In Myeloma Cells Without โ€ฆ
  225. The Cxcr4 Inhibitor Bl-8040 Induces The Apoptosis Of Aml Blasts By Downregulating Erk,ย Bcl-2, Mcl-1 And Cyclin-D1 Via Altered Mir-15A/16-1 Expression
  226. The Deubiquitinating Enzyme Inhibitor Pr-619 Enhances The Cytotoxicity Of Cisplatin Via The Suppression Of Anti-Apoptoticย Bcl-2ย Protein: In Vitro And In Vivo Study
  227. The Discovery Of Navitoclax, Aย Bcl-2ย Family Inhibitor
  228. The Dual Pi3K-ฮ”/ฮ“ Inhibitor Duvelisib In Combination With Theย Bcl-2ย Inhibitor Venetoclax Shows Promising Responses In Richter Syndrome-Pdx Models
  229. The Ewing Family Of Tumors Relies Onย Bcl-2ย And Bcl-Xl To Escape Parp Inhibitor Toxicity
  230. The Il-6โ€“Stat3 Axis Mediates A Reciprocal Crosstalk Between Cancer-Derived Mesenchymal Stem Cells And Neutrophils To Synergistically Prompt Gastric โ€ฆ
  231. The Il-6/Gp130/Stat3 Signaling Axis: Recent Advances Towards Specific Inhibition
  232. The Il-6/Jak/Stat3 Pathway: Potential Therapeutic Strategies In Treating Colorectal Cancer
  233. The Irreversible Erbb1/2/4 Inhibitor Neratinib Interacts With Theย Bcl-2ย Inhibitor Venetoclax To Kill Mammary Cancer Cells
  234. The Novel Antisenseย Bcl-2ย Inhibitor Spc2996 Causes Rapid Leukemic Cell Clearance And Immune Activation In Chronic Lymphocytic Leukemia
  235. The Novel Imipridone Onc212 Highly Synergizes With Theย Bcl-2ย Inhibitor Abt-199 In Aml And Activates Orphan Receptor Gpr132
  236. The Pan-Bcl-2ย Inhibitor (โˆ’)-Gossypol Triggers Autophagic Cell Death In Malignant Glioma
  237. The Proteasome Inhibitor Bortezomib Promotes Mitochondrial Injury And Apoptosis Induced By The Small Moleculeย Bcl-2ย Inhibitor Ha14-1 In Multiple Myeloma Cells
  238. The Selectiveย Bcl-2ย Inhibitor Abt-199 Induces Cell Death Via The Intrinsic Apoptotic Pathway In Canine B-Cell And T-Cell Lymphoma Cell Lines
  239. The Sensitivity Of Diffuse Large B-Cell Lymphoma Cell Lines To Histone Deacetylase Inhibitor-Induced Apoptosis Is Modulated Byย Bcl-2ย Family Protein Activity
  240. The Small Moleculeย Bcl-2ย Inhibitor Ha14-1 Interacts Synergistically With Flavopiridol To Induce Mitochondrial Injury And Apoptosis In Human Myeloma Cells Through A โ€ฆ
  241. The Small Moleculeย Bcl-2ย Inhibitor Ha14-1 Potentiates The Lethality Of A Regimen Combining Mek1/2 And Chk1 Inhibitors In Multiple Myeloma Cells
  242. The Small Moleculeย Bcl-2/Mcl-1 Inhibitor Tw-37 Shows Single-Agent Cytotoxicity In Neuroblastoma Cell Lines
  243. The Small Molecule Pan-Bcl-2ย Inhibitor Gx15-070 Induces Apoptosis In Vitro In Mantle Cell Lymphoma (Mcl) Cells And Exhibits A Synergistic Effect In Combination With โ€ฆ
  244. The Small-Moleculeย Bcl-2ย Inhibitor Ha14-1 Interacts Synergistically With Flavopiridol To Induce Mitochondrial Injury And Apoptosis In Human Myeloma Cells Through A โ€ฆ
  245. The Use Of Theย Bcl-2ย Inhibitor In Cll Patients Who Progressed After B-Cell-Receptor Inhibitors: A Retrospective Multicenter โ€ฆ
  246. Therapeutic Efficacy Of Abt-737, Aย Bcl-2ย Inhibitor, In A Canine Melanoma Cell Line
  247. Therapeutic Silencing Ofย Bcl-2ย By Systemically Administered Sirna Nanotherapeutics Inhibits Tumor Growth By Autophagy And Apoptosis And Enhances The โ€ฆ
  248. Therapeutic Targeting Of Il-6 Trans Signaling Counteracts Stat3 Control Of Experimental Inflammatory Arthritis
  249. Thu0282 Exposure-Response Analyses Of Effects Of Venetoclax, A Selectiveย Bcl-2ย Inhibitor, On B And Total Lymphocyte Counts In Female Subjects With Systemic โ€ฆ
  250. Thu0306 Safety, Tolerability, Pharmacokinetics, And Pharmacodynamics Of Theย Bcl-2ย Inhibitor Venetoclax (Abt-199) In A Phase 1 Single And Multiple Ascending โ€ฆ
  251. Thu0382 Venetoclax (Abt-199), A Potent And Selectiveย Bcl-2ย Inhibitor, Prevents Nephritis In Lupus Prone Nzb/W F1 Mice By Depleting Selective Lymphocyte โ€ฆ
  252. To Overcoming Rituximab-Chemotherapy Resistance By Targeting The Autophagy Pathway Using Bortezomib In Combination With Theย Bcl-2ย Inhibitor Obatoclax In Non โ€ฆ
  253. Transcriptional Inactivation Of Stat3 By Pparฮณ Suppresses Il-6-Responsive Multiple Myeloma Cells
  254. Tumor Growth Inhibition Modelling Based On Receptor Occupancy And Biomarker Activity Of A Newย Bcl-2ย Inhibitor In Mice
  255. Tumor Necrosis Factorโ€“Related Apoptosis-Inducing Ligandโ€“Induced Apoptosis Is Inhibited Byย Bcl-2ย But Restored By The Small Moleculeย Bcl-2ย Inhibitor, Ha 14-1, In โ€ฆ
  256. Tw-37, A Nonpeptidic Small-Molecule Inhibitor Ofย Bcl-2, Inhibits Cell Invasion And Angiogenesis In Pancreatic Cancer
  257. Updated Results Of A Phase I First-In-Human Study Of Theย Bcl-2ย Inhibitor Abt-199 (Gdc-0199) In Patients With Relapsed/Refractory Non-Hodgkin Lymphoma (Nhl).
  258. Venclexta (Venetoclax) Firstย Bcl-2ย Inhibitor Approved For High-Risk Relapsed Chronic Lymphocytic Leukemia
  259. Venetoclax (Abt-199), A Potent And Selectiveย Bcl-2ย Inhibitor, Is Efficacious In Nzb/Wf1 Mouse Model Of Lupus Nephritis And Reduces Human Lymphocyte Lifespan In โ€ฆ
  260. Venetoclax, A Novelย Bcl-2ย Inhibitor, Induces Cell Growth Suppression, Apoptosis, Cell Cycle Arrest, And Autophagy In Triple Negative Breast Cancer Mda-Mb-231 โ€ฆ
  261. Vesicular Stomatitis Virus Andย Bcl-2ย Inhibitor Combination Therapy For The Treatment Of Chronic Lymphocytic Leukemia
  262. Virtual Screening, Sar, And Discovery Of 5โ€(Indoleโ€3โ€Yl)โ€2โ€[(2โ€Nitrophenyl) Amino][1, 3, 4]โ€Oxadiazole As A Novelย Bclโ€2ย Inhibitor
  263. Vsv Oncolysis In Combination With Theย Bcl-2ย Inhibitor Obatoclax Overcomes Apoptosis Resistance In Chronic Lymphocytic Leukemia
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